Dissertations / Theses: 'Strategic candidates'

1

Brown, Adam Robert. "Strategic politicians in gubernatorial elections." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3311418.

Full text

Abstract:

Thesis (Ph. D.)--University of California, San Diego, 2008.
Title from first page of PDF file (viewed Aug. 1, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 130-137).

APA, Harvard, Vancouver, ISO, and other styles

2

Manzoni, Elena. "Electoral campaigns with strategic candidates : a theoretical and empirical analysis." Thesis, London School of Economics and Political Science (University of London), 2010. http://etheses.lse.ac.uk/2388/.

Full text

Abstract:

The main focus of this thesis is the analysis of political campaigns when candidates choose their statements in a strategic way. In the first chapter, 'Discretion and renegotiation in electoral campaigns', I present a model of electoral campaigning as a problem of competitive delegation. The chapter considers a situation in which there is uncertainty about what the optimal policy should be; in this environment voters may want to leave discretion to a candidate, in order to allow him to adjust his policies to the state of the world, once he is elected. The paper analyses how the ambiguity level of the political statements is influenced by the presence of uncertainty over the candidates' ideology, by the possibility of ex post renegotiation between the elected candidate and the voters and by several political variables. In the second chapter, 'Last minute policies and the incumbency advantage', joint with Stefan Penczynski, we investigate the timing of statements in political debates and campaigns. Early statements can influence the political agenda and signal competence and vision, late statements are based on more information about appropriate measures. We find that candidates speak early on issues they are better-informed about in order to signal relevance and move them up the agenda. Since opponents benefit from this revelation, however, candidates remain silent once their information is sufficiently precise and valuable. In the last chapter, 'Discretion and ambiguity in electoral campaigns: a look into the empirical evidence', I compare several models of ambiguity in electoral campaigns, including my own model which was introduced in the first chapter. I use the methodology of Campbell (1983) to have a proxy for ambiguity of the electoral statements, and the data from the American National Election Studies on Senate elections from 1988-1990-1992, to investigate which of the correlations predicted by these models seem to be present in the data.

APA, Harvard, Vancouver, ISO, and other styles

3

MANZONI, ELENA. "Electoral campaigns with strategic candidates: a theoretical and empirical analysis." Doctoral thesis, London School of Economics, 2010. http://hdl.handle.net/10281/67212.

Full text

Abstract:

The main focus of this thesis is the analysis of political campaigns when candidates choose their statements in a strategic way. In the first chapter, ‘Discretion and renegotiation in electoral campaigns’, I present a model of electoral campaigning as a problem of competitive delegation. The chapter considers a situation in which there is uncertainty about what the optimal policy should be; in this environment voters may want to leave discretion to a candidate, in order to allow him to adjust his policies to the state of the world, once he is elected. The paper analyses how the ambiguity level of the political statements is influenced by the presence of uncertainty over the candidates’ ideology, by the possibility of ex post renegotiation between the elected candidate and the voters and by several political variables. In the second chapter, ‘Last minute policies and the incumbency advantage’, joint with Stefan Penczynski, we investigate the timing of statements in political debates and campaigns. Early statements can influence the political agenda and signal competence and vision, late statements are based on more information about appropriate measures. We find that candidates speak early on issues they are better-informed about in order to signal relevance and move them up the agenda. Since opponents benefit from this revelation, however, candidates remain silent once their information is sufficiently precise and valuable. In the last chapter, ‘Discretion and ambiguity in electoral campaigns: a look into the empirical evidence’, I compare several models of ambiguity in electoral campaigns, including my own model which was introduced in the first chapter. I use the methodology of Campbell (1983) to have a proxy for ambiguity of the electoral statements, and the data from the American National Election Studies on Senate elections from 1988-1990-1992, to investigate which of the correlations predicted by these models seem to be present in the data.

APA, Harvard, Vancouver, ISO, and other styles

4

Cho, Sungdai. "Third party candidates and sophisticated voters : spatial competition and strategic voting in multicandiate American presidential elections /." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9962511.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Lazarus, Jeffrey. "Strategic entry in US House elections : assessing the causes and effects of interaction among incumbents and challengers /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3144331.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Arvidsson, Viktor. "A model for strategic e-service implementation in the public sector : challenges for local governments in identifying potential candidates for e-service delivery." Thesis, Umeå University, Department of Informatics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34875.

Full text

Abstract:

As more and more local governments begin to understand that the great promises of e-service delivery are harder than expected to realize, efficient use of ICT-resources have become increasingly important. Since simply providing more e-services is not the solution, the need to understand what constitutes a suitable e-service has arisen. Public services reach beyond the market domain; therefore, the complexities of public value must be dealt with when services are appraised. Furthermore, due to the heterogeneous nature of local government services it is impossible to evaluate all the options in depth; thus, there is a clear need for early-stage appraisal. However, existing methods of appraisal are burdened by intricacy, and associated with high costs. In response, this paper presents a model capable of reducing this intricacy. The model was developed through a participatory design process involving members on both operational and strategic level in the municipality of Skellefteå. The model implements state of the art into the workspace context while taking measures to reduce intricacy such as: incremental filtering, moving high intricacy elements to the end of the process, and exploitation of available data. As a result the organization is enabled to capture not only the low hanging fruit, but also the long tail of services. Furthermore, the improved understanding of e-service delivery has the potential to open up opportunities for new ways of business development and private-public partnerships. Finally, whereas the model presented is highly context-dependent, the implications outlined in this paper are not limited to this narrow scope.

Models for Strategic Business Development in Public Service

APA, Harvard, Vancouver, ISO, and other styles

7

Silotto, Graziele Cristina. "A dimensão regional das estratégias partidárias em eleições proporcionais de lista aberta no Brasil." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/8/8131/tde-10032017-135505/.

Full text

Abstract:

Este trabalho aborda a questão regional enquanto uma estratégia dos partidos na arena eleitoral. Ao acrescentar a dimensão partidária aos trabalhos que advogam pela regionalização dos distritos eleitorais de elevada magnitude, o intuito foi mostrar que é do sistema eleitoral, sobretudo da lista aberta, da magnitude e da estrutura da competição que emanam os incentivos à subdistritalização. Como uma perspectiva teórica alternativa à solução distributivista, o argumento é que o sistema eleitoral traz o elemento regional ao plano das decisões partidárias, isto é, a subdistritalização ocorreria em decorrência da ação intencional política que, com isso, garantiria a diminuição ou a ausência da competição intrapartidária no território. O resultado da análise da lista de candidatos brasileira reforça que o meio social e o político respondem aos fatores regionais, que influencia suas atitudes e estratégias. Por meio de uma dinâmica não política, mas geoespacial partidos encontram estratégias para lidar com as restrições institucionais a fim de atingir o sucesso eleitoral.
This thesis considers the regional question as a partisan strategy in the electoral arena. The goal is to show that from the electoral system, especially the open list proportional representation, the magnitude and the structure of the electoral competition, emanates the incentives for subdistricting. Therefore, partisanship is introduced, adding a new dimension to the scholarship that advocates for the regionalization of the high magnitude districts. When arguing that, in fact, parties decisions are influenced by regional elements which were fostered by the electoral system, this study pursues an alternative theoretical perspective to distributivism. Subdistricting is a byproduct of intentional political action, which, in turn, ensures the decrease or absence of intra-party competition over the territory. The findings based on the analysis of the list of candidates presented by parties in Brazil reinforces that the social and political environment responds to regional factors that influence their attitudes and strategies. Through a non-political, but geospatial dynamic, parties can strategically deal with the institutional constraints in order to achieve electoral success.

APA, Harvard, Vancouver, ISO, and other styles

8

Rock, Terryl. "Strategies to Support Secondary Ed and MAT Candidates." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/3263.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Rodríguez, Álvarez Carmelo. "Strategic incentives in multivalued social choice processes." Doctoral thesis, Universitat Autònoma de Barcelona, 2002. http://hdl.handle.net/10803/4031.

Full text

Abstract:

Cuando los miembros de una sociedad tienen que tomar una decisión sobre un conjunto de alternativas suelen usar ciertas reglas que tratan de alcanzar un acuerdo entre sus diferentes intereses. Estas reglas se suelen denominar mecanismos de votación, procedimientos de elección social o, simplemente, elecciones. Las reglas de votación definen escenarios en los que los miembros de la sociedad interaccionan y tratan de obtener el mejor resultado de acuerdo con sus preferencias. Esta tesis doctoral está dedicada al estudio de los incentivos estratégicos de los participantes (votantes y candidatos) en procesos de elección social.
Nuestro análisis se centra en modelos generales en los que se admite que el resultado de la elección consista en un conjunto de alternativas. Aunque resulta natural suponer que sólo una alternativa será finalmente elegida, existen múltiples situaciones en las que este supuesto es sumamente restrictivo. Por ejemplo, podríamos considerar la elección como una etapa intermedia en el proceso de decisión. El objeto del proceso electoral sería reducir el número de alternativas entre las que la sociedad tendría que escoger. Con esta interpretación, nos centraríamos en situaciones en los que existe cierto grado de incertidumbre sobre la resolución final de la elección social.
En esta tesis seguimos dos importantes ramas de la literatura de la teoría de la elección social, el estudio de reglas decisión social no manipulables y el análisis de los problemas de candidatura estratégica.
En primer lugar, siguiendo el trabajo seminal de Dutta, Jackson y Le Breton (Econometrica, 2001) estudiamos los incentivos de los candidatos para entrar o abandonar la lucha electoral con la intención de afectar al resultado de la elección. Si los candidatos comparan conjuntos de candidatos de forma consistente con los postulados de la teoría de la utilidad esperada, cualquier regla de decisión unánime y no dictatorial provee a algún candidato con incentivos a abandonar su candidatura. Sin embargo, si los candidatos comparan los resultados de la elección de acuerdo con métodos menos sofisticados, sí que se pueden obtener resultados positivos.
Seguidamente, pasamos a analizar los incentivos estratégicos de los candidatos en un entorno complementario: en el que el resultado de la elección es explícitamente probabilístico. En esta situación podemos caracterizar la familia de reglas de votación que nunca incentivan la salida de ningún candidato. Sorprendentemente, aunque la familia de dictadores aleatorios juega un papel central dentro de la caracterización, podemos probar que reglas de decisión más flexibles también satisfacen los requerimientos de estabilidad en las candidaturas.
Finalmente, nos centramos en la posibilidad de construir reglas de decisión no manipulables cuando los votantes comparan conjuntos de alternativas de acuerdo con actitudes extremas ante el riesgo. En este contexto, analizamos la compatibilidad entre la condición de no manipulabilidad y otras condiciones de regularidad que han sido propuestas en la literatura como por ejemplo, Resolución Residual. Además, también presentamos los requerimientos en las preferencias de los votantes sobre conjuntos de alternativas que reducen la posibilidad de reglas de decisión no manipulables a reglas dictatoriales.
When a society has to make a choice from an array of alternatives, it usually relies on certain rules that try to reconcile the opposite interest of the members of the society. These rules define environments in which the agents interact and try to obtain the best outcome according to their preferences. This work is devoted to the study of the strategic incentives of the participants in the social decision processes.
We analyse general frameworks in which the outcome of the social choice process can be multivalued. Even when it seems natural to assume that the result of an election as a singleton, there are many situation in which our assumption should not be precluded. For instance, we can consider the social decision process as an interim stage that narrows the social agenda. Another possibility is to consider the set of the possible equilibria that could eventually arise in the voting procedure as the outcome of the election.
Our study focuses on two important branches of the literature, the study of strategy-proof social choice correspondences and the analysis of strategic candidacy in multivalued voting procedures.
First, we study the possibility of constructing non-manipulable social choice correspondences when the voters have strict attitudes towards risk. We analyse the trade-off between strategy-proofness and some regularity conditions proposed in the literature like Residual Resoluteness. Moreover, we introduce necessary conditions for strategy-proof and onto social choice correspondences. We also present the requirements in voters' preferences over sets of alternatives that reduce the possibility of strategy-proof correspondences to dictatorial ones.
Second, we study the incentives of candidates to enter or to exit elections in order to affect strategically the outcome of a voting correspondence. We show that, if candidates form their preferences over sets according to Expected Utility Theory and Bayesian Updating, every unanimous and non dictatorial voting correspondence violates candidate stability, at least a candidate has incentives to leave the ballot at one profile of preferences. We also analyse the implications of using other extension criteria to define candidate stability that open the door to positive results.
Finally, we analyse the strategic incentives of the candidates to withdraw the election in probabilistic environments. We characterise the family of unanimous and candidate stable probabilistic voting procedures when the candidates are expected utility maximisers. Surprisingly, we show that there are rules that are not probabilistic combinations of single-valued candidate stable voting procedures (random dictatorships) that do not provide incentives to the candidates to withdraw the election.

APA, Harvard, Vancouver, ISO, and other styles

10

Wilson, Justin Jeff. "Synthetic strategies for the design of platinum anticancer drug candidates." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82326.

Full text

Abstract:

Thesis (Ph. D. in Inorganic Chemistry)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.
Cataloged from PDF version of thesis. Vita.
Includes bibliographical references.
Chapter 1. The Synthetic Chemistry of Platinum Anticancer Agents Since the inception of cisplatin as a clinically approved anticancer agent, a large number of platinum compounds have been synthesized with the aim of finding new, improved drugs. As a result of these efforts, only two additional platinum-based drugs received FDA approval for the treatment of cancer. Nevertheless, fundamental advancements in the synthetic chemistry of platinum arose from these research endeavors. This chapter presents a comprehensive review of synthetic methods for the preparation of classic and non-conventional platinum compounds with therapeutic potential. Chapter 2. Platinum(II) Complexes Bearing Fluorescent Di-2-Pyridylmethane Ligands A strategy to investigate the cellular uptake and localization of platinum anticancer agents is to label them with a fluorescent ligand. In pursuit of this strategy, three new platinum(II) complexes with modified di-2-pyridylmethane (dpm) ligands, two of which are fluorescent, were prepared. These new ligands contain either a non-fluorescent tosyl group (Ts-dpm) or fluorescent NBD or dansyl group (NBD-dpm and dansyl-dpm). The photophysical and solution conformational properties of the complexes [Pt(dpm')C12], where dpm' is one of the three ligands described above, are presented. The thermal and photolytic decomposition products and the hydrogen peroxide oxidation products were investigated. Chapter 3. Outer-Sphere Amide Bond Coupling Reactions for the Preparation of a Fluorescent Platinum(IV) Redox Sensor Because of the poor solubility, stability, and lack of structural similarity to clinically used platinum anticancer agents of the complexes described in Chapter 2, synthetic strategies were devised to prepare alternative fluorescent platinum compounds. The dangling carboxylic acid groups of the platinum(II) complexes [Pt(edma)C 2] and [Pt(edda)C12], where edma = ethylenediamine-N-acetic acid and edda = ethylenediamine-N,N'-diacetic acid, were functionalized by amide bond coupling using benzyl amine. For [Pt(edda)C12], the resulting product was a mixture of diastereomers owing to chirality at both coordinating nitrogen atoms. Only [Pt(edma)C12] was further modified by coupling it to dansyl ethylenediamine to form [Pt(edDS)C12], where edDs is the dansyl ethylenediamine-containing ligand. Upon oxidation of this complex with iodobenzene dichloride, the emission of the dansyl fluorophore was substantially quenched. By reducing the oxidized product [Pt(edDs)C14] with an excess of the biological reducing agents glutathione, cysteine, and ascorbic acid in aqueous buffer, a 6.3-fold turn-on in emission intensity was observed. This turn-on response suggests that [Pt(edDs)C14] and its anologues may serve as fluorescent redox sensors to monitor the reduction of platinum(IV) in living cells. Chapter 4. In Vitro Anticancer Activity of Platinum(II) Complexes with p-Diketonate Leaving Group Ligands To investigate the role of the leaving group ligand on the anticancer activity of platinum(II) complexes, five compounds with the general formula [Pt(NH3)2([beta]-diketonate)]+ were prepared and characterized. The [beta]-diketonate ligands were chosen to tune the lipophilicity and electrophilicity of the resulting complexes. Three general synthetic protocols for preparing such complexes were established. These compounds were tested for anticancer activity in a panel of four different cell lines. Structure-activity relationships were derived, correlating high cytotoxicity with increasing lipophilicity and decreasing donor strength of the p-diketonate. Chapter 5. Acetate-Bridged Dinuclear Platinum(III) Complexes Derived from Cisplatin The oxidation chemistry of a previously reported acetate-bridged dinuclear cisdiammineplatinum( II) complex, cis-[Pt"(NH 3)2(p-OAc) 2Pt"(NH 3)2](NO 3)2, was explored. Treatment of this complex with either PhICl2 or Br2 afforded the 2-electron oxidized halidecapped dinuclear complexes, cis-[XPt"I(NH 3)2([beta]-OAc) 2Ptl"(NH3)2X](NO3)2, where X is either bromine or chlorine. The platinum(II) and platinum(III) complexes were fully characterized by X-ray crystallography and multinuclear NMR spectroscopy. The oxidation of cis-[Ptr(NH3)2([mu]t-OAc)2PtIII(NH3)([mu]-NH2)]2(NO3)2 with PhI(O2CCF3)2 and XeF2 was also explored. The use of PhI(O2CCF3)2 gave the unexpected amido-bridged tetranuclear platinum(III) complex, cis-[(O2CCF3)PtIII(NH3)2([mu](pi-OAc)2PtIII(NH3)([mu]-NH2)]2(NO3)4, which was characterized structurally by X-ray crystallography. From the analogous reaction using XeF2 instead of PhI(O 2CCF3 )2 , yellow crystals were obtained, and the crystal structure revealed an infinite chain of acetatebridged dinuclear platinum units.
(cont'd) Chapter 6. Synthesis, Characterization, and Cytotoxicity of Platinum(IV) Dicarbamate Complexes The reaction of cis,cis,trans-[Pt(NH3)2Cl2(OH)2] with alkyl and aryl isocyanates (RNCO) in DMF afforded dicarbamate complexes of the general formula cis,cis,trans- [Pt(NH 3)2Cl 2(O 2CNHR)2]. The resulting complexes were fully characterized by X-ray crystallography, multinuclear NMR spectroscopy, and cyclic voltammetry. The anticancer activities of these complexes were assessed in human lung cancer (A549) and human lung fibroblast (MRC-5) cell lines. Although no clear structure-activity relationships could be delineated, the complexes exhibited activity on the same order of magnitude as that of the clinically established drug cisplatin. Therefore, the reaction of cis,cis,trans-[Pt(NH3)2Cl 2(OH)2] with isocyanates provides a powerful new synthetic pathway to functionalize platinum(IV) anticancer agents. Appendix A. Aqueous Electrochemistry of a Platinum(IV) Prodrug Electrochemical studies of cis,cis,trans-[Pt(NH3)2Cl2(OAc) 2] in aqueous media were carried out. Cyclic voltammetry in pH 7.4 phosphate-buffered saline with glassy carbon and Pt disk working electrodes gave substantially different peak potentials for the irreversible reduction feature. Under these conditions, the glassy carbon electrode was plated with platinum metal derived from the platinum(IV) complex, as determined by cyclic voltammetry and chronoamperometry experiments. The bulk electrolysis of cis,cis,trans-[Pt(NH3)2Cl2(OAc)2] in aqueous solution at a carbon felt working electrode was investigated by 1H NMR spectroscopy. These studies indicate ligand loss upon reduction from both axial and equatorial sites of the platinum(IV) complex. Appendix B. Targeting the Mitochondria with Platinum Anticancer Agents using Mitochondria-Penetrating Peptides Early results of a collaborative effort with the lab of Professor Shana 0. Kelley at the University of Toronto to deliver platinum anticancer agents to the mitochondria are presented. Succinylacetone (Hsuccac) was used as a leaving group ligand for a cis-diammineplatinum(II) complex. The complex [Pt(succac)(NH 3)2](NO3), which contains a terminal, uncoordinated carboxylic acid functional group, was prepared and fully characterized. This complex was conjugated to a mitochondria-penetrating peptide (MPP) using standard solid-phase coupling chemistry. The anticancer activity of the Pt-MPP construct was tested in both wild-type and cisplatin-resistant ovarian cancer cell lines, A2780 and A2780CP70. Although less potent than cisplatin, the construct is equally toxic to both cell lines, thereby indicating that targeting the mitochondria provides a viable strategy for circumventing resistance to platinum drugs. Appendix C. Synthesis and Characterization of Several Novel Platinum Complexes Throughout the course of this thesis work, several platinum complexes were synthesized and characterized, but ultimately not fully pursued as potential anticancer agents. These species include platinum compounds with dichloroacetate, 2,2'-bis(1- methylimidazolyl)phenylmethoxymethane (BIPhMe), nitrogen mustard-containing, and nitroimidazole-derivatized ligands. The syntheses and characterization of these compounds are reported. Crystal structures are described for several of them.
by Justin Jeff Wilson.
Ph.D.in Inorganic Chemistry

APA, Harvard, Vancouver, ISO, and other styles

11

Rohrbough, James Gary Jr. "Identification of Protein Vaccine Candidates Using Comprehensive Proteomic Analysis Strategies." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194491.

Full text

Abstract:

Presented in this dissertation are proteomic analysis studies focused on identifying proteins to be used as vaccine candidates against Coccidioidomycosis, a potentially fatal human pulmonary disease caused by inhalation of a spore from the soil-dwelling pathogenic fungi Coccidioides posadasii and C. immitis. A method of tandem mass spectrometry data analysis using dual protein sequence search algorithms for increasing the total protein identifications from an analysis is described. This method was utilized in a comprehensive proteomic analysis of cell walls isolated from the dimorphic fungal pathogen C. posadasii. A strategy of tandem mass spectrometry-based protein identification coupled with bioinformatic sequence analysis was used to produce a list of protein vaccine candidates for further testing. A differential proteome analysis using stable isotope protein labeling was undertaken to identify vaccine candidate proteins that are more highly expressed in the spherule, or pathogenic phase, of C. posadasii. The results of these analyses are 9 previously undescribed protein vaccine candidates isolated from spherule cell walls that have sequence indications of extracellular association such as GPI anchors and N-terminal signal sequences and antigen potential based on homology to known antigenic or secreted proteins. An additional 14 proteins identified from spherule cell walls are potential vaccine candidates based on extracellular sequence predictions without any indications of antigenic potential. The stable isotope labeling study has identified 3 more proteins that are preferentially expressed in spherules and exhibit antigenic potential based on extracellular localization or homology to known antigenic proteins. Additionally, there were 5 unknown function proteins identified by stable isotope labeling that are more highly expressed in spherules that may be good vaccine candidates but cannot be identified or localized by sequence analysis.The dual algorithm protein identification method presented here is a new technique to address some common shortcomings associated with a proteomic analysis. The comprehensive proteomic analyses of Coccidioides posadasii presented here have provided new targets for Coccidioidomycosis vaccine development as well as insights into the proteome of this pathogen, such as the sequence comparison of C.posadasii proteins to human proteins, as well as a comprehensive analysis of predicted protein function in the Coccidioides proteome.

APA, Harvard, Vancouver, ISO, and other styles

12

Hogan, Norma, and Terryl Rock. "edTPA: Strategies and Supports for Teacher Candidates in Secondary Education." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/3262.

Full text

Abstract:

First, Norma Hogan and Terryl Rock will briefly review the challenges of working with teacher candidates in secondary education. Then, we will discuss the strategies and supports we have developed to meet our teacher candidate’s needs, provide examples of strategies and supports we have found effective with this group, and involve participants in sharing their ideas and lessons learned. A few examples of strategies include offering special workshops on lesson planning, developing assignments that mirror edTPA tasks, and changing our academic language to match edTPA terminology. A few examples of supports include a revised lesson plan template and providing models, sentence frames, and annotations for edTPA responses. We will also involve participants through questioning and small group discussion in sharing their experiences and what has/has not worked.

APA, Harvard, Vancouver, ISO, and other styles

13

Pont, Masanet Caterina. "Multitarget strategies in search of novel drug candidates against Alzheimer’s disease." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/668672.

Full text

Abstract:

Alzheimer’s disease (AD) is the most common form of dementia and one of the most important health-care problems in the world, due to its high prevalence and unaffordable personal and economic impact. Moreover, current commercialised treatments are only symptomatic, but are not capable of preventing, curing or even delaying the disease progression. Because AD arises from a complex network of pathological events, such as dysfunction in neurotransmitter systems (mainly cholinergic and glutamatergic), β-amyloid and tau proteins disorders, oxidative stress or neuroinflammation, amongst others, the traditional medicinal chemistry paradigm of “one molecule-one target” is increasingly regarded as clearly ineffective. On the contrary, it becomes evident that a more comprehensive, complex pharmacological approach is needed to tackle AD. As a consequence, the use of multitarget directed ligands, where one single molecule is able to interact simultaneously with multiple targets of the pathological network, is emerging as a promising and more realistic way to confront this disease. In this context, the purpose of the present Thesis was the design, synthesis and biological evaluation of three novel families of compounds, endowed with multitarget biological profile, in order to find novel treatments for AD: 1) firstly, a new series of compounds designed by substitution of the rhein subunit of a rhein–huprine hybrid lead, previously developed in our group, by more simplified scaffolds, with the aim of finding optimized hybrids with reduced lipophilicity and better drug-like properties, while maintaining favourable activities against cholinesterases, BACE1, β- amyloid and tau aggregation, and antioxidant properties; 2) secondly, a novel family of huprine- derived hybrids, designed to perform a dual binding site interaction within BACE1 through the linkage of a huprine moiety to new scaffolds, selected by their predicted binding affinities towards a secondary transient pocket in BACE1, which were expected to combine cholinesterases and BACE1 inhibitory activities, as well as activity against β-amyloid and tau aggregation, and antioxidant properties; 3) finally, a family of huprine–TPPU and tacrine–TPPU hybrids, which were designed to be dual inhibitors of acetylcholinesterase (AChE) and soluble epoxide hydrolase (sEH). The blood–brain barrier permeability was also assessed for all these compounds, as it is a crucial factor for drugs acting in the central nervous system, while other important physicochemical and pharmacokinetic parameters, such as solubility and microsomal stability were determined for the latter series of compounds. Also, the toxicity of some compounds was evaluated. Finally, using the same assay that was employed for the determination of the β-amyloid and tau antiaggregating activity of the first two families and other compounds synthesised by our group, we demonstrated that a single compound can be able of inhibiting the aggregation of different types of amyloid-prone proteins, with these results supporting the notion that common mechanisms exist for the aggregation of different amyloidogenic proteins and that a generic treatment of conformational diseases is possible.

APA, Harvard, Vancouver, ISO, and other styles

14

Ohlsson, Ingemar. "Stealth tRNAs: Strategies for mining orthogonal tRNA candidates from genomic data." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-253350.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Senate, University of Arizona Faculty. "Faculty Senate Minutes December 3, 2012." University of Arizona Faculty Senate (Tucson, AZ), 2012. http://hdl.handle.net/10150/269272.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Feuk, Lars. "SNP based strategies to study candidate genes for Alzheimer's disease /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-334-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Llaudet, Elena. "Electoral Institutions, Party Strategies, Candidate Attributes, and the Incumbency Advantage." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11579.

Full text

Abstract:

In developed democracies, incumbents are consistently found to have an electoral advantage over their challengers. The normative implications of this phenomenon depend on its sources. Despite a large existing literature, there is little consensus on what the sources are. In this three-paper dissertation, I find that both electoral institutions and the parties behind the incumbents appear to have a larger role than the literature has given them credit for, and that in the U.S. context, between 30 and 40 percent of the incumbents' advantage is driven by their "scaring off" serious opposition.
Government

APA, Harvard, Vancouver, ISO, and other styles

18

Jansson, Lisa, and Emelie Höglund. "Logopeders samtal med närstående till en person med afasi : En samtalsanalys." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119119.

Full text

Abstract:

I institutionella samtal såsom närståendesamtal mellan en logoped, en närstående till en person med afasi och personen med afasi råder en asymmetri gällande maktförhållandet. Asymmetrin som uppstår i det institutionella samtalet kan innebära att samtalsdeltagaren med minst makt upplever ansiktshot. I samtal ses förståelse som en dynamisk process och när förståelsen innebär ett problem i konversationen störs den pågående aktiviteten. Mottagaren kan lösa problemet som uppstått genom att ge talaren en candidate understanding. Hur kommunikativa strategier används i närståendesamtal är ett relativt obeforskat område och ett viktigt område då närståendesamtal är en vanligt förekommande för logopeder. Syftet med föreliggande studie var därför att undersöka ett antal kommunikativa strategier för att få en gemensam förståelse och minska ansiktshot vid delgivning av testresultat och rådgivning i närståendesamtal. Tre närståendesamtal mellan logopeder, närstående och i två fall personer med afasi spelades in, transkriberades och analyserades enligt samtalsanalytiska principer (CA). Två logopeder, tre närstående och två personer med afasi medverkade i studien. Totalt omfattade det inspelade materialet en timma och 37 minuter. Deltagande logopeder fick även fylla i ett frågeformulär. Strategier för avdramatisering och förståelse identifierades. Strategierna delades in i två kategorier; avdramatisering av råd och förmedling av testresultat och candidate understandings för att uppnå förståelse. I studien framkom det att candidate understandings ofta initierades av den närstående. Det framkom även att de positiva testresultaten som förmedlades inte avdramatiserades samt att dessa istället ofta framhävdes och att face threatenings acts vid delgivning av negativa testresultat ofta avdramatiserades med hedging.
In institutional interactions such as conversations between a speech and language therapist, a person closely related to a person with aphasia and the individual with aphasia there is an asymmetry considering the power. The asymmetry arising in institutional interactions may mean that the participant with the least power will experience a face threatening act. Understanding is seen as a dynamic process and when understanding is a problem in the conversation the ongoing activity is disturbed. The receiver can solve the problem by giving the speaker a candidate understanding. How these strategies are used in conversations between a speech and language therapist with a person closely related to a person with aphasia is a relatively unexplored field and an important area which is a common for speech therapists. The aim of the present study was to investigate a number of communication strategies in the conversation with a person closely related to a person with aphasia; how understanding was reached and how face threatening acts were reduced when the speech therapists delivered test results and gave counseling. Three conversations between speech and language therapists, persons closely related to a person with aphasia and in two of the recordings the person with aphasia were recorded, transcribed and analyzed according to principles of Conversation Analysis (CA). Two speech and language therapists, three persons closely related to a person with aphasia and two persons with aphasia participated in the study. In total, the recorded material is one hour and 37 minutes. Participating speech and language therapists also filled in a questionnaire. Strategies for mitigation and understanding were identified. The strategies were divided into two categories; strategies to mitigate FTA:s when delivering the test results and counseling, the other categorie was the use of candidate understandings for gaining an mutual understanding. The study revealed that candidate understandings were often initiated by the person closely related to a person with aphasia. The study also revealed that the test results with positive outcome where not mitigated and often emphasized and test results that could be perceived as negative were mitigated with hedging.

APA, Harvard, Vancouver, ISO, and other styles

19

Flores, Daniel. "Shaping ethos a perspective of the Hillary Rodham Clinton presidential campaign's online rhetorical strategies, January-December 2007 /." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2007. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Vorkapić, Emina. "Targeting vascular remodeling in abdominal aortic aneurysm : To identify novel treatment strategies and drug candidates." Doctoral thesis, Linköpings universitet, Avdelningen för läkemedelsforskning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127502.

Full text

Abstract:

Abdominal aortic aneurysm (AAA) is a degenerative weakening of the aortic wall, mainly affecting elderly men with a prevalence of 4.4-7.7 %. AAA is characterized by medial and adventitial inflammatory cell infiltration associated with vascular remodeling of the extracellular matrix proteins such as collagen and elastin and with phenotypic modulation and loss of vascular smooth muscle cells (VSMCs). Although much research has been performed, the precise cellular and molecular pathways behind these processes are still poorly understood. The overall aim of this thesis was to target signaling pathways that affect vascular remodeling of AAA to potentially identify novel strategies and drug candidates for future treatment of aneurysmal diseases. In order to develop our understanding of the pathophysiology of AAA, we used the angiotensin (Ang) II-induced AAA animal model and human biopsies taken at end-stage of disease to recapitulate key aspects of disease formation. Innate immune receptors such as toll-like receptors (TLRs) are known to regulate immunological processes leading to the formation and progression of vascular disease including AAA. In paper I, we aimed to investigate the role of TLR signaling under the control of the TRIF adaptor protein in the formation of AAA. Human, aneurysmal aortas displayed increased expression of TLR3 and TLR4 in surface of macrophages and T lymphocytes. AngII-induced aneurysm formation was attenuated in mice lacking the Trif gene (ApoE-/-Triʃ-/-), and these knockout mice presented with a more intact medial layer together with a reduced inflammatory response by macrophages and T lymphocytes and reduced levels of pro-inflammatory cytokines, chemokines, and proteases. Our results suggest an involvement of TRIF in the pathophysiology of AAA. Current management of AAA fully depends on imaging and surgical techniques, and drug-based therapies are still mostly ineffective. In paper II, we aimed to investigate the potential protective role of the tyrosine kinase inhibitor imatinib on the molecular mechanism involved in AAA formation. In AngII-infused ApoE-/-mice, 10 mg/kg imatinib per day affected several key features important in aneurysmal formation, including preservation of the medial layer of the VSMCs, reduced infiltrations of CD3ε-positive T lymphocytes, and reduced gene expression of mast cell chymase, resulting in decreased aortic diameter and vessel wall thickness. These results highlight the importance of the tyrosine kinase inhibitor imatinib as a potential drug in the treatment of pathological vascular inflammation and remodeling in conditions such as AAA. In paper III, we aimed to investigate the role of adiponectin in experimentally induced AAA formation in mice. In mice with elevated adiponectin levels, AAA development was inhibited, and this was associated with reduced inflammatory cell infiltration, reduced medial degeneration of VSMCs and of elastin in the aortic vessel wall together with an improved systemic cytokine profile and the attenuation of periaortic adipose tissue (PVAT) inflammation. These results support the protective effect of adiponectin in the remodeling occurring in the aortic wall and in the prevention of AAA. In paper IV, we performed a descriptive study investigating the composition of PVAT adjacent to the aneurysmal aorta. We used immunohistochemistry to identify neutrophils, macrophages, mast cells, and T lymphocytes surrounding necrotic adipocytes in PVAT together with increased gene expression of IL-6 and cathepsin K and S. We also determined the concentrations of pro-inflammatory ceramides in PVAT and found an association to T lymphocytes. These results suggest that inflamed adipose tissue might be a source of proinflammatory cells and mediators that contribute to aortic wall degeneration.

APA, Harvard, Vancouver, ISO, and other styles

21

Stumper, Anne [Verfasser]. "Designing potent PDT drug candidates - development of crucial linking strategies for biomolecule-metal-complex-conjugates / Anne Stumper." Ulm : Universität Ulm, 2018. http://d-nb.info/1150301856/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Walkosz, Barbara Jean 1947. "A micro level analysis of communication strategies utilized in the television advertisements of male and female candidates." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290637.

Full text

Abstract:

American women continue to be severely underrepresented in the number of elected political positions held. One of the obstacles that women face when seeking public office are gender stereotypes which reinforce beliefs that women may be less viable candidates than men. Gender stereotypes influence a range of evaluations about candidates including judgments about their credibility, competency, and communication strategies. This study analyzes communication campaign strategies as one area in which gender stereotyping may influence voters. Television political advertisements are the context for this analysis because of the increased relevance of advertising in imparting candidate image and issue information to the voters. Language Expectancy Theory and literature from the nonverbal communication field provided the theoretical rationale for this study. A micro-level analysis of the verbal and nonverbal communication strategies in political advertising was conducted to determine if these strategies adhered to or countered gender stereotypes. A total of 124 political advertisements of male and female candidates were content analyzed. Results of the study indicate that differences existed in how male and female candidates presented their image to the electorate. Specifically, for the verbal strategies examined, women candidates used less intense language, less humor, less direct attacks, and more prosocial strategies than their male counterparts. However, no differences were found between how men and women made references to autonomy nor were differences identified in their use of opinionated language. For the nonverbal communication strategies, women were coded as having more pleasant voices, and as using more immediate and dominant kinesic cues. No differences were identified in regard to trait characteristics emphasized nor issues mentioned in the ads. The discussion focuses on how these findings can assist scholars in understanding the communication strategies male and female candidates utilized, and if these strategies supported or violated communication stereotypes. The findings of the study can facilitate future research related to understanding how female candidates can increase the persuasive efficacy of their political advertisements.

APA, Harvard, Vancouver, ISO, and other styles

23

Nyhuis, Dominic Verfasser], and Thomas [Akademischer Betreuer] [Gschwend. "Linking voters, parties, and candidate communication : strategic ambiguity in German elections [[Elektronische Ressource]] / Dominic Nyhuis. Betreuer: Thomas Gschwend." Mannheim : Universitätsbibliothek Mannheim, 2014. http://d-nb.info/1075456959/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Nyhuis, Dominic [Verfasser], and Thomas [Akademischer Betreuer] Gschwend. "Linking voters, parties, and candidate communication : strategic ambiguity in German elections [[Elektronische Ressource]] / Dominic Nyhuis. Betreuer: Thomas Gschwend." Mannheim : Universitätsbibliothek Mannheim, 2014. http://d-nb.info/1075456959/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Stokes, Atiya Kai. "The quest for the multiracial mandate African American candidates, white voters, and campaign strategies in state legislative elections /." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1365.

Full text

Abstract:

Thesis (Ph. D.) -- University of Maryland, College Park, 2004.
Thesis research directed by: Government and Politics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

APA, Harvard, Vancouver, ISO, and other styles

26

陳錦榮 and Jin-Rong Chen. "Political Beliefs, Strategies Choice, and Campaign Effectiveness：A Comparative Analysis of Campaign Strategies of the Three Candidates in the 1994 Election for the Mayor of Taipei." 碩士, 東吳大學, 1985. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22085SCU04227002%22.&searchmode=basic.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Gonzalez-Bravo, Jill Elaine. "Investigating the development of possible selves in teacher education: candidate perceptions of hopes, fears, and strategies." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/19170.

Full text

Abstract:

Doctor of Education
Educational Leadership
Trudy A. Salsberry
Today’s teachers must not only be content experts, they must be reflective practitioners competent in both theory and complex learning processes. They must prove capable of constructing classrooms to meet the diverse needs of each child within a culture of global competition and high stakes testing. Beginning teachers are more effective when they enter classrooms with a strong identity and sense of self as teacher. Unfortunately, there is limited understanding of teacher candidate identity development and limited research on effective preparation strategies to strengthen the complex process. A two-staged instrumental-intrinsic case study was developed to collect and analyze candidate possible self-strategies. The investigation gave voice to an often-neglected source of insight, teacher candidates. The theory of possible selves, as proposed by Marcus and Nurius (1986), served as a framework for interviews conducted with thirteen candidates from a private institution in the Midwest. The researcher utilized results from previous applications of the theory to teacher education and extended findings by employing the strategy development process (Ibarra, 1999), an aspect previously unapplied to teacher preparation. Research findings provided insight into participants’ past memories and present motivations. While passive observation appeared to play a minor role in participant strategies, there was a heavy reliance upon future collegial support. Participants also valued intentional effective clinical mentors and suggested structured opportunities to promote dialogue and feedback. Results aligned with previous research that identified modeling of effective instructional strategies as essential to teacher educator quality. However, an additional attribute emerged, affective modeling. Participants attributed affective traits and actions of teacher educators to personal perceptions of collegiality and student-centered instruction. Findings support the utilitarian, investigative, and evaluative qualities of the theory of possible selves. The applied theoretical framework allowed for the assessment of participants’ knowledge, skills, and dispositions, aided in the identification of perceived preparation needs, and served as an appraisal of preparation program effectiveness. The collection and analysis of candidates’ hopes, fears, and process strategies served to inform teacher educator practice and increased understanding in regards to external and internal influences that shape professional identity development.

APA, Harvard, Vancouver, ISO, and other styles

28

Budišová, Martina. "Získavanie a výber zamestnancov A.T. Kearney." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-74397.

Full text

Abstract:

The aim of this thesis is to describe the recruitment and selection process at A.T. Kearney. Thesis is focused on a description of current practices and methods of recruitment and selection process in the company, recommendations how to improve the process are part of the thesis as well. This thesis is divided into two parts. In theoretical part, reader is informed about particular phases and methods of recruitment and selection process. Practical part consists of A.T. Kearney introduction, selection and recruiting process characteristics and analysis and survey. Survey investigates the students' preferences and factors relevant when selecting future employer as representatives of the youngest generation in the working age, Generation Y. At the end, there are the recommendations for improvement of current practices of A.T. Kearney recruitment and selection process.

APA, Harvard, Vancouver, ISO, and other styles

29

Steffan, Dennis [Verfasser]. "Visual Politics : Investigating the Visual Communication Strategies of Political Parties and Candidates from a Longitudinal and Comparative Perspective / Dennis Steffan." Baden-Baden : Nomos Verlagsgesellschaft mbH & Co. KG, 2021. http://d-nb.info/1237168716/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Kinnear, C. J. (Craig John). "Molecular genetic strategies to identify Obsessive-compulsive disorder (OCD) and schizophrenia candidate genes in a South African sub-population group." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/21666.

Full text

Abstract:

Dissertation (PhD)--University of Stellenbosch, 2007.
ENGLISH ABSTRACT: Obsessive-compulsive disorder is a severe, debilitating psychiatric disorder for which the underlying molecular aetiology still remains unclear. Evidence from family studies have suggested that OCD may be caused by a complex interplay of environmental and genetic factors. In order to identify the genetic factors that mediate OCD susceptibility, several genetic association studies have been undertaken, which have yielded inconsistent findings. Moreover, the majority of these studies have focused on a small number of candidate genes that encode components of the serotonin and dopamine neurotransmitter pathways. However, based on the complexity of clinical manifestations observed in OCD, it is likely that its pathogenesis is mediated by a broader complex of interrelated neurotransmitter systems and signal transduction pathways; consequently there is a need to identify and assess novel candidate genes. One method of identifying such novel OCD candidate genes is by utilising knowledge of diseases with phenomenological overlap with OCD, which lend themselves to better genetic dissection through linkage analysis and animal studies. Genetic loci for such disorders, identified though linkage analysis, could potentially harbour novel OCD candidate genes, while genes implicated through animal models may lead to the identification of additional susceptibility genes through delineation of pathways by, for instance, interactome analysis. One such disorder is schizophrenia, which manifests overlap in both symptoms and brain circuits with OCD. In schizophrenia, in addition to several case-control association studies having been performed, linkage data, studies of chromosomal aberrations and animal models have led to the identification of many chromosomal regions that may contain genes involved in its aetiology and thus may also contain OCD candidate genes. In the present investigation, this approach was employed using previously reported schizophrenia susceptibility loci to identify novel OCD candidate genes. All genes residing in each of these loci were catalogued and individually analysed using a battery of bioinformatic techniques in order to assess their potential candidature for OCD susceptibility. These analyses yielded 13 credible OCD candidate genes.Additional candidates were sought using information regarding a well-defined schizophrenia animal model, the heterozygous reeler mouse, that exhibits neurodevelopmental, neuroanatomical and behavioural abnormalities, similar to those displayed by patients with schizophrenia. The phenotype of these mice is caused by a mutation in Reln, which encodes reelin, a large extracellular matrix protein that plays a pivotal role in the ordered migration of neurons during the development of laminar brain structures. The fact that both reelin protein and mRNA levels have been shown to be reduced in post-mortem brain sections of schizophrenic patients, coupled with the observed behaviour and neurochemical similarities between the heterozygous reeler mouse and schizophrenic patients suggests that reelin may be involved in the pathogenesis of schizophrenia and hence also OCD. Furthermore, genes encoding proteins that interact with reelin may thus also be considered plausible candidate genes for both schizophrenia and OCD. For this reason, novel reelin-interacting proteins were sought using the N-terminal reeler-domain of reelin, a domain only found in proteins involved in neuronal migration, as “bait” in a yeast twohybrid screen of a foetal brain cDNA library. Putative reelin ligands were subsequently reevaluated using co-immunopreciptitation and mammalian two-hybrid analysis to corroborate the yeast two-hybrid findings. Results of these analyses showed that WDR47, a WD40-repeat domain protein, interacts with reelin via its reeler-domain; therefore, the gene encoding this ligand protein, as well as RELN itself, was also considered a credible OCD candidate gene. Each of the candidate genes identified using the afore-mentioned strategies were assessed for their potential role in the aetiology of OCD by case-control association studies of a cohort of Afrikaner OCD patients and control individuals. Statistically significant associations were detected for two genes, DLX6 and SYN3, with the disorder. These associations are exciting as they may point to novel mechanisms involved in OCD development. The identification of WDR47 as a novel reelin-interacting protein has significant implications for our understanding of reelin-dependant signalling. Using this protein as the starting point, further novel components of the reelin signalling pathway may be unravelled, an investigation which may lead to the identification of novel roles for reelin in neurodevelopment. Such novel components may, of course, also be considered OCD and schizophrenia candidate genes, which may, in turn, augment the existing knowledge of the pathophysiologies of OCD, schizophrenia and other neurodevelopmental disorders. Taken together, the current study yielded exciting results that warrants follow-up investigation in future. The identification of DLX6 and SYN3 as novel OCD susceptibility genes as well as the identification of WDR47 as a reelin-interacting protein may provide investigators with alternative avenues of research into potential pathological mechanisms involved both in OCD and schizophrenia, which may ultimately lead to alternative pharmacotherapy.
AFRIKAANSE OPSOMMING: Obsessiewe kompulsiewe steuring (OKS) is `n ernstige, verswakkende psigiatriese steuring waarvan die onderliggende molekulêre etiologie steeds onbekend is. Bewyse verkry vanuit familiestudies het voorgestel dat OKS moontlik veroorsaak word deur `n komplekse interaksie van omgewings en genetiese faktore. Om die genetiese faktore te identifiseer wat OKS vatbaarheid veroorsaak, is `n hele aantal genetiese assosiasie studies onderneem, wat teenstrydige resultate gelewer het. Wat meer is, die grootste hoeveelheid van hierdie studies het gefokus op `n klein aantal kandidaatgene wat vir komponente van die serotonien en dopamine neurotransmittor weë enkodeer. Dit is egter, gebaseer op die kompleksiteit van die kliniese manifestasies wat waargeneem word in OKS, heel moontlik dat die patogenisiteit van die siekte bemiddel word deur `n breër kompleks van interverwante neurotransmittor sisteme en seintransduksie weë. Daar is dus `n behoefte na die identifikasie en ondersoek van nuwe kandidaatgene. Een metode om sulke nuwe OKS kandidaatgene te identifiseer, is deur die gebruik van bestaande kennis oor siektes wat fenomenologiese ooreenkomste het met OKS, siektes wat makliker geneties ontleed kan word deur koppelingsanalises en dierestudies. Genetiese lokusse vir sulke versteurings, geïdentifiseer deur koppelingsanalises, het die potensiaal om nuwe OKS kandidaatgene in te sluit, terwyl gene wat geïmpliseer word deur dierestudies mag lei tot die identifisering van bykomende vatbaarheidsgene deur die ondersoek van weë deur, byvoorbeeld, interaktoom analises. `n Voorbeeld van so `n versteuring is skisofrenie, wat in manifestasie oorvleuel in beide simptome en breinstroombane met OKS. In skisofrenie het, addisioneel tot verskeie geval-kontrole assosiasiestudies wat gedoen is, koppelingsdata, studies van chromosomale afwykings en dierestudies gelei tot die identifikasie van verskeie chromosomale gebiede wat gene mag bevat wat betrokke kan wees in die etiologie van die siekte, en dus ook OKS kandidaatgene mag bevat. In die huidige ondersoek is hierdie benadering gevolg en is gebruik gemaak van voorheen gerapporteerde skisofrenie vatbaarheidslokusse om nuwe OKS kandidaatgene te identifiseer. Alle gene wat in hierdie lokusse voorkom is gekatalogiseer en individueel geanaliseer deur gebruik te maak van `n battery van bioinformatika tegnieke om hul potensiaal as kandidate vir OKS vatbaarheid te bepaal. Hierdie analise het 13 geloofwaardige OKS kandidate opgelewer. Addisionele kandidate is gesoek deur inligting van `n goed gedefinieerde skisofrenie dieremodel te gebruik, naamlik die heterosigotiese “reeler” muismodel, wat neuro-ontwikkelings-, neuroanatomiese- en gedragsabnormaliteite vertoon, soortgelyk aan dié wat voorkom by pasiënte met skisofrenie. Die feit dat daar aangetoon is dat beide reelin protein en bRNS vlakke verlaag is in post-mortem brein seksies van skisofrenie pasiënte, gekoppel aan die gedrags- en neurochemiese ooreenkomste wat gesien word tussen heterosigotiese “reeler” muise en skisofrenie pasiënte, stel voor dat reelin betrokke is by die patogenese van skisofrenie en dus ook OKS. Vir hierdie rede is nuwe proteïene gesoek wat `n interaksie met reelin toon, deur gebruik te maak van die N-terminale reeler-domein van reelin, `n domein wat slegs gevind word in proteïene wat betrokke is by neuronale migrasie, as “aas” in `n gis-twee-hibried sifting van `n fetale brein cDNS biblioteek. Vermeende reelin ligande is vervolgens herevalueer deur gebruik te maak van koimmunopresipitasie en soogdier twee-hibried analises om die gis-twee-hibried bevindings te bevestig. Resultate van hierdie analises het getoon dat daar interaksie is tussen WDR47, `n WD40-herhalingsdomein protein, met reelin via sy reeler-domein. Die geen wat hierdie ligand protein enkodeer, sowel as RELN self, is dus beskou as ‘n geloofwaardige OKS kandidaatgeen. Elkeen van die kandidaatgene wat geïdentifiseer is deur gebruik te maak van bogenoemde strategieë is ondersoek vir `n potensiële rol in die etiologie van OKS deur gebruik te maak van geval-kontrole assosiasie studies met `n groep Afrikaner OKVS pasiënte en kontrole individue. Statisties-betekenisvolle assosiasies met die versteuring is vasgestel vir twee gene, DLX6 en SYN3. Hierdie assosiasies is opwindend aangesien hul nuwe meganismes betrokke by OKS ontwikkeling mag aantoon. Die identifikasie van WDR47 as ‘n nuwe protein wat interaksie met reelin vertoon, het betekenisvolle implikasies vir die verstaan van reelin-afhanklike seining. Deur hierdie proteïn as die beginpunt te gebruik kan vêrdere nuwe komponente van die reelin seinweg ontdek word, `n ondersoek wat mag lei tot die identifisering van nuwe funksies vir reelin in neuro-ontwikkeling. Sulke nuwe komponente mag, natuurlik, ook in aanmerking kom as OKS en skisofrenie kandidaatgene, wat op sy beurt weer die bestaande kennis van die patofisiologie van OKS, skisofrenie en ander neuro-ontwikkelings versteurings mag verbreed. In samevatting, hierdie studie het opwindende resultate gelewer wat opvolgondersoeke in die toekoms regverdig. Die identifikasie van DLX6 en Syn3 as nuwe OKS vatbaarheidsgene, sowel as die identifisering van WDR47 as ‘n protein wat interaksie vertoon met reelin, mag aan navorsers alternatiewe navorsingsweë voorsien om die moontlike patologiese meganismes wat betrokke is by beide OKS en skisofrenie te ondersoek, wat uiteindelik mag lei tot alternatiewe farmakoterapie.

APA, Harvard, Vancouver, ISO, and other styles

31

Ribeiro, Maria Celeste de Carvalho Ressiguier. "Apoio multicritério à decisão na seleção de projetos de pesquisa candidatos ao portfólio do IFF." Universidade Federal Fluminense, 2014. https://app.uff.br/riuff/handle/1/849.

Full text

Abstract:

Submitted by Marcia Silva (marcia@latec.uff.br) on 2015-10-29T13:57:52Z No. of bitstreams: 1 dissert Maria Celeste de Carvalho Ressiguier Ribeiro.pdf: 12817772 bytes, checksum: b23ae40921877e1329e6a70604a1f9fe (MD5)
Made available in DSpace on 2015-10-29T13:57:52Z (GMT). No. of bitstreams: 1 dissert Maria Celeste de Carvalho Ressiguier Ribeiro.pdf: 12817772 bytes, checksum: b23ae40921877e1329e6a70604a1f9fe (MD5) Previous issue date: 2014-06-14
Este trabalho desenvolve um modelo para a seleção de propostas de projetos de pesquisa, básica e aplicada, com o apoio de método multicritério à decisão, já existente. Como método multicritério, é aplicado o Analytic Hierarchy Process (AHP), combinando as mensurações relativa e absoluta, para ajudar os gestores do IF Fluminense, na área de pesquisa. O modelo proposto visa à priorização e seleção de projetos que atendam, satisfatoriamente, aos propósitos da instituição e aos requisitos exigidos para cada pesquisa científica. Trata-se de um problema complexo de decisão, que envolve a avaliação de um grande número de projetos julgados em vários critérios, em sua maioria, qualitativos. O problema é tratado em duas etapas de seleção. A primeira etapa visa à seleção dos projetos mais satisfatoriamente alinhados aos objetivos da instituição. Os projetos selecionados na primeira etapa servem de entrada para a segunda etapa, onde tais projetos são pontuados segundo os requisitos da pesquisa. Em cada etapa utiliza-se método AHP aplicando a mensuração relativa e absoluta. O AHP mensuração relativa é aplicado para determinar o peso de contribuição dos critérios para atingimento do objetivo geral. A mensuração absoluta serve para avaliar os projetos em cada critério. Finalmente, cada projeto é pontuado com a soma ponderada que consiste no somatório dos produtos do peso relativo de cada critério pela mensuração absoluta atribuída ao projeto no mesmo critério. Para tanto, utilizou-se como procedimento de pesquisa o estudo de caso, baseando-se num estudo exploratório. O trabalho envolveu pesquisa bibliográfica sobre diversos assuntos, tais como, gerenciamento de portfólio de projetos, apoio multicritério à decisão e aplicação dos métodos de apoio multicritério à decisão na seleção de projetos, a fim de conhecer o estado de arte sobre a utilização de tais métodos na seleção de projetos. Assim como, fez uma breve revisão da literatura sobre os critérios de avaliação considerados na pesquisa científica, a fim de ajudar na estruturação dos critérios utilizados na avaliação dos projetos. Também, baseou-se em pesquisa documental e entrevistas não estruturadas, a fim de compreender melhor o problema. A autora concluiu que o modelo proposto contribuiu para melhorar o processo decisório e proporcionou um processo de seleção mais simples e eficaz. O resultado do trabalho permitiu a escolha de projetos baseado na melhor contribuição de tais projetos para o alcance dos objetivos institucionais e para o melhor cumprimento dos requisitos exigidos para cada pesquisa.
This work develops a model for selection of proposals for research projects, basic and applied, with the support of multi-criteria decision method, already exists. How multicriteria method is applied Analytic Hierarchy Process (AHP), combining the relative and absolute measurements, to help managers of IF Fluminense, in the search area. The proposed model aims at prioritizing and selecting projects that may match satisfactorily the purposes of the institution and the requirements demanded for each scientific research. This is a complex decision problem, which involves the evaluation of a large number of projects judged on several criteria, mostly qualitative. The problem is treated in two stages of selection. The first step aims at selecting projects more satisfactorily aligned to the objectives of the institution. The projects selected in the first stage serve as input to the second stage, where such projects are scored according to the requirements of the research. At each step, it uses AHP applying the relative and absolute measurement. The AHP relative measurement is used to determine the weight of contribution of the criteria for achieving the overall goal. The absolute measurement serves to evaluate the projects in each criterion. Finally, each project is scored with a weighted sum consisting of the sum of the products of the relative weight of each criterion for absolute measurement assigned to the project on the same criteria. For this, we used the procedure as a research case study, based on an exploratory study. The work involved bibliographic research on various subjects such as project portfolio management, multicriteria decision support and application of the methods of multicriteria decision support in the selection of projects in order to know the state of art about the use of such methods in selecting projects. Just as, made a brief literature review on the evaluation criteria used in scientific research, in order to help in structuring the criteria utilized in the evaluation of projects. Also drew on documentary research and unstructured interviews in order to better understand the problem. The author concluded that the proposed model contributed to improving the decision making process and provided a simpler and more effective selection. The result of the work allowed the choice of projects based on the best contribution of such projects to achieve the institutional goals and to better compliance with requirements demanded for each research project.

APA, Harvard, Vancouver, ISO, and other styles

32

MOSCARELLI, Angelo. "OPERATIONAL STRATEGIES FOR IMPROVING THE COMPETITIVENESS OF THE VALLE DEL BELÌCE SHEEP BREED." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/499456.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

MAS, CHRISTOPHE. "Clonage et caracterisation de genes impliques dans la proliferation des neuroblastes du telencephale un strategie d'identification de genes candidats a des maladies du neurodeveloppement." Paris 7, 1999. http://www.theses.fr/1999PA077156.

Full text

Abstract:

Pour identifier des genes impliques dans les maladies complexes du neurodeveloppement, nous avons developpe une strategie qui associe une hypothese physiopathologique a une localisation candidate. En effet, des genes impliques dans la proliferation des neuroblastes du telencephale ont ete trouves mutes chez des enfants atteints de retard mental. On peut donc faire l'hypothese que des genes qui s'expriment lors de cette etape critique pourraient etre a l'origine d'autres maladies du neurodeveloppement telles que la microcephalie ou l'autisme. Afin d'isoler ce type de genes, nous avons par la technique du differential display (dd-rt pcr) compare les populations d'arn messagers du telencephale de la souris a 10. 5 jours embryonnaires a celles de regions plus posterieure du cerveau embryonnaire qui sont plus avancees dans leur differenciation. Par une approche de genomique comparative inter-especes, les orthologues humains des genes ainsi isoles ont ete identifies, puis positionnes sur le genome au moyen des informations issues de collections d'hybrides somatiques d'irradiation. Cette strategie nous a permis d'isoler 50 cdnas candidats dont 42% correspondent a des genes connus et 58% representent de nouveaux genes. Parmi ces genes, cinq sont positionnes sur des locus lies au retard mental et deux sur des locus de susceptibilite a l'autisme. Ainsi, nous avons clone un nouveau gene, rp42, localise au niveau du locus 6q16 du chromosome 6. Par cette approche, nous avons egalement clone le gene codant une immunophiline, fkbp25, dont nous avons pu montrer, sur un modele de culture in vitro de cellules souches de telencephale, que la localisation intra-cellulaire change avec la differenciation neuronale. Enfin, ce travail a permis de cloner un nouveau gene, nibrin. L'orthologue humain de ce gene est a l'origine du syndrome de nijmegen, une maladie autosomale recessive qui se caracterise par une immunodeficience et dont le phenotype neurologique est une microcephalie.

APA, Harvard, Vancouver, ISO, and other styles

34

Palé, Titi Eri Aramatou. "Paysage électoral et stratégies de communication des candidats à la présidentielle de 2010 en Côte d'Ivoire." Thesis, Bordeaux 3, 2017. http://www.theses.fr/2017BOR30020.

Full text

Abstract:

En 2010, les Ivoiriens organisaient une élection présidentielle au sortir d’une décennie de guerre civile. Depuis lors, ces élections défraient la chronique, en raison de leur issue critique : crise postélectorale meurtrière en 2011, réconciliation nationale poussive et, depuis 2016, mutineries dans les rangs d’une armée composite et de transition. La présente étude considère ces élections ivoiriennes de 2010 comme un objet d’étude scientifique et se consacre à la communication politique de campagne de trois « grands candidats » : Henri Konan Bédié du Parti Démocratique de Côte d’Ivoire (PDCI), Laurent Gbagbo de la Majorité Présidentielle (LMP) et Alassane Ouattara du Rassemblement Des Républicains (RDR). L’objectif scientifique est ici de déterminer les différents axes de communication partisane, qui éclairent le profil sociopolitique et le comportement de l’électeur ivoirien aux présidentielle de 2010. Plus spécifiquement, nos investigations sont consacrées, d’une part, à la détermination de l’électorat ivoirien dans sa composition sociale, politique et culturelle, mais aussi psychosociologique. Cet électorat est ici défini en termes d’intentions de vote, ou de motivation à voter pour tel ou tel candidat. D’autre part sont observés les moyens de communication utilisés par ces candidats majeurs qui deviennent des points structurants du champ politique ivoirien en s’endossant aux partis mandataires. Dans cette confrontation électorale pour capturer la majorité des voix interfèrent des représentations et des imaginaires politiques très marqués, qui consacrent ces candidats en challengers de la vie politique nationale et des sondages du moment. Ces enjeux affectent et différencient les stratégies de communication politique de campagne, que la thèse analyse en collectant les données et les ressources qui les influencent en sourdine et structurent autant les discours que les pratiques médiatiques des candidats étudiés. En clair, le contexte électoral de 2010 et ses déterminants sociohistoriques forgent les stratégies de communication et le comportement médiatique des candidats majeurs
At the end of the year 2010, the Ivorians organized a presidential election after a decade of civil war. Since then, these elections are still in the news because of their critical outcome: murderous post-electoral crisis in 2011, complicated national reconciliation and, since the year 2016, mutinies in the ranks of a composite and transitional army. This study considers the Ivorian presidential elections of 2010 as a social sciences study subject and is devoted to the political campaign communication of three "great candidates" : Henri Konan Bédié of the Democratic Party of Côte d'Ivoire (PDCI), Laurent Gbagbo of the Presidential Majority (LMP) and Alassane Ouattara of the Rally of Republicans (RDR). The scientific purpose here is to determine the different axes of partisan communication, which illuminate the socio-political profile and behavior of the Ivorian voter in the 2010 presidential election. More specifically, our investigations are devoted, on the one hand, to the determination of the Ivorian electorate in its social, political and cultural composition, but also psycho-sociological dimension. This electorate is here defined in terms of voting intentions, or motivation to vote for a particular candidate. On the other hand are observed the means of communication used by these major candidates who become structuring points of the Ivorian political field by endorsing the mandatory parties. In this electoral confrontation to capture the majority of voices, the study shows how interfere a very strong political representations and imaginings, which consecrate these candidates into challengers of national political life and polls of the moment. These issues affect and differentiate campaign political communication strategies, which the thesis analyzes by collecting data and resources that influence them below and structure both the speeches and the media practices of the candidates studied. Clearly, the electoral context of 2010 and its sociohistorical determinants forge communication strategies and the media behavior of major candidates

APA, Harvard, Vancouver, ISO, and other styles

35

Roivainen, J. (Jenni). "“I will bring back jobs. You can’t bring back jobs.”:polarizing strategies used by the presidential candidates Hillary Clinton and Donald Trump in the United States presidential debates of 2016." Master's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201709142900.

Full text

Abstract:

This study examines the polarization strategies used in the United States presidential debates of 2016. The data consists of the presidential candidates Hillary Clinton, the nominee of the Democratic Party, and Donald Trump, the nominee of the Republican Party, and the three presidential debates between Clinton and Trump. The televised debates took place in September and October 2016. The debates are analyzed using the theoretical framework of political discourse analysis and ideological discourse analysis. The candidates display polarization by varying the use of pronouns; the first-person singular pronoun I is used when the candidates emphasize their own role in taking care of the country, as well as polarizing themselves with the other candidate, whereas the first-person plural pronoun we is used in order to appeal to the American people and to show that the candidates are part of the same ideological group as the Americans are. Furthermore, as the candidates are part of different political parties, they have different ideological views, which they also acknowledge during the debates. Both Clinton and Trump also attack the other’s suggestions and in turn defend their own ideas. Moreover, the candidates position each other by their experience and past; Clinton has decades of experience in politics, which she uses as her advantage, whereas Trump’s history is in business, which he in turn uses as his strength. However, Trump uses Clinton’s experience against her and claims that she has been an ineffective politician, and Clinton in turn uses Trump’s history against him. Furthermore, when constructing a negative representation of other, the candidates emphasize the other’s negative aspects and their own positive features, as well as de-emphasizing the other’s positive aspects and their own negative features. Moreover, rhetorical devices, such as repetition, metaphors, personification, hyperbole and number game, are used in order to emphasize the polarization between the candidates. Even though the outcome of the elections was not the main focus of this study, it can be argued that Trump offered people a fresh approach to presidency, which was in fact emphasized by using the studied polarization strategies
Tämä tutkimus tarkastelee polarisaation strategioita, joita käytettiin Yhdysvaltojen presidentinvaaleissa vuonna 2016. Tutkimuksen aineisto koostuu demokraattisen puolueen presidenttiehdokkaasta Hillary Clintonista ja republikaanisen puolueen presidenttiehdokkaasta Donald Trumpista, ja heidän välisistä kolmesta presidenttiväittelyistään. Televisioväittelyt järjestettiin syyskuussa ja lokakuussa vuonna 2016. Väittelyt analysoidaan käyttäen poliittista diskurssianalyysia ja ideologista diskurssianalyysia. Ehdokkaat korostavat heidän välistä vastakkainasetteluaan vaihtamalla käyttämiään pronomineja; yksikön ensimmäistä persoonaa, minä, käytetään, kun ehdokkaat korostavat omaa rooliaan maansa huolehtimisesta ja asettaessaan itsensä vastakkain toisen ehdokkaan kanssa. Monikon ensimmäistä persoonaa, me, käytetään, kun ehdokkaat vetoavat Amerikan kansalaisiin, ja kun ehdokkaat näyttävät, että ovat osa samaa ideologista ryhmää kuin amerikkalaiset ovat. Lisäksi, koska ehdokkaat ovat osana eri poliittisia puolueita, heillä on myös erilaiset ideologiset näkemykset, minkä he myös tuovat esille ja myöntävät väittelyiden aikana. Sekä Clinton että Trump myös hyökkäävät toisen ehdotuksia vastaan ja vuorostaan puolustavat omia ideoitaan. Ehdokkaat lisäksi arvioivat toisiaan kokemuksen ja historian mukaan; Clintonilla on vuosikymmenten kokemus politiikassa, mitä hän käyttää vahvuutenaan, kun taas Trumpin kokemus ja historia on liike-elämässä, mitä hän taas käyttää etunaan. Trump kuitenkin käyttää Clintonin kokemusta tätä vastaan ja väittää, että Clinton on ollut tehoton poliitikko, ja Clinton vuorostaan käyttää Trumpin historiaa tätä vastaan. Kun ehdokkaat rakentavat negatiivista kuvaa toisesta, he korostavat toisen negatiivisia puolia ja omia positiivia piirteitään samaan aikaan kun vähättelevät, tai eivät kiinnitä huomiota, toisen positiivisiin puoliin ja omiin negatiivisiin piirteisiin. Väittelyissä käytetään lisäksi retorisia keinoja, kuten toistoa, metaforia, personifikaatiota, liioittelua ja numeropeliä korostamaan ehdokkaiden vastakkainasettelua. Vaikka vaalien tulos ei ollut tämän tutkimuksen keskeisin asia, voidaan väittää, että Trump tarjosi kansalle raikkaan lähestymistavan presidenttiyteen, mikä myös korostui tutkituissa polarisaation strategioissa

APA, Harvard, Vancouver, ISO, and other styles

36

Assmann, Gabriela. "POLÍTICA E PARTICIPAÇÃO: ANÁLISE DAS ESTRATÉGIAS COMUNICACIONAIS UTILIZADAS PELA CANDIDATA MANUELA D ÁVILA NA CAMPANHA À PREFEITURA DE PORTO ALEGRE EM 2012." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/6352.

Full text

Abstract:

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
This dissertation starts from the notion that we live in a mediatized and networked society, factor that modifies social relations and the logics of various fields, including communication and politics. In this sense, the present research purposes to investigate in which way certain communication strategies applied in the campaign of the candidate Manuela D‟Ávila for Mayor of Porto Alegre, in 2012, affect political participation. So, our search problem is: in what measure and in which manner the communication strategies used by candidate Manuela D‟Ávila‟s campaign enabled political participation? Therefore, the main objective of the study is to inquire the relation between the communication strategies of political participation promotion undertaken by the campaign and the participation that, effectively, was achieved. The specific objectives consist in: to analyze the communication strategies applied by candidate Manuela D‟Ávila in Porto Alegre‟s municipal elections‟ campaign of 2012 to promote political participation; to comprehend the specificities of the strategies that seek to encourage political participation on the internet; to observe, comparatively, the distinct types of strategies: conventional and for internet. To achieve these goals, we did, at first, a bibliographic review from the notions that guide the research. Afterwards, we worked in a case study of candidate Manuela D‟Ávila‟s campaign, embracing, as developer units of analysis, the strategies from Bairro a Bairro and the website Novas Ideias POA. The data that compose the corpus of study were collected by in-depth interviews, documentations and observation.
Esta dissertação parte da noção de que vivemos em uma sociedade midiatizada e em rede, fator que modifica as relações sociais e as lógicas dos mais diversos campos, inclusive da comunicação e da política. Nesse contexto, a presente pesquisa se propõe a investigar de que maneira determinadas estratégias comunicacionais empregadas pela campanha da candidata Manuela D‟Ávila à prefeitura de Porto Alegre, em 2012, afetam a participação política. Assim, nosso problema de pesquisa é: em que medida e de que modo as estratégias comunicacionais utilizadas na campanha da candidata Manuela D‟Ávila possibilitaram a participação política? Portanto, o objetivo geral do estudo é averiguar a relação existente entre as estratégias comunicacionais de promoção à participação política empreendidas pela campanha e a participação que, efetivamente, foi alcançada. Os objetivos específicos consistem em: analisar as estratégias comunicacionais de promoção à participação política empregadas pela candidata Manuela D‟Ávila na campanha de 2012 à prefeitura de Porto Alegre; compreender as especificidades das estratégias que buscam fomentar a participação política na internet; observar, comparativamente, os tipos distintos de estratégias: convencional e para internet. Para alcançar essas metas, fizemos, primeiramente, uma revisão bibliográfica a partir das noções que movimentam a pesquisa. Depois, realizamos um estudo de caso da campanha da candidata Manuela D‟Ávila, adotando, como unidades incorporadas de análise, as estratégias do Bairro a Bairro e do website Novas Ideias POA. Os dados que compõem o corpus do estudo foram coletados por meio de entrevistas em profundidade, documentação e observação.

APA, Harvard, Vancouver, ISO, and other styles

37

Adiguzel, Ozge. "Institutional And Attitudinal Determinants Of Women&#039." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605561/index.pdf.

Full text

Abstract:

This thesis analyses the process of women&rsquo
s legislative recruitment in Turkey by focusing on the interaction among the certain features of the Turkish political system including the attitudes of the party elite toward the enhancement of women&rsquo
s political representation. It has been demonstrated in earlier studies that one of the reasons behind women&rsquo
s low level of parliamentary representation in Turkey is the fact that the selectors in the political parties fail to support women candidates adequately in the elections. Related to that, women&rsquo
s legislative recruitment is also likely to be impeded by the unsupportive nature of the main dynamics of political system such as political culture, party system and the v electoral system. Considering the fact that these institutional and attitudinal factors are highly inter-related with each other, the insufficient number of women candidates nominated by the major social democratic party, the Republican People&rsquo
s Party in the 1990s, including the latest national elections on November 3rd, 2002 calls for an analysis of not only the attitudes of the RPP selectors toward positive discrimination mechanisms such as the quotas for women but also of the relevant party institutional factors rooted in the Turkish political system. The study contends that the RPP&rsquo
s women-friendly party culture and selectors&rsquo
positive perspectives towards women&rsquo
s political integration are not sufficient factors for the promotion of women&rsquo
s legislative recruitment within the party. The weakness of the intra-party democracy in the RPP which is particularly the result of the oligarchic structure and the problems with institutionalization significantly impede women&rsquo
s legislative recruitment within the party. The study has found that the low level of women&rsquo
s legislative recruitment in the RPP is a consequence of the interaction between the institutional and attitudinal factors within the RPP which perpetuates patriarchal elite oligarchy in the nomination process. The documented gap between the RPP&rsquo
s party rhetoric and practice in this study is found as the reflection of the party&rsquo
s problems in internalizing social democratic values.

APA, Harvard, Vancouver, ISO, and other styles

38

Fontugne, Jacqueline. "Basal/Squamous Subtype of Bladder Cancer : Mechanisms of Progression, Transcriptional Regulators and New Therapeutic Strategies A Consensus Molecular Classification of Muscle-invasive Bladder Cancer Gene Expression Dynamics During Progression to Basal/Squamous Bladder Cancer in the BBN Mouse Model Reveals a Switch From EGFR to FGFR1 Dependency in Sarcomatoid Tumors Enhancer Profiling of Bladder Cancer Reveals a Candidate Basal/Squamous-Specific Core Regulatory Circuitry Tertiary Lymphoid Structures Marker CXCL13 Is Associated With 1 Better Survival for 2 Patients With Advanced-Stage Bladder Cancer Treated With Immunotherapy." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL030.

Full text

Abstract:

Le cancer de la vessie est de mauvais pronostic au stade infiltrant le muscle (TVIM). Les TVIM de sous-type basal/squameux (Ba/Sq) peuvent évoluer vers le variant sarcomatoïde et sont de très mauvais pronostic.Les mécanismes de progression des tumeurs non invasives vers une TVIM basale sont difficiles à étudier chez l’homme du fait de son caractère agressif. Dans une première partie, nous avons donc utilisé un modèle murin carcinogène-induit de TVIM Ba/Sq pour étudier l’évolution de l’expression génique depuis les stades pré-invasifs menant au TVIM Ba/Sq et au variant sarcomatoïde. Nous avons déterminé que les tumeurs précoces présentent d’emblée des caractères du phénotype Ba/Sq et qu’il existe des groupes de gènes d’évolution coordonnée au cours de la progression, avec une pertinence en pathologie humaine. L’étude des cas sarcomatoïdes a révélé une ressemblance au variant sarcomatoïde humain et l’existence d’une bascule de signalisation de l’EGFR vers une activation de la voie de FGFR1 lors de la dé-différenciation sarcomatoïde, corrélée à la transition épithélio-mésenchymateuse (TEM). Ce résultat indique un potentiel bénéfice des inhibiteurs des FGFRs pour les tumeurs sarcomatoïdes, avec TEM et/ou exprimant fortement FGFR1.De plus, les régulateurs transcriptionnels clés du phénotype Ba/Sq sont méconnus. Une méthode pour identifier de tels régulateurs consiste en l’identification d’un circuit de facteurs de transcriptions (FT) auto-régulés et contrôlés par des super-enhancers (SE), larges régions génomiques régulatrices jouant un rôle dans l‘identité cellulaire. Dans une deuxième partie, nous avons identifié les régions SE dans des tumeurs primaires et des lignées de cancer de vessie, y compris du sous-type Ba/Sq, par la réalisation d’une ChIP-seq H3K27ac, modification d’histone caractéristique des régions SE. Nous avons démontré que le profil chromatinien H3K27ac est associé aux sous-types moléculaires et avons identifié les SE spécifiques du sous-type Ba/Sq. En utilisant l’algorithme CRCmapper, nous avons identifié des FT candidats pouvant réguler le phénotype basal, tels que RUNX2 ou KLF7. Une validation de ces candidats dans des lignées cellulaires de cancer de vessie sera nécessaire.Ce travail permet de mieux caractériser le sous-type Ba/Sq des cancers de vessie et ouvre la voie à de nouvelles stratégies thérapeutiques
Bladder cancer is frequent, with poor prognosis at the muscle-invasive stage (MIBC). The basal/squamous (Ba/Sq) subtype of MIBC can progress to the sarcomatoid variant and has very poor outcome.Owing to their aggressive phenotype, Ba/Sq tumors are often diagnosed at advanced stages, hampering the study of disease progression in humans. In a first part, we thus utilized a carcinogen-induced mouse model of Ba/Sq MIBC to explore the molecular changes occurring from pre-invasive stages, to Ba/Sq MIBC, to the sarcomatoid variant. We determined that pre-invasive stages already harbor Ba/Sq features and identified clusters of genes with co-expression changes during progression, with relevance to human disease. A focus on sarcomatoid cases revealed their close resemblance to the human sarcomatoid counterpart. We identified an EGFR/FGFR1 switch during sarcomatoid dedifferentiation, correlated with epithelial-mesenchymal transition (EMT). This finding indicates that patients with sarcomatoid, EMT- or FGFR1-high tumors may benefit from FGFR inhibitors.Additionally, the master transcription factors (TFs) controlling the Ba/Sq phenotype are poorly understood. One approach to identify such TFs is to pinpoint to those forming a core regulatory circuitry (CRC) driven by super-enhancers (SE), i.e., large genomic regulatory domains with a major role in cell identity. In a second part, we identified such SEs by performing ChIP-seq for H3K27ac, a typical histone modification found in SE regions, in bladder cancer primary tumors and cells lines, including of Ba/Sq subtype. We determined that distinct H3K27ac profiles are associated with molecular subtypes and identified subtype-specific SEs. CRC analysis using the CRCmapper algorithm nominated potential master TFs driving the Ba/Sq phenotype, including RUNX2 and KLF7. Further functional validation of these candidates in bladder cancer cell lines is necessary.Overall, this work furthers our understanding of Ba/Sq MIBC and provides potential new therapeutic strategies

APA, Harvard, Vancouver, ISO, and other styles

39

King, Aaron. "Unfolding Ambition: Strategic Candidacy Decisions in Senate Primary Elections." Diss., 2013. http://hdl.handle.net/10161/7147.

Full text

Abstract:

Theories of ambition have taught us that higher offices are valuable commodities to certain politicians, and under the right circumstances, the benefits of running for an office outweigh the associated risks. Yet some ambitious politicians emerge as candidates while others do not. In this dissertation, I present a Theory of Strategic Candidacy Decisions to explain how primary elections unfold. With new comprehensive data on the timing of candidacy decisions, I test several hypotheses regarding the determinants of electoral and fundraising success, the timing of strategic candidacy decisions, the interactions of prospective officeholders, and the impact of strategic retirements on primary races for the United States Senate. Using both qualitative and quantitative tools, including event history techniques to capture the complex dynamics of primaries, I find that potential candidates interact with one another and the unique political context within each race and emerge from the pool of potential candidates in systematic ways. In the end, the strategic behavior of ambitious politicians has implications for the slate of candidates available to the electorate and ultimately, on the quality of representation between legislators and constituents.

Dissertation

APA, Harvard, Vancouver, ISO, and other styles

40

Boatright, Robert G. "Invisible politics : the ideological strategies of congressional challengers /." 1999. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9951764.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Chen, wei-chun, and 陳薇淳. "A Case Study on Crisis Communication Strategies for Candidates in ElectionCam paign—The Candidate of Taipei City Major Election in 2006 for Example: Hao Long-Bin." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/44182443743143038282.

Full text

Abstract:

碩士
大葉大學
人力資源暨公共關係學系碩士在職專班
95
The research of crisis communication is to explore the relationship among situation, policies, and effects, such that the appropriate corresponding policy can be well applied to different crisis situations. Then, the target of recovering image can be achieved. With regard to the view point of rhetorical, the study utilizes the response communication model by Bradford and Garrett in 1955 and the image recovering policy by Benoit in 1997, both of which serve as the analysis frame-work. Besides, the Situation Crisis Communication Theory (SCCT) is employed to check the effect of recovering the candidate’s image. For the example of Hao that run in the 2006 Taipei city major election, the study discusses the relationships among the crisis situations, response policies, and effects. In the work, multi methods of collecting data are applied, such as the second-hand data (the reports in media) and questionary investigation. As to the research method, it employs the content analysis method and quantification research. Accordingly, the involved corresponding policies and the effects of recovering image can be examined, while encountering the crisis events in the election for Hao. Several points can be given from the investigation of the study, as follows. 1.Aimed at the events that bring the voters a serious aversion, a candidate tends to employ the sub-policy of counterat-tack; as for those events that just cause light aversion, a candidate then prefers the sub-policy of revealing his advantages and looking for favors from others.2. “To reduce the influence from the crisis” and “to deny” is the mostly general policies used by candidates3. In case that a candidate applies the image recovering policy suggested by the scholars, he can reach neuter-above policy effects.4. For the vot-ers, the variances, including the candidate’s past expression, the authenticity of the accusing evidence presented by the opposite, their aversive level towards the crisis incidents, causes recovering image and the crisis response effects great influence.5. The voters’ recognition towards the candidate’s handling ability of a crisis greatly influences the latter’s image recovering effects.

APA, Harvard, Vancouver, ISO, and other styles

42

Baptista, De Carvalho Sofia. "Downstream strategies for VLPs as candidate universal vaccine for Influenza." Doctoral thesis, 2018. http://hdl.handle.net/10362/93880.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Pressel, Robert Jacob. "Crashing the party: strategic candidate entry in partisan primaries for the U.S. House." Thesis, 2016. https://hdl.handle.net/2144/17698.

Full text

Abstract:

By selecting the pool of candidates that voters can choose from in the general election, party nominating contests play a fundamental role in determining the outcome of elections at all levels of government. However, past research has indicated that, due largely to the incumbency advantage, primary competition has declined dramatically since the institution’s origins. Strategic entry theory suggests that skilled candidates, often those holding prior political office, wait for the most opportune chance to run for higher office. To test this hypothesis, I collected data on all congressional districts and candidates from the 2014 midterm elections. Using candidate information gathered from the Federal Election Commission and other candidate databases, district level demographic and political data, and incumbent statistics, I developed a model using the individual and structural factors to predict when an experienced politician will challenge an incumbent within their own party. The data show that strong intraparty challenges are rare compared to cross-party challenges, and that the most ideologically centrist incumbents, of either party, are the most likely to be “primaried” by an experienced and ambitious challenger.

APA, Harvard, Vancouver, ISO, and other styles

44

Chaloupková, Gabriela. "Marketing strategy of recruitment and retention of IT candidates in the market of Brno." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-428593.

Full text

Abstract:

This master thesis is conducted to address the most discussed topics in recruitment of IT candidates. In 2018 the market with IT candidates in Brno is overheated and there is a big competition between the IT companies. In the theoretical part of this master thesis most discussed topics are introduced and explained, such as remuneration, benefits, forms of recruiting candidates and the recruitment process. HR marketing and recruitment practices were incorporated into the marketing terminology of the extended marketing mix. Practical part consisting of in-depth interviews, findings from related expert seminars and quantitative research focuses on topics discussed in the theoretical part and search for answers on how to best attract and retain IT candidates. There are two separate groups of IT candidates investigated, IT students and IT professionals. Results show IT candidates form a homogeneous group. Outcomes display that IT candidates value the most flexibility in various forms. The most credited benefit is home office. Other valued benefits are sick days or even still meal vouchers. When it comes to decisions about new occupation, remuneration is the top factor IT candidates are interested in, followed by the actual job content, company culture and employer brand.

APA, Harvard, Vancouver, ISO, and other styles

45

Chen, Hsin-hua, and 陳信樺. "Strategic Management of Campaign Strategy：The Formulation, Implementation and Evaluation of A Legislator Candidate's Promotion Strategy." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/92794181672443066886.

Full text

Abstract:

碩士
世新大學
行政管理學研究所(含博、碩專班)
94
As for the abundance of the records and documents with reference to the research of Election in Taiwan, such as the United-election and the allotted-ballot, the combination between public opinion poll and the election, the image of candidates, the advertisements of elections, and so on; these methods and data ever are the strategies which is used in some elections by candidates without exception. Nevertheless, it is a key point in an election that how candidates manage various strategies within their elections ,however, we seldom observing the research which is emphasized from the point of view of analyses and discussions over managing all strategies of elections, alike how to make efficient use of “strategy management.” This thesis is based on three modes from strategy management to frame the analysis for the purpose to understand the process how to probe into a team-performance from the environment outside and inside, the establishment of strategies, the way to implement strategies, and the estimations of strategies of one candidate; one mode is organization concept approach of SWOT, another is the schemes of strategy management, and the other is the management of topics for discussion. From the angle of the author who joined in the headquarters of a electric campaign team, we can see the firsthand observation, deep-going interview and the way how to analyze the Media from media content, compare the second data of the outcome from the public opinion poll, and even more how to collect data for trying to explain and to analyze of the behaviors of the team to discuss the appropriation of practical use of strategy management. The research fond out that the electric team whom the author was observed lacked an efficient and steady mode to make strategic decisions, hence, there were many chaos and different ideas in the process of making strategic decisions. Furthermore, the research fond out that there were problems about the communication between the department of campaign material and the department of organization in the candidate’s group; and then the problems leaded to the delay of the execution of strategies. Notwithstanding, many candidates still won the elections finally because of their advantages about their professions, personal images, educational backgrounds, no matter from the public opinion polls or deep-going interviews both showed that it was due to the electric campaign team made broadly use of mass media to promote the fame instantly of the candidate, and the campaign material team emphasized on proper target to the specific people and electric campaign themes. In the end, according to the result of this thesis, strategy management could be use in the process of elections. However, it may have some appropriate adjustments which depend on every different electric organization, the situation which forms the strategy, and the role of the person who makes the strategy from the campaign main management of the cause with the variation of each campaign organization, its goals, schedules and the strategic effects what they expect in all aspects.

APA, Harvard, Vancouver, ISO, and other styles

46

Chu, Pei-chun, and 朱沛淳. "Crisis Communication Strategies of Political Candidates-A Case Study of 2005 Magistrate Election in Changhua." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/05975087167270947603.

Full text

Abstract:

碩士
大葉大學
人力資源暨公共關係學系
94
Literature of crisis communication strategies mainly were based on the approaches of case studies of content analysis, leading to simplified evaluations of the effects of strategies. This study, with the magistrate election of 2005 as its background, attempts to understand the crisis situation defined by candidates, the responsive strategies used to tackle the crisis, and the effects of the responsive strategies. A consequential mode of CRISIS SITUATION-STRATEGY-EFFECT was structured to examine homogeneous issue conflicts to achieve the purpose. In this study, CRISIS SITUATION was defined by Bradford and Garrett’s typology of crisis situations, STRATEGY by Benoit’s image repair theory, and EFFECT by Wu yi-jen’s definitions of media effect and social efficiency. A comprehensive evaluation of utilization of crisis communication strategies were anticipated through the efforts. Unlikely from the past literature, the study designed multi-ways to collect data, including content analysis, interviews and questionnaires, by which a comprehensive evaluation of crisis communication strategies used as well as the correlations among crisis situation, strategy and effects are anticipated. The results were as followed: 1.Denial and reducing offensiveness are the strategies most frequently used in the campaign. 2.The actual responsive strategy more in accorded with literature leads to more positive effect. 3.The use of crisis communication strategies should depend on other competitors’ follow-up reaction. 4.The electorate’s impression on certain candidate’s performance is correlated to the truth of competing accusations and the effects of strategy. 5.The electorate’s evaluation of the political party to which certain candidate belong is a potential resource of crisis beyond underestimation. 6.Agreement situation that Bradford and Garrett’s presented was seldom witnessed in this campaign.

APA, Harvard, Vancouver, ISO, and other styles

47

Jessica and 蕭伊君. "Image Restoration Strategies of Electoral Candidates-A Case Study of 2006 Mayor Election in Kaohsiung." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/15403955284929174510.

Full text

Abstract:

碩士
大葉大學
人力資源暨公共關係學系
95
This research is from a rhetorical prospective that is based on Bradford and Garrett’s “communication response model” (1995) and Benoit’s “image restoration strategies” (1997) as an analysis framework; it tests image restoration effects of candidates by using Coombs and Holladay’s (2002) A Situational Crisis Communication Theory(SCCT). Discuss the connections between crisis situations, strategies and effects on Huang and Chen, who are candidates of the Kaohsiung mayor election in 2006. The method of this research will introduce “Content analysis” and “Quantitative research” as a means to analyze emergency response strategies and image restoration effects on candidates Huang and Chen of the Kaohsiung mayor election. This includes: “Decreasing crisis assault” is a major response strategy of a candidate. Preference of voters on political groups will affect the image restoration effects on candidates. The past of candidates would greatly increase any image restoration effects in positive way. It may affect candidates negatively if voters are unimpressed during an urgent event, or emergency controlling ability, etc.

APA, Harvard, Vancouver, ISO, and other styles

48

INTINI, GIUSEPPE. "Innovative strategies to streamline continuous gravitational-wave candidates in the advanced LIGO-Virgo detector era." Doctoral thesis, 2020. http://hdl.handle.net/11573/1465051.

Full text

Abstract:

The goal of the LIGO-Virgo community is the gravitational-wave (GW) search and the consequent achievement of a deep knowledge of the universe. Although great results have been already obtained by detecting coalescing compact objects (such as binary Black Holes and even a Binary Neutron star), a lot of work remains still to be done, especially for what concerns Continuous GWs (CWs). Those signals, due to their long duration, have a central role in the study of the Universe, but are fainter than the signals we have detected so far. This Ph.D. thesis is focused on finding innovative strategies to improve CW searches in the advanced LIGO-Virgo detector era. The most accredited CW sources are non-axisymmetric rotating neutron stars. In general, there are four different approaches to study these signals: targeted, narrow band, directed and all-sky searches. The targeted search is a search where we assume to know all information on the source (sky position, spin frequency and its derivatives). The narrow band search widens the portion of frequency and its derivatives, working on an interval centered at the known information. The directed search considers stars whose sky position is known, but no information on the star spin frequency and derivatives is provided. In these cases, we can use a matched-filter technique. In fact, having at most two parameters to span, it is possible to perform a matched-filter search changing the parameters at a reasonable computational cost. In all-sky searches we are interested to look for CWs coming from unknown sources. In this case we cannot use the matched-filter technique due to the large size of the parameter space that must be spanned. Hence, we need to use hierarchical searches, such as the FrequencyHough algorithm, which is the core of this Ph.D. work. In the FrequencyHough search, the number of candidates obtained from the procedure is too high to be followed up, so it is necessary to rank them and deeply follow up only the most significant ones. However, it is not trivial to apply the procedure over a big portion of the frequencies we need to study as the computational cost grows linearly with frequency. Our goal is to identify CWs in the LIGO-Virgo data and estimate their parameters (sky position, frequency and first time derivative). For this purpose, we have analyzed candidates returned by the FrequencyHough pipeline to find a method to filter out the bulk of them. We have found out that any (injected) signal creates, besides a candidate with the parameters closest to those of the injected CW signal, a set of byproducts for which a small error in one of the parameters is compensated by small errors on the others according to some rules. Those byproducts have a detection statistic which tends to be higher than that for the background-noise candidates. Hence, the rules of error compensation create a correlation in the parameter space that links the sky position to the frequency and its time derivative.Once we identified those rules, and the patterns that they create, we have developed a veto procedure that uses those patterns to identify the presence of a CW signal. If we don’t have a pattern of candidates in the parameter space, it is unlikely that we will have a signal strong enough to be successfully detected in the follow up step. The innovative procedure we developed consists of computing two additional Hough transforms on the set of initial candidates, checking whether any correlation is present in the search parameter space and, alternatively, removing the candidates. The overall procedure removes about 50% of the false candidates (without excluding those related to the injected signals). Another aspect covered by the current Ph.D. thesis consists in trying to find alternative polarizations with respect to those that are foreseen by the General Relativity (GR). We have studied how deep potential nonGR components of GWs can be detected by the current 5vector targeted pipeline, and proposed an ad hoc solution for their detection with this pipeline.

APA, Harvard, Vancouver, ISO, and other styles

49

Giammo, Joseph Donald. "Polls and voting behavior: the impact of polling information on candidate preference, turnout, and strategic voting." Thesis, 2004. http://hdl.handle.net/2152/1194.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Giammo, Joseph Donald Shaw Daron R. "Polls and voting behavior the impact of polling information on candidate preference, turnout, and strategic voting /." 2004. http://wwwlib.umi.com/cr/utexas/fullcit?p3142725.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic 'Strategic candidates'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles