Academic literature on the topic 'Subgroup rights'

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Journal articles on the topic "Subgroup rights"

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Spitsyna, Hanna, and Alla Hordeyuk. "Features of modern classification of intellectual property items." Naukovyy Visnyk Dnipropetrovs'kogo Derzhavnogo Universytetu Vnutrishnikh Sprav 3, no. 3 (September 30, 2020): 58–64. http://dx.doi.org/10.31733/2078-3566-2020-3-58-64.

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This article determines modern classification of intellectual property objects, which identified in international regulations and presumed by scientists, studding problematic issues in sphere of intellectual property. The defined, which the most common is classification, with distribution criterion of objects in group to the institutions of intellectual property: copyright and related rights; industrial property law. The individual scientists have their own approach regarding inclusion in different classification groups. The offered with given the content of international law and scientific research of scientists, classify of intellectual property objects by several criteria in depending: from the assignment of objects to a specific legal institutions of intellectual property; from the legal nature of objects which without fail subject to patenting or state registration or on them spread of presumption of authorship; from the title of protection, which issued based on patenting result or state registration of specific objects. By these criteria expediently to highlight such groups and subgroups of intellectual property objects: objects of copyright and related rights with separate subgroup copyright objects and subgroup related rights objects; objects of the institution of industrial property law, where to highlight the patent law objects, the objects, where individualize of participants in civil transaction, goods, services and subgroup of unconventional objects. Determined the need in modern realities of virtualization of legal realities to additions to the list intellectual property objects, which is defined in article 420 Civil code of Ukraine, such facilities of domain name and website. The domain name include in subgroups of industrial property law objects, which individualize of participants in civil transaction, goods and services, and website include in group objects of copyright and related rights, guided by the legislator’s position. The legislator secured concept of website in the law of Ukraine «On copyright and related rights».
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Lund, Thomas B., Sigrid Denver, Jonas Nordström, Tove Christensen, and Peter Sandøe. "Moral Convictions and Meat Consumption—A Comparative Study of the Animal Ethics Orientations of Consumers of Pork in Denmark, Germany, and Sweden." Animals 11, no. 2 (January 28, 2021): 329. http://dx.doi.org/10.3390/ani11020329.

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Background: The relationship between animal ethics orientations and consumer demand for meat with high standards of animal welfare, and the way this relationship plays out in different countries, is not well understood. Using pork as a case study, this comparative study aims to identify the animal ethics orientations that drive purchases of welfare meat in Denmark, Germany, and Sweden. Methods: Cross-sectional questionnaire data from representative samples of approximately 1600 consumers in each country were collected. A segmentation of pork consumers (using latent profile analysis) was carried out. Results: In all three countries, two subgroups were concerned about farm animal welfare: the first subgroup was driven by animal rights values; the second subgroup by animal protection values, where the main principle was that “it is all right to use animals as long as they are treated well”. Other consumer groups are less concerned about farm animal welfare and display little or no preference for welfare pork. Conclusions: In all three countries, dual demand for welfare pork exists. The findings of this study can be used, among others, to understand the marketability of enhanced welfare animal products and the potential for market-driven animal welfare improvements.
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Grechanyi, Severin Vyacheslavovich. "Risk of harmful use of a particular type of psychoactive substance in adolescents with conduct disorders." Pediatrician (St. Petersburg) 6, no. 3 (September 15, 2015): 16–23. http://dx.doi.org/10.17816/ped6316-23.

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The purpose of the study was a statistical evaluation of the role of clinical and anamnestic data for the risk of a particular type of substances use with the harmful effects in adolescents with conduct disorders. Were studied 293 adolescents with a diagnosis of “Conduct disorder” and comorbid diagnoses “Harmful substance use” (mean age - 15,3 ± 0,1 years). Patients were divided into 4 groups. 1 subgroup comprised 89 patients with comorbid diagnosis of “Harmful opioid use”. 2 subgroup comprised 95 patients with comorbid diagnosis of “Harmful inhalant use”. 3 subgroup comprised 57 patients with comorbid diagnosis of “Harmful alcohol drinking”. 4 subgroup consisted of 52 patients with comorbid diagnosis of “Harmful stimulant use”. The result was obtained by logistic regression equation to calculate the risk of supplies to the patients particular clinical subgroup on the basis of statistically significant variables (anamnestic data). For the harmful opioid use subgroup is: “Family history of substance abuse on the one line”, “Schooling program for masses”, status “Is not working/not learning”, “Living with a partner”. For the harmful inhalant use subgroup is: status “Is not working/not learning”, “Living in a boarding school”, “Escape from the house (or boarding)/temporary accommodation in a shelter”. For the harmful alcohol drinking subgroup is: “Half family”, “Correctional school program”, “Supporting school program”, status “Student school”, status “Is not working/not learning“ (negative contribution to the result variable prediction), “Living in a boarding school”. For the harmful stimulant use subgroup is: “Useful family history”, ”Orphan or the parent(s) deprived of their rights” (negative contribution to the result variable prediction), status “Is not working/not learning” (negative contribution to the result variable prediction), “Escape from the house (or boarding)/temporary accommodation in a shelter”, “Living with a partner”.
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Cooper-Cabell, Nicky. "Mind the gap: Post earthquake community wellbeing?" Aotearoa New Zealand Social Work 25, no. 2 (May 15, 2016): 27–34. http://dx.doi.org/10.11157/anzswj-vol25iss2id78.

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Following the September 2010 and February 2011 Canterbury earthquakes the Stronger Canterbury Strategic Planning Framework was developed by the National Psychosocial Response Subgroup with support from the Psychosocial Recovery Advisory Group under the auspices of the Ministry of Health in conjunction with the National Health Emergency Plan (Ministry of Health, 2007, p.18). The Framework’s purpose was to provide an overarching context for the Christchurch Psychosocial Response Subgroup as well as applicable Community Wellbeing subgroups to assist in planning the psychosocial recovery in response to the Canterbury earthquakes. Within the document two essential components to the psychosocial recovery for Canterbury are identified: individual recovery and wellbeing, and the building of community resilience while supporting psychosocial wellbeing. Implicit in the document is the notion that provided the right supports are in place, recovery will occur. This article argues the current pervasive neo-liberal perspective has hampered the ability of those supports to be fully realised. To begin, the strategic planning aims of addressing individual psychosocial wellbeing and community resilience will be defined in this review. Secondly, examples illustrating how the pervading neo-liberal perspective has contributed to the failure of the policy to assist community recovery will be discussed. Examples referring to the notions of rights, equality, social justice and the Treaty of Waitangi will be provided. To conclude, the slow pace of the recovery for Cantabrians has had, and continues to have, multiple implications for the social work community. It is over two years on from the first earthquake, and much of the population are still struggling to gain equilibrium. Social workers in Canterbury have been working tirelessly to improve outcomes for clients. It is suggested it is time social work as a national body advocates for the stakeholders to pay more attention to the original intent of the framework.
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Ben-Natan, Smadar. "Self-Proclaimed Human Rights Heroes: The Professional Project of Israeli Military Judges." Law & Social Inquiry 46, no. 3 (February 4, 2021): 755–87. http://dx.doi.org/10.1017/lsi.2020.39.

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This article explores the cooptation of human rights discourse by looking into how Israeli military judges in the Occupied Palestinian Territories use human rights as professional capital. Previous research into human rights arguments legitimizing the Israeli occupation remained confined to a unitary image of the state. Here, I dissect the separate professional project of military judges. Optimizing a self-congratulatory argument, judges portray themselves as human rights heroes of Palestinians. But while independent judicial activism would criticize human rights violations by the state, military judges use human rights as synonymous with legal professionalism, while avoiding criticism and sidestepping human rights’ challenge to state power.Using a multimethod approach including analysis of judicial decisions, academic articles by military judges, and in-depth interviews, I argue that between 2000 and 2010, Israeli military judges were responding to a professional legitimacy crisis by what I call mimetic convergence. Relying on new institutionalism and postcolonial theory, mimetic convergence produces belonging and mobility for a professional subgroup that experiences alienation in the “colony” through convergence with the specific characteristics of the legal community of the “metropole.” Mimicking the state instead of criticizing it permits the two projects— promoting military judges professionally and legitimizing the state’s colonial occupation—to coalesce.
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Onarheim, Kristine Husøy, Andrea Melberg, Benjamin Mason Meier, and Ingrid Miljeteig. "Towards universal health coverage: including undocumented migrants." BMJ Global Health 3, no. 5 (October 2018): e001031. http://dx.doi.org/10.1136/bmjgh-2018-001031.

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As countries throughout the world move towards universal health coverage, the obligation to realise the right to health for undocumented migrants has often been overlooked. With unprecedented millions on the move – including refugees, asylum seekers, internally displaced persons, and returnees – undocumented migrants represent a uniquely vulnerable subgroup, experiencing particular barriers to health related to their background as well as insecure living and working conditions. Their legal status under national law often restricts access to, and affordability of, healthcare services. While striving to ensure health for all, national governments face challenging priority setting dilemmas in deciding: who to include, which services to provide, and how to cover out-of-pocket expenses. Building on comparative experiences in Norway, Thailand and the United States – which reflect varied approaches to achieving universal health coverage – we assess whether these national approaches provide rights-based access to affordable essential healthcare services for undocumented migrants. To meet the shared Sustainable Development Goal on universal health coverage, the right to health must be realised for all persons – including undocumented migrants. To ensure universal health coverage in accordance with the right to health, governments must evaluate laws, regulations, policies and practices to evaluate: whether undocumented migrants are included, to which services they have access, and if these services are affordable. Achieving universal health coverage for everyone will require rights-based support for undocumented migrants.
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Darling, Kate. "Still waiting for the benefits to trickle-down: International children’s rights under a land claim agreement." International Journal of Children’s Rights 21, no. 4 (2013): 543–68. http://dx.doi.org/10.1163/157181812x652616.

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The Inuit of Nunavut, Canada, are the intended beneficiaries of several overlapping rights frameworks. The international treaties to which Canada is a signatory, the Nunavut Land Claim Agreement, the United Nations Declaration on the Rights of Indigenous People, Canada’s Constitution and a slate of federal and territorial laws promise Inuit that they may enjoy the same opportunities to flourish that other Canadians enjoy. While these rights regimes and ensuing federal policies have developed in response to Inuit as a group, Inuit children have remained largely invisible. Among other factors, the fixation with economic development and the failure to promote the participation of children has contributed to the absence of their specific interests in plans for Nunavut’s future. As a result, this subgroup continues to suffer infringements of those rights that are most relevant to their success. Whereas these overlapping frameworks have the potential to greatly benefit a particularly marginalized group, in fact they have served to further confound efforts to promote and revitalize the welfare of Inuit children.
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Tuakli-Wosornu, Yetsa A., Demetri Goutos, Ioana Ramia, Natalie R. Galea, Margo Mountjoy, Katharina Grimm, and Sheree Bekker. "Development and validation of the athletes’ rights survey." BMJ Open Sport & Exercise Medicine 7, no. 4 (November 2021): e001186. http://dx.doi.org/10.1136/bmjsem-2021-001186.

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A recognised imbalance of power exists between athletes and sporting institutions. Recent cases of systemic athlete abuse demonstrate the relationship between power disparities and harassment and abuse in sport. Embedding human rights principles into sporting institutions is a critical step towards preventing harassment and abuse in sport. In 2017, the World Players Association (WPA) launched the Universal Declaration of Player Rights. A year later, the International Olympic Committee (IOC) developed their Athletes’ Rights and Responsibilities Declaration. These two documents codify benchmarks ‘for international sporting organisations to meet their obligations to protect, respect and guarantee the fundamental rights of players’. This paper is the first project exploring athletes’ knowledge, understanding and awareness of rights in the sports context. This study presents the development and validation of a survey investigating athletes’ knowledge of these declarations, associated attitudes/beliefs and understanding of how these rights can be enacted in practice. The survey includes 10 statements of athlete rights based on the WPA and IOC declarations. Face validation was assessed by distributing the survey to 10 athletes and conducting qualitative interviews with a subgroup of four athletes. The survey was reworked into 13 statements, and the tool was validated with 611 responses through confirmatory factor analysis. Key findings include a weak correlation between athletes’ knowledge and their attitudes/beliefs, and challenges with the interpretation of words such as ‘pressure,’ ‘violence,’ ‘harassment’ and ‘intimidation.’ This validation puts forward the first survey instrument to directly test athletes’ knowledge, attitudes and beliefs about rights in sport.
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Schneider, Nina. "The forgotten voices of the militares cassados in Brazil." Brasiliana: Journal for Brazilian Studies 2, no. 2 (November 15, 2013): 313–44. http://dx.doi.org/10.25160/bjbs.v2i2.8297.

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Forcibly retired military officials whose political rights were withdrawn (militares cassados) during the military regime have previously received no attention from either the military institution or civilians (the State, the general public, and scholars). It is only recently that the Brazilian Truth Commission appointed a subgroup to investigate the militares cassados and that new research projects have been initiated. This article asks why research on military repression has been neglected for so long, and discusses three hypotheses. It then introduces two militares cassados ─ Brigadier Rui Moreira Lima, whose political rights were withdrawn despite his distinguished military career in the Second World War; and Ivan Proença Cavalcanti, a military official who defied instructions from his superiors to open fire on students. Based on oral history interviews, autobiographies, military journals, and intelligence files, this article aims to kick-start a discussion about whether the neglect of the militares cassados may be symptomatic of a historiographical tendency to homogenise the Armed Forces in Brazil.
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Pincetl, S. "Challenges to Citizenship: Latino Immigrants and Political Organizing in the Los Angeles Area." Environment and Planning A: Economy and Space 26, no. 6 (June 1994): 895–914. http://dx.doi.org/10.1068/a260895.

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Los Angeles County is home to over 700000 undocumented residents, largely from Mexico and Central America. They are largely poor and live in segregated neighborhoods. As they have entered the country illegally they have no citizenship rights. Yet the political system in the United States rests on the assumptions of democratic consent and citizen participation. When there is an increasing divergence between the population as a whole and an increasingly unrepresented politically active subgroup, the legitimacy of the political system itself is in jeopardy. In this paper, the political and economic organizing among undocumented Latino residents is examined, and questions are raised about the reformulation of the notion of citizenship.
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Dissertations / Theses on the topic "Subgroup rights"

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Nolan, Mark Andrew, and mark nolan@anu edu au. "Construals of Human Rights Law: Protecting Subgroups As Well As Individual Humans." The Australian National University. Faculty of Science, 2003. http://thesis.anu.edu.au./public/adt-ANU20050324.155005.

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This research develops the social psychological study of lay perception of human rights and of rights-based reactions to perceived injustice. The pioneering work by social representation theorists is reviewed. Of particular interest is the use of rights-based responses to perceived relative subgroup disadvantage. It is argued that these responses are shaped by the historical development of the legal concept of unique subgroup rights; rights asserted by a subgroup that cannot be asserted by outgroup members or by members of a broader collective that includes all subgroups. The assertion of unique subgroup rights in contrast to individual rights was studied by presenting participants with scenarios suggestive of human rights violations. These included possible violations of privacy rights of indigenous Australians (Study 1), civil and political rights of indigenous Australians under mandatory sentencing schemes (Study 2), privacy rights of students in comparison to public servants (Study 3), refugee rights (Study 4), and reproductive rights of lesbians and single women in comparison to married women and women in de facto relationships (Study 5). The scenarios were based on real policy issues being debated in Australia at the time of data collection. Human rights activists participated in Studies 4 and 5. In Study 5, these activists participated via an online, web-based experiment. Both quantitative and qualitative data were collected. A social identity theory perspective is used drawing on concepts from both social identity theory and self-categorization theory. The studies reveal a preference for an equality-driven construal of the purpose of human rights law (i.e. that all Australians be treated equally regardless of subgroup membership) in contrast to minority support for a vulnerable groups construal of the purpose of human rights (i.e. that the purpose of human rights law is to protect vulnerable subgroups within a broader collective). Tajfelian social belief orientations of social mobility and social change are explicitly measured in Studies 3-5. Consistent with the social identity perspective, these ideological beliefs are conceptualised as background knowledge relevant to the subjective structuring of social reality (violation contexts) and to the process of motivated relative perception from the vantage point of the perceiver. There is some indication from these studies that social belief orientation may determine construals of the purpose of human rights. In Study 5 the observed preference for using inclusive human rights rhetoric in response to perceived subgroup injustice is explained as an identity-management strategy of social creativity. In Studies 4 and 5, explicit measurement of activist identification was also made in an attempt to further explain the apparently-dominant preference for an equality-driven construal of the purpose of human rights law and the preferred use of inclusive, individualised rights rhetoric in response to perceived subgroup injustice. Activist identification explained some action preferences, but did not simply translate into preferences for using subgroup interest arguments. In Study 5, metastereotyping measures revealed that inclusive rights-based protest strategies were used in order to create positive impressions of social justice campaigners in the minds of both outgroup and ingroup audiences. Ideas for future social psychological research on human rights is discussed.
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Crosby, Peter. "Right Engel subgroups." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545314.

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In this thesis we find deep results on the structure of normal right n-Engel subgroups that are contained in some term of the upper central series of a group. We start with some known results, and one new result, on the structure of locally nilpotent n-Engel groups. These are closely related to the solution of the restricted Burnside problem. We also give specific details of the structure of 2-Engel and 3-Engel groups in the context of these results. The main idea of this thesis is to generalise these results to apply to normal upper central right n-Engel subgroups. We also consider the special case of locally finite p-groups and again generalise some deep results on the structure of n-Engel such groups to apply to right n-Engel subgroups. For each of the theorems on right n-Engel subgroups, complete details are given for the case n = 2. Right 3-Engel subgroups have a more complicated structure. For these we prove a Fitting result, for which we exclude the prime 3, and using this we also find a sharp bound on the upper central degree in the torsion-free case. In fact we only need to exclude the primes 2, 3 and 5 for this result. This gives some further information on the structure of right 3-Engel subgroups in the context of the main theorems.
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Nolan, Mark Andrew. "Construals of human rights law protecting subgroups as well as individual humans /." Connect to this title online, 2003. http://thesis.anu.edu.au/public/adt-ANU20050324.155005/.

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Eichler, Jessika. "The vernacularisation of indigenous peoples' participatory rights in the Bolivian extractive sector : including subgroups in collective decision-making processes." Thesis, University of Essex, 2016. http://repository.essex.ac.uk/19121/.

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One of the most comprehensive collective rights regimes has been developed in the area of indigenous peoples and respective land and resource rights in particular. International legal instruments (ILO C169 and UNDRIPS) and Inter-American jurisprudence (e.g. the Saramaka and Sarayaku cases) significantly safeguard such rights. The latter materialise in the form of prior consultation mechanisms regarding natural resource extraction and ultimately exemplify indigenous peoples’ self-determination. However, practice shows that such collective mechanisms are established without truly taking indigenous peoples’ representative institutions according to their customs and traditions into account. This can be attributed to the fact that the interplay and local dynamics between indigenous communities, leaders and representative organisations are too complex to be reduced to collective wholes. In order to disentangle such dynamics, power relations between the players, issues of legitimacy, representativity and accountability of participatory mechanisms, and the inclusion of subgroups and individuals in collective decision-making are examined. By combining international legal standards and ethnographic research, a legal anthropological perspective informs this piece of research. Firstly, insights are gained by understanding individual or ‘subgroup’ rights in relation to collective claims in international and regional legal standards. Secondly, this relationship is observed by means of two case studies in the Bolivian Lowlands that shall shed light upon the implementation of such standards in the extractive sector. Thereby, specific subgroups are chosen to illustrate participatory exclusion and inequalities, including women (I), different age groups (II), monolingual people and persons with lower education levels (III) and local leaders (IV). Empirical insights draw on a prior consultation process with Guaraní people in the hydrocarbon sector and collective decision-making mechanisms in the case of Chiquitano people in the mining sector. Based on such empirical observations, a catalogue of guiding principles will be proposed in order to refine the existing UNDRIPS framework.
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Nolan, Mark. "Construals of Human Rights Law: Protecting Subgroups As Well As Individual Humans." Phd thesis, 2003. http://hdl.handle.net/1885/47996.

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This research develops the social psychological study of lay perception of human rights and of rights-based reactions to perceived injustice. The pioneering work by social representation theorists is reviewed. Of particular interest is the use of rights-based responses to perceived relative subgroup disadvantage. It is argued that these responses are shaped by the historical development of the legal concept of unique subgroup rights; rights asserted by a subgroup that cannot be asserted by outgroup members or by members of a broader collective that includes all subgroups. ¶ ...
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Books on the topic "Subgroup rights"

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Damhuis, Koen. Roads to the Radical Right. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198863632.001.0001.

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Trump, Wilders, Salvini, Le Pen—during the last decades, radical right-wing leaders and their parties have become important political forces in most Western democracies. Their growing appeal raises an increasingly relevant question: who are the voters that support them and why do they do so? Numerous and variegated answers have been given to this question, inside as well as outside academia. Yet, curiously, despite their quantity and diversity, these existing explanations are often based on a similar assumption: that of homogeneous electorates. Consequently, the idea that different subgroups with different profiles and preferences might coexist within the constituencies of radical right-wing parties has thus far remained underdeveloped, both theoretically and empirically. This ground-breaking book is the first one that systematically investigates the heterogeneity of radical right-wing voters. Theoretically, it introduces the concept of electoral equifinality to come to grips with this diversity. Empirically, it relies on innovative statistical analyses and no less than 125 life-history interviews with voters in France and the Netherlands. Based on this unique material, the study identifies different roads to the radical right and compares them within a cross-national perspective. In addition, through an analysis of almost 1,400 tweets posted by Geert Wilders and Marine Le Pen, the book shows how the latter are able to appeal to different groups of voters. Taken together, the book thus provides a host of ground-breaking insights into the heterogeneous phenomenon of radical right support.
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Goodall, Alex. American Fascism. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252038037.003.0009.

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This chapter discusses how there was no single path to fascism in America. Explanations for the rising influence of anti-Semitic, conspiratorial, and antidemocratic ideas on the extreme Right in the 1930s often focus on the unique characteristics of particular subgroups: the conspiratorial methodology of Protestant fundamentalist Bible decoders, the corporatist traditions of the Catholic Church, and the totalitarian ethic of big businessmen like Ford. But none of these explanations entirely satisfies, since other individuals in each of these communities did not respond in the same way. Political defeat clearly played its part in the formation of the rejectionist consciousness of extremists; again, though, other individuals experienced political exclusion without needing fascistic ideas to reconcile themselves to a hostile world.
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Kimonis, Eva R., and Georgette E. Fleming. Disruptive and Conduct Disorders, Delinquency. Edited by Thomas H. Ollendick, Susan W. White, and Bradley A. White. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190634841.013.27.

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Disruptive and conduct disorders, comprising oppositional defiant disorder and conduct disorder, are characterized by behaviors that violate the rights of others or bring the individual into significant conflict with societal norms or authority figures. These disorders are highly prevalent, emerge early in childhood, and are associated with profound disability and societal burden. Given the heterogeneity in presentation and outcomes of youth with disruptive and conduct disorders, attempts have been made to identify more homogeneous subgroups. Notably, children displaying callous–unemotional traits (e.g., lack of empathy, remorse/guilt) represent a distinct group with severe, aggressive, and chronic conduct problems. To identify this and other important clinical considerations, it is imperative that conduct problem assessment is effective and comprehensive. Assessment findings should inform implementation of evidence-based treatment tailored to the child’s and family’s individual needs. Additional clinical considerations and recommendations for the next frontiers of research into disruptive and conduct disorders are discussed.
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Howell, Simon J. Clinical trial designs in anaesthesia. Edited by Jonathan G. Hardman. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0030.

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A clinical trial is a research study that assigns people or groups to different interventions and compares the impact of these on health outcomes. This chapter examines the design and delivery of clinical trials in anaesthesia and perioperative medicine covering the issues outlined below. The features of a high-quality clinical trial include well-defined inclusion and exclusion criteria, a control group, randomization, and blinding. Outcome measures may be broadly divided into counting the number of people who experience an outcome and taking measurements on people. The outcome measures selected for a clinical trial reflect the purpose of the study and may include ‘true’ clinical measures such as major postoperative complications or surrogate measures such as the results of a biochemical test. Outcome measures may be combined in a composite outcome. Assessment of health-related quality of life using a tool such as the SF-36 questionnaire is an important aspect of many clinical trials in its own right and also informs the economic analyses that may be embedded in a trial. Determining the number for recruits needed for a clinical trial requires both clinical and statistical insight and judgement. The analysis of a clinical trial requires a similarly sophisticated approach that takes into account the objectives of the study and balances the need for appropriate subgroup analyses with the risk of false-positive results. The safe and effective management of a clinical trial requires rigorous organizational discipline and an understanding of the ethical and regulatory structures that govern clinical research.
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Galiè, Nazzareno, Alessandra Manes, and Massimiliano Palazzini. Pulmonary hypertension. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0065.

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Pulmonary hypertension is a haemodynamic and pathophysiological condition defined as an increase in the mean pulmonary arterial pressure of ≥25 mmHg at rest, as assessed by right heart catheterization. In fact, while transthoracic echocardiography may provide clues on the presence of pulmonary hypertension, the haemodynamic evaluation offers a more precise and comprehensive assessment. Pulmonary hypertension is heterogeneous from a pathophysiological point of view, and the diversity is reflected in the haemodynamic definitions. The different haemodynamic forms of pulmonary hypertension can be found in multiple clinical conditions which have been classified into six main groups and at least twenty-six subgroups. Each main clinical group shows specific pathological changes in the lung distal arteries, capillaries, and small veins. If we combine the haemodynamic and clinical heterogeneity, we understand the complexity of an accurate diagnosis in the individual patient which is crucial for the prognostic assessment and treatment strategy. In addition, the concomitant presence of different haemodynamic and clinical mechanisms cannot be excluded in individual cases (e.g. in patients with congestive heart failure and associated lung diseases). The presence of pulmonary hypertension, as defined above, is always an ominous prognostic sign, even if the severity may differ according to the haemodynamic changes and underlying clinical condition. The therapeutic approach also is markedly different, according to the clinical group, and symptomatic and haemodynamic severity. For these reasons, the four more frequent clinical groups are discussed individually, while the classifications are described in the Introduction section.
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Book chapters on the topic "Subgroup rights"

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Ben-Shahar, Omri, and Ariel Porat. "Personalized Regulatory Techniques." In Personalized Law, 85–104. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197522813.003.0005.

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This chapter expands the demonstration how personalized law would transform existing legal institutions. The chapter shifts the focus from specific doctrines to regulatory techniques. These are generic approaches to the design of legal interventions, used in every area of law. The chapter examines the personalization of several techniques: default rules, mandated disclosures, compensatory damages, and bundles of rights. With each of these tools, the law presently prescribes one-size-fits-all rules, designed to either best fit the average person, or to promote the interests of a specific subgroup of the population. By shifting to personalized rules, the law could simultaneously advance the interests of different groups and individuals. The chapter shows that designing personalized default rules, disclosures, damages, or bundles of rights would promote the goals underlying these interventions. Personalized default would mimic peoples’ preferences more successfully and reduce the incidence of opt-out. Personalized disclosures stand a chance of being more useful to people. Personalized compensation would come closer to making victims of wrongs whole. And personalized bundles of rights would recognize the diversity of people’s interests and aspirations.
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Londyn Menkes, Daniel. "Climate Change: A Forced Choice Ethical Paradigm." In Bioethics in Medicine and Society. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95486.

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Notwithstanding the political debates in the media, climate change presents a unique set of ethical challenges faced by all the planet’s inhabitants. To understand the current challenges facing humanity, it is important to retrace the evolution of human society as this underlies the ethical foundations that internalize a group’s beliefs and norms. Humans have modified the environment on a global scale that is unsustainable that has resulted in climate change-a disease process with dire implications. Understanding the root causes of a disease process is the best means of devising a treatment plan. Climate change solutions must be syntonic with a biopsychosocial model that addresses culture and belief systems. The six main ethical theories-utilitarianism, egoism, deontology, virtue, divine command, and relativism all have their inherent flaws. Beauchamp and Childress concatenated these constructs into the four main bioethical principles of autonomy, beneficence, non-malfeasance, and justice. Of these, autonomy is least applicable to climate change as decisions made by a subgroup of one species will have an impact on all terrestrial lifeforms both present and future. Humanity must accept the reality of climate change and effect solutions based on these four principles. Failure to act will lead to catastrophic climate changes that may lead to the sixth mass extinction. Effective climate change solutions must embrace an integrative approach by supporting leaders who will embrace science and will advocate for universal human rights.
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Bell, Robert W., and Matt Clay. "Right-Angled Artin Groups." In Office Hours with a Geometric Group Theorist. Princeton University Press, 2017. http://dx.doi.org/10.23943/princeton/9780691158662.003.0014.

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This chapter deals with right-angled Artin groups, a broad spectrum of groups that includes free groups on one end, free abelian groups on the other end, and many other interesting groups in between. A right-angled Artin group is a group G(Γ‎) defined in terms of a graph Γ‎. Right-angled Artin groups have taken a central role in geometric group theory, mainly due to their involvement in the solution to one of the main open questions in the topology of 3-manifolds. The chapter first considers right-angled Artin groups as subgroups and how they relate to other classes of groups before exploring subgroups of right-angled Artin groups and the word problem for right-angled Artin groups. The discussion includes exercises and research projects.
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Yue, Mu. "Sparse Boosting Based Machine Learning Methods for High-Dimensional Data." In Computational Statistics and Applications. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.100506.

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In high-dimensional data, penalized regression is often used for variable selection and parameter estimation. However, these methods typically require time-consuming cross-validation methods to select tuning parameters and retain more false positives under high dimensionality. This chapter discusses sparse boosting based machine learning methods in the following high-dimensional problems. First, a sparse boosting method to select important biomarkers is studied for the right censored survival data with high-dimensional biomarkers. Then, a two-step sparse boosting method to carry out the variable selection and the model-based prediction is studied for the high-dimensional longitudinal observations measured repeatedly over time. Finally, a multi-step sparse boosting method to identify patient subgroups that exhibit different treatment effects is studied for the high-dimensional dense longitudinal observations. This chapter intends to solve the problem of how to improve the accuracy and calculation speed of variable selection and parameter estimation in high-dimensional data. It aims to expand the application scope of sparse boosting and develop new methods of high-dimensional survival analysis, longitudinal data analysis, and subgroup analysis, which has great application prospects.
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Escudero, Kevin. "The Identity Mobilization Model." In Organizing While Undocumented, 19–48. NYU Press, 2020. http://dx.doi.org/10.18574/nyu/9781479803194.003.0002.

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This chapter provides an overview of the book’s organizing theoretical framework, the Identity Mobilization Model, includes an overview of the sites where fieldwork for the book was conducted, and details the histories of the three subgroups whose experiences are the main focus of the book. The Identity Mobilization Model combines social movement research on education, strategy, and allyship to explain how members of a marginalized group who do not hold formal recognition under the law contest this form of exclusion and fight for increased rights. The discussion of the book’s multisited ethnographic approach, which is based on fieldwork conducted in San Francisco, Chicago, and New York City, highlights the similarity of each city with regard to the welcoming environment it provides for undocumented community members. The chapter concludes with a detailed background of the three subgroups within the immigrant rights movement that the book’s ethnographic chapters focus on: Asian undocumented immigrants, undocuqueer immigrants, and formerly undocumented women.
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Ritter, Michael. "Voting Rights, Election Administration, and Turnout for Racial Minorities." In Accessible Elections, 91–110. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780197537251.003.0006.

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Race and ethnicity group identity also shape participation in politics, with non-Hispanics whites being the most likely to vote in U.S. elections over time. Can accessible elections shrink turnout inequality between non-Hispanic whites and racial/ethnic minorities (African Americans, Hispanic Americans, and Asian Americans)? Chapter 6 empirically evaluates the impact of convenience voting laws and election administration on the change in the probably of voting in midterm and presidential elections comparing across racial subgroups. The results show that same day registration boosts turnout among non-Hispanics whites, as well as Asian Americans, Hispanics, and African Americans, in presidential and midterm elections. Early in-person voting especially advantages blacks and Hispanics in midterm elections, while absentee/mail voting is found to have similar effects for Asian Americans. Both non-Hispanic whites and racial and ethnic minorities benefit from quality state election administration.
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Dadisman, Amy K., Noah D. Andrews, Reena Mehra, and Irene L. Katzan. "Sooner Than Later If Not Right After Stroke." In Sleep Disorders, 927–50. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190671099.003.0055.

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The case involves a patient with interrelated sleep symptoms related to central hypersomnia, restless legs syndrome, and sleep disordered breathing (SDB) occurring after stroke. The prevalence of SDB after stroke has been noted to be very high, up to 70%, and consists of a higher contribution of central sleep apnea compared to the general population. Recurrent stroke is associated with a higher prevalence of SDB compared to first-time stroke. Contributions to SDB as related to stroke do not appear to have consistencies in terms of location and size of stroke. Untreated SDB can also contribute to stroke risk, with mechanisms involving increased systemic inflammation, prothrombotic biochemical markers, and dysfunction of cerebral autoregulation. Although there are post-hoc subgroup data in a randomized controlled trial suggesting reduction in stroke outcomes when SDB is treated with positive airway pressure, overall there are few studies that have rigorously examined the impact of treatment. Hypersomnia can be treated with modafinil and restless legs syndrome may become manifest due to sleep fragmentation.
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Kamen, Deborah. "Metics (Metoikoi)." In Status in Classical Athens. Princeton University Press, 2013. http://dx.doi.org/10.23943/princeton/9780691138138.003.0005.

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This chapter turns to metoikoi, foreigners who, unlike xenoi, were official residents of Athens, rather than just passing through. In its broad sense, the term metoikos encompassed two subcategories of resident alien, distinguished from each other not only legally but also socially: (i) freeborn foreigners (metoikoi or metics in the narrow sense); and (ii) freed slaves, most likely those who were not (or who were no longer) bound to their previous masters. These two subcategories of metic share a number of traits, the most obvious of which was their non-Athenian origin. Both subgroups of metic also had many of the rights and obligations of citizens. They were expected to obey the city's laws and were obligated to perform military service.
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Guadalupe-Diaz, Xavier L., and Carolyn M. West. "The Intersections of Race and Immigration." In Transgender Intimate Partner Violence, 133–66. NYU Press, 2020. http://dx.doi.org/10.18574/nyu/9781479830428.003.0006.

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As in the cisgender intimate partner violence (C-IPV) literature, transgender IPV (T-IPV) is often presented as a one-size-fits-all phenomenon, where all transgender survivors experience the same IPV tactics and barriers to escape. Consequently, IPV victim service providers may falsely assume that most transgender survivors are white, native-born citizens. In reality, transgender survivors who are people of color, immigrants, and/or undocumented face a variety of unique IPV tactics and barriers to escape shaped by racism, xenophobia, language challenges, and fewer legal rights. This chapter reviews the still-emerging body of research on T-IPV and intersectionality, specifically the intersections of race and immigration, supplemented by studies on race and immigration in the C-IPV literature. Ultimately, this literature emphasizes the need for tailoring IPV victim services to the unique needs of various transgender subgroups.
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Marcy, Richard T. "Why the Alt Right Is Not Going Anywhere (Regardless of What We Call It)." In The Vanishing Tradition, 109–21. Cornell University Press, 2020. http://dx.doi.org/10.7591/cornell/9781501749858.003.0009.

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This chapter investigates the Alt Right and how it has developed as a response to the perceived inadequacies of the authorized conservative movement. It focuses primarily on its psychological and cultural aspects. As the Alt Right comprises a number of different groups, each serving its own strategic purpose and distinct audience, it might be useful to unpack some of the different roles that individuals and groups are playing within the movement; one might then better understand the strategies and tactics of those individuals and subgroups. The chapter then cites examples of these tactics—for example, provocations leading to moral outrage from the Left and Republican establishment—and situates them within a broader cultural war. It stresses the efforts of a marginalized group to attract attention through outrageous gestures while at the same time aiming to join the political conversation. The chapter draws on relevant psychological and sociological literature and integrates historical scholarship dealing with earlier artistic-political avant-garde movements and their revolts against mainstream culture.
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Conference papers on the topic "Subgroup rights"

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Widmer, L. K., M. Th Widmer, E. Zemp, F. Duckert, G. Marbet, H. E. Schmitt, E. Brandenberg, and R. Voëlin. "LONG-TERM MORBIDITY AFTER DEEP VEIN THROMBOSIS (DVT)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642969.

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5 yr follow-up of 341 patients with special consideration of post-thrombotic syndrome (PTS) and methodolo-cigal difficulties.INTRODUCTIONMethodological difficulties responsable for lacking unité de doctrine: (a) Acute phase: random allocation taking into account DVT of different extent; assessment of effect of treatment (b) Follow-up: drop out definition of parameters of success esp. PTS, comparison of truely comparable groups, limited information about economic aspects.5 yr FOLLOW-UP PTS-INCIDENCE after ANTICOAGULATION (AC) or THROMBOLYSIS (TL)Method: 341 non-randomized, consecutive patients; unilateral DVT documented by initial and control-phlebo-gramm (<14 d) , treated by AC or thrombolytic agents. 226 men, 115 women, 51.9 ± 16 yr at entry. DVT: left 193, right 148; limited 35 %, extended 65 %. Treatment effect by analysis “vein per vein”. Re-examination: “blind technique” by 2 observers; definition of PTS considering corona phlebectatica, cyanosis, edema, cirumference difference, trophic changes; Score > 10= PTSResults:1. Group with unchanged initial and control phlebogrammCorrelation between DVT-extent at entry and PTS-incidence (table). Consequently comparison of AC and TL must be made between subgroups with similar DVT-extent at entry.2. Subgroups with clearance ( + ) vs. non-clearance ( - ):Figures white PTS without ulcera, black leg ulcer
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Behr, J., M. Kolb, JW Song, F. Luppi, B. Schinzel, S. Stowasser, M. Quaresma, and FJ Martinez. "Nintedanib plus sildenafil versus nintedanib alone in patients with IPF and severely impaired gas exchange: subgroup analysis by right heart dysfunction*." In 61. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3403295.

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Behr, J., M. Kolb, J. W. Song, F. Luppi, B. Schinzel, S. Stowasser, M. Quaresma, F. J. Martinez, and for the INSTAGE trial investigators. "Nintedanib Plus Sildenafil Versus Nintedanib Alone in Patients with IPF and Severely Impaired Gas Exchange: Subgroup Analysis by Right Heart Dysfunction." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2637.

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White, Eric, Jürgen Behr, Martin Kolb, Toby M. Maher, Carina Ittrich, Claudia Diefenbach, Klaus B. Rohr, Manuel Quaresma, and Bruno Crestani. "Changes in biomarkers with nintedanib and sildenafil in subjects with IPF in the INSTAGE trial: subgroup analysis by right heart dysfunction (RHD)." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.731.

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Reports on the topic "Subgroup rights"

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Hart, Tim, J. Mary Wickenden, Stephen Thompson, Gary Pienaar, Tinashe Rubaba, and Narnia Bohler-Muller. Literature Review to Support a Survey to Understand the Socio-economic, Wellbeing and Human Rights Related Experiences of People with Disabilities During Covid-19 Lockdown in South Africa. Institute of Development Studies (IDS), February 2022. http://dx.doi.org/10.19088/ids.2022.012.

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COVID-19 pandemic and associated national responses have had ramifications for societies around the world, including South Africa. The marginalisation of people with disabilities is well documented in pre-COVID times, and emerging evidence suggests that the crisis has made this worse, as well as presenting new challenges for people with disabilities. This paper presents a review of published research and grey literature of relevance to the proven or anticipated socio-economic, wellbeing and human right related impacts of COVID-19 on people with disabilities in South Africa and other contexts. Its purpose is to summarise evidence to inform a study on the experiences of South Africans with disabilities during the COVID-19 pandemic and the development of an improved inclusive framework for future management of such crises in South Africa. After a brief introduction, the paper is structured around four main sections. Context is provided by considering COVID-19 and disability both globally and in Africa. Then the literature focused on Humanitarian Disaster Risk Reduction and disability inclusion is discussed. Finally the South African policy and legislation environment on disability and humanitarian action is explored. The review finds that globally there is a limited but growing body of work on COVID-19 and disability. There is a particular dearth of evidence focusing specifically on Africa. The evidence that does exist tends either to be focused on a few particular countries or form part of large global surveys. Much of the global level grey literature published early in the pandemic and subsequently anticipates exacerbated negative experiences for people with disabilities, including exclusion from services, stigma and discrimination and lack of inclusive approaches to relief and support by governments and others. Advisory materials, sometimes focussed on specific subgroups, are generally in agreement about calling for a universally inclusive and disability aware approach to pandemic mitigation across settings and sectors. The limited primary research on COVID-19 and disability is mostly focussed on high income settings and or populations with particular health concerns.
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Rankin, Nicole, Deborah McGregor, Candice Donnelly, Bethany Van Dort, Richard De Abreu Lourenco, Anne Cust, and Emily Stone. Lung cancer screening using low-dose computed tomography for high risk populations: Investigating effectiveness and screening program implementation considerations: An Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for the Cancer Institute NSW. The Sax Institute, October 2019. http://dx.doi.org/10.57022/clzt5093.

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Background Lung cancer is the number one cause of cancer death worldwide.(1) It is the fifth most commonly diagnosed cancer in Australia (12,741 cases diagnosed in 2018) and the leading cause of cancer death.(2) The number of years of potential life lost to lung cancer in Australia is estimated to be 58,450, similar to that of colorectal and breast cancer combined.(3) While tobacco control strategies are most effective for disease prevention in the general population, early detection via low dose computed tomography (LDCT) screening in high-risk populations is a viable option for detecting asymptomatic disease in current (13%) and former (24%) Australian smokers.(4) The purpose of this Evidence Check review is to identify and analyse existing and emerging evidence for LDCT lung cancer screening in high-risk individuals to guide future program and policy planning. Evidence Check questions This review aimed to address the following questions: 1. What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? 2. What is the evidence of potential harms from lung cancer screening for higher-risk individuals? 3. What are the main components of recent major lung cancer screening programs or trials? 4. What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Summary of methods The authors searched the peer-reviewed literature across three databases (MEDLINE, PsycINFO and Embase) for existing systematic reviews and original studies published between 1 January 2009 and 8 August 2019. Fifteen systematic reviews (of which 8 were contemporary) and 64 original publications met the inclusion criteria set across the four questions. Key findings Question 1: What is the evidence for the effectiveness of lung cancer screening for higher-risk individuals? There is sufficient evidence from systematic reviews and meta-analyses of combined (pooled) data from screening trials (of high-risk individuals) to indicate that LDCT examination is clinically effective in reducing lung cancer mortality. In 2011, the landmark National Lung Cancer Screening Trial (NLST, a large-scale randomised controlled trial [RCT] conducted in the US) reported a 20% (95% CI 6.8% – 26.7%; P=0.004) relative reduction in mortality among long-term heavy smokers over three rounds of annual screening. High-risk eligibility criteria was defined as people aged 55–74 years with a smoking history of ≥30 pack-years (years in which a smoker has consumed 20-plus cigarettes each day) and, for former smokers, ≥30 pack-years and have quit within the past 15 years.(5) All-cause mortality was reduced by 6.7% (95% CI, 1.2% – 13.6%; P=0.02). Initial data from the second landmark RCT, the NEderlands-Leuvens Longkanker Screenings ONderzoek (known as the NELSON trial), have found an even greater reduction of 26% (95% CI, 9% – 41%) in lung cancer mortality, with full trial results yet to be published.(6, 7) Pooled analyses, including several smaller-scale European LDCT screening trials insufficiently powered in their own right, collectively demonstrate a statistically significant reduction in lung cancer mortality (RR 0.82, 95% CI 0.73–0.91).(8) Despite the reduction in all-cause mortality found in the NLST, pooled analyses of seven trials found no statistically significant difference in all-cause mortality (RR 0.95, 95% CI 0.90–1.00).(8) However, cancer-specific mortality is currently the most relevant outcome in cancer screening trials. These seven trials demonstrated a significantly greater proportion of early stage cancers in LDCT groups compared with controls (RR 2.08, 95% CI 1.43–3.03). Thus, when considering results across mortality outcomes and early stage cancers diagnosed, LDCT screening is considered to be clinically effective. Question 2: What is the evidence of potential harms from lung cancer screening for higher-risk individuals? The harms of LDCT lung cancer screening include false positive tests and the consequences of unnecessary invasive follow-up procedures for conditions that are eventually diagnosed as benign. While LDCT screening leads to an increased frequency of invasive procedures, it does not result in greater mortality soon after an invasive procedure (in trial settings when compared with the control arm).(8) Overdiagnosis, exposure to radiation, psychological distress and an impact on quality of life are other known harms. Systematic review evidence indicates the benefits of LDCT screening are likely to outweigh the harms. The potential harms are likely to be reduced as refinements are made to LDCT screening protocols through: i) the application of risk predication models (e.g. the PLCOm2012), which enable a more accurate selection of the high-risk population through the use of specific criteria (beyond age and smoking history); ii) the use of nodule management algorithms (e.g. Lung-RADS, PanCan), which assist in the diagnostic evaluation of screen-detected nodules and cancers (e.g. more precise volumetric assessment of nodules); and, iii) more judicious selection of patients for invasive procedures. Recent evidence suggests a positive LDCT result may transiently increase psychological distress but does not have long-term adverse effects on psychological distress or health-related quality of life (HRQoL). With regards to smoking cessation, there is no evidence to suggest screening participation invokes a false sense of assurance in smokers, nor a reduction in motivation to quit. The NELSON and Danish trials found no difference in smoking cessation rates between LDCT screening and control groups. Higher net cessation rates, compared with general population, suggest those who participate in screening trials may already be motivated to quit. Question 3: What are the main components of recent major lung cancer screening programs or trials? There are no systematic reviews that capture the main components of recent major lung cancer screening trials and programs. We extracted evidence from original studies and clinical guidance documents and organised this into key groups to form a concise set of components for potential implementation of a national lung cancer screening program in Australia: 1. Identifying the high-risk population: recruitment, eligibility, selection and referral 2. Educating the public, people at high risk and healthcare providers; this includes creating awareness of lung cancer, the benefits and harms of LDCT screening, and shared decision-making 3. Components necessary for health services to deliver a screening program: a. Planning phase: e.g. human resources to coordinate the program, electronic data systems that integrate medical records information and link to an established national registry b. Implementation phase: e.g. human and technological resources required to conduct LDCT examinations, interpretation of reports and communication of results to participants c. Monitoring and evaluation phase: e.g. monitoring outcomes across patients, radiological reporting, compliance with established standards and a quality assurance program 4. Data reporting and research, e.g. audit and feedback to multidisciplinary teams, reporting outcomes to enhance international research into LDCT screening 5. Incorporation of smoking cessation interventions, e.g. specific programs designed for LDCT screening or referral to existing community or hospital-based services that deliver cessation interventions. Most original studies are single-institution evaluations that contain descriptive data about the processes required to establish and implement a high-risk population-based screening program. Across all studies there is a consistent message as to the challenges and complexities of establishing LDCT screening programs to attract people at high risk who will receive the greatest benefits from participation. With regards to smoking cessation, evidence from one systematic review indicates the optimal strategy for incorporating smoking cessation interventions into a LDCT screening program is unclear. There is widespread agreement that LDCT screening attendance presents a ‘teachable moment’ for cessation advice, especially among those people who receive a positive scan result. Smoking cessation is an area of significant research investment; for instance, eight US-based clinical trials are now underway that aim to address how best to design and deliver cessation programs within large-scale LDCT screening programs.(9) Question 4: What is the cost-effectiveness of lung cancer screening programs (include studies of cost–utility)? Assessing the value or cost-effectiveness of LDCT screening involves a complex interplay of factors including data on effectiveness and costs, and institutional context. A key input is data about the effectiveness of potential and current screening programs with respect to case detection, and the likely outcomes of treating those cases sooner (in the presence of LDCT screening) as opposed to later (in the absence of LDCT screening). Evidence about the cost-effectiveness of LDCT screening programs has been summarised in two systematic reviews. We identified a further 13 studies—five modelling studies, one discrete choice experiment and seven articles—that used a variety of methods to assess cost-effectiveness. Three modelling studies indicated LDCT screening was cost-effective in the settings of the US and Europe. Two studies—one from Australia and one from New Zealand—reported LDCT screening would not be cost-effective using NLST-like protocols. We anticipate that, following the full publication of the NELSON trial, cost-effectiveness studies will likely be updated with new data that reduce uncertainty about factors that influence modelling outcomes, including the findings of indeterminate nodules. Gaps in the evidence There is a large and accessible body of evidence as to the effectiveness (Q1) and harms (Q2) of LDCT screening for lung cancer. Nevertheless, there are significant gaps in the evidence about the program components that are required to implement an effective LDCT screening program (Q3). Questions about LDCT screening acceptability and feasibility were not explicitly included in the scope. However, as the evidence is based primarily on US programs and UK pilot studies, the relevance to the local setting requires careful consideration. The Queensland Lung Cancer Screening Study provides feasibility data about clinical aspects of LDCT screening but little about program design. The International Lung Screening Trial is still in the recruitment phase and findings are not yet available for inclusion in this Evidence Check. The Australian Population Based Screening Framework was developed to “inform decision-makers on the key issues to be considered when assessing potential screening programs in Australia”.(10) As the Framework is specific to population-based, rather than high-risk, screening programs, there is a lack of clarity about transferability of criteria. However, the Framework criteria do stipulate that a screening program must be acceptable to “important subgroups such as target participants who are from culturally and linguistically diverse backgrounds, Aboriginal and Torres Strait Islander people, people from disadvantaged groups and people with a disability”.(10) An extensive search of the literature highlighted that there is very little information about the acceptability of LDCT screening to these population groups in Australia. Yet they are part of the high-risk population.(10) There are also considerable gaps in the evidence about the cost-effectiveness of LDCT screening in different settings, including Australia. The evidence base in this area is rapidly evolving and is likely to include new data from the NELSON trial and incorporate data about the costs of targeted- and immuno-therapies as these treatments become more widely available in Australia.
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