Relevant bibliographies by topics / STZ diabetic rats

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Academic literature on the topic 'STZ diabetic rats'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "STZ diabetic rats"

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Fernandes, Ana Angélica Henrique, Ethel Lourenzi Barbosa Novelli, Ary Fernandes Junior, and Cristiano Machado Galhardi. "Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats." Brazilian Archives of Biology and Technology 52, no. 1 (February 2009): 51–59. http://dx.doi.org/10.1590/s1516-89132009000100007.

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Amongst the numerous co-adjuvant therapies which could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of naringerin on biochemical parameters in streptozotocin-induced (STZ - 60 mg/kg, i.p.) diabetic rats. Male rats were divided into four groups: G1: untreated controls; G2: normal rats receiving naringerin; G3: untreated diabetics; G4: diabetics rats receiving naringerin. The naringerin (50mg/kg, i.p,) decreased the hyperglycaemia and hyperlipidaemia associated with STZ-diabetes. The concentrations of serum insulin in treated diabetic rats tended to be increased. Naringerin treatment prevents STZ-induced changes in the activities of ALT, AST and LDH in the liver and heart, indicating the protective effect of naringerin against the hepatic and cardiac toxicity caused by STZ. The glycogen level in cardiac and hepatic tissues elevated with naringerin in diabetic rats. The naringerin can improve the glucose and lipid metabolism and is beneficial in preventing diabetic complications.
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Yusuksawad, Mariem, and Narongsak Chaiyabutr. "The beneficial effect of long-term supplementation of vitamin C on renal mitochondrial disturbances in streptozotocin-induced diabetic rats." Asian Biomedicine 5, no. 2 (April 1, 2011): 277–82. http://dx.doi.org/10.5372/1905-7415.0502.038.

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Abstract Background: Oxidative stress induces renal dysfunction in diabetes, in which renal mitochondrial disturbance was implicated. Vitamin C (VC) supplementation may ameliorate the renal dysfunction in diabetics. However, it is not clear whether VC supplementation is effective for renal mitochondrial disturbances in diabetes. Objective: Investigate whether long-term continuous VC supplementation could ameliorate the renal mitochondrial disturbances in streptozotocin (STZ)-induced diabetic rats. Methods: Thirty-five male Sprague-Dawley rats were used, and diabetes was induced by an injection of STZ. The rats were divided into three groups: control rats (CON), STZ-induced diabetic rats (STZ), and diabetic rats supplemented by vitamin C (STZ-VC). The CON and STZ rats were given tap water, while STZ-VC rats received VC (1 g/L) every day for eight, 24 and 52 weeks. The kidney was isolated and homogenized. Oxygen comsumption (Vo2) was measured in mitochondria homogenate using an oxygen consumption monitor. Based on Vo2 tracings, the respiration control index (RCI) and P/O ratio (= ADP/ O ratio) were measured at week 8, 24 and 52. Results: At week eight, using either glutamate plus malate (for site I) or succinate (for site II) as substrates, both RCI and P/O ratio were not significantly different among three groups. The P/O ratio in STZ and STZ-VC rats increased from eight to 52 weeks after VC supplementation. At week 24, the P/O ratio at site II was normalized in STZ-VC rat. The increased P/O ratio (only site I) and the increased RCI (only site II) of STZ-VC rats were slower than those of STZ rats. Conclusion: Short-term VC supplementation might not influence the renal mitochondrial activity. The long-term VC supplementation could ameliorate the mitochondrial disturbances induced in STZ-induced diabetic rats.
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Yanardag, R., O. Ozsoy-Sacan, S. Bolkent, H. Orak, and O. Karabulut-Bulan. "Protective effects of metformin treatment on the liver injury of streptozotocin-diabetic rats." Human & Experimental Toxicology 24, no. 3 (March 2005): 129–35. http://dx.doi.org/10.1191/0960327104ht507oa.

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Metformin is a biguanide derivate used as an oral hypoglycaemic drug in diabetics. The aim of this study was to examine the histological and biochemical effects of metformin in streptozotocin (STZ)-treated rats. The animals were rendered diabetic by intraperitoneal injection of 65 mg/kg STZ. Fourteen days later, metformin was given at 25 mg/kg by gavage, daily for 28 days, to STZdiabetic rats and a control group. In the STZ-diabetic group, some degenerative changes were observed by light microscopic examination. But the degenerative changes were decreased in the STZ-diabetic group given metformin. In the STZ-diabetic group, blood glucose levels, serum alanine and aspartate transaminase (ALT and AST) activities, total lipid levels, and sodium and potassium levels increased, while body weight, serum magnesium levels and liver glutathione (GSH) levels decreased. In the STZ-diabetic group given metformin, blood glucose levels, serum ALT and AST activities, total lipid, and sodium and potassium levels decreased, and liver GSH and serum magnesium levels increased. As a result of all the morphological and biochemical findings obtained, it was concluded that metformin has a protective effect against the hepatotoxicity produced by STZ diabetes.
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Cheng, Daye, Bin Liang, and Yunhui Li. "Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/162724.

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TheGinkgo bilobaextract (GBE) has been reported to have a wide range of health benefits in traditional Chinese medicine. The aim of this study was to evaluate the antihyperglycemic effects of GBE on streptozotocin- (STZ-) induced diabetes in rats. Diabetes was induced in maleWistarrats by the administration of STZ (60 mg/kg b.w.) intraperitoneally. GBE (100, 200, and 300 mg/kg b.w.) was administered orally once a day for a period of 30 days. Body weight and blood glucose levels were determined in different experimental days. Serum lipid profile and antioxidant enzymes in hepatic and pancreatic tissue were measured at the end of the experimental period. Significant decreases in body weight and antioxidant ability and increases in blood glucose, lipid profile, and lipid peroxidation were observed in STZ-induced diabetic rats. The administration of GBE and glibenclamide daily for 30 days in STZ-induced diabetic rats reversed the above parameters significantly. GBE possesses antihyperglycemic, antioxidant, and antihyperlipidemia activities in STZ-induced chronic diabetic rats, which promisingly support the use of GBE as a food supplement or an adjunct treatment for diabetics.
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Tsai, Cheng-Chia, Kung-Shing Lee, Sheng-Hsien Chen, Li-Jen Chen, Keng-Fan Liu, and Juei-Tang Cheng. "Decrease of PPARδin Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury." PPAR Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/456386.

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Changes in the peroxisome proliferator-activated receptors-δ(PPARδ) expression in rats after spinal cord injury (SCI) have been previously reported. Diabetic animals show a higher mortality after SCI. However, the relationship between the progress of diabetes and PPARδin SCI remains unknown. In the present study, we used compressive SCI in streptozotocin-(STZ-) induced diabetic rats. GW0742, a PPARδagonist, was used to evaluate its merit in STZ rats after SCI. Changes in PPARδexpression were detected by Western blot. Survival rates were also estimated. A lower expression of PPARδin spinal cords of STZ-diabetic rats was observed. In addition, the survival times in two-week induction diabetes were longer than those in eight-week induction group, which is consistent with the expression of PPARδin the spinal cord. Moreover, GW0742 significantly increased the survival time of STZ rats. Furthermore, their motor function and pain response were attenuated by GSK0660, a selective PPARδantagonist, but were enhanced by GW0742. In conclusion, the data suggest that higher mortality rate in STZ-diabetic rats with SCI is associated with the decrease of PPARδexpression. Thus, change of PPARδexpression with the progress of diabetes seems responsible for the higher mortality rate after SCI.
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Cassis, L. A. "Downregulation of the renin-angiotensin system in streptozotocin-diabetic rats." American Journal of Physiology-Endocrinology and Metabolism 262, no. 1 (January 1, 1992): E105—E109. http://dx.doi.org/10.1152/ajpendo.1992.262.1.e105.

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To determine if insulin has the ability to regulate components of the renin-angiotensin system, renin and angiotensinogen mRNA and plasma concentrations were determined in 4-wk streptozotocin (STZ)-diabetic rats. In another group of STZ-diabetic rats, replacement insulin therapy was given over the 4-wk period, and the above parameters were examined. In STZ-diabetic rats, there was a significant regression of white adipose tissue that was accompanied by an increase in the yield of RNA obtained. Changes in white adipose tissue were reversed by insulin replacement therapy in STZ-diabetic rats. There were no changes in brown adipose tissue weight or RNA yield in STZ-diabetic rats. Plasma renin activity (PRA) was significantly decreased in STZ-diabetic rats; however, plasma angiotensinogen concentration was not significantly affected by diabetes. PRA was restored to control levels in STZ-diabetic rats with insulin replacement. Kidney renin mRNA as well as liver, epididymal, and interscapular fat angiotensinogen mRNA were significantly decreased in STZ-diabetic rats. Renin and angiotensinogen mRNA were not significantly different from control in all tissues examined in STZ-diabetic rats with insulin replacement therapy. Results from this study suggest a downregulation of the renin-angiotensin system in 4-wk STZ-diabetic rats at the level of mRNA expression that is restored by replacement therapy with insulin; therefore, insulin may directly or indirectly regulate the renin-angiotensin system.
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Yamamoto, Tetsushi, Hiroko Otake, Noriko Hiramatsu, Naoki Yamamoto, Atsushi Taga, and Noriaki Nagai. "A Proteomic Approach for Understanding the Mechanisms of Delayed Corneal Wound Healing in Diabetic Keratopathy Using Diabetic Model Rat." International Journal of Molecular Sciences 19, no. 11 (November 18, 2018): 3635. http://dx.doi.org/10.3390/ijms19113635.

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Diabetes mellitus is a widespread metabolic disorder, and long-term hyperglycemia in diabetics leads to diabetic keratopathy. In the present study, we used a shotgun liquid chromatography/mass spectrometry-based global proteomic approach using the cornea of streptozotocin-induced diabetic (STZ) rats to examine the mechanisms of delayed corneal wound healing in diabetic keratopathy. Applying a label-free quantitation method based on spectral counting, we identified 188 proteins that showed expression changes of >2.0-fold in the cornea of STZ rats. In particular, the level of lumican expression in the cornea of STZ rats was higher than that of the normal rats. In the cornea of the normal rat, the expression level of lumican was elevated during the wound healing process, and it returned to the same expression level as before cornea injury after the wound was healed completely. On the other hand, a high expression level of lumican in the cornea of STZ rats was still maintained even after the wound was healed completely. In addition, adhesion deficiency in corneal basal cells and Bowman’s membrane was observed in the STZ rat. Thus, abnormally overexpressed lumican may lead to adhesion deficiency in the cornea of STZ rats.
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Martínez, Isabel M., Inmaculada Morales, Guadalupe García-Pino, José E. Campillo, and María A. Tormo. "Experimental Type 2 Diabetes Induces Enzymatic Changes in Isolated Rat Enterocytes." Experimental Diabesity Research 4, no. 2 (2003): 119–23. http://dx.doi.org/10.1155/edr.2003.119.

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Diabetes in humans and in experimental animals produces changes in the function and structure of the small intestine. The authors determined the activity of intestinal disaccharidases (maltase and sucrase) and of 6-phosphofructo-1-kinase (PFK-1) in enterocytes isolated from the small intestine of male Wistar rats (2.5 to 3 months old) with experimental nonobese type 2 diabetes, induced by streptozotocin (STZ) injection on the day of birth (n0-STZ) or on the 5th day of life (n5-STZ), with different degrees of hyperglycemia and insulinemia (n0-STZ and n5-STZ models). The glycemia (mmol/L) of the diabetic rats (n0-STZ: 8.77 ± 0.47; n5-STZ: 20.83 ± 0.63) was higher (P< .01) than that of the nondiabetic (ND) rats (5.99 ± 0.63); on the contrary, the insulinemia (ng/mL) was significantly lower in both n0-STZ (1.74 ± 0.53;P< .05) and n5-STZ (1.12 ± 0.44;P< .01) diabetic rats than in normal rats (3.77 ± 0.22). The sucrase and maltase activities (U/g protein) in diabetic rats (n0-STZ: 89 ± 9 and 266 ± 12; n5-STZ: 142 ± 23 and 451 ± 57) were significantly higher than those in the ND group (66 ± 5 and 228 ± 22). The PFK-1 activities (mU/mg protein) in the diabetic models (n0-STZ: 14.89 ± 1.51; n5-STZ: 13.35 ± 3.12) were significantly lower (P< .05) than in ND rats (20.54 ± 2.83). The data demonstrated enzymatic alterations in enterocytes isolated fromthe small intestine of n0-STZ rats that are greater (P< .05) than in the more hyperglycemic and hypoinsulinemic n5-STZ animals. The results also show that nonobese type 2–like diabetes in the rat produces modifications that favor an increase in glucose absorption rates.
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El Barky, Amira Ragab, Samy A. Hussein, Abeer A. Alm-Eldeen, yehia A. Hafez, and Tarek M. Mohammed. "Saponin ameliorate diabetes in STZ-diabetic rats." Delta Journal of Science 38, no. 2 (December 1, 2017): 177–82. http://dx.doi.org/10.21608/djs.2017.139442.

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ElBatsh, Maha Mohamed. "Antidepressant-like effect of simvastatin in diabetic rats." Canadian Journal of Physiology and Pharmacology 93, no. 8 (August 2015): 649–56. http://dx.doi.org/10.1139/cjpp-2014-0560.

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Diabetes mellitus is accompanied by hormonal and neurochemical changes that can be associated with anxiety and depression. I investigated the antidepressant effect of simvastatin (SMV) on diabetic rats. Rats were divided into control (CTR) and streptozotocin-induced diabetic (STZ) groups and were orally administered 0, 5, or 10 mg/kg of SMV daily for 14 days, then exposed to the forced swimming test (FST). Our results showed that diabetic rats had higher immobility duration than the CTR rats, and SMV decreased this depressive-like behavior in the diabetic rats. However, clomipramine lowered the immobility time in the CTR and STZ rats. STZ decreased serotonin concentration in the hippocampus, which was reversed by SMV and clomipramine. The dopamine concentration in the hippocampus decreased in the STZ groups compared with the CTR groups. However, SMV and clomipramine had no significant effect on the dopamine levels in either the CTR or STZ groups. Corticosterone levels were increased in the untreated STZ group; SMV and clomipramine significantly decreased corticosterone levels in the STZ groups, but had no effect on the CTR groups. In conclusion, SMV exerts an antidepressant-like effect on diabetic rats that are submitted to the FST. The antidepressant-like effect of SMV in the FST appears to be mediated, at least in part, by the biochemical changes to the blood levels of corticosterone and of serotonin concentration in the hippocampus.
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Dissertations / Theses on the topic "STZ diabetic rats"

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Thompson, Katherine Hirsch. "Effect of dietary manganese and vitamin E deficiencies on tissue antioxidant status in STZ-diabetic rats." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/32171.

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Interactions between manganese (Mn) deficiency and streptozotocin (STZ)-diabetes with respect to tissue antioxidant status were investigated in male, Sprague-Dawley rats. All rats were fed either a Mn-deficient (1 ppm) or a Mn-sufficient (45 ppm) diet for 8 weeks. Diabetes was then induced by tail-vein injection of STZ (60 mg/kg body weight), after which the rats were kept for an additional 4 to 8 weeks. The control groups comprised rats not injected with STZ, which were either Mn-deficient or Mn-sufficient. The Mn-deficient diet decreased the activities of manganese superoxide dismutase (MnSOD) in kidney and heart, and of copper-zinc superoxide dismutase (CuZnSOD) in kidney, in non-diabetic animals. In the diabetic rats, the Mn-deficient diet induced more pronounced decreases in activities of these same enzymes, and also increased liver MnSOD activity. Pancreas weights were significantly lower in Mn-deficient, compared to Mn-sufficient rats. Also, Mn-deficient, diabetic rats were significantly more hyperglycemic in response to a glucose load than Mn-sufficient, suggesting that they may have been more severely diabetic. Surprisingly, plasma and hepatic vitamin E levels increased progressively with the duration of diabetes. Lipid peroxidation, as measured by H₂O₂ -induced production of thiobarbituric acid reactive substances in erythrocytes, plasma lipoperoxides, and renal adipose tissue fluorescence, also increased concomitant with decreased liver and kidney glutathione levels. The effect of vitamin E-deficiency on Mn-deficient, diabetic rats was also investigated. Predictably, vitamin E-deficient rats were almost entirely depleted of plasma and liver vitamin E after 12 weeks on the deficient diets (4 weeks after STZ treatment). Consistent with this, tissue lipid peroxides were elevated compared to vitamin E-sufficient rats. Superimposing vitamin E-deficiency on manganese deficiency failed to add any further deficits in tissue antioxidant status. Higher glycosylated hemoglobin levels were observed in vitamin E-deficient, compared to vitamin E-sufficient, diabetic rats. These findings demonstrate for the first time an interactive effect between manganese deficiency and STZ-diabetes resulting in amplification of tissue antioxidant changes seen with either manganese deficiency or STZ-diabetes alone. This effect of cofactor deprivation in experimental diabetes raises the question of adequacy of the nominally Mn-sufficient diet in insulin-dependent diabetes mellitus.
Land and Food Systems, Faculty of
Graduate
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Fullarton, Agneta Carol. "An investigation into the recovery of function after different types of injury and repair of peripheral nerve : a comparison between non-diabetic and STZ diabetic rats." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20514.

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Xiang, Hong. "Effects of myo-inositol and, or triiodothyronine (T₃) treatment on cardiac dysfunction and elevated myocardial lipid levels in STZ-diabetic rats." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26675.

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A number of experimental studies have implied a link between diabetes-induced lipid accumulation in the myocardium and the development of cardiomyopathy. Since diabetics excrete large amounts of myo-inositol which is a lipotropic agent, this study was undertaken to investigate the effects of myo-inositol on the elevated myocardial lipid levels and the depressed cardiac performance of diabetic rats. Diabetes was induced in female Wistar rats (190-215 g) with streptozotocin (STZ) (55 mg/kg, i.v.). Three days after diabetes induction, myo-inositol was administered in the drinking water (2.5 g/kg/day) for a 8 week period. Untreated diabetics exhibited a loss of body weight, hyperglycemia, hypoinsulinemia and hypothyroidism. These effects were not altered after myo-inositol treatment. STZ-diabetes also produced a significant elevation of plasma and myocardial triacylglycerol, cholesterol and phospholipid. Myo-inositol treatment decreased these lipid levels. In addition, hearts from diabetic animals had a decreased ability to develop left ventricular developed pressure (LVDP) and both the rate of pressure rise (+dP/dt) and the rate of pressure decline (-dP/dt) were also reduced. Hearts from myo-inositol-treated diabetic animals showed a partial but definite improvement of cardiac function. As diabetes-induced hypothyroidism was not altered after myo-inositol supplementation, a combination treatment of both myo-inositol (2.5 g/kg/day, p.o. daily) and T₃ (30 ug/kg/day, s.c. daily) was then undertaken to determine whether heart function of diabetic rats could be further improved. STZ-diabetic rats were characterized by a loss of body weight, hyperglycemia and hypoinsulinemia; none of which were altered by either T₃ or myo-inositol plusT₃ treatment. T₃ treatment normalized the thyroid state of diabetic animals as shown by Tahiliani and McNeill (1984). However, plasma and myocardial triacylglycerol, cholesterol and phospholipid levels of diabetic rats either remained elevated or were further increased with T₃ or myo-inositol plus T₃ treatment. In addition, T₃ treatment alone did not prevent cardiac dysfunction in diabetic rats. There was, however, some improvement in heart function in the groups treated with both myo-inositol and T₃, but the improvement was not as pronounced as with myo-inositol treatment alone.
Pharmaceutical Sciences, Faculty of
Graduate
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Lemos, Virgínia Carvalho. "Evaluation of the effect of A. unedo L. extracts on blood indices and microelements status in high-fat STZ-induced diabetic rats." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15469.

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Mestrado em Bioquímica - Métodos Biomoléculares
The strawberry tree (Arbutus unedo L.) is an endemic shrub, which grows in the Mediterranean region. In Portugal, it can be found through all the country but mostly in the south. The fruit is used to produce hams and jellies and firewater, reason why the fruit’s chemical composition is relatively well known, when compared to the leaves. Until now, there are only a few studies concerning the leaves’ chemical composition and the existing mainly focus on their phenolic content. This plant has long been used in folk medicine to treat a vast amount of illnesses like gastrointestinal disorders, gastritis, dermatologic and urological problems, kidney problems and cardiovascular diseases. However, very few studies in vivo have been performed about these medicinal properties until now. Diabetes is a pandemic disease that affects millions of people. There are only two studies about A. unedo root’s aqueous extract antidiabetic properties. This study evaluated the anti-diabetic effect of strawberry tree (Arbutus unedo L.) fruit and leaf aqueous extracts in streptozotocin (STZ) induced diabetic rats fed with a high-fat diet. Firstly the optimal parameters to obtain the fruit aqueous extract were established. After that, the leaves and fruits aqueous extracts were characterized in terms of total phenolic content (TPC). Leaf aqueous extracts presented a higher TPC concentration than the fruit aqueous extract. Male Wistar rats were injected with STZ, after a 2 week feeding with high-fat diet in order to induce non-insulin dependent type 2 diabetes. After confirmation of the rats’ diabetic state, the animals were fed with Arbutus unedo L. fruit aqueous extract or leaf aqueous extract added to the high-fat diet for 4 weeks. The extracts were given in the following doses: 1.25g /kg b.w./day for leaf extract and 0.5g /kg b.w./day for fruit extract. After the animals were sacrificed analyses were perform for blood indices, haematological indices, mineral tissular status and gene expression. Arbutus unedo L. fruit extract presented a tendency to lower blood glucose levels. More beneficial effects were seen for this extract in terms of regulating TNF-α gene expression in muscular tissue. Some effects in zinc renal homeostasis were also shown, although they were not very significant. The leaf extract, appeared to be more efficient in regulating insulin levels and improving HOMA-IR index. It also presented a tendency towards lowering blood glucose levels. Both extracts proved to efficiently improve insulin sensitivity (leaf extract in a larger extent). In this study, there were also some good preliminary results, as the groups supplemented with this extracts showed a tendency in decreasing serum creatinine and/or phosphatase concentration, improving the Red Cell Distribution Width measured with standard deviation (RDW-SD) and lymphocytes concentration. Positive antidiabetic and anti-inflammatory aspects were found for both aqueous extracts. The results obtained confirm the mid-therapeutically effects of A. unedo as the plant’s material effectively improved insulin sensitivity (HOMA-IR index) although failed to significantly modulate glucose metabolism. This study was the first in vivo trial on a type 2 diabetes animal model that evaluated the antidiabetic potential of Arbutus unedo L. fruits and leaves aqueous extracts.
O medronheiro (Arbutus unedo L.) é um arbusto endémico que cresce em toda a região Mediterrânica. Em Portugal, pode ser encontrado em todo o território continental, principalmente na zona sul do país. O fruto é utilizado na produção de compotas, marmeladas e aguardente, pelo que a composição química deste é relativamente bem conhecido quando comparado com as folhas. Actualmente, existem poucos estudos sobre a composição química das folhas, sendo que a maioria visa apenas o seu conteúdo em compostos fenólicos. Esta planta tem sido utilizada na medicina popular para tratar diversas doenças tais como distúrbios gastrointestinais, gastrite, problemas dermatológico, urológicos, renais e cardiovasculares. No entanto, até ao momento existem poucos estudos in vivo que atestem estas propriedades medicinais, o que justifica a realização deste tipo de ensaios. No caso da diabetes, que afecta milhões de pessoas em todo o mundo, existem apenas dois estudos sobre as propriedades antidiabéticas do extrato aquoso das raízes de A. unedo. O presente trabalho de mestrado avaliou o potencial antidiabético dos extractos aquosos das folhas e frutos do medronheiro. O estudo foi efectuado em ratos diabéticos (diabetes induzida por Estreptozotocina - STZ) alimentados com uma ração rica em gordura. Primeiramente foram optimizados os parâmetros de extracção para a obtenção do extrato aquosos do fruto. De seguida os extratos aquosos de folhas e frutos foram caracterizados em termos de teor em fenóis totais. O extrato aquoso das folhas apresentou uma maior concentração de fenóis totais do que o extrato aquoso do fruto. Ratos Wistar do sexo masculino foram injectados com STZ após serem alimentados durante 2 semanas com uma dieta rica em gordura. Desta forma induziu-se diabetes tipo 2, não dependente de insulina. Após a confirmação da condição diabética dos ratos, a dieta rica em gordura continuou a ser administrada aos animais. No entanto, as dietas foram suplementadas com extrato aquoso ou do fruto ou das folhas de Arbutus unedo L., num tratamento com a duração de 4 semanas. Os extratos foram administrados nas seguintes doses: 1.25g /kg peso corporal/dia no caso do extrato da folhas 0.5g /kg peso corporal/dia no caso do extrato do fruto. Efectuaram-se análises a parâmetros do sangue, hematológicos, à homeostasia mineral dos tecidos e à expressão de determinados genes após os animais serem sacrificados. O extrato do fruto apresentou uma tendência a regular os níveis de glucose no sangue. Outros efeitos benéficos foram atribuídos a este extrato, nomeadamente ao nível da regulação da expressão do gene de TNF-α a nível muscular. Este extrato também apresentou alguns efeitos ao nível da regulação da homeostase renal de zinco, embora não muito significativos. O extrato da folha provou ser mais eficiente a regular os níveis de insulina, a melhorar a resistência à insulina (HOMA-IR). Também apresentou uma tendência a regular os níveis de glucose no sangue. Ambos os extratos aumentaram de forma eficiente a sensibilidade à insulina (embora o extrato da folha o tenha feito de forma mais pronunciada). Obtiveram-se ainda bons resultados preliminares, uma vez que estes extratos demostraram que ocorreu uma tendência em termos de diminuição da concentração de creatinina e/ou fosfatase, de aumento do valor do parâmetro de Amplitude de Distribuição dos Eritrócitos medido como Desvio Padrão (RDW-SD), de aumento da concentração de linfócitos e diminuíram. Para ambos os extratos foram detectados efeitos antidiabéticos e anti-inflamatórios. Os resultados obtidos confirmam que A. unedo apresenta alguns efeitos terapêuticos, embora ligeiros. Os extratos desta planta melhoraram significativamente a sensibilidade à insulina mas não conseguiram regular significativamente o metabolismo da glucose. Este estudo foi o primeiro, num modelo animal de diabetes tipo 2 que avaliou o potencial antidiabético dos extratos aquosos dos frutos e folhas de Arbutus unedo L.
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Cameron-Smith, David, and edu au jillj@deakin edu au mikewood@deakin edu au wildol@deakin edu au kimg@deakin. "THE INTERACTION OF DIETARY FIBRE, CARBOHYDRATE METABOLISM AND DIABETES IN THE RAT." Deakin University. School of Health and Behavioral Sciences, 1994. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20040622.171657.

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It is currently accepted that the most appropriate diet in the treatment of non-insulin-dependent diabetes mellitus "eNIDDM"e is high in carbohydrates, high in fibre and low in fat. Dietary fibre reduces the rate of carbohydrate absorption, which may have a beneficial effect on insulin action. Furthermore, high fibre diets also increase the amount of carbohydrates which are not absorbed from the small intestine. These malabsorbed carbohydrates are fermented by the bacterial population in the large intestine, producing short chain fatty acids "eSCFA"e, including propionate, which has been shown to alter liver carbohydrate metabolism. This thesis investigated the actions of slowed carbohydrate absorption and carbohydrate malabsorption in streptozotocin-induced "eSTZ"e diabetic rats. High carbohydrate diet supplemented with guar gum, a soluble dietary fibre, fed to STZ diabetic rats improved insulin sensitivity. investigation of the alterations in the stomach and small intestine demonstrated that guar increased the viscosity of the meal in the intestine. The action of increased fermentation, producing more propionate, was investigated by supplementing propionate into the diets of STZ diabetic rats or when perfused into isolated rat livers. No changes in insulin action or liver glucose metabolism were measured. in addition, it was shown that guar gum reduces food intake in STZ diabetic rats. Mild reductions in food intake in STZ diabetic rats were shown to increase insulin action. In summary, STZ diabetic rats fed high carbohydrate, high fibre diets reductions in food consumption and slowed carbohydrate absorption are important factors which may lower blood glucose concentrations and increase insulin action. increased SCFA production is unlikely to contribute significantly to the improvements in insulin action.
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Sinzato, Yuri Karen. "Análise morfológica e imunológica das placentas de ratas com diabete de intensidade moderada /." Botucatu, 2009. http://hdl.handle.net/11449/106385.

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Orientador: Débora Cristina Damasceno
Banca: Marilza Vieira Cunha Rudge
Banca: Estela Maris Andrade Forell Bevillacqua
Banca: Renée Laufer Amorim
Banca: Teresa Cristina França Sartori
Resumo: Avaliar os efeitos do diabete moderado nos parâmetros reprodutivos maternos e no desenvolvimento placentário-fetal em ratas Wistar. Metodologia: No dia do nascimento, 147 ratas Wistar foram distribuídas aleatoriamente em dois grupos experimentais: Grupo não-diabético (Controle, n=45) - recebeu o veículo; Grupo diabético (STZ, n=102) - recebeu 100 mg streptozotocin/kg. Na fase adulta, as ratas foram acasaladas e, no dia 0 de prenhez, foram incluídas ratas controle que apresentassem glicemia abaixo de 120 mg/dL e, para o grupo diabete moderado, glicemia entre 120 e 300 mg/dL. Em diferentes momentos da prenhez, glicemia e peso corpóreo foram verificados. No 21º dia de prenhez, as ratas foram anestesiadas para coleta de sangue para dosagem de insulina e, em seguida, foi realizada laparotomia para retirada e pesagem dos fetos e placentas. Os dados maternos e fetais foram analisados por Twoway ANOVA seguida do Teste t. Os recém-nascidos (RN) foram classificados em pequenos, adequados e grandes para idade de prenhez e as comparações entre os grupos foram realizadas segundo o Teste de Qui-quadrado. As ratas STZ apresentaram glicemias maiores nos dias 0 e 14 de prenhez, menor número médio de fetos vivos, implantações e de corpos lúteos, aumento nas taxas de perdas embrionárias pós-implantação, no peso placentário e na proporção de RN pequenos (PIP) e grandes (GIP) para idade de prenhez, redução de RN AIP e inalteração nas concentrações de insulina. Portanto, o diabete de intensidade moderada alterou a glicemia materna no início da prenhez, que deflagrou alterações no organismo materno e/ou no desenvolvimento inicial do embrião, afetando sua implantação e futuro desenvolvimento placentário e fetal.
Abstract: To evaluate the mild diabetes effects on the maternal reproductive outcome and placental-fetal development in female Wistar rats. Methodology: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) - received 100 mg streptozotocin/kg. At the adult phase, the female rats were mated and, at the day 0 of pregnancy, they were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ when showed glycemia between 120 and 300 mg/dL. In different moments of the pregnancy, glycemia and body weight were verified. At day 21 of pregnancy, the rats were anaesthetized to collect blood samples for insulin determination and, soon afterwards, the laparotomy was carried out to withdraw and weigh the fetuses and placentas. The maternal and fetal dates were analyzed by Two-way ANOVA followed by t Test. The newborns (NB) were classified in small, appropriate and large for gestational age and the comparisons between the groups were accomplished according to Qui-square Test. Rats STZ presented higher glycemia at days 0 and 14 of pregnancy, lower numbers of alive fetuses; implantations and corpora lutea; increased rate of embryonic losses, placental weight and proportion of small NB (SGA) and large (LGA); reduced rate of AGA NB and unaltered insulin concentrations. Therefore, the mild diabetes altered the maternal glycemia in the early pregnancy, which caused changes in the maternal organism and/or in the early development of the embryo, impairing its implantation and future placental and fetal development.
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7

Sinzato, Yuri Karen [UNESP]. "Análise morfológica e imunológica das placentas de ratas com diabete de intensidade moderada." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/106385.

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Made available in DSpace on 2014-06-11T19:35:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-27Bitstream added on 2014-06-13T18:47:00Z : No. of bitstreams: 1 sinzato_yk_dr_botfm.pdf: 273220 bytes, checksum: 7f61ff6bd8aff6dcd2d1543cbfa1ca95 (MD5)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Avaliar os efeitos do diabete moderado nos parâmetros reprodutivos maternos e no desenvolvimento placentário-fetal em ratas Wistar. Metodologia: No dia do nascimento, 147 ratas Wistar foram distribuídas aleatoriamente em dois grupos experimentais: Grupo não-diabético (Controle, n=45) - recebeu o veículo; Grupo diabético (STZ, n=102) - recebeu 100 mg streptozotocin/kg. Na fase adulta, as ratas foram acasaladas e, no dia 0 de prenhez, foram incluídas ratas controle que apresentassem glicemia abaixo de 120 mg/dL e, para o grupo diabete moderado, glicemia entre 120 e 300 mg/dL. Em diferentes momentos da prenhez, glicemia e peso corpóreo foram verificados. No 21º dia de prenhez, as ratas foram anestesiadas para coleta de sangue para dosagem de insulina e, em seguida, foi realizada laparotomia para retirada e pesagem dos fetos e placentas. Os dados maternos e fetais foram analisados por Twoway ANOVA seguida do Teste t. Os recém-nascidos (RN) foram classificados em pequenos, adequados e grandes para idade de prenhez e as comparações entre os grupos foram realizadas segundo o Teste de Qui-quadrado. As ratas STZ apresentaram glicemias maiores nos dias 0 e 14 de prenhez, menor número médio de fetos vivos, implantações e de corpos lúteos, aumento nas taxas de perdas embrionárias pós-implantação, no peso placentário e na proporção de RN pequenos (PIP) e grandes (GIP) para idade de prenhez, redução de RN AIP e inalteração nas concentrações de insulina. Portanto, o diabete de intensidade moderada alterou a glicemia materna no início da prenhez, que deflagrou alterações no organismo materno e/ou no desenvolvimento inicial do embrião, afetando sua implantação e futuro desenvolvimento placentário e fetal.
To evaluate the mild diabetes effects on the maternal reproductive outcome and placental-fetal development in female Wistar rats. Methodology: At the birth day, 147 female rats were randomly distributed in two experimental groups: 1) Non-diabetic Group (Control, n=45) - received the vehicle; 2) Diabetic Group (STZ, n=102) - received 100 mg streptozotocin/kg. At the adult phase, the female rats were mated and, at the day 0 of pregnancy, they were included in the control group when presented glycemia below 120 mg/dL and, in the group STZ when showed glycemia between 120 and 300 mg/dL. In different moments of the pregnancy, glycemia and body weight were verified. At day 21 of pregnancy, the rats were anaesthetized to collect blood samples for insulin determination and, soon afterwards, the laparotomy was carried out to withdraw and weigh the fetuses and placentas. The maternal and fetal dates were analyzed by Two-way ANOVA followed by t Test. The newborns (NB) were classified in small, appropriate and large for gestational age and the comparisons between the groups were accomplished according to Qui-square Test. Rats STZ presented higher glycemia at days 0 and 14 of pregnancy, lower numbers of alive fetuses; implantations and corpora lutea; increased rate of embryonic losses, placental weight and proportion of small NB (SGA) and large (LGA); reduced rate of AGA NB and unaltered insulin concentrations. Therefore, the mild diabetes altered the maternal glycemia in the early pregnancy, which caused changes in the maternal organism and/or in the early development of the embryo, impairing its implantation and future placental and fetal development.
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8

Yi-Hui and 顏翊橞. "Anti-diabetic effects of mulberry leaf extract on STZ-induced diabetic rats." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/r768x3.

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碩士
中山醫學大學
營養學研究所
100
Diabetes Melitus (DM) is one of the most popular chronic diseases in the world. Poor glycemic control is a known major factor that leads to diabetic complications and is attributed to increased oxidative stress. According to previous studies, Morus alba leaves and its extract (ME) possesses hypoglycemic effect with 1-deoxynojirimycin (1-DNJ) as a functional compound. However, the mechanisms underlying which ME and 1-DNJ lowering blood glucose level remain to be clarified. It is also not known how ME and 1-DNJ affect the development of DM nephropathy. The aim of this study is to investigate the antidiabetic effect of ME and 1-DNJ including their effect on the development of diabetic nephropathy and the related mechanisms. Male Wistar rats were injected with streptozotocin (65 mg/kg BW, i.v.) to induce DM. Control rats were injected with citrate buffer solution. 7 days after induction, the DM rats were assigned randomly to six groups and were treated with 1, 3, 10, 30 mg/kg BW of ME, 30 mg/kg BW of DNJ or vehicle (d.d. H2O; 2 ml/kg BW) for a week. Normal control rats also received vehicle. OGTT was carried out at 7 or 11 days and ITT was carried out at 11 days after induction. At 14 days after induction, rats were killed with CO2 and organ/tissue samples collected for various biochemical analyses and the determination of oxidative stress and renal function. On the DM rats all doses of ME and 1-DNJ significantly ameliorated fasting blood glucose and AUC of glucose during OGTT period chronically and ME also showed such effect acutely. All doses of ME and 1-DNJ significantly increased peripheral and pancreatic levels of insulin and improved HOMA-IR in DM rats. Ten and 30 mg/kg of ME improved insulin-induced lowering of blood glucose level in DM rats. In the other hand, all doses of ME and 1-DNJ significantly reversed increased TBARS of the pancreas, kidneys, livers, muscles and peripheral blood in DM as well as decreased GRd activity of the pancreas and kidneys in DM. In addition, 1-DNJ significantly reversed lowered GPx and GRd activity of the livers and muscles in DM. ME at 30 mg/kg significantly reversed lowered GPx activity of the muscle, at 10 to 30 mg/kg significantly reversed lowered GRd activity of the kidneys, at 1 mg/kg significantly reversed lowered GRd activity of of the livers, at 3 to 30 mg/kg significantly reversed lowered GRd activity of the muscles. All ME doses and 1-DNJ significantly decreased NO content of the pancreas, kidneys, livers,and muscles in DM. The indices of renal function, including BUN, CCR, and GFR were all ameliorated by all doses of ME and 1-DNJ. In addition, 30 mg/kg of ME and 1-DNJ improved glomerular morphology of the kidneys and lowered blood pressure in DM. In conclusion, ME and 1-DNJ improved insulin secretion and insulin sensitivity and attenuated the development of diabetic nephropathy. The antidiabetic effects of ME and 1-DNJ is at least partly due to the amelioration of the increased oxidative stress in DM.
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9

Yao, Jun. "Effects of vanadium compounds on diabetes induced changes in STZ-diabetic rats." Thesis, 1996. http://hdl.handle.net/2429/4473.

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Controversial reports on the efficacy and possible toxicity of vanadium obtained from various studies may be attributed to differences in the method of diabetes induction and/or to differences in animal strains. The objective of this study was to evaluate the contribution of these two factors to the effects of vanadium in the treatment of diabetes. Two methods of streptozotocin (STZ) induced diabetes in rats have been used for studying the antidiabetic effects of vanadium. One involves a single intravenous (i.v.) injection of 60 mg/kg STZ, and the other uses two subcutaneous (s.c.) injections of 40 mg/kg STZ, to either Wistar or Sprague Dawley (SD) rats. In a 7-week chronic study, SD rats appeared to develop a more severe diabetes (indicated by higher plasma cholesterol and higher fasting plasma glucose levels) following the single i.v. injection of STZ than rats made diabetic by two s.c. injections of STZ. Irrespective of the method of diabetes induction or the strain of rat, the responses of all the diabetic animals to vanadyl sulphate treatment were similar. In a 1-week acute study, Wistar diabetic rats were more responsive than SD diabetic rats to vanadyl sulphate and to lower doses (0.6 and 0.8 mmol/kg) of a new organic compound, bis(maltolato)oxovanadium(IV).
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10

Chen, Tai-You, and 陳泰佑. "Effects of Cordyceps sinensis on Blood Glucose in STZ-induced Diabetic Rats." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/89246554680918450648.

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碩士
國立中興大學
獸醫學系暨研究所
101
In recent years, researches indicate diabetes implicated in metabolic syndrome. There are sulfonylurea, bioguanides, alpha-glucosidase inhibitor, thiazolidinediones, insulin, dipeptidyl peptidase-4 inhibitors and so on in diabetic drugs which have their indication and a lot of side effects. Therefore, many researchers develop drugs or extraction for natural products to improve metabolic syndrome and control diabetes, and moreover can reach prevention. Cordyceps has a large amount of biological ingredients which increase numbers of transporter proteins and stablelize concentration of blood glucose. Therefore, we found Cordyceps extract could prevent hyperglycemia in STZ-induced diabetic rats.
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Books on the topic "STZ diabetic rats"

1

Akirav, Eitan Moshe. Leptin restoration in streptozotocin (STZ)-diabetic rats. Ottawa: National Library of Canada, 2002.

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Montes, Danitza Eustolia Goche. Effects of restraint stress on hypothalamic-pituitary-adrenal activity in STZ-diabetic rats. 2005.

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Book chapters on the topic "STZ diabetic rats"

1

Shintaku, H., M. Imanishi, M. Okumura, S. Fujii, E. Kawai, S. Genba, K. Takahashi, Y. Sawada, and T. Yamano. "The Effect of Tetrahydrobiopterin (BH4) on Diabetic Nephropathy in Streptozotocin (STZ) Induced Diabetic Rats." In Chemistry and Biology of Pteridines and Folates, 355–58. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0945-5_59.

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Karuppannan, P., K. Saravanan, and P. Premalatha. "Antidiabetic Activity of Ventilago maderaspatana Leaf Extracts on STZ Induced Diabetic Rats." In Drug Development for Cancer and Diabetes, 283–92. Includes bibliographical references and index.: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429330490-24.

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Elavarasi, S., G. Revathi, K. Saravanan, and Horne Iona Averal. "Antidiabetic and Antihyperlipidemic Activities of Cyathea nilgiriensis (Holttum) on STZ Induced Diabetic Rats." In Drug Development for Cancer and Diabetes, 233–48. Includes bibliographical references and index.: Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780429330490-20.

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Jaffar, S. K., S. M. Khasim, and M. S. K. Prasad. "Protective Effect of Mimusops elengi L. on Renal and Hepatic Markers in STZ-Induced Diabetic Rats." In Medicinal Plants: Biodiversity, Sustainable Utilization and Conservation, 509–20. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1636-8_28.

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Valdivielso, José M., Angel Montero, Karen A. Munger, and Kamal F. Badr. "Inhibition of 5-lo Activating Protein (Flap) Activity Decreases Proteinuria in Streptozotocin(Stz)-induced Diabetic Rats." In Advances in Experimental Medicine and Biology, 79–83. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0193-0_13.

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Poucheret, Patrick, René Gross, Anne Cadène, Michelle Mantéguetti, Jean-Jacques Serrano, Gérard Ribes, and Gérard Cros. "Long-term correction of STZ-diabetic rats after short-term i.p. VOSO4 treatment: Persistence of insulin secreting capacities assessed by isolated pancreas studies." In Vanadium Compounds: Biochemical and Therapeutic Applications, 197–204. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4613-1251-2_26.

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Jasmine, R., and A. Sherlin Rosita. "Regeneration of Beta Cells by Inhibition of pro-Apoptotic Proteins through Phytocompound in STZ Induced Diabetic Albino Wistar Rats: In Vivo and In Silico Approach." In Structure and Health Effects of Natural Products on Diabetes Mellitus, 219–34. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8791-7_12.

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Umrani, Dhananjay N., Dipali N. Bodiwala, and Ramesh K. Goyal. "Effect of sarpogrelate on altered STZ-diabetes induced cardiovascular responses to 5-hydroxytryptamine in rats." In Biochemistry of Diabetes and Atherosclerosis, 53–57. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9236-9_7.

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Serradas, P., M. Dolz, M. Giroix, D. Bailbe, C. Cuzin-Tourrel, M. Kergoat, B. Portha, and J. Movassat. "Neonatally Streptozotocin- Induced (n-STZ) Diabetic Rats." In Animal Models of Diabetes, Second Edition, 223–50. CRC Press, 2007. http://dx.doi.org/10.1201/9781420009453.ch10.

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Jatziry Hernández-Esparza, Manjury, Claudia Guadalupe Flores-Ledesma, Rocío Montoya-Pérez, Elizabeth Calderón-Cortés, Alfredo Saavedra-Molina, Alain Raimundo Rodríguez-Orozco, and Christian Cortés-Rojo. "Thiol Reduction and Cardiolipin Improve Complex I Activity and Free Radical Production in Liver Mitochondria of Streptozotocin-Induced Diabetic Rats." In Antioxidants [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.95112.

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Mitochondrial reactive oxygen species (ROS) are involved in diabetic liver disease development. Diabetes impairs complex I activity and increases ROS production in liver mitochondria. The complex I produces ROS in forward electron transfer (FET) or in reverse electron transfer (RET) modes depending on the site of electron transfer blocking and the availability of respiratory substrates. Complex I activity depends on the phospholipid cardiolipin and the redox state of reactive thiols in the enzyme. Neither the underlying factors leading to complex I dysfunction nor the mode of ROS production have been elucidated in liver mitochondria in diabetes. We tested in liver mitochondria from streptozotocin (STZ) -induced diabetic rats if the addition of cardiolipin or β-mercaptoethanol, a thiol reducing agent, recovers complex I activity and decreases ROS production with substrates inducing ROS production in FET or RET modes. Decreased complex I activity and enhanced ROS generation in FET mode was detected in mitochondria from diabetic rats. Complex I activity was fully restored with the combined treatment with cardiolipin plus β-mercaptoethanol, which also abated ROS generation in FET mode. This suggest that therapies restoring cardiolipin and reducing mitochondrial thiols might be useful to counteract impaired complex I activity and excessive ROS production in liver mitochondria in diabetes.
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Conference papers on the topic "STZ diabetic rats"

1

Öztürk, Melek. "Dipeptidyl peptidase-4 inhibition causes liver regeneration in neonatal STZ-diabetic rats." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-75.

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Sarkodie, J., C. Asare, P. Debrah, and E. Oppong Bekoe. "Taraxacum officinale leaves aqueous extract-mediated glucose lowering effect in STZ-induced diabetic rats." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608450.

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Tunçdemi̇r, Matem. "Investigation of the quercetin effect on apoptosis in diabetic nephropathy model rats induced by STZ." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-20.

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Kaya Dagistanli, Fatma. "The role of aging and ER stress related proteins on testicular disturbances in STZ-diabetic rats." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-275.

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Puspawati, Gusti, Yustinus Marsono, and Supriyadi. "Decreasing of Oxidative Stress of Red Tamarillo (Solanum Betaceum Cav.) Extract in STZ-NA-Induced Diabetic Rats." In ASEAN Food Conference. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0010016601730180.

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Islamiana, Dini, Intan Susmita Rafsanjani, Miranti Dewi Pramaningtyas, and Ana Fauziyati. "Effect of High-Fat Diet on Systolic Blood Pressure in STZ-Induced Diabetic Adolescent Sprague Dawley Rats." In 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/ahsr.k.210115.014.

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Amâncio, Lívia Carolina, Rutyleia Alves-Soares, Amauri Barbosa da Silva-Junior, Antonio Lucas Fernandes-Leal, Maria Natália Feitosa de Sousa, Kerly Shamyra Silva-Alves, José Henrique Leal-Cardoso, et al. "ALTERAÇÕES ELETROFISIOLÓGICAS DO SEGMENTO ABDOMINAL DO NERVO VAGO DE RATOS INDUZIDOS AO DIABETES POR STZ NO PERÍODO ADULTO." In Encontro Anual da biofisica 2019. São Paulo: Editora Blucher, 2019. http://dx.doi.org/10.5151/biofisica2019-36.

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Alves-Soares, Rutyleia, Lívia Carolina Amâncio, Yuri de Abreu Gomes-Vasconcelos, Amauri Barbosa da Silva-Junior, Antonio Lucas Fernandes-Leal, Maria Natália Feitosa-de-Sousa, Alan Hílame Diniz-Gomes, et al. "ALTERAÇÕES ELETROFISIOLÓGICAS NO POTENCIAL DE AÇÃO COMPOSTO DO NERVO CIÁTICO DE RATOS NO DIABETES MELLITUS INDUZIDO POR STZ NO PERÍODO ADULTO." In Encontro Anual da biofisica 2019. São Paulo: Editora Blucher, 2019. http://dx.doi.org/10.5151/biofisica2019-35.

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Hsieh, Yi-Cheng, and Jeffrey D. Zahn. "On-Chip Microdialysis System With In-Line Sensing Capabilities." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80859.

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Microdialysis probes have been used for diabetes treatment as continuous monitoring system coupled to a glucose sensor. An on-chip microdialysis system with in-line sensing electrodes is demonstrated. The response time of the microdialysis system was characterized and the permeability of the polycarbonate membrane (100nm pore size) to glucose was determined to be 2.53 μm/s (std:0.372 μm/s). As a first step towards greater biosensor integration with this miniaturized microdialysis system, a stacked system with in-line sensing electrodes was developed. Impedance electrodes within the microchannels were used to determine fluid resistance from a dialyzed phosphate buffered saline (PBS) solution, which characterizes solution conductivity as a function of PBS concentration. The permeability of the membrane to the salt ions was obtained as 0.74 μm/s (15 nm pores). Subsequently, experiments measuring PBS dialysis in the time-domain at 60% recovery were conducted. The PBS concentration of the reservoir was changed in either a step response or sinusoidally with an 800 second period. The subsequently measured impedance indicates that the system is able to continuously track concentration changes in the reservoir with a 180 second system response delay. Most of this delay is due to the dead volume within the tubing between the syringe pumps and the microsystem In addition the predicted response was modeled using linear systems theory and matches the experimental measurements. This system is expected to have the proper sensitivity to track physiologically relevant concentration changes of biomolecules such as glucose (which has a physiological maximum change rate of ~4mg/dL-min with a periodicity of 1 hour or greater) with minimal lag time and amplitude reduction.
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