Relevant bibliographies by topics / Streptococcus pyogenes

Academic literature on the topic 'Streptococcus pyogenes'

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Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Streptococcus pyogenes"

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Gorb, N. N., E. Yu Smertina, A. V. Merck, V. M. Sorokoletova, and M. V. Lazareva. "Resistance to antimicrobials of the microflora extracted in acute postpartum endometritis in cows." Bulletin of NSAU (Novosibirsk State Agrarian University), no. 2 (July 26, 2023): 163–69. http://dx.doi.org/10.31677/2072-6724-2023-67-2-163-169.

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In the article, the authors presented data on the species structure of the microflora isolated from cows with acute postpartum purulent-catarrhal endometritis. In acute postpartum endometritis, representatives of 8 genera of microorganisms were isolated in washings from the cervical canal. Identification of isolates to the species showed that Streptococcus pyogenes, Escherichia coli and Staphylococcus aureus were most often isolated from sick cows. These microorganisms were more common in associations: Escherichia coli + Streptococcus pyogene; Staphylococcus aureus + Streptococcus pyogenes. And Proteus vulgaris + Staphylococcus epidermidis. The disk diffusion method tested Streptococcus pyogenes, Escherichia coli and Staphylococcus aureus for resistance to 9 pharmacological groups of antimicrobial agents. In total, 48 isolates of 15 antibacterial drugs were tested in the work. The studied isolates of microorganisms showed multiple drug resistance. The authors revealed resistance to drugs of three or more pharmacological groups. Microorganisms showed high resistance (80% or more of isolates that did not show growth zone retardation) to drugs: neomycin (aminoglycosides) and benzylpenicillin (penicillins) - Staphylococcus aureus and Escherichia coli; vancomycin (glycopeptides), polymyxin (polymyxins) - Streptococcus pyogenes and Escherichia coli; ampicillin (penicillins), tetracycline (tetracyclines), cefazolin (cephalosporins), ciprofloxacin (fluoroquinolones) - only Staphylococcus aureus; lincomycin (lincosamides), tylosin (macrolides) - only Escherichia coli; streptomycin (aminoglycoside) - only Streptococcus pyogenes.
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SHEFF, BARBARA. "Streptococcus pyogenes." Nursing 32, no. 1 (January 2002): 75. http://dx.doi.org/10.1097/00152193-200201000-00068.

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S Hamim, Saad, Khwam R Hussein, and Younus Younus A Kamel. "Molecular profile of scpA and sdaB virulence genes in Streptococcus pyogenes isolated from pharyngitis." AL-QADISIYAH MEDICAL JOURNAL 13, no. 24 (December 5, 2018): 67–71. http://dx.doi.org/10.28922/qmj.2017.13.24.67-71.

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Group A Streptococci (GAS) or Streptococcus pyogenes is an important pathogen which causes a wide-ranging of diseases for human. This study was carried out in Ear Nose Throat (ENT) department in Al–Habboby Teaching Hospital, Thi-Qar province, south of Iraq during the period from October 2015 to April 2016. Two hundred and ten swabs were collected from patients infected with pharyngitis. 152 (72.3 %) showed positive growth with S. pyogenes. GAS isolates were subjected to detect two virulence genes (scpA and sdaB) by conventional PCR technique using specific primer pairs and DNA sequencing analysis. The sequencing of PCR products produced from bacterial DNA showed significant alignments identities (96-99%) to the S. pyogenes which are located in BLAST-NCBI Genbank. The six sequences of Streptococcus pyogenes scpA and sdaB genes determined in this study have been deposited in the GenBank under the accession numbers MF49318-MF497323. Phylogenetic analysis of S. pyogenes based upon the neighbour-joining of partial scpA and sdaB gene sequences showed that these sequences were derived from Streptococcal genes. In addition, S. pyogenes can produce several exotoxins that have the potential to damage the host tissues either directly or through the stimulation of cytokine production.
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Isnaeni, Dewi, Andi Ulfah Magefirah Rasyid, and Rahmawati Rahmawati. "Uji Aktivitas Ekstrak Daun Opo-Opo (Desmodium pulchellum Linn Benth) sebagai Antibakteri terhadap Pertumbuhan Streptococcus viridans dan Streptococcus pyogenes." Jurnal Sains dan Kesehatan 3, no. 2 (April 30, 2021): 278–89. http://dx.doi.org/10.25026/jsk.v3i2.339.

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Streptococcal tonsillopharyngitis is a type of tonsillopharyngitis caused by group A streptococcal bacterial infection with common symptoms such as sore throat, fever more than 38oC, tonsilar exudate, and cervical adenopathy. Possible complications of streptococcal tonsillopharyngitis include rheumatic fever that occurs at weeks 1-5 after acute respiratory infections by Streptococcus viridans and Streptococcus pyogenes. Treatment needs to be done This research aims to determine the value of Minimum Inhibitory Concentration (MIC) and Minimum Kill Concentration (MKC) of Opo-opo leaf extract (Desmodium pulchellum Linn Benth) on the growth of Streptococcus viridans and Streptococcus pyogenes. This research uses a maceration extraction method of the ingredients. microbiological test and test using the liquid dilution method. The extract concentration used was 0.1% w / v, 0.25% w / v, 0.5% w / v, 0.75% w / v, 1% w / v, 1.25% w / v , 1.5% w / v, 1.75% w / v, 2% w / v, 2.25% w / v, 2.5% w / v with negative control of Na, CMC 1% w / v. The test results showed that the MIC of Opo-opo leaf extract on Streptococcus viridans was 0.75%, MKC of opo-opo leaf extract on Streptococcus viridaans was 1% while the MIC of Opo-opo leaf extract on Streptococcus pyogenes was 0.25% and the MKC of leaf extract. Opo-opo in Streptococcus pyogenes is 1%. The results of the phytochemical screening of Opo-opo leaf extract (Desmodium pulchellum Linn Benth) were positive for alkaloids, flavonoids, tannins and terpenoids.
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Komala Hadi, Debbie Rose. "Spektrum Klinis Infeksi Streptococcus Grup A pada Anak." Cermin Dunia Kedokteran 50, no. 11 (November 1, 2023): 627–31. http://dx.doi.org/10.55175/cdk.v50i11.1009.

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Streptococcus Grup A (SGA) atau Streptococcus pyogenes, merupakan bakteri yang sering menyebabkan infeksi saluran napas dan infeksi kulit pada anak. Organisme ini juga dapat menimbulkan infeksi invasif, yaitu sindrom syok toksik streptococcal dan necrotizing fasciitis; serta berbagai komplikasi dan sekuele, di antaranya demam rematik akut, glomerulonefritis akut pasca-Streptococcus, artritis reaktif pasca-Streptococcus dan pediatric autoimmune neuropsychiatric disorders associated with Streptococcus pyogenes (PANDAS). Peningkatan kasus infeksi SGA, baik invasif maupun non-invasif, dengan puncaknya di akhir tahun 2022 lalu, khususnya pada populasi anak, telah menjadi perhatian di beberapa negara. Klinisi sangat perlu mengenali berbagai spektrum klinis infeksi SGA, khususnya pada populasi anak.
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Barnham, M. "Streptococcal infection in general practice." Epidemiology and Infection 109, no. 2 (October 1992): 177–80. http://dx.doi.org/10.1017/s0950268800050135.

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The last 30 years have been changes in emphasis in the study of streptococci and streptococcal diseases. Earlier work concentrated mainly on the sources and methods of cross-infection and descriptive epidemiology of Streptococcus pyogenes in its major manifestations of respiratory, cutaneous and invasive infection and in the complications of rheumatic fever (RF), scarlet fever (SF) and post-streptococcal glomerulonephritis (PSGN).
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Masaaki Minami, Shunsuke Akahori, and Michio Ohta. "Amylase from Streptococcus pyogenes inhibits biofilm formation in Streptococcus salivarius." GSC Advanced Research and Reviews 14, no. 2 (February 28, 2023): 047–53. http://dx.doi.org/10.30574/gscarr.2023.14.2.0050.

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Biofilms are extracellular constituents composed of polysaccharides and other substances necessary for bacteria to defend themselves against foreign enemies. Amylase of Streptococcus pyogenes is an enzyme that degrades polysaccharides and other substances and produces nutrients for invasion of epithelial cells. S. salivarius is an oral commensal bacterium that shows antibacterial activity against S. pyogenes. We investigated the relationship between S. pyogenes and S. salivarius to determine whether the amylase of S. pyogenes affects the biofilm of S. salivarius. The amyA gene-deficient strains were generated from S. pyogenes 1529 and MDYK strains, and the amylase production ability of the wild-type and gene-deficient strains were compared. Amylase production in mutant strain was significantly reduced compared to the wild-type strain. Next, the biofilm-forming ability of S. pyogenes was compared between wild-type and mutant strains, and significantly increased biofilm-forming ability was observed in the gene-deficient strains. Next, S. salivarius was cultured to create biofilms, and then wild-type and mutant strains of S. pyogenes were added to the culture. Significantly, the biofilms of S. salivarius with the gene-deficient strains were higher than those with the wild strains. As the biofilm-forming ability of S. salivarius co-cultured with S. pyogenes was compared, the biofilm-forming ability of S. salivarius co-cultured with the mutant strain of S. pyogenes was also significantly increased. These results were common findings for the 1529 and MDYK strains of S. pyogenes. Our results suggest that amylase from S. pyogenes inhibits biofilm formation in S. salivarius.
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Winterhoff, Nora, Ralph Goethe, Petra Gruening, Manfred Rohde, Henryk Kalisz, Hilde E. Smith, and Peter Valentin-Weigand. "Identification and Characterization of Two Temperature-Induced Surface-Associated Proteins of Streptococcus suis with High Homologies to Members of the Arginine Deiminase System of Streptococcus pyogenes." Journal of Bacteriology 184, no. 24 (December 15, 2002): 6768–76. http://dx.doi.org/10.1128/jb.184.24.6768-6776.2002.

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ABSTRACT The present study was performed to identify stress-induced putative virulence proteins of Streptococcus suis. For this, protein expression patterns of streptococci grown at 32, 37, and 42°C were compared by one- and two-dimensional gel electrophoresis. Temperature shifts from 32 and 37 to 42°C induced expression of two cell wall-associated proteins with apparent molecular masses of approximately 47 and 53 kDa. Amino-terminal sequence analysis of the two proteins indicated homologies of the 47-kDa protein with an ornithine carbamoyltransferase (OCT) from Streptococcus pyogenes and of the 53-kDa protein with the streptococcal acid glycoprotein (SAGP) from S. pyogenes, an arginine deiminase (AD) recently proposed as a putative virulence factor. Cloning and sequencing the genes encoding the putative OCT and AD of S. suis, octS and adiS, respectively, revealed that they had 81.2 (octS) and 80.2% (adiS) identity with the respective genes of S. pyogenes. Both genes belong to the AD system, also found in other bacteria. Southern hybridization analysis demonstrated the presence of the adiS gene in all 42 serotype 2 and 9 S. suis strains tested. In 9 of these 42 strains, selected randomly, we confirmed expression of the AdiS protein, homologous to SAGP, by immunoblot analysis using a specific antiserum against the SAGP of S. pyogenes. In all strains AD activity was detected. Furthermore, by immunoelectron microscopy using the anti-S. pyogenes SAGP antiserum we were able to demonstrate that the AdiS protein is expressed on the streptococcal surface in association with the capsular polysaccharides but is not coexpressed with them.
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Noori, Ahmad Zia, Haji Mohammad Naimi, and Hashmatullah Yousufi. "The rate of asymptomatic throat carriage of Streptococcus pyogenes and its associated risk factors among Kabul University students." International Journal of Innovative Research and Scientific Studies 3, no. 4 (December 11, 2020): 142–45. http://dx.doi.org/10.53894/ijirss.v3i4.48.

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Streptococcus pyogenes (S. pyogenes) is the main agent of acute pharyngitis and skin infections that may result in the late complications of glomerulonephritis and rheumatic fever. Infection with streptococcus group A is a global health problem, which is most common in children and adults. This study was conducted to investigate the rate of S. pyogenes throat carriers and its main risk factors among healthy students of Kabul university. In the present study pharyngeal swabs of 260, [155 (59.6%) were male and 105 (40.4%) were female] asymptomatic university students aged between 19-30 years, were collected and immediately transported to the laboratory for detection of S. pyogenes following standard microbiological procedures. Production of beta hemolytic colonies on blood agar, sensitivity to bacitracin antibiotic, gram stain positivity, catalase negativity test and streptococcal grouping latex kit (ProlexTM) tests were used to identify and differentiate S. pyogenes from other streptococcus spp. Statistical analysis of data was performed using SPSS 21, Chi-square and Logistic regression tests were applied for the categorical data analysis. A P value equal to or less than 0.05 was considered statistically significant. Totally 61 (23.5%) beta hemolytic streptococci were isolated from 260 samples. Among 61 beta hemolytic isolates, 44 (16.9%) were identified as S. pyogenes. The colonization rate of S. pyogenes was higher in male 25 (56.8%) than female 19 (43.2%), which was not statistically significant (p=0.678). Age, residence of the students at hostel and shared utensil use were not statistically significant (p=0.088, p= 0.449, p=0.241 respectively), but the number of children in the family was an important risk factor. People with 1-3 children had a 23-fold higher risk (p˂0.05), and people with 4-6 children had a 27-fold higher risk of carrying S. pyogenes, than those who did not had any children (p˂0.05). In the present study the asymptomatic throat carriage rate of S. pyogenes among Kabul University students, was high. Among all risk factors the number of children in the family was significantly associated with S. pyogenes throat carriage.
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Courtney, Harry S., David L. Hasty, and James B. Dale. "Serum Opacity Factor (SOF) of Streptococcus pyogenes Evokes Antibodies That Opsonize Homologous and Heterologous SOF-Positive Serotypes of Group A Streptococci." Infection and Immunity 71, no. 9 (September 2003): 5097–103. http://dx.doi.org/10.1128/iai.71.9.5097-5103.2003.

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ABSTRACT Serum opacity factor (SOF) is a protein expressed by Streptococcus pyogenes that opacifies mammalian serum. SOF is also a virulence factor of S. pyogenes, but it has not been previously shown to elicit a protective immune response. Herein, we report that SOF evokes bactericidal antibodies against S. pyogenes in humans, rabbits, and mice. Rabbit antiserum against purified recombinant SOF2 opsonized SOF-positive M type 2, 4, and 28 S. pyogenes in human blood but had no effect on SOF-negative M type 5 S. pyogenes. Furthermore, affinity-purified human antibodies against SOF2 also opsonized SOF-positive streptococci. A combination of antisera against M2 and SOF2 proteins was dramatically more effective in killing streptococci than either antiserum alone, indicating that antibodies against SOF2 enhance the opsonic efficiency of M protein antibodies. Mice tolerated an intravenous injection of 100 μg of SOF without overt signs of toxicity, and immunization with SOF protected mice against challenge infections with M type 2 S. pyogenes. These data indicate that SOF evokes opsonic antibodies that may protect against infections by SOF-positive serotypes of group A streptococci and suggest that different serotypes of SOF have common epitopes that may be useful vaccine candidates to protect against group A streptococcal infections.
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Dissertations / Theses on the topic "Streptococcus pyogenes"

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Berge, Andreas. "Molecular analysis of Streptococcus pyogenes and its interactions with the human host." Lund : Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/68945123.html.

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Thern, Anette. "Interactions between Streptococcus pyogenes and the human immune system with special reference to C4b-binding protein /." Lund : Dept. of Medical Microbiology, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39224761.html.

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Zhang, Meng. "Proteomic analysis of streptococcus pyogenes." Thesis, Northumbria University, 2007. http://nrl.northumbria.ac.uk/842/.

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Streptococcus pyogenes (group A streptococcus, GAS) is a major human Gram-positive pathogen that causes infections that normally occur in the respiratory tract, the skin, the wound, the lung, the bloodstream and/or muscle tissues and result in millions of deaths every year. To cause such infections, S. pyogenes produces a wide range of virulence factors. The destruction of connective tissue and the hyaluronic acid therein plays an important role in pathogenesis. S. pyogenes was propagated in hyaluronic acid rich growth media in an attempt to create a simple biological system that could reflect some elements of the pathogenesis. The growth of bacteria was analyzed in the hyaluronic acid rich media and control media and a proteomic approach was applied to identify those proteins that were differentially expressed by the streptococcal pathogens growing in the different media. The techniques of two dimensional gel electrophoresis and static nanospray mass spectrometry were optimized and proteome maps for S. pyogenes grown in both media were constructed. The differentially expressed proteins by S. pyogenes were identified and analyzed using bioinformatics. Our results showed that several recognized virulence factors of S. pyogenes were upregulated in hyaluronic acid rich media, including the Ml protein, a collagen-like surface protein and the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase, which has been shown to play important roles in streptococcal pathogenesis. Interestingly, two hypothetical proteins of unknown function were also up-regulated and detailed bioinformatics analysis showed that at least one of these hypothetical proteins is likely to be involved in GAS pathogenesis. It was therefore concluded that this simple biological system provided a valuable tool for the identification of potential streptococcal pathogens virulence factors.
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Siou, Gérard Paul Serge. "Streptococcus pyogenes interactions with human tonsils." Thesis, University of Newcastle upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424082.

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Desai, Meeta. "Molecular epidemiological typing of Streptococcus pyogenes." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299021.

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Broglia, Laura. "Regulating with ribonucleases in Streptococcus pyogenes." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21573.

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Bakterien haben eine Vielzahl an Strategien entwickelt, um sich an ständig wechselnde Umweltbedingungen anzupassen, darunter auch post-transkriptionelle regulatorische Mechanismen. Die Genexpression kann hierbei durch gezielten Abbau oder Stabilisierung von RNA durch Ribonukleasen (RNasen) reguliert werden. RNasen weisen je nach Spezies allerdings unterschiedliche Effekte auf Genexpression und bakterielle Physiologie, sowie verschiedene Strategien der Substraterkennung auf. Dies zeigt, dass unser Verständnis des RNA-Abbaus bei weitem nicht vollständig ist. Ziel dieser Arbeit ist es, die Eigenschaften und Funktionen der endoRNase Y des humanpathogenen Bakteriums Streptococcus pyogenes zu studieren. Um Einblick in Funktion und Spezifität dieser RNase zu gewinnen, wurden deren genomweite Schnittpositionen (“targetome”) mit Hilfe von RNA-Sequenzierung identifiziert. Zur weiteren Analyse des RNase Y-abhängigen RNA-Abbaus wurde dieses Ergebnis mit dem “targetome” der drei 3′-5′-Exoribonukleasen (ExoRNasen) PNPase, YhaM und RNase R verglichen. Schließlich wurden die Anforderungen für die Prozessierung durch RNase Y und deren Rolle in der Regulation von Virulenzgenen in vivo anhand der speB mRNA, die einen wichtigen Virulenzfaktor codiert, untersucht. Wir konnten in dieser Arbeit zeigen, dass RNase Y Substrate bevorzugt nach einem Guanosin schneidet und dieses Nukleosid essenziell für die Prozessierung der speB mRNA in vivo ist. Obwohl RNase Y die speB mRNA schneidet, unterstützen die Daten ein Modell nach dem RNase Y die Expression von speB auf transkriptioneller Ebene reguliert. Mit Hilfe des “targetome”-Vergleichs konnten wir ferner zeigen, dass RNase Y den RNA-Abbau in S. pyogenes initiiert und die dabei generierten 3′-Enden der RNA hauptsächlich von den 3′-5′-exoRNasen PNPase und/oder YhaM prozessiert werden. Zusammenfassend erweitern diese Erkenntnisse unser Verständnis der Funktionalität von RNase Y und des RNA-Abbaus in Gram-positiven Bakterien.
Bacteria have developed a plethora of strategies to cope with constantly changing environmental conditions, including post-transcriptional regulatory mechanisms. With this regard, regulation of gene expression can be achieved by either the rapid removal or stabilization of RNA molecules by ribonucleases (RNases). RNases exhibit species-specific effects on gene expression, bacterial physiology and different strategies of target recognition, indicating that our understanding of the RNA degradation machinery is not yet complete. The aim of this thesis was to investigate the features and functions of endoRNase Y from the strict human pathogen Streptococcus pyogenes. To gain insight into the role and specificity of this RNase, we identified RNase Y cleavage positions (i.e. targetome) genome-wide by RNA sequencing. Next, to investigate the RNA degradation pathway depending on RNase Y, we compared the RNase Y targetome with the ones of the three 3′-to-5′ exoribonuclease (exoRNases), namely PNPase, YhaM and RNase R. Finally, to dissect the requirements for RNase Y processing and to decipher the role of RNase Y in virulence gene regulation, we studied the impact of RNase Y on speB mRNA, encoding a major virulence factor. This study reveals that RNase Y preferentially cleaves RNAs downstream of a guanosine and for the first time we were able to show that the presence of a guanosine residue is essential for the processing of speB mRNA, in vivo. Although RNase Y cleaves the speB mRNA, our data underpin a model in which RNase Y-mediated regulation of speB expression occurs at the transcriptional level. Using the targetome comparative approach, we demonstrated that RNase Y initiates RNA decay in S. pyogenes and that the RNase Y-generated RNA 3′ ends are usually further trimmed by PNPase and/or YhaM. Overall, these findings increase our understanding of RNase Y functionality and RNA degradation in Gram-positive bacteria.
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Becherelli, Marco <1979&gt. "Functional characterization of Streptococcus pyogenes pili." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/3015/1/Becherelli_Marco_Tesi.pdf.

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Group A Streptococcus is a Gram-positive human pathogen able to colonize both upper respiratory tract and skin. GAS is responsible for several acute diseases and autoimmune sequelae that account for half a million deaths worldwide every year (Cunningham et al., 2000). As other bacteria, GAS infections requires the capacity of the pathogen to adhere to host tissues and to form cell aggregates. The ability to persist in distinct host niches like the throat and the skin and to trigger infections is associated with the expression of different GAS virulence factors. GAS pili has been described as important virulence factors encoded by different FCT-operon regions. Based on this information, we decided to study the possible effect of environmental conditions that could regulate the pili expression. In this study we reported the influence of pH environment variations in biofilm formation for strains pertaining to a panel of different GAS FCT-types. The biofilm formation was promoted, excepted in the FCT-1 strains, by a changing in pH from physiological to acidic condition of growth in in vitro biofilm assay. By analyzing the possible association between biofilm formation and pH dependence, we have found that in FCT-2 and FCT-3 strains, the biofilm is promoted by pH reduction leading to an increase of pili expression. These data confirmed a direct link between pH dependent pilus expression and biofilm formation in GAS. As pili are a multi component structure we decided to investigate the functional role of one of its subunits, the AP-1 protein. AP-1 is highly conserved through the different FCT-types and suggests a possible essential role for the pili function. We focused our attention on the AP-1 protein encoded by the FCT-1 strains (M6). In particular this AP-1 protein contains the von Willebrand Factor A (VWFA) domain, which share an homology with the human VWFA domain that has been reported to be involved in adhesion process. We have demonstrated that the AP-1 protein binds to human epithelial cells by its VWFA domain, whereas the biofilm formation is mediated by the N-terminal region of AP-1 protein. Moreover, analyzing the importance of AP-1 in in vivo experiments we found a major capacity of tissue dissemination for the wild-type strain compared to the isogenic AP-1 deletion mutant. Pili have been also reported as potential vaccine candidates against Gram positive bacteria. For these reason we decided to investigate the relationship between cross reaction of sera raised against different GAS and GBS pilin subunits and the presence of a conserved Cna_B domain, in different pilin components. Our idea was to investigate if, using pilus conserved domains, a broad coverage vaccine against streptococcal infection could be possible.
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Becherelli, Marco <1979&gt. "Functional characterization of Streptococcus pyogenes pili." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/3015/.

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Group A Streptococcus is a Gram-positive human pathogen able to colonize both upper respiratory tract and skin. GAS is responsible for several acute diseases and autoimmune sequelae that account for half a million deaths worldwide every year (Cunningham et al., 2000). As other bacteria, GAS infections requires the capacity of the pathogen to adhere to host tissues and to form cell aggregates. The ability to persist in distinct host niches like the throat and the skin and to trigger infections is associated with the expression of different GAS virulence factors. GAS pili has been described as important virulence factors encoded by different FCT-operon regions. Based on this information, we decided to study the possible effect of environmental conditions that could regulate the pili expression. In this study we reported the influence of pH environment variations in biofilm formation for strains pertaining to a panel of different GAS FCT-types. The biofilm formation was promoted, excepted in the FCT-1 strains, by a changing in pH from physiological to acidic condition of growth in in vitro biofilm assay. By analyzing the possible association between biofilm formation and pH dependence, we have found that in FCT-2 and FCT-3 strains, the biofilm is promoted by pH reduction leading to an increase of pili expression. These data confirmed a direct link between pH dependent pilus expression and biofilm formation in GAS. As pili are a multi component structure we decided to investigate the functional role of one of its subunits, the AP-1 protein. AP-1 is highly conserved through the different FCT-types and suggests a possible essential role for the pili function. We focused our attention on the AP-1 protein encoded by the FCT-1 strains (M6). In particular this AP-1 protein contains the von Willebrand Factor A (VWFA) domain, which share an homology with the human VWFA domain that has been reported to be involved in adhesion process. We have demonstrated that the AP-1 protein binds to human epithelial cells by its VWFA domain, whereas the biofilm formation is mediated by the N-terminal region of AP-1 protein. Moreover, analyzing the importance of AP-1 in in vivo experiments we found a major capacity of tissue dissemination for the wild-type strain compared to the isogenic AP-1 deletion mutant. Pili have been also reported as potential vaccine candidates against Gram positive bacteria. For these reason we decided to investigate the relationship between cross reaction of sera raised against different GAS and GBS pilin subunits and the presence of a conserved Cna_B domain, in different pilin components. Our idea was to investigate if, using pilus conserved domains, a broad coverage vaccine against streptococcal infection could be possible.
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McNamara, Case W. "Molecular analysis of Streptococcus pyogenes M1 protein." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3230034.

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Thesis (Ph. D.)--University of California, San Diego, 2006.
Title from first page of PDF file (viewed November 17, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Dixon, Emma Victoria. "Mechanisms of immunoglobulin deactivation by Streptococcus pyogenes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ec80e3f9-0c73-4d39-bc68-c39b927365d4.

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The bacteria Streptococcus pyogenes produces a multitude of proteins which interact with and alter the functions of the host immune system. Two such proteins, Endoglycosidase S (EndoS) and Immunoglobulin G-degrading enzyme from S. pyogenes (IdeS) are able to specifically alter the effector functions of immunoglobulin G (IgG). EndoS is a glycoside hydrolase which removes the conserved N-linked glycan from IgG Fc whereas IdeS is a cysteine protease that cleaves the exible protein hinge of IgG. The activity of both proteins results in the reduced ability of IgG to elicit immune responses through Fc receptor binding and complement activation. Amongst other applications, both EndoS and IdeS are actively being explored as new therapeutics for IgG-mediated autoimmune diseases. Given the therapeutic potential of EndoS and IdeS, experiments were designed to investigate the structural and functional characteristics of these enzymes in an effort to understand their specficity for and activity against IgG. Here, bioinformatic and biophysical characterisation of EndoS identified subdomains outside of the catalytic domain which contribute to glycoside hydrolase activity. The substrate specificity of EndoS was also explored and showed that EndoS hydrolyses a broad range of glycans from the IgG scaffold. EndoS was also shown to have activity against alternative glycoprotein substrates, however, this non-specific activity was negligible in the context of whole serum. The effect of EndoS-mediated deglycosylation on the structure of the IgG Fc domain was explored using both X-ray crystallography and small-angle X-ray scattering. Small angle X-ray scattering was also used to characterise both EndoS and IdeS in complex with IgG Fc. Solution-state models of each complex were produced providing preliminary data towards how these enzymes interact with IgG. Overall, the results presented here contribute to our understanding of these enzymes which is of importance as they go forward into clinical applications.
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Books on the topic "Streptococcus pyogenes"

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Wayne, Charlotte Remy. Roles of Th17 cytokines in microglial and neurovascular responses to recurrent intranasal Streptococcus pyogenes infections. [New York, N.Y.?]: [publisher not identified], 2022.

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R, Johnson Dwight, and World Health Organization, eds. Laboratory diagnosis of group A streptococcal infections. Geneva: World Health Organization, 1996.

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3

Pohl, Barbara. Charakterisierung der Oligopeptidpermease von Streptococcus pyogenes. 1997.

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Vidyasanker, Radhika. The rpsL gene and streptomycin resistance in Streptococcus gordonii and Streptococcus pyogenes. 1999.

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Lydyard, Peter, Michael Cole, John Holton, Will Irving, Nino Porakishvili, Pradhib Venkatesan, and Kate Ward. Case Studies in Infectious Disease: Streptococcus pyogenes. Garland Science, 2009. http://dx.doi.org/10.4324/9780203854082.

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Harrison, Mark. Streptococci and staphylococci. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0013.

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This chapter describes the microbiology of streptococci and staphylococci as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of the methods of spread and clinical features of Streptococcus pneumoniae, Streptococcus pyogenes, alpha-haemolytic streptococci, Staphylococcus aureus, MRSA, and Staphylococcus epidermidis. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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Goroncy-Bermes, Peter. Antikörperkreuzreaktionen zwischen M-Protein von Streptococcus pyogenes und menschlichem Nierengewebe. 1987.

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8

München, Universität, ed. In-vitro-Bakterizidieeffekte simulierter Serum- und Kantharidinblasenflüssigkeitsspiegelprofile bei Staphylococcus aureus- und Streptococcus pyogenes-Hautisolaten. 1987.

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Characterization of a virulence determinant from group A Streptococcus: Identification of a novel chromosomal region responsible for streptolysin S production in Streptococcus pyogenes. Ottawa: National Library of Canada, 1997.

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Kaplan, Edward L., Dwight R. Johnson, Jaroslav Sramek, Ruth Bicova, Jiri Havlicek, Helena Havlickova, Jitka Motlova, and Paula Kriz. Laboratory Diagnosis of Group a Streptococcal Infections(1150441). World Health Organization, 1997.

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Book chapters on the topic "Streptococcus pyogenes"

1

Stechenberg, Barbara. "Streptococcus pyogenes." In The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes, 209–13. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-391-2_15.

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Lydyard, Peter M., Michael F. Cole, John Holton, William L. Irving, Nina Porakishvili, Pradhib Venkatesan, and Katherine N. Ward. "Streptococcus pyogenes." In Case Studies in Infectious Disease, 329–38. 2nd ed. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003155447-35.

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Breathnach, Aodhán S., and Susannah J. Eykyn. "Streptococcus pyogenes Bacteraemia." In Streptococci and the Host, 57–58. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1825-3_14.

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Reichardt, W. "Streptococcus pyogenes." In Contributions to Microbiology, 90–101. Basel: KARGER, 2001. http://dx.doi.org/10.1159/000060404.

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Wagner, Barbara, Dieter Gerlach, Jörg-Hermann Ozegowski, and Manfred Wagner. "Superantigens of Group A Streptococci (Streptococcus pyogenes)." In Streptococci and the Host, 555–57. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1825-3_128.

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Erdem, Guliz, and Edward L. Kaplan. "Rheumatic Complications of Streptococcus pyogenes." In The Microbiome in Rheumatic Diseases and Infection, 97–102. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-79026-8_9.

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McShan, W. Michael, Kimberly A. McCullor, and Scott V. Nguyen. "The Bacteriophages of Streptococcus pyogenes." In Gram-Positive Pathogens, 158–76. Washington, DC, USA: ASM Press, 2019. http://dx.doi.org/10.1128/9781683670131.ch11.

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Stevens, D. L. "Virulence Factors of Streptococcus pyogenes." In Streptococcal Pharyngitis, 3–15. Basel: KARGER, 2003. http://dx.doi.org/10.1159/000076206.

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Cornaglia, G., and A. Bryskier. "Macrolide Resistance of Streptococcus pyogenes." In Streptococcal Pharyngitis, 150–65. Basel: KARGER, 2003. http://dx.doi.org/10.1159/000076224.

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Ferretti, Joseph J., Bruce A. Roe, Sandy W. Clifton, Shao Ping Lin, Xiling Wang, Min Zhan, Adonis Reece, Alexander N. Suvorov, and W. Michael McShan. "The Streptococcus pyogenes Genome Sequencing Project." In Streptococci and the Host, 961–63. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1825-3_226.

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Conference papers on the topic "Streptococcus pyogenes"

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López, Laura, Cristina Gutiérrez, Laura Morales, María de Felipe, Antonio Jesús Morales, María del Pilar Uribe, Laura Escobar, and José Manuel Marugán. "INFECCIONES INVASIVAS POR STREPTOCOCCUS PYOGENES: ALERTA MUNDIAL." In 37 Congreso Nacional de la Sociedad Española de Pediatría y Atención Primaria - SEPEAP 2023. Grupo Pacífico, 2023. http://dx.doi.org/10.48158/sepeap2023.o020.

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Ozalinskaite, A., C. Kladt, M. Popovic, N. Sipulina, D. Djordjevic, M. Ahmed, S. Schäfer-Rösch, and C. Mundhenke. "Postpartales toxisches Schocksyndrom, verursacht durch Streptococcus pyogenes." In 64. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e. V. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1756982.

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LAMBERTON, G. R., M. J. PEREAU, K. ILLES, I. L. KELLY, J. CHRISLER, B. J. CHILDERS, K. C. OBERG, and A. A. SZALAY. "CONSTRUCTION AND CHARACTERIZATION OF A BIOLUMENESCENT STREPTOCOCCUS PYOGENES." In Bioluminescence and Chemiluminescence - Progress and Current Applications - 12th International Symposium on Bioluminescence (BL) and Chemiluminescence (CL). WORLD SCIENTIFIC, 2002. http://dx.doi.org/10.1142/9789812776624_0018.

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Konstantinova, S. V., I. S. Boksha, V. G. Lunin, T. A. Danilova, M. S. Poponova, A. M. Lyashchuk, Z. M. Galushkina, and E. V. Ustenko. "LYTIC ENZYMES OF STREPTOCOCCI: POSSIBILITIES OF USING." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-90.

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Pathogenic streptococci synthesize enzymes that cleave human IgG: Streptococcus pyogenes synthesizes IdeS, and S. zooepidemicus — IdeZ. We have produced recombinant IdeS and IdeZ, the properties and activity of which are identical to those of the enzymes described in literature. The specificity of IgG cleavage with recombinant IdeS and IdeZ has been confirmed by mass spectrometry. The possibility of using recombinant IdeS and IdeZ in medicine, veterinary medicine and biotechnology has been shown
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Tek, Erhan, and Nizami Duran. "Efficacy of Capsaicin on Cell Adhesion and Invasion of Oral Pathogens." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.iii.19.

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Streptococcus pyogenes, Streptococcus mutans, and Candida albicans are important human pathogens and their infections in the mouth, mouth, and throat are important. Prophylaxis against oral and respiratory tract infections is of great importance in terms of both reducing the use of antibiotics and lowering the infection frequency. This study investigated the antimicrobial activity of Capsaicin against S. mutans, C. albicans, and S. pyogenes. Non-cytotoxic concentration of Capsaicin was determined in the Vero cell line by the MTT method. Efficacy studies were performed within these determined non-cytotoxic concentrations. The efficacy of single and different combinations of these three biological components on cell adhesion and invasion. The non-toxic concentration of capsaicin on Vero cells was <1.35 µg/ml. Capsaicin exhibited significant antimicrobial activity against S. pyogenes, S. mutans, and C. albicans. Moreover, capsaicin was statistically significantly effective against host cell adhesion and invasion against S. mutans, S. pyogenes and C. albicans compared to the control group. The results showed that capsaicin is a highly potent antibacterial agent against S. pyogenes, and S. mutans, as well as an important prophylactic agent for fungal infections. As a result, we think that capsaicin is a useful molecule for the provision and maintenance of both respiratory diseases and oral health.
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Santos, Laura, Clara Simón, Vanessa Moya, Mara Rodríguez, Esther Mesa, María Álvarez, Oihane Salcedo, Sara Rodríguez, Aroa Alonso, and Diana Katherine Segura. "ESPECTRO DE PRESENTACIÓN DE STREPTOCOCCUS PYOGENES Y DIAGNÓSTICO DIFERENCIAL." In 37 Congreso Nacional de la Sociedad Española de Pediatría y Atención Primaria - SEPEAP 2023. Grupo Pacífico, 2023. http://dx.doi.org/10.48158/sepeap2023.p074.

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Soares, Andréia Guímel de Sousa, Ana Beatriz Moura e. Silva, Ana Léia Esteves Cruz, Camily Vitória Lima Da Silva, and Lícia de Sousa Gonçalves. "PERFIL DE RESISTÊNCIA DE STREPTOCOCCUS PYOGENES EM CRIANÇAS NO BRASIL: UMA REVISÃO BIBLIOGRÁFICA." In IV Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2024. http://dx.doi.org/10.51161/conamic2024/30382.

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VILLALONGA, LEIRE, MIREN IRATI PÉREZ, MAREN EIZAGUIRRE, PATRICIA DE MIGUEL, Mª CONCEPCIÓN LLANOS, JUAN CARRASCOSA, EDURNE AMORENA, ANDREA GOIKOETXEA, CORO MIRANDA, and JUAN JOSÉ VILA. "Gastritis flemonosa por Streptococcus Pyogenes: Diagnóstico endoscópico de esta rara entidad con elevada morbimortalidad." In 45 Congreso Nacional de la Sociedad Española de Endoscopia Digestiva. Grupo Pacífico, 2023. http://dx.doi.org/10.48158/seed2023.p272.

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Hermann, A., J. M. Beiersdorf, B. Vogt, S. Schrey-Petersen, and H. Stepan. "Maternale Sepsis durch Streptococcus pyogenes in der 33+2. SSW bei bekanntem Morbus Crohn." In Kongressabstracts zur 16. Jahrestagung der Mitteldeutschen Gesellschaft für Frauenheilkunde und Geburtshilfe e.V. (MGFG). Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1769827.

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Hofmann, K. M., M. Brauer, A. Kortgen, and M. Bauer. "Fibrinolysis resistance in a patient with Streptococcus pyogenes associated septic shock and necrotizing fasciitis." In GTH Congress 2024 – 68th Annual Meeting of the Society of Thrombosis and Haemostasis Research – Building Bridges in Coagulation. Georg Thieme Verlag, 2024. http://dx.doi.org/10.1055/s-0044-1779204.

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Reports on the topic "Streptococcus pyogenes"

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de Infectología, Comité Nacional. Alerta sobre infecciones graves por Streptococcus pyogenes en niños. Buenos Aires: siicsalud.com, September 2018. http://dx.doi.org/10.21840/siic/158683.

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Gergova, Raina, Adile Muhtarova, Gergana Petrova, Stefan Gergov, Milka Dikova, and Ivan Mitov. Comparison of Cultural, Immunological and New PCR Techniques for Detection of Streptococcus pyogenes. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, October 2018. http://dx.doi.org/10.7546/crabs.2018.10.16.

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Gergova, Raina, Adile Muhtarova, Lyudmila Boyanova, and Rumyana Markovska. Distribution of msr(D), mef(A/E), emm Genotypes and Virulence Profiles among Bulgarian Macrolide Resistant Streptococcus pyogenes Isolates. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, November 2021. http://dx.doi.org/10.7546/crabs.2021.11.13.

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