Academic literature on the topic 'Stroke; animal models; middle cerebral artery occlusion'
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Journal articles on the topic "Stroke; animal models; middle cerebral artery occlusion"
Golubev, A. M. "Models of Ischemic Stroke (Review)." General Reanimatology 16, no. 1 (March 2, 2020): 59–72. http://dx.doi.org/10.15360/1813-9779-2020-1-59-72.
Full textLiu, Fudong, and Louise D. McCullough. "Middle Cerebral Artery Occlusion Model in Rodents: Methods and Potential Pitfalls." Journal of Biomedicine and Biotechnology 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/464701.
Full textPercie du Sert, Nathalie, Alessio Alfieri, Stuart M. Allan, Hilary VO Carswell, Graeme A. Deuchar, Tracy D. Farr, Paul Flecknell, et al. "The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)." Journal of Cerebral Blood Flow & Metabolism 37, no. 11 (August 11, 2017): 3488–517. http://dx.doi.org/10.1177/0271678x17709185.
Full textMauler, Frank, and Ervin Horváth. "Neuroprotective Efficacy of Repinotan HCl, a 5-HT1A Receptor Agonist, in Animal Models of Stroke and Traumatic Brain Injury." Journal of Cerebral Blood Flow & Metabolism 25, no. 4 (January 26, 2005): 451–59. http://dx.doi.org/10.1038/sj.jcbfm.9600038.
Full textRamli, Yetty, Ahmad S. Alwahdy, Mohammad Kurniawan, Berry Juliandi, Puspita E. Wuyung, and Yayi D. B. Susanto. "Permanent flame-blunted monofilament of middle cerebral artery occlusion technique for ischemia stroke induction in animal models." Medical Journal of Indonesia 26, no. 3 (November 27, 2017): 183–9. http://dx.doi.org/10.13181/mji.v26i3.1645.
Full textBoltze, Johannes, Annette Förschler, Björn Nitzsche, Daniela Waldmin, Anke Hoffmann, Christiane M. Boltze, Antje Y. Dreyer, et al. "Permanent Middle Cerebral Artery Occlusion in Sheep: A Novel Large Animal Model of Focal Cerebral Ischemia." Journal of Cerebral Blood Flow & Metabolism 28, no. 12 (August 13, 2008): 1951–64. http://dx.doi.org/10.1038/jcbfm.2008.89.
Full textLeon, Rachel L., Xinlan Li, Jason D. Huber, and Charles L. Rosen. "Worsened Outcome from Middle Cerebral Artery Occlusion in Aged Rats Receiving 17β-Estradiol." Endocrinology 153, no. 7 (May 11, 2012): 3386–93. http://dx.doi.org/10.1210/en.2011-1859.
Full textKrueger, Martin, Wolfgang Härtig, Clara Frydrychowicz, Wolf C. Mueller, Andreas Reichenbach, Ingo Bechmann, and Dominik Michalski. "Stroke-induced blood–brain barrier breakdown along the vascular tree – No preferential affection of arteries in different animal models and in humans." Journal of Cerebral Blood Flow & Metabolism 37, no. 7 (October 1, 2016): 2539–54. http://dx.doi.org/10.1177/0271678x16670922.
Full textBrown, Aliza, Sean Woods, Robert Skinner, Jeff Hatton, John Lowery, Paula Roberson, Leah Hennings, and William C. Culp. "Neurological Assessment Scores in Rabbit Embolic Stroke Models." Open Neurology Journal 7, no. 1 (October 31, 2013): 38–43. http://dx.doi.org/10.2174/1874205x01307010038.
Full textRewell, Sarah SJ, John A. Fernandez, Susan F. Cox, Neil J. Spratt, Lisa Hogan, Elena Aleksoska, Leena van Raay, Gabriel T. Liberatore, Peter E. Batchelor, and David W. Howells. "Inducing Stroke in Aged, Hypertensive, Diabetic Rats." Journal of Cerebral Blood Flow & Metabolism 30, no. 4 (January 13, 2010): 729–33. http://dx.doi.org/10.1038/jcbfm.2009.273.
Full textDissertations / Theses on the topic "Stroke; animal models; middle cerebral artery occlusion"
Gharbawie, Omar A., and University of Lethbridge Faculty of Arts and Science. "Modeling middle cerebral artery stroke in rats : an examination of the skilled reaching impairments." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2006, 2006. http://hdl.handle.net/10133/388.
Full textxiii, 345 leaves : ill. ; 29 cm. + 1 CD-ROM
Wells, Adam James. "A surgical model of middle cerebral artery occlusive stroke in the sheep." Thesis, 2014. http://hdl.handle.net/2440/91277.
Full textThesis (Ph.D.) -- University of Adelaide, School of Medical Sciences, 2014
Che-Chuan, Wang, and 王哲川. "Therapeutic evaluation of agmatine in middle cerebral artery occlusion induced stroke animal model : the rule of aquaporin 4." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/01789995492031301378.
Full text南台科技大學
生物科技系
97
Cerebral edema contributes to morbidity and mortality in stroke. The regulation of water balance in the brain is crucial. A disruption in this equilibrium causes an increase in brain water content that significantly contributes to the pathophysiology of traumatic brain injury, hydrocephalus, and a variety of neurological disorders. The discovery of the aquaporin (AQP) family of membrane water channels has provided important new insights into the physiology and pathology of brain water homeostasis. A number of recent studies are described in the review that demonstrated the important role of AQP4 in brain water balance and cerebral edema. Agmatine is an endogenous clonidine-displacing substance, an agonist for the α-2-adrenergic and imidazoline receptors, and an antagonist at N-methyl-D-aspartate (NMDA) receptors. In the present study, we examined alterations in glial and neuronal cell responses to the reported neuroprotective action of agmatine against cerebral ischemia. Rats were randomly divided into three groups: sham operation group, middle cerebral artery occlusion (MCAo) with saline treatment group, and MCAo with agmatine (100 mg/kg body weight) treatment group. Adult Sprague-Dawley rats were given intraperitoneal injection of agmatine or saline immediately after 90 min occlusion of the middle cerebral artery. In all animals, regional cerebral blood flow (rCBF) were measured by laser-Doppler flowmetery with flexible probe fixed on the skull starting before onset of ischemia until 2 hours after reperfusion. Implanting an intracranial microdialysis probe was assessed the markers of cerebral ischemia and cellular injury (including glycerol, glutamate and lactate/pyruvate ratio) in brain. Focal cerebral ischemia (for 90 minutes) was induced by MCAo by introducing a 4-0 monofilament nylon suture, whose tip have been rounded by heating near a flame and coated with poly-L-lysine, were introduced from the carotid bifurcation into the internal carotid artery until a mild resistance were felt (18 to 19 mm), thereby occluding the origin of the MCA. We used immunohistochemistry and immunofluorescence staining to determine the levels of AQP-4, and iNOS at different time points (1hr, 3hrs, 48hr, and 72hours) after transient MCAo. Brain swelling were quantitated in dry/ wet ratio at the level of the ipsilateral hemisphere. The maximum grip angle in an inclined plane was measured to determine motor performance whereas the percent of maximal possible effect was used to measure blockade of proprioception. The triphenyltetrazolium chloride (TTC) staining procedures were used for cerebral infarction assay. Our results revealed that, after the onset of MCAo, the neuronal ischemia/ damage markers were all significantly increased. Similarly, the protein expression of iNOS and AQP-4, were all significantly elevated in the cortex, hippocampus, and striatum of rat brain after at 3days after reperfusion, and result in neuronal apoptosis, gliosis and locomotor dysfuction. Systemic treatment with agmatine significantly enhanced survival of glial cells at 3 days after reperfusion of the MCA, and the preservation of these glial cells in the ischemic brain corresponded with a markedly reduced area of infarction as well as increased neuronal survival. The ischemia-induced locomotor and proprioception deficits were partially ameliorated in agmatine-treated animals evaluated at 3 days after the reperfusion of the MCA. Immunohistological assays further demonstrated that agmatine treatment significantly reduced the overexpression of the iNOS and AQP-4 of the ischemic brains. These results suggest that agmatine may cause attenuation of cerebral infarction as well as motor deficits by enhancing glial cell and neuronal survival.
Book chapters on the topic "Stroke; animal models; middle cerebral artery occlusion"
Cam, Ertugrul, Ertugrul Kilic, Burak Yulug, and Marie-Françoise Ritz. "Occlusion of the Middle Cerebral Artery in Rats." In New Animal Models of Human Neurological Diseases, 52–65. Basel: KARGER, 2008. http://dx.doi.org/10.1159/000117723.
Full textOrsu, Prabhakar, and Y. Srihari. "Experimental Animal Models of Cerebral Ischemic Reperfusion Injury." In Preclinical Animal Modeling in Medicine. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.97592.
Full textWang-Fischer, Yanlin, and Lee Koetzner. "Surgery Procedure for Distal Middle Cerebral Artery Occlusion Model." In Manual of Stroke Models in Rats, 99–106. CRC Press, 2008. http://dx.doi.org/10.1201/9781420009521-12.
Full textWang-Fischer, Yanlin, and Lee Koetzner. "Surgery Procedure for Distal Middle Cerebral Artery Occlusion Model." In Manual of Stroke Models in Rats, 99–105. CRC Press, 2008. http://dx.doi.org/10.1201/9781420009521.ch12.
Full textGupta, Sangeetha, and Uma Sharma. "Intraluminal filament induced middle cerebral artery occlusion model of transient focal cerebral ischemia in rats." In Handbook of Animal Models in Neurological Disorders, 613–29. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-89833-1.00052-5.
Full textConference papers on the topic "Stroke; animal models; middle cerebral artery occlusion"
Hirschberg, M., A. Manoutchei, B. Klemens, and B. Hofferberth. "CEREBRAL THROMBOLYSIS WITH INTRAVENOUSLY ADMINISTERED RECOMBINANT LOW- MOLECULAR-WEIGHT-UROKINASE AND RECOMBINANT PRO-UROKINASE IN A DOG MODEL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643571.
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