Journal articles on the topic 'Stress modulation'

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1

Akirav, Irit, and Mouna Maroun. "Stress modulation of reconsolidation." Psychopharmacology 226, no. 4 (October 6, 2012): 747–61. http://dx.doi.org/10.1007/s00213-012-2887-6.

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2

Sameena, T., and S. Pranesh. "Synchronous and Asynchronous Boundary Temperature Modulations on Triple-Diffusive Convection in Couple Stress Liquid Using Ginzburg-Landau Model." International Journal of Engineering & Technology 7, no. 4.10 (October 2, 2018): 645. http://dx.doi.org/10.14419/ijet.v7i4.10.21304.

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A nonlinear study of synchronous and asynchronous boundary temperature modulations on the onset of triple-diffusive convection in couple stress liquid is examined. Two cases of temperature modulations are studied: (a) Synchronous temperature modulation ( ) and (b) Asynchronous temperature modulation ( ). It is done to examine the influence of mass and heat transfer by deriving Ginzburg-Landau equation. The resultant Ginzburg-Landau equation is Bernoulli equation and it is solved numerically by means of Mathematica. The influence of solute Rayleigh numbers and couple stress parameter is studied. It is observed that couple stress parameter increases the mass and heat transfer whereas solute Rayleigh numbers decreases the mass and heat transfer.
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3

Valiente-Echeverría, Fernando, Luca Melnychuk, and Andrew J. Mouland. "Viral modulation of stress granules." Virus Research 169, no. 2 (November 2012): 430–37. http://dx.doi.org/10.1016/j.virusres.2012.06.004.

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4

Colzato, Lorenza S., Wouter Kool, and Bernhard Hommel. "Stress modulation of visuomotor binding." Neuropsychologia 46, no. 5 (2008): 1542–48. http://dx.doi.org/10.1016/j.neuropsychologia.2008.01.006.

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5

DeVries, A. Courtney, Erica R. Glasper, and Courtney E. Detillion. "Social modulation of stress responses." Physiology & Behavior 79, no. 3 (August 2003): 399–407. http://dx.doi.org/10.1016/s0031-9384(03)00152-5.

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Zhai, Xiaojing, Dongyu Zhou, Yi Han, Ming-Hu Han, and Hongxing Zhang. "Noradrenergic modulation of stress resilience." Pharmacological Research 187 (January 2023): 106598. http://dx.doi.org/10.1016/j.phrs.2022.106598.

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7

Piterková, J., L. Luhová, L. Zajoncová, M. Šebela, and M. Petřivalský. "Modulation of polyamine catabolism in pea seedlings by calcium during salinity stress." Plant Protection Science 48, No. 2 (May 3, 2012): 53–64. http://dx.doi.org/10.17221/62/2011-pps.

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The relation of polyamine catabolism in the response of Pisum sativum to salinity stress was investigated. Pea seedlings were grown in increasing concentrations of Na<sup>+</sup> or K<sup>+</sup> or at different concentration ratios of these ions. We studied the effect of Ca<sup>2+</sup> supplementation on plants exposed to salinity stress. The parameters measured in the roots and shoots of pea seedlings included biomass production, levels of Na<sup>+</sup>, K<sup>+</sup>, Ca<sup>2+</sup> and polyamines and activity of enzymes of polyamine catabolism: diamine oxidase, aminoaldehyde dehydrogenase and peroxidases. Salinity induced increased polyamine levels and higher activity of enzymes participating in polyamine degradation. Supplementation of Ca<sup>2+</sup> had a positive effect on biomass production and in most cases it stabilised both the polyamine level and the activity of the studied enzymes. Our results confirm the role of aminoaldehyde dehydrogenase and polyamine catabolism in defence mechanisms of pea plants under salinity stress.
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8

Carlesi, C., E. Caldarazzo Ienco, S. Piazza, A. Lo Gerfo, R. Alessi, L. Pasquali, and Gabriele Siciliano. "Oxidative stress modulation in neurodegenerative diseases." Mediterranean Journal of Nutrition and Metabolism 4, no. 3 (February 5, 2011): 219–25. http://dx.doi.org/10.3233/s12349-011-0053-z.

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9

Beltran, Michael J., Cory A. Collinge, and Michael J. Gardner. "Stress Modulation of Fracture Fixation Implants." Journal of the American Academy of Orthopaedic Surgeons 24, no. 10 (October 2016): 711–19. http://dx.doi.org/10.5435/jaaos-d-15-00175.

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10

Zima, Tom??&OV0165;, Emanuele Albano, Magnus Ingelman-Sundberg, Gavin E. Arteel, Geoffrey M. Thiele, Lynell W. Klassen, and Albert Y. Sun. "Modulation of Oxidative Stress by Alcohol." Alcoholism: Clinical & Experimental Research 29, no. 6 (June 2005): 1060–65. http://dx.doi.org/10.1097/01.alc.0000168168.43419.54.

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11

Carlesi, C., E. Caldarazzo Ienco, S. Piazza, A. Lo Gerfo, R. Alessi, L. Pasquali, and Gabriele Siciliano. "Oxidative stress modulation in neurodegenerative diseases." Mediterranean Journal of Nutrition and Metabolism 4, no. 3 (February 5, 2011): 219–25. http://dx.doi.org/10.1007/s12349-011-0053-z.

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12

VINAYAGAMOORTHY, T., and A. R. J. RAJAKUMAR. "Stress Relief Protein Modulation by Calnexin." Annals of the New York Academy of Sciences 793, no. 1 Myocardial Pr (September 1996): 479–84. http://dx.doi.org/10.1111/j.1749-6632.1996.tb33545.x.

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13

Beltowski, Jerzy. "Statins and Modulation of Oxidative Stress." Toxicology Mechanisms and Methods 15, no. 2 (January 2005): 61–92. http://dx.doi.org/10.1080/15376520590918766.

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14

Da Costa, Laura A., Alaa Badawi, and Ahmed El-Sohemy. "Nutrigenetics and Modulation of Oxidative Stress." Annals of Nutrition and Metabolism 60, s3 (2012): 27–36. http://dx.doi.org/10.1159/000337311.

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15

Tort, Lluis. "Stress and immune modulation in fish." Developmental & Comparative Immunology 35, no. 12 (December 2011): 1366–75. http://dx.doi.org/10.1016/j.dci.2011.07.002.

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16

Alamdari, Daryoush Hamidi, Malektaj Honarmand, Abdolfattah Sarrafnejad, Abdolreza Varasteh, Mohammad Reza Parizadeh, Majid Ghayour-Mobarhan, Daryoush Fahimi, Elena Kostidou, Apostolos I. Hatzitolios, and George Koliakos. "Oxidative Stress Modulation Immediately After Hemodialysis." Dialysis & Transplantation 38, no. 9 (September 2009): 354–58. http://dx.doi.org/10.1002/dat.20345.

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17

Kitazumi, Ai, Yoshihiro Kawahara, Ty S. Onda, David De Koeyer, and Benildo G. de los Reyes. "Implications of miR166 and miR159 induction to the basal response mechanisms of an andigena potato (Solanum tuberosum subsp. andigena) to salinity stress, predicted from network models in Arabidopsis." Genome 58, no. 1 (January 2015): 13–24. http://dx.doi.org/10.1139/gen-2015-0011.

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MicroRNA (miRNA) mediated changes in gene expression by post-transcriptional modulation of major regulatory transcription factors is a potent mechanism for integrating growth and stress-related responses. Exotic plants including many traditional varieties of Andean potatoes (Solanum tuberosum subsp. andigena) are known for better adaptation to marginal environments. Stress physiological studies confirmed earlier reports on the salinity tolerance potentials of certain andigena cultivars. Guided by the hypothesis that certain miRNAs play important roles in growth modulation under suboptimal conditions, we identified and characterized salinity stress-responsive miRNA-target gene pairs in the andigena cultivar Sullu by parallel analysis of noncoding and coding RNA transcriptomes. Inverse relationships were established by the reverse co-expression between two salinity stress-regulated miRNAs (miR166, miR159) and their target transcriptional regulators HD-ZIP-Phabulosa/Phavulota and Myb101, respectively. Based on heterologous models in Arabidopsis, the miR166–HD-ZIP-Phabulosa/Phavulota network appears to be involved in modulating growth perhaps by mediating vegetative dormancy, with linkages to defense-related pathways. The miR159–Myb101 network may be important for the modulation of vegetative growth while also controlling stress-induced premature transition to reproductive phase. We postulate that the induction of miR166 and miR159 under salinity stress represents important network hubs for balancing gene expression required for basal growth adjustments.
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18

Cheng, Chia-Yi, and Jung-Nung Chang. "Job embeddedness as a modulation." Journal of Organizational Change Management 29, no. 4 (July 4, 2016): 484–507. http://dx.doi.org/10.1108/jocm-10-2014-0184.

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Purpose – Based on job embeddedness (JE) theory, the purpose of this paper is to explore the impact of goal orientation (GO) and JE on job stress for financial service salespersons in the indeterminate situation. Design/methodology/approach – Participants were 298 insurance salespersons employed at two major life insurance institutions in Taiwan: Nan Shan and Fubon – which were formerly the subsidiaries of two international financial groups, American International Group and International Netherland Group, respectively. The models were tested using the two-step structural equation procedure. Findings – Findings indicated that, compared with salespersons in the newly merged Fubon, those in Nan Shan, which was undergoing mergers and acquisitions, were found to be subject to higher job stress with lower JE. In the process of reducing stress, JE is an important mechanism. However, the modulating influence of embeddedness is dependent on salespersons’ GO. In situations of higher stress, learning-oriented salespersons (in Nan Shan) were unable to significantly reduce job stress until JE was introduced as a full mediator. However, in a lower stress context, performance-oriented salespersons (in Fubon) fully applied JE in order to relieve job stress. Research limitations/implications – Managers endeavor to help salespersons effectively improve stability and reduce job stress by exploiting salespersons’ dispositions. Originality/value – The contribution of this study includes identifying the role of JE on the relationship between GO and job stress for the contingency of an indeterminate state.
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19

Seo, Deok Hyun, Subhin Seomun, Yang Do Choi, and Geupil Jang. "Root Development and Stress Tolerance in rice: The Key to Improving Stress Tolerance without Yield Penalties." International Journal of Molecular Sciences 21, no. 5 (March 6, 2020): 1807. http://dx.doi.org/10.3390/ijms21051807.

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Roots anchor plants and take up water and nutrients from the soil; therefore, root development strongly affects plant growth and productivity. Moreover, increasing evidence indicates that root development is deeply involved in plant tolerance to abiotic stresses such as drought and salinity. These findings suggest that modulating root growth and development provides a potentially useful approach to improve plant abiotic stress tolerance. Such targeted approaches may avoid the yield penalties that result from growth–defense trade-offs produced by global induction of defenses against abiotic stresses. This review summarizes the developmental mechanisms underlying root development and discusses recent studies about modulation of root growth and stress tolerance in rice.
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20

Guzmán, Pablo, Nimrod Vázquez, Marco Liserre, Rodolfo Orosco, Sergio Enrique Pinto Castillo, and Claudia Hernández. "Two-Stage Modulation Study for DAB Converter." Electronics 10, no. 21 (October 20, 2021): 2561. http://dx.doi.org/10.3390/electronics10212561.

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The dual active bridge (DAB) is a dc/dc converter frequently employed in multiple applications due to its advantages of isolation, power flexibility, and input and output voltage defined by design. Different multi-phase modulations have been reported to increase DAB efficiency and reduce components stress but, certainly, the control and implementation complexity increases with every displacement angle added because of the multiple variable measurements. This paper presents two-stage modulations based on the single phase-shift (SPS), which allows maintaining simplicity while improving the efficiency of the DAB converter depending on the design conditions. The paper also gives a direction for selecting the proper modulation to achieve the best efficiency for each situation. The different two-stage modulations are described, analyzed, and experimentally tested.
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21

Babar, Imran A., Frank J. Slack, and Joanne B. Weidhaas. "miRNA modulation of the cellular stress response." Future Oncology 4, no. 2 (April 2008): 289–98. http://dx.doi.org/10.2217/14796694.4.2.289.

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22

Campeau, Serge, Israel Liberzon, David Morilak, and Kerry Ressler. "Stress modulation of cognitive and affective processes." Stress 14, no. 5 (July 26, 2011): 503–19. http://dx.doi.org/10.3109/10253890.2011.596864.

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23

Dixit, N. Prashanth, Vijaynath Itagi, Y. P. Raghavendra Babu, and B. S. Prakash. "Effect of Occupational Stress on Autonomic Modulation." International Journal of Physiology 5, no. 2 (2017): 163. http://dx.doi.org/10.5958/2320-608x.2017.00079.8.

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24

Boccatonda, Andrea, Romina Tripaldi, Giovanni Davì, and Francesca Santilli. "Oxidative Stress Modulation Through Habitual Physical Activity." Current Pharmaceutical Design 22, no. 24 (June 15, 2016): 3648–80. http://dx.doi.org/10.2174/1381612822666160413123806.

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25

BÖSING-SCHNEIDER, RITA. "Stress-Induced Modulation of the Immune Network." Annals of the New York Academy of Sciences 496, no. 1 Neuroimmune I (May 1987): 447–49. http://dx.doi.org/10.1111/j.1749-6632.1987.tb35800.x.

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26

HENKE, PETER G. "Limbic System Modulation of Stress Ulcer Development." Annals of the New York Academy of Sciences 597, no. 1 Neurobiology (July 1990): 201–6. http://dx.doi.org/10.1111/j.1749-6632.1990.tb16168.x.

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27

BONNEAU, ROBERT H., JANICE K. KIECOLT-GLASER, and RONALD GLASER. "Stress-Induced Modulation of the Immune Response." Annals of the New York Academy of Sciences 594, no. 1 Neuropeptides (June 1990): 253–69. http://dx.doi.org/10.1111/j.1749-6632.1990.tb40485.x.

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28

Santos, Leonardo, Carlos Escande, and Ana Denicola. "Potential Modulation of Sirtuins by Oxidative Stress." Oxidative Medicine and Cellular Longevity 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/9831825.

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Sirtuins are a conserved family of NAD-dependent protein deacylases. Initially proposed as histone deacetylases, it is now known that they act on a variety of proteins including transcription factors and metabolic enzymes, having a key role in the regulation of cellular homeostasis. Seven isoforms are identified in mammals (SIRT1–7), all of them sharing a conserved catalytic core and showing differential subcellular localization and activities. Oxidative stress can affect the activity of sirtuins at different levels: expression, posttranslational modifications, protein-protein interactions, and NAD levels. Mild oxidative stress induces the expression of sirtuins as a compensatory mechanism, while harsh or prolonged oxidant conditions result in dysfunctional modified sirtuins more prone to degradation by the proteasome. Oxidative posttranslational modifications have been identifiedin vitroandin vivo, in particular cysteine oxidation and tyrosine nitration. In addition, oxidative stress can alter the interaction with other proteins, like SIRT1 with its protein inhibitor DBC1 resulting in a net increase of deacetylase activity. In the same way, manipulation of cellular NAD levels by pharmacological inhibition of other NAD-consuming enzymes results in activation of SIRT1 and protection against obesity-related pathologies. Nevertheless, further research is needed to establish the molecular mechanisms of redox regulation of sirtuins to further design adequate pharmacological interventions.
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29

Yang, Eric V., Cynthia M. Bane, Robert C. MacCallum, Janice K. Kiecolt-Glaser, William B. Malarkey, and Ronald Glaser. "Stress-related modulation of matrix metalloproteinase expression." Journal of Neuroimmunology 133, no. 1-2 (December 2002): 144–50. http://dx.doi.org/10.1016/s0165-5728(02)00270-9.

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30

Moynihan, Jan A. "Mechanisms of stress-induced modulation of immunity." Brain, Behavior, and Immunity 17, no. 1 (February 2003): 11–16. http://dx.doi.org/10.1016/s0889-1591(02)00060-0.

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31

Larbi, Anis, Juergen Kempf, and Graham Pawelec. "Oxidative stress modulation and T cell activation." Experimental Gerontology 42, no. 9 (September 2007): 852–58. http://dx.doi.org/10.1016/j.exger.2007.05.004.

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32

Floc'h, Nicolas, Jakub Kolodziejski, Leila Akkari, Yannick Simonin, Stéphane Ansieau, Alain Puisieux, Urszula Hibner, and Patrice Lassus. "Modulation of Oxidative Stress by Twist Oncoproteins." PLoS ONE 8, no. 8 (August 13, 2013): e72490. http://dx.doi.org/10.1371/journal.pone.0072490.

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33

Sciarretta, Sebastiano, Peiyong Zhai, Massimo Volpe, and Junichi Sadoshima. "Pharmacological Modulation of Autophagy During Cardiac Stress." Journal of Cardiovascular Pharmacology 60, no. 3 (September 2012): 235–41. http://dx.doi.org/10.1097/fjc.0b013e3182575f61.

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34

Reinhardt, Tatyana, Nikolaus Kleindienst, Rolf-Detlef Treede, Martin Bohus, and Christian Schmahl. "Individual Modulation of Pain Sensitivity under Stress." Pain Medicine 14, no. 5 (May 2013): 676–85. http://dx.doi.org/10.1111/pme.12090.

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35

Sheridan, J. F. "Stress-Induced Modulation of Anti-viral Immunity." Brain, Behavior, and Immunity 12, no. 1 (March 1998): 1–6. http://dx.doi.org/10.1006/brbi.1998.0521.

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36

Dinan, Timothy G. "Vasopressin: The neglected target for stress modulation?" Stress and Health 21, no. 3 (2005): 145–46. http://dx.doi.org/10.1002/smi.1054.

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37

Loughlin, Sandra E., Michelle I. Islas, Michelle Y. Cheng, Alex G. Lee, Anne-Sophie Villegier, and Frances M. Leslie. "Nicotine modulation of stress-related peptide neurons." Journal of Comparative Neurology 497, no. 4 (2006): 575–88. http://dx.doi.org/10.1002/cne.20999.

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38

Kniazkov, A. V. "Reflective polarization-modulation method of stress estimation using stress-induced birefringence." Journal of Applied Physics 122, no. 12 (September 28, 2017): 125106. http://dx.doi.org/10.1063/1.5004642.

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39

Alexander, Jessica K., Ashleigh Hillier, Ryan M. Smith, Madalina E. Tivarus, and David Q. Beversdorf. "Beta-adrenergic Modulation of Cognitive Flexibility during Stress." Journal of Cognitive Neuroscience 19, no. 3 (March 2007): 468–78. http://dx.doi.org/10.1162/jocn.2007.19.3.468.

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Stress-induced activation of the locus ceruleus-norepinephrine (LC-NE) system produces significant cognitive and behavioral effects, including enhanced arousal and attention. Improvements in discrimination task performance and memory have been attributed to this stress response. In contrast, for other cognitive functions that require cognitive flexibility, increased activity of the LC-NE system may produce deleterious effects. The aim of the present study was to determine the effect of pharmacological modulation of the LC-NE system on stress-induced impairments in cognitive flexibility performance in healthy individuals. Cognitive performance, plus psychological and physiological parameters for 16 adults without any history of anxiety disorders, was assessed during four test sessions: stress and no-stress, with each condition tested after administration of propranolol and placebo. The Trier Social Stress Test, a public-speaking and mental arithmetic stressor, was presented to participants for the stress sessions, whereas a similar, but nonstressful, control task (reading, counting) was utilized for the no-stress sessions. Tests of cognitive flexibility included lexical-semantic and associative problem-solving tasks (anagrams, Compound Remote Associates Test). Visuo-spatial memory and motor processing speed tests served as control tasks. Results indicate that (1) stress impaired performance on cognitive flexibility tasks, but not control tasks; (2) compared to placebo, cognitive flexibility improved during stress with propranolol. Therefore, psychological stress, such as public speaking, negatively impacts performance on tasks requiring cognitive flexibility in normal individuals, and this effect is reversed by beta-adrenergic antagonism. This may provide support for the hypothesis that stress-related impairments in cognitive flexibility are related to the noradrenergic system.
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40

Klotz. "FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance." Proceedings 11, no. 1 (April 16, 2019): 11. http://dx.doi.org/10.3390/proceedings2019011011.

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FOXO (Forkhead box, class O) proteins are transcriptional regulators ubiquitously expressed in mammalian cells with roles in modulating fuel metabolism, stress resistance and cell death. FOXO transcription factors are regulated by redox processes at several levels, including enzymatic and nonenzymatic posttranslational modification. Target genes controlled by FOXO proteins include genes encoding antioxidant proteins, thus likely contributing to the key role FOXOs play in the cellular response to oxidative stress. Here, an overview is provided on (i) the modulation of FOXO proteins by thiol depleting agents, (ii) consequences of thiol depletion for stress resistance and life span of a model organism, Caenorhabditis elegans and (iii) the role of FOXO proteins therein.
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41

Brouillard, C., P. Carrive, F. Camus, J. J. Benoliel, and C. Sévoz-Couche. "Stress, anxiety and central neural modulation of cardiovascular stress response in rats." Autonomic Neuroscience 192 (November 2015): 37–38. http://dx.doi.org/10.1016/j.autneu.2015.07.370.

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42

Farooqi, Ammad Ahmad, Kun-Tzu Li, Sundas Fayyaz, Yung-Ting Chang, Muhammad Ismail, Chih-Chuang Liaw, Shyng-Shiou F. Yuan, Jen-Yang Tang, and Hsueh-Wei Chang. "Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress." Tumor Biology 36, no. 8 (July 19, 2015): 5743–52. http://dx.doi.org/10.1007/s13277-015-3797-0.

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43

Mayer, Emeran A., Bruce D. Naliboff, Lin Chang, and Santosh V. Coutinho. "V. Stress and irritable bowel syndrome." American Journal of Physiology-Gastrointestinal and Liver Physiology 280, no. 4 (April 1, 2001): G519—G524. http://dx.doi.org/10.1152/ajpgi.2001.280.4.g519.

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Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.
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44

Fernandez-García, Jose, Fernando Cardona, and Francisco Tinahones. "Inflammation, Oxidative Stress and Metabolic Syndrome: Dietary Modulation." Current Vascular Pharmacology 11, no. 6 (January 31, 2014): 906–19. http://dx.doi.org/10.2174/15701611113116660175.

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45

., Mahbub-E.-Sobhani, N. Haque, U. Salma, and A. Ahmed. "Immune Modulation in Response to Stress and Relaxation." Pakistan Journal of Biological Sciences 14, no. 6 (March 1, 2011): 363–74. http://dx.doi.org/10.3923/pjbs.2011.363.374.

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46

Arora, Sarika, and Jayashree Bhattacharjee. "Modulation of immune responses in stress by Yoga." International Journal of Yoga 1, no. 2 (2008): 45. http://dx.doi.org/10.4103/0973-6131.43541.

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47

PARROTT, ANDREW C. "Stress modulation over the day in cigarette smokers." Addiction 90, no. 2 (February 1995): 233–44. http://dx.doi.org/10.1111/j.1360-0443.1995.tb01041.x.

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48

Choudhary, Gaurav, and Samuel C. Dudley. "Heart Failure, Oxidative Stress, and Ion Channel Modulation." Congestive Heart Failure 8, no. 3 (May 2002): 148–55. http://dx.doi.org/10.1111/j.1527-5299.2002.00716.x.

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49

PARROTT, ANDREW C. "Stress modulation over the day in cigarette smokers." Addiction 90, no. 2 (January 24, 2006): 233–44. http://dx.doi.org/10.1046/j.1360-0443.1995.9022339.x.

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50

Saxena, Deepti, Sunil Khanna, and Mohammed Amin. "Modulation of protein profiles inRhizobiumsp. under salt stress." Canadian Journal of Microbiology 42, no. 6 (June 1, 1996): 617–20. http://dx.doi.org/10.1139/m96-084.

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Salinity-induced changes in the protein profiles in Rhizobium sp. exhibited alterations in the expression of as many as 19 proteins, which either showed an enhanced rate of synthesis or a decline in the levels as compared with controls. All these proteins were predominantly of low molecular mass (below 40 kDa) except for one (52 kDa). Induction and repression of proteins in salt-grown cells and salt-shocked cells were qualitatively similar. However, the difference in the protein profiles was more marked in salt-grown cells as compared with salt-shocked cells.Key words: Rhizobium, SDS–PAGE, salt stress, proteins.
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