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Journal articles on the topic 'Stimulus responsive hydrogel'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Lin, Deqing, Lei Lei, Shuai Shi, and Xingyi Li. "Stimulus‐Responsive Hydrogel for Ophthalmic Drug Delivery." Macromolecular Bioscience 19, no. 6 (April 26, 2019): 1900001. http://dx.doi.org/10.1002/mabi.201900001.

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2

SUZUKI, Daisuke. "Preparation of Anisotropic Stimulus-Responsive Hydrogel Microspheres." Hosokawa Powder Technology Foundation ANNUAL REPORT 26 (2018): 85–88. http://dx.doi.org/10.14356/hptf.16112.

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3

Biswas, Subharanjan, Lakshmi Priya Datta, and Soumyajit Roy. "A Stimuli-Responsive Supramolecular Hydrogel for Controlled Release of Drug." Journal of Molecular and Engineering Materials 05, no. 03 (September 2017): 1750011. http://dx.doi.org/10.1142/s2251237317500113.

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An inexpensive, facile, and environmentally benign method has been developed for the preparation of stimuli-responsive and self-healing polyacrylic acid–chitosan-based supramolecular hydrogels. Guanidine hydrochloride is used as the supramolecular crosslinker to form an interconnected network with polyacrylic acid–chitosan complex. Because of the dynamic equilibrium between the hydrogen-bonding sites of the components, the hydrogels were found to be self-healable and sensitive to biochemical-stimulus, such as pH. Controlled loading of drug like doxorubicin and its significant anticancer activity of such hydrogels is worth mentioning.

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4

Jaggers, Ross W., and Stefan A. F. Bon. "Independent responsive behaviour and communication in hydrogel objects." Materials Horizons 4, no. 3 (2017): 402–7. http://dx.doi.org/10.1039/c7mh00033b.

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We show the fabrication of autonomous soft hydrogel alginate-based objects, namely fibres and beads. They have an individually programmed time delay in their response to a shared environmental stimulus and the ability to communicate when in close proximity to one another.

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5

Zhao, Haifeng, Heng An, Baozhong Xi, Yan Yang, Jianglei Qin, Yong Wang, Yingna He, and Xinguo Wang. "Self-Healing Hydrogels with both LCST and UCST through Cross-Linking Induced Thermo-Response." Polymers 11, no. 3 (March 13, 2019): 490. http://dx.doi.org/10.3390/polym11030490.

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Self-healing hydrogels have drawngreat attention in the past decade since the self-healing property is one of the characteristics of living creatures. In this study, poly(acrylamide-stat-diacetone acrylamide) P(AM-stat-DAA) with a pendant ketone group was synthesized from easy accessible monomers, and thermo-responsive self-healing hydrogels were prepared through a series of diacylhydrazide compounds cross-linking without any additional stimulus. Although the copolymers do not show thermo-response, the hydrogels became thermo-responsive andboth the lower critical solution temperature (LCST) and upper critical solution temperature (UCST) varied with the composition of the copolymer and structure of cross-linkers. With a dynamic covalent bond connection, the hydrogel showed gel-sol-gel transition triggered by acidity, redox, and ketone to acylhydrazide group ratios. This is another interesting cross-linking induced thermo-responsive (CIT) hydrogel with different properties compared to PNIPAM-based thermo-responsive hydrogels. The self-healing hydrogel with CIT properties could have great potential for application in areas related to bioscience, life simulation, and temperature switching.

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6

Shi, Xiangning, Yudong Zheng, Guojie Wang, Qinghua Lin, and Jinsheng Fan. "pH- and electro-response characteristics of bacterial cellulose nanofiber/sodium alginate hybrid hydrogels for dual controlled drug delivery." RSC Adv. 4, no. 87 (2014): 47056–65. http://dx.doi.org/10.1039/c4ra09640a.

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An ionic crosslinking nanocellulose/sodium alginate (BC/SA) hybrid hydrogel was prepared as a dual-stimuli responsive release system. The drug release rate of BC/SA hybrid hydrogels in vitro not only depend on pH value but also depend on the presence of electric stimulus.

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7

Xiong, Yuan, Kun Yan, William E. Bentley, Hongbing Deng, Yumin Du, Gregory F. Payne, and Xiao-Wen Shi. "Compartmentalized Multilayer Hydrogel Formation Using a Stimulus-Responsive Self-Assembling Polysaccharide." ACS Applied Materials & Interfaces 6, no. 4 (February 7, 2014): 2948–57. http://dx.doi.org/10.1021/am405544r.

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8

Goessl, Andreas, Nicola Tirelli, and Jeffrey A. Hubbell. "A hydrogel system for stimulus-responsive, oxygen-sensitive in situ gelation." Journal of Biomaterials Science, Polymer Edition 15, no. 7 (January 2004): 895–904. http://dx.doi.org/10.1163/1568562041271039.

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9

Geraths, Christian, Laura Eichstädter, Raphael J. Gübeli, Erik H. Christen, Christian Friedrich, and Wilfried Weber. "Synthesis and characterization of a stimulus-responsive l-ornithine-degrading hydrogel." Journal of Controlled Release 165, no. 1 (January 2013): 38–43. http://dx.doi.org/10.1016/j.jconrel.2012.10.022.

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10

Guo, J., H. Sun, W. Lei, Y. Tang, S. Hong, H. Yang, F. R. Tay, and C. Huang. "MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery." Journal of Dental Research 98, no. 5 (March 15, 2019): 564–71. http://dx.doi.org/10.1177/0022034519831931.

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Currently available drug delivery systems for oral diseases suffer from short retention time and poor local concentrations at the target site. A biodegradable stimulus-responsive hydrogel was synthesized in the present study to evaluate its application as an environmentally sensitive carrier for on-demand intraoral drug delivery. The hydrogel was synthesized from diacrylate-containing polyethylene glycol–based scaffolds and a cysteine-terminated peptide crosslinker (CGPQG↓IWGQC) via a Michael-type addition reaction. Because CGPQG↓IWGQC can be cleaved by matrix metalloproteinase 8 (MMP-8), minocycline hydrochloride, bovine serum albumin, or an antibacterial peptide (KSL) was incorporated into the scaffolds to evaluate the MMP-8-responsive release behavior of the on-demand drug delivery system. Hydrogel characterization and gelation kinetics were examined with gel time, Fourier-transform infrared spectroscopy, scanning electron microscopy, and measurements of rheologic parameters. Degradation behavior and MMP-8-responsive drug release were performed by high-performance liquid chromatography and protein-specific assay. Biocompatibility evaluation indicated that the hydrogels were noncytotoxic. Antibacterial testing demonstrated that the released drugs were able to maintain bioactivity. Taken together, these results suggest that the MMP-8-sensitive hydrogel is a promising candidate for on-demand intraoral localized drug delivery. Because MMP-8 is one of the most important biomarkers for periodontitis, the MMP-8-responsive hydrogel has potential to be used for in situ adaptive degradation in response to chronic periodontitis and peri-implantitis. This notion has to be tested in animal models of periodontal disease.

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11

Tang, Linya, Lanfang Wen, Shouping Xu, Pihui Pi, and Xiufang Wen. "Ca2+, redox, and thermoresponsive supramolecular hydrogel with programmed quadruple shape memory effect." Chemical Communications 54, no. 58 (2018): 8084–87. http://dx.doi.org/10.1039/c8cc03304h.

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12

Bae, Jinhye, Nakul P. Bende, Arthur A. Evans, Jun-Hee Na, Christian D. Santangelo, and Ryan C. Hayward. "Programmable and reversible assembly of soft capillary multipoles." Materials Horizons 4, no. 2 (2017): 228–35. http://dx.doi.org/10.1039/c6mh00531d.

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13

ter Schiphorst, J., M. van den Broek, T. de Koning, J. N. Murphy, A. P. H. J. Schenning, and A. C. C. Esteves. "Dual light and temperature responsive cotton fabric functionalized with a surface-grafted spiropyran–NIPAAm-hydrogel." Journal of Materials Chemistry A 4, no. 22 (2016): 8676–81. http://dx.doi.org/10.1039/c6ta00161k.

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14

He, Xiaomin, Yan Sun, Jiahui Wu, Yang Wang, Feng Chen, Ping Fan, Mingqiang Zhong, et al. "Dual-stimulus bilayer hydrogel actuators with rapid, reversible, bidirectional bending behaviors." Journal of Materials Chemistry C 7, no. 17 (2019): 4970–80. http://dx.doi.org/10.1039/c9tc00180h.

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15

Sugiura, Takumi, Takurou Kanada, Daisuke Mori, Hiroyuki Sakai, Aya Shibata, Yoshiaki Kitamura, and Masato Ikeda. "Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative." Soft Matter 16, no. 4 (2020): 899–906. http://dx.doi.org/10.1039/c9sm01969c.

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16

Kim, Yuna, Jaekwang Song, Seong Chae Park, Minchul Ahn, Myung Jin Park, Sung Hyuk Song, Si-Youl Yoo, Seung Gweon Hong, and Byung Hee Hong. "Photoinitiated Polymerization of Hydrogels by Graphene Quantum Dots." Nanomaterials 11, no. 9 (August 25, 2021): 2169. http://dx.doi.org/10.3390/nano11092169.

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As a smart stimulus-responsive material, hydrogel has been investigated extensively in many research fields. However, its mechanical brittleness and low strength have mattered, and conventional photoinitiators used during the polymerization steps exhibit high toxicity, which limits the use of hydrogels in the field of biomedical applications. Here, we address the dual functions of graphene quantum dots (GQDs), one to trigger the synthesis of hydrogel as photoinitiators and the other to improve the mechanical strength of the as-synthesized hydrogel. GQDs embedded in the network effectively generated radicals when exposed to sunlight, leading to the initiation of polymerization, and also played a significant role in improving the mechanical strength of the crosslinked chains. Thus, we expect that the resulting hydrogel incorporated with GQDs would enable a wide range of applications that require biocompatibility as well as higher mechanical strength, including novel hydrogel contact lenses and bioscaffolds for tissue engineering.

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17

Kishore, Pabbisetti Vayu Nandana, Sai Shankar Madhuvarasu, and Satyanarayana Moru. "Stimulus responsive hydrogel-coated etched fiber Bragg grating for carcinogenic chromium (VI) sensing." Optical Engineering 57, no. 01 (January 2, 2018): 1. http://dx.doi.org/10.1117/1.oe.57.1.017101.

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18

Kabiri, Maryam, Syed H. Kamal, Sandip V. Pawar, Protiva R. Roy, Maziar Derakhshandeh, Ujendra Kumar, Savvas G. Hatzikiriakos, Sazzad Hossain, and Vikramaditya G. Yadav. "A stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for ocular drug delivery." Drug Delivery and Translational Research 8, no. 3 (March 5, 2018): 484–95. http://dx.doi.org/10.1007/s13346-018-0504-x.

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19

Thompson, Benjamin R., Marius Rutkevičius, Tommy S. Horozov, Simeon D. Stoyanov, and Vesselin N. Paunov. "Smart soaps: stimulus responsive soap–hydrogel bead composites for controlled dissolution and release of actives." Materials Chemistry Frontiers 2, no. 2 (2018): 402–9. http://dx.doi.org/10.1039/c7qm00556c.

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20

Simon, Anna J., Luke T. Walls-Smith, and Kevin W. Plaxco. "Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel." Analyst 143, no. 11 (2018): 2531–38. http://dx.doi.org/10.1039/c8an00337h.

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The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink stability and response properties.

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21

Mao, Xiaoxia, Dongsheng Mao, Juanjuan Jiang, Benyue Su, Guifang Chen, and Xiaoli Zhu. "A semi-dry chemistry hydrogel-based smart biosensing platform for on-site detection of metal ions." Lab on a Chip 21, no. 1 (2021): 154–62. http://dx.doi.org/10.1039/d0lc00855a.

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A semi-dry chemistry-based biosensing platform was developed for detection of metal ions by intelligent stimulus-responsive DNA hydrogel. The platform combines the advantages of liquid (wet) chemistry and solid (dry) chemistry, providing a promising approach for on-site testing.

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22

Ng, T. Y., Hua Li, Y. K. Yew, and K. Y. Lam. "Effects of Initial-Fixed Charge Density on pH-Sensitive Hydrogels Subjected to Coupled pH and Electric Field Stimuli: A Meshless Analysis." Journal of Biomechanical Engineering 129, no. 2 (September 4, 2006): 148–55. http://dx.doi.org/10.1115/1.2472370.

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In this paper, we study the effects of initial fixed-charge density on the response behavior of pH-sensitive hydrogels subjected to coupled stimuli, namely, solution pH and externally applied electric field. This is the first instance in which a coupled stimuli numerical analysis has been carried out for these polymer gels, which are used as active sensing/actuating elements in advanced biomicroelectromechanical systems devices. In this work, a chemo-electro-mechanical formulation, termed the multi-effect-coupling pH-stimulus (MECpH) model, is first presented. This mathematical model takes into account the ionic species diffusion, electric potential coupling, and large mechanical deformation. In addition, a correlation between the diffusive hydrogen ions and fixed-charge groups on the hydrogel polymeric chains is established based on the Langmuir absorption isotherm, and incorporated accordingly into the MECpH model. To solve the resulting highly nonlinear and highly coupled partial differential equations of this mathematical model, the Hermite-Cloud method, a novel true meshless technique, is employed. To demonstrate the accuracy and robustness the MECpH model, computed numerical results are compared with experimental data available from literature. Following this validation, several numerical studies are carried out to investigate the effects of initial fixed-charge density on the volumetric variations of these pH-stimulus-responsive hydrogels when immersed in buffered solutions.

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23

Alruwaili, Nabil K., Ameeduzzafar Zafar, Syed Sarim Imam, Khalid Saad Alharbi, Nasser Hadal Alotaibi, Sultan Alshehri, Nabil A. Alhakamy, Abdulaziz I. Alzarea, Muhammad Afzal, and Mohammed Elmowafy. "Stimulus Responsive Ocular Gentamycin-Ferrying Chitosan Nanoparticles Hydrogel: Formulation Optimization, Ocular Safety and Antibacterial Assessment." International Journal of Nanomedicine Volume 15 (June 2020): 4717–37. http://dx.doi.org/10.2147/ijn.s254763.

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24

Francone, Achille, Timothy Kehoe, Isabel Obieta, Virginia Saez-Martinez, Leire Bilbao, Ali Khokhar, Nikolaj Gadegaard, Claudia Simao, Nikolaos Kehagias, and Clivia Sotomayor Torres. "Integrated 3D Hydrogel Waveguide Out-Coupler by Step-and-Repeat Thermal Nanoimprint Lithography: A Promising Sensor Device for Water and pH." Sensors 18, no. 10 (September 26, 2018): 3240. http://dx.doi.org/10.3390/s18103240.

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Hydrogel materials offer many advantages for chemical and biological sensoring due to their response to a small change in their environment with a related change in volume. Several designs have been outlined in the literature in the specific field of hydrogel-based optical sensors, reporting a large number of steps for their fabrication. In this work we present a three-dimensional, hydrogel-based sensor the structure of which is fabricated in a single step using thermal nanoimprint lithography. The sensor is based on a waveguide with a grating readout section. A specific hydrogel formulation, based on a combination of PEGDMA (Poly(Ethylene Glycol DiMethAcrylate)), NIPAAm (N-IsoPropylAcrylAmide), and AA (Acrylic Acid), was developed. This stimulus-responsive hydrogel is sensitive to pH and to water. Moreover, the hydrogel has been modified to be suitable for fabrication by thermal nanoimprint lithography. Once stimulated, the hydrogel-based sensor changes its topography, which is characterised physically by AFM and SEM, and optically using a specific optical set-up.

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25

Liu, Qimin, Muyu Liu, and Hua Li. "A transient simulation to predict the kinetic behavior of magnetic-sensitive hydrogel responsive to magnetic stimulus." International Journal of Mechanical Sciences 182 (September 2020): 105765. http://dx.doi.org/10.1016/j.ijmecsci.2020.105765.

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26

Witika, Bwalya A., Jessé-Clint Stander, Vincent J. Smith, and Roderick B. Walker. "Nano Co-Crystal Embedded Stimuli-Responsive Hydrogels: A Potential Approach to Treat HIV/AIDS." Pharmaceutics 13, no. 2 (January 20, 2021): 127. http://dx.doi.org/10.3390/pharmaceutics13020127.

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Currently, the human immunodeficiency virus (HIV) that causes acquired immunodeficiency syndrome (AIDS) can only be treated successfully, using combination antiretroviral (ARV) therapy. Lamivudine (3TC) and zidovudine (AZT), two compounds used for the treatment of HIV and prevention of disease progression to AIDS are used in such combinations. Successful therapy with 3TC and AZT requires frequent dosing that may lead to reduced adherence, resistance and consequently treatment failure. Improved toxicity profiles of 3TC and AZT were observed when combined as a nano co-crystal (NCC). The use of stimuli-responsive delivery systems provides an opportunity to overcome the challenge of frequent dosing, by controlling and/or sustaining delivery of drugs. Preliminary studies undertaken to identify a suitable composition for a stimulus-responsive in situ forming hydrogel carrier for 3TC-AZT NCC were conducted, and the gelation and erosion time were determined. A 25% w/w Pluronic® F-127 thermoresponsive hydrogel was identified as a suitable carrier as it exhibited a gelation time of 5 min and an erosion time of 7 days. NCC-loaded hydrogels were evaluated using in vitro dissolution and cytotoxicity assays. In vitro dissolution undertaken using membrane-less diffusion over 168 h revealed that 3TC and AZT release from NCC-loaded hydrogels was complete and followed zero-order kinetic processes, whereas those loaded with the micro co-crystal and physical mixture were incomplete and best described using the Korsmeyer–Peppas kinetic model. The release of AZT and 3TC from the physical mixture and MCC-loaded gel exhibited a value for n of 0.595 for AZT release from the physical mixture and 0.540 for the MCC technology, whereas the release exponent for 3TC was 0.513 for the physical mixture and 0.557 for the MCC technology indicating that diffusion and erosion controlled 3TC and AZT release. In vitro cytotoxicity assay data revealed that the addition of NCC to the thermoresponsive hydrogel resulted in an improved cell viability of 88.0% ± 5.0% when compared to the cell viability of the NCC of 76.9% ± 5.0%. The results suggest that the use of a thermoresponsive nanosuspension may have the potential to be delivered as an intramuscular injection that can subsequently increase bioavailability and permit dose reduction and/or permit use of a longer dosing frequency.

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Xu, Zhangpeng, Erni Tang, and Huijing Zhao. "An Environmentally Sensitive Silk Fibroin/Chitosan Hydrogel and Its Drug Release Behaviors." Polymers 11, no. 12 (December 1, 2019): 1980. http://dx.doi.org/10.3390/polym11121980.

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To fabricate environmentally sensitive hydrogels with better biocompatibility, natural materials such as protein and polysaccharide have been widely used. Environmentally sensitive hydrogels can be used as a drug carrier for sustained drug release due to its stimulus responsive performance. The relationship between the internal structure of hydrogels and their drug delivery behaviors remains indeterminate. In this study, environmentally sensitive hydrogels fabricated by blending silk fibroin/chitosan with different mass ratios were successfully prepared using 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (EDC)/N-Hydroxysuccinimide (NHS) cross-linking agent. Scanning-electron microscopy (SEM) images showed the microcosmic surface of the gel had a 3-D network-like and interconnected pore structure. The N2 adsorption–desorption method disclosed the existence of macroporous and mesoporous structures in the internal structure of hydrogels. Data of compression tests showed its good mechanical performance. The swelling performance of hydrogels exhibited stimuli responsiveness at different pH and ion concentration. With the increase of pH and ion concentration, the swelling ratios of hydrogels (silk fibroin (SF)/ chitosan (CS) = 8/2 and 7/3) decreased. Methylene blue (MB) was loaded into the hydrogels to confirm the potential of sustained drug release and pH-responsive behavior. Therefore, due to the porous structure, stable mechanical strength, stimuli responsive swelling performance, and drug release behaviors, the SF/CS composite hydrogels have potential applications in controlled drug release.

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Bouzin, Margaux, Amirbahador Zeynali, Mario Marini, Laura Sironi, Riccardo Scodellaro, Laura D’Alfonso, Maddalena Collini, and Giuseppe Chirico. "Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials." Sensors 21, no. 17 (September 1, 2021): 5891. http://dx.doi.org/10.3390/s21175891.

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The possibility to shape stimulus-responsive optical polymers, especially hydrogels, by means of laser 3D printing and ablation is fostering a new concept of “smart” micro-devices that can be used for imaging, thermal stimulation, energy transducing and sensing. The composition of these polymeric blends is an essential parameter to tune their properties as actuators and/or sensing platforms and to determine the elasto-mechanical characteristics of the printed hydrogel. In light of the increasing demand for micro-devices for nanomedicine and personalized medicine, interest is growing in the combination of composite and hybrid photo-responsive materials and digital micro-/nano-manufacturing. Existing works have exploited multiphoton laser photo-polymerization to obtain fine 3D microstructures in hydrogels in an additive manufacturing approach or exploited laser ablation of preformed hydrogels to carve 3D cavities. Less often, the two approaches have been combined and active nanomaterials have been embedded in the microstructures. The aim of this review is to give a short overview of the most recent and prominent results in the field of multiphoton laser direct writing of biocompatible hydrogels that embed active nanomaterials not interfering with the writing process and endowing the biocompatible microstructures with physically or chemically activable features such as photothermal activity, chemical swelling and chemical sensing.

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29

Khodeir, Miriam, He Jia, Alexandru Vlad, and Jean-François Gohy. "Application of Redox-Responsive Hydrogels Based on 2,2,6,6-Tetramethyl-1-Piperidinyloxy Methacrylate and Oligo(Ethyleneglycol) Methacrylate in Controlled Release and Catalysis." Polymers 13, no. 8 (April 16, 2021): 1307. http://dx.doi.org/10.3390/polym13081307.

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Hydrogels have reached momentum due to their potential application in a variety of fields including their ability to deliver active molecules upon application of a specific chemical or physical stimulus and to act as easily recyclable catalysts in a green chemistry approach. In this paper, we demonstrate that the same redox-responsive hydrogels based on polymer networks containing 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) stable nitroxide radicals and oligoethylene glycol methyl ether methacrylate (OEGMA) can be successfully used either for the electrochemically triggered release of aspirin or as catalysts for the oxidation of primary alcohols into aldehydes. For the first application, we take the opportunity of the positive charges present on the oxoammonium groups of oxidized TEMPO to encapsulate negatively charged aspirin molecules. The further electrochemical reduction of oxoammonium groups into nitroxide radicals triggers the release of aspirin molecules. For the second application, our hydrogels are swelled with benzylic alcohol and tert-butyl nitrite as co-catalyst and the temperature is raised to 50 °C to start the oxidation reaction. Interestingly enough, benzaldehyde is not miscible with our hydrogels and phase-separate on top of them allowing the easy recovery of the reaction product and the recyclability of the hydrogel catalyst.

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Elkhoury, Kamil, Polen Koçak, Alex Kang, Elmira Arab-Tehrany, Jennifer Ellis Ward, and Su Ryon Shin. "Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery." Pharmaceutics 12, no. 9 (September 7, 2020): 849. http://dx.doi.org/10.3390/pharmaceutics12090849.

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Smart engineered and naturally derived nanovesicles, capable of targeting specific tissues and cells and delivering bioactive molecules and drugs into them, are becoming important drug delivery systems. Liposomes stand out among different types of self-assembled nanovesicles, because of their amphiphilicity and non-toxic nature. By modifying their surfaces, liposomes can become stimulus-responsive, releasing their cargo on demand. Recently, the recognized role of exosomes in cell-cell communication and their ability to diffuse through tissues to find target cells have led to an increase in their usage as smart delivery systems. Moreover, engineering “smarter” delivery systems can be done by creating hybrid exosome-liposome nanocarriers via membrane fusion. These systems can be loaded in naturally derived hydrogels to achieve sustained and controlled drug delivery. Here, the focus is on evaluating the smart behavior of liposomes and exosomes, the fabrication of hybrid exosome-liposome nanovesicles, and the controlled delivery and routes of administration of a hydrogel matrix for drug delivery systems.

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Shi, Xiangning, Yudong Zheng, Cai Wang, Lina Yue, Kun Qiao, Guojie Wang, Luning Wang, and Haiyu Quan. "Dual stimulus responsive drug release under the interaction of pH value and pulsatile electric field for a bacterial cellulose/sodium alginate/multi-walled carbon nanotube hybrid hydrogel." RSC Advances 5, no. 52 (2015): 41820–29. http://dx.doi.org/10.1039/c5ra04897d.

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Hydrogels synthesized by SA, BC and MWCNTs was a pH and electric responsive drug delivery system. The combination stimuli-releasing had selectivity for the pH value. Pulsatile releasing pattern was also had selectivity for the pH value.

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Birajdar, Ravindra P., Sudha S. Patil, Vijaykumar V. Alange, and Raghavendra V. Kulkarni. "Electrically Triggered Transdermal Drug Delivery Utilizing Poly(Acrylamide)-graft-Guar Gum: Synthesis, Characterization and Formulation Development." Current Applied Polymer Science 3, no. 1 (January 9, 2019): 64–74. http://dx.doi.org/10.2174/2452271602666181031093243.

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Objective: The study aimed to prepare electrically-triggered transdermal drug delivery systems (ETDS) using electrically responsive polyacrylamide-graft-gaur gum (PAAm-g-GaG) copolymer. Methods: The PAAm-g-GaG copolymer was synthesized by adopting free radical polymerization grafting method. This PAAm-g-GaG copolymer hydrogel acts as a drug reservoir and blend films of Guar Gum (GaG) and Polyvinyl Alcohol (PVA) were included as Rate Controlling Membranes (RCM) in the system. The PAAm-g-GaG copolymer was characterized by FTIR, neutralization equivalent values, thermogravimetric analysis and elemental analysis. Results: On the basis of results obtained, it is implicit that the drug permeation decreased with an increase in the concentration of glutaraldehyde and RCM thickness; while drug permeation rate was increased with increasing applied electric current strength from 2 to 8 mA. A two fold increase in flux values was observed with the application of DC electric current. An increase in drug permeation was witnessed under on condition of electric stimulus and permeation was decreased when electric stimulus was "off". The skin histopathology study confirmed the changes in skin structure when electrical stimulus was applied. Conclusion: The electrically-sensitive PAAm-g-GaG copolymer is a useful biomaterial for transdermal drug delivery application.

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Emi, Tania, Kendra Michaud, Emma Orton, Grace Santilli, Catherine Linh, Meaghan O’Connell, Fatima Issa, and Stephen Kennedy. "Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels." Molecules 24, no. 6 (March 16, 2019): 1048. http://dx.doi.org/10.3390/molecules24061048.

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Control over of biological processes can potentially be therapeutically regulated through localized biomolecular deliveries. While implantable hydrogels can provide localized therapeutic deliveries, they do not traditionally provide the temporally complex therapeutic delivery profiles required to regulate complex biological processes. Ionically crosslinked alginate hydrogels have been shown to release encapsulated payloads in response to a remotely applied ultrasonic stimulus, thus potentially enabling more temporally complex therapeutic delivery profiles. However, thorough characterizations of how different types of therapeutic payloads are retained and ultrasonically released need to be performed. Additionally, the impact of potentially disruptive ultrasonic stimulations on hydrogel structure and temperature need to be characterized to better understand what range of ultrasonic signals can be used to trigger release. To perform these characterizations, calcium-crosslinked alginate hydrogels were loaded with various model macromolecules (dextrans), chemotherapeutics, and protein signaling factors and exposed to a variety of single-pulse and multi-pulse ultrasonic signals at various amplitudes and durations. In response to single-pulsed ultrasonic exposures, quantifications of molecular release, degree of gel erosion, and increase in hydrogel temperature revealed that the ultrasonic stimulations required for statistically significant therapeutic deliveries often eroded and heated the gels to unacceptable levels. However, multi-pulse ultrasonic exposures were shown to achieve significant amounts of therapeutic release while keeping gel erosion and temperature increase at modest levels. Finally, experiments were performed demonstrating that ultrasonic stimulation could be used to generate drug release profiles shown to have potential therapeutic benefits (e.g., pulsatile and sequential anticancer delivery profiles). This work underscores the potential of using ultrasonically responsive polymeric hydrogels for providing on-demand control over more complex therapeutic deliver profiles and enhancing drug delivery strategies in cancer therapies and beyond.

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Laird, Dougal, Marie Daoud El-Baba, Ghislaine Charpin-El Hamri, Philipp Eberwein, Katja Nelson, Pascal Tomakidi, and Thorsten Steinberg. "In vitro and in vivo biocompatibility evaluation of a novobiocin stimulus-responsive poly(ethylene glycol)-based hydrogel designed for soft tissue regeneration." Journal of Bioactive and Compatible Polymers 30, no. 3 (February 10, 2015): 319–39. http://dx.doi.org/10.1177/0883911515570370.

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Das, Dipankar, Paulomi Ghosh, Animesh Ghosh, Chanchal Haldar, Santanu Dhara, Asit Baran Panda, and Sagar Pal. "Stimulus-Responsive, Biodegradable, Biocompatible, Covalently Cross-Linked Hydrogel Based on Dextrin and Poly(N-isopropylacrylamide) for in Vitro/in Vivo Controlled Drug Release." ACS Applied Materials & Interfaces 7, no. 26 (June 29, 2015): 14338–51. http://dx.doi.org/10.1021/acsami.5b02975.

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Chang, Debby P., John E. Dolbow, and Stefan Zauscher. "Switchable Friction of Stimulus-Responsive Hydrogels†." Langmuir 23, no. 1 (January 2007): 250–57. http://dx.doi.org/10.1021/la0617006.

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Madsen, Jeppe, and Steven P. Armes. "(Meth)acrylic stimulus-responsive block copolymer hydrogels." Soft Matter 8, no. 3 (2012): 592–605. http://dx.doi.org/10.1039/c1sm06035j.

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Cheng, Qiuhong, Aiyou Hao, and Pengyao Xing. "Stimulus-responsive luminescent hydrogels: Design and applications." Advances in Colloid and Interface Science 286 (December 2020): 102301. http://dx.doi.org/10.1016/j.cis.2020.102301.

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Koetting, Michael C., Jonathan T. Peters, Stephanie D. Steichen, and Nicholas A. Peppas. "Stimulus-responsive hydrogels: Theory, modern advances, and applications." Materials Science and Engineering: R: Reports 93 (July 2015): 1–49. http://dx.doi.org/10.1016/j.mser.2015.04.001.

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Meister, Annette, Martin Bastrop, Sven Koschoreck, Vasil M. Garamus, Thomas Sinemus, Günter Hempel, Simon Drescher, et al. "Structure−Property Relationship in Stimulus-Responsive Bolaamphiphile Hydrogels." Langmuir 23, no. 14 (July 2007): 7715–23. http://dx.doi.org/10.1021/la7003479.

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Li, Hua, Rongmo Luo, and K. Y. Lam. "Modeling of ionic transport in electric-stimulus-responsive hydrogels." Journal of Membrane Science 289, no. 1-2 (February 2007): 284–96. http://dx.doi.org/10.1016/j.memsci.2006.12.011.

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Soppimath, K. S., T. M. Aminabhavi, A. M. Dave, S. G. Kumbar, and W. E. Rudzinski. "Stimulus-Responsive “Smart” Hydrogels as Novel Drug Delivery Systems." Drug Development and Industrial Pharmacy 28, no. 8 (January 2002): 957–74. http://dx.doi.org/10.1081/ddc-120006428.

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Chen, Y., W. Y. Liu, and G. S. Zeng. "Stimulus-responsive hydrogels reinforced by cellulose nanowhisker for controlled drug release." RSC Advances 6, no. 90 (2016): 87422–32. http://dx.doi.org/10.1039/c6ra14421g.

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Liu, Bing, Tao Yang, Xin Mu, Zhijian Mai, Hao Li, Yao Wang, and Guofu Zhou. "Smart Supramolecular Self-Assembled Nanosystem: Stimulus-Responsive Hydrogen-Bonded Liquid Crystals." Nanomaterials 11, no. 2 (February 10, 2021): 448. http://dx.doi.org/10.3390/nano11020448.

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Abstract:

In a liquid crystal (LC) state, specific orientations and alignments of LC molecules produce outstanding anisotropy in structure and properties, followed by diverse optoelectronic functions. Besides organic LC molecules, other nonclassical components, including inorganic nanomaterials, are capable of self-assembling into oriented supramolecular LC mesophases by non-covalent interactions. Particularly, huge differences in size, shape, structure and properties within these components gives LC supramolecules higher anisotropy and feasibility. Therefore, hydrogen bonds have been viewed as the best and the most common option for supramolecular LCs, owing to their high selectivity and directionality. In this review, we summarize the newest advances in self-assembled structure, stimulus-responsive capability and application of supramolecular hydrogen-bonded LC nanosystems, to provide novel and immense potential for advancing LC technology.

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Boothby, Jennifer M., Jeremy Samuel, and Taylor H. Ware. "Molecularly-ordered hydrogels with controllable, anisotropic stimulus response." Soft Matter 15, no. 22 (2019): 4508–17. http://dx.doi.org/10.1039/c9sm00763f.

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Basuki, Kris Tri, Deni Swantomo, Sigit, and Kartini Megasari. "Effect of Deacetylation on Characterization of pH Stimulus Responsive Chitosan-Acrylamide Hydrogels Using Radiation." Advanced Materials Research 896 (February 2014): 292–95. http://dx.doi.org/10.4028/www.scientific.net/amr.896.292.

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Abstract:

Smart hydrogels which can change their swelling behavior and other properties in response to environmental stimuli such as temperature, pH, solvent composition and electric fields, have attracted great interest as chemical sensor material and controlled release system. The pH stimulus responsive hydrogels were synthesized by gamma-irradiation graft copolymerization of chitosan-acrylamide. In this research the influence of deacetylation process on the hydrogels characterization were investigated by measuring grafting efficiency, gel fraction, swelling degree, and crosslink density. Evidence of grafting was confirmed by FTIR spectroscopy. X-ray diffraction showed reduction in the crystallinity of chitosan with different deacetylation process also after the graft copolymerization reaction. The results showed that decreasing acetyl group of chitosan increase the grafting efficiency, gel fraction and swelling degree. While crystallinity decreased. The hydrogels indicated pH-dependent swelling behaviour.

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Ikeda, Masato, Tatsuya Tanida, Tatsuyuki Yoshii, and Itaru Hamachi. "Rational Molecular Design of Stimulus-Responsive Supramolecular Hydrogels Based on Dipeptides." Advanced Materials 23, no. 25 (April 29, 2011): 2819–22. http://dx.doi.org/10.1002/adma.201004658.

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Yan, Diwei, Sa Liu, Yong‐Guang Jia, Lina Mo, Dawei Qi, Jin Wang, Yunhua Chen, and Li Ren. "Responsive Polypseudorotaxane Hydrogels Triggered by a Compatible Stimulus of CO 2." Macromolecular Chemistry and Physics 220, no. 12 (May 9, 2019): 1900071. http://dx.doi.org/10.1002/macp.201900071.

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Luo, Rongmo, Hua Li, Erik Birgersson, and Khin Yong Lam. "Modeling of electric-stimulus-responsive hydrogels immersed in different bathing solutions." Journal of Biomedical Materials Research Part A 85A, no. 1 (2008): 248–57. http://dx.doi.org/10.1002/jbm.a.31586.

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Wang, Dong, and Jingcheng Hao. "Multiple-stimulus-responsive hydrogels of cationic surfactants and azoic salt mixtures." Colloid and Polymer Science 291, no. 12 (August 11, 2013): 2935–46. http://dx.doi.org/10.1007/s00396-013-3036-4.

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