Journal articles on the topic 'Structural edit'
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Garcia-Hernandez, Carlos, Alberto Fernández, and Francesc Serratosa. "Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening." Current Topics in Medicinal Chemistry 20, no. 18 (August 24, 2020): 1582–92. http://dx.doi.org/10.2174/1568026620666200603122000.
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Background: Graph edit distance is a methodology used to solve error-tolerant graph matching. This methodology estimates a distance between two graphs by determining the minimum number of modifications required to transform one graph into the other. These modifications, known as edit operations, have an edit cost associated that has to be determined depending on the problem. Objective: This study focuses on the use of optimization techniques in order to learn the edit costs used when comparing graphs by means of the graph edit distance. Methods: Graphs represent reduced structural representations of molecules using pharmacophore-type node descriptions to encode the relevant molecular properties. This reduction technique is known as extended reduced graphs. The screening and statistical tools available on the ligand-based virtual screening benchmarking platform and the RDKit were used. Results: In the experiments, the graph edit distance using learned costs performed better or equally good than using predefined costs. This is exemplified with six publicly available datasets: DUD-E, MUV, GLL&GDD, CAPST, NRLiSt BDB, and ULS-UDS. Conclusion: This study shows that the graph edit distance along with learned edit costs is useful to identify bioactivity similarities in a structurally diverse group of molecules. Furthermore, the target-specific edit costs might provide useful structure-activity information for future drug-design efforts.
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Akande, Olanrewaju, Andrés Barrientos, and Jerome P. Reiter. "Simultaneous Edit and Imputation For Household Data with Structural Zeros." Journal of Survey Statistics and Methodology 7, no. 4 (December 24, 2018): 498–519. http://dx.doi.org/10.1093/jssam/smy022.
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Abstract Multivariate categorical data nested within households often include reported values that fail edit constraints—for example, a participating household reports a child’s age as older than his biological parent’s age—and have missing values. Generally, agencies prefer datasets to be free from erroneous or missing values before analyzing them or disseminating them to secondary data users. We present a model-based engine for editing and imputation of household data based on a Bayesian hierarchical model that includes (i) a nested data Dirichlet process mixture of products of multinomial distributions as the model for the true latent values of the data, truncated to allow only households that satisfy all edit constraints, (ii) a model for the location of errors, and (iii) a reporting model for the observed responses in error. The approach propagates uncertainty due to unknown locations of errors and missing values, generates plausible datasets that satisfy all edit constraints, and can preserve multivariate relationships within and across individuals in the same household. We illustrate the approach using data from the 2012 American Community Survey.
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Neuhaus, Michel, and Horst Bunke. "Edit distance-based kernel functions for structural pattern classification." Pattern Recognition 39, no. 10 (October 2006): 1852–63. http://dx.doi.org/10.1016/j.patcog.2006.04.012.
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HIDOVIĆ, DŽENA, and MARCELLO PELILLO. "METRICS FOR ATTRIBUTED GRAPHS BASED ON THE MAXIMAL SIMILARITY COMMON SUBGRAPH." International Journal of Pattern Recognition and Artificial Intelligence 18, no. 03 (May 2004): 299–313. http://dx.doi.org/10.1142/s0218001404003216.
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Two distance measures for attributed graphs are presented that are based on the maximal similarity common subgraph of two graphs. They are generalizations of two existing distance measures based on the maximal common subgraph. The new measures are superior to the well-known measures based on elementary edit transformations in that no particular edit operations (together with their costs) need to be defined. Moreover, they can deal not only with structural distortions, but also with perturbations of attributes. It is shown that the new distance measures are metrics.
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Rico-Juan, Juan R., Jose J. Valero-Mas, and José M. Iñesta. "Bounding Edit Distance for similarity-based sequence classification on Structural Pattern Recognition." Applied Soft Computing 97 (December 2020): 106778. http://dx.doi.org/10.1016/j.asoc.2020.106778.
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Rica, Elena, Susana Álvarez, and Francesc Serratosa. "Ligand-Based Virtual Screening Based on the Graph Edit Distance." International Journal of Molecular Sciences 22, no. 23 (November 25, 2021): 12751. http://dx.doi.org/10.3390/ijms222312751.
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Chemical compounds can be represented as attributed graphs. An attributed graph is a mathematical model of an object composed of two types of representations: nodes and edges. Nodes are individual components, and edges are relations between these components. In this case, pharmacophore-type node descriptions are represented by nodes and chemical bounds by edges. If we want to obtain the bioactivity dissimilarity between two chemical compounds, a distance between attributed graphs can be used. The Graph Edit Distance allows computing this distance, and it is defined as the cost of transforming one graph into another. Nevertheless, to define this dissimilarity, the transformation cost must be properly tuned. The aim of this paper is to analyse the structural-based screening methods to verify the quality of the Harper transformation costs proposal and to present an algorithm to learn these transformation costs such that the bioactivity dissimilarity is properly defined in a ligand-based virtual screening application. The goodness of the dissimilarity is represented by the classification accuracy. Six publicly available datasets—CAPST, DUD-E, GLL&GDD, NRLiSt-BDB, MUV and ULS-UDS—have been used to validate our methodology and show that with our learned costs, we obtain the highest ratios in identifying the bioactivity similarity in a structurally diverse group of molecules.
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Pinhas, Tamar, Shay Zakov, Dekel Tsur, and Michal Ziv-Ukelson. "Efficient edit distance with duplications and contractions." Algorithms for Molecular Biology 8, no. 1 (2013): 27. http://dx.doi.org/10.1186/1748-7188-8-27.
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Riesen, Kaspar, Andreas Fischer, and Horst Bunke. "Estimating Graph Edit Distance Using Lower and Upper Bounds of Bipartite Approximations." International Journal of Pattern Recognition and Artificial Intelligence 29, no. 02 (February 27, 2015): 1550011. http://dx.doi.org/10.1142/s0218001415500111.
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The concept of graph edit distance (GED) is still one of the most flexible and powerful graph matching approaches available. Yet, exact computation of GED can be solved in exponential time complexity only. A previously introduced approximation framework reduces the computation of GED to an instance of a linear sum assignment problem. Major benefit of this reduction is that an optimal assignment of nodes (including local structures) can be computed in polynomial time. Given this assignment an approximate value of GED can be immediately derived. Yet, this approach considers local — rather than the global — structural properties of the graphs only, and thus GED derived from the optimal node assignment generally overestimates the true edit distance. Recently, it has been shown how the existing approximation framework can be exploited to additionally derive a lower bound of the exact edit distance without any additional computations. In this paper we make use of regression analysis in order to predict the exact GED using these two bounds. In an experimental evaluation on diverse graph data sets we empirically verify the gain of distance accuracy of the estimated GEDs compared to both bounds.
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Strug, Joanna, and Barbara Strug. "Using Structural Similarity to Classify Tests in Mutation Testing." Applied Mechanics and Materials 378 (August 2013): 546–51. http://dx.doi.org/10.4028/www.scientific.net/amm.378.546.
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Mutation testing is an effective technique for assessing quality of tests provided for a system. However it suffers from high computational cost of executing mutants of the system. In this paper a method of classifying such mutants is proposed. This classification is based on using an edit distance kernel and k-NN classifier. Using the results of this classification it is possible to predict whether a mutant would be detected by tests or not. Thus the application of the approach can help to lower the number of mutants that have to be executed and so also to lower the cost of using the mutation testing.
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YAMAMOTO, YOSHIYUKI, KOUICHI HIRATA, and TETSUJI KUBOYAMA. "TRACTABLE AND INTRACTABLE VARIATIONS OF UNORDERED TREE EDIT DISTANCE." International Journal of Foundations of Computer Science 25, no. 03 (April 2014): 307–29. http://dx.doi.org/10.1142/s0129054114500154.
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In this paper, we investigate the problem of computing structural sensitive variations of an unordered tree edit distance. First, we focus on the variations tractable by the algorithms including the submodule of a network algorithm, either the minimum cost maximum flow algorithm or the maximum weighted bipartite matching algorithm. Then, we show that both network algorithms are replaceable, and hence the time complexity of computing these variations can be reduced to O(nmd) time, where n is the number of nodes in a tree, m is the number of nodes in another tree and d is the minimum degree of given two trees. Next, we show that the problem of computing the bottom-up distance is MAX SNP-hard. Note that the well-known linear-time algorithm for the bottom-up distance designed by Valiente (2001) computes just a bottom-up indel (insertion-deletion) distance allowing no substitutions.
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Finch, Andrew M., Richard C. Wilson, and Edwin R. Hancock. "An Energy Function and Continuous Edit Process for Graph Matching." Neural Computation 10, no. 7 (October 1, 1998): 1873–94. http://dx.doi.org/10.1162/089976698300017188.
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The contributions of this article are twofold. First, we develop a new nonquadratic energy function for graph matching. The starting point is a recently reported mixture model that gauges relational consistency using a series of exponential functions of the Hamming distances between graph neighborhoods. We compute the effective neighborhood potentials associated with the mixture model by identifying the single probability function of zero Kullback divergence. This new energy function is simply a weighted sum of graph Hamming distances. The second contribution is to locate matches by graduated assignment. Rather than solving the meanfield saddle-point equations, which are intractable for our nonquadratic energy function, we apply the soft-assign ansatz to the derivatives of our energy function. Here we introduce a novel departure from the standard graduated assignment formulation of graph matching by allowing the connection strengths of the data graph to update themselves. The aim is to provide a means by which the structure of the data graph can be updated so as to rectify structural errors. The method is evaluated experimentally and is shown to outperform its quadratic counterpart.
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Pecori, Riccardo, and Nina F. Papavasiliou. "It takes two (and some distance) to tango: how ADARs join to edit RNA." Nature Structural & Molecular Biology 27, no. 4 (March 27, 2020): 308–10. http://dx.doi.org/10.1038/s41594-020-0411-y.
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Beltran, Juan F., Xiaohua Liu, Nishant Mohanchandra, and Godfried T. Toussaint. "Measuring Musical Rhythm Similarity: Statistical Features Versus Transformation Methods." International Journal of Pattern Recognition and Artificial Intelligence 29, no. 02 (February 27, 2015): 1550009. http://dx.doi.org/10.1142/s0218001415500093.
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Two approaches to measuring the similarity between symbolically notated musical rhythms are compared with each other and with human judgments of perceived similarity. The first is the edit-distance, a popular transformation method, applied to the symbolic rhythm sequences. The second approach employs the histograms of the inter-onset-intervals (IOIs) calculated from the rhythms. Furthermore, two methods for dealing with the histograms are also compared. The first utilizes the Mallows distance, a transformation method akin to the Earth-Movers distance popular in computer vision, and the second extracts a group of standard statistical features, used in music information retrieval, from the IOI-histograms. The measures are compared using four contrastive musical rhythm data sets by means of statistical Mantel tests that compute correlation coefficients between the various dissimilarity matrices. The results provide evidence from the aural domain, that transformation methods such as the edit distance are superior to feature-based methods for predicting human judgments of similarity. The evidence also supports the hypothesis that IOI-histogram-based methods are better than music-theoretical structural features computed from the rhythms themselves, provided that the rhythms do not share identical IOI histograms.
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Klusch, Matthias, Patrick Kapahnke, and Ingo Zinnikus. "Adaptive Hybrid Semantic Selection of SAWSDL Services with SAWSDL-MX2." International Journal on Semantic Web and Information Systems 6, no. 4 (October 2010): 1–26. http://dx.doi.org/10.4018/jswis.2010100101.
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In this paper, the authors present an adaptive, hybrid semantic matchmaker for SAWSDL services, called SAWSDL-MX2. It determines three types of semantic matching of an advertised service with a requested one, which are described in standard SAWSDL: logic-based, text-similarity-based and XML-tree edit-based structural similarity. Before selection, SAWSDL-MX2 learns the optimal aggregation of these different matching degrees off-line over a random subset of a given SAWSDL service retrieval test collection by exploiting a binary support vector machine-based classifier with ranking. The authors present a comparative evaluation of the retrieval performance of SAWSDL-MX2.
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Simpkin, Adam J., Martyn D. Winn, Daniel J. Rigden, and Ronan M. Keegan. "Redeployment of automated MrBUMP search-model identification for map fitting in cryo-EM." Acta Crystallographica Section D Structural Biology 77, no. 11 (October 20, 2021): 1378–85. http://dx.doi.org/10.1107/s2059798321009165.
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In crystallography, the phase problem can often be addressed by the careful preparation of molecular-replacement search models. This has led to the development of pipelines such as MrBUMP that can automatically identify homologous proteins from an input sequence and edit them to focus on the areas that are most conserved. Many of these approaches can be applied directly to cryo-EM to help discover, prepare and correctly place models (here called cryo-EM search models) into electrostatic potential maps. This can significantly reduce the amount of manual model building that is required for structure determination. Here, MrBUMP is repurposed to fit automatically obtained PDB-derived chains and domains into cryo-EM maps. MrBUMP was successfully able to identify and place cryo-EM search models across a range of resolutions. Methods such as map segmentation are also explored as potential routes to improved performance. Map segmentation was also found to improve the effectiveness of the pipeline for higher resolution (<8 Å) data sets.
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Arifin, Mohammad Nazir, and Daniel Siahaan. "Structural and Semantic Similarity Measurement of UML Use Case Diagram." Lontar Komputer : Jurnal Ilmiah Teknologi Informasi 11, no. 2 (July 13, 2020): 88. http://dx.doi.org/10.24843/lkjiti.2020.v11.i02.p03.
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Reusing software has several benefits ranging from reducing cost and risk, accelerating development, and its primary purposes are improving software quality. In the early stage of software development, reusing existing software artifacts may increase the benefit of reusing software because it uses mature artifacts from previous artifacts. One of software artifacts is diagram, and in order to assist the reusing diagram is to find the level of similarity of diagrams. This paper proposes a method for measuring the similarity of the use case diagram using structural and semantic aspects. For structural similarity measurement, Graph Edit Distance is used by transforming each factor and use case into a graph, while for semantic similarity measurement, WordNet, WuPalmer,and Levenshtein were used. The experimentation was conducted on ten datasets from variousprojects. The results of the method were compared with the results of assessments from experts.The measurement of agreement between experts and method was done by using Gwet’s AC1 andPearson correlation coefficient. Measurement results with Gwet’s AC1 diagram similarity are 0,60,which were categorized as “moderate" agreement and the result of measurement with Pearsonis 0.506 which means there is a significant correlation between experts and methods. The resultshowed that the proposed method can be used to find the similarity of the diagram, so finding andreuse of the diagram as a software component can be optimized.
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Sussman, Joel, and Jaime Prilusky. "Proteopedia: Bridging the Rift Between 3D Structure & Function of Biomacromolecules." Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C1388. http://dx.doi.org/10.1107/s2053273314086112.
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Proteopedia is a wiki web resource, http://proteopedia.org, which aids in understanding of the structure/function relationship of biomacromolecules. The `3D' images on each page are surrounded by descriptive text containing hyperlinks that change the appearance (view, representations, colors or labels) of the adjacent 3D structure to reflect the concept discussed in the text (see figure below). This makes the complex structural information readily accessible and comprehensible, even to non-structural biologists. Using Proteopedia, scientists and students can easily create descriptions of biomacromolecules linked to their 3D structure, e.g., a page on the way inhibitors block HIV Protease, http://proteopedia.org/w/HIV-1_protease. Pages can be viewed on computers and tablets via the molecular viewer JSmol. Content is being added by ~2,600 Proteopedia's users from more than 50 countries, in a dozen different languages, including Arabic, Russian & Chinese. Members of the scientific community are invited to request a Proteopedia user account, at no cost, to create and edit pages, see: http://proteopedia.org/w/Special:RequestAccount.
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Freeman, B., M. Badley, and G. Yielding. "The Fault Analysis Projection System (FAPS) - A new seismic interpretation and structural geological interpretation tool." Exploration Geophysics 20, no. 2 (1989): 1. http://dx.doi.org/10.1071/eg989001.
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Recent research has demonstrated that the displacement on faults varies in a systematic manner, both vertically and laterally. Contours of displacement on strike projections display ordered patterns for isolated normal faults, strike-slip faults and syn-sedimentary faults. Recognition of these ordered patterns forms the basis for a new seismic interpretation and structural/geological interpretation tool, enabling objective verification of fault correlation, identification of bad fault or horizon picks, and a better understanding of the overall kinematic framework. The Fault Analysis Projection System (FAPS) is a computerized implementation of this technique designed to run on UNIX-based workstations. The FAPS uses the X-windows graphics system which permits different elements of the interpretation/analysis to be viewed at the same time and is designed to make adjustments to interpretations a simple task. For example, an interpreter may work on a map in one window, a set of sections in another window, perform a graphics screen-edit on data in a third window and view the results of an analysis in a separate, fourth window.
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Pedersen, Peter L. "Biochemistry, 2nd edit., edited by Donald Voet and Judith G. Voet. New York: Wiley, 1995, 1392 pages, $86.95." Proteins: Structure, Function, and Genetics 23, no. 4 (December 1995): 613. http://dx.doi.org/10.1002/prot.340230421.
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Pederson, Pete. "Protein Methods, 2nd edit., by Daniel M. Bollag, Michael D. Rozycki, and Stuart J. Edelstein. New York: Wiley-Liss, Inc." Proteins: Structure, Function, and Genetics 28, no. 1 (May 1997): 140. http://dx.doi.org/10.1002/(sici)1097-0134(199705)28:1<140::aid-prot16>3.0.co;2-j.
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Gross, Michael L. "Changes in JASMS: Carol robinson to edit new critical insights feature and joe loo to serve as new associate editor for protein mass spectrometry." Journal of the American Society for Mass Spectrometry 19, no. 5 (May 2008): 627–28. http://dx.doi.org/10.1016/j.jasms.2008.03.001.
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Serratosa, Francesc. "A Methodology to Generate Attributed Graphs with a Bounded Graph Edit Distance for Graph-Matching Testing." International Journal of Pattern Recognition and Artificial Intelligence 32, no. 11 (July 24, 2018): 1850038. http://dx.doi.org/10.1142/s0218001418500386.
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This paper presents a methodology for generating pairs of attributed graphs with a lower and upper- bounded graph edit distance (GED). It is independent of the type of attributes on nodes and edges. The algorithm is composed of three steps: randomly generating a graph, generating another graph as a sub-graph of the first, and adding structural and semantic noise to both. These graphs, together with their bounded distances, can be used to manufacture synthetic databases of large graphs. The exact GED between large graphs cannot be obtained for runtime reasons since it has to be computed through an optimal algorithm with an exponential computational cost. Through this database, we can test the behavior of the known or new sub-optimal error-tolerant graph-matching algorithms against a lower and an upper bound GED on large graphs, even though we do not have the true distance. It is not clear how the error induced by the use of sub-optimal algorithms grows with problem size. Thus, with this methodology, we can generate graph databases and analyze if the current assumption that we can extrapolate algorithms’ behavior from matching small graphs to large graphs is correct or not. We also show that with some restrictions, the methodology returns the optimal GED in a quadratic time and that it can also be used to generate graph databases to test exact sub-graph isomorphism algorithms.
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TSAY, YIH-TAY, and WEN-HSIANG TSAI. "MODEL-GUIDED ATTRIBUTED STRING MATCHING BY SPLIT-AND-MERGE FOR SHAPE RECOGNITION." International Journal of Pattern Recognition and Artificial Intelligence 03, no. 02 (June 1989): 159–79. http://dx.doi.org/10.1142/s0218001489000140.
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Due to noise and distortion, segmentation uncertainty is a key problem in structural pattern analysis. In this paper we propose the use of the split operation for shape recognition by attributed string matching. After illustrating the disadvantage of attributed string matching using the merge operation, the split operation is proposed. Under the guidance of the model shape, an input shape can be reapproximated, using the split operation, into a new attributed string representation. By combining the split and the merge operations for shape matching it is unnecessary to apply any type of edit operation to a model shape. This makes the distance between the input shape and the model shape more meaningful and stable, and improves recognition results. An algorithm for attributed string matching by split-and-merge is proposed. To eliminate the effect of the numbers of primitives in the model shape on the shape distance, shape recognition based on a similarity measure is also proposed. Good experimental results prove the feasibility of the proposed approach for general shape recognition.
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Fukagawa, Daiji, Takeyuki Tamura, Atsuhiro Takasu, Etsuji Tomita, and Tatsuya Akutsu. "A clique-based method for the edit distance between unordered trees and its application to analysis of glycan structures." BMC Bioinformatics 12, Suppl 1 (2011): S13. http://dx.doi.org/10.1186/1471-2105-12-s1-s13.
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Faghih Imani, Ahmadreza, Chris Harding, Siva Srikukenthiran, Eric J. Miller, and Khandker Nurul Habib. "Lessons from a Large-Scale Experiment on the Use of Smartphone Apps to Collect Travel Diary Data: The “City Logger” for the Greater Golden Horseshoe Area." Transportation Research Record: Journal of the Transportation Research Board 2674, no. 7 (June 9, 2020): 299–311. http://dx.doi.org/10.1177/0361198120921860.
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Smartphones offer a potential alternative to collect high-quality information on the travel patterns of individuals without burdening the respondents with reporting every detail of their travel. Smartphone apps have recently become a common tool for travel survey data collection around the world, especially for multiday surveys. However, there still exists a lack of systematic assessment of issues related to smartphone app-based surveys, such as the impact of app design or the recruitment method on the collected data. Through a large-scale experiment (named the City Logger), this paper assesses the data produced by the City Logger app, to better understand recruitment avenues (targeted invitation versus crowdsourcing), and examine differences in respondents’ travel behavior recruited through crowdsourcing methods. The paper also examines how app design, and particularly the user input method for trip validation, influences participants’ responses. The results indicate that, while crowdsourcing recruitment is promising, it might not yet be the best way to capture a true representation of the population. For app design, a combination of real-time and travel diary approaches is recommended. An ideal app would prompt users real-time and create a travel diary, so users can validate, edit, or delete the recorded information.
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Ji, Guangjun, Nannan Zhao, Xiaoyuan Zhou, Qian Wang, Yan Lu, and Zizhao Cai. "Study on the Method of Automatically Drawing Multiscale Engineering Geotechnical (Geological) Sections Step by Step of Engineering Layers including Lenses." Advances in Civil Engineering 2022 (March 12, 2022): 1–15. http://dx.doi.org/10.1155/2022/8696866.
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Drawing the engineering sections automatically and efficiently is significant for the investigation results of geotechnical engineering to provide the scientific and detailed geological basis for urban planning and construction, but it is still difficult to draw the engineering geological sections automatically without manual edit. A method, taking the engineering strata in Quaternary loose sedimentary as the research object, was proposed to automatically draw multiscale engineering geological sections of engineering layers including lenses and strata pinch-out based on the investigation results and borehole data of geotechnical (geological) engineering. Firstly, the spatial information of the top and bottom boundaries of any borehole layer were extracted, and then based on the stratigraphical column, the borehole layer was studied by a step-by-step coarsen from the finest stratigraphical column to the coarsest stratigraphical column, and the occupation relationship among layers was distinguished; secondly, from the coarsest stratigraphical column to the finest level stratigraphical column step-by-step and taking the radial basis function (RBF) interpolation as an example, top and bottom boundaries were interpolated, respectively, by following the order of current stratigraphical column; next, topological relationship among engineering layers was processed according to contact relationship of strata, and strata boundaries with 0 thickness were deleted; and finally, auxiliary information such as scaler and legend were added in section to complete the drawing of multiscale sections. Studies of one site case and one region case demonstrate that the method can perfectly and automatically draw the engineering geological section of engineering layers including lenses and strata pinch-out.
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Коваленко, С. А., Н. И. Гребенникова, В. А. Малиновкин, and П. С. Скочко. "DEVELOPMENT OF AN ELECTRONIC PLATFORM FOR ORGANIZING ONLINE EDUCATION WITH A COMPETENCE-BASED APPROACH." ВЕСТНИК ВОРОНЕЖСКОГО ГОСУДАРСТВЕННОГО ТЕХНИЧЕСКОГО УНИВЕРСИТЕТА, no. 3 (July 2, 2021): 25–31. http://dx.doi.org/10.36622/vstu.2021.17.3.004.
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Использование новейших технических разработок на базе созданных электронных платформ позволяет организовать качественное онлайн-образование. Сформулированы требования к разрабатываемой платформе обучения, такие как возможность создавать и редактировать курсы, возможность прикреплять методические материалы разных расширений и медиафайлы к курсу, возможность создавать и редактировать лекции / тесты в рамках курса, возможность проведения видеоконференций в рамках курса, возможность просмотра полной статистики результатов тестирования по курсу для преподавателей и её выгрузка, возможность двунаправленного общения преподавателя с обучающимися через чат. Созданное приложение реализует компетентностный подход. Включает рассмотрение структурной схемы курса. Сущность «Курс» может состоять из секций, которые, в свою очередь, могут состоять из подсекций (лекции, тесты, видеоконференция). Курс включает в себя всю информацию секций для обучения в рамках определенных компетенций. Представлена схема управления правами со стороны преподавателя. Рассмотрены жизненный цикл курса, интерфейс его создания и алгоритм прохождения курса, что дает полное представление о функциональных возможностях и особенностях работы программного обеспечения на созданной электронной платформе The use of the latest technical developments based on the created electronic platforms allows one to organize high-quality online education. In this article, we formulated the requirements for the developed training platform such as: the ability to create and edit courses, the ability to attach methodological materials of various extensions and media files to the course, the ability to create and edit lectures/tests within the course, the ability to conduct video conferences within the course, the ability to view full statistics of test results for the course for teachers and download it, the ability of bidirectional communication between the teacher and students via chat. The created application implements a competence-based approach. The article includes a review of the structural scheme of the course. The "Course" entity can consist of sections, which in turn can consist of subsections (lectures, tests, video conferences). The course includes all the information of the sections for training within certain competencies. The teacher's rights management scheme is also presented. We considered the life cycle of the course, the interface for its creation and the algorithm for passing the course, which gives a complete picture of the functionality and features of the software on the created electronic platform
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Yu, Ji Quan, Wan Tao Qian, and Xin Gang He. "Study on an Integrated Development Environment for PAC with Complete Intellectual Property." Applied Mechanics and Materials 135-136 (October 2011): 944–49. http://dx.doi.org/10.4028/www.scientific.net/amm.135-136.944.
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PAC(programmable automation controller) is a new trend of the industrial controller, but for now, most IDEs(integrated development environment) are still providing the PLC mode for users, which can not take full advantage of the PAC. Further more, in China, there is still not such IDE with complete intellectual properties for PACs designed by Chinese companies. For above purposes, the CHD-PACIDE was implemented which supported the ARM cortex-Mx series microcontrollers. This IDE consists of three layers, interface layer, data management layer and kernel layer, which managed functional modules respectively. Based on a C-like language Engineer C defined by our research team, the interface layer provided the structural graphical input mode and the text input mode for users to edit their code. The data management layer used the XML with specified format manage the flow of data. The kernel layer had two parts which were implemented in the IDE and the debug microcontroller stm8s, this layer can be used to debug user’s code through the Jtag port under the Coresight debugging structure of ARM. This IDE could be updated easily by adding the specific XML file for the new microcontroller used by the specific PAC.
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Westrip, Simon P. "publCIF: software for editing, validating and formatting crystallographic information files." Journal of Applied Crystallography 43, no. 4 (June 24, 2010): 920–25. http://dx.doi.org/10.1107/s0021889810022120.
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publCIFis an application designed for creating, editing and validating crystallographic information files (CIFs) that are used in journal publication. It validates syntax and dictionary-defined data attributes through internal routines, and also provides a web interface to thecheckCIFservice of the International Union of Crystallography (IUCr), which provides a full crystallographic analysis of the structural data. The graphical interface allows users to edit the CIF either in its `raw' ASCII form (using a text editor with context-sensitive data validation and input facilities) or as a formatted representation of a structure report (using a word-processing environment), as well asviaa number of convenience tools (e.g.spreadsheet representations of looped data). Beyond file and data validation,publCIFprovides access to resources to facilitate preparation of a structure report (e.g.databases of author details, experimental data, standard referencesetc., either distributed with the program or collected during its use), along with tools for reference parsing, spell checking, structure visualization and image management.publCIFwas commissioned by the IUCr, both as free software for authors and as a tool for in-house journal production; the tool for authors is described here. Binary distributions for Linux, MacOS and Windows operating systems are available.
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Valentim, Rodolfo Vieira, Giovanni Comarela, Souneil Park, and Diego Sáez-Trumper. "Tracking Knowledge Propagation Across Wikipedia Languages." Proceedings of the International AAAI Conference on Web and Social Media 15 (May 22, 2021): 1046–52. http://dx.doi.org/10.1609/icwsm.v15i1.18128.
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In this paper, we present a dataset of inter-language knowledge propagation in Wikipedia. Covering the entire 309 language editions and 33M articles, the dataset aims to track the full propagation history of Wikipedia concepts, and allow follow-up research on building predictive models of them. For this purpose, we align all the Wikipedia articles in a language-agnostic manner according to the concept they cover, which results in 13M propagation instances. To the best of our knowledge, this dataset is the first to explore the full inter-language propagation at a large scale. Together with the dataset, a holistic overview of the propagation and key insights about the underlying structural factors are provided to aid future research. For example, we find that although long cascades are unusual, the propagation tends to continue further once it reaches more than four language editions. We also find that the size of language editions is associated with the speed of propagation. We believe the dataset not only contributes to the prior literature on Wikipedia growth but also enables new use cases such as edit recommendation for addressing knowledge gaps, detection of disinformation, and cultural relationship analysis.
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Riba, Pau. "Distilling Structure from Imagery:Graph-based Models for the Interpretation of Document Images." ELCVIA Electronic Letters on Computer Vision and Image Analysis 19, no. 2 (January 12, 2021): 9–10. http://dx.doi.org/10.5565/rev/elcvia.1313.
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From its early stages, the community of Pattern Recognition and Computer Vision has considered the importance of leveraging the structural information when understanding images. Usually, graphs have been proposed as a suitable model to represent this kind of information due to their flexibility and representational power able to codify both, the components, objects, or entities and their pairwise relationship. Even though graphs have been successfully applied to a huge variety of tasks, as a result of their symbolic and relational nature, graphs have always suffered from some limitations compared to statistical approaches. Indeed, some trivial mathematical operations do not have an equivalence in the graph domain. For instance, in the core of many pattern recognition applications, there is a need to compare two objects. This operation, which is trivial when considering feature vectors defined in ℝn, is not properly defined for graphs. In this thesis, we have investigated the importance of the structural information from two perspectives, the traditional graph-based methods and the new advances on Geometric Deep Learning. On the one hand, we explore the problem of defining a graph representation and how to deal with it on a large scale and noisy scenario. On the other hand, Graph Neural Networks are proposed to first redefine a Graph Edit Distance methodologies as a metric learning problem, and second, to apply them in a real use case scenario for the detection of repetitive patterns which define tables in invoice documents. As experimental framework, we have validated the different methodological contributions in the domain of Document Image Analysis and Recognition.
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Ranjbaran, Seyed Mohsen, Azam Khan, Rayyan Manwar, and Kamran Avanaki. "Tutorial on Development of 3D Vasculature Digital Phantoms for Evaluation of Photoacoustic Image Reconstruction Algorithms." Photonics 9, no. 8 (July 31, 2022): 538. http://dx.doi.org/10.3390/photonics9080538.
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A synthetic phantom model is typically utilized to evaluate the initial performance of a photoacoustic image reconstruction algorithm. The characteristics of the phantom model (structural, optical, and acoustic) are required to be very similar to those of the biological tissue. Typically, generic two-dimensional shapes are used as imaging targets to calibrate reconstruction algorithms. However, these structures are not representative of complex biological tissue, and therefore the artifacts that exist in reconstructed images of biological tissue vasculature are ignored. Real data from 3D MRI/CT volumes can be extrapolated to create high-quality phantom models; however, these sometimes involve complicated pre-processing and mostly are challenging, due to the inaccessibility of these datasets or the requirement for approval to utilize the data. Therefore, it is necessary to develop a 3D tissue-mimicking phantom model consisting of different compartments with characteristics that can be easily modified. In this tutorial, we present an optimized development process of a generic 3D complex digital vasculature phantom model in Blender. The proposed workflow is such that an accurate and easily editable digital phantom can be developed. Other workflows for creating the same phantom will take much longer to set up and require more time to edit. We have made a few examples of editable 3D phantom models, which are publicly available to test and modify.
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Cervellino, Antonio, Ruggero Frison, Federica Bertolotti, and Antonietta Guagliardi. "DEBUSSY 2.0: the new release of a Debye user system for nanocrystalline and/or disordered materials." Journal of Applied Crystallography 48, no. 6 (November 28, 2015): 2026–32. http://dx.doi.org/10.1107/s1600576715020488.
Full textAbstract:
The new release ofDEBUSSYis introduced, a free open-source package devoted to the application of the Debye function analysis of powder diffraction data from nanocrystalline, defective and/or nonperiodic materials. The general strategy of the suite remains unchanged, following a two-step approach managed by theCLAUDEandDEBUSSYprograms, respectively. The first step essentially consists in generating a database where structural, size and shape information on a nanocrystal population is stored; the second step consists in the calculation, through the Debye scattering equation, of the total diffraction pattern using the previously generated database and a set of model parameters provided by the user and then optimized by the program. The novelties lie in the computational, modelling and graphical levels, and several new programs and features have been added. Among these are a new general comprehensive input file format (.ddb) for the database generation, the automatic management of the space-group symmetry and .cif file, new nanocrystal shapes, size-dependent site occupancy factors and thermal parameters for each atomic species, new lattice expansion functions, and a newly developed algorithm for calculating the standard errors of the optimized parameters. TheCLAUDEsuite also includes a program for calculation of the pair distribution function. Last but not least, a graphical user interface, which makes it easier to edit input files, execute the programs of the suite in a chain-like way, and plot the results in an automatic or custom manner, is provided.
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Mitrev, Rosen, Boris Tudjarov, and Todor Todorov. "CLOUD-BASED EXPERT SYSTEM FOR SYNTHESIS AND EVOLUTIONARY OPTIMIZATION OF PLANAR LINKAGES." Facta Universitatis, Series: Mechanical Engineering 16, no. 2 (August 1, 2018): 139. http://dx.doi.org/10.22190/fume180420016m.
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The present paper introduces a cloud-based expert system for synthesis and evolutionary optimization of planar linkages. The kinematic structure of the linkage is composed by the modular approach based on Assur’s groups. The dyads are represented as functional blocks with input and output variables. The applied approach for obtaining the geometrical relationships between the input and the output variables of the dyads is based on the use of homogeneous transformation matrices. The developed software system allows a dimensional synthesis of planar linkages by using genetic optimization algorithms. One feature is remote creation of the models of genetic algorithms as well as the receiving of the results by means of a user-friendly interface. By exploiting the application, the user can produce and edit the initial information about the synthesized or optimized linkage; thus he can receive the calculation results as a web page and/or as MS Excel file. An additional mutation of the best chromosome genes by scanning of every gene within its searching space improves the optimal solution. The analyzed numerical case studies show the applicability of the developed software system for mechanism analysis, synthesis and optimization. Because the number of genes is not limited, the linkages with a very big number of design variables can be synthesized by exploiting the developed approach.
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Akram, Fatima, Ikram ul Haq, Zeeshan Ahmed, Hamza Khan, and Muhammad Shrafat Ali. "CRISPR-Cas9, A Promising Therapeutic Tool for Cancer Therapy: A Review." Protein & Peptide Letters 27, no. 10 (November 2, 2020): 931–44. http://dx.doi.org/10.2174/0929866527666200407112432.
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Cancer is one of the most leading causes of mortality all over the world and remains a foremost social and economic burden. Mutations in the genome of individuals are taking place more frequently due to the excessive progress of xenobiotics and industrialization in the present world. With the progress in the field of molecular biology, it is possible to alter the genome and to observe the functional changes derived from genetic modulation using gene-editing technologies. Several therapies have been applied for the treatment of malignancy which affect the normal body cells; however, more effort is required to develop vsome latest therapeutic approaches for cancer biology and oncology exploiting these molecular biology advances. Recently, the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated protein 9 (Cas9) system has emerged as a powerful technology for cancer therapy because of its great accuracy and efficiency. Genome editing technologies have demonstrated a plethora of benefits to the biological sciences. CRISPR- Cas9, a versatile gene editing tool, has become a robust strategy for making alterations to the genome of organisms and a potent weapon in the arsenal of tumor treatment. It has revealed an excellent clinical potential for cancer therapy by discovering novel targets and has provided the researchers with the perception about how tumors respond to drug therapy. Stern efforts are in progress to enhance its efficiency of sequence specific targeting and consequently repressing offtarget effects. CRISPR-Cas9 uses specific proteins to convalesce mutations at genetic level. In CRISPR-Cas9 system, RNA-guided Cas9 endonuclease harnesses gene mutation, DNA deletion or insertion, transcriptional activation or repression, multiplex targeting only by manipulating 20-nucleotide components of RNA. Originally, CRISPR-Cas9 system was used by bacteria for their defense against different bacteriophages, and recently this system is receiving noteworthy appreciation due to its emerging role in the treatment of genetic disorders and carcinogenesis. CRISPR-Cas9 can be employed to promptly engineer oncolytic viruses and immune cells for cancer therapeutic applications. More notably, it has the ability to precisely edit genes not only in model organisms but also in human being that permits its use in therapeutic analysis. It also plays a significant role in the development of complete genomic libraries for cancer patients. In this review, we have highlighted the involvement of CRISPR-Cas9 system in cancer therapy accompanied by its prospective applications in various types of malignancy and cancer biology. In addition, some other conspicuous functions of this unique system have also been discussed beyond genome editing.
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Woelfle, Manuela, Till Seiler, Rosa Catera, Hartmut Dohner, Stephan Stilgenbauer, Steven L. Allen, Kanti R. Rai, Charles Chu, and Nicholas Chiorazzi. "Identification and Characterization of Peptide Ligands for Stereotyped Subset and Non-Subset B-Cell Receptors of Patients with M- and U-CLL." Blood 114, no. 22 (November 20, 2009): 4369. http://dx.doi.org/10.1182/blood.v114.22.4369.4369.
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Abstract Abstract 4369 In CLL, a disease with a variable and heterogeneous clinical course, a patient's prognosis depends on a series of factors including the mutation status of the IGHV gene. Both M-CLL, with a more favorable outcome, and U-CLL are derived from antigen-experienced B-cells. Clonal selection by antigen via the B-cell-receptor (BCR)/surface membrane immunoglobulin (smIg) is likely responsible for skewing IGHV repertoires of M- and U-CLL compared to normal B cells and to each other. Although there is abundant information about BCR structure in CLL, our knowledge of the antigens and epitopes reacting with the binding sites of these BCRs is limited. To identify and characterize actual or mimetic ligands to BCRs/Igs in CLL patients and to determine differences in epitope reactivity, phage-displayed peptide libraries were used. Recombinant IgG1 mAbs from 4 M-CLL and 4 U-CLL patients, expressed in human embryonic fibroblasts, were used to probe a 12-mer phage display peptide library using conditions that favor more specific and avid peptide-mAb interactions. Six of the mAbs studied belonged to the most frequent stereotypic subsets in CLL. Two M-CLL mAbs belonged to subset 2 and 4, and 4 U-CLL mAbs were representatives of subsets 1, 6, 8 and 9; patients within these subsets usually experience an aggressive disease with the exception of subset 4 patients with a more benign clinical course. Two M-CLL mAbs were not known to be part of a specific subset. After 3 rounds of selection, ligands were isolated for all 8 mAbs. Mimetic ligands from M-CLL and U-CLL mAbs showed significant differences. In general, peptides isolated by M-CLL mAbs were more similar to each other, exhibited better defined amino acid motifs, aligned more easily, and formed tighter clusters than U-CLL derived peptides. Probing with M-CLL mAbs yielded a large number of related and usually non-redundant peptides. These peptides contained approximately 6-8 identical or chemically-related amino acids that defined motifs. In contrast, peptides isolated by U-CLL mAbs did not display clear amino acid motifs. Pairwise alignment scores and edit distance showed a highly significant difference between peptides isolated with M-CLL and U-CLL mAbs (pairwise alignment score: P = 2×10-16, edit distance P = 3.76×10-20). Binding of individual phages to the selecting Igs was confirmed by enzyme immunoassay. Representative peptides for all M-CLL and U-CLL cases were synthesized and examined for binding to their selecting Igs and various other Igs from different IGHV subgroups. Mono-, oligo-, and poly-reactivity of peptides correlated with structural changes within antigen-binding sites of selecting M-CLL mAbs. Peptides isolated by M-CLL mAbs and certain U-CLL mAbs bound more effectively to the selecting mAb, although U-CLL-derived peptides were not as specific, reacting with M-CLL as well as U-CLL mAbs. For one M-CLL mAb, binding to target cells expressing a known natural ligand could be inhibited in a dose dependent manner. For another M-CLL mAb, binding to its homologous peptide could be blocked by the same peptide and not by a peptide isolated with a U-CLL mAb; this inhibition was also dose dependent. Collectively, our data suggest that somatic hypermutation that shapes the antigen-binding site influences the level of epitope specificity for an individual CLL BCR with M-CLL Igs having more specificity than U-CLL Igs. However, because of the clear cross-reactivity that exists for peptides isolated by U-CLL and certain M-CLL, structurally diverse epitopes could bind smIgs of distinct CLL clones in vivo and thereby alter survival and growth. Finally, peptides that bind to the BCR and/or inhibit smIg/mAb reactivity may represent therapeutic modalities in CLL. Disclosures: No relevant conflicts of interest to declare.
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Dionigi, Fabio, Zhenhua Zeng, Jing Zhu, Thomas Merzdorf, Malte Klingenhof, Wei-Xue Li, Jeffrey Greeley, and Peter Strasser. "Intrinsic Catalytic Activity and Active Phase for Oxygen Evolution in Layered Double Hydroxide Electrocatalysts." ECS Meeting Abstracts MA2022-02, no. 48 (October 9, 2022): 1870. http://dx.doi.org/10.1149/ma2022-02481870mtgabs.
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The NiFe layered double hydroxides (LDHs) are among the most active electrocatalysts for the oxygen evolution reaction (OER) in alkaline electrolytes.1 The incorporation of Fe dramatically increases the catalytic activity of Ni hydroxides.2 However, even the most active NiFe LDH catalyst still shows a considerable overpotential for the OER. Understanding the nature of the catalytic active sites and the catalytic mechanism are key challenges to develop better OER electrocatalysts. In this contribution, atomic-scale details of the catalytic active phase will be presented, showing that NiFe LDHs are oxidized under applied anodic potentials from as-prepared α-phases to activated γ-phases.3 The interlayer and in-plane lattice parameters of the OER-active γ-phase were obtained by performing wide angle X-ray scattering (WAXS) measurements on NiFe LDH nanoplatelets during operating electrochemical conditions and were characterized by a contraction of about 8%. Operando WAXS was then performed for other selected catalysts belonging to the transition metal LDH family of materials. Structural similarities of the catalytically active phases will be highlighted. Finally, in order to derive activity-structure relationships, an approach is presented to calculate intrinsic catalytic activities, which are challenging to evaluate for this class of materials. The presented method is based on electrochemical active surface area normalization obtained by impedance spectroscopy measurements under OER.4 References F. Dionigi and P. Strasser, Advanced Energy Materials, 2016, 6 1600621. L. Trotochaud, S. L. Young, J. K. Ranney and S. W. Boettcher, Journal of the American Chemical Society, 2014, 136: 6744-6753. F. Dionigi, Z. Zeng, I. Sinev, T. Merzdorf, S. Deshpande, M. B. Lopez, S. Kunze, I. Zegkinoglou, H. Sarodnik, D. Fan, A. Bergmann, J. Drnec, J. Ferreira de Araujo, M. Gliech, D. Teschner, J. Zhu, W.-X. Li, J. Greeley, B. Roldan Cuenya and P. Strasser, Nat Commun, 2020, 11 2522. F. Dionigi, J. Zhu, Z. Zeng, T. Merzdorf, H. Sarodnik, M. Gliech, L. Pan, W.-X. , Li, J. Greeley, and P. Strasser, Angew Chem Int Edit, 60, 14446 – 14457 (2021).
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Lin, Lee-kuo, Chih-chiang Chang, and Yu-cheng Lin. "STRUCTURE DEVELOPMENT AND PERFORMANCE EVALUATION OF CONSTRUCTION KNOWLEDGE MANAGEMENT SYSTEM / STATYBŲ ŽINIŲ VALDYMO SISTEMA: STRUKTŪROS KŪRIMAS IR EFEKTYVUMO ĮVERTINIMAS." Journal of Civil Engineering and Management 17, no. 2 (July 12, 2011): 184–96. http://dx.doi.org/10.3846/13923730.2011.576833.
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Construction or civil engineering is a kind of basic necessary industry for each citizen's livelihood. Due to its characteristic of participants and tasks variety, this industry becomes highly requirement for collaboration and professional knowledge. Applying knowledge management in construction industry can improve its’ operation with positive help. To illustrate the application effect and correct suitable management system, an appropriate evaluation model of performance result with constructional knowledge management system should be built. So this research uses Windows 2003 Server IIS Ver. 5.0 as the platform to develop a constructional knowledge management sharing system. Both end user and systematic function were integrated in this system. Meanwhile, this system applied three-tier structure and FrontPage to edit Web Server pages. This research also develops a performance evaluation model to check the application result of constructional knowledge management system. With the result of this research, the competition capability of construction industry could be increased. According to the main concept of this essay, the reference about performance evaluation will be collected at first. Then the current situation of internal construction knowledge management will be described. After that, scientific analysis including fuzzy Delphi method, fuzzy analytic hierarchy process (FAHP) and fuzzy theory will be used to develop an evaluation system of knowledge management performance. This model includes four levels: knowledge creation, knowl- edge transportation, knowledge spreading and knowledge accumulating. After developing and testing, the proof of knowledge manage the feasibility duct into the construction industry, organization decision ability and competitiveness in construction industry could be promoted through this system and to echo an objective of knowledge economy. Santrauka Statyba yra vienas iš pagrindinių būtinų pramonės sektorių, kuris yra svarbus kiekvienam gyventojui. Dėl dalyviams būdingų savybių ir užduočių įvairovės šiame sektoriuje labai svarbus bendradarbiavimas ir profesines žinios. Žinių vadyba gali pagerinti statybų sektoriaus veiklą. Norint pademonstruoti taikymo poveikį ir tinkamą valdymo sistemą, reikia sukurti tinkamą efektyvumo vertinimo modelį su statybos žinų valdymo sistema. Taigi šiame tyrime kaip platformą pasitelkus Windows 2003 Server IIS Ver. 5.0 buvo sukurta statybos žinių valdymo sistema. Šioje sistemoje integruoti ir galutiniai vartotojai, ir sisteminė funkcija. Sistemoje naudojama trijų lygių struktūra, o internetinio serverio puslapiams redaguoti naudota FrontPage. Šiame tyrime taip pat kuriamas efektyvumo vertinimo modelis, kurį naudojant patikrinami statybos žinių valdymo sistemos taikymo rezultatai. Taikant šio tyrimo rezultatus, galima padidinti statybų pramonės konkurencingumą. Remiantis pagrindine šio darbo idėja, pirmiausia surenkama literatūra apie efektyvumo vertinimą. Tuomet aprašoma esama vidinio statybos žinių valdymo situacija. O tuomet, pasitelkus mokslinę analizę, įskaitant neapibrėžtų aibių Delfi metodą, neapibrėžtų aibių analitinį hierarchijos procesą (FAHP) ir neapibrėžtų aibių teoriją, sukuriama žinių vadybos efektyvumo vertinimo sistema. Šis modelis turi keturis lygius: žinių kūrimo, žinių perdavimo, žinių platinimo ir žinių kaupimo. Sukūrus ir išbandžius šios sistemos galimybes statybos pramoneje, šią sistemą būtų galima naudoti norint pagerinti organizacijos gebėjimą priimti sprendimus ir konkurencingumą; tai atitiktų žinių ekonomikos tikslus.
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Dahlig, Piotr. "Oskar Kolberg (1814–1890) the Founder of Musical Ethnography in Poland." Musicology Today 11, no. 1 (December 1, 2014): 1–5. http://dx.doi.org/10.2478/muso-2014-0008.
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Abstract The article presents the greatest Polish ethnographer, who was also a professionally educated musician. He concentrated his activities on the oral musical culture, still vital in the 19th century but liable to changes. Culture studies by Kolberg concerned mainly rural communities, statistically dominating in those times. He planned to edit 60 volumes geographically covering the first Polish State from before 1772; he managed to print 33 of them in his lifetime and prepare many further anthologies for editing. Up till now, the editorial work is still in progress. The already edited 80 volumes show us an old social culture, folk ceremonies, musical repertoire including ritual singing, songs and instrumental pieces. Kolberg’s printed monument is a source of reflection on the past and can inspire social studies, ethnomusicological research as well as musical ensembles performing traditional ethnic music of peasant origin. The size of Kolberg’s documentation means that a special Institute of Oskar Kolberg had to be established to continue editorial and research work. In spite of his positivistic and empirical attitude, Kolberg still kept a romantic faith in the significance of folk songs and singing for the preservation of national components in cultural consciousness. Simultaneously, he developed a model for structural analysis of popular/folk culture and intended to build a cultural atlas of the country, building on the work of his father, professor of the University of Warsaw, an outstanding cartographer. But the core of Kolberg’s programme, its “planetary centre”, was always music. It was music that gave him the stimulus to interpret the culture of Central-Eastern Europe. To preserve regional diversity, he wrote down more than 20 thousand vocal melodies, song texts and instrumental pieces, paying special attention to variants and ornamentation. For the contemporary composer, Kolberg’s volumes are a useful musical reader. These huge anthologies of elementary but highly integrated musical concepts demonstrate the collective creativity and a fascinating prefiguration of mass culture, still open to symbols and to poetry. Kolberg’s music transcriptions, catching music in the process of performance, should not be treated as unchangeable patterns for copying, but rather as a source that helps understand creativity in traditional oral culture.
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الحوامدة, إيصال صالح. "عروض مختصرة." الفكر الإسلامي المعاصر (إسلامية المعرفة سابقا) 28, no. 103 (June 21, 2022): 285–301. http://dx.doi.org/10.35632/citj.v28i103.6213.
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من النبي ﷺ إلى البخاري دراسة في حركة رواية الحديث ونقده في القرون الثلاثة الأولى، أحمد عبد الجبار صنوبر، عمّان: دار الفتح للدراسات والنشر، ط1، 2022م، 448 صفحة. تحليل الخطاب القرآني- دراسة نقدية تطبيقية للمناهج الغربية المعاصرة، حمازة محمد الطاهر، إربد- الأردن: دار ركاز للنشر والتوزيع، ط1، 2021م، 615 صفحة. الغزالي وفلسفته الكلامية، فرانك غريفل، ترجمة: مريم شحاتة، بيروت: دار الروافد الثقافية، ط1، 2021م، 640 صفحة. النهضة في القرآن الكريم بناؤها ومقوماتها من خلال سورة الكهف، علي محمد أسمر، عمّان: جمعية المحافظة على القرآن الكريم، ط1، 2018م، 346 صفحة. العمارة والسياسة والتاريخ - المدينة الإسلامية في مغرب العصر الوسيط، مصطفى عرباوي، إربد-الأردن: عالم الكتب الحديث، ط1، 2020م، 330 صفحة. العمران فلسفة الحياة في الحضارة الإسلامية، خالد عزب، القاهرة: الدار المصرية اللبنانية، ط1، 2022م، 280 صفحة. علاقة الفكر الإصلاحي بمقاصد العقيدة ومقاصد الشريعة: محمد الطاهر ابن عاشور أنموذجاً، عثمان كضوار، عمّان: دار ركاز للنشر والتوزيع، ط1، 2021م، 395 صفحة. طرق معرفة مقاصد الشريعة وضوابط إعمالها في النظر الاجتهادي، محمد المنتار، بيروت: الرابطة المحمدية للعلماء، ط1، 2020م، 412 صفحة. تعدد المرجعية في ضوء مقاصد الشريعة الإسلامية، نور الدين الخادمي، لندن: مؤسسة الفرقان للتراث الإسلامي، ط1، 2020م، 452 صفحة. جدلية الحديث النبوي وعلم الكلام دراسة في مستويات الاتصال والانفصال، هدى فريد، القاهرة: مركز إحياء للبحوث والدراسات، ط1، 2021م، 912 صفحة. مقاصد الشريعة من التدوين إلى التقعيد، أبو القاسم بن أحمد إبراهيم مسملي، الدمام: دار ابن الجوزي، ط1، 2022م، 440 صفحة. الدليل النقلي في الفكر الكلامي، أحمد عبد الرحيم، الرياض: مركز تكوين للدراسات والأبحاث، 2019م، 504 صفحة. رؤى قرآنية في التجديد والسياسة والعمران، مجموعة مؤلفين، عمّان: دار ركاز للنشر والتوزيع، 2021م، 108 صفحة. رؤية العالم حضور وممارسات في الفكر والعلم والتعليم، فتحي حسن ملكاوي، فرجينيا-واشنطن: المعهد العالمي للفكر الإسلامي، 2021م، 448 صفحة. Revelation in the Qur’an: A Semantic Study of the Roots n-z-l and w-h-y, by Simon P. Loynes, Leiden: Brill Academic Pub, February 2021, 181 Structural Dividers in the Qur'an (Routledge Studies in the Qur'an), edit by Marianna Klar, London: Routledge, December 2020, 418 Text Linguistics of Qur'anic Discourse (Culture and Civilization in the Middle East), by Hussein Abdul-Raof, London: Routledge, December 2020, 382 pages Islamic Theology in the Turkish Republic (Edinburgh Studies on Modern Turkey) 1st Edition, by Philip Dorroll, Edinburgh: Edinburgh University Press, April 2021, 248 Shaping a Qur'anic Worldview: Scriptural Hermeneutics and the Rhetoric of Moral Reform in the Caliphate of al-Ma'un (Routledge Studies in the Qur'an), by Vanessa De Gifis, London: Routledge, December 2019, 142 pages The Oxford Handbook of Islamic Philosophy (Oxford Handbooks), Editing by Khaled El-Rouayheb & Sabine Schmidtke, Oxford: Oxford University Press, June 2019, 720 pages.
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López, Alberto Luis. "Ontología y mundo externo en Berkeley [Berkeley’s Ontology and External World]." LOGOS Revista de Filosofía 135, no. 135 (July 21, 2020): 11–23. http://dx.doi.org/10.26457/lrf.v135i135.2713.
Full textAbstract:
Es habitual que algunos lectores confundan la postura de Berkeley al creer que niega la existencia del mundo externo y que su filosofía lleva inevitablemente al solipsismo. Frente a estas lecturas, analizo en este artículo el tema de la relación entre ontología y mundo externo en Berkeley, con el propósito de aclarar algunos desaciertos interpretativos sobre el asunto y mostrar con ello tres cosas: 1) que se trata de un error creer que su filosofía elimina el mundo externo y lleva al solipsismo, 2) que en la propia ontología está la clave para entender la constitución del mundo externo, y 3) que Dios le da el sentido último a ese mundo.
Palabras clave
Berkeley, mundo externo, ontología, Dios, solipsismo
Referencias
Berkeley, G., Philosophical Commentaries, en: The Works of George Berkeley, Bishop of Cloyne, Luce, A. A. (ed.). London: Nelson & Sons Ltd., 1948-57, 9 vols. Vol. I, 1948.
___________, A Treatise Concerning the Principles of Human Knowledge; Three Dialogues Between Hylas and Philonous, en: The Works of George Berkeley, Bishop of Cloyne, Jessop, T. E. (ed.). London: Nelson & Sons Ltd., 1948-57, 9 vols. Vol. II, 1949.
___________, Alciphron or the Minute Philosopher, en: The Works of George Berkeley, Bishop of Cloyne, Jessop, T. E. (ed.). London: Nelson & Sons Ltd. 9 vols. 1948-57, 9 vols. Vol. III, 1950.
___________, Comentarios filosóficos. Introducción Manuscrita a los Principios del conocimiento humano. Correspondencia con Johnson. J. A. Robles (trad.). México: IIF’s-UNAM, 1989.
Bettcher, Talia Mae. Berkeley. A Guide for the Perplexed. Londres: Continuum, 2008.
Cassirer, Ernst. La Filosofía de las formas simbólicas. 3 vols. México: FCE, 1976.
Hight, M.A. (ed.). The Correspondence of George Berkeley. Nueva York: Cambridge University Press, 2013.
Liébana Martínez, Ismael, “Conocimiento y mundo externo en Berkeley”. Diálogo Filosófico nº 46 (enero/abril, 2000): 69-76.
Luis López, Alberto, “Berkeley: sobre el conocimiento nocional de la mente”, Contrastes. Revista Internacional de Filosofía 22, núm. 1, mayo (2017): 137-154.
___________, “Sobre la ontología inmaterialista: el concepto de idea en Berkeley”, Areté. Revista de Filosofía 31, núm. 2 (2019): 427-449.
Muehlmann, Robert G. “The Substance of Berkeley’s Philosophy”. En Berkeley´s Metaphysics: Structural, Interpretive, and Critical Essays, edit. Muehlmann, Robert, 89-105. University Park: Pennsylvania State University Press, 2004.
Nols, Carmen. Zeichenhafte Wirklichkeit. Realität als Ausdruck der kommunikativen Präsenz Gottes in der Theologie George Berkeleys. Tübingen: Mohr Siebeck, 2011.
Roberts, John Russell. A Metaphysics for the Mob. The Philosophy of George Berkeley. New York: Oxford University Press, 2007. Robles, José Antonio. “Inteligibilidad y cualidades sensibles: de Descartes a Berkeley o de la resurrección de las cualidades secundarias”. Diánoia XLIV, núm 44 (1998): 33-62.
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Yang, Guangwei, Elijah Paintsil, Ginger E. Dutschman, Susan P. Grill, Chuan-Jen Wang, Jimin Wang, Hiromichi Tanaka, Takayuki Hamasaki, Masanori Baba, and Yung-Chi Cheng. "Impact of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations P119S and T165A on 4′-Ethynylthymidine Analog Resistance Profile." Antimicrobial Agents and Chemotherapy 53, no. 11 (August 24, 2009): 4640–46. http://dx.doi.org/10.1128/aac.00686-09.
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ABSTRACT 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T), a derivative of stavudine (d4T), has potent activity against human immunodeficiency virus and is much less inhibitory to mitochondrial DNA synthesis and cell growth than its progenitor, d4T. 4′-Ed4T triphosphate was a better reverse transcriptase (RT) inhibitor than d4T triphosphate, due to the additional binding of the 4′-ethynyl group at a presumed hydrophobic pocket in the RT active site. Previous in vitro selection for 4′-Ed4T-resistant viral strains revealed M184V and P119S/T165A/M184V mutations on days 26 and 81, respectively; M184V and P119S/T165A/M184V conferred 3- and 130-fold resistance to 4′-Ed4T, respectively. We investigated the relative contributions of these mutations, engineered into the strain NL4-3 background, to drug resistance, RT activity, and viral growth. Viral variants with single RT mutations (P119S or T165A) did not show resistance to 4′-Ed4T; however, M184V and P119S/T165A/M184V conferred three- and fivefold resistance, respectively, compared with that of the wild-type virus. The P119S/M184V and T165A/M184V variants showed about fourfold resistance to 4′-Ed4T. The differences in the growth kinetics of the variants were not more than threefold. The purified RT of mutants with the P119S/M184V and T165A/M184V mutations were inhibited by 4′-Ed4TTP with 8- to 13-fold less efficiency than wild-type RT. M184V may be the primary resistance-associated mutation of 4′-Ed4T, and P119S and T165A are secondary mutations. On the basis of our findings and the results of structural modeling, a virus with a high degree of resistance to 4′-Ed4T (e.g., more than 50-fold resistance) will be difficult to develop. The previously observed 130-fold resistance of the virus with P119S/T165A/M184V to 4′-Ed4T may be partly due to mutations both in the RT sequence and outside the RT sequence.
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Niu, Xin, and Nick Menhart. "Structural Perturbations of Exon-Skipping Edits within the Dystrophin D20:24 Region." Biochemistry 60, no. 10 (March 3, 2021): 765–79. http://dx.doi.org/10.1021/acs.biochem.0c00827.
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Nitanda, Takao, Xin Wang, Hiroki Kumamoto, Kazuhiro Haraguchi, Hiromichi Tanaka, Yung-Chi Cheng, and Masanori Baba. "Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine In Vitro." Antimicrobial Agents and Chemotherapy 49, no. 8 (August 2005): 3355–60. http://dx.doi.org/10.1128/aac.49.8.3355-3360.2005.
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ABSTRACT 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine (4′-Ed4T) has been identified as a novel nucleoside analog with potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity and weak cytotoxicity in cell cultures. 4′-Ed4T proved to be 5- to 10-fold more active than its structurally related compound, stavudine (d4T). However, the drug resistance profile of 4′-Ed4T was different from those of d4T and other existing HIV-1 nucleoside reverse transcriptase inhibitors (NRTIs). Approximately 6- to 11-fold decreases in susceptibility to 4′-Ed4T were observed for HIV-1 carrying NRTI-associated mutations (D67N, K70R, T215F, and K219Q) or the lamivudine (3TC)-resistant mutation M184V. In contrast, the susceptibility of the virus carrying the K65R mutation or the multidrug-resistant mutation with the Q151M complex (A62V, V75I, F77L, F116Y, and Q151M) was not altered. Furthermore, the activity of 4′-Ed4T appeared to be enhanced in the presence of K103N, a major nonnucleoside reverse transcriptase inhibitor-resistant mutation. Although 4′-Ed4T was 4.5- to 17.5-fold less active against multidrug-resistant clinical isolates than against a reference strain isolated from a treatment-naïve patient, it was still inhibitory to these isolates at low concentrations. Analysis of 4′-Ed4T-resistant HIV-1 obtained through in vitro selection revealed that the virus was also resistant to 3TC and had two amino acid mutations (P119S and T165A) in addition to the M184V mutation. Since 4′-Ed4T has increased anti-HIV-1 activity, decreased cytotoxicity, and a different resistance profile, it should be considered for further development as a new member of NRTIs.
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Tiutina, Liubov. "NEWEST TRENDS IN ARCHITECTURE XXI CENTURY." Current problems of architecture and urban planning, no. 59 (March 1, 2021): 132–51. http://dx.doi.org/10.32347/2077-3455.2021.59.132-151.
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The article has been devoted to identifying and summarizing the main trends of architecture of the XXI century. Social development as well as scientific and technological progress form conditions for further development of architecture and the search for new materials and new design methods. Owing to the Industrial Revolution, the invention of construction technologies and other innovative things, a new structural scheme of buildings appeared at the beginning of the twentieth century. It was based on the enclosing structure of the building, which, unlike the architecture that existed before the twentieth century, no longer took on the load of floors – namely, it was not load-bearing. The main type and method of forming the appearance of the building was the curtain facade, which received a wide variety of expressions. This includes, both during the twentieth century and today, a wide range of applications in enclosing structures of more and more new synthetic materials, the display of various textures, textures, compositional techniques, color solutions, perforated surfaces etc. The materials and structures themselves can be very different: from translucent structures to sandwich-panels.
Since the beginning of the Industrial Revolution and throughout the twentieth century, the exploitation of Earth's Resources has led to devastating consequences and environmental disasters. This is reflected even in the economic and political plans of states. Therefore, since the middle of the twentieth century, the leading European countries have taken a course towards sustainable development. And, the XXI century is focused on improving the environment and energy saving. Such changes affect the formation of new techniques in architecture. The task of sustainable development forces the new forms as well as techniques and materials that will ensure the fulfillment of these requirements to be looked for. Such actions lead to the improvement of the curtain facade and saturation of its functional component. This is the manifestation of new trends and directions.
The economic factor can also be considered as an influential factor in the emergence of innovative techniques. The advertising and marketing industry pushes architects in their creative quest to design iconic, unusual buildings with dynamic know-how or media technologies. They become the hallmark of urban space. We are talking about Media Architecture and kinetics.
The present time is an era of high Information Technologies and their significant influence on the formation of the face of modern architecture. Nowadays, with the help of complex computer calculations, a parametric architecture of complex geometric shapes has appeared and the new design methods are being developed. With the help of virtual reality, one can both demonstrate objects, and directly design and edit the design of objects down to the smallest details.
Design has been increasingly capturing the architecture. 3-D construction methods can build architecture of any shape. This leads to the formation of objects that do not depend on the location.
Every year on the Internet the number of projects of space architecture – conceptual solutions for the colonization of Mars or the Moon increases. This is also part of the trend of replacing architecture with design.
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Wu, Ya-Ling, Eldon Y. Li, and Wei-Lun Chang. "Nurturing user creative performance in social media networks." Internet Research 26, no. 4 (August 1, 2016): 869–900. http://dx.doi.org/10.1108/intr-10-2014-0239.
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Purpose – Creative performance relies on the capability of developing and presenting an original concept or idea, and the collaborative production of creative content which enhances feeling of connection with others and formation of strong community. The purpose of this paper is to apply the theory of work performance containing four dimensions (capacity, opportunities, willingness, and performance) to investigate how the capabilities of social network sites enhance user creative performance through collective social capital and information capital (opportunities) for and individual habit of use (willingness) of the user to engage in social learning process. Design/methodology/approach – Many measurement items are adapted from the literature, except those measuring the constructs of social media capabilities (i.e. transmission velocity (TV), parallelism, symbol sets, rehearsability, and reprocessability) and user creative performance. The study uses survey method to collect data from social media network (SMN) users in Taiwan. Facebook is chosen as the source because it is the most prevalent and sophisticated social media platform that provides a home for users to interact and communicate. Structural equation modeling with partial least square is used to analyze the usable data collected from 533 Facebook users. Findings – The results show that the constructs are significantly and positively correlated, meaning that social media capabilities enable social capital, information capital, and habit of use to improve user creative performance in SMNs. Three out of five social media capabilities (i.e. TV, parallelism, and rehearsability) are identified as the key enablers. Research limitations/implications – Because of the sampled surveyed subjects and the single research method, there are some limitations in this study. The research results may lack generalizability that should be taken into account when they are interpreted. The authors encourage researchers to test the proposed theoretical model further with additional subjects, variables, and linkages. Practical implications – The findings of this research shed light for managers of SMN platforms on how to manage the platforms more effectively. A healthy SMN platform must implement at least these three media capabilities: the functions of news feed (i.e. TV), chat (i.e. parallelism), edit (i.e. rehearsability), in order to sustain its service. Social implications – This study confirmed that user creative performance can be increased in various ways through social capital, information capital, and habit of use. Company management should use SMNs (e.g. Facebook or Twitter) to enable employees to interact and exchange ideas and promote “coopetition” among employees across the company. If the organizational culture supports free expression of ideas and sharing of opinions, the development and robustness of group creativity can be enhanced, leading to higher competitive advantage for a company against its competitors. Originality/value – Past studies related to individual creativity have mostly discussed it as a personality trait or talent; yet, personality trait or talent is implicit until it is shown by one’s behavior. Thus, for the collective performance of user creativity on SMNs, the authors elicit individual creativity through the creative performance manifested by user behavior. Furthermore, the authors confirm that social capital, information capital, and habit of use are the critical antecedents of user creative performance, and that the five social media capabilities are the enablers of social capital, information capital, and habit of use on SMNs.
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Fedorova, Nadiia. "THE STRUCTURE OF THE TELEVISION FORMAT AND THE CHARACTERISTICS OF ITS ELEMENTS AS AN AUDIOVISUAL WORK." Theory and Practice of Intellectual Property, no. 1 (June 3, 2022): 28–34. http://dx.doi.org/10.33731/12022.258186.
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Key words: television format, elements of television format, audiovisual production, copyright, television format structure
The article reveals the issues regarding such a complex object of copyright as a television format. The television format is considered as a type of audiovisual work, its structure and characteristics of its elements are analyzed. The current legislation and judicial practice are reviewed, it is substantiated that the elements of the television format should be characterized by signs of originality, uniqueness, and singularity.
List of references:
1. Vakhonieieva T. Elements and procedure for the author's agreement conclusion. Theory and practice of intellectual property. 2016. No 5 (91). PP.18–28
2. Big explanatory dictionary of the modern Ukrainian language with app. and addit. / Chief Editor V. T. Busel. Kyiv, Irpin: VTF “Perun”, 2005. P. 939.
3. Halych O., Nazarets ., Vasyliev Ye. Theory of literature: textbook / by the scientific edition of О. Halych, 4th ed., stereotype. К.: Lybid, 2008. P. 144.
4. Ionas V. Ya. Criterion of creativity in copyright and jurisprudence / V. Ya. Ionas. Moscow: Juridical Literature, 1963. 140 p.
5. Kantorovych Ya.А. Copyright in Literary, Musical, Artistic and Photographic Works. SPb.: «Pravo», 2011. P. 105
6. Kyiashko Yu. Director's script as a plan for translating the author's intention into a television program / Yu. Кyiashko. KhNU Bulletin. 2011. No 3. PP. 59–62.
7. Literary encyclopedia: Dictionary of literary notions: in 2 v. / by the edit. of N. Brodskyi, A. Lavretskyi, E. Lunin, V. Lvov-Rohachevskyi, M.Rozanov, V. Cheshykhin-Vetrinskii. M.; L.: L. D. Frenkel Publishing House, 1925.
8. Maratkanova A. A. Format of an audiovisual work as a result of intellectual property. New Juridical Bulletin. 2020. No 2 (16). PP. 31–34. URL: http://moluch.ru/th/9/archive/156/4874 (access date 02.03.21.)
9. “On copyright and related rights» (as amended by Law No 212 from 29.07.2016): Law of Republic of Moldova No 139 dated 02 July, 2010. URL: http://www.wipo.int/wipolex/en/text.jsp?file_id=421473 (access date 13.07.21.)
10. On the application by the courts of the norms of legislation in cases on the protection of copyright and related rights: Resolution of the Plenum of the Supreme Court of Ukraine on 04 June, 2010 No 5. URL: https://zakon.rada.gov.ua/laws/show/v0005700-10#Text (access date 22.07.21.)
11. Stromov Yu.A. The path of an actor to creative reincarnation / Yu. А. Stromov. М., 1975. 80 p.
12. Fridmen V.E. Protection of parts and structural elements of a work as objects of copyright in Russia and the USA: abstract of dissertation for the degree of candidate of juridical sciences / Fridmen V.E., М., 2005.
13. Draft treaty on the protection of broadcasting organizations. Joint Proposal by the Delegations of South Africa and Mexico. Standing Committee on Copyright and Related Rights. 24th Session. Geneva, July 16 to 25, 2012. URL: http://www.wipo.int/edocs/mdocs/copyright/en/sccr_24/sccr_24_5.pdf (access dare 14.06.21).
14. European agreement on the protection of television broadcasts. Strasbourg, 22.VI.1960. URL: http: //conventions.coe.int/Treaty/EN/Treaties/Html/034.htm (access date 22.05.21).
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Schultheis, Ellen, Michael A. Dreger, Manfred Nimtz, Victor Wray, Dietmar C. Hempel, and Bernd Nörtemann. "Structural characterization of the exopolysaccharide PS-EDIV from Sphingomonas pituitosa strain DSM 13101." Applied Microbiology and Biotechnology 78, no. 6 (April 2008): 1017–24. http://dx.doi.org/10.1007/s00253-008-1383-8.
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Humay qızı Bayramlı, Aynur. "Structural semantic features of homonyms in English." SCIENTIFIC WORK 79, no. 6 (June 17, 2022): 185–90. http://dx.doi.org/10.36719/2663-4619/79/185-190.
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Məqalə ingilis dilində omonimlərin struktur-semantik xüsusiyyətlərinin öyrənilməsindən bəhs edir. Bu məqalədə omonimlik anlayışı verilir və omonimlərin təsnifatı, omonimlərin yaranmasının əsas səbəbləri, ingilis dilində omonimiyin xüsusiyyətləri nəzərdən keçirilir. Təhlil əsasında belə qənaət əldə edilir ki, omonimiya hadisəsi ingilis dilində kifayət qədər tez-tez rast gəlinən və çətin bir hadisədir və omonimlər də istənilən dili zənginləşdirə və bəzəyə bilir, belə tələffüz əsasında sözlərdən çoxlu sayda söz birləşmələri yaratmağa imkan verir. Açar sözlər: omonimlik, dilçilik, lüğət tərkibi, terminlər, söz formaları Aynur Humay Bayramlı Structural semantic features of homonyms in English Abstract The article deals with the study of structural- semantic features of homonyms in the English language. This article gives the concept of homonymy and considers the classification of homonyms, the main reasons for the appearance of homonyms, the features of homonymy in the English language . Based on the analysis, it is concluded that the phenomenon of homonymy is a fairly frequent and difficult phenomenon in the English language, and homonyms are also able to enrich and decorate any language, allow you to create a large number of puns based on such pronunciation of words. Key words: homonymy, linguistics, vocabulary, terms, word forms
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Edwards, Donna, Elizabeth Sierra Potchanant, Xinxin Huang, Zejin Sun, Maegan Capitano, Caroline Miller, Ying He, Hal E. Broxmeyer, and Grzegorz Nalepa. "Patient-Tailored Mouse Genome Editing Recapitulates Hematopoietic and Systemic Manifestations of Barth Syndrome." Blood 130, Suppl_1 (December 7, 2017): 775. http://dx.doi.org/10.1182/blood.v130.suppl_1.775.775.
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Abstract Barth syndrome (BTHS; OMIM# 302060) is an X-linked disorder of neutropenia, cardiomyopathy and muscular weakness due to mitochondrial dysfunction secondary to inherited tafazzin (TAZ) mutations. Neutropenia occurs in the majority of BTHS patients, leading to high risk of recurrent life-threatening bacterial infections. The etiology of the G-CSF-responsive neutropenia in BTHS is incompletely understood and appears to reflect impaired granulopoiesis. Long-term risk of myelodysplasia (MDS) in BTHS individuals requiring chronic G-CSF therapy is unknown due to the rarity of the disorder; further, genotype-phenotype correlations between the severity of neutropenia and TAZ mutations remain to be elucidated. Genetic Taz knockout is embryonic lethal in the mouse. Therefore, a genetic BTHS mouse model is urgently needed to improve our mechanistic understanding of this disease and develop clinical studies based on preclinical evidence. We employed CRISPR/Cas system to edit our BTHS patient's tafazzin point mutation (D75H) into the endogenous murine Taz gene. The resulting mice recapitulated hematopoietic and systemic manifestations of Barth syndrome. TazD75H males are born at less than expected Mendelian frequencies (p<0.0001) and suffer from perinatal lethality and failure to thrive with 69% decrease of body size at postnatal day 29 compared to age-matched wt males (p<0.0001). TazD75H males have neutropenia at 1 month of age evidenced by complete blood counts and independent manual peripheral smear analysis (p=0.04). Young TazD75H mice had mildly decreased bone marrow cellularity per femur (p=0.01675) accompanied by deficient functional bone marrow colony-forming ability compared to age- and sex-matched wt mice (approximately 3.5-fold decrease in CFU-GM, p=0.0002, and CFU-GEMM, p=0.0041), consistent with a functional hematopoietic defect. Similar to BTHS patients, TazD75H mice develop prenatal cardiomyopathy, with echocardiograms of surviving mice demonstrating left ventricular non-compaction (p=0.0339) and decreased ejection fraction (p=0.038). Further, TazD75H mice recapitulate the Barth syndrome phenotype of impaired skeletal muscle strength as shown by decreased ability to lift weights and perform hanging exercise (p=0.0072). Interestingly, TazD75H males developed infertility due to profound spermatogenesis arrest (p<0.0001). These data indicate that TazD75H mice recapitulate all crucial clinical findings in Barth syndrome. Given the role of tafazzin in mitochondrial cardiolipin metabolism, we examined the structure and function of mitochondria in TazD75H mice. Strikingly, transmission electron microscopy revealed accumulation of swollen mitochondria with fractured cristae in TazD75H hematopoietic cells, cardiomyocytes and skeletal muscle, reflecting the mitochondrial phenotype of BTHS patients. Total mitochondrial mass quantified by MitoTracker flow was unchanged in TazD75H hematopoietic cells, but flow cytometry using the JC-1 mitochondrial membrane potential probe revealed disrupted mitochondrial potential during live TazD75H hematopoiesis in multi-potential progenitors (MPPs, p=0.0025), Lin- Sca-1+ c-kit+ cells (p<0.0001), Lin- Sca-1- c-kit- (p=0.0036), lineage-negative (p<0.0001) and lineage-positive (p=0.0211) hematopoietic cells. Quantitative Seahorse metabolic profiling revealed impaired mitochondrial respiration in live TazD75H hematopoietic cells, confirming functional mitochondrial deficiency. In summary, our work demonstrates that impaired hematopoiesis in Barth syndrome, which is embryonic lethal in the mouse, can be recapitulated in vivo through editing a patient-specific hypomorphic tafazzin mutation into the murine genome. The precision-medicine TazD75H mouse model recapitulates clinical hallmarks of BTHS in hematopoietic and non-hematopoietic tissues, accompanied by structural and functional mitochondrial defects. This work enables in vivo studies to enhance our mechanistic understanding and treatment of hematopoetic and other defects in Barth syndrome. Figure Figure. Disclosures No relevant conflicts of interest to declare.