Academic literature on the topic 'Substitution rate evolution'

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Journal articles on the topic "Substitution rate evolution"

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Woolfit, Megan. "Effective population size and the rate and pattern of nucleotide substitutions." Biology Letters 5, no. 3 (2009): 417–20. http://dx.doi.org/10.1098/rsbl.2009.0155.

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Both the overall rate of nucleotide substitution and the relative proportions of synonymous and non-synonymous substitutions are predicted to vary between species that differ in effective population size ( N e ). Our understanding of the genetic processes underlying these lineage-specific differences in molecular evolution is still developing. Empirical analyses indicate that variation in substitution rates and patterns caused by differences in N e is often substantial, however, and must be accounted for in analyses of molecular evolution.
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Streck, André Felipe, Sandro Luis Bonatto, Timo Homeier, et al. "High rate of viral evolution in the capsid protein of porcine parvovirus." Journal of General Virology 92, no. 11 (2011): 2628–36. http://dx.doi.org/10.1099/vir.0.033662-0.

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In recent years, it has been shown that some parvoviruses exhibit high substitution rates, close to those of RNA viruses. In order to monitor and determine new mutations in porcine parvovirus (PPV), recent PPV field isolates from Austria, Brazil, Germany and Switzerland were sequenced and analysed. These samples, together with sequences retrieved from GenBank, were included in three datasets, consisting of the complete NS1 and VP1 genes and a partial VP1 gene. For each dataset, the nucleotide substitution rate and the molecular clock were determined. Analysis of the PPV field isolates revealed
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Tillier, Elisabeth R. M., and Richard A. Collins. "High Apparent Rate of Simultaneous Compensatory Base-Pair Substitutions in Ribosomal RNA." Genetics 148, no. 4 (1998): 1993–2002. http://dx.doi.org/10.1093/genetics/148.4.1993.

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Abstract We present a model for the evolution of paired bases in RNA sequences. The new model allows for the instantaneous rate of substitution of both members of a base pair in a compensatory substitution (e.g., A-U→G-C) and expands our previous work by allowing for unpaired bases or noncanonical pairs. We implemented the model with distance and maximum likelihood methods to estimate the rates of simultaneous substitution of both bases, αd, vs. rates of substitution of individual bases, αs in rRNA. In the rapidly evolving D2 expansion segments of Drosophila large subunit rRNA, we estimate a l
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Takano, Toshiyuki S. "Rate Variation of DNA Sequence Evolution in the Drosophila Lineages." Genetics 149, no. 2 (1998): 959–70. http://dx.doi.org/10.1093/genetics/149.2.959.

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Abstract Rate constancy of DNA sequence evolution was examined for three species of Drosophila, using two samples: the published sequences of eight genes from regions of the normal recombination rates and new data of the four AS-C (ac, sc, l'sc and ase) and ci genes. The AS-C and ci genes were chosen because these genes are located in the regions of very reduced recombination in Drosophila melanogaster and their locations remain unchanged throughout the entire lineages involved, yielding less effect of ancestral polymorphism in the study of rate constancy. The synonymous substitution pattern o
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Stephan, Wolfgang. "The Rate of Compensatory Evolution." Genetics 144, no. 1 (1996): 419–26. http://dx.doi.org/10.1093/genetics/144.1.419.

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Abstract A two-locus model is presented to analyze the evolution of compensatory mutations occurring in stems of RNA secondary structures. Single mutations are assumed to be deleterious but harmless (neutral) in appropriate combinations. In proceeding under mutation pressure, natural selection and genetic drift from one fitness peak to another one, a population must therefore pass through a valley of intermediate deleterious states of individual fitness. The expected time for this transition is calculated using diffusion theory. The rate of compensatory evolution, kc, is then defined as the in
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Bielawski, Joseph P., Katherine A. Dunn, and Ziheng Yang. "Rates of Nucleotide Substitution and Mammalian Nuclear Gene Evolution: Approximate and Maximum-Likelihood Methods Lead to Different Conclusions." Genetics 156, no. 3 (2000): 1299–308. http://dx.doi.org/10.1093/genetics/156.3.1299.

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Abstract Rates and patterns of synonymous and nonsynonymous substitutions have important implications for the origin and maintenance of mammalian isochores and the effectiveness of selection at synonymous sites. Previous studies of mammalian nuclear genes largely employed approximate methods to estimate rates of nonsynonymous and synonymous substitutions. Because these methods did not account for major features of DNA sequence evolution such as transition/transversion rate bias and unequal codon usage, they might not have produced reliable results. To evaluate the impact of the estimation meth
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Zhang, Jianzhi, and Xun Gu. "Correlation Between the Substitution Rate and Rate Variation Among Sites in Protein Evolution." Genetics 149, no. 3 (1998): 1615–25. http://dx.doi.org/10.1093/genetics/149.3.1615.

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Abstract It is well known that the rate of amino acid substitution varies among different proteins and among different sites of a protein. It is, however, unclear whether the extent of rate variation among sites of a protein and the mean substitution rate of the protein are correlated. We used two approaches to analyze orthologous protein sequences of 51 nuclear genes of vertebrates and 13 mitochondrial genes of mammals. In the first approach, no assumptions of the distribution of the rate variation among sites were made, and in the second approach, the gamma distribution was assumed. Through
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Duffy, Siobain, and Edward C. Holmes. "Phylogenetic Evidence for Rapid Rates of Molecular Evolution in the Single-Stranded DNA Begomovirus Tomato Yellow Leaf Curl Virus." Journal of Virology 82, no. 2 (2007): 957–65. http://dx.doi.org/10.1128/jvi.01929-07.

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ABSTRACT Geminiviruses are devastating viruses of plants that possess single-stranded DNA (ssDNA) DNA genomes. Despite the importance of this class of phytopathogen, there have been no estimates of the rate of nucleotide substitution in the geminiviruses. We report here the evolutionary rate of the tomato yellow leaf curl disease-causing viruses, an intensively studied group of monopartite begomoviruses. Sequences from GenBank, isolated from diseased plants between 1988 and 2006, were analyzed using Bayesian coalescent methods. The mean genomic substitution rate was estimated to be 2.88 × 10−4
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Grigoras, Ioana, Tatiana Timchenko, Ana Grande-Pérez, Lina Katul, Heinrich-Josef Vetten, and Bruno Gronenborn. "High Variability and Rapid Evolution of a Nanovirus." Journal of Virology 84, no. 18 (2010): 9105–17. http://dx.doi.org/10.1128/jvi.00607-10.

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ABSTRACT Nanoviruses are multipartite single-stranded DNA (ssDNA) plant viruses that cause important diseases of leguminous crops and banana. Little has been known about the variability and molecular evolution of these viruses. Here we report on the variability of faba bean necrotic stunt virus (FBNSV), a nanovirus from Ethiopia. We found mutation frequencies of 7.52 × 10−4 substitutions per nucleotide in a field population of the virus and 5.07 × 10−4 substitutions per nucleotide in a laboratory-maintained population derived thereof. Based on virus propagation for a period of more than 2 year
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Mugal, C. F., J. B. W. Wolf, H. H. von Grünberg, and H. Ellegren. "Conservation of Neutral Substitution Rate and Substitutional Asymmetries in Mammalian Genes." Genome Biology and Evolution 2 (January 1, 2010): 19–28. http://dx.doi.org/10.1093/gbe/evp056.

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Dissertations / Theses on the topic "Substitution rate evolution"

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Botha, Stephen Gordon. "The effect of evolutionary rate estimation methods on correlations observed between substitution rates in models of evolution." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/19938.

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Mugal, Carina Farah. "Nucleotide Substitution Patterns in Vertebrate Genomes." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198787.

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The rates and patterns at which nucleotide substitutions occur vary significantly across the genome sequence of vertebrates. A prominent example is the difference in the rate of evolution of functional sequences versus nonfunctional (neutrally evolving) sequences, which is explained by the influence of natural selection on functional sequences. However, even within neutrally evolving sequences there is striking variation in the rates and patterns of nucleotide substitutions. Unraveling the underlying processes that induce this variation is necessary to understand the basic principles of variat
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Raj, Kumar Praveen Kumar. "APPLICATION OF TRANSCRIPTOMICS TO ADDRESS QUESTIONS IN MOLECULAR BIOLOGY AND EVOLUTION." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1410427259.

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Hermansen, Russell A., Brian K. Mannakee, Wolfgang Knecht, David A. Liberles, and Ryan N. Gutenkunst. "Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610280.

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BACKGROUND: Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes. RESULTS: Gene families across yeast were constructed for each member of the pathway and the ratio of nonsynonymous to synonymous nucleotide substitution rates (d
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Berlin, Sofia. "The Effects of Mutation and Selection on the Rate and Pattern of Molecular Evolution in Birds." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4516.

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Jung, Matthieu. "Evolution du VIH : méthodes, modèles et algorithmes." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20052/document.

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La donnée de séquences nucléotidiques permet d'inférer des arbres phylogénétiques, ou phylogénies, qui décrivent leur lien de parenté au cours de l'évolution. Associer à ces séquences leur date de prélèvement ou leur pays de collecte, permet d'inférer la localisation temporelle ou spatiale de leurs ancêtres communs. Ces données et procédures sont très utilisées pour les séquences de virus et, notamment, celles du virus de l'immunodéficience humaine (VIH), afin d'en retracer l'histoire épidémique à la surface du globe et au cours du temps. L'utilisation de séquences échantillonnées à des moment
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Axelsson, Erik. "Comparative Genomics in Birds." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7432.

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Saclier, Nathanaëlle. "Origine des variations de taux d’évolution moléculaire inter-spécifiques : apport d’un modèle génomique en milieu souterrain." Thesis, Lyon, 2019. https://n2t.net/ark:/47881/m69p310z.

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La vitesse à laquelle les séquences d’ADN évoluent varie selon les espèces. Ces différences peuvent venir de caractéristiques intrinsèques de l’espèce (taux métabolique, traits d’histoire de vie) ou de son environnement (rayonnements ionisants). L’objectif de cette thèse est de tester les principales hypothèses expliquant les variations de taux d’évolution moléculaire entre les espèces. Pour cela, les particularités des Asellidae souterrains ont été couplées avec des données de séquençage nouvelle génération dans le génome nucléaire et le génome mitochondrial. L’utilisation des Asellidae comme
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Erixon, Per. "Phylogenetic Support and Chloroplast Genome Evolution in Sileneae (Caryophyllaceae)." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7166.

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Künstner, Axel. "Birds as a Model for Comparative Genomic Studies." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159766.

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Comparative genomics provides a tool to investigate large biological datasets, i.e. genomic datasets. In my thesis I focused on inferring patterns of selection in coding and non-coding regions of avian genomes. Until recently, large comparative studies on selection were mainly restricted to model species with sequenced genomes. This limitation has been overcome with advances in sequencing technologies and it is now possible to gather large genomic data sets for non-model species.  Next-generation sequencing data was used to study patterns of nucleotide substitutions and from this we inferred h
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Books on the topic "Substitution rate evolution"

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Renner, Tanya, Tianying Lan, Kimberly M. Farr, et al. Carnivorous plant genomes. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198779841.003.0011.

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Carnivorous plant genome research has focused on members of the Lamiales and Oxalidales; the most complete sequences are for Utricularia gibba and Cephalotus follicularis. The size-limited U. gibba genome highlights the importance of small-scale tandem duplications, which likely play roles in this species’ carnivorous adaptation. Sequencing of the C. follicularis genome detected adaptive changes that may explain the evolution of traits associated with attraction, trapping, digestion, and absorption. Functional consequences of genes putatively missing in the U. gibba genome, yet present in othe
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Pamuk, Sevket. Uneven Centuries. Princeton University Press, 2018. http://dx.doi.org/10.23943/princeton/9780691166377.001.0001.

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The population and economy of the area within the present-day borders of Turkey has consistently been among the largest in the developing world, yet there has been no authoritative economic history of Turkey until now. This book examines the economic growth and human development of Turkey over the past two hundred years. Taking a comparative global perspective, the book investigates Turkey's economic history through four periods: the open economy during the nineteenth-century Ottoman era, the transition from empire to nation-state that spanned the two world wars and the Great Depression, the c
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Book chapters on the topic "Substitution rate evolution"

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Hu, Ting, and Wolfgang Banzhaf. "Nonsynonymous to Synonymous Substitution Ratio $k_{\mathrm a}/k_{\mathrm s}$ : Measurement for Rate of Evolution in Evolutionary Computation." In Parallel Problem Solving from Nature – PPSN X. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-87700-4_45.

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Muse, Spencer V. "Examining rates and patterns of nucleotide substitution in plants." In Plant Molecular Evolution. Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4221-2_2.

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Conference papers on the topic "Substitution rate evolution"

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Hu, Ting, and Wolfgang Banzhaf. "Measuring rate of evolution in genetic programming using amino acid to synonymous substitution ratioka/ks." In the 10th annual conference. ACM Press, 2008. http://dx.doi.org/10.1145/1389095.1389352.

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Aniello, Andrea, Lorenzo Bartolucci, Stefano Cordiner, Vincenzo Mulone, Sundar R. Krishnan, and Kalyan K. Srinivasan. "CFD Analysis of Diesel-Methane Dual Fuel Low Temperature Combustion at Low Load and High Methane Substitution." In ASME 2018 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icef2018-9649.

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Over the last few decades, emissions regulations for internal combustion engines have become increasingly restrictive, pushing researchers around the world to exploit innovative propulsion solutions. Among them, the dual fuel low temperature combustion (LTC) strategy has proven capable of reducing fuel consumption and while meeting emissions regulations for oxides of nitrogen (NOx) and particulate matter (PM) without problematic aftertreatment systems. However, further investigations are still needed to reduce engine-out hydrocarbon (HC) and carbon monoxide (CO) emissions as well as to extend
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