Dissertations / Theses on the topic 'Stress suppression'
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Bridgett, Stephen John. "Detail suppression of stress analysis models." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387980.
Full textChen, Chun-Chun. "Response to social stress : sensory input, stress response and the neural substrates of reproductive suppression /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textN'Guessan, Prudence. "Décryptage du rôle de TP53INP1 dans la suppression de tumeur." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22070.
Full textOur laboratory has characterized TP53INP1 as a key gene in cell stress response. Target of p53, TP53INP1 is ubiquitously expressed and strongly induced during various stress-inducing treatments in vivo and in vitro. Its ectopic overexpression induces cell cycle arrest and cell death. We have shown that the expression of TP53INP1 is lost in many human cancers and that its re-expression in cancer cells inhibits tumor growth. In addition, TP53INP1-deficient mice are highly susceptible to induced tumors and show a permanent oxidative stress characterized by increased ROS levels. Taken together, these results indicate that TP53INP1 has a tumor suppressor function likely related to its involvement in the regulation of cellular redox status. The purpose of my PhD is to decipher the cellular and molecular function of TP53INP1 by exploiting the model of deficient mice. My work shows that the absence of TP53INP1 affects all biological processes deregulated in tumorigenesis. Indeed, the loss of TP53INP1 is characterized by an increase in cell proliferation, cell migration, angiogenesis and genetic instability. Paradoxically, TP53INP1-deficient cells have increased susceptibility to stress-induced apoptosis, independently or not of p53. This sensitivity is probably based on a strong impairment of autophagy in these cells. We also observed a decrease in the rate of small antioxidant molecules related to constitutive oxidative stress in these mice. The defects observed in the absence of TP53INP1 are corrected by treatment with an antioxidant, N-acetylcysteine, demonstrating the link between the role of TP53INP1 in tumor suppression and its involvement in redox control. This work has led to a better understanding of the antioxidant role of TP53INP1 linked to its function as a tumor suppressor
Blake-Mortimer, Jane. "Lymphocytic 5'-ectonucleotidase : a marker of psychological stress-induced immune suppression /." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phb6364.pdf.
Full textAmstadter, Ananda Beth Laura L. Vernon Laura L. Burkhart Barry R. "Physiological effects of suppression of neutral and traumatic thoughts in posttraumatic stress disorder." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SUMMER/Psychology/Dissertation/AMSTADTER_ANA_20.pdf.
Full textKennedy, Sarah L. "Stress-induced suppression of an antibody response: A role for splenic norepinephrine." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/dissertations/fullcit/3165815.
Full textDrysdale, Shara D. "Posttraumatic stress disorder, thought suppression and the self-regulatory executive function model." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368151.
Full textStoeser, Casey J. "Expressive suppression : relation to post-traumatic stress disorder symptoms and emotional experience /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1456295331&sid=7&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Full textDavies, Mark Ian. "Vulnerability to analogue post-traumatic intrusions and experimental investigations of thought suppression." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308667.
Full textArensdorf, Angela Marie. "The Mechanisms and Consequences of Gene Suppression During the Unfolded Protein Response." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4816.
Full textTeager, Alistair James. "Examining the Effect of Detached Mindfulness, Habituation, and Suppression on Intrusive Thoughts following Exposure to Stress." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525239.
Full textKnauft, Katherine Marie. "Buffering Effects of Grit and Cognitive Reappraisal in the Context of Perceived Stress." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1557500405928633.
Full textCôté, Marilou. "Liens entre le stress conjugal, la suppression émotionnelle et la prise alimentaire au sein de couples hétérosexuels." Doctoral thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27443.
Full textL’étude de l’alimentation induite par le stress et les émotions négatives a été largement menée jusqu’à maintenant en vue d’identifier différentes caractéristiques individuelles pouvant être désignées comme facteur de risque à la suralimentation. À cet effet, le fait de souffrir de surpoids ou d’obésité, de même que la présentation d’un profil alimentaire restrictif ont été identifiés. Bien que certaines études se soient intéressées à la variation des types de stress auxquels sont soumis les individus, aucune n’a élargie sa perspective aux relations de couple. Pourtant, les émotions vécues au sein du couple et la régulation qui en est faite peuvent sans contredit contribuer à l’installation et l’exacerbation de comportements alimentaires problématiques pouvant mener à une prise de poids. En ce sens, à l’aide d’une expérimentation en laboratoire impliquant l’induction d’un stress de nature conjugale, la thèse vise à approfondir les connaissances actuelles quant aux liens qui unissent les émotions vécues dans le contexte d’une discussion conjugale stressante et la prise alimentaire qui s’en suit chez des individus en couple hétérosexuel. Pour ce faire, 80 couples ont été recrutés et ont discuté, en laboratoire, d’aspects qu’ils aimeraient voir changer chez l’autre. La quantité de nourriture consommée suite à la discussion a été mesurée, à leur insu, à l’aide d’un test de goût. Les couples ont été invités à évaluer leur humeur ainsi que la suppression émotionnelle qu’ils ont exercée pendant la discussion, de même qu’à remplir des questionnaires auto-rapportés. L’indice de masse corporelle (IMC) des partenaires a été calculé à partir de mesures objectives. Le premier objectif spécifique de la thèse vise plus particulièrement à étudier l’impact d’un changement d’humeur suite à la discussion conjugale stressante sur la prise alimentaire subséquente des hommes et des femmes, et de tester l’effet modérateur de l’IMC et de la restriction alimentaire sur cette relation. Les résultats indiquent d’abord des associations différentes chez les hommes et les femmes en réponse à la situation expérimentale. Chez les hommes, seules les perceptions d’appétit prédisent la prise alimentaire, tandis que chez les femmes, un patron plus complexe se dessine. Un sous-groupe de femmes à risque de se suralimenter en réponse au stress conjugal est identifié, soit les femmes présentant un IMC élevé et un profil alimentaire restrictif. Ces résultats ajoutent à la littérature actuelle en ce sens où l’impact d’un stresseur de nature conjugale sur la prise alimentaire n’avait jamais été testé auparavant. De plus, ils soulignent l’importance de tenir compte en concomitance de l’IMC et de la restriction dans la compréhension du phénomène de l’alimentation induite par le stress chez les femmes. Le deuxième objectif spécifique de la thèse a pour but d’examiner, à l’aide d’un modèle dyadique, l’effet médiateur de la suppression émotionnelle sur le lien entre le changement d’humeur suite à la discussion conjugale stressante et la prise alimentaire subséquente, en fonction de l’IMC des deux membres du couple. Les résultats de cette étude révèlent que la suppression émotionnelle est un médiateur valide de la relation entre le changement d’humeur et la prise alimentaire, et met également en évidence l’effet modérateur de l’IMC sur cette médiation. Plus particulièrement, la dégradation de l’humeur des individus présentant un IMC élevé est associée à une plus grande prise alimentaire via l’adoption de suppression émotionnelle pendant la discussion avec le partenaire, tandis que chez les individus présentant un IMC faible, la dégradation de l’humeur est plutôt associée à une plus faible prise alimentaire via la suppression. D’un point de vue dyadique, la suppression émotionnelle d’un membre du couple agit comme médiateur de la relation entre le changement émotionnel et la prise alimentaire de son partenaire, sans égard à l’IMC des conjoints. En d’autres mots, la dégradation de l’humeur de l’un mène à une plus grande consommation via la suppression émotionnelle de l’autre. Ces résultats font ressortir le rôle clé de la suppression émotionnelle dans l’alimentation induite par le stress conjugal non seulement au plan individuel, mais également au plan dyadique. Ils soulignent la pertinence de s’intéresser aux interrelations entre les membres d’un couple pour prédire leurs comportements alimentaires. Dans leur ensemble, les travaux de la thèse suggèrent que le couple puisse générer du stress et des affects négatifs qui peuvent mener à la suralimentation. Une attention grandissante devrait être portée à ce type de stresseur dans l’avenir, de même qu’à l’étude de la réponse alimentaire d’un sous-groupe de personnes précis face au stress conjugal, soit les femmes qui présentent des difficultés de régulation du poids et de l’alimentation.
Stress-induced eating has been widely studied up until now in order to identify individual characteristics which may be designated as risk factors to overeating. Being overweight or obese, as well as being a restrained eater, have been identified. Although some studies have investigated the impact of different types of stressors on eating, none has broadened its investigation on romantic relationships. However, emotions experienced through couple interactions as well as the way partners deal with (or regulate) those emotions may certainly contribute to the development and exacerbation of problematic eating behaviors that can lead to weight gain. Thus, using a laboratory experiment involving a dyadic stress, the present thesis aims to deepen the current understanding of the relationship between emotions following a stressful couple discussion and food intake among heterosexual couples. Eighty couples were recruited and discussed an aspect that they wanted their partner to change. Food intake was measured following the discussion with a bogus taste test. Both partners assessed their mood state, as well as emotion suppression, and completed self-reported questionnaires. Body mass index (BMI) was calculated with objective measures. The first specific objective of the thesis was to examine the impact of mood change induced by a stressful couple discussion on food intake in both spouses, while simultaneously taking into account the moderating effect of BMI and restraint on this association. First, results showed different responses in men and women following the discussion. Among men, only appetite perceptions significantly predicted food intake, while a more complex pattern emerged among women. A subgroup of women at risk to overeat in response to dyadic stress was identified, those with a high BMI and a restrictive eating profile. These results add to the current literature since the impact of a dyadic stressor on food intake had never been tested before. Moreover, these results highlight the importance of considering the concomitant effect of BMI and restraint in the understanding of stress-induced eating among women. The second specific objective of the thesis was to examine, using dyadic analysis, whether emotion suppression was a valid mediator in the relationship between mood change following a stressful couple discussion and subsequent food intake among couples, while taking into account spouses’ BMI. Results showed that emotion suppression was a valid mediator in the relationship between mood change and food intake, and that BMI significantly moderated this mediation. That is, mood worsening was related to high food intake through emotion suppression among high BMI spouses, while for low BMI spouses, mood worsening rather predicted low food intake through emotion suppression. Dyadic analysis revealed that emotion suppression in one partner acted as a mediator in the association between mood change and food intake in the other partner, regardless of BMI. In other words, mood worsening of one partner led to a greater consumption of food via emotion suppression in the other partner. These results emphasise the key role of emotion suppression in the relationship between mood change and food intake in the context of a stressful couple discussion. They also underscore the relevance to focus on the interrelationships between spouses to predict their eating behaviors. Taken together, the thesis results suggest that romantic relationships can generate stress and negative emotions that can lead to overeating. More attention should be paid to this type of stressor in the future, as well as to the study of the eating response to dyadic stress of a specific subgroup of people, i.e. women presenting eating and weight regulation issues.
Millet, Yves. "Suppression of Arabidopsis thaliana root innate immunity by Pseudomonas syringae phytotoxin coronatine and functional studies of the cytochrome P450 CYP76C2." Strasbourg, 2009. https://publication-theses.unistra.fr/public/theses_doctorat/2009/MILLET_Yves_2009.pdf.
Full textOver the course of evolution, plants developed sophisticated defense mechanisms against bacterial and fungal pathogens. One of the first layers of plant defense is called PAMP triggered immunity (PTI) and is based on the recognition of conserved epitopes of pathogen-derived molecules called PAMPs/MAMPs (Pathogen/Microbe Associated Molecular Patterns). This recognition activates defense responses including the deposition of callose at the site of pathogen attack. Despite the fact that roots are the organs most subject to microbial interactions, MAMP signaling in roots remains largely unexplored. I developed an Arabidopsis thaliana seedling assay to study PTI in roots based on the detection of callose and the activation of promoter:GUS reporters of MAMP-responsive genes. I found that MAMPs trigger a strong response in roots dependent on ethylene signaling, the MYB51 transcription factor, the cytochrome P450 CYP81F2, and the PEN2 myrosinase, but independent of salicylic acid signaling. In addition, I show that the bacteria Pseudomonas syringae and Pseudomonas fluorescens suppress this response and that P. Syringae is doing so by producing the phytotoxi coronatine. I found that coronatine acts via the E3 ligase COI1 and the transcription factor JIN1/MYC2. I performed a forward genetic screen to isolate mutants impaired in COR-mediated suppression in an attempt to identify new players involved in COR signaling. In this thesis, I also present data concerning CYP76C2, a gene encoding a cytochrome P450 that is highly induced by MAMPs and pathogens in Arabidopsis leaves. I confirmed that CYP76C2 is activated during pathogen infection and various cell death elicited scenarios. Furthermore, I demonstrate that CYP76C2 is partially dependent on SA signaling and may be involved in controlling oxidative damage during infection
Tseng, Raymond J. "Stress-induced suppression of natural killer cell activity during influenza viral infection the role of glucocorticoids and opioids /." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1148586277.
Full textGupta, Prachi. "SYNTHESIS AND CHARACTERIZATION OF ANTIOXIDANT CONJUGATED POLY(ΒETA-AMINO ESTER) MICRO/NANOGELS FOR THE SUPPRESSION OF OXIDATIVE STRESS." UKnowledge, 2016. http://uknowledge.uky.edu/cme_etds/58.
Full textVincent, Annabelle Carole. "Effets de la suppression du stress de la naissance et de l'adoption sur le développement et le comportement de jeunes rats." Rouen, 2003. http://www.theses.fr/2003ROUEL458.
Full textAt least in mammals, birth represents an important physical stress for the newborn. The present study was aimed to dtermine the effects of elimination of this "birth stress" on development and behavior of young term rats, observed until the adult stage. The second aim of this study was to determine the short-and-long-term consequences of fostering at birth. Several experiments were organized to test the influence of the mode of delivery (cesarean section or spontaneous vaginal delivery), the cesarean delivery allowing the avoidance by fetuses of suffering stress due to their compression of the genital tract during strong uterine contractions and acute birth hypoxia, and the postnatal development environment (fostering or rearing by the natural mother). The foster dams were spontaneously dillivered two days peviously or at the same time than other biological dams, and their behavior was also studied. The results show that : - corticoid secretion, at birth, was lower in rat pups delivered by cesarean section than in those naturally born, indicating that natural birth is indeed a stressful event. - in-fostering modified dam's activities directly towards the pups, but the mode of pups'birth seemed to have no major effect on maternal behavior - in-fostering per se resulted in mortality of neonates soon following adoption but; which continued at least throughout the first month of life, with a neonatal growth retardation of surviving pups fostered by dams which were delivered two days previously, an enhanced trait anxiety, modifications of social behavior, and impairments of working memory. - cesarean section birth had catastrophic effects on death and weight gain of survivors at least throughout the neonatalperiod, and elicited a long-lasting hyperactivity only in rats fostered by dams which delivered two days previously, disturbances of emotional behavior, behavioral modifications during social interactions and dysfunction in short-or long-term memory. Thus, mild modification of birth conditions or early change of maternal environment is sufficient to influence the development of young and the emotional and cognitive functions of adult
Malueg, Amanda Leah. "Stress in the Red-cockaded Woodpecker: Hormonal Mechanisms of Reproductive Suppression in Helper Males and Impacts of Military Training Activities." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/35091.
Full textMaster of Science
Taniguchi, Masayuki. "Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice." Kyoto University, 2018. http://hdl.handle.net/2433/232116.
Full textCates, Philippa Susan. "Elucidating the neural mechanisms underlying stress-induced suppression of the gonadotrophin releasing hormone pulse generator in the female rat." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392328.
Full textYoshizumi, Takahiro, and Satomi Murase. "The effect of avoidant tendencies on the intensity of intrusive memories in a community sample of college students." Elsevier, 2007. http://hdl.handle.net/2237/9098.
Full textMizon, Guy Andrew. "Is expressive flexibility related to recovery from a stressful task?" Thesis, University of Exeter, 2012. http://hdl.handle.net/10036/3874.
Full textYarar, Orhan Ferhat. "Effects Of Inhibitory Mechanisms And Thought Suppression Tendency On The Frequency And Intensity Of Traumatic Intrusions." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612926/index.pdf.
Full textresponse inhibition and proactive inhibition levels and tendency to suppress thoughts were measured prior to exposure to a trauma film. One week after seeing the trauma film, participants reported the frequency and intensity of trauma film related intrusions with an intrusion diary and Impact of Events Scale. No significant effect of response inhibition, proactive inhibition and thought suppression tendency was found on the frequency and intensity of trauma film related intrusions. Findings of the study are discussed.
Finzel, Pérez Ana [Verfasser]. "Upstream control and downstream responses of p53 are involved in its tumor suppression functions upon genotoxic stress / Ana Finzel Pérez." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1122111193/34.
Full textBenayoun, Bérénice. "Foxl2 : un facteur de transcription essentiel de l'ovaire, à l'interface entre la réponse au stress cellulaire et la suppression tumorale." Paris 7, 2011. http://www.theses.fr/2011PA077006.
Full textFOXL2 is a transcription factor, mutated in the Blepharophimosis Syndrome (BPES), characterized by craniofacial defects, either isolated (type II) or associated with ovarian dysfunction (type I). We found that FOXL2 is a highly post-translationally modified protein, and uncovered a novel mechanism of maturation. We also identified a high-affinity FoxL2 Response Element, which was instrumental to set up a diagnostic tool predicting the occurrence of ovarian dysfunction in BPES patients. We also showed that FOXL2 was involved in the cell stress response. Indeed, we found that oxidative stress up-regulated FOXL2 in granulosa cells, increased its acetylation and its transactivation. Consistently, FOXL2 upregulation protects cells against oxidative stress. We identifiée SIRT1 as a FOXL2 negative regulator and a direct target gene, proving the existence of a negative-feedback loop. Clinical studies found that FOXL2 misregulation may drive malignant transformation of granulosa cells, pointing to a tumor suppressor role. Study of FOXL2 target genes revealed cell-cycle progression as a significant FOXL2-regulated pathway. Indeed, FOXL2 over-expression led to accumulation of cells in the Gl-phase and increased repair of DNA oxidation damage. We tested the effect of SIRT1 inhibition with nicotinamide, which increases FOXL2 levels, on granulosa tumor cells. Indeed, this treatment interfered with cell cycle progression. In short, this PhD work implicates FOXL2 as a novel regulator of stress response and proliferation in granulosa cells, which gives new insights into the pathogenic consequences of its deregulation
Bowe, James Edward. "The role of CGRP in stress-induced suppression of the GnRH pulse generator and thermo regulatory responses in the female rat." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429402.
Full textCooper, Richard James. "Effects of chemical seedhead suppression on the carbohydrate status, quality, rooting, and heat stress tolerance of annual bluegrass (Poa annua L.) /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487260135357518.
Full textFriedrich, Anja [Verfasser], Sophia [Akademischer Betreuer] Sonnewald, and Sophia [Gutachter] Sonnewald. "Role of the Coxiella burnetii type IV effector protein CaeB in cell death suppression and ER stress signaling / Anja Friedrich ; Gutachter: Sophia Sonnewald ; Betreuer: Sophia Sonnewald." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/1235757722/34.
Full textLabbé, Adam. "Profil d'expression des fibroblastes de souris embryonnaires avec une suppression dans le domaine hélicase de l'homologue du gène Werner traité avec du peroxyde d'hydrogène." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/28800/28800.pdf.
Full textSchäfer, Claudia [Verfasser], Krämer Oliver Akademischer Betreuer] H, Frank [Akademischer Betreuer] [Große, and Martin [Akademischer Betreuer] Göttlicher. "Modulation of the replication stress response by histone deacetylases is connected to suppression of the PP2A regulatory subunit PR130 / Claudia Schäfer. Gutachter: Krämer Oliver H. ; Frank Große ; Martin Göttlicher." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2015. http://d-nb.info/1066238278/34.
Full textCunniffe, Brian. "Effect of acute and chronic exercise on immunoendocrine responses in professional rugby union." Thesis, University of South Wales, 2009. https://pure.southwales.ac.uk/en/studentthesis/effect-of-acute-and-chronic-exercise-on-immunoendocrine-responses-in-professional-rugby-union(bc7a6dfd-67e1-4e63-965e-a61333245818).html.
Full textMatos, Rodrigues Gabriel Eduardo de. "Suppression of Homologous Recombination by RAD51 Functional Inactivation In Vivo in Mice Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response In Vivo Suppression of Homologous Recombination Leads to a Systemic Inflammation That Exacerbates Mouse Death Functional Inactivation of RAD51 in Adult Mice Leads to Premature Aging Without Tumor Development Inactivation of Trp53 Accelerates Mouse Death After RAD51 Functional Inactivation in Adult Mice Without Increasing Tumor Formation RAD51 Functional Inactivation Inhibits Mammary Tumor Initiation and Progression in Mice." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL073.
Full textHomologous recombination (HR) is an evolutionary conserved process that plays a prominent role in genome plasticity, controlling the balance of genetic stability/diversity. The pivotal step of HR,i.e. DNA homology search and strand exchange, is governed by the RAD51-ssDNA (single-stranded DNA) filament that must be well ordered, thus representing the actual active species of HR. HR impairment is linked to human developmental syndromes and cancer. However, since RAD51 is an essential gene in mice, the consequences of functional disruption of RAD51 remain to be studied in vivo. Here we developed an inducible dominant negative form of RAD51 (SMRAD51) to poison HR in vivo. Using biochemical approaches, we demonstrate that SMRAD51 disrupts RAD51-dependent strand-exchange and RAD51-ssDNA filament formation. SMRAD51 expression leads to replicative stress in vitro and in vivo, triggering progenitor exhaustion. We show that functional inactivation of RAD51 in growing mice (starting from 12 to 14 days after birth) triggers a systemic inflammatory response causing mouse death within a few days. Meanwhile, RAD51 functional disruption in adult mice induces premature aging phenotypes and reduced lifespan prior to putative tumorigenesis. In addition, we show that RAD51 functional inactivation inhibits tumor initiation and progression in a mouse model of breast cancer. Overall, here I uncover new pro-aging and anti-tumor mechanisms generated by the functional inactivation of RAD51
Huang, Shirley Chien-Chieh 1978. "Control of tumor suppressor p53 by protein phosphorylation and ER stress." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78384.
Full textCurato, John. "Inheritance of resistance to wheat streak mosaic virus in wheat line KS06HW79." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/32918.
Full textDepartment of Agronomy
Guorong Zhang
Guihua Bai
Wheat streak mosaic virus (WSMV) is a disease that causes significant yield losses in wheat (Triticum aestivum L.). Host resistance is the primary approach for control. KS06HW79 is a wheat line with WSMV resistance up to 21°C. To study the inheritance of resistance in KS06HW79, it was crossed with two WSMV-susceptible wheat genotypes, KS020638-M-5 and Brawl CL Plus. Parental lines, F₁, F₂, and check varieties were mechanically inoculated and evaluated for WSMV resistance at 21°C in growth chambers. The segregation pattern in two F₂ populations fit a one-recessive-gene model (1 resistant : 3 susceptible) and a dominant-suppression-epistasis model (3 resistant : 13 susceptible). To determine which model was a better fit, WSMV resistance was evaluated for F₂:₃ families generated from resistant F₂ plants in both crosses. Approximately two thirds of the F₂:₃ families in each cross showed segregation for WSMV resistance, suggesting that the dominant-suppression epistasis model better explained the WSMV resistance in KS06HW79. This model was also supported by two KS06HW79-derived doubled haploid populations, which had a segregation ratio of 1 resistant : 3 susceptible. Therefore, the WSMV resistance in KS06HW79 is likely controlled by two dominant genes, one of which is a suppressor.
Latonen, Leena. "Tumor suppressor p53 and transcriptional changes in cellular stress responses to UV radiation." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/latonen/.
Full textHata, Masayuki. "KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress." Kyoto University, 2018. http://hdl.handle.net/2433/232075.
Full textTang, Kei-shuen, and 鄧紀旋. "Role of BRCA1 in stress-induced autophagy in breast and ovarian cancercells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45847204.
Full textAflalo, Bernardo Santos. "CFD and CAA analysis of single stream isothermal jets with noise suppression devices." Instituto Tecnológico de Aeronáutica, 2009. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=1210.
Full textHusaini, Roslina. "Towards the Investigation of the Effects of Nitration on the Activity of the Human p53 Tumour Suppressor Protein. Nitration of the p53 Tumour Suppressor Protein." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/14788.
Full textMinistry of Science, Technology and Innovation (MOSTI) of Malaysia
Kwan, Wai-yin. "Glucose-regulated protein 78 as a novel target of BRCA1 for inhibiting stress-induced apoptosis." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B4163391X.
Full textPluquet, Olivier. "Activation de la protéine onco-suppressive P53 par le cytoprotecteur amifostine : définition d'une voie signalétique d'activation indépendante du stress-génotoxique." Paris 5, 2002. http://www.theses.fr/2002PA05P616.
Full textThe p53 protein is a trancription factor activated in response to genotoxic stresses (radiation, chemotherapeutic drugs) and non-genotoxic stresses. WR1065 is an aminothiol used in therapy to protect healthy cells from the side effects of anti-cancer therapies. Its protective effects are thought to be mediated by its ability to scavenge reactive oxygen species, however, the molecular basis of its specificity for normal tissues is unknown. The p53 protein, which is sensitive to redox conditions, is often inactivated in cancers. P53 could be an important target of WR1065. Our results show that in our cellular model, WR1065 activates p53, which transactivates its target genes and induces a p53-dependent G1 arrest. Moreover, WR1065 induces at least in part, a p53-dependent cytoprotection. Induction of p53 is characterized by a signaling pathway which differs from the one used by DNA damaging agents. .
Chaudhuri, Leena. "Manganese superoxide dismutase (MnSOD) 3'-untranslated region: a novel molecular sensor for environmental stress." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/2682.
Full textSchmerr, Martin J. "THE FUNCTIONAL SIGNIFICANCE OF AN ALTERNATELY SPLICED PRODUCT OF THE HDM2GENE." Ohio : Ohio University, 2007. http://www.ohiolink.edu/etd/view.cgi?ohiou1173370332.
Full textWang, Di. "Extending Complex Event Processing for Advanced Applications." Digital WPI, 2013. https://digitalcommons.wpi.edu/etd-dissertations/235.
Full textChristian, Kyle. "The role of hnRNP A1 and hnRNP C1/C2 in the regulation of the stress responsive genes Cyp2a5/2A6 and p53." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8722.
Full textThe family of proteins known as heterogeneous nuclear ribonucleoproteins (hnRNPs) is large and diverse. Often, one and the same hnRNP will perform multiple cellular functions, leading to their description as “multifunctional proteins”. The two hnRNPs known as hnRNP A1 and hnRNP C1/C2 are multifunctional proteins found to affect the transcription, splicing, stability, and translation of specific genes’ mRNA. They are implicated in carcinogenesis, apoptosis, and DNA damage response mechanisms.
The aims of this thesis were to study the hnRNP A1 and hnRNP C1/C2 dependent regulation of two highly stress responsive genes, the tumor suppressor p53 and the cytochrome P450 enzyme Cyp2a5/CYP2A6. We identified hnRNP C1/C2 as a DNA damage induced binding protein towards the coding region of p53 mRNA, and found that while a specific cis binding site appears to have a positive function in p53 expression, interaction of hnRNP C1/C2 with this site represses the expression. The data suggest that two distinct molecular mechanisms exist for the down-regulation of p53 by hnRNP C1/C2. One mechanism, active during transcriptional stress, is dependent upon the aforementioned site, and the other, independent. We discuss how hnRNP C1/C2 dependent repression of p53 may play a role in apoptosis.
The data presented here further suggest that the transcriptional and post-transcriptional processes controlling the expression of the murine Cyp2a5 gene are linked via hnRNP A1, by performing functions in the nucleus as a transcription factor, or in the cytoplasmic compartment as a trans factor bound to the 3’UTR of the mRNA as needed. Our studies of the human ortholog of this gene, CYP2A6, suggest that this gene is regulated post-transcriptionally in a manner similar to that of its murine counterpart, via changes in mRNA stability and interaction of hnRNP A1 with its 3’ UTR.
Recchia, Gustavo Henrique. "Identificação de genes diferencialmente expressos em feijoeiro envolvidos na resistência ao estresse hídrico." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/64/64133/tde-11102011-085802/.
Full textDrechsler, Frank Verfasser], Jan [Akademischer Betreuer] Schirawski, and Joost T. van [Akademischer Betreuer] [Dongen. "Suppressor of apical dominance1 of the maize pathogen Sporisorium reilianum induces outgrowth of subapical ears by induction of abiotic stress response / Frank Drechsler ; Jan Schirawski, Joost Thomas van Dongen." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1162499222/34.
Full textDrechsler, Frank [Verfasser], Jan Akademischer Betreuer] Schirawski, and Joost T. van [Akademischer Betreuer] [Dongen. "Suppressor of apical dominance1 of the maize pathogen Sporisorium reilianum induces outgrowth of subapical ears by induction of abiotic stress response / Frank Drechsler ; Jan Schirawski, Joost Thomas van Dongen." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1162499222/34.
Full textNovas, Anabela M. P. C. "Tennis training, upper respiratory tract infections and salivary immunoglobulin A." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/36789/1/36789_Digitised%20Thesis.pdf.
Full textGilkes, Daniele M. "Multiple modes of MDMX regulation affect p53 activation." [Tampa, Fla.] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002312.
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