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Relevant bibliographies by topics / Structural Insights

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Academic literature on the topic 'Structural Insights'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "Structural Insights"

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Yates, Darran. "Structural insights." Nature Reviews Neuroscience 22, no. 4 (March 5, 2021): 195. http://dx.doi.org/10.1038/s41583-021-00453-9.

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Gross, Michael. "New structural insights." Current Biology 19, no. 16 (August 2009): R669—R670. http://dx.doi.org/10.1016/j.cub.2009.08.003.

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Kuppuraj, Gopi, Fumiko Suzuki, Masahiko Ikeuchi, and Kei Yura. "3P050 Structural insights into enzyme-bound flavin adenine dinucleotides (FAD)(01A. Protein: Structure,Poster)." Seibutsu Butsuri 53, supplement1-2 (2013): S220. http://dx.doi.org/10.2142/biophys.53.s220_2.

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Calderon-Villalobos, L. I., X. Tan, N. Zheng, and M. Estelle. "Auxin Perception--Structural Insights." Cold Spring Harbor Perspectives in Biology 2, no. 7 (May 26, 2010): a005546. http://dx.doi.org/10.1101/cshperspect.a005546.

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Fogg, Christiana N. "Structural insights into RSV." Science 359, no. 6381 (March 15, 2018): 1227.21–1229. http://dx.doi.org/10.1126/science.359.6381.1227-u.

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Ma, Xiaolei, Nazish Sayed, Annie Beuve, and Focco van den Akker. "Structural insights into sGC." BMC Pharmacology 7, Suppl 1 (2007): S37. http://dx.doi.org/10.1186/1471-2210-7-s1-s37.

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Mainstone, Rowland J. "Structural Analysis, Structural Insights, and Historical Interpretation." Journal of the Society of Architectural Historians 56, no. 3 (September 1997): 316–40. http://dx.doi.org/10.2307/991244.

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Tafur, Lucas, Jennifer Kefauver, and Robbie Loewith. "Structural Insights into TOR Signaling." Genes 11, no. 8 (August 4, 2020): 885. http://dx.doi.org/10.3390/genes11080885.

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The Target of Rapamycin (TOR) is a highly conserved serine/threonine protein kinase that performs essential roles in the control of cellular growth and metabolism. TOR acts in two distinct multiprotein complexes, TORC1 and TORC2 (mTORC1 and mTORC2 in humans), which maintain different aspects of cellular homeostasis and orchestrate the cellular responses to diverse environmental challenges. Interest in understanding TOR signaling is further motivated by observations that link aberrant TOR signaling to a variety of diseases, ranging from epilepsy to cancer. In the last few years, driven in large part by recent advances in cryo-electron microscopy, there has been an explosion of available structures of (m)TORC1 and its regulators, as well as several (m)TORC2 structures, derived from both yeast and mammals. In this review, we highlight and summarize the main findings from these reports and discuss both the fascinating and unexpected molecular biology revealed and how this knowledge will potentially contribute to new therapeutic strategies to manipulate signaling through these clinically relevant pathways.

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Zhang, Jin, Sizhuo Chen, and Ke Liu. "Structural insights into piRNA biogenesis." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1865, no. 2 (February 2022): 194799. http://dx.doi.org/10.1016/j.bbagrm.2022.194799.

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Li, Yaxin, Guopeng Wang, Ningning Li, Yuxin Wang, Qinyu Zhu, Huarui Chu, Wenjun Wu, et al. "Structural insights into immunoglobulin M." Science 367, no. 6481 (February 6, 2020): 1014–17. http://dx.doi.org/10.1126/science.aaz5425.

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Immunoglobulin M (IgM) plays a pivotal role in both humoral and mucosal immunity. Its assembly and transport depend on the joining chain (J-chain) and the polymeric immunoglobulin receptor (pIgR), but the underlying molecular mechanisms of these processes are unclear. We report a cryo–electron microscopy structure of the Fc region of human IgM in complex with the J-chain and pIgR ectodomain. The IgM-Fc pentamer is formed asymmetrically, resembling a hexagon with a missing triangle. The tailpieces of IgM-Fc pack into an amyloid-like structure to stabilize the pentamer. The J-chain caps the tailpiece assembly and bridges the interaction between IgM-Fc and the polymeric immunoglobulin receptor, which undergoes a large conformational change to engage the IgM-J complex. These results provide a structural basis for the function of IgM.

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Dissertations / Theses on the topic "Structural Insights"

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Gibson, Robert Patrick. "Structural insights into trehalose biosynthesis." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423843.

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Teo, Hsiang Ling. "Structural insights into ESCRT complexes." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614102.

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Busam, Robert Durstberger. "Exonuclease I : structural and biochemical insights/." view abstract or download file of text, 2005. http://wwwlib.umi.com/cr/uoregon/fullcit?p3190508.

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Thesis (Ph. D.)--University of Oregon, 2005.
Typescript. Includes vita and abstract. Includes bibliographical references (leaves 83-89). Also available for download via the World Wide Web; free to University of Oregon users.

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McManus, Edward. "Structural insights into lipoate protein ligases." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614075.

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Hunt, James. "Adhesion GPCRs : structural insights into receptor coupling." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590267.

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G-protein coupled receptors (GPCRs) are a diverse superfamily of membrane proteins. They have a wide range of physiological roles and include many successful drug targets. Sequencing of the human genome has revealed a distinct subfamily of GPCRs known as Adhesion GPCRs. These receptors possess unusually large extracellular N-terminal domains which are believed to be involved in cell-cell adhesion. Few data are available which demonstrate that these receptors are able to couple to G-proteins, their classification as GPCRs is primarily based on homology and predicted topology. These receptors are also mainly orphans. This investigation aims to demonstrate G-protein coupling of Adhesion GPCR members and use this coupling to aid de-orphanisation and pharmacological targeting. In this study, a selection of Adhesion GPCRs are expressed in a range of yeast (S. cerevisiae) strains each harbouring different mammalian-yeast chimeric G-proteins. Constitutive coupling of four different Adhesion GPCRs to the chimeric G-proteins is observed via a reporter gene assay. The chimeric G-proteins used represent the human complement, allowing prediction of the G-protein specificities of these receptors. This yeast assay is then used for high throughput screening to identify both potentially native ligands and inhibitors/potential therapeutic compounds. Following analysis in yeast, the Adhesion GPCRs CD97 and EMR2 were expressed in mammalian HEK293 cells where they also displayed constitutive activity when co-expressed with the appropriate Go. subunits (GaJ6).This constitutive activity is strong and mirrors the G-protein specificities seen in yeast. Using this assay, the effects of candidate CD97 and EMR2 ligands were assessed, their putative binding sites

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James, Nathan Rhys. "Structural insights into noncanonical mechanisms of translation." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267783.

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Translation is the process by which proteins are synthesized from the instructions in the genetic code. Translation is mediated by the ribosome, a large ribonucleoprotein complex, in concert with messenger RNA (mRNA), transfer RNA (tRNA), and a variety of proteins. The canonical mechanism of translation, introduced in Part I of my thesis, is divided into four distinct phases: initiation, elongation, termination, and recycling. Under unusual circumstances, each phase of translation can also proceed via a number of noncanonical mechanisms, many of which are vitally important for cellular growth or viral infectivity. My thesis describes structural insights into two such noncanonical mechanisms. The aim of the first project, described in Part II, was to structurally characterize a noncanonical mechanism of translational termination in bacteria. In the absence of a stop codon, ribosomes arrest at the 3′ end of an mRNA and are unable to terminate. In bacteria, the primary mechanism for rescuing such nonstop complexes is known as trans-translation. In the absence of a functional trans-translation system, however, the small protein ArfA recognizes the empty mRNA channel and recruits the release factor RF2 to the ribosome, enabling termination to occur. Using single-particle electron cryomicroscopy (cryo-EM), I obtained four high-resolution structures of nonstop complexes that reveal the mechanism of ArfA-mediated ribosome rescue and have wider implications for understanding canonical termination in bacteria. The aim of the second project, described in Part III, was to gain structural insights into a noncanonical mechanism of translational initiation in eukaryotes known as internal ribosome entry. Instead of a 5′ cap, many viruses contain intricately structured, cis-acting internal-ribosome-entry sites (IRESs) within their genomes that direct end-independent initiation. The IRES of hepatitis-C virus (HCV), for example, interacts directly with the mammalian ribosome and functionally replaces many of the canonical initiation factors. However, the mechanism by which the HCV IRES coordinates assembly of an initiation complex and progresses through the initiation phase remains poorly understood. I developed a method for purifying native ribosomal complexes from cell lysate that enabled me to obtain multiple cryo-EM maps of the HCV IRES in complex with the 80S ribosome, including a previously unseen conformation of the IRES induced by rotation of the ribosomal small subunit, and to make progress towards capturing earlier steps in the initiation pathway.

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Cash, Jennifer N. "Structural and Biochemical Insights into Myostatin Regulation." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1313697112.

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Santiago, Cuéllar Julia. "Structural insights into ABA perception and signalling: structure of ABA receptor PYR1." Doctoral thesis, Universitat Politècnica de València, 2011. http://hdl.handle.net/10251/13260.

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La sequía y la salinidad representan estreses ambientales que afectan de forma crítica el crecimiento de las plantas y limitan enormemente su potencial agrícola. La fitohormona ácido abcísico (ABA) juega un papel fundamental en la coordinación de la respuesta y adaptación de las plantas a este tipo de estreses, así como en la regulación del crecimiento y desarrollo vegetal. Elementos intermediarios de la ruta de señalización ya habían sido caracterizados, pero aún se desconocía el mecanismo de percepción y transducción de señal de la hormona. Este trabajo de tesis ha contribuido a la caracterización de una nueva familia de receptores intracelulares de la hormona ABA, formada por 14 miembros y denominada PYR/PYL (de pyrabactin resistance / PYR1-like) /RCAR (de Regulatory Component of Abscisic acid Receptor), y a su caracterización estructural y bioquímica. Estas proteínas son capaces de unir de forma específica la hormona ABA. La unión de la hormona induce en estos receptores un cambio conformacional, que les permite regular la actividad de los reguladores negativos de la ruta: fosfatasas del grupo A como ABI1, ABI2 o HAB1 ( Leung et al., 1994; Meyer et al.,1994; Saez et al., 2004). Para la caracterización de estos receptores se han llevado a cabo abordajes genéticos, bioquímicos, de calorimetría y estudios estructurales.
Santiago Cuéllar, J. (2011). Structural insights into ABA perception and signalling: structure of ABA receptor PYR1 [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/13260
Palancia

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Lau, Kelvin. "Binding and structural insights of the ryanodine receptor." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50503.

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Ryanodine Receptors (RyR) are large ion channels that are responsible for the release of Ca²⁺ from the sarco/endoplasmic reticulum. The channel consists of a large cytosolic cap which functions as a giant allosteric protein, capable of being modulated by an assortment of binding partners and small molecules. To understand its function and mechanisms one needs to dissect the channel to its smallest parts. Using a combination of isothermal titration calorimetry and x-ray crystallography, two areas have been analyzed: binding by calmodulin (CaM) and the structure of a RyR domain, SPRY2. Calmodulin (CaM) is a Ca²⁺ binding protein that can regulate RyR under conditions of both high and low Ca²⁺ by tuning their Ca²⁺ sensitivity to channel opening and closing in an isoform-specific manner. I analyze the binding of CaM and its individual domains to three different RyR CaM binding regions using isothermal titration calorimetry. I compared binding to skeletal muscle (RyR1) and cardiac (RyR2) isoforms, under both Ca²⁺-loaded and Ca²⁺ free conditions. I find that CaM is able to bind all three regions, but with different binding modes, between the isoforms. Disease mutations target one of the three sites and affect CaM binding and energetics. The SPRY2 domain is one of three repeats of the same fold that are present within the RyR. It has been suggested as a key protein interaction site with dihydropyridine receptors to mediate excitation-contraction coupling in skeletal muscle tissue. RyR1 and RyR2 SPRY2 domains were crystallized and reveal differences with several other known SPRY domain structures. Docking of the RyR1 SPRY2 structure places it in between the central rim and the clamp region. The structure of a disease mutant causing cardiomyopathy is also determined and shows local misfolding. Finally, RyR1 SPRY2 binding to the DHPR II-III loops is undetectable by isothermal titration calorimetry.
Medicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate

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Velloso, Lucas Malard. "Structural insights into glycoprotein transport and viral escape /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-780-0/.

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Books on the topic "Structural Insights"

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A, Nieuwland D., and Geological Society of London, eds. New insights into structural interpretation and modelling. London: Geological Society, 2003.

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service), SpringerLink (Online, ed. Tubulin-binding agents: Synthetic, structural and mechanistic insights. Berlin: Springer, 2009.

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Pegoretti, Alessandro. Adhesive Joining of Structural Components: New Insights and Technologies. Warrendale, PA: SAE International, 2018. http://dx.doi.org/10.4271/pt-191.

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Chao, Mao-Hsun. New insights into structural properties of incommensurate inclusion compounds. Birmingham: University of Birmingham, 2003.

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The clause structure of Wolof: Insights into the left periphery. Amsterdam: John Benjamins Pub. Co., 2013.

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Structural and Climatic Effects of Large-Scale Basaltic Magmatism: Constraints and Insights from Geodynamic Models. [New York, N.Y.?]: [publisher not identified], 2021.

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The dynamics of change: Insights into organisational transition from the natural world. London: Routledge, 1998.

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Patton, Wright G., ed. New ideas about new ideas: Insights on creativity from the world's leading innovators. Cambridge, MA: Perseus Publishing, 2002.

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White, Shira P. New ideas about new ideas: Insights on creativity from the world's leading innovators. Cambridge, MA: Perseus Pub., 2002.

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Local Structural Insights into Exotic Electronic States in 𝓭- and 𝑓-Electron Oxides with Joint Neutron and X-ray Pair Distribution Function Analysis. [New York, N.Y.?]: [publisher not identified], 2021.

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Book chapters on the topic "Structural Insights"

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Mahtaney, Piya. "Insights and Lessons from East Asia’s Economic Experience." In Structural Transformation, 63–84. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4662-8_4.

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Lapusta, Nadia. "Mechanics of Earthquake Source Processes: Insights from Numerical Modeling." In Structural Integrity, 156–58. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21894-2_30.

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Schneider, W. J. "The LDL Receptor — Structural Insights." In Receptor-Mediated Uptake in the Liver, 6–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70956-2_2.

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Serysheva, Irina I., Mariah R. Baker, and Guizhen Fan. "Structural Insights into IP3R Function." In Advances in Experimental Medicine and Biology, 121–47. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55858-5_6.

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Rodríguez, Javier M., and Daniel Luque. "Structural Insights into Rotavirus Entry." In Advances in Experimental Medicine and Biology, 45–68. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14741-9_3.

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Kruse, Andrew. "Structural Insights into Sigma1 Function." In Sigma Proteins: Evolution of the Concept of Sigma Receptors, 13–25. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/164_2016_95.

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Mahtaney, Piya. "The Link Between Productivity and Economic Progress: Issues and Insights." In Structural Transformation, 17–37. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4662-8_2.

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Röhe, Oke, and Nikolai Stähler. "Coordinated Structural Reforms: Insights from Fiscal and Labour Market Reforms in Germany." In Structural Reforms, 221–37. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-74400-1_10.

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Jacquinot, Pascal, Simon Savsek, Máté Tóth, and Igor Vetlov. "Structural Reforms at the Effective Lower Bound: Insights from the EAGLE Model." In Structural Reforms, 127–46. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-74400-1_6.

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Stein, Penelope E., Bart Hazes, and Randy J. Read. "Structural Insights into Pertussis Toxin Action." In Protein Toxin Structure, 191–216. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-22352-9_10.

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Conference papers on the topic "Structural Insights"

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Garland-Kuntz, Elisabeth, Kadidia Samassekou, Isaac J. Fisher, Kaushik Muralidharan, Abigail Gick, Morgan Laskowski, Emmanuel Oluwarotimi, et al. "Structural Insights into Phospholipase Ce." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.247650.

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Heeg, Jennifer, and Earl Dowell. "Aerodynamic and aeroelastic insights using eigenanalysis." In 40th Structures, Structural Dynamics, and Materials Conference and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1999. http://dx.doi.org/10.2514/6.1999-1472.

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NITZSCHE, F. "Insights on the whirl-flutter phenomena of advanced turboprops and propfans." In 30th Structures, Structural Dynamics and Materials Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1989. http://dx.doi.org/10.2514/6.1989-1235.

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Wolf, Sharon. "Structural and Chemical insights with CryoSTEM tomography." In European Microscopy Congress 2020. Royal Microscopical Society, 2021. http://dx.doi.org/10.22443/rms.emc2020.345.

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Simanshu, Dhirendra K. "Abstract IA02: New structural insights into KRAS biology." In Abstracts: AACR Special Conference on Targeting RAS-Driven Cancers; December 9-12, 2018; San Diego, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3125.ras18-ia02.

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Rahhal, Muhsin, and Dona Zakhem. "NEW INSIGHTS IN THE LIQUEFACTION POTENTIAL EVALUATION METHODS FOR SOILS." In 6th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering Methods in Structural Dynamics and Earthquake Engineering. Athens: Institute of Structural Analysis and Antiseismic Research School of Civil Engineering National Technical University of Athens (NTUA) Greece, 2017. http://dx.doi.org/10.7712/120117.5478.18171.

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Fan, Rong, and Michael S. Sacks. "Implementation and Validation of Planar Soft Tissue Structural Constitutive Model." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14809.

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Constitutive modeling is of fundamental important for numerical simulation and analysis of soft biological tissues. The mechanical behaviors of soft tissues are usually highly nonlinear and anisotropic. The complex behavior is the results from the interaction of tissue microstructure. By incorporating information of fiber orientation and distribution at tissue microscopic scale, the structural model avoids ambiguities in material characterization. Moreover, structural models produce much more information than just simple stress-strain results, but can provide much insight into how soft tissues internally reorganize to external loads by adjusting their internal microstructure. Moreover, it is only through simulation of an entire organ system can such information be derived and provide insight into physiological function. However, accurate implementation and rigorous validation of these models remains very limited. In the present study we implemented a structural constitutive model into a commercial finite element package. The structural model was verified against experiential test data for native bovine pericardium and fetal membrane. In addition to prediction of the mechanical response, we demonstrate how a structural model can provide deeper insights into fiber reorientation and fiber recruitment.

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Polymeni, A., and J. Underhill. "New Insights into the Structural Evolution of the Central Mediterranean." In 77th EAGE Conference and Exhibition 2015. Netherlands: EAGE Publications BV, 2015. http://dx.doi.org/10.3997/2214-4609.201413094.

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Bhattacharjee, Surjyendu, Uri Ryb, John M. Eiler, and Paul D. Asimow. "Structural and Isotopic Reordering in Magnesite: Insights from Heating Experiments." In Goldschmidt2020. Geochemical Society, 2020. http://dx.doi.org/10.46427/gold2020.184.

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Rossello, E. A., V. A. Nevistic, L. Pina, C. P. Bordarampé, and C. Colo. "Structural Concepts Supporting Frontier Exploration in the AndeanFoothills – New Insights." In 67th EAGE Conference & Exhibition. European Association of Geoscientists & Engineers, 2005. http://dx.doi.org/10.3997/2214-4609-pdb.1.p284.

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Reports on the topic "Structural Insights"

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Akim, Al-mouksit, and Wissal Sahel. Structural change and the National Initiative for Human Development in Morocco: Subnational insights. UNU-WIDER, June 2023. http://dx.doi.org/10.35188/unu-wider/2023/382-6.

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Greene, Geoffrey. Multidomain Assembly of Nuclear Estrogen Receptors: Structural Insights into ER-Positive Breast Cancer Therapeutics. Fort Belvoir, VA: Defense Technical Information Center, April 2012. http://dx.doi.org/10.21236/ada562255.

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Salomaa, Maria, and David Charles. The university third mission and the European Structural Funds in peripheral regions: insights from Finland. Center for Higher Education Policy Studies (CHEPS), 2019. http://dx.doi.org/10.3990/4.2535-5686.2019.07.

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Greene, Geoffrey. Multi-Domain Assembly of Nuclear Estrogen Receptors: Structural Insights into ER-Positive Breast Cancer Therapeutics. Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada580416.

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Castonguay, S., J. R. Dietrich, C. Morin, and J. Y. Laliberté. Structural architecture of the St. Lawrence platform and Quebec Appalachians: insights from reprocessed (MNRQ) seismic reflection data. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2001. http://dx.doi.org/10.4095/212973.

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Oswald, W., B. Dubé, S. Castonguay, V. McNicoll, J. Biczok, P. Mercier-Langevin, M. Malo, and T. Skulski. New insights on the structural and geological setting of the world-class Musselwhite gold deposit, Superior Province, northwestern Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2014. http://dx.doi.org/10.4095/294817.

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Honsberger, I. W., W. Bleeker, S L Kamo, H. A. I. Sandeman, and D. T W Evans. The emerging Paleozoic gold district of central Newfoundland: new insights on structural controls and tectonic drivers of gold mineralization and preservation. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2020. http://dx.doi.org/10.4095/326024.

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Galindo Paliza, Luis Miguel, Bridget Hoffmann, and Adrien Vogt-Schilb. Research Insights: How Much Will It Cost to Achieve the Climate Goals in Latin America and the Caribbean? Inter-American Development Bank, August 2022. http://dx.doi.org/10.18235/0004334.

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Meeting the climate change challenge requires structural transformations in infrastructure, health and social protection, and financial institutions. Climate action calls for a redirection of existing financial flows. An adequate response requires redirecting financial flows to achieve annual spending of 2 to 8 percent of GDP on the provision of infrastructure services and 5 to 11 percent of GDP on social programs. Specific financing sources, such as green taxes and sustainable bonds, can finance part of climate efforts. However, to redirect public and private spending and foreign investment into solutions consistent with climate goals, governments will also need to reform policies and regulations in all sectors.

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Oswald, W., S. Castonguay, B. Dubé, M. Malo, P. Mercier-Langevin, and J. Biczok. New insights on the geological and structural settings of the Musselwhite banded iron-formation-hosted gold deposit, North Caribou greenstone belt, Superior Province, Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2015. http://dx.doi.org/10.4095/295570.

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Patel, Reena. Complex network analysis for early detection of failure mechanisms in resilient bio-structures. Engineer Research and Development Center (U.S.), June 2021. http://dx.doi.org/10.21079/11681/41042.

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Abstract:

Bio-structures owe their remarkable mechanical properties to their hierarchical geometrical arrangement as well as heterogeneous material properties. This dissertation presents an integrated, interdisciplinary approach that employs computational mechanics combined with flow network analysis to gain fundamental insights into the failure mechanisms of high performance, light-weight, structured composites by examining the stress flow patterns formed in the nascent stages of loading for the rostrum of the paddlefish. The data required for the flow network analysis was generated from the finite element analysis of the rostrum. The flow network was weighted based on the parameter of interest, which is stress in the current study. The changing kinematics of the structural system was provided as input to the algorithm that computes the minimum-cut of the flow network. The proposed approach was verified using two classical problems three- and four-point bending of a simply-supported concrete beam. The current study also addresses the methodology used to prepare data in an appropriate format for a seamless transition from finite element binary database files to the abstract mathematical domain needed for the network flow analysis. A robust, platform-independent procedure was developed that efficiently handles the large datasets produced by the finite element simulations. Results from computational mechanics using Abaqus and complex network analysis are presented.

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