Dissertations / Theses: 'Structural studies'

1

Naseer, Abeer. "Structural studies of higher order DNA structures." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515807.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Bennett, J. E. "Structural and compositional studies of novel ribbon structures." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596574.

Full text

Abstract:

This thesis documents the results of a structural and compositional study of selected mixed metal oxides possessing novel structures based upon 'ribbons' of corner sharing metal-oxygen octahedra. The techniques employed to characterise the specimens of interest have included Powder X-ray Diffraction (PXRD). High Resolution Transmission Electron Microscopy (HRTEM) and Energy Dispersive X-ray Spectroscopy (EDS). Compositional analysis of specimens containing strontium, lanthanum and titanium has been achieved to a high degree of accuracy using EDS analysis in the electron microscope. A mathematical technique based upon the intensity ratios of the X-ray emission lines has been developed to overcome the problem of overlapping lanthanum L and titanium K peaks in the X-ray emission specimen. The viability of the new technique has been proven using well characterised test specimens containing all three elements. An in-depth study of two compounds in the SrO-La₂O₃-TiO₂ system, Sr₃La₂Ti₂O₁₀ and Sr₈La₄Ti₅O₂₄ has been performed. Evidence from high resolution imaging and electron diffraction has confirmed that threes phases possess composite layer structures based upon corner sharing ribbons of TiO₆ octahedra. Their status as the n=4 and n=5 members of a homologous series Sr_2n-2La₄Ti_nO_4n+4, where the parameter n represents the number of TiO₆ octahedra in the ribbons, has also been established using EDS. However, results also suggest that these compounds may be metastable. The effect of niobium substitution on the structure of the n=1 Aurivillius phase, Bi₂WO₆, has also been investigated. Results from HRTEM have shown up to 25% of the tungsten can be substituted by niobium without any observable effect on the Aurivillius structure. Upon 50% niobium substitution, it appears that a structural modification takes place, as high resolution imaging and electron diffraction reveal a superstructure on the (012) or (013) planes of a Bi₂WO₆ sub-cell, which can be attributed to the presence of steps in the Aurivillius matrix at regular intervals.

APA, Harvard, Vancouver, ISO, and other styles

3

Moran, Stephen John. "Structural Studies of Translation." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491502.

Full text

Abstract:

Cellular translation is one of the fundamental processes that make life possible. It is the point at which stored information, coded by the nucleic acid, is read and converted into three-dimensional functional proteins. By linking together the correct sequence of amino acids, spontaneous order is created. It is truly a remarkable process. The plechanism by which this is achieved can be understood in physical terms, by the structure of the molecular machinery involved. These structures are dynamic and elegant and we can observe them in action. Through the application of the techniques of structural biology I undertake some structural studies of the translation process, focussing on the mechanism in eukaryotes. In the first instance I use X-ray crystallography to determine the structure of an enzyme that demonstrates a novel function in translation, Nhm1. This protein is an enzyme that removes the cap structure from messenger RNA, which is an important determinant of the cellular stability of this molecule. Usually this class of enzyme works only on free cap structures, after the message has been degraded. Four forms of the molecule are investigated: an apo form, a mutant form, a GTP-bound form and a cap-bound form. The structure is compared to other decapping enzymes to try and identify the basis of its novel function. Next I use cryo-electron microscopy to investigate how viral RNA can manipulate its host's ribosomes during translation. Many viral RNAs use RNA secondary structure to physically shift the ribosome back one base (-1) between reading frames. By visualising the apo mammalian ribosome, as well as a complex with a viral pseudoknot structure and a complex with a stemloop structure formed from deletion of loops in the pseudoknot I have been able to dissect out the changes induced by a functional pseudoknot structure. This has revealed a mechanistic explanation of pseudoknot function in -1 frameshifting and provided the first insights into the functional interaction of the ribosomal translocase with the tRNA during translocation. In addition I have helped develop a reconstruction method that can deal with the problems associated with preferred particle orientations on a cryo-EM grid and begun investigations into the structures of eukaryotic initiation factor 3 (eIF3) and a kinase important in regulating translation initiation, Mnkl.

APA, Harvard, Vancouver, ISO, and other styles

4

Ang, S. G. "Structural studies on peptides." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233709.

Full text

Abstract:

The work presented in this thesis is primarily concerned with solving structural problems in peptides using a combination of classical chemical methods, mass spectrometry and nuclear magnetic resonance spectroscopy (NMR). Chapter One gives brief descriptions of the applications of fast atom bombardment mass spectrometry (FABMS) and NMR to the solution of structural problems in peptides. Chapter Two of this thesis describes the elucidation of the structure of vancomycin-type antibiotic, OA-7653, isolated from Streptomyces hygroscopicus subsp. hiwasaensis subsp. nov. Nishida. Chapter Three examines the interaction of vancomycin and OA-7653 with peptide cell-wall analogues, N-acetyl-D-alanyl-Dalanine and di-N-acetyl-L-lysyl-D-alanyl-D-alanine, in aqueous solutions by NMR and ultraviolet (UV) difference spectroscopy. In Chapter Four, the technique of FAB mapping was applied to study the amino acid sequence of actinidin, a proteolytic enzyme isolated from the fruit of Actinidiaz chinensis (commonly known as kiwi fruit). Also included in this chapter are mass spectrometric studies on model peptides to examine the conditions for accurate quantitation of phosphate content of peptides. Finally, structural and quantitation studies performed on phosphorylated peptides from the enzyme glycogen synthase are described.

APA, Harvard, Vancouver, ISO, and other styles

5

Spraggon, Glen. "Structural studies on proteins." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297295.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Cockburn, Joseph John Berry. "Structural studies on bacteriophages." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442832.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Diprose, Jonathan Marlborough. "Structural studies on orbiviruses." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365819.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Wang, Wei. "Structural studies on chitosan." Thesis, Nottingham Trent University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389687.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Wilkinson, Kay W. "Structural studies on metalloenzymes." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364295.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Warburton, J. D. "Structural studies on carotenoproteins." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377126.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Al-Saleh, S. S. H. "Structural studies on rhodopsins." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381264.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Chapman, Allan Douglas Michael. "Structural studies of dehydrogenases." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310587.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Weixlbaumer, Albert. "Structural studies on translation." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611985.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Lee, Joo Hee. "Structural studies of glasses." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627292.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Booth, Ewan D. "Structural studies in DNA." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/15191.

Full text

Abstract:

Base pair mismatches may be formed during replication or genetic recombination. Not all mismatched base pairs are repaired with the same efficiency, in particular the A.G. mismatch is consistently under repaired. Why the A.G. mismatch is poorly repaired is not clear, although previous work has suggested the mismatch is conformationally flexible. In the present study the A.G. mismatch in the sequence dCGCAAATTGGCG was examined by X-ray crystallography and pH dependant UV melting studies. Crystals were grown at pH 6.6. The base pair has an A (anti).G(syn) conformation. From the pH dependant UV melting studies it is likely this is a protonated AH&43 (anti).G(syn) base pair formed by protonation of the N(1)- atom of adenine. The G (syn) conformation is stabilised by hydrogen bonding to a network of solvent molecules in the major and minor grooves. A parallel investigation of the A.l mismatch was performed. The oligonucleotide dCGCAAATTIGCG was crystallised. An A (anti).l(syn) base pair may be indicated, pH dependent UV melting profiles suggest the existence of a protonated base pair. 5-Bromouracile is strongly mutagenic forming mismatches with G. The G.BrU mismatch has been reported to form a wobble base pair although other forms are possible. The oligonucleotide dCGCGAATTBrUGCCG was synthesised and used in pH dependent UV melting studies. These suggest that there is little or no contribution to the base pair from non-wobble, ionised or enolised, forms. Frame shift mutations may arise from nonmatched bases in DNA. A series of tridecameras was synthesised for analysis by X-ray crystallography; dCGCGTAATTCGCG, dCGCGBrUAATTCGCG, dCGCGTAATBRUCGCG and dCGCGTAATTBrUCGCG. It was hoped to determine the looped out, stacked or nonmatched nature of the additional bases. 2-Amino-2'-deoxyadenosine (dA') is an analogue of dA. Base pairs formed between A' and T contain three hydrogen bonds and are A.T like in the major groove and G.C like in the minor groove. The additional hydrogen bonding affords extra stability to A'. T base pairs relative to A.T base pairs. Z-DNA is formed by d(GC)_n sequences but not by d(AT)_n sequences. The mixed sequence oligonucleotide dCA'TA'TG was made for X-ray crystallographic investigation and UV melting studies. It was hoped this would crystallise as Z-DNA. Recently X-DNA has been investigated. This can be formed by poly(dA-dT) under stringent conditions due to the effects of salt or alcohols. X-DNA was first identified by its CD spectrum. Similar CD spectra have been observed for poly(dA'-dT) closer to physiological conditions. The oligonucleotides d(TA')_n n = 2,3,4 were synthesised for X-ray crystallography, d(TA')₄ was also investigated by CD spectroscopy. This showed the ability of the oligonucleotide to form X-DNA. The additional stability of dA' oligonucleotides gives them potential used as stable short genetic probes. A series of oligonucleotides was made, these hybridised successfully under conditions where the native sequences failed to. A new phosporamidite for the synthesis of dA' oligonucleotides was developed. This overcomes the problem of acid catalysed depurination of dA' residues during solid phase phosphoramidite DNA synthesis, di-n-butylformamide dimethylacetal was used to protect the N⁶ function. This was shown to be stable to the detritylation conditions encountered in DNA synthesis.

APA, Harvard, Vancouver, ISO, and other styles

16

Elbrghathi, Abdelhamid. "Structural studies on dehydrogenases." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7406/.

Full text

Abstract:

The amino acid dehydrogenase superfamily has good potential for biotechnological use for example, either as enzymes for the production of non-natural amino acids, or for use as biosensors. Despite many years work on this family, there is still a gap understanding aspects of both substrate and cofactor binding and reaction mechanism. The crystal structures of M. smegmatis Glutamate dehydrogenase (GluDH) have been determined in two crystal forms, one of a ternary complex (GluDH/NADP+/2oxoglutarate) at 1.64A, and one of a binary complex (GluDH/NADPH) at 1.78A. The binary complex structures of C. symbiosum GluDH, with NAD+ and L-glutamate have also been solved at 1.80 A and 1.24A respectively. Comparison of these structures has allowed the nature of coenzyme specificity in GluDHs to be structurally characterized. Analysis of M. smegmatis GluDH/NADP+/2oxoglutarate ternary complex showed that 2-oxoglutarate bound to the enzyme as the gem-diol in an extended conformation, which mimics the structure of the carbinolamine intermediate. This structure, together with the high resolution C. symbiosum GluDH/L-glutamate complex structure, where the substrate binds in a compact, curved conformation have given valuable insights into the progress of the reaction. They show that the substrate alters its conformation during the reaction, explaining how the abortive reduction of the keto acid to the hydroxy acid is prevented, and showing the stereochemistry of attack by ammonia on the keto acid substrate, aspects of the mechanism that have been poorly understood. In addition, the structure of the AADH family member Bacillus sphaericus phenylalanine dehydrogenase in complex with NADH has been determined. Furthermore, initial experiments towards the structure of mycobacterium smegmatis typeII NADH: menaquinone oxidoreductase, which is a potential anti bacterial drug target are described.

APA, Harvard, Vancouver, ISO, and other styles

17

Jamaluddin, Haryati. "Structural studies on glycosyltransferases." Thesis, University of Bath, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441452.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

de, Morais Cabral João Henrique Resende de Oliveira. "Structural studies on two lipocalins." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/28657.

Full text

Abstract:

The number of proteins being included in the lipocalin structural family has been steadily increasing since the solution of the structures of beta-lactoglobulin and retinol-binding protein. The family now comprises some 21 proteins and these come from many different sources and display a variety of characteristics. The work described here focused on two of those proteins, beta-lactoglobulin (Blg) and apolipoprotein D (apo D). The structure of bovine beta-lactoglobulin from the trigonal crystals grown at pH 7.8, space group P3₂21, presents several aspects that are in disagreement with previous work, in particular the positioning of the bound retinol in the surface of the protein and the observation that the protein was in its monomeric form. We have checked these findings independently by extending the resolution of a 6 AA x-ray structure. A 3.0 AA model is now available though still in the refinement stages. Not surprisingly it was found that the protein is indeed in the dimeric form and that the arrangement of the dimer is very similar to the one found in BlgY (orthorhombic crystal form), the other independently determined structure. Changes were observed in the threading of the sequence, in particular between residues 75 and 32 where movements of as much as five residues are found, and in the C-terminus between 141 and 150 where a shift of one residue is observed along a β-strand. These changes result in an overall increase of the hydrophobilcity of the pocket. In parallel, cocrystallization of Blg with a variety of ligands has been successful in at least one case where density is evident in the binding cavity. Human apolipoprotein D is present in the fluid of cysts formed during gross-cystic-disease, which is the most common breast disease in premenopausal women, and is a potential biological marker for breast cancer. The protein is found as well, associated with the lipoproteic system in the blood and is produced in high amounts in regenerating rat peripherial nerves.

APA, Harvard, Vancouver, ISO, and other styles

19

Parrish, Jonathan C. "Structural studies of cytochrome c." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq24760.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Larsson, Anna. "Structural Studies of Three Glycosidases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6339.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Pearce, Clive Michael. "Structural studies on natural products." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259614.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Verrall, Diane Jane. "Structural studies of chalcogenide glasses." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333353.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Gladden, L. F. "Structural studies of inorganic glasses." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233932.

Full text

Abstract:

The present work has been concerned with a study of the structure of germanium and silicon dichalcogenide glasses. Initially, the aim of this research was to obtain direct structural evidence of reversible photostructural changes in bulk germanium chalcogenide glasses. However, having confirmed the existence of such changes using EXAFS and neutron scattering techniques, it became obvious that a more comprehensive understanding of the as-quenched, annealed glass structure is required before a valid interpretation of the data can be made; in particular, the extent of medium-range order in these systems is of interest. Although limited to few examples at the moment, the potenital of both structural modelling and NMR studies for solving such problems has been investigated in a variety of inorganic glass systems, and these approaches can now be extended to those glasses exhibiting photostructural changes. Modelling studies of the structure of a-SiSe₂ have shown that the total correlation function T(r) is sensitive to different structural features in the generated glass structure. The present studies heavily favour a structure based on chains of edge-sharing (SiSe₄) tetrahedra. A degree of spatial correlation is required between the chains, such as can only be obtained by short lengths of parallel chains 'pinned' by corner-sharing tetrahedra. ²⁹Si NMR studies of vitreous silica have shown that water, incorporated into the SiO₂ network as OH, acts as a major source of spin-lattice relaxation in this system. Numerical methods of self-calibration ('phasing') and removal of data truncation and lineshape apodization effects have been investigated, thereby enabling quantitative information concerning the Si-O-Si bond-angle distribution in silica to be obtained. Although these algorithms are presented with reference to NMR spectroscopy, their extension to other branches of spectroscopy is obvious. NMR has also been used to probe defect states in a-Se. ⁷⁷Se spin-lattice relaxation time data provide evidence of a defect state (perhaps a VAP) in equilibrium with C_1⁰ centres in the glass.

APA, Harvard, Vancouver, ISO, and other styles

24

Rohou, Alexis Lawrence. "Structural studies of Î±-latrotoxin." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441979.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Da, Fonseca Paula Cristina Alves. "Structural studies of cyanobacterial PSII." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249460.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Long, Alexandra. "Structural studies on penicillin biosynthesis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393574.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Tate, John Graham. "Structural studies on bovine enterovirus." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318546.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Grimes, Jonathan Mark. "Structural studies on Bluetongue virus." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260746.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Zaccai, Nathan R. "Structural studies on immune receptors." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393447.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Bartlam, Mark Gerrard. "Structural studies of amyloid proteins." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342536.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Ren, Jingshan. "Structural studies on biological macromolecules." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334959.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Anthis, Nicholas J. "Structural studies of integrin activation." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:caf0f76f-b05a-4b72-8394-5f24de3fd5df.

Full text

Abstract:

Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that link the extracellular matrix to the actin cytoskeleton. Uniquely, these adhesion receptors mediate inside-out signal transduction, whereby extracellular adhesion is activated from within the cell by talin, a large cytoskeletal protein that binds to the cytoplasmic tail of the β integrin subunit via its PTB-like F3 domain. Features of the interface between talin1 and small β3 fragments only have been described previously. Through NMR studies of full-length integrin β tails, we have found that β tails differ widely in their interactions with different talin isoforms. The muscle-specific β1D/talin2 complex exhibited particularly high affinity, leading to the X-ray crystal structure of the β1D tail/talin2 F2-F3 complex. Further NMR and biological experiments demonstrated that integrin activation is induced by a concerted series of interactions between the talin F3 domain and the β tail and between the talin F2 domain and the cell membrane. Additional studies revealed the structural determinants of tight talin2/β1D binding and the basis of more general differences between β1 and β3 talin binding. NMR studies were also performed on tyrosine-phosphorylated integrin tails binding to the PTB domains of talin1 and Dok1, an inhibitor of integrin activation; these revealed that phosphorylation can inhibit integrin activation by increasing the affinity of the β tail for talin competitors. Key residues governing this switch were identified, and proteins were engineered with reversed affinities, offering potentially useful biological tools. Taken together, these results reveal the remarkable complexity of structural features that enable talin and its competitors to mediate this important form of transmembrane signalling.

APA, Harvard, Vancouver, ISO, and other styles

33

Mullan, C. L. "Structural studies of Ionic Liquids." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527876.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Brennan, Damian Frederick. "Structural studies of MAPK signalling." Thesis, Institute of Cancer Research (University Of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511162.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Malkova, Barbora. "Structural studies of cytoplasmic dynein." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540206.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Ball, L. J. "Structural studies of transcriptional regulators." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596318.

Full text

Abstract:

Both of the proteins studied in this work are involved in the control of gene expression at the transcriptional level. The first project described in this thesis involves the elucidation of the precise zinc co-ordination in the native zinc form of the PPR1 DNA-binding domain. PPR1 is a transcriptional activator found in the yeast, Saccharomyces cerevisiae, which specifically binds DNA in order to activate a series of genes involved in pyrimidine biosynthesis. The zinc-binding domain of PPR1 is highly conserved across a large number of yeast transcriptional activators and is important for the recognition of the palindromic CGG-(N)_n-CCG DNA sequence to which these proteins bind (where n is the number of nucleotides (N) which separate the CGG triplets). EXAFS spectroscopy revealed that each zinc atom in the cluster was co-ordinated by four cysteinyl sulphur atoms in a two-metal ion cluster. The sulphur ligands were at distances of 2.28 A and 2.41 A from the zinc, indicating terminal and bridging sulphurs, respectively, and the directly measured Zn-Zn separation was 3.16 A. Preliminary nuclear magnetic resonance (NMR) spectroscopic studies were also carried out on the same fragment in the hope that the structure of the PPR1 linker and dimerization domains, responsible for sequence specificity, could also be elucidated from these studies, but the NMR spectra were not of sufficient quality to allow a structure determination. The second project concentrates on the structure determination of the N-terminal domain of the mouse modifier protein, MoMOD1, which contains a highly conserved region known as the 'chromo' domain. The chromo domains are thought to be indirectly involved in modification of chromatin structure, by directing other proteins to particular sites on chromatin.

APA, Harvard, Vancouver, ISO, and other styles

37

Leath, Kirstin J. "Structural Studies of Complement Regulators." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526076.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

O'Connell, M. J. "Structural studies in alicyclic systems." Thesis, University of Canterbury. Chemistry, 1987. http://hdl.handle.net/10092/7252.

Full text

Abstract:

The crystal structures of exo- (22) and endo- (23) adducts of tetracyclone and cyclopentadiene have been determined and the relative orientations of the four phenyl rings shown to be similar in the two structures. The reactions between hemicyclone and a number of substituted benzoquinones gave a series of Diels-Alder adducts. Photolysis of the adducts gave derivatives of (21) and/or (29) other reactions of the parent compound with various reagents were studied. The X-ray crystal structures of oxetane (29) and cyanohydrin (55) were determined. The reactions of the diene (37) with twenty-two dienophiles have been studied and the stereochemistry of the products have been determined by crystallographic or spectroscopic means. With olefinic dienophiles reaction occurs exclusively by attack on the carbonyl-bearing face of the diene component of (37), whilst other dienophiles (benzyne, azo compounds and acetylenes) exhibit mixed π-facial selectivity. The origin of the mixed stereoselectivities is discussed. The X-ray crystal structures of the diene (62) and four Diels-Alder adducts (87), (90), (101) and (102) are discussed. The Diels-Alder reactions between cyclopentadiene and a number of substituted benzoquinones gave a series of adducts. Reduction of these adducts and reactionwith organometallic reagents were investigated. One- and two-dimensional n.m.r. analyses of selected products are discussed.

APA, Harvard, Vancouver, ISO, and other styles

39

Shum, Kwok-yan Daisy, and 岑國欣. "Structural studies on urinary glycosaminoglycans." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31230933.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Hunt, James. "Structural studies of immunoglobulin E." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/structural-studies-of-immunoglobulin-e(251aec27-5e3a-4ce5-9fbe-9493d158129d).html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Smith, Linda J. "Structural studies of adsorbed proteins." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320864.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Briggs, David Christopher. "Structural studies of bacterial toxins." Thesis, Birkbeck (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414899.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Walas, Fabien Patrick. "Structural studies of multidrug transporters." Thesis, Birkbeck (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425356.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Picken, Nichola Caryl. "Structural studies of porphobilinogen deaminase." Thesis, Birkbeck (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314290.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Hodgson, Susan Marie. "Structural studies of lithium compounds." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244863.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Yewdall, S. J. "Structural studies of Beta-lactoglobulin." Thesis, University of Leeds, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233792.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Turnbull, Andrew Paul. "Structural studies on leucine dehydrogenase." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245693.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Fawcett, Ian D. "Structural studies of disordered molybdates." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320188.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Moroz, Olga. "Structural studies on human S100A12." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403963.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Done, Sarah Helen. "Structural studies of penicillin acylase." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481793.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic 'Structural studies'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles