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Dissertations / Theses on the topic 'Stress response'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Silva, Sara Maria Cunha Oliveira. "Stress response of Listeria monocytogenes." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12617.

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Mestrado em Biologia Molecular e Celular<br>Thirty-five Listeria monocytogenes isolates previously collected from food (n=20) and human patients suffering from listeriosis (n=15), with different antibiotic resistance profiles were characterized and compared based on: (i) their ability to survive through sequential conditions that parallel the digestive tract; (ii) their capacity to survive extreme pH values; (iii) the potential relationship, between antibiotic resistance and the resistance of L. monocytogenes isolates to the stress conditions investigated. The response was shown to be strain-

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2

Di, Paolo Tiziano. "Stress response in Entamoeba histolytica." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68169.

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The heat shock response was studied in the intestinal parasitic protozoan Entamoeba histolytica. Temperature shifts from 37$ sp circ$C to 44$ sp circ$C enhanced the synthesis of five major heat shock (or stress) proteins (HSP) of 100, 50, 42, 37, and 28 kDa. Similarly, exposure of amebae to lymphokine activated macrophages and hydrogen peroxide caused HSP expression. Heat shock caused the reversible inhibition of amebic adherence to Chinese hamster ovary cells and human colonic mucin binding to trophozoites by ${>80 %}$. This was due to a decrease in the surface expression of the Gal/GalNAc ad

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3

Brorsson, Camilla. "Trauma - logistics and stress response." Doctoral thesis, Umeå universitet, Anestesiologi och intensivvård, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-93324.

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Background: Trauma is a major cause of death and disability. Adverse events, such as prolonged prehospital time, hypoxia, hypotension and/or hyperventilation have been reported to correlate to poor outcome. Adequate cortisol levels are essential for survival after major trauma. In hypotensive critically ill patients, lack of sufficient amount of cortisol can be suspected, and a concept of critical illness related corticosteroid insufficiency has been proposed. Corticosteroid therapy has many adverse effects in critically ill patients and should only be given if life-saving. Correct measurement

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4

GUCCINI, ILARIA. "Frataxin and the stress response." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/202279.

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La frataxina è una proteina mitocondriale, la cui ridotta espressione è responsabile di una malattia neurodegenerativa ereditaria, l’atassia di Friedreich (FRDA). La frataxina è una proteina che lega il ferro ed è coinvolta nella biogenesi dei gruppi ferro-zolfo (ISC), gruppi prostetici che svolgono funzioni cellulari essenziali come la fosforilazione ossidativa, la catalisi enzimatica e regolazione dei geni. La frataxina è richiesta per lo sviluppo, poiché la sua assenza è letale in embrioni di topo e provoca l’arresto nello sviluppo del nematode C. elegans. Una parziale espressione della fra

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5

Chen, Chun-Chun. "Response to social stress : sensory input, stress response and the neural substrates of reproductive suppression /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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6

Lindahl, Andreas. "Neuroendocrine Stress Response after Burn Trauma." Doctoral thesis, Uppsala universitet, Plastikkirurgi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198466.

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Some aspects of the stress response during acute intensive care for severe burns are described and quantified by measuring hormonal and neuroendocrine patterns and relating these to organ function in the short term. This includes an assessment of whether there are markers for the severity of stress that are better than conventional descriptors of the severity of a burn in predicting failing organ function. P-CgA after a major burn injury is an independent and better predictor of organ dysfunction assessed as SOFA score than the traditionally used TBSA% burned. The results also suggest that the

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7

Löw, Christian Frank. "Regulation of the cytosolic stress response." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168322.

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The cytosolic stress response, also known as the heat-shock response (HSR), is one of the major defense mechanisms activated by cells to maintain the integrity of the cellular proteome under proteotoxic environmental conditions. It is characterized by the increased synthesis of heat-shock proteins (Hsps), mainly molecular chaperones and proteases which prevent the aggregation of misfolded proteins and mediate their refolding or degradation. It is generally accepted that the induction of the HSR is coordinated by the heat-shock transcription factor 1 (HSF1). However, many mechanistic aspects of

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8

Ibrahim, Yasser Musa. "Stress response proteins in Streptococcus pneumoniae." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412962.

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9

Vine, Claire Elizabeth. "Escherichia coli response to nitrosative stress." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3544/.

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Previous transcriptomic experiments have revealed that various Escherichia coli K-12 genes encoding proteins of unknown function are highly expressed during anaerobic growth in the presence of nitrate, or especially nitrite. Products of some of these genes, especially YeaR-YoaG, YgbA, YibIH and the hybrid cluster protein, Hcp, have been implicated in the response to nitrosative stress. The aims of this study were to investigate sources of nitrosative stress, and the possible roles of some of these proteins in protection against nitric oxide. The YtfE protein has been implicated in the repair o

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10

Branco, Ricardo Garcia. "Stress response in critically ill children." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609718.

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11

Santos, Sofia Alexandra Duque. "The Stress response in transthyretin amyloidosis." Doctoral thesis, Universidade do Porto. Reitoria, 2005. http://hdl.handle.net/10216/10615.

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12

Honório, Filipe Manuel Ramalhete. "Aeromonas proteome in response to stress." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/9890.

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Mestrado em Microbiologia<br>O género Aeromonas é frequentemente associado a uma distribuição ampla no meio ambiente, emergindo como importantes patogénicos de seres humanos. No entanto, a complexidade dos mecanismos de patogenicidade permanece desconhecida e nenhum factor de virulência foi até hoje identificado individualmente como responsável pela patogenicidade. Vários factores de virulência bacteriana podem sofrer uma regulação ambiental por meio de diversos factores abióticos, permitindo a bactérias patogénicas coordenarem a expressão de factores de virulência com a existência de c

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13

Gage, Katherine Highstreet Matt Del Cid Liz. "Two-material cylinder stress response software /." Click here to view, 2009. http://digitalcommons.calpoly.edu/mesp/6.

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Thesis (B.S.)--California Polytechnic State University, 2009.<br>Project advisor: Lee McFarland. Title from PDF title page; viewed on Jan. 13, 2010. Includes bibliographical references. Also available on microfiche.

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14

Converse, Brett Michael. "Stress response in vapor phase biofilters /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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15

Crowley, Cara Leilani. "Bile salt induced stress response pathways." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289231.

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Our lab has shown that the bile salt found in the highest concentration in human fecal water, sodium deoxycholate, induces apoptosis in several cell types including Jurkat cells as well as human colonic epithelial cells. We have also found that cells within the normal appearing flat mucosa of patients with a history of colon cancer are relatively resistant to apoptosis induced by NaDOC. The current studies test the hypothesis that sodium deoxycholate induces multiple stress response pathway s that protect against apoptosis. I have tested this hypothesis by developing and analyzing cell lines t

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16

Cakir, Abdullah. "STRESS RESPONSE OF STATIC PARTICULATE MEDIA." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/dissertations/369.

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The mechanical properties of granular media are investigated using large-scale computer simulations. We probe the relationship between structural and mechanical properties in static, three dimensional granular packings through the development of a coarse graining procedure that connects the microscopic grain scale properties and a macroscopic continuum level description. We study the manner in which local stresses are redistributed in response to localized force perturbations. We first study stress response in frictionless and frictional shallow, ordered, granular arrays confined by sol

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17

Santos, Sofia Alexandra Duque. "The Stress response in transthyretin amyloidosis." Tese, Universidade do Porto. Reitoria, 2005. http://hdl.handle.net/10216/10615.

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18

Shinka, Yasuhiro. "Studies on the Oxidative Stress and Heat Stress Response Systems in a Hyperthermophilic Archaeon." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/57284.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第13852号<br>工博第2956号<br>新制||工||1436(附属図書館)<br>26068<br>UT51-2008-C768<br>京都大学大学院工学研究科合成・生物化学専攻<br>(主査)教授今中忠行, 教授青山安宏, 教授森泰生<br>学位規則第4条第1項該当

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19

Buske-Kirschbaum, Angelika. "Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135731.

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Allergic manifestations are increasingly common in infants and children. Accumulating evidence suggests that the ‘epidemic’ increase of childhood allergy may be associated with environmental factors such as stress. Although the impact of stress on the manifestation and exacerbation of allergy has been demonstrated, the underlying mechanisms of stress-induced exacerbation are still obscure. A growing number of studies have suggested an altered hypothalamus-pituitary-adrenal (HPA) axis function to stress in allergic children. It is speculated that a dysfunctional HPA axis in response to stress m

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Buske-Kirschbaum, Angelika. "Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response." Karger, 2009. https://tud.qucosa.de/id/qucosa%3A27671.

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Allergic manifestations are increasingly common in infants and children. Accumulating evidence suggests that the ‘epidemic’ increase of childhood allergy may be associated with environmental factors such as stress. Although the impact of stress on the manifestation and exacerbation of allergy has been demonstrated, the underlying mechanisms of stress-induced exacerbation are still obscure. A growing number of studies have suggested an altered hypothalamus-pituitary-adrenal (HPA) axis function to stress in allergic children. It is speculated that a dysfunctional HPA axis in response to stress m

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21

Fung, Gabriel. "Interplay between stress granules, cellular stress response, and coxsackievirus B3 infection." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58510.

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Viral infection affects a multitude of cellular processes to facilitate successful replication. Such responses include the formation of stress granules (SGs) and the activation of autophagy. SGs are stalled translational complexes and function to restore cellular homeostasis after stress. Autophagy is a cellular process that recycles misfolded proteins and damaged organelles and plays an important role in various stress responses. We previously demonstrated that infection with Coxsackievirus B3 (CVB3), a common human pathogen for viral myocarditis, disrupts the autophagic process to support ef

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22

Sasitharan, Sabanayagam. "Stress path dependency of dilatancy and stress-strain response of sand." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27998.

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The drained loading behaviour of water pluviated Erksak sand is investigated in the triaxial apparatus by varying consolidation history, stress path and loading direction (compression or extension). It is shown that, under identical minor effective principal stress, anisotropically consolidated sand has a higher tangent modulus than the isotropically consolidated sand in the initial stages of the shearing phase. This difference in the tangent modulus reduces as the sand approaches failure. The modified hyperbolic model, in which the increment in the deviator stress after consolidation is cons

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23

Andrade, Lara Filipe Rocha. "Hereditary hemochromatosis: cellular response to oxidative stress." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12495.

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Mestrado em Bioquímica - Bioquímica Clínica<br>Iron is a key element for basic cellular functions. If iron homeostasis is not maintained it may lead to iron overload. Patients with Hereditary Hemochromatosis (HH) and with the C282Y HFE mutation have a progressive severe iron overload that, if it is not treated, may lead to tissue damage, that mostly culminate in hepatic cirrhosis and carcinoma. Having in mind that tissue damage in HH may be related with oxidative stress (OS) caused by iron toxicity, it is important to understand in what way the OS defense is acting in cells from HH patients wi

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24

Weber, Barbara. "Stress response and virulence in Vibrio anguillarum." Doctoral thesis, Umeå : Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), Umeå universitet, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33269.

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25

Schultz, Evelyn. "Stress response syndrome in first-episode schizophrenia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0025/MQ50445.pdf.

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26

Lewis, Claire. "Extracytoplasmic stress response systems in S. Typhimurium." Thesis, Thesis restricted. Connect to e-thesis to view abstract, 2008. http://theses.gla.ac.uk/362/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, 2007. Includes bibliographical references. Print version also available.

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27

Clark, Leann Francis. "Response of Salmonella to food related stress." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520599.

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28

Nadarajah, Kalaivani. "Regulation of stress response in Arabidopsis thaliana." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301940.

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29

Flatley, Janet. "Response of Escherichia coli to nitrosative stress." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419666.

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30

Brearley, Jacqueline Chryscillian. "Aspects of the stress response in cattle." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293783.

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31

Wang, Jing. "Response to nitrosative stress of Escherichia coli." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6277/.

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\(Escherichia\) \(coli\) encounters nitrosative stress from various sources. It was shown in a previous study that a possible role for Hcp in the nitrosative stress response. The focus of this study was to determine the function of Hcp. The growth of the \(hcp\) mutant lacking all known NO reductases was inhibited by various sources of nitrosative stres. The growth defect was complemented by native Hcp protein, but not by mutated Hcp protein with a disrupted hybrid cluster. The role of Hcp was shown to protect \(E\). \(coli\) from nitrosative stress, and the hybrid cluster is critical for its

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32

Tekolo, Obakeng McDonald. "The osmotic stress response of basidiomycetous yeasts." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/18703.

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Thesis (MSc)--University of Stellenbosch, 2007.<br>ENGLISH ABSTRACT: Basidiomycetous yeasts are found in a wide range of geographical areas ranging from tropical forests to desert regions. These yeasts are associated with different habitats such as soil, decaying vegetative debris, living plants and animals. Some may even be opportunistic human pathogens. In most of these habitats the yeasts may periodically be exposed to adverse conditions such as osmotic stress. Forty-one basidiomycetous yeast strains obtained from culture collections and isolated from nature were studied using various metho

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Pauw, Marina. "Chitin synthesis in response to environmental stress." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86435.

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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Previous studies have indicated that fermentation with yeast strains whose cell walls contain higher chitin levels may lead to reduced wine haze formation. In order to adjust cell wall chitin levels, more information on the regulation of chitin synthesis in wine-relevant yeast is required. Yeast cells are known to increase chitin levels when subjected to certain environmental changes such as an increase in temperature. The main aim of this project was to investigate chitin accumulation and synthesis in wine yeast strains when ex

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34

Honn, Marie. "The oxidative stress response of Francisella tularensis." Doctoral thesis, Umeå universitet, Klinisk bakteriologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-115635.

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Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. ROS interact with and disrupt the function of vital molecules such as DNA, proteins and bacterial structures. Iron potentiates the danger of ROS through the Fenton reaction where ferrous iron reduces H2O2 causing the formation of highly reactive hydroxyl radicals and anions. Low

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35

Hashimoto, Hisashi. "STUDIES ON STRESS RESPONSE OF FISH CELLS." Kyoto University, 1998. http://hdl.handle.net/2433/157119.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第7412号<br>農博第996号<br>新制||農||763(附属図書館)<br>学位論文||H10||N3158(農学部図書室)<br>UT51-98-G341<br>京都大学大学院農学研究科水産学専攻<br>(主査)教授坂口守彦, 教授内田有恆, 教授宮本元<br>学位規則第4条第1項該当

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36

Krishnan, Arjun. "Systems analysis of stress response in plants." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77221.

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The response of plants to environmental stress spans several orders of magnitude in time and space, causing system-wide changes. These changes comprise of both protective responses and adverse reactions in the plant. Stresses like water deficit or drought cause a drastic effect in crop yield, while concomitantly agriculture consumes 1/3rd of the fresh water available to us and there is widespread water scarcity around the world. It is, hence, a fundamental goal of modern biology and applied biotechnology to unravel this complex stress response in laboratory model plants like Arabidopsis and cr

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Szivak, Tunde K. "Warfighter Adrenal Response to Extreme Military Stress." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469158477.

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38

Lindqvist, Anton. "Stress Response Analysis Using Centralised Expression Data." Thesis, Umeå universitet, Institutionen för fysik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177326.

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Background: The last two decades have seen several new methods for analysing gene expression data. One such method is pathway analysis in which it’s possible to decipher response patterns between pathways (groups of interacting genes) and external stress factors. A critical issue in pathway analysis is often limited sample sizes resulting in undesirable batch affects. A method for reducing such effects, called Centralization Within Sub-Experiments (CSE), has recently been developed. This method makes it possible to predict pathways using data from experiments with a diversity of external condi

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39

Day, Andrew R. "The stress response in laparoscopic colorectal surgery." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/808194/.

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Introduction Laparoscopic colorectal surgery and enhanced recovery programs have been shown to improve patient outcomes and reduce length of stay following surgery. The use of regional analgesia is usually a fundamental element of an enhanced recovery program. A proposed benefit of regional analgesia in colorectal surgery is suppression of the post-operative stress response. No data is available to indicate if this is applicable in laparoscopic colorectal surgery. In addition there is no direct evidence addressing whether there is an appropriate type of fluid, crystalloid or colloid, to use in

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Alsharif, Sultan M. M. "Stress response and pathogenicity in Streptococcus pneumoniae." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5231/.

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The pathogen Streptococcus pneumoniae encounters different levels of oxygen during the infection cycle including colonisation, pneumonia, bateraemia and meningitis. These different anatomical niches require high levels of genome changes to sense and respond to those external environmental stimuli. The bacterial gene expression is known to be affected by oxygen, and it must react properly for survival and for developing invasive pneumococcal desiseases (IPDs). Microarray techniques have allowed scanning the whole pneumococcal genome during growth in different tensions of oxygen mimicking in viv

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Li, Ying. "Metabolic Plasticity in the Cellular Stress Response." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3467.

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Changes to the metabolism of the cardiomyocyte are driven by complex signaling pathways in order to adjust to stress. For instance, HIF-1α is classically known to upregulate glycolytic metabolism to compensate for oxygen deficiency. Other important effects upon glucose metabolism, which we investigate here more extensively, were also observed. Hearts derived from mice with the cardiac-restricted expression of a stabilized form of HIF-1α are remarkably ischemia stress-tolerant. Here, stable isotope-resolved metabolomic analyses were utilized to investigate glucose cardiometabolism remodeling by

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Mohd, Najib Mohd Idris. "Characterisation of THOC4 response to replicative stress." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122562/1/Mohd%20Idris_Mohd%20Najib_Thesis.pdf.

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Human cells are continuously subject to conditions that cause breaks to DNA. This project explored the interaction between molecules involved in repairing this damage, called hSSB1 and THOC4. Novel discoveries were made that expand our understanding of this important process and identified THOC4 as a potential novel therapeutic target in lung and breast cancer.

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McDonald-Morken, Colleen Ann. "Hawk and Dove Stress Response Profiles in Humans." Thesis, North Dakota State University, 2011. https://hdl.handle.net/10365/29861.

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A recent evolutionary theory hypothesizes that there are two primary biobehavioral profiles of stress responding. Labeled "hawk" and "dove," each is characterized by divergent patterns of autonomic nervous system and neuroendocrine system activations in response to stress as well as distinct affective and behavioral tendencies. These profiles are prominent in a number of species, and it has been hypothesized that hawk-like and dovelike responses to stress may, in part, explain variability in stress-related health outcomes. This study is a preliminary investigation of hawk and dove biobehaviora

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James, Andrew Thomas. "Genotypic variation in soybean for drought stress response /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17408.pdf.

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Bouman, Lena. "A role of parkin in stress response pathways." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-120918.

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Gonzalez, Angel Ana Maria. "Porites astreoides Larval Response to Acute Salinity Stress." NSUWorks, 2013. http://nsuworks.nova.edu/occ_stuetd/178.

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Coral reef biodiversity is threatened by rapidly changing anthropogenic activities and natural perturbations, leading to massive ecological and economic consequences ranging from the loss of fisheries to coastal erosion. It is necessary to understand corals responses to environmental changes in order to determine management programs on appropriate spatial and temporal scales to address these issues. Coral larvae are the product of sexual reproduction, have the potential to recruit to new areas, and are fundamental in maintaining genetic diversity. These larvae are subjected to variations in lo

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Xavier, Ilungo Johnny. "Environmental stress response of the hyphomycetous entomopathogenic fungi." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ32803.pdf.

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48

Calara, Federico Ben. "The vascular response to oxidative and mechanical stress /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980924cala.

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49

Al-Tabbaa, A. "Permeability and stress-strain response of speswhite kaolin." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382516.

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50

Haque, Mainul. "Mathematical modelling of eukaryotic stress-response gene networks." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12509/.

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Abstract:

Mathematical modelling of gene regulatory networks is a relatively new area which is playing an important role in theoretical and experimental investigations that seek to open the door to understanding the real mechanisms that take place in living systems. The current thesis concentrates on studying the animal stress-response gene regulatory network by seeking to predict the consequence of environmental hazards caused by chemical mixtures (typical of industrial pollution). Organisms exposed to pollutants display multiple defensive stress responses, which together constitute an interlinked gene

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