Journal articles on the topic 'STING Knockout'
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Kato, Yasuhiro, JeongHoon Park, Hyota Takamatsu, Hachirou Konaka, Wataru Aoki, Syunsuke Aburaya, Mitsuyoshi Ueda, et al. "Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus." Annals of the Rheumatic Diseases 77, no. 10 (June 26, 2018): 1507–15. http://dx.doi.org/10.1136/annrheumdis-2018-212988.
Full textSellaththurai, Sarithaa, Sumi Jung, Myoung-Jin Kim, Kishanthini Nadarajapillai, Subothini Ganeshalingam, Joon Bum Jeong, and Jehee Lee. "CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection." Biomolecules 13, no. 2 (February 8, 2023): 324. http://dx.doi.org/10.3390/biom13020324.
Full textFroechlich, Guendalina, Carmen Caiazza, Chiara Gentile, Anna Morena D’Alise, Maria De Lucia, Francesca Langone, Guido Leoni, et al. "Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of Herpes Simplex Oncolytic Virus." Cancers 12, no. 11 (November 17, 2020): 3407. http://dx.doi.org/10.3390/cancers12113407.
Full textSun, Shaohua, Yulin Xu, Ming Qiu, Sen Jiang, Qi Cao, Jia Luo, Tangjie Zhang, et al. "Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner." Viruses 15, no. 3 (February 28, 2023): 646. http://dx.doi.org/10.3390/v15030646.
Full textAnghelina, Daniela, Eric Lam, and Erik Falck-Pedersen. "Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity." Journal of Virology 90, no. 13 (April 13, 2016): 5915–27. http://dx.doi.org/10.1128/jvi.00500-16.
Full textAoki, Masaya, Licun Wu, Junichi Murakami, Yidan Zhao, Hana Yun, and Marc de Perrot. "IRF3 Knockout Results in Partial or Complete Rejection of Murine Mesothelioma." Journal of Clinical Medicine 10, no. 21 (November 7, 2021): 5196. http://dx.doi.org/10.3390/jcm10215196.
Full textXu, Yulin, Youwen Zhang, Shaohua Sun, Jia Luo, Sen Jiang, Jiajia Zhang, Xueliang Liu, et al. "The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function." Viruses 13, no. 9 (September 14, 2021): 1829. http://dx.doi.org/10.3390/v13091829.
Full textLangereis, Martijn A., Huib H. Rabouw, Melle Holwerda, Linda J. Visser, and Frank J. M. van Kuppeveld. "Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells." Journal of Virology 89, no. 21 (August 26, 2015): 11169–73. http://dx.doi.org/10.1128/jvi.01781-15.
Full textLi, Suxin, Jian Wang, Jonathan Wilhelm, Qingtai Su, Gaurav Bharadwaj, Jason Miller, Wei Li, et al. "Abstract 4234: ONM-501: A polyvalent STING agonist for oncology immunotherapy." Cancer Research 82, no. 12_Supplement (June 15, 2022): 4234. http://dx.doi.org/10.1158/1538-7445.am2022-4234.
Full textNeupane, Chiranjivi, Ramesh Sharma, Hyun Jin Shin, Su Eun Park, and Jin Bong Park. "Alteration of GABA transporter impairs cognitive behavior in Sting knockout mice." IBRO Reports 6 (September 2019): S434. http://dx.doi.org/10.1016/j.ibror.2019.07.1379.
Full textLi, Yang, Sharmy J. James, David H. Wyllie, Claire Wynne, Agnes Czibula, Ahmed Bukhari, Katherine Pye, et al. "TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages." Proceedings of the National Academy of Sciences 116, no. 33 (July 25, 2019): 16479–88. http://dx.doi.org/10.1073/pnas.1901090116.
Full textPapinska, Joanna, Harini Bagavant, Grzegorz B. Gmyrek, and Umesh S. Deshmukh. "Pulmonary Involvement in a Mouse Model of Sjögren’s Syndrome Induced by STING Activation." International Journal of Molecular Sciences 21, no. 12 (June 25, 2020): 4512. http://dx.doi.org/10.3390/ijms21124512.
Full textBai, Juli, Christopher Cervantes, Juan Liu, Sijia He, Haiyan Zhou, Bilin Zhang, Huan Cai, et al. "DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway." Proceedings of the National Academy of Sciences 114, no. 46 (October 30, 2017): 12196–201. http://dx.doi.org/10.1073/pnas.1708744114.
Full textLiu, Yonghong, Yuanyuan Liu, Jiaming Wu, Bernard Roizman, and Grace Guoying Zhou. "Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection." Proceedings of the National Academy of Sciences 115, no. 14 (March 20, 2018): E3230—E3237. http://dx.doi.org/10.1073/pnas.1720464115.
Full textZhao, Qinglan, Murli Manohar, Yi Wei, Stephen J. Pandol, and Aida Habtezion. "STING signalling protects against chronic pancreatitis by modulating Th17 response." Gut 68, no. 10 (January 31, 2019): 1827–37. http://dx.doi.org/10.1136/gutjnl-2018-317098.
Full textDing, Qiang, Jenna M. Gaska, Florian Douam, Lei Wei, David Kim, Metodi Balev, Brigitte Heller, and Alexander Ploss. "Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease." Proceedings of the National Academy of Sciences 115, no. 27 (June 18, 2018): E6310—E6318. http://dx.doi.org/10.1073/pnas.1803406115.
Full textPawaria, Sudesh, and Ann Marshak-Rothstein. "Endosomal RNA-sensing toll-like receptor stimulated T cells play a unique role in autoimmune manifestations in murine model of DNA accrual." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 75.9. http://dx.doi.org/10.4049/jimmunol.198.supp.75.9.
Full textCetinbas, Naniye Malli, Travis Monnell, Winnie Lee, Kalli Catcott, Chen-Ni Chin, Pamela Shaw, Kelly Slocum, et al. "620 Tumor cell-intrinsic STING pathway is activated in the presence of cues from immune cells and contributes to the anti-tumor activity of tumor cell-targeted STING agonist antibody-drug conjugates." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A656. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0620.
Full textLei, Zhao, Meihong Deng, Zhongjie Yi, Qian Sun, Richard A. Shapiro, Hongbo Xu, Tunliang Li, et al. "cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING." American Journal of Physiology-Gastrointestinal and Liver Physiology 314, no. 6 (June 1, 2018): G655—G667. http://dx.doi.org/10.1152/ajpgi.00326.2017.
Full textNi, Huanhe, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, et al. "T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer." Journal for ImmunoTherapy of Cancer 10, no. 9 (September 2022): e005151. http://dx.doi.org/10.1136/jitc-2022-005151.
Full textLee, Hailey R., Evan R. Abt, Khalid Rashid, Amanda L. Creech, Keke Liang, Liu Wei, Arthur Cho, et al. "Abstract 2483: Detection of STING-induced immune activation via [18F]FDG-PET imaging." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2483. http://dx.doi.org/10.1158/1538-7445.am2022-2483.
Full textGhosh, Arundhati, Lulu Shao, Padmavati Sampath, Nidhi Patel, Jianzhong Zhu, Viet Hornung, Stephen Thorne, and Saumendra N. Sarkar. "2′-5′ Oligoadenylate like (OASL) inhibits interferon induction by inhibiting cGAS activity during DNA virus infection." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 129.9. http://dx.doi.org/10.4049/jimmunol.198.supp.129.9.
Full textYoung, Elizabeth "Betsy", Courtney R. Schott, and E. Alejandro Sweet-Cordero. "Abstract A005: STING activation overcomes immune escape in osteosarcoma metastasis." Clinical Cancer Research 28, no. 18_Supplement (September 15, 2022): A005. http://dx.doi.org/10.1158/1557-3265.sarcomas22-a005.
Full textYoung, Elizabeth P., Courtney R. Schott, Amanda Koehne, Christine Johnson, and E. Alejandro Sweet-Cordero. "Abstract A51: STING activation overcomes immune escape in osteosarcoma metastasis." Cancer Immunology Research 10, no. 12_Supplement (December 1, 2022): A51. http://dx.doi.org/10.1158/2326-6074.tumimm22-a51.
Full textSchwertner, Barbara, Georg Lindner, Camila Toledo Toledo Stauner, Elisa Klapproth, Clara Magnus, Anette Rohrhofer, Stefanie Gross, et al. "Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo." Cancers 13, no. 12 (June 19, 2021): 3058. http://dx.doi.org/10.3390/cancers13123058.
Full textDang, Sheng, Wanyang Li, Shubo Wen, Yang Song, Meirong Bai, Shuyan Li, Zeliang Chen, and Jingbo Zhai. "Ag85a-S2 Activates cGAS-STING Signaling Pathway in Intestinal Mucosal Cells." Vaccines 10, no. 12 (December 16, 2022): 2170. http://dx.doi.org/10.3390/vaccines10122170.
Full textKelleher, Alan, Yin Wang, Luke Broses, Yu Leo Lei, and Phillip Palmbos. "Abstract A27: TRIM29-mediated immune evasion in bladder cancer invasive progression." Cancer Immunology Research 10, no. 12_Supplement (December 1, 2022): A27. http://dx.doi.org/10.1158/2326-6074.tumimm22-a27.
Full textBai, Lu, Jing Dai, Yuxuan Xia, Kaichuan He, Hongmei Xue, Qi Guo, Danyang Tian, et al. "Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway." Oxidative Medicine and Cellular Longevity 2022 (July 22, 2022): 1–12. http://dx.doi.org/10.1155/2022/1392896.
Full textLiang, Yaoji, Suqin Wu, and Jiahuai Han. "RIP3 is involved in host defense against HSV-1 infection via enhancing STING mediated antiviral signaling (P1405)." Journal of Immunology 190, no. 1_Supplement (May 1, 2013): 57.14. http://dx.doi.org/10.4049/jimmunol.190.supp.57.14.
Full textHasan, Maroof, Vijay K. Gonugunta, Nicole Dobbs, Aktar Ali, Guillermo Palchik, Maria A. Calvaruso, Ralph J. DeBerardinis, and Nan Yan. "Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism." Proceedings of the National Academy of Sciences 114, no. 4 (January 9, 2017): 746–51. http://dx.doi.org/10.1073/pnas.1611113114.
Full textAvery, Joseph, Chi Ma, FuKun Hoffmann, and Peter Hoffmann. "Selenoprotein I is important for phosphatidylethanolamine synthesis and autophagy during T cell activation." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 150.8. http://dx.doi.org/10.4049/jimmunol.204.supp.150.8.
Full textGao, Daxing, Jiaxi Wu, You-Tong Wu, Fenghe Du, Chukwuemika Aroh, Nan Yan, Lijun Sun, and Zhijian J. Chen. "Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses." Science 341, no. 6148 (August 8, 2013): 903–6. http://dx.doi.org/10.1126/science.1240933.
Full textGusho, Elona, and Laimonis A. Laimins. "Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS." PLOS Pathogens 18, no. 7 (July 25, 2022): e1010725. http://dx.doi.org/10.1371/journal.ppat.1010725.
Full textBayer, Abraham L., Jodie Pietruska, Jaymes Farrell, Siobhan McRee, Pilar Alcaide, and Philip W. Hinds. "AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma." Cancers 14, no. 3 (January 23, 2022): 572. http://dx.doi.org/10.3390/cancers14030572.
Full textGhosh, Arundhati, Padmavathi Sampath, Jianzhong Zhu, Veit Hornung, Stephen Thorne, and Saumendra N. Sarkar. "Modulation of cellular immune response by 2′-5′ Oligoadenylate Synthetase - like (OASL) proteins during DNA virus infection." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 61.6. http://dx.doi.org/10.4049/jimmunol.196.supp.61.6.
Full textGong, Yan, Guangwei Li, Jun Tao, Ne N. Wu, Machender R. Kandadi, Yaguang Bi, Shuyi Wang, Zhaohui Pei, and Jun Ren. "Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866, no. 10 (October 2020): 165855. http://dx.doi.org/10.1016/j.bbadis.2020.165855.
Full textJiang, Xiaoyi, Jian Wang, Xichen Zheng, Zhida Liu, Xinyu Zhang, Yuwei Li, Jonathan Wilhelm, et al. "Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy." Journal for ImmunoTherapy of Cancer 10, no. 5 (May 2022): e003960. http://dx.doi.org/10.1136/jitc-2021-003960.
Full textWang, Dang, Ruixue Wang, and Kui Li. "Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells." Viruses 14, no. 1 (January 5, 2022): 89. http://dx.doi.org/10.3390/v14010089.
Full textMathsyaraja, Haritha, Benjamin Wolf, Chari Cortez, Adam Kashishian, Alison Karst, Madelyn Cueva, Min Wang, Kathleen S. Keegan, and Jennifer Cain. "Abstract 2079: Tumor cell intrinsic inactivation of TREX1 increases type I IFN signaling and immune cell recruitment." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2079. http://dx.doi.org/10.1158/1538-7445.am2022-2079.
Full textLiu, Shuaitong, Gregory Mazo, Tuo Zhang, Ning Yang, Yi Wang, Adrian Tan, Jiahu Wang, et al. "696 Single-cell RNA-seq reveals the critical roles of the STING- and MDA5-mediated cytosolic nucleic acid-sensing pathways as well as IFNAR/STAT2 signaling in recombinant MVA-induced antitumor immunity." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A724. http://dx.doi.org/10.1136/jitc-2021-sitc2021.696.
Full textTemple, Rachel Mary, Eyal Amiel, and Joshua J. Obar. "When signals get crossed: the consequences of dual allergen- and influenza-mediated signaling in mast cells." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 123.4. http://dx.doi.org/10.4049/jimmunol.196.supp.123.4.
Full textNemazee, David, Linghang Peng, Tanya Blane, Deli Huang, and Amanda Gavin. "Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors, including endolysosomal TLRs and a STING dependent sensing pathway." Journal of Immunology 208, no. 1_Supplement (May 1, 2022): 158.05. http://dx.doi.org/10.4049/jimmunol.208.supp.158.05.
Full textKazmierski, Julia, Carina Elsner, Katinka Döhner, Shuting Xu, Aurélie Ducroux, Fabian Pott, Jenny Jansen, et al. "A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913." Journal of Immunology 209, no. 3 (August 1, 2022): 535–47. http://dx.doi.org/10.4049/jimmunol.2100685.
Full textGhonim, Mohamed A., Salome V. Ibba, Abdelmetalab F. Tarhuni, Youssef Errami, Hanh H. Luu, Matthew J. Dean, Ali H. El-Bahrawy, et al. "Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer." Journal for ImmunoTherapy of Cancer 9, no. 1 (January 2021): e001643. http://dx.doi.org/10.1136/jitc-2020-001643.
Full textDean, Matthew J., Liqin Zheng, Phaethon Philbrook, Augusto C. Ochoa, and A. Hamid Boulares. "Abstract 2081: Poly ADP-ribose polymerase inhibition enhances T cell cytotoxicity and anti-tumor function by altering NAD+ levels." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2081. http://dx.doi.org/10.1158/1538-7445.am2022-2081.
Full textLi, Jian, Josephine Mun-Yee Ko, Wei Dai, Valen Zhuoyou Yu, Hoi Yan Ng, Jean-Sébastien Hoffmann, and Maria Li Lung. "Depletion of DNA Polymerase Theta Inhibits Tumor Growth and Promotes Genome Instability through the cGAS-STING-ISG Pathway in Esophageal Squamous Cell Carcinoma." Cancers 13, no. 13 (June 26, 2021): 3204. http://dx.doi.org/10.3390/cancers13133204.
Full textHaarer, Elena L., Corey J. Theodore, Shirley Guo, Ryan B. Frier, and Kenneth G. Campellone. "Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence." PLOS Genetics 19, no. 1 (January 27, 2023): e1010045. http://dx.doi.org/10.1371/journal.pgen.1010045.
Full textLi, Xuefeng, Kristin Huntoon, Yifan Wang, Carl Walkey, Betty Y. Kim, and Wen Jiang. "Abstract 2067: NL-201, a de novo engineered IL2/IL15 mimic, synergizes with radiation to generate potent antitumor immunity." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2067. http://dx.doi.org/10.1158/1538-7445.am2022-2067.
Full textLejeune, Pascale, Véronique Cruciani, Axel Berg-Larsen, Andreas Schlicker, Anne Mobergslien, Lisa Bartnitzky, Sandra Berndt, et al. "Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy." Journal for ImmunoTherapy of Cancer 9, no. 10 (October 2021): e002387. http://dx.doi.org/10.1136/jitc-2021-002387.
Full textLoew, Lisa, Niluka Goonawardane, Jeremy Ratcliff, Dung Nguyen, and Peter Simmonds. "Use of a small DNA virus model to investigate mechanisms of CpG dinucleotide-induced attenuation of virus replication." Journal of General Virology 101, no. 11 (November 1, 2020): 1202–18. http://dx.doi.org/10.1099/jgv.0.001477.
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