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Relevant bibliographies by topics / Stress signalling pathway

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Academic literature on the topic 'Stress signalling pathway'

Author: Grafiati

Published: 8 March 2025

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Journal articles on the topic "Stress signalling pathway"

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MATHIAS, Shalini, Louis A. PEÑA, and Richard N. KOLESNICK. "Signal transduction of stress via ceramide." Biochemical Journal 335, no. 3 (1998): 465–80. http://dx.doi.org/10.1042/bj3350465.

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The sphingomyelin (SM) pathway is a ubiquitous, evolutionarily conserved signalling system analogous to conventional systems such as the cAMP and phosphoinositide pathways. Ceramide, which serves as second messenger in this pathway, is generated from SM by the action of a neutral or acidic SMase, or by de novosynthesis co-ordinated through the enzyme ceramide synthase. A number of direct targets for ceramide action have now been identified, including ceramide-activated protein kinase, ceramide-activated protein phosphatase and protein kinase Cζ, which couple the SM pathway to well defined intr

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Šrámek, Jan, Vlasta Němcová-Fürstová та Jan Kovář. "Molecular Mechanisms of Apoptosis Induction and Its Regulation by Fatty Acids in Pancreatic β-Cells". International Journal of Molecular Sciences 22, № 8 (2021): 4285. http://dx.doi.org/10.3390/ijms22084285.

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Pancreatic β-cell failure and death contribute significantly to the pathogenesis of type 2 diabetes. One of the main factors responsible for β-cell dysfunction and subsequent cell death is chronic exposure to increased concentrations of FAs (fatty acids). The effect of FAs seems to depend particularly on the degree of their saturation. Saturated FAs induce apoptosis in pancreatic β-cells, whereas unsaturated FAs are well tolerated and are even capable of inhibiting the pro-apoptotic effect of saturated FAs. Molecular mechanisms of apoptosis induction by saturated FAs in β-cells are not complet

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Zhang, Shengrui, Klaus Apel, and Chanhong Kim. "Singlet oxygen-mediated and EXECUTER-dependent signalling and acclimation of Arabidopsis thaliana exposed to light stress." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1640 (2014): 20130227. http://dx.doi.org/10.1098/rstb.2013.0227.

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Plants respond to environmental changes by acclimation that activates defence mechanisms and enhances the plant's resistance against a subsequent more severe stress. Chloroplasts play an important role as a sensor of environmental stress factors that interfere with the photosynthetic electron transport and enhance the production of reactive oxygen species (ROS). One of these ROS, singlet oxygen ( 1 O 2 ), activates a signalling pathway within chloroplasts that depends on the two plastid-localized proteins EXECUTER 1 and 2. Moderate light stress induces acclimation protecting photosynthetic mem

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Desideri, Enrico, and L. Miguel Martins. "Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease." International Journal of Cell Biology 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/607929.

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Mitochondria are cellular energy generators whose activity requires a continuous supply of oxygen. Recent genetic analysis has suggested that defects in mitochondrial quality control may be key factors in the development of Parkinson’s disease (PD). Mitochondria have a crucial role in supplying energy to the brain, and their deterioration can affect the function and viability of neurons, contributing to neurodegeneration. These organelles can sow the seeds of their own demise because they generate damaging oxygen-free radicals as a byproduct of their intrinsic physiological functions. Mitochon

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Ma, Chen-Yu, Yu-Qian Ma, and Min Deng. "Mechanism of Zhen Wu Decoction in the Treatment of Heart Failure Based on Network Pharmacology and Molecular Docking." Evidence-Based Complementary and Alternative Medicine 2022 (March 15, 2022): 1–10. http://dx.doi.org/10.1155/2022/4877920.

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Heart failure (HF) is a serious manifestation or advanced stage of various cardiovascular diseases, and its mortality and rehospitalization rate are still on the rise in China. Based on the network pharmacology method, 59 components of Zhen Wu decoction (ZWD) and 83 target genes related to HF were obtained. Through the PPI network, four potential therapeutic targets were identified: AKT1, IL6, JUN, and MAPK8. The beneficial components of ZWD might intervene HF through the AGE-RAGE signalling pathway in the diabetes component, fluid shear stress and atherosclerosis, the TNF signalling pathway,

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Whitmarsh, A. J. "The JIP family of MAPK scaffold proteins." Biochemical Society Transactions 34, no. 5 (2006): 828–32. http://dx.doi.org/10.1042/bst0340828.

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The components of MAPK (mitogen-activated protein kinase) signalling pathways can assemble into complexes that are co-ordinated by regulatory proteins including scaffold proteins. There is increasing evidence that scaffold proteins (i) maintain signalling specificity and facilitate the activation of pathway components, (ii) localize pathway components to particular subcellular sites or to specific targets, and (iii) serve as a point of signal integration to allow regulation of MAPK pathways by other signalling events in the cell. One family of scaffold proteins that regulate signalling by stre

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Verma, Poonam, Amit Ghosh, Manisha Ray, and Saurav Sarkar. "Lauric Acid Modulates Cancer-Associated microRNA Expression and Inhibits the Growth of the Cancer Cell." Anti-Cancer Agents in Medicinal Chemistry 20, no. 7 (2020): 834–44. http://dx.doi.org/10.2174/1871520620666200310091719.

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Background: microRNAs are known to regulate various protein-coding gene expression posttranscriptionally. Fatty acids are cell membrane constituents and are also known to influence the biological activities of the cells like signal transduction, growth and differentiation of the cells, apoptosis induction, and other physiological functions. In our experiments, we used lauric acid to analyse its effects on human cancerous cell lines. Objective: Our objective was to speculate the miRNA expression profile in lauric acid treated and untreated cancerous cell lines and further study the metabolic pa

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Tiong, Yee Lian, Khuen Yen Ng, Rhun Yian Koh, Gnanajothy Ponnudurai та Soi Moi Chye. "Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways". Antioxidants 8, № 7 (2019): 198. http://dx.doi.org/10.3390/antiox8070198.

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Neuropathy is a complication that affects more than 50% of long-standing diabetic patients. One of the causes of diabetes neuropathy (DN) is the apoptosis of Schwann cells due to prolonged exposure to high glucose and build-up of oxidative stress. Melatonin is a hormone that has a known antioxidant property. In this study, we investigated the protective effect of melatonin on high glucose-induced Schwann cells’ apoptosis. Our results revealed that high glucose promoted apoptosis via mitochondrial-related oxidative stress and downregulated Bcl-2 family proteins in Schwann cells. In this signall

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Zhou, Xiang, Guoyin An, and Xiang Lu. "Hydrogen sulfide attenuates the development of diabetic cardiomyopathy." Clinical Science 128, no. 5 (2014): 325–35. http://dx.doi.org/10.1042/cs20140460.

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H2S alleviates diabetic cardiomyopathy via attenuation of inflammation, oxidative stress and apoptosis. H2S may reduce high glucose-induced oxidative stress by activating the Nrf2/ARE pathway and exert anti-apoptotic effects by inhibiting JNK and p38 MAPK pathways and activating PI3K/Akt signalling.

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Thoms, Hazel C., та Lesley A. Stark. "The NF-κB Nucleolar Stress Response Pathway". Biomedicines 9, № 9 (2021): 1082. http://dx.doi.org/10.3390/biomedicines9091082.

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The nuclear organelle, the nucleolus, plays a critical role in stress response and the regulation of cellular homeostasis. P53 as a downstream effector of nucleolar stress is well defined. However, new data suggests that NF-κB also acts downstream of nucleolar stress to regulate cell growth and death. In this review, we will provide insight into the NF-κB nucleolar stress response pathway. We will discuss apoptosis mediated by nucleolar sequestration of RelA and new data demonstrating a role for p62 (sequestosome (SQSTM1)) in this process. We will also discuss activation of NF-κB signalling by

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Dissertations / Theses on the topic "Stress signalling pathway"

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Darling, Nicola Jane. "Regulation of ER stress-induced cell death by the ERK1/2 signalling pathway." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708709.

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Brown, Christopher Martin. "Intracellular mechanisms of stress-induced LTP impairment : a signalling pathway triggered by corticosterone in the rat hippocampus." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715798.

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Hendricks, Kaylin. "Signalling molecule “calcium” improves germination and growth of Sorghum bicolor seedlings under salt stress." University of the Western Cape, 2021. http://hdl.handle.net/11394/8254.

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>Magister Scientiae - MSc<br>Abiotic stress, mainly in the form of extreme temperatures, drought and salinity has caused major crop losses worldwide, putting a severe strain on agriculture. Salinity severely limits plant growth and productivity and affects all aspects of the plant’s development including the most crucial stage; germination. This study investigated the effect of salt (NaCl) stress on Sorghum bicolor seedlings and the role of exogenously applied calcium (Ca2+) to ameliorate the effects of salt stress during germination. Sorghum seeds were germinated in the presence and absence o

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Abrahams, Amaal. "Regulation of the anti-senescence factor, TBX2, by the UV stress signalling pathway and the mitotic cyclin dependent kinases." Doctoral thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/24805.

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The T-box gene family has achieved great prominence in the field of developmental biology because its members have been demonstrated to play important roles in embryonic development and mutations within several T-box genes are associated with a number of human congenital diseases. Several lines of evidence have also implicated members of the T-box gene family in cell cycle regulation and in cancer. Importantly, the highly related T-box factors, Tbx2 and Tbx3, can suppress senescence through repressing the cyclin dependent kinase inhibitors, p21wAF11 c1P118011 and p19ARF. Both Tbx2 and Tbx3 hav

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Pacini, Laura. "Deregulation of TLR9 signalling pathway in human keratinocytes by E6 and E7 oncoproteins from beta human papillomavirus type 38." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1321/document.

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Les virus du papillome humain (HPV) sont des virus à ADN double-brin encapsidés appartenant à la famille des Papillomaviridae ayant un tropisme distinct pour les épithéliums squameux de type muqueux ou cutanés. Jusqu'à présent, plus de 200 types de HPV ont été isolés et regroupés dans un arbre phylogénétique composé de 5 genres nommés alpha, beta, gamma, mu et nu. Parmi eux, les types HPV muqueux à haut risque appartenant au genre alpha ont été associés au cancer du col de l'utérus ainsi qu'à des sous-groupes de carcinomes ano-génitaux et de la tête et du cou. Ces virus sont responsables d'env

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Minnaar, Estella Lily. "Regional neurochemical characterization of the flinders sensitive line rat with regard to glutamate-nitric oxide and cGMP signalling pathways / Estella Lily Minnaar." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4214.

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The serious nature of MDD has intensified the need to identify and elucidate new neurobiological targets for antidepressant drug action. Depression presents with evidence for degenerative pathology that relates to disturbances in excitatory glutamatergic pathways, particularly the N-methyl-D-aspartate (NMDA) receptormediated release of the pleiotropic molecule, nitric oxide (NO), and cyclic guanosine monophosphate (cGMP). The contribution of the glutamate-NO/cGMP pathway may realize great importance as a fundamental substrate underlying the pathophysiology of major depression. In the next gene

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Pai, Mangalore Govind [Verfasser], Ignacio [Gutachter] Rubio, Regine [Gutachter] Heller, and Fried JT [Gutachter] Zwartkruis. "The role of mTOR signalling pathway as a susceptibility factor in genotoxic stress-induced cell death / Mangalore Govind Pai ; Gutachter: Ignacio Rubio, Regine Heller, Fried J. T. Zwartkruis." Jena : Friedrich-Schiller-Universität Jena, 2016. http://d-nb.info/1177613492/34.

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Chaput, Carole. "Therapeutic functionalization of a rare neurodevelopmental and monogenic disease model based on the contribution of the HSF2 stress pathway." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5190.

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Les troubles neurodéveloppementaux (TND) touchent environ 10 % des enfants et constituent une source majeure d'invalidité tout au long de la vie. Caractérisés par un développement défectueux du cerveau et une grande variabilité du tableau clinique des patients, qui compromet le diagnostic et l'émergence de solutions thérapeutiques, ils représentent un coût humain, sociétal et économique important. L'objectif de ce projet est de mieux comprendre une caractéristique commune des TND - la dérégulation des voies de réponse au stress - qui constituerait une clef de lecture pour comprendre ces pathol

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Samuels, Michael L. "Yeast stress signalling." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368116.

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Kritsiligkou, Paraskevi. "Peroxiredoxins : yeast redox switches that regulate multiple cellular pathways." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/peroxiredoxins-yeast-redox-switches-that-regulate-multiple-cellular-pathways(fbb44664-5021-4dbc-88c7-64aef8a6c045).html.

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Peroxiredoxins are small ubiquitous cysteine-containing proteins that exhibit high reactivity to hydrogen peroxide. Apart from their role as antioxidants, detoxifying hydrogen peroxide to water, peroxiredoxins have been implicated in other cellular processes, such as protein folding and signalling. Using S. cerevisiae as a model organism, we utilised a variety of techniques to examine previously unexplored links between peroxiredoxins and mitochondrial function. Firstly, we characterised the role of Gpx3 in yeast mitochondria. Proteomic work revealed the presence of Gpx3 in the mitochondrial i

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Books on the topic "Stress signalling pathway"

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Lacal, Carlos. Signalling Pathways in Abiotic Stress. Arcler Education Inc, 2017.

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Wentzel, Jolanda J., Ethan M. Rowland, Peter D. Weinberg, and Robert Krams. Biomechanical theories of atherosclerosis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0012.

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Atherosclerosis, the disease underlying most heart attacks and strokes, occurs predominantly at certain well-defined sites within the arterial system. Its development may therefore depend not only on systemic risk factors but also on locally varying biomechanical forces. There are three inter-related theories explaining the effect of biomechanics on atherosclerosis. In the first theory, a central role is played by lipid transport into the vessel wall, which varies as a result of mechanical forces. In the second theory, haemodynamic wall shear stress-the frictional force per unit area of endoth

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Book chapters on the topic "Stress signalling pathway"

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Ferrando, Alejandro, Pedro Carrasco, Juan Cruz Cuevas, Teresa Altabella, and Antonio F. Tiburcio. "Integrated Molecular Analysis of the Polyamine Metabolic Pathway in Abiotic Stress Signalling." In Plant Ecophysiology. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-1-4020-2728-4_8.

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Feng, Jia-fu. "Biomarkers of Oxidative Stress." In Targeting Cellular Signalling Pathways in Lung Diseases. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-6827-9_32.

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Singh, Shilpy, Ruth Assumi, and Pooja Bhadrecha. "Crosstalk of MicroRNAs with Phytohormone Signalling Pathways." In Plant MicroRNAs and Stress Response. CRC Press, 2023. http://dx.doi.org/10.1201/9781003322214-15.

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Asif, Iqbal, Iqbal Mazhar, Alamzeb Madeeha, et al. "Cross-Talk between Phytohormone-Signalling Pathways under Abiotic Stress Conditions." In Plant Growth Regulators for Climate-Smart Agriculture. CRC Press, 2021. http://dx.doi.org/10.1201/9781003109013-7.

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Sehrawat, Ankita, and Renu Deswal. "Proteomics Approach to Uncover Key Signalling Pathways in Brassica juncea in Abiotic and Biotic Stress." In The Brassica juncea Genome. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-91507-0_19.

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Achhelal Yadav, Ms Bijal, Mr Akshat Sunil Jain, Mr Abhiram Rajesh Patil, and Ms Somya Rajesh Singh. "VERICIGUAT: A MIRACULOUS THERAPEUTIC AGENT FOR HEART FAILURE." In Futuristic Trends in Medical Sciences Volume 3 Book 13. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bdms13p2ch7.

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The NO-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway regulates cardiovascular function and is disturbed in heart failure (HF), resulting in diminished protection against myocardial damage. In HF, impaired NO-sGC-cGMP signalling is caused by decreased NO bioavailability and an altered redox state of sGC, which makes it less sensitive to NO. Cinaciguat, a sGC activator, raises cGMP levels by direct NO-independent sGC activation and may be especially beneficial under settings of increased oxidative stress and endothelial dysfunction, and therefore lower NO levels, at the price of an increased risk of hypotension. sGC stimulators, on the other hand (riociguat and vericiguat), increase sGC sensitivity to endogenous NO, resulting in a more physiological effect. The review focuses on the complete drug profile of Vericiguat.

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S, Deepa, Kalaivani S, Sathesh Kumar K, Mohammed Wasim Khan N, Anusha T, and Neeraja S. "HEAT SHOCK PROTEINS: THE CELLULAR SUPERHEROES UNVEILED!" In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 6. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn6p1ch9.

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A family of molecular chaperones known as heat shock proteins (HSPs) is highly conserved and essential for cellular homeostasis and stress response control. HSPs were first recognised as stress-induced proteins, but they have now expanded beyond their typical functions in protein folding and unfolding to become key actors in a number of cellular processes. The goal of this review is to give a thorough summary of what is currently known about heat shock proteins, their various roles, and how they affect cellular physiology. Beginning with the taxonomy and structural organisation of HSPs, the review will go into detail about large families like Hsp70, Hsp90, Hsp60, and tiny HSPs. Emphasising the crucial role, they play in preserving proteostasis under physiological and stressful settings, their chaperoning actions in protein folding and refolding will be clarified. They will also be emphasised for their role in cellular trafficking and transport activities. The review will also cover how HSP expression is dynamically regulated in response to stressors such heat, oxidative stress, heavy metals, and infections. The discussion about complex mechanisms underlying HSP gene expression and how they interact with stress-responsive signalling pathways including the heat shock factor (HSF) pathway will be reviewed. HSPs have been connected to a variety of physiological processes outside of their typical tasks, such as modulation of apoptosis, cell cycle regulation, immunological responses, and neuroprotection. The evolving functions of HSPs in these processes and their effects on human health and disease will be examined in this review. Targeting HSPs in various clinical states may also have therapeutic benefits, which will be investigated. Notably, HSPs have been suggested as therapeutic targets for diseases associated with protein misfolding, cancer, and neurodegenerative disorders. In summary, this examination will provide you a thorough understanding of the diverse functions that heat shock proteins play in cellular physiology and stress response. The investigation of their roles in various cellular functions and their therapeutic potential highlights the significance of more study in this area to develop novel therapeutic interventions and approaches for managing human health and disease.

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"THE ROLE OF SPHINGOLIPIDS IN STRESS RESPONSES AND APOPTOSIS IN EUKARYOTES." In Signalling Pathways in Apoptosis. CRC Press, 1999. http://dx.doi.org/10.1201/9781482298215-11.

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Teotia, Varsha, Jessica Pantuczek, Waseem Bashir Valiya Kalladi, John J. Murphy, and Kalpana Surendranath. "DNA Replication Stress and the Human Genome: Hurdles, Hijacks and Cell Health." In Biochemistry. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.115004.

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During replication of the genetic material, cells often face hurdles that challenge DNA replication machinery, leading to replication stress. Multiple complex signalling pathways have evolved to counteract and overcome such challenges. However, DNA repair defects caused by inefficient functioning of the DNA damage response pathways (DDR) drive genomic instability, one of the hallmarks of cancer. Here, we review the known events in DNA replication that induce replication stress and the mechanisms deployed by DDR pathways to deal with and overcome replication stress. Since the defects in these molecular pathways are associated with tumour progression, we provide an update on the novel and promising druggable targets emerging from DDR pathways. Further, we discuss how viruses replicate their DNA by hijacking and exploiting the DDR pathways and the potential to target replication stress-associated molecules for the identification of new anticancer molecules.

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Matata, Bashir M., and Maqsood M. Elahi. "Redox Signaling, Oxidative Stress in Cardiovascular Disease –basic Science and Clinical Aspects." In Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815165012123010004.

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The generation of certain species of biomolecules described as reactive oxidant species (ROS e.g., superoxide, O2 -; hydrogen peroxide, H2O2; hydroxyl radicals (OH.)) and reactive nitrogen species (RNS e.g., peroxynitrite, OONO-; nitric oxide, •NO) is a critical step in health and disease . These species play critical roles in cell defences in both animals, and plants. They also perform an important function in the regulation of key cellular signalling pathways such as cell differentiation, proliferation, migration, and apoptosis (commonly described as redox signalling pathways). The imbalance between the levels of ROS and RNS generated to that of antioxidant species may lead to oxidative stress and biomolecular damage, especially in situations where the latter are depleted. Redox biology and oxidative stress are particularly important in ischaemia-reperfusion associated diseases in particular the pathogenesis of cardiovascular disease (CVD). CVD is a major cause of mortality on a global scale, although the exact mechanisms underlying the pathological process are not fully understood. It is believed that ROS play a pivotal role in the progression of CVD. In particular, recent evidence suggests that the development of atherosclerosis is modulated by ROS and influenced by other factors such as inflammatory responses, disturbed blood flow, and arterial wall remodelling. This chapter provides an overview of the pathways of oxidative stress and redox-regulated signalling underlying the genesis and progression of cardiovascular disease.

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Conference papers on the topic "Stress signalling pathway"

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Teo, Soo Kng, Kim Parker, and K. H. Chiam. "Viscoelastic Finite-Element Modelling of Cell Deformation in an Optical Stretcher." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176085.

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In this paper, we discuss the results arising from using a finite-element model [1] of cell deformation to study the optical stretching [2,3] of normal and malignantly transformed fibroblast cells. The key feature of our model is the use of a constitutive viscoelastic fluid element [4] whose parameters are both spatially and temporally varying so as to mimic the experimentally-observed spatiotemporal heterogeneity of cellular material properties. First, we show that normal fibroblast cells can undergo active cellular response by increasing their cellular viscosity when optically stretched for

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Reports on the topic "Stress signalling pathway"

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Miller, Gad, and Jeffrey F. Harper. Pollen fertility and the role of ROS and Ca signaling in heat stress tolerance. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7598150.bard.

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The long-term goal of this research is to understand how pollen cope with stress, and identify genes that can be manipulated in crop plants to improve reproductive success during heat stress. The specific aims were to: 1) Compare heat stress dependent changes in gene expression between wild type pollen, and mutants in which pollen are heat sensitive (cngc16) or heat tolerant (apx2-1). 2) Compare cngc16 and apx2 mutants for differences in heat-stress triggered changes in ROS, cNMP, and Ca²⁺ transients. 3) Expand a mutant screen for pollen with increased or decreased thermo-tolerance. These aims

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