Journal articles on the topic 'Substance abuse – Treatment – Cross-cultural studies'

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1

Lo, T. Wing, Jerf W. K. Yeung, and Cherry H. L. Tam. "Substance Abuse and Public Health: A Multilevel Perspective and Multiple Responses." International Journal of Environmental Research and Public Health 17, no. 7 (April 10, 2020): 2610. http://dx.doi.org/10.3390/ijerph17072610.

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Substance abuse has been a thorny public health concern throughout human history. Manifestly, prevention and treatment are the two main strategies commonly adopted to tackle the problem of substance abuse. They are in fact cross-disciplinary, and they relate to the various domains of heredity, biology, psychology, cognitive science, family, social development and cultural structures. This special issue, “Substance Abuse, Environment and Public Health,” has published empirical studies from different regions and countries globally to enhance the international exchange of latest views and findings on the etiology, processes and influences of substance abuse across different domains, through which a multilevel perspective is considered more helpful for analyzing its complex nature, courses and consequences. This in turn suggests the possible need to employ multiple responses dynamically and integratively in the prevention and treatment of substance abuse.
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Karadag, F. "Posttraumatic Disorders in Patients with Substance Dependence: Dissociative Disorders and Substance Dependence." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70478-x.

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There are limited number of studies about dissociative disorders and substance abuse/dependence. Ross et al (1992) found that 39.0% of 100 chemically dependent patients had a dissociative disorder. Dunn et al (1995) found that this rate was 15.0% for 100 patients with substance use disorder at the end of their inpatient treatment. In the third study, 215 consecutive inpatients were recruited. The prevalence of the DSM-IV dissociative disorders was 17.2%. 67.6% of these patients’ dissociative experiences had started 3.6 (SD=2.9, range: 1.0-11.0) years before onset of the substance use in average. Patients with dissociative disorder were younger and average duration of their remission periods was shorter. Dissociative patients tended to use more than one substance whereas drugs were used more frequently than alcohol in this group. The frequency of borderline personality disorder, somatization disorder, history of suicide attempt, and childhood abuse and neglect in this qroup was more than that in the non-dissociative group. Suicide attempt, female gender, and childhood emotional abuse were significant predictors of a dissociative disorder diagnosis. Significantly more patients with dissociative disorder stopped their treatment prematurely. These findings suggest that dissociative disorder comorbidity is not a phenomenon limited to a cross-sectional observation and to a crisis period, but it is involved in all phases of substance dependency and it may have tremendous impact on the course and treatment outcome of the process.
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Jelti, A., F. Kennab, F. N’Sabi, B. Oneib, and F. Elghazouani. "Psychiatric comorbidity among patients attending an addiction treatment center in Morocco." European Psychiatry 65, S1 (June 2022): S833. http://dx.doi.org/10.1192/j.eurpsy.2022.2157.

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Introduction The comorbidity between psychiatric disorders and substance use disorders is more and more common in daily clinical practice. However, only few studies have adressed this subject in north african patients. Objectives The main objective of our study was the estimation of the prevalence and patterns of psychiatric co-morbidities in substance users seeking care. Methods Our work consisted of a cross-sectional study of a sample of patients attending outpatient substance use treatment at the addiction center in Oujda, Morocco. A hetero-questionnaire was used to collect sociodemographic data and patient history, DSM-IV criteria to assess substance abuse and dependence, and the Mini-International Neuropsychiatric Interview [MINI] to assess psychiatric comorbidities. Results Our study involved 100 patients, with a male predominance (89% of users). The main substances used in the last 12 months were tobacco (78%), followed by cannabis (74%), alcohol (50%), and benzodiazepines (44%). Psychiatric comorbidity was identified in 71% of the users, 51% of whom had a depressive disorder, 35% an anxiety disorder and 10% a gambling disorder. The dependence on the substance that initially motivated the consultation was higher in patients with psychiatric comorbidity (p=0.033). The post-traumatic stress disorder was significantly associated with the presence of alcohol dependence (p=0.028). The presence of benzodiazepine dependence (p=0.025) and abuse of cocaine (p=0.028) and Ecstasy (p=0.000) were significantly associated with suicide risk. Conclusions Our study found a high prevalence of psychiatric comorbidities among substance users seeking treatment, this should prompt clinicians to pay particular attention to this issue in order to adapt and improve their management. Disclosure No significant relationships.
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PLATT, JEROME J., MINDY WIDMAN, VICTOR LIDZ, DAVID RUBENSTEIN, and ROBERT THOMPSON. "The Case for Support Services in Substance Abuse Treatment." American Behavioral Scientist 41, no. 8 (May 1998): 1050–62. http://dx.doi.org/10.1177/0002764298041008003.

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5

Amaro, Hortensia, Rita Nieves, Sergut Wolde Johannes, and Nirzka M. Labault Cabeza. "Substance Abuse Treatment: Critical Issues and Challenges in the Treatment of Latina Women." Hispanic Journal of Behavioral Sciences 21, no. 3 (August 1999): 266–82. http://dx.doi.org/10.1177/0739986399213005.

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6

Santos, Mariana, Diego Travi, Camila Ribeiro, Thiago Pianca, Indara Saccilotto, Lúcia Silla, and Paulo Picon. "PP013 Pain Management And Substance Abuse In Sickle Cell Disease Patients." International Journal of Technology Assessment in Health Care 33, S1 (2017): 73–74. http://dx.doi.org/10.1017/s0266462317002057.

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INTRODUCTION:Drug abuse is a social and public health problem because of its negative consequences of emotional and physical development in individuals. There are few studies evaluating substance abuse by individuals with sickle cell disease (SCD). These patients have severe and recurrent pain crises (1), frequently needing opioids to control it (2). The compromised quality of life can predispose this population to the occurrence of non-psychotic disorders such as depression, making them vulnerable to substance abuse (3).METHODS:We evaluated the consumption of alcohol and drugs in a cohort followed at the Sickle Cell Disease Reference Center (CRAF), at Hospital de Clínicas de Porto Alegre, estimating the percentage of patients in treatment of SCD who abuse alcohol and drugs, mainly opioids. A cross-sectional study was of a convenience sample of 139 patients with SCD treated at CRAF. The pattern of substance use was evaluated using the Brazilian version of Alcohol, Smoking and Substance Involvement Screening Test (ASSIST). The exposure to opioids was measured by their use and prescription in the 24 months before the interview. The Self-Reporting Questionnaire (SRQ-20) was used to estimate the occurrence of non-psychotic disorders in this population. Descriptive analyses were performed using absolute and relative frequencies. The association between the variables was verified using the chi-square test or Fisher's exact test.RESULTS:The prevalence of abusive use was 1.5 percent for alcohol and 3.0 percent for tobacco, with no abusive use of any other substance including opioids was identified. Of note was the pattern for substance use that was not influenced by exposure to substances or the presence of non-psychotic disorders.CONCLUSIONS:Our data shows that use of opioid analgesics for the management of SCD painful crises is safe and does not induce substance abuse. Regular follow-up of these patients is recommended. The results of this study might be useful in other countries.
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Camargo-Júnior, Elton Brás, Maria Neyrian de Fátima Fernandes, and Edilaine Cristina da Silva Gherardi-Donato. "Echoes of early-life stress on suicidal behavior in individuals with substance use disorder." Enfermería Actual en Costa Rica, no. 44 (January 2, 2023): 1–15. http://dx.doi.org/10.15517/enferm.actual.cr.i44.48972.

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Introduction: Psychoactive substances abuse is considered a problematic social factor due its likelihood to cause harmful, self-destructive behaviors to the subjects and the overall society. Stress in an individual's early life may also be a contributing factor to substance abuse as well as suicide attempts. There is a lack of studies examining these factors in people with substance-use disorder. Aim: to identify the relationship between early-life stress and suicide attempts in drug-dependent adults. Methods: This is a predictive correlational study with a cross-sectional approach. The convenience sample consisted of 105 individuals treated at an outpatient unit for addiction treatment. The participants were assessed using the Mini-international Neuropsychiatric Interview, a Childhood Trauma Questionnaire to measure the severity of the different types of early life stress; the Beck Scale for Suicide Ideation was also used. The data were analyzed using descriptive and inferential statistics through univariate and multivariate logistic regression. Results: The analyzed sample included 33 (31.4%) individuals who attempted suicide and were significantly more likely to suffer from emotional, physical, or sexual abuse than those who had never attempted suicide (p <0,05). Conclusions: Different forms of early-life stress are related to attempted suicide in people with substance-use disorder. Further studies are needed to understand the effects of early-life stress on suicide attempts in drug-dependent people.
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BAKER, PHYLLIS L., and AMY CARSON. "“I TAKE CARE OF MY KIDS”." Gender & Society 13, no. 3 (June 1999): 347–63. http://dx.doi.org/10.1177/089124399013003005.

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This article examines 17 substance-abusing women's perceptions of their mothering practices in the context of a residential substance-abuse treatment program for women with children and pregnant women. Using in-depth semistructured interviews and observations of treatment groups, the participants' cultural knowledge about mothering is explored. Although the women in this study described how their substance-abusing lifestyle had a negative impact on their children, they also detailed practices that illustrated that they felt capable as parents. The women were silent about how race, gender, or class arrangements affected their lives; their stories, however, showed active avoidance and manipulation of the contemporary ideology of mothering.
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Bøhle, Kari, Eli Otterholt, and Stål Bjørkly. "Protective Factors Against Psychological Distress Among Inpatients in Substance Use Treatment: A Cross-Sectional Study." Substance Abuse: Research and Treatment 15 (January 2021): 117822182110608. http://dx.doi.org/10.1177/11782218211060848.

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Several studies have found co-occurrence between substance abuse and mental health problems, as well as an association between treatment retention and psychological distress. The aim of this study was to investigate the association of possible protective factors with psychological distress. The present study tested physical activity, self-esteem and sense of coherence, and psychological distress level among inpatients in substance use treatment. The study design was cross-sectional and multicenter. Patients (N = 167) were recruited in 2018 from 10 Norwegian inpatient facilities. They self-reported on 3 validated measurement instruments: Rosenberg Self-Esteem Scale, Antonovsky’s Sense of Coherence Scale, and frequency of physical activity. The Hopkins Symptom Checklist-10 was used as an outcome variable of psychological distress. The associations were investigated with multiple linear and logistic regression methods. The results suggested that high self-esteem and sense of coherence were protective factors against high levels of psychological distress: self-esteem (β = −.39, P < .001) and sense of coherence (β = −.352, P < .001). The results offer support for a salutogenic approach in substance use disorder (SUD) treatment by enhancing individuals’ protective factors to reduce psychological distress.
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10

Cummings, Nicholas A. "Inpatient versus outpatient treatment of substance abuse: Recent developments in the controversy." Contemporary Family Therapy 13, no. 5 (October 1991): 507–20. http://dx.doi.org/10.1007/bf00890501.

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11

Reitan, Therese. "Patterns of polydrug use among pregnant substance abusers." Nordic Studies on Alcohol and Drugs 34, no. 2 (March 30, 2017): 145–59. http://dx.doi.org/10.1177/1455072516687256.

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Aim: Studies of drug use during pregnancy have generally focused on individual substances or specific combinations of drugs. The aim of this article is to increase our knowledge about polydrug use and pregnancy in a Nordic context by describing the sociodemographic characteristics of a clinical population of pregnant women with severe substance use, examining the scope and type of polydrug use and analysing factors associated with concurrent use of many, as opposed to a few, drugs. Method: A cross-sectional study of pregnant women on admission to compulsory care for substance abuse in Sweden between 2000 and 2009 ( n = 119 women, representing 128 pregnancies). Data were retrieved from administrative registers and client records. Univariate links between demographic, social, obstetrical, treatment history variables and polydrug use were examined. Binary logistic regression was used to analyse the association between explanatory variables and polydrug use. Results: The average number of drugs being used concurrently was 2.65, and injection drug use was recorded in 73% of the pregnancies. Opiates and amphetamines were the most common primary drugs, followed by alcohol. The likelihood of polydrug use increased with first trimester pregnancy, planned (as opposed to emergency) committals, as well as the combination of partner substance abuse and injection drug use. Conclusions: Polydrug use was widespread among pregnant substance abusers. Policies, interventions and research often focus on individual drugs separately, but for clinical populations in particular there is a need to address drug use broadly, including a systematic recording of smoking habits. This also entails awarding more attention to those not eligible for established interventions, such as opiate maintenance treatment, and giving more consideration to a variety of life circumstances, such as partner drug use.
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Gual, A., H. López-Pelayo, P. Bruguera, and L. Miquel. "Sodium Oxybate: a Substitute for Alcohol?" European Psychiatry 65, S1 (June 2022): S42. http://dx.doi.org/10.1192/j.eurpsy.2022.144.

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Gamma-hydroxybutyrate (GHB) is a neurotransmitter found naturally in the human brain. Sodium oxybate (SO) is the sodium salt of GHB. In 2000 GHB was classified a Schedule I controlled substance, while SO became a Schedule III controlled substance for medicinal use under the Controlled Substances Act. SO and alcohol share a similar pharmacological profile. GHB acts on GABAB receptors and extrasynaptic GABAA receptors resulting in alcohol-mimetic effects in several CNS actions. It substitutes the discriminative stimulus effects of alcohol in rats, and has cross tolerance with alcohol. All together, this leads to think of SO as a substitution therapy for alcohol use disorders. SO was initially studied in the prevention of alcohol withdrawal, and it showed similar efficacy to benzodiacepines. The studies on relapse prevention were developed later and the results are mixed and more complex to understand. While open label studies show a positive effect, RCTs have not been able to show a significant effect for the whole sample. Nevertheless, post-hoc analysis show a robust effect in the subsample of patients with high risk drinking levels, that would be the preferred target for a substitution treatment. The potential for abuse of GHB is well documented, which should be no surprise for a substitution treatment. Nevertheless, when correctly prescribed the risk of abuse of SO remains very low, as shown both in clinical trials and in the pharmacovigilance database, with more than 260000 cases documented. SO can be considered a substitution treatment, effective in patients with high risk drinking levels. Disclosure I was investigator in the SMO study on sodium oxybate, funded by D&A Pharma.
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Vilela, Fabiana Andrioni De Biaze, Flávia Serebrenic Jungerman, Ronaldo Laranjeira, and Russel Callaghan. "The transtheoretical model and substance dependence: theoretical and practical aspects." Revista Brasileira de Psiquiatria 31, no. 4 (November 13, 2009): 362–68. http://dx.doi.org/10.1590/s1516-44462009005000010.

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OBJECTIVE: This paper aims to present and discuss the Transtheoretical Model and its importance for the treatment of substance abuse disorders. METHOD: A literature review was made based on articles from the last 10 years in substance use with human subjects found in PubMed (Medline) and the Scientific Electronic Library Online, as well as on the main books written by the creators of the model. From the initial collection of articles related to the Transtheoretical Model, the University of Rhode Island Assessment and substance abuse, those related to other health conditions were excluded. Although articles related to hospitalization were also excluded, as were those related to the Minnesota Model, treatment proposals were included. RESULTS: Although the TTM has been studied for over 20 years, new concerns regarding the initial idea continue to arise. Such concerns include the cross-sectional design of studies employing the model, as well as the prescriptive versus descriptive point of view. DISCUSSION: The review of the Transtheoretical Model brought intentional behavior change to light, which could broaden the understanding of addictive behaviors. Together with its concepts of processes and stages of change, the Transtheoretical Model provides professionals with the idea that the effectiveness of therapy is dependent upon the capability of the therapist to match the technique to the current motivational stage of the patient in the process of change. This demonstrates the importance of identifying the stage of change of the patient when they present for treatment. Here, we describe the principal elements of the Transtheoretical Model, as well as the instruments currently used to identify the stage of change. Finally, criticisms and limitations of the model are discussed.
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McFadden, John. "Guilt is Soluble in Alcohol: An Ego Analytic View." Journal of Drug Issues 17, no. 2 (April 1987): 171–86. http://dx.doi.org/10.1177/002204268701700204.

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Ego analysis, a version of Freudian theory, maintains that guilt is a sufficient cause of substance abuse. A cultural analysis reveals that self-negation is powerfully reinforced in technologically advanced societies by an unexamined moralistic belief system. In the field of alcoholism, the psychoanalytic perspective is opposed primarily by two arguments. First, researchers argue that psychodynamic factors cannot account for abuse because longitudinal studies demonstrate that symptoms of mental illness are not evident either before or after the abuse careers of many sufferers. Second, cognitive behaviorists maintain that the concept “maladaptive expectancies” explains addictions more adequately than psychodynamic theories. Freud's discovery that unconscious guilt can drive even normal people to antisocial behavior is the basis for disputing both arguments. The ego analyst's therapeutic alternative is contrasted with the conventional, abstinence-only approach and cognitive-behavioral treatment.
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McCaughrin, William C., and Daniel L. Howard. "Variation in Outpatient Substance Abuse Treatment Units with High Concentrations of Latino Versus White Clients: Client Factors, Treatment Experiences, and Treatment Outcomes." Hispanic Journal of Behavioral Sciences 17, no. 4 (November 1995): 509–22. http://dx.doi.org/10.1177/07399863950174007.

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Senreich, Evan. "Inviting the Significant Other of LGBT Clients into Substance Abuse Treatment Programs: Frequency and Impact." Contemporary Family Therapy 32, no. 4 (September 18, 2010): 427–43. http://dx.doi.org/10.1007/s10591-010-9133-3.

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Kennedy, Sidney H., and Paul E. Garfinkel. "Advances in Diagnosis and Treatment of Anorexia Nervosa and Bulimia Nervosa*." Canadian Journal of Psychiatry 37, no. 5 (June 1992): 309–15. http://dx.doi.org/10.1177/070674379203700504.

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This paper reviews four areas of research into anorexia nervosa (AN) and bulimia nervosa (BN). First, in terms of diagnosis, the psychological concerns about weight and shape are now addressed in BN, bringing it more in line with the related disorder, anorexia nervosa. Second, studies of psychiatric comorbidity confirm the overlap between eating disorders and depression, obsessive compulsive disorder, substance abuse, and personality disorder. Nevertheless, there are reasons to accept the distinct qualities of each syndrome, and eating disorders are not merely a variant of these other conditions. Third, treatment advances in BN involve mainly cognitive-behavioural or interpersonal psycho-therapies and pharmacotherapies primarily with antidepressants. The effect of combining more than one approach is beginning to be addressed. Finally, outcome studies involving people with both AN and BN have shown that the disorders “cross over” and that both conditions have a high rate of relapse. A renewed interest in the treatment of AN is needed.
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Kopak, Albert M., and Bethany Van Brown. "Substance Use in the Life Cycle of a Disaster: A Research Agenda and Methodological Considerations." American Behavioral Scientist 64, no. 8 (July 2020): 1095–110. http://dx.doi.org/10.1177/0002764220938109.

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Considering the increasing frequency and magnitude of natural and human-made disasters, it is becoming more important to understand human responses to these events, including the ways they influence substance use. The Substance Abuse and Mental Health Service Administration has recently acknowledged that the prevention and treatment of substance use disorders must be incorporated into disaster preparedness, response, and recovery, but there is a scarcity of empirical information related to how these approaches should be undertaken. This article provides an overview of prior work in this area to inform a broad, but nuanced research agenda. That agenda is organized according to key findings and various strategies that can identify, measure, and assess substance use in various stages of the life cycle of a disaster. We conclude with recommendations for policies that can enhance the research in this area while also informing the development of practices to monitor substance use disorders related to various disasters.
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Kimmel, James, and Michael Rowe. "A Behavioral Addiction Model of Revenge, Violence, and Gun Abuse." Journal of Law, Medicine & Ethics 48, S4 (2020): 172–78. http://dx.doi.org/10.1177/1073110520979419.

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Data from multiple sources point to the desire for revenge in response to grievances or perceived injustices as a root cause of violence, including firearm violence. Neuroscience and behavioral studies are beginning to reveal that the desire for revenge in response to grievances activates the same neural reward-processing circuitry as that of substance addiction, suggesting that grievances trigger powerful cravings for revenge in anticipation of experiencing pleasure. Based on this evidence, the authors argue that a behavioral addiction framework may be appropriate for understanding and addressing violent behavior. Such an approach could yield significant benefits by leveraging scientific and public health-oriented drug abuse prevention and treatment strategies that target drug cravings to spur development of scientific and public-health-oriented “gun abuse” prevention and treatment strategies targeting the revenge cravings that lead to violence. An example of one such “motive control” strategy is discussed. Approaching revenge-seeking, violence, and gun abuse from the perspective of compulsion and addiction would have the added benefit of avoiding the stigmatization as violent of individuals with mental illness while also acknowledging the systemic, social, and cultural factors contributing to grievances that lead to violent acts.
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Fischer, Benedikt. "Prevalence of Pain Among Nonmedical Prescription Opioid Users in Substance Use Treatment Populations: Systematic Review and Meta-analyses." Pain Physician 6;16, no. 6;11 (November 14, 2013): E671—E684. http://dx.doi.org/10.36076/ppj.2013/16/e671.

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Background: Prescription opioid analgesics (POA) are widely used in the pharmacotherapeutic treatment of acute and chronic pain in North America, where nonmedical prescription opioid use (NMPOU) has become a substantial public health concern in recent years. Existing epidemiological data suggest an association between NMPOU and pain problem symptoms in different populations, including samples in substance use treatment, although the extent of these correlations has not been systematically assessed. Objective: To systematically review and meta-analyze the prevalence of pain symptoms or problems among populations reporting NMPOU in substance use treatment. Study Design: Systematic review and meta-analyses. Methods: A systematic review and meta-analyses were conducted for pain symptoms in substance use treatment samples reporting NMPOU within the last 30 days or at admission to treatment. Overall, 8 unique epidemiological studies were identified and included in the meta-analyses; in 7 of these samples POAs were the primary drug and/or POA dependence was reported. Results: The pooled prevalence of pain in all NMPOU samples in substance use treatment was 58% (95% confidence interval [CI]: 53%–64%). The pooled prevalence of pain in the studies with POAs as the primary drug and/or POA dependence was 60% (95% CI: 52%–67%), and the prevalence of pain with “any” POA abuse (n = 2 studies) was 50% (95% CI: 40%–60%). Limitations: A small number of studies were available and included in the review; these were restricted to cross-sectional datasets only. Statistical heterogeneity was found in the metaanalytical results. Conclusions: Pain symptoms are disproportionately elevated in substance use treatment samples reporting NMPOU. Effective measures to prevent and treat NMPOU are urgently needed, although a substantive extent of NMPOU observed in this specific context may relate directly or indirectly to the presence of pain, e.g., either as an expression of ineffective pain care or as a consequence of previous POA-based interventions. At the same time, effective ways to treat and address ongoing pain issues in NMPOU samples need to be implemented, which may require ongoing opioid-based pharmacotherapeutic care aimed at both pain and dependence. Key words: Prescription opioids, nonmedical use, dependence, pain, comorbidity, substance use treatment, prevention, systematic review, meta-analyses.
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Withy, Kelley M., Wayde Lee, and Ralph F. Renger. "A Practical Framework for Evaluating a Culturally Tailored Adolescent Substance Abuse Treatment Programme in Molokai, Hawaii." Ethnicity & Health 12, no. 5 (November 1, 2007): 483–96. http://dx.doi.org/10.1080/13557850701616920.

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Frøkedal, Hilde, Torgeir Sørensen, Torleif Ruud, Valerie DeMarinis, and Hans Stifoss-Hanssen. "Addressing the existential dimension in treatment settings: Mental health professionals’ and healthcare chaplains’ attitudes, practices, understanding and perceptions of value." Archive for the Psychology of Religion 41, no. 3 (November 2019): 253–76. http://dx.doi.org/10.1177/0084672419883345.

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Research has shown that addressing and integrating the existential dimension in treatment settings reduce symptoms like anxiety, depression and substance abuse. Healthcare chaplains are key personnel in this practice. A nationwide, cross-sectional survey influenced by a mixed-methods approach was used to examine the attitudes, practices, understanding and perceptions of mental health professionals, including healthcare chaplains, regarding the value of addressing the existential dimension in treatment programmes. The existential group practice was led by the healthcare chaplains as an integrated part of specialist mental health services. A positive and open attitude towards addressing the existential dimension was identified among the informants. Despite this, a small gap between attitude and practice was reported. Existential, religious and spiritual concerns are reported as part of the existential dimension and as relevant topics to be discussed in specialist mental health services. The findings indicate that the existential group practice could have a positive influence on the co-leaders’ competence to address existential, religious and spiritual concerns; however, this should be further investigated.
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Bazargan-Hejazi, Shahrzad, Valory De Lucia, Deyu Pan, Mona Mojtahedzadeh, Elham Rahmani, Sinan Jabori, Golara Zahmatkesh, and Mohsen Bazargan. "Gender Comparison in Referrals and Treatment Completion to Residential and Outpatient Alcohol Treatment." Substance Abuse: Research and Treatment 10 (January 2016): SART.S39943. http://dx.doi.org/10.4137/sart.s39943.

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Background Residential treatment for alcoholism is associated with high completion rates for clients, yet there appear to be gender disparities in patient referrals and treatment completion rates. We studied whether (A) gender is associated with differential patient placement to outpatient vs. residential treatment facilities and (B) completion rates differ by gender. Methods In this cross-sectional study, we analyzed the admission and discharge data from 185 publicly funded substance abuse treatment facilities across Los Angeles County between 2005 and 2010. Results Among the 33,745 studied cases, women were referred to residential treatment facilities less frequently than men (75% vs. 66%). The adjusted results derived from logistic regression models confirmed that females were more likely to be referred to outpatient treatment than to residential treatment facilities (odds ratio [OR]: 1.15, 95% confidence interval [CI]: 1.05–1.26). In addition, we observed that compared to White/Caucasian patients, all other races were associated with more referral to outpatient facilities (ie, less referral to residential facilities), indicating a racial disparity on the top of the observed gender disparity. However, there was no significant link between gender and treatment completion rates (OR: 0.93, 95% CI: 0.86–1.00). Conclusions Women seem to have treatment completion rates comparable to men, yet they are less likely to be referred to residential treatment facilities. Hence, there still remains a gender disparity in alcoholic patient referrals. Further studies should delineate which specific therapeutic aspects and programmatic components of women-focused treatments are essential to augment positive treatment outcomes.
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Majeed, Muhammad Hassan, Ali Ahsan Ali, and Donna M. Sudak. "Psychotherapeutic interventions for chronic pain: Evidence, rationale, and advantages." International Journal of Psychiatry in Medicine 54, no. 2 (August 9, 2018): 140–49. http://dx.doi.org/10.1177/0091217418791447.

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Background Long-term use of opioids to treat chronic pain incurs serious risks for the individual—including misuse, abuse, addiction, overdose and death—as well as creating economic, social, and cultural impacts on society as a whole. Chronic pain and substance use disorders are often co-morbid with other medical problems and at the present time, primary care clinicians serve most of this population. Primary care clinicians would benefit from having alternatives to opioids to employ in treating such patients. Method We electronically searched different medical databases for studies evaluating the effect of nonpharmacological treatments for chronic pain. We describe alternative approaches for the treatment of chronic pain and cite studies that provide substantial evidence in favor of the use of these treatments. Results Cognitive behavioral therapy, acceptance and commitment therapy, and mindfulness-based programs have well-documented effectiveness for the treatment of chronic nonmalignant pain. Integration of such behavioral health therapies into primary care settings may optimize health resources and improve treatment outcomes. Conclusion Evidence-based psychotherapy for chronic pain has established efficacy and safety and improves quality of life and physical and emotional functioning. Such interventions may be used as an alternative or adjunct to pharmacological management. Chronic opioid use should be reserved for individuals undergoing active cancer treatment, palliative care, or end-of-life care.
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ZIMMERMANN, P., H. U. WITTCHEN, M. HÖFLER, H. PFISTER, R. C. KESSLER, and R. LIEB. "Primary anxiety disorders and the development of subsequent alcohol use disorders: a 4-year community study of adolescents and young adults." Psychological Medicine 33, no. 7 (September 25, 2003): 1211–22. http://dx.doi.org/10.1017/s0033291703008158.

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Background. Cross-sectional findings in community surveys of adults suggest that adolescent anxiety disorders are strong predictors of the subsequent onset of alcohol use, abuse and dependence. However, prospective data that follow a sample of adolescents into adulthood are needed to confirm these associations.Method. Baseline and 4-year follow-up data from the EDSP-Study, a prospective community survey of 3021 (2548 at follow-up) adolescents and young adults aged 14 to 24 years at baseline carried out in Munich, were used. DSM-IV anxiety disorders, alcohol use and alcohol use disorders were assessed with the Munich-Composite-International-Diagnostic-Interview (M-CIDI). Multiple logistic regression analysis, controlling for age, gender, other mental disorders, substance use disorders and antisocial behaviour was used to study the associations of baseline anxiety disorders with the subsequent onset and course of alcohol use and alcohol disorders.Results. Baseline social phobia significantly predicts the onsets of regular use and hazardous use and the persistence of dependence. Panic attacks significantly predict the onsets of hazardous use and abuse as well as the persistence of combined abuse/dependence. Panic disorder significantly predicts the persistence of combined abuse/dependence. Other anxiety disorders do not significantly predict any of the outcomes.Conclusions. Panic and social phobia are predictors of subsequent alcohol problems among adolescents and young adults. Further studies are needed to investigate the underlying mechanisms and the potential value of targeted early treatment of primary panic and social phobia to prevent secondary alcohol use disorders.
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Schouler-Ocak, M., and E. J. Brandl. "The Impact of Violence and Abuse on Mental Health of Women – Current Data." European Psychiatry 65, S1 (June 2022): S37. http://dx.doi.org/10.1192/j.eurpsy.2022.130.

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Violence against women is widely recognised as a violation of human rights and a public health problem. The most common forms of violence against women are domestic abuse and sexual violence, and victimisation is associated with an increased risk of mental disorders. It is reported that a three times increase in the likelihood of depressive disorders, a four times increase in the likelihood of anxiety disorders, and a seven times increase in the likelihood of post-traumatic disorder (PTSD) for women who have experienced domestic violence and abuse. Significant associations between intimate partner violence and symptoms of psychosis, substance misuse, and eating disorders have also been reported. Furthermore, systematic reviews of predominantly cross-sectional studies report consistent relationships between being a victim of domestic violence and abuse and having mental disorders across the diagnostic spectrum for men and women, but since women are more likely to be victims, the population attributable fractions are higher for women. In this presentation, the focus will also be on clinical guidance on the role of mental health professionals in identifying violence against women and responding appropriately, poor identification persists and can lead to non-engagement with services and poor response to treatment. After a literature review, we will present and discuss current data from parental consultation and a survey on violence during the Covid-19 pandemic in Berlin. Disclosure No significant relationships.
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Kour, Prabhjot, Lars Lien, Bernadette Kumar, Stian Biong, and Henning Pettersen. "Treatment Experiences with Norwegian Health Care among Immigrant Men Living with Co-Occurring Substance Use- and Mental Health Disorders." Substance Abuse: Research and Treatment 14 (January 2020): 117822182097092. http://dx.doi.org/10.1177/1178221820970929.

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Immigrants are considered at risk of psychological distress and therefore involvement in substance abuse, due to a variety of pre- and post-migration factors. Further, there is lower treatment engagement, a higher dropout rate, and less frequent hospitalizations among this group compared to the general population. There are few studies on the subjective understanding of co-occurring substance use disorder (SUD) and mental health disorder (MHD) among immigrants in Norway. This qualitative study aims to explore the treatment experiences of immigrant men living with co-occurring SUD and MHD. Within a collaborative approach, individual interviews were conducted with 10 men of immigrant background, living with co-occurring SUD and MHD, who had treatment experiences from the Norwegian mental health and addiction services. Data were analyzed using a systematic text condensation. The analysis yielded 6 categories where participants described their treatment experiences in mental health and addiction services in Norway as: lack of connection, lack of individually tailored treatment, stigma and discrimination preventing access to treatment, health professionals with multi-cultural competence, care during and after treatment, and raising awareness and reducing stigma. A significant finding was the mention by participants of the value of being seen and treated as a “person” rather than their diagnosis, which may increase treatment engagement. They further mentioned aftercare as an important factor to prevent relapse. This study provides an enhanced understanding of how immigrant men living with co-occurring SUD and MHD experienced being treated in Norwegian healthcare settings. These experiences may add to the knowledge required to improve treatment engagement.
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Serafini, G., C. Conigliaro, F. Pittaluga, M. Pompili, P. Girardi, and M. Amore. "Childhood Traumatic Experiences and Coping Strategies: Correlations With Quality of Life." European Psychiatry 41, S1 (April 2017): S210. http://dx.doi.org/10.1016/j.eurpsy.2017.01.2176.

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IntroductionIndividuals with a history of childhood traumatic experiences may exert maladaptive coping strategies and impaired adult quality of life.ObjectivesThe present study explored the association between childhood traumatic experiences, coping strategies, and quality of life.AimsWe aimed to evaluate whether childhood traumatic experiences or specific coping strategies may significantly predict quality of life.MethodsThis is a cross-sectional study including 276 patients (19.9% men, 81.1% women; mean age: 48.1 years, SD: 16.9), of which most with major affective disorders, who were recruited at the psychiatric unit of the university of Genoa (Italy). All participants were assessed using the Childhood Trauma Questionnaire (CTQ), Coping Orientation to Problems Experienced (Cope), and Short Form 12 Health Survey version 2 (SF-12).ResultsSubjects with a history of emotional abuse were more likely to have an earlier age of onset of their psychiatric conditions, an earlier age of their first treatment/hospitalization, higher recurrent episodes and days of hospitalization, longer illness duration and non-psychiatric treatments at intake when compared with those who did not present any history of abuse. Based on regression analyses, only positive reinterpretation and growth, focus on and venting of emotions, and substance abuse, but not childhood traumatic experiences, resulted positive predictors of physical quality of life. Moreover, focus on and venting of emotions was able to predict mental quality of life.ConclusionsWhile traumatic experiences did not predict quality of life, specific coping strategies were significant predictors of quality of life. Further studies are requested to test these preliminary results.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Sapkota, Shabal, Mitesh Karn, Bhoj Raj Neupane, Bandana Gurung, Chandika Pandit, Tirtha Upadhyay, Brihaspati Sigdel, and Dipendra Kandel. "Factors predicting leaving against medical advice in Neurosurgery: A prospective observational study from Nepal." Nepal Journal of Neuroscience 19, no. 2 (July 7, 2022): 17–24. http://dx.doi.org/10.3126/njn.v19i2.43168.

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Introduction: Though leave against medical advice (LAMA) is a common healthcare problem in low-income countries, there is paucity of studies exploring this aspect of care from Nepal. Our study aims to find out the prevalence of LAMA, its reasons and any differences that exist among patients in neurosurgery versus other specialties. Methods: A prospective, cross-sectional study was carried out among patients discharged against medical advice from September 2020 through February 2021 at Gandaki Medical College, Pokhara. Results: A total of 150 patients were included, 29.3% (n=44) from neurosurgery and 70.7% (n=106) from other departments. The overall rate of LAMA was 5.68%; 16.73% from neurosurgical service. In the neurosurgical cohort, mean age was 61.41±18.72 years and majority of patients were males (65.9%). Most patients were Hindu by religion (97.7%), illiterate (59.1%), married (93.2%), with history of substance abuse (63.6%), admitted directly to the ICU (88.6%) and lacked insurance (79.5%). Financial insufficiency (40.9%) followed by expected poor prognosis of the disease (25%) were reported as major reasons for LAMA. Statistically significant differences (p<0.05) were observed in neurosurgical patients when compared to patients from other departments in terms of age, gender, educational status, history of substance abuse, place of in-patient admission, treatment modality recommended, status of mechanical ventilation and insurance status. In-patient admission to the ICU and proposal of surgical intervention were predictive of LAMA among neurosurgical patients. Conclusions: The rate of LAMA was high in neurosurgery. Educating general public about neurosurgical care and widespread implementation of health insurance seem important policy-implications.
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WENZEL, SUZANNE L., BARBARA D. LEAKE, RONALD M. ANDERSEN, and LILLIAN GELBERG. "Utilization of Birth Control Services among Homeless Women." American Behavioral Scientist 45, no. 1 (September 2001): 14–34. http://dx.doi.org/10.1177/00027640121956999.

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Although homeless women appear to be at notable risk of unintended pregnancy, insufficient attention has been paid to understanding their access to birth control services and the characteristics of homeless women who want birth control services. To address these research gaps, the authors analyzed data from a probability sample of 974 homeless women who were interviewed in shelters and meal programs in Los Angeles County. Multivariate logistic regression analysis revealed that among those women who wanted birth control services during the past year, using these services was associated with fewer perceived barriers to health care, having a regular source of care, consistent use of contraception, and lower odds of alcohol dependence. Availability and cost barriers to birth control services must be reduced, and effective service linkages should be developed among providers of birth control services, substance abuse treatment, and primary care.
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Sung, Chih-Wei, Chi-Hsin Chen, Cheng-Yi Fan, Jia-How Chang, Chia Chun Hung, Chia-Ming Fu, Li Ping Wong, Edward Pei-Chuan Huang, and Tony Szu-Hsien Lee. "Mental health crisis in healthcare providers in the COVID-19 pandemic: a cross-sectional facility-based survey." BMJ Open 11, no. 7 (July 2021): e052184. http://dx.doi.org/10.1136/bmjopen-2021-052184.

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ObjectivesDuring a pandemic, healthcare providers experience increased mental and physical burden. Burnout can lead to treatment errors, patient mortality, increased suicidal ideation and substance abuse as well as medical malpractice suits among medical staff. This study aimed to investigate the occurrence of burnout, acute stress disorder, anxiety disorder and depressive disorder among healthcare providers at the third month of the COVID-19 pandemic.DesignA cross-sectional facility-based survey.SettingHospitals around the country with different levels of care.ParticipantsA total of 1795 respondents, including 360 men and 1435 women who participated in the survey.Primary outcome measuresBurnout was assessed using the Physician Work Life Study. A score of ≥3 implied burnout.ResultsOf the 1795 respondents, 723 (40.3%) reported burnout, and 669 (37.3%) cared for patients with COVID-19. Anxiety levels were mild in 185 (10.3%) respondents, moderate in 209 (11.6%) and severe in 1401 (78.1%). The mean Center for Epidemiologic Studies Depression Scale-10 score was 9.5±6.3, and 817 (45.5%) respondents were classified as having depression. Factors associated with burnout were working in acute and critical care (ACC) divisions (adjusted OR (aOR)=1.84, 95% CI 1.20 to 3.39, p=0.019), caring for patients with COVID-19 (aOR=3.90, 95% CI 1.14 to 13.37, p=0.031) and having depressive disorder (aOR=9.44, 95% CI 7.44 to 11.97, p<0.001).ConclusionsPhysicians and nurses are vulnerable to burnout during a pandemic, especially those working in ACC divisions. Anxiety disorder, depressive disorder and care of patients with COVID-19 may be factors that influence the occurrence of burnout among healthcare providers.
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Sher, Leo. "Risk and Protective Factors for Suicide in Patients with Alcoholism." Scientific World JOURNAL 6 (2006): 1405–11. http://dx.doi.org/10.1100/tsw.2006.254.

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Alcoholism is associated with a high risk for suicidal behavior. Up to 40% of persons with alcoholism attempt suicide at some time and 7% end their lives by committing suicide. Risk factors include being male, older than 50 years of age, living alone, being unemployed, poor social support, interpersonal losses, continued drinking, consumption of a greater amount of alcohol when drinking, a recent alcohol binge, previous alcohol treatment, a family history of alcoholism, a history of comorbid substance abuse (especially cocaine), a major depressive episode, serious medical illness, suicidal communication, and prior suicidal behavior. Suicidal behavior is especially frequent in patients with comorbid alcoholism and major depression. However, all patients with alcoholism should be evaluated for suicide risk. Understanding of risk and vulnerability to suicidal behavior in alcoholism still outweighs our knowledge of protective factors and resilience. Knowledge of protective factors for suicide may help to prevent and/or predict suicidal behavior. Protective factors for suicide in alcoholism are quite varied and include an individual's biological and behavioral characteristics, as well as attributes of the environment and culture. Protective factors include effective clinical care for psychiatric (including alcoholism and drug abuse) and physical disorders, easy access to a variety of clinical interventions and support for seeking help, restricted access to highly lethal means of suicide, strong connections to family and community support, skills in problem solving and conflict resolution, cultural and religious beliefs that discourage suicide and support self-preservation. Future studies are necessary to determine which interventions may reduce suicidal behavior in alcoholism.
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Fiori Nastro, Federico, Martina Pelle, Flavia Di Michele, Alessandra Talamo, Cinzia Niolu, and Alberto Siracusano. "T118. A CROSS-SECTIONAL STUDY ON OUTCOMES OF INDIVIDUALS WITH FIRST HOSPITALIZATION AND PSYCHOSIS SPECTRUM DISORDER DIAGNOSIS." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S275—S276. http://dx.doi.org/10.1093/schbul/sbaa029.678.

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Abstract Background Acute psychosis is one of the most frequent causes of hospital admission. One of the major challenges is how to manage with negative symptoms. Clinical efficacy of treatment of patients at their first hospitalization has been evaluated in several studies. We carried out a cross sectional study focusing on the different outcomes considering the clinical relevance of positive and negative symptoms. Methods We analyzed all the admissions and discharges of patients at their first psychiatric hospitalization after psychosis onset (diagnosed with ICD-9 criteria) in our inpatient psychiatric acute unit of Policlinico Tor Vergata, (located in a suburb of Rome) considering the period of time between January 2017 and September 2019. We characterized all patients according to age, ethnicity, socioeconomic status, substance use/abuse, violent behaviours, voluntary or compulsory treatment, length of hospitalization and use of long acting injection (LAI). We included 73 patients (out of 626 admissions, 12%) with a diagnosis of spectrum psychosis disorder at first hospitalization. We used items 10–11 and 16–17 from the Brief Psychiatric Rating Scale (BPRS) to obtain two groups of patients with different clinical features. Based on the score of these items, patients were divided into two groups: group One characterized by prevalent positive symptomatology and group Two characterized by negative symptoms. Then, we compared clinical outcomes through BPRS, days of Hospital stay and Clinical Global Impression at the end of the hospitalization. Results In our study we found out that patients with BPRS prevalent negative symptoms had longer hospital stays (mean 17.29 days); patients with BPRS positive prevalent symptoms had a mean stay of 15 days. Group Two patients used LAI treatment less frequently (37% of the times) compared to group One, which was treated with LAI 63% of the cases. At discharge, group Two had still higher scores in the Global Improvement Scale compared to group One. Discussion Our study confirms that the use of antipsychotic therapy does not improve negative symptoms. Moreover, psychosis characterized by negative symptoms has a worse outcomes. Furthermore, considering their first hospitalization, it is interesting to note that our participants’ mean age was 37.98 years old, much higher than the one reported in literature. Since our Hospital is located in a very peripheral area of Rome, where social disadvantage represents a critical issue, we hypothesized different reasons to explain this data such as lower level of education, marginalization and socioeconomic adversity that might increase difficulties to access to health care services. In conclusion, further studies are needed to find more useful and alternative treatments and to deepen relationship between sociodemographic context and the time of their first psychiatric assessment.
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Hopwood, C. J., M. B. Donnellan, and M. C. Zanarini. "Temperamental and acute symptoms of borderline personality disorder: associations with normal personality traits and dynamic relations over time." Psychological Medicine 40, no. 11 (December 17, 2009): 1871–78. http://dx.doi.org/10.1017/s0033291709992108.

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BackgroundRecent research suggests the utility of distinguishing temperamental and acute symptoms of borderline personality disorder (BPD). Temperamental symptoms, such as chronic anger and odd thinking, remit relatively slowly and have been hypothesized to reflect a hyperbolic predisposition to emotional pain and negativistic cognitions, whereas acute symptoms, such as substance abuse and chaotic relationships, remit relatively quickly and have been hypothesized to represent the consequences of maladaptations to triggering environmental events.MethodThe relationships of temperamental and acute BPD symptoms with normal personality traits and stability and dynamic associations over time across these symptom sets were tested in a 10-year longitudinal study of 362 patients with personality disorders.ResultsTemperamental symptoms were associated with high neuroticism, whereas acute symptoms were associated with low agreeableness. These symptoms had similar rank-order stabilities and relative changes in symptom sets were reciprocally linked in a cross-lagged path model suggesting dynamic associations between temperamental and acute symptoms over time.ConclusionsThe distinction between temperamental and acute BPD symptoms is supported by differential relations of these symptom sets to normal personality traits. Moreover, these symptoms appear to be linked in a mutually reinforcing dynamic over time. This distinction should be kept in mind in future studies of the aetiology of BPD and in diagnostic and treatment considerations.
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Aziz, Ilhamuddin, Yuyun Widaningsih, Rosdiana Natzir, and A. Jayalangkara Tanra. "ELEVATED UNCONJUGATED BILIRUBIN IN SCHIZOPHRENIC PATIENTS." Nusantara Medical Science Journal 3, no. 1 (December 31, 2018): 20. http://dx.doi.org/10.20956/nmsj.v3i1.5780.

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Strategies for schizophrenic treatment still have been developed in order to increase their effectively, based on latest findings in the etio-pathology. Coincidence of hyperbilirubinemia, especially related to Gilbert’s Syndrome (GS), and schizophrenia/other psychiatric disorders, was reported in several studies although the pattern of this alteration is still controversial. Bilirubin could induce microglia to release pro-inflammatory cytokine that cause neuroinflammation, one of hypothetic etio-pathogenesis has been the most extensively studied recently. However, no data have been presented about this phenomenon in Indonesia. Therefore, this study aims to investigate plasma bilirubin concentration in psychotic spectrum.This study is cross sectional design that we examined both the total bilirubin and direct bilirubin of every psychotic patient admitted for the first time to Rumah Sakit Khusus Daerah (RSKD) Provinsi Sulawesi Selatan over a period of July—December 2012, by using health people as control. Diagnostic determination was set based on International Classification of Diseases (ICD) 10. Patients suffering from any disease such as anemia (decreased hemoglobin), liver diseases (elevated liver enzymes), or substance abuse were excluded. From 73 samples, we found that plasma UCB level was significantly elevated, higher in psychotic patients, especially schizophrenic group, than in the control. Total bilirubin rate was slightly increased in schizophrenic group compare to the others and two samples in this group showed hyperbilirubinemia. Further investigations are needed to ensure that whether the elevated UCB was related to GS and whether this condition has inflammatory effect.
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Fatemi, Saghar, Robabeh Soleimani, Mohammad Ali Yazdanipour, Mohammad Hassan Novin, and Elahe Abdollahi. "Psychometric Properties of 20-Item and 10-Item Persian Versions of Drug Abuse Screening Test." Journal of Holistic Nursing And Midwifery 32, no. 3 (July 1, 2022): 234–41. http://dx.doi.org/10.32598/jhnm.32.3.2366.

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Introduction: Substance use disorder is one of the most critical social problems in Iran. For this disorder, weneed a proper assessment tool based on our indigenous culture. Objective: This study assesses the factor structure and psychometric properties of 10-item and 20-item Persian versions of Drug Abuse Screening Tests (DAST-10 and DAST-20). Materials and Methods: In this cross-sectional study, we randomly selected 200 participants referred to addiction treatment centers in Rasht City, Iran. After translation to Persian and back-translation to English, the face and content validity of DAST-10 and DAST-20 Persian versions were evaluated using the opinions of a panel of expertsand calculatingthe content validity ratio and content validity index. Then, the construct validity was evaluated by Confirmatory Factor Analysis(CFA), the Cronbach α coefficient was used for assessing internal consistency, and the Intraclass Correlation Coefficient (ICC) was used for assessing test-retest reliability. Results: The Mean±SD age of participants was 39.02±11.67 years. The majority (50%) were in the age range of 30-50 years. Based on the CFA fit indices, the two instruments had a good fit to the data, confirming the theoretical model Root Mean Square Error of Approximation (RMSEA) (RMSEA for DAST-20=0.080; RMSEA for DAST-10=0.055). The Cronbach α values ​​of DAST-20 and DAST-10 were 0.772 and 0.749, respectively, indicating their good and acceptable internal consistency. Their test-retest reliability was reported at 0.997 and 0.995 based on the results of ICC, respectively. There was a strong and significant positive correlation between the scores of Persian DAST-20 and DAST-10 (r=0.851, P=0.001). Conclusion: The DAST-20 and DAST-10 Persian versions which after correcting the model using confirmatory factor analysis, they were studies in DAST-8 and DAST-16 have good validity and reliability and can be used for screening the possible involvement of drugs in Iranian samples.
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Guyonnet, Emma, Katherine E. Stewart, and Jane A. Davis. "Revealing the Meaning of Cannabis Use as an Occupation: A Scoping Review." Substance Abuse: Research and Treatment 17 (January 2023): 117822182211501. http://dx.doi.org/10.1177/11782218221150113.

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Background: Occupational science and occupational therapy typically perceive occupations as promoting health and well-being. However, this perspective overlooks the many occupations that are viewed as illegal, unhealthy, or risky, such as drug use. Due to its negative association with health, drug use is perceived as not holding significance or meaning in people’s lives. Objective: This study explores how individuals perceive and describe the meaning of their cannabis use in the context of their lives, from an occupational perspective. Methods: A scoping review was conducted using Levac et al.’ modifications to Arksey and O’Malley’s framework. To examine the peer-reviewed literature, 7 databases were searched using terms related to cannabis and meaning. Descriptive statistics were used to describe the selected studies, and reflexive thematic analysis identified cross-study themes. Results: Fourteen studies were selected. Most studies have been published since 2008, with 5 published in the last 2 years. Four themes were identified across the studies: (a) preserving life; (b) navigating the routines of everyday life; (c) understanding the self, identity, and belonging; and (d) expanding the view of the world. Conclusions: Cannabis use was revealed in this study as a support for navigating occupational routines and enhancing occupational repertoires and engagement, feelings of belonging, and collective user identities. As such, substance abuse treatment practices, including those provided by occupational therapists, should recognize the potential significance of cannabis use within people’s lives. Using a harm reduction approach, occupational therapists can acknowledge the ways in which clients use cannabis to manage their daily routines, while also focusing on supporting clients to reduce the ill-effects of cannabis. As individuals become more engaged in occupations that are significant in their lives, their need for and meaning of cannabis use may change leading to a possible reduction in its use and a shift in their identity construction.
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Verderber, Stephen, Jake Pauls Wolf, and Erik Skouris. "Indigenous Ecohumanist Architecture for Health in Canada’s Far North." HERD: Health Environments Research & Design Journal 13, no. 4 (June 22, 2020): 210–24. http://dx.doi.org/10.1177/1937586720933176.

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Background: Circumpolar nations are experiencing unprecedented environmental and public health policy challenges due to global climate change, exploitation of nonrenewable natural resources, the endangerment of myriad wildlife species, and growing sovereignty disputes. In a call to action, the Arctic states’ health ministers recently signed a declaration identifying shared priorities for mutual international cooperation. Among agreed-upon collaborations, an enhancement of intercultural understanding and promotion of culturally appropriate healthcare delivery systems is to be of high priority going forward. Purpose and Aim: In far north Canada, health policies perpetuated for generations upon indigenous communities have, traditionally, often had adverse consequences for the medically underserved inhabitants of these communities. This discussion addresses the cultural disconnect between the colonial era and current indigenous, decolonialist health and healing design strategies. Method and Result: In response, two architectural design case studies are presented that synthesize ecological site planning precepts with salutogenic architectural design attributes—a behavioral health and substance abuse residential treatment center and three elderhousing prototypes for construction in Canada’s Northwest Territories. Conclusion: This conceptual synthesis is practicable, transferable, and adaptable to varied, extreme climatic conditions, as reflective of best practices in the delivery of healthcare facilities that express a synthesis of ecohumanist and salutogenic values and methodologies. The discussion concludes with a call for empathic, evidence-based collaboration and research that further examines the blending together of prefabricated off-site construction with on-site construction approaches.
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Sau, Manabendra, Amal Kumar Sinha Roy, Pausali Das, and Jitendra Kumar Singh. "Pattern of substance abuse: a community based study in West Bengal." International Journal Of Community Medicine And Public Health 5, no. 8 (July 23, 2018): 3394. http://dx.doi.org/10.18203/2394-6040.ijcmph20183068.

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Background: Drug addiction produces serious pervasive and expensive social problems. Regardless of whether substance abuse is a sin, a crime, a bad habit or an illness society has a right to expect that an effective approach to drug abuse problem will reduce drug related crime unemployment, family dysfunction and disproportionate use of medical care. Science has made great progress over the past several years, but it is still not possible to account fully the physiological and psychological process that transform controlled voluntary use of drugs into uncontrolled is voluntary dependence on those substances, and these is still no cine. The objective of the study was to find out pattern of different types of substance abuse in a community in West Bengal.Methods: An observational cross-sectional community based study during April 2017-September 2017 in a community of West Bengal among 142 addicted persons.Results: In the studied 142 cases, Brown sugar (an adulterated form of Heroin) was primary drug of abuse in urban area contrary to alcohol in rural area. Commonest age of initiation was between 15-20 years (57.75%). Polydrug abusers (59.1%) were common.Conclusions: Our study revealed that in spite of having strict legislation for prohibition of substance abuse, people are still addicted with alcohol, cannabis, drugs etc. Substance use is prevalent in the studied area, with a higher prevalence in males. Substance users rarely seek treatment for substance use. This needs continuous awareness and community-level services for the treatment of substance use disorders.
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Odlum, Michelle, and Sunmoo Yoon. "Understanding Comorbidities and Their Contribution to Predictors of Medical Resource Utilization for an Age- and Sex-Matched Patient Population Living With HIV: Cross-Sectional Study." JMIR Aging 2, no. 2 (September 11, 2019): e13865. http://dx.doi.org/10.2196/13865.

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Background More than 60% of people aging with HIV are observed to have multiple comorbidities, which are attributed to a variety of factors (eg, biological and environmental), with sex differences observed. However, understanding these differences and their contribution to medical resource utilization remains challenging as studies conducted exclusively and predominantly among males do not translate well to females, resulting in inconsistent findings across study cohorts and limiting our knowledge of sex-specific comorbidities. Objective The objective of the study was to provide further insight into aging-related comorbidities, their associated sex-based differences, and their contribution to medical resource utilization, through the analysis of HIV patient data matched by sex. Methods International Classification of Disease 9/10 diagnostic codes that comprise the electronic health records of males (N=229) and females (N=229) were categorized by individual characteristics, chronic and mental health conditions, treatment, high-risk behaviors, and infections and the codes were used as predictors of medical resource utilization represented by Charlson comorbidity scores. Results Significant contributors to high Charlson scores in males were age (beta=2.37; 95% CI 1.45-3.29), longer hospital stay (beta=.046; 95% CI 0.009-0.083), malnutrition (beta=2.96; 95% CI 1.72-4.20), kidney failure (beta=2.23; 95% CI 0.934-3.52), chemotherapy (beta=3.58; 95% CI 2.16-5.002), history of tobacco use (beta=1.40; 95% CI 0.200-2.61), and hepatitis C (beta=1.49; 95% CI 0.181-2.79). Significant contributors to high Charlson scores in females were age (beta=1.37; 95% CI 0.361-2.38), longer hospital stay (beta=.042; 95% CI 0.005-0.078), heart failure (beta=2.41; 95% CI 0.833-3.98), chemotherapy (beta=3.48; 95% CI 1.626-5.33), and substance abuse beta=1.94; 95% CI 0.180, 3.702). Conclusions Our findings identified sex-based differences in medical resource utilization. These include kidney failure for men and heart failure for women. Increased prevalence of comorbidities in people living long with HIV has the potential to overburden global health systems. The development of narrower HIV phenotypes and aging-related comorbidity phenotypes with greater clinical validity will support intervention efficacy.
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Haryadi, Rudi, Eka Sri Handayani, and Sri Ayatina Hayati. "Psychological well-being of ex-drug addicted counselee in post-rehabilitation education." Jurnal Psikologi Pendidikan dan Konseling: Jurnal Kajian Psikologi Pendidikan dan Bimbingan Konseling 6, no. 1 (June 30, 2020): 1. http://dx.doi.org/10.26858/jppk.v6i1.12422.

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This study aims to analyze the level of psychological well-being of ex-drug addicted counselee in post-rehabilitation education. The study was conducted in 2 communities of post-rehabilitation education providers in Semarang city. The level of psychological well-being of 40 respondents was measured by filling in the 18-item psychological well-being scale developed by Ryff (r = 0.83; v = 0.97). Measurement includes indicators: (1) self-acceptance; (2) positive relationships with others; (3) autonomy; (4) environmental mastery; (5) purpose in life; and (6) personal growth. Hypothesis test results indicate that the level of psychological well-being of ex-drug addicted counselee in post-rehabilitation education is significantly greater or equal to 80 (t = 49,140; sig = 0,000). Based on the results of this study, it is recommended to further researchers to further explore certain differences in the level of psychological well-being of the counselee by the factors of age, demographics, educational background, and length of abstinence. In addition, further studies with a larger number of samples and questionnaire items are needed so that study results can be generalized to a wider population.Ardiantina, D. (2016). Studi Kasus Kehidupan Remaja Mantan Pecandu Narkoba. Jurnal Bimbingan dan Konseling, 5(1), 1-12.Astuti, R., & Ismandari, F. (2014). Gambaran Umum Penyalahgunaan Narkoba di Indonesia. Buletin Jendela Data dan Informasi Kesehatan. I, pp. 1-52. Jakarta: Kementrian Kesehatan RI.Aztri, S., & Milla, M. N. (2013). Rasa Berharga Dan Pelajaran Hidup Mencegah Kekambuhan Kembali Pada Pecandu Narkoba Studi Kualitatif Fenomenologis. Jurnal Psikologi, 9(1), 48-63.Bhandari, S., Dahal, M., & Neupane, G. (2015). Factors Associated With Drug Abuse Relapse: A Study On The Clients Of Rehabilitation Centers. Al-Ameen Journal of Medicine and Science, 8(4), 293-298.BNN. (2015). Laporan Akhir Survei Nasional Perkembangan Penyalahgunaan Narkoba Tahun Anggaran 2014. Jakarta: Badan Narkotika Nasional Indonesia.Buchanan, T. (2011). Attention Defi cit/Hyperactivity Disorder and Well-being: Is Social Impairment an Issue for College Students with ADHD? Journal of Postsecondary Education and Disability, 24(3), 193-210.Bukoye, R. O. (2017). Academic Stress and Drug Abuse as Factors Inhibiting Psychological Well-Being Among Undergraduates: It’s Counselling Implications. European Scientific Journal, 13(8), 60-74.Chong, J., & Lopez, D. (2008). Predictors of Relapse for American Indian Women After Substance Abuse Treatment. Journal of The National Center, 14(3), 24-47.Dogaheh, E. R., Jafari, F., Sadeghpour, A., Mirzaei, S., Maddahi, M. E., Hosseinkhanzadeh, A. A., & Arya, A. R. (2013). Psychological Well-Being and Quality of Sleep in Addicts under Methadone Maintenance Treatment. Research Papers, 1(2), 71-75.Fard, A. E., Rajabi, H., Delgoshad, A., Rad, S. A., & Akbari, S. (2014). The Possible Relationship between University Students' Personality Traits, Psychological Well-being and Addiction Potential. International Journal of Social Science Studies, 2(2), 120-125.Garcia, D., Nima, A. A., & Kjell, O. N. (2014). The Affective Profiles, Psychological Well-Being, and Harmony: Environmental Mastery and Self-Acceptance Predict the Sense of a Harmonious Life. PeerJ, 1-21.Green, M., & Elliott, M. (2010). Religion, Health, and Psychological Well-Being. Journal of Religion and Health, 49, 149-163.Greenfield, E., Vaillant, G., & Marks, N. (2009). Doformal religious participation and spiritual perceptions have independent linkages with diverse dimensions of psychological well-being? Journal of Health and Social Behavior, 50, 196–212.Haryadi, R. (2018). Prospek Konseling Komunitas bagi Individu Eks-Pecandu Narkoba (Studi Pada Lembaga Pasca-Rehabilitasi Narkoba Di Kota Semarang). Konseli (Jurnal Bimbingan dan Konseling), 5(1), 73 - 84.Ibrahim, F., & Kumar, N. (2009). Factors Effecting Drug Relapse in Malaysia: An Empirical Evidence. Asian Social Science, 5(12), 37-44.Lindfors, P., Berntsson, L., & Lundberg, U. (2007). Total workload as related to psychological well-being and symptoms in full-time employed female and male white-collar workers. International Journal of Behavior and Medicine, 13, 131-137.Martin, R. A., MacKinnon, S., Johnson, J., & Rohsenow, D. J. (2011). Purpose in life predicts treatment outcome among adult cocaine abusers in treatment. Journal of Substance Abuse Treatment, 40, 183–188.Ryff, C. D. (2014). Psychological Well-Being Revisited: Advanced in the Science and Practice of Eudaimonia. Psychoterapy and Psychosmoatics, 83, 10-28.Ryff, C. D., Love, G. D., Miyamoto, Y., Markus, H. R., Curhan, K. B., Kitayama, S., . . . Karasawa, M. (2014). Culture and the promotion of well-being in East and West: Understanding varieties of attunement to the surrounding context. In G. A. Fava, & C. Ruini, Increasing psychological well-being in clinical and education settings: Interventions and cultural contexts (Vol. 8th, pp. 1-19). New York: Springer.Schaefer, S. M., Boylan, J. M., Reekum, C. M., Lapate, R. C., Norris, C. J., Ryff, C. D., & Davidson, R. J. (2013). Purpose in Life Predicts Better Emotional Recovery for Negative Stimuli. Plos ONE, 8(11), 1-9.Schwartz, R. P., Kelly, S. M., O’Grady, K. E., Mitchell, S. G., Peterson, J. A., Reisinger, H. S., . . . Brown, B. S. (2008). Attitudes toward buprenorphine and methadone among opioid-dependent individuals. American Journal of Addicton, 17, 396–401.Seligman, M. E. (2010). Flourish: Positive Psychology and Positive Intervention. Michigan: University of Michigan.Sharma, A. K., Upadhyaya, S. K., Bansal, P., Nijhawan, M., & Sharma, D. (2012). A Study of Factors Affecting Relapse in Substance Abuse. Indian Journal of Science and Technology, 2(1), 31-35.Siddiqui, S. (2015). Impact of self-efficacy on psychological well-being among undergraduate students. The International Journal of Indian Psychology, 2(3), 5-17.Strauser, D., Lustig, D., & Çıftçı, A. (2008). Psychological well-being: its relation to work personality, vocational identity, and career thoughts. Journal of Psychology, 142, 21–35.Vasquez, C., & Castilla, C. (2007). Emociones Positivas y Crecimiento Postraumatico en el Cancer de Mama. Psicooncologia, 4, 385-404.
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Sijuwade, Philip O. "CROSS-CULTURAL PERSPECTIVES ON ELDER ABUSE AS A FAMILY DILEMMA." Social Behavior and Personality: an international journal 23, no. 3 (January 1, 1995): 247–51. http://dx.doi.org/10.2224/sbp.1995.23.3.247.

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Comparative studies of cases by type of elder abuse disclosed distinct profiles of abuse, neglect, and financial exploitation. Physical and psychological abuse were more closely associated with the problems of perpetrators than the victim. Victim-perpetrator dependency, perpetration psychopathology, and care giver stress, emerge from the comparative studies as major risk factors for elder mistreatment with substance abuse and social isolation as serious contributing elements. Elder abuse challenges belief in the sanctity of the home and the inherent goodness of man. Also, it raises basic ethical and legal dilemmas regarding the elder's right to self determination and society's desire to intervene. To arrive at a better understanding of this difficult problem, the experience of all countries will be needed.
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43

Brown, Lawrence S., Steven Kritz, R. Jeffrey Goldsmith, Edmund J. Bini, Jim Robinson, Donald Alderson, and John Rotrosen. "Health Services for HIV/AIDS, HCV, and Sexually Transmitted Infections in Substance Abuse Treatment Programs." Public Health Reports 122, no. 4 (July 2007): 441–51. http://dx.doi.org/10.1177/003335490712200404.

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The National Drug Abuse Treatment Clinical Trials Network conducted this study to determine the availability of and factors associated with infection-related health services in substance abuse treatment settings. In a cross-sectional descriptive design, state policies, reimbursement for providers, state level of priority, and treatment program characteristics were studied via written surveys of administrators of substance abuse treatment programs and of state health and substance abuse departments. Data from health departments and substance abuse agencies of 48 states and from 269 substance abuse treatment programs revealed that human immunodeficiency virus/acquired immunodeficiency syndrome-related services are more frequent than hepatitis C virus or sexually transmitted infection-related services, and that nonmedical services are more frequent than medical services. While the availability of infection-related health services is associated with medical staffing patterns, addiction pharmacotherapy services, and state priorities, reimbursement was the most significant determining factor. These findings suggest that greater funding of these health services in substance abuse treatment settings, facilitated by supportive state policies, represents an effective response to the excess morbidity and mortality of these substance use-related infections.
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44

Teaster, Pamela B. Teaster, and Georgia Anetzberger. "THE FACES OF ELDER ABUSE: A CROSS-CULTURAL PERSPECTIVE." Innovation in Aging 6, Supplement_1 (November 1, 2022): 282. http://dx.doi.org/10.1093/geroni/igac059.1120.

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Abstract This presentation gives a real world and compelling picture of the abuse of older adults, with authors representing three different World Health Regions (i.e., Regional Office for Africa, Regional Office for Southeast Asia, and the Regional Office for the Western Pacific) each locating the problem within an area’s historic and present societal treatment of older persons. An actual and emblematic case study of the abuse of an older adult will frame each presentation. Presenters will synthesize empirical data and research on the problem, explaining its usefulness and limitations as well as guiding frameworks utilized to address the problem, highlighting efforts of leading figures in each area or region who are addressing the problem and explaining existing policies and future initiatives to address the abuse of older adults. Dr. Eniola Cadmus will present perspectives on elder abuse in Nigeria. Drs. Noriko Tskudada and Asako Katsumata and will present perspectives from Japan. Drs. Farida Ejaz and Mala Shankardass will present perspectives from India. Dr. Georgia Anezberger will tie together the differences and commonalities within each region drawing upon a holistic and person-centered picture of the issue and problem of elder abuse.
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Taghva, Maryam, Ramin Shiraly, and Ebrahim Moghimi Sarani. "Exploring the Demographic Factors and Facilitators to Addiction Abstinence." Galen Medical Journal 7 (December 10, 2018): e1074. http://dx.doi.org/10.31661/gmj.v7i0.1074.

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Background: Accumulating evidence indicates a remarkable increase in substance addiction. Substance abuse and addiction impose severe social, political, economic, cultural and health-related damages on societies. Little is known, however, about demographic factors and facilitators to addiction abstinence. The purpose of the current study was to explore the factors associated with opioid avoidance.Materials and Methods: This cross-sectional study was performed to record socio-de­mographic data and facilitating factors to abstinence in 600 interviews, according to data collecting forms, with patients who had drug abuse disorders at Shiraz city during 2016. Correlation test, T-test, and ANOVA were employed for data analysis. P<0.05 was considered as the significance level. Result: There was a significant difference between mean abstinence time and demographic factors such as age, sex, occupation and marital status. Also, 53% of people reported that they had the longest abstinence time using the narcotics anonymous (NA) method. TO 33% of patients, the most important facilitating factor in abstinence according to the patient's opinion was family support.Conclusion: Individual, social, psychosocial and medical variables affect the abstinence duration of substance abuse. Identifying the factors associated with longer abstinence can be helpful in designing prevention and treatment programs for variables that affect the recurrence.[GMJ.2018;7:e1074]
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Macam, Samantha Reyes, Wendy Mack, Lawrence Palinkas, Michele Kipke, and Joyce Rivera Javier. "Evaluating an Evidence-Based Parenting Intervention Among Filipino Parents: Protocol for a Pilot Randomized Controlled Trial." JMIR Research Protocols 11, no. 2 (February 17, 2022): e21867. http://dx.doi.org/10.2196/21867.

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Background Filipino Americans underuse mental health and preventive care services even though studies have indicated that Filipino youth experience high rates of suicidal ideation, substance abuse, and teen pregnancies, whereas adults experience immigration stress, discrimination, and depression. Evidence-based parenting interventions provided in early childhood have proven to be effective in preventing the onset and escalation of child mental health disorders. In a pilot randomized controlled trial, we found that participation in the Incredible Years Basic Parent Training Program (IY) improved parenting stress and positive parenting practices and decreased child internalizing and externalizing symptoms among Filipino families. A fully powered trial is needed to determine the efficacy of IY as a prevention program among Filipino families. Objective The aims of this study are to describe the design and rationale of a randomized controlled trial evaluating the effects of the web-based IY program among parents recruited from multiple community-based settings and its impact on parenting practices, parenting stress, and child problem behavior among Filipino Americans and describe the impact of COVID-19 on our study protocols. Methods This study uses a randomized controlled 2-arm individually randomized group treatment pretest–posttest design for 180 parent–child dyads. Individuals are eligible if they are ≥18 years, live in California, and have at least one Filipino child aged 8-12 years. Consenting participants are randomly allocated to receive either the 12-week IY parenting intervention (intervention arm) or American Academy of Pediatrics’ Bright Future handouts and placed on a waitlist to receive IY posttrial (waitlist control arm). Primary outcomes include the Parent Practices Interview and the Parenting Stress Index. Secondary outcomes will be measured using the Child Behavior Checklist (completed by parent) and will include child internalizing and externalizing behaviors and total problems. Data are collected at baseline and 3- and 6-month follow-ups. Results Changes made to the protocol owing to COVID-19 include administration of surveys remotely and implementation of the intervention on the web. The pandemic has provided an opportunity to evaluate the effectiveness of a web-based version of IY that may improve access and increase use of the intervention. Recruitment and data collection procedures are still ongoing and are expected to be completed by December 2022. Conclusions Our research will determine whether IY promotes positive parenting practices and prevents child internalizing and externalizing behaviors in healthy but high-risk populations such as Filipino families. It will also uplift cultural narratives and add to the evidence base for web-based parenting programs and their implementation in real-world settings. If found efficacious, IY has the potential to prevent behavioral health disparities in this understudied and high-risk Filipino population and can be scaled, adapted, and implemented in other at-risk racial and ethnic minority communities. Trial Registration ClinicalTrials.gov NCT04031170; https://clinicaltrials.gov/ct2/show/NCT04031170 International Registered Report Identifier (IRRID) DERR1-10.2196/21867
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Sellami, R., N. Messedi, I. Feki, D. Trigui, A. Zahaf, and J. Masmoudi. "Epidemiological profile of drug users in Tunisia." European Psychiatry 33, S1 (March 2016): S308. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1055.

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IntroductionChanging cultural values and increasing economic stress are leading to initiation into substance use. Despite religious and legal constraints on Muslims against the consumption of drugs, drug addiction is a widespread problem and is destroying the lives of many individuals and families, in Tunisia.ObjectivesTo examine the socio-demographic characteristics of Tunisian addicts and to identify the drugs commonly used.MethodsThis was a cross-sectional study, which included 200 patients at the addiction treatment center “Aide et Ecoute” in Sfax (Tunisia). The survey was conducted during the month of January to September 2014.ResultsOnly males were found to get treatment in the addiction center for various addictions. The mean age was 33.32 years and the mean age for starting substance use was 17.30 years. More than half (65.9%) were not married and 59.5% had involvement with criminal justice. Substance dependence was commonly seen in poor and middle socioeconomic class. The most common substance used was buprenorphine (34.8%). There was a significant relation between buprenorphine consumption and immigration (P= 0.013). Peer pressure was one of the most important factors for trial of substance in our study.ConclusionAs the mean age of initiation of substance abuse was early twenties, in liaison with schools and colleges, some recreational activities can be generated to prevent diversion of youth towards the devil of drug abuse.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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48

Trotter, Robert, Monica Lininger, Ricky Camplain, Viacheslav Fofanov, Carolyn Camplain, and Julie Baldwin. "A Survey of Health Disparities, Social Determinants of Health, and Converging Morbidities in a County Jail: A Cultural-Ecological Assessment of Health Conditions in Jail Populations." International Journal of Environmental Research and Public Health 15, no. 11 (November 8, 2018): 2500. http://dx.doi.org/10.3390/ijerph15112500.

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The environmental health status of jail populations in the United States constitutes a significant public health threat for prisoners and the general population. The ecology of jails creates a dynamic condition in relation to general population health due to the concentrated potential exposure to infectious diseases, difficult access to treatment for chronic health conditions, interruption in continuity of care for serious behavioral health conditions, as well as on-going issues for the prevention and treatment of substance abuse disorders. This paper reports on elements of a cross-sectional survey embedded in a parent project, “Health Disparities in Jail Populations.” The overall project includes a comprehensive secondary data analysis of the health status of county jail populations, along with primary data collection that includes a cross-sectional health and health care services survey of incarcerated individuals, coupled with collection of biological samples to investigate infectious disease characteristics of a county jail population. This paper reports on the primary results of the survey data collection that indicate that this is a population with complex and interacting co-morbidities, as well as significant health disparities compared to the general population.
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49

Landa, L., K. Šlais, and A. Šulcová. "Impact of Cannabinoid Receptor Ligands on Sensitisation to Methamphetamine Effects on Rat Locomotor Behaviour." Acta Veterinaria Brno 77, no. 2 (2008): 183–91. http://dx.doi.org/10.2754/avb200877020183.

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The repeated administration of various drugs of abuse may lead to a gradually increased behavioural response to these substances, particularly an increase in locomotion and stereotypies may occur. This phenomenon is well known and described as behavioural sensitisation. An increased response to the drug tested, elicited by previous repeated administration of another drug is recognised as cross-sensitisation. Based on our earlier experiences with studies on mice, which confirmed sensitisation to methamphetamine and described cross-sensitisation to methamphetamine after pre-treatment with cannabinoid CB1 receptor agonist, we focused the present study on the use of another typical laboratory animal - the rat. A biological validity of the sensitisation phenomenon was expected to be enhanced if the results of both mouse and rat studies were conformable. Similar investigation in rats brought very similar results to those described earlier in mice. However, at least some interspecies differences were noted in the rat susceptibility to the development of sensitisation to methamphetamine effects. Comparing to mice, it was more demanding to titrate a dose of methamphetamine producing behavioural sensitisation. Furthermore, we were not able to provoke cross-sensitisation by repeated administration of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate the suppression of cross-sensitisation in rats that were repeatedly given combined pre-treatment with cannabinoid CB1 receptor antagonist AM 251 and methamphetamine. Finally, unlike mice, an alternative behavioural change was registered after repeated methamphetamine treatment instead: the occurrence of stereotypic behaviour (nose rubbing).
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50

Abderemane, Aboubacar, Taher Moussa Ahmadou, Siham Belbachir, Khalid Barkat, and Ahmed Omar Touhami Ahami. "STUDY OF THE IMPACT OF CANNABIS USE ON PERCEPTUAL AND MEMORY PROCESSES AS WELL AS ON POSITIVE AND NEGATIVE SYMPTOMS IN PATIENTS WITH SCHIZOPHRENIA." Acta Neuropsychologica 20, no. 3 (August 25, 2022): 291–303. http://dx.doi.org/10.5604/01.3001.0015.9832.

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Cannabis, as the most widely used illicit substance in the world, also remains among the most frequently used psychoactive substances by patients with schizophrenia. It is well known that cannabis use in schizophrenia patients favors relapse, resistance to antipsychotic treatments and therefore more frequent hospitalizations. However, many studies report considerable improvement in cognitive performance in substance users, while others show the opposite. Hence, the aim of our study is to examine the relationship between schizophrenia and cannabis use in clinical and socio-de- mographic aspects. This is a cross-sectional study of patients with schizophrenia hospitalized for relapse at the Ar-Razi psychiatric hospital in Salé, Morocco. A questionnaire was established in order to search for socio- demographic data, evolutionary and prognostic criteria of the disease. Cannabis use was assessed using the Cannabis Abuse Screening Test (CAST), for the severity of schizophrenia symptoms we used the Positive And Negative Syndrome Scale (PANSS) and for perceptual and memory abilities we used the numerical version of the Rey's Complex Figure-A (RCF-A). It was found that in a sample of 115 schizophrenic patients, 47.82% (n=55) were cannabis users. The mean PANSS (negative) and (general psychopathology) scores of non-cannabis users were significantly higher than those of cannabis users with P values of (P<0.001) and (P<0.005) respectively. For the numerical assessment scores of the RCF-A, cannabis users had a significantly higher mean score than non-cannabis users (copy phase (P<0.016) and memory (P<0.001) As one of the leading risk factors for the emergence of schizophre- nia, chronic cannabis use also has a negative influence on the prognosis of patients already suffering from schizophrenia. Nevertheless, the results of our study show that cannabis-using schizophrenic patients had fewer negative symptoms according to the PANSS and an improved cognitive performance compared to non- cannabis-using patients.
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