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Dissertations / Theses on the topic 'Study the Pathogenesis of a Disease'

Author: Grafiati

Published: 26 October 2023

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1

Cheung, Nga-yin Annie, and 張雅賢. "Pathobiological study of gestational trophoblastic disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31981690.

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2

Alexopoulou, Zoi. "The study of the deubiquitinase USP8 in Parkinson's disease pathogenesis." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:47c2941b-5232-4bd0-92fa-e59aac16af7c.

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Parkinson's disease is the second commonest neurodegenerative disease currently treated symptomatically. It is a multifactorial disease involving mechanisms ranging from protein aggregation to mitochondrial dysfunction, oxidative stress and dopamine dysregulation. The levels of α-synuclein have been causatively linked to the development and progression of Parkinson's disease. Therefore α-synuclein lowering strategies are valid approaches in Parkinson's disease. Neuropathologically, Lewy Bodies in the vulnerable substantia nigra of Parkinson's disease patients are less ubiquitinated

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3

Hofner, Maureen Catherine. "A study of foot-and-mouth disease virus pathogenesis in cattle." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338844.

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4

Goldman, Jonathan Howard. "A study of immune mechanisms in the pathogenesis of idiopathic dilated cardiomyopathy." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339209.

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5

Higgins, Damien. "Chlamydial Disease of the Koala: A Study of Pathogenesis and Host Response." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/25063.

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Chlamydial infection occurs commonly in koalas (Phascolarctos cinereus) and, as in humans, can cause proliferative conjunctivitis and disease of the urinary and reproductive tracts. Past studies suggest that increased expression of chlamydial disease in koalas is associated with habitats disturbed by humans, but the mechanisms and specific factors influencing susceptibility of koalas to disease have not been studied in detail. This thesis aims to further the goal of describing pathogenic mechanisms and the host-pathogen-environment interaction for chlamydial disease in koalas by developing tec

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6

Thunberg, Therese. "Study of pathogenesis and immune response in human Puumala virus infection." Doctoral thesis, Umeå universitet, Institutionen för klinisk mikrobiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76706.

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Hantaviruses can cause two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses are spread to humans mainly through inhalation of infectious virions, secreted from infected rodents. The human diseases are characterized by an increased capillary leakage syndrome. Hantaviruses are known to infect endothelial cells, but they are non-cytopathogenic. The mechanism behind human disease is not well understood, but an overactive immune response is implicated in the pathogenesis. The aim of my thesis has been to investigate par

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7

Chen, Liqiong. "The development of a novel in vitro model of human liver for the study of disease pathogenesis." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11020/.

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The development of systems for the long term in vitro culture of functional liver tissue is a major research goal. The central limitation of experimental systems to date has been the early de-differentiation of primary hepatocytes in cultures. Several factors including cell-cell interaction, cell-matrix interaction, soluble factors and 3D structures have been identified as the keys to overcome this limitation. The first aim of this project is to compare the established 3D model, co-culture of hepatocytes and hepatic stellate cells (HSCs) on PDLLA coated surfaces, to other best available system

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8

Jacob, Ashok J. "A study of the prevalence, pathogenesis and natural history of heart muscle disease associated with HIV infection." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20587.

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Heart muscle disease was found in 14.2% of HIV patients and took three principal forms - dilated cardiomyopathy, borderline left ventricular dysfunction and isolated right ventricular dilation. Dilated cardiomyopathy was associated significantly with a very low CD4 count indicative of late stage HIV disease. It was invariably irreversible. In contrast, some patients with borderline left ventricular dysfunction and isolated right ventricular dilation subsequently reverted to normal. The latter was usually related to pressure or volume overload of the right ventricle rather than to a primary myo

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9

Brown, Graham Alfred. "A study of bovine herpesvirus 1 pathogenesis using laboratory models." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304239.

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10

Sun, Jun. "Study of neuronal networks and mechanisms implicated in locomotor reactivity and Parkinson's disease pathogenesis in the Drosophila model." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS434.

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La maladie de Parkinson (MP) est un trouble moteur neurodégénératif progressif, caractérisé par la perte des neurones dopaminergiques (DA) de la substance noire et la présence d'inclusions cytoplasmiques composées principalement de synucléine α (syn α), appelées corps de Lewy. Les objectifs de mon travail de thèse étaient de caractériser un modèle de la MP développé chez la drosophile afin de comprendre comment l'accumulation de syn α dans les neurones DA peut perturber progressivement la locomotion et de rechercher de nouvelles protéines neuroprotectrices. Nous avons d'abord identifié des rés

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11

Ferrari, Eleonora. "Characterization of mouse models to study the pathogenesis of celiac disease and the role played by the dysregulation of the intestinal microbiota." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/127592.

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Celiac disease (CD) is a permanent intolerance to dietary protein, gluten, from wheat rye and barley. It occurs in about 1% worldwide population, in genetically predisposed individuals bearing human leukocyte antigen DQ2/DQ8. Although gut epithelial cell stress and the innate immune activation are responsible for the breaking oral tolerance to gliadin, the gluten component, the exact mechanisms through which gliadin can stimulate CD onset are still unclear. Here I show how is important to identify in vivo preclinical models of CD to study its pathogenesis, at molecular level. The increasing pr

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12

Wheeler, Ennis Edmund. "A study of the role of 5-hydroxytryptamine (5-HT, seratonin) in the aetiology and pathogenesis of coeliac disease." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278095.

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13

Cardoso, da Silva Danielle [Verfasser]. "Gene expression analysis approaches to study barrier dysfunction in celiac disease and pathogenesis of colitis-associated cancer / Danielle Cardoso da Silva." Berlin : Freie Universität Berlin, 2021. http://nbn-resolving.de/urn:nbn:de:kobv:188-refubium-31985-3.

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14

Patel, Milan K. "A Study of Host Factors that Affect Herpes Simplex Virus 1 Pathogenesis: The Role of Cold Sore Susceptibility Gene 1 (CSSG1) in HSV1 Replication." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/944.

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Numerous factors that affect herpes simplex virus 1 (HSV1)-mediated pathogenesis have been identified. Such factors directly impact the replication of HSV1 as well as modulate host immune responses following HSV1 infection. In this work, I characterize how HSV1 replication is impacted by expression of the protein encoded by C21orf91, or “Cold Sore Susceptibility Gene” (CSSG1), that has been linked to HSV1 reactivation in humans. I investigated expression of CSSG1 mRNA expression in various tissues and found that CSSG1 mRNA was present in several tissues of importance in HSV1 disease, including

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15

Njelekela, Marina Magdalane Alois. "The Pathogenesis of Lifestyle Related Diseases in Developing Countries : Results From CARDIAC Study in Tanzania." Kyoto University, 2003. http://hdl.handle.net/2433/148928.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第10291号<br>人博第178号<br>14||142(吉田南総合図書館)<br>新制||人||44(附属図書館)<br>UT51-2003-H712<br>京都大学大学院人間・環境学研究科人間・環境学専攻<br>(主査)教授津田謹輔, 教授谷口貞善, 教授森谷敏夫<br>学位規則第4条第1項該当

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16

Gonzalez, Jorge Del Pozo. "A study of the aetiology and control of rainbow trout gastroenteritis." Thesis, University of Stirling, 2009. http://hdl.handle.net/1893/1081.

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Disease has been identified as a major problem in the aquaculture industry for the welfare of the fish stocked as well as for its economic impact. The number of diseases affecting cultured fish has increased significantly during recent years with the emergence of several conditions that have added to the overall impact of disease on the industry. Frequently, a lack of scientific knowledge about these diseases is compounded by an absence of effective treatment and control strategies. This has been the case with rainbow trout gastroenteritis (RTGE), an emerging disease of rainbow trout (Oncorhyn

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17

Cysique, Lucette Adeline Juliette St Vincent's Hospital UNSW. "Aids dementia complex in the era of highly active antiretroviral therapy: a neuropsychological study." Awarded by:University of New South Wales. St. Vincent's Hospital, 2005. http://handle.unsw.edu.au/1959.4/22074.

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The aim of the thesis was to undertake an evaluation of the neuropsychological functioning of non-demented and demented patients with advanced HIV-infection who have been treated with Highly Active Antiretroviral Therapy (HAART) for several years. One hundred and one non-demented HIV-infected individuals and 23 patients with mild or moderate AIDS Dementia Complex (ADC), from the outpatient clinics and Neurology department at St. Vincent's Hospital, Sydney, Australia were randomly selected to participate in a prospective study of the neurological and neuropsychological complications of HIV dise

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18

Cheung, Kwok-ho Alvin, and 張國豪. "Genetic and pharmacological approaches to study the role of the polyolpathway enzymes in diabetic and ischemic retinopathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558617.

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19

Fossati, S. "Acute cardiovascular effects of exposure to airborne particulate matter : a study of possible pathogenetic mechanisms." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/64549.

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Introduction Increased levels of particulate matter air pollution (PM) have been associated with increased cardiovascular morbidity and mortality, especially in elderly adults and in people suffering from cardiovascular or lung diseases. The mechanisms behind these effects are still unknown, although some hypothesis have been postulated that include a modification of autonomic regulation of heart rhythm and the induction of arrhythmic events. Which fraction of PM is the most harmful is still controversial, and few studies investigated the role of personal exposure to different fractions, and

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20

Lindell, Gert. "Smoking and peptic ulcer disease a clinical and experimental study with special reference to possible pathogenetic mechanisms induced by smoking /." Lund : Dept. of Surgery, Lund University, 1992. http://books.google.com/books?id=YT9sAAAAMAAJ.

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21

Bueno, Carmen Ruiz de Valbuena. "Fabry disease: pathogenesis and hispathology." Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63774.

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22

Aula, Nina. "Molecular pathogenesis of Salla disease." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/aula/.

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23

Bueno, Carmen Ruiz de Valbuena. "Fabry disease: pathogenesis and hispathology." Tese, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63774.

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24

Clark, Kim Michelle. "Mitochondrial DNA disease : pathogenesis and treatment." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262993.

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25

Turner, C. "The molecular pathogenesis of Huntington's disease." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/19056/.

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Huntington’s Disease (HD) is caused by an expansion in the CAG repeats of the huntingtin gene. This thesis describes an Ecdysone cell model which expressed inducible wild type (WT) and mutant (MT) N-terminal huntingtin (htt) in HEK 293 cells and constitutive EYFP full length (FL) htt in SH-SY5Y cells. WT and MT EYFP FL htt was diffusely localised to the cytoplasm whereas endogenous FL htt and N-terminal htt localised to the nucleus and cytoplasm suggesting that htt has a role both in the nucleus and cytoplasm and EYFP inhibited nuclear translocation. Nterminal htt partially colocalised with ve

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26

Näpänkangas, J. (Juha). "Pathogenesis of calcific aortic valve disease." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526223520.

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Abstract Calcific aortic valve disease (CAVD) represents a disease spectrum, ranging from mild aortic valve sclerosis to severe obstructive aortic stenosis (AS), associated with a high risk of myocardial infarction and cardiovascular death. It is a common disease in the Western countries, and with their aging populations, its prevalence is likely to increase. Today, CAVD is recognized as an actively regulated disease. Mechanical stress and endothelial injury are the initiating factors, followed by lipid accumulation and oxidation, leading to inflammation, fibrosis and calcification. Ultimately

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27

Critchley, Alison. "Congenital disorders of glycosylation and disease pathogenesis." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424758.

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28

Johal, Shawinder Singh. "The pathogenesis of Clostridium difficile induced disease." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403400.

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29

Cramer, Paige E. "Nuclear Receptor Activation and Alzheimer's Disease Pathogenesis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1332962440.

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30

Suleman, Verjee Liaquat. "Myofibroblasts and the pathogenesis of Dupuytren's disease." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6119.

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Dupuytren’s disease is defined in Green’s Operative Hand Surgery as a condition of the hand characterised by the development of new tissue in the form of nodules and cords. Hand function can be significantly impaired and whilst the mainstay of treatment is surgery, recurrence has been reported in approximately 40-50% of patients. Myofibroblasts are central to the pathogenesis of Dupuytren’s disease although what regulates the myofibroblast phenotype during Dupuytren’s disease remains unclear. This thesis set out to test the hypothesis that the myofibroblast phenotype in Dupuytren’s disease is

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31

Ventham, Nicholas Toby. "Epigenetic biomarker discovery in inflammatory bowel disease : unearthing clues for disease pathogenesis?" Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23608.

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Epigenetic alterations including DNA methylation and microRNAs may provide important insights into gene-environment interaction in complex immune diseases such as inflammatory bowel disease (IBD). An integrative genome-wide approach was used to analyse whole blood genetic, DNA methylation and gene expression data in 240 newly diagnosed IBD patients and 190 controls. Using the Illumina 450k array, differences in whole blood DNA methylation were observed in IBD cases versus controls including 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs). The top D

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32

Zheng, Lin. "Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease." Doctoral thesis, Linköpings universitet, Geriatrik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73412.

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Alzheimer’s disease (AD), the major cause of senile dementia, is associated with progressive formation of neurofibrillary tangles and extraneuronal plaques composed of amyloid beta peptide (Aβ). Aβ has been also found within Alzheimer neurons in association with the lysosomal system, an acidic vacuolar compartment possessing numerous hydrolytic enzymes. Lysosomes have been shown to be involved in both the formation of Aβ and its toxicity to neurons. Another line of evidence implicates oxidative stress as an important factor in the development of AD. It is reported that oxidative damage is one

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33

Abu-Aliat, Abdullah Saeed Mohammed Sabrah. "Fungi and bacteria in pathogenesis of nail disease." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406193.

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34

Shadbolt, Tammy. "The pathogenesis of Tasmanian Devil facial tumour disease." Thesis, Royal Veterinary College (University of London), 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766334.

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35

Beavan, M. S. "Glucocerebrosidase mutations and the pathogenesis of Parkinson disease." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1470802/.

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To date, a mutation of the glucocerebrosidase gene (GBA) is the strongest genetic risk factor associated to Parkinson’s disease (PD). This leads to my prospective cohort study of a GBA mutation positive cohort for early features of PD. This study indicates that as a group, GBA mutation positive individuals show deterioration in clinical markers consistent with the prodrome of PD. I have generated cell culture models from individuals within the clinical cohort studied, in order to delineate the molecular mechanism of mutant GBA to the pathogenesis of PD. My results on skin fibroblast cultures r

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36

Boutin, Samuel R. 1952. "Molecular pathogenesis of Helicobacter hepaticus induced liver disease." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/35696.

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Thesis (Ph. D. in Molecular and Systems Bacterial Pathogenesis)--Massachusetts Institute of Technology, Biological Engineering Division, 2005.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references.<br>Helicobacter hepaticus infection of A/JCr mice is a model of liver cancer resulting from chronic active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions in H. hepaticus infected and control male A

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37

Hart, P. E. "Human mitochondrial disease : from pathogenesis to therapeutic intervention." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444782/.

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The spectrum of diseases caused by mitochondrial dysfunction is very broad and encompasses the archetypal mtDNA mutation diseases, mutations of nuclear genesencoding mitochondrial proteins (including those of the oxidative phosphorylation system), and a variety predominantly neurodegenerative diseases in which the primary cause of mitochondrial dysfunction remains undefined. The last two decades have seen an explosion in our understanding of the archetypal i mitochondrial disorders. Attention has now focused on the nuclear encoded mitochondrial disorders. Furthermore, nuclear factors may be of

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38

Mutsaers, Chantal. "Mechanisms of disease pathogenesis in Spinal Muscular Atrophy." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9774.

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Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, however the major pathological hallmarks of SMA are focused on the neuromuscular system, including a loss of lower motor neurons in the ventral horn of the spinal cord and atrophy of skeletal muscle. At present there is no cure for SMA. Most research to date has focused on examining how low levels of SMN lead to pathological changes in motor neurons, therefore the contribution

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39

Colaço, Alexandria Nicole. "Niemann-Pick Type C disease : pathogenesis and therapy." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:d75bf036-acc9-4c6f-89ad-7708d2996937.

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Niemann-Pick disease Type C is a rare, lysosomal storage disorder caused by defects in either NPC1 (95% of cases) or NPC2, and characterized by progressive neurodegeneration that ultimately results in premature death. The function of the NPC1 protein still remains poorly understood and how the NPC1 or NPC2 proteins interact, or the functions of the pathways they regulate still remains unknown. We have found unexpected links between NPC and other human diseases - particularly Tangier disease, suggesting that the NPC cellular pathway is more broadly involved in human disease than previously sugg

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40

Funk, Kristen E. "Alzheimer’s Disease Pathology as a Clue to Pathogenesis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343231184.

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41

Xia, Qiong. "Inflammatory Mediators in the Pathogenesis of Vascular Disease." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16742.

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This thesis explores the role of inflammation in vascular disease in human subjects. Three disparate models of vascular disease have been explored: atherosclerotic vascular disease, which examined the common carotid artery, was compared to two forms of hereditary thoracic aortic aneurysm, one of purely hereditary origin, Marfan syndrome (MFS), and the other of a combined hereditary and haemodynamic stress aetiology, bicuspid aortic valve (BAV)-associated thoracic aortic aneurysm. Inflammation was found to be an important contributor to the pathogenesis in all cases. To examine inflammation in

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Culver, Emma L. "Natural history and pathogenesis of IgG4-related disease." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:31650f77-91ca-4fb9-8dbe-88bad1948145.

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IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition characterised by elevated serum IgG4 and an abundance of IgG4 plasma cells in involved organs. The natural history of disease and pathogenic mechanisms are poorly understood, and are explored in this thesis. The diagnosis of IgG4-RD is a challenge. Evidence to support a serum IgG4 level of 2.8g/l in differentiating IgG4-RD from non-IgG4-RD conditions, a serum IgG1:IgG4 ratio of 0.24 in differentiating IgG4-sclerosing cholangitis from primary sclerosing cholangitis with elevated serum IgG4, and the role of serum IgE in th

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Sun, Xiulian. "Molecular mechanism of Alzheimer's disease pathogenesis in Down syndrome." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31167.

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Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia. Neuritic plaques and neurofibrillary tangles are the two hallmarks of AD neuropathology. The molecular mechanism underlying AD pathogenesis remains unknown. It is believed that deposition of amyloid β (Aβ) protein in the brain plays a pivotal role in AD pathogenesis. Aβ, the central component of neuritic plaques, is derived from β-amyloid precursor protein (APP) by sequential cleavages by β- and γ-secretase. Nearly all individuals with Down Syndrome (DS) show characteristic AD pathological changes after

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Iancu, Simona Ioana. "Epithelial mechanisms in the microbial pathogenesis of periodontal disease." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/epithelial-mechanisms-in-the-microbial-pathogenesis-of-periodontal-disease(90dedf1b-d1dd-455b-92ff-47c8af10b995).html.

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Periodontitis, a major cause of tooth loss, is a bacterially induced inflammatory disease that has been associated with certain bacterial species. The aim of this thesis was to identify the epithelial mechanisms activated by commensal and periodontal pathogens to determine which signalling pathways, transcription factors, and pro-inflammatory cytokine responses are associated with periodontitis. The H400 gingival epithelial cell line was infected with the health-associated Actinomyces naeslundii and periodontopathogens Fusobacterium nucleatum and Porphyromonas gingivalis. Differential pathway

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Angel, Carole Ann. "The aetiology, pathogenesis and cellular origin of Hodgkin's disease." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/29546.

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Hodgkin's disease (HD) is a lymphoproliferative disorder characterised by the presence of the Reed-Sternberg cell and its variants (HRS cells) in a polymorphic cellular background. Cure can now be achieved in more than 85% but the aetiology, pathogenesis and cellular origin have remained unclear despite extensive research. This thesis describes the results of histological, immunhistological and molecular biological studies of Hodgkin's disease. Previous immunohistological studies had suggested that one of the subtypes, nodular lymphocyte predominant HD, was a separate disease entity and was of

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Khan, Usman. "Studies on the pathogenesis of cerebral small vessel disease." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539378.

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Chinnery, Patrick Francis. "The pathogenesis, investigation and management of mitochondrial DNA disease." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324935.

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48

Flanagan, Paul Kevin. "Bacteria-macrophage interactions in the pathogenesis of Crohn's disease." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3008673/.

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Crohn's disease (CD) is associated with defective innate immunity, including impaired neutrophil chemotaxis, and mucosal invasion by bacteria, particularly E. coli that replicate inside macrophage phagolysosomes. In this thesis several hypotheses were tested: (i) that CD macrophages might be defective at killing and or responding to Gram-negative bacteria, particularly E. coli; (ii) that killing of phagocytosed bacteria within macrophages might be enhanced by drugs such as hydroxychloroquine (HCQ) (previously shown to raise intravacuolar pH), and vitamin D (previously shown to enhance macropha

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Wasylenko, Theresa Anne. "Understanding Huntington's Disease pathogenesis using next generation sequencing analyses." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/103260.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, February 2016.<br>Cataloged from PDF version of thesis. "February 2015."<br>Includes bibliographical references (pages 215-240).<br>Huntington's disease is one of nine expanded (CAG) repeat disorders. The expansion in Huntington's disease lies in the first exon of the huntingtin (HTT) gene and is pathogenic when (CAG)>/= 40 . Individuals with Huntington's disease develop motor, cognitive, and psychiatric symptoms in adulthood. These symptoms progress for approximately 15 years at which time they become fatal. The cli

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50

Sweet, D. G. "Studies on the pathogenesis of neonatal chronic lung disease." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395367.

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