Academic literature on the topic 'Sterols'

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Journal articles on the topic "Sterols"

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Tang, Rui, Junhao Liang, Xiangfeng Jing, and Tongxian Liu. "Discrepancy in Sterol Usage between Two Polyphagous Caterpillars, Mythimna separata and Spodoptera frugiperda." Insects 13, no. 10 (September 27, 2022): 876. http://dx.doi.org/10.3390/insects13100876.

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Insects are sterol auxotrophs and typically obtain sterols from food. However, the sterol demand and metabolic capacity vary greatly among species, even for closely related species. The low survival of many insects on atypical sterols, such as cholestanol and cholestanone, raises the possibility of using sterol-modified plants to control insect herbivore pests. In this study, we evaluated two devastating migratory crop pests, Mythimna separata and Spodoptera frugiperda, in response to atypical sterols and explored the reasons that caused the divergences in sterol nutritional biology between them. Contrary to M. separata, S. frugiperda had unexpectedly high survival on cholestanone, and nearly 80% of the individuals pupated. Comparative studies, including insect response to multiple diets and larval body sterol/steroids analysis, were performed to explain their differences in cholestanone usage. Our results showed that, in comparison to M. separata, the superiority of S. frugiperda on cholestanone can be attributed to its higher efficiency of converting ketone into available stanol and its lower demand for sterols, which resulted in a better survival when cholesterol was unavailable. This research will help us to better understand insect sterol nutritional biology and the potential of using atypical sterols to control herbivorous insect pests.
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Lobastova, Tatyana, Victoria Fokina, Irina Pozdnyakova-Filatova, Sergey Tarlachkov, Andrey Shutov, and Marina Donova. "Insight into Different Stages of Steroid Degradation in Thermophilic Saccharopolyspora hirsuta VKM Ac-666T Strain." International Journal of Molecular Sciences 23, no. 24 (December 18, 2022): 16174. http://dx.doi.org/10.3390/ijms232416174.

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Steroids are abundant molecules in nature, and various microorganisms evolved to utilize steroids. Thermophilic actinobacteria play an important role in such processes. However, very few thermophiles have so far been reported capable of degrading or modifying natural sterols. Recently, genes putatively involved in the sterol catabolic pathway have been revealed in the moderately thermophilic actinobacterium Saccharopolyspora hirsuta VKM Ac-666T, but peculiarities of strain activity toward sterols are still poorly understood. S. hirsuta catalyzed cholesterol bioconversion at a rate significantly inferior to that observed for mesophilic actinobacteria (mycobacteria and rhodococci). Several genes related to different stages of steroid catabolism increased their expression in response to cholesterol as was shown by transcriptomic studies and verified by RT–qPCR. Sequential activation of genes related to the initial step of cholesterol side chain oxidation (cyp125) and later steps of steroid core degradation (kstD3, kshA, ipdF, and fadE30) was demonstrated for the first time. The activation correlates with a low cholesterol conversion rate and intermediate accumulation by the strain. The transcriptomic analyses revealed that the genes involved in sterol catabolism are linked functionally, but not transcriptionally. The results contribute to the knowledge on steroid catabolism in thermophilic actinobacteria and could be used at the engineering of microbial catalysts.
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Byakov, Artem, Mikhail Karpov, Nikolai Strizhov, and Marina Donova. "Creation and Characterization of Mycolicibacterium Smegmatis mc2155 with Deletions in Genes Encoding Sterol Oxidation Enzymes." BIO Web of Conferences 57 (2023): 03004. http://dx.doi.org/10.1051/bioconf/20235703004.

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The fast-growing saprotrophic strain Mycolicibacterium smegmatis mc2155 is capable of utilizing plant and animal sterols and can be used for creation of genetically engineered strains producing biologically active steroids. Oxidation of the 3β-hydroxyl group and Δ5(6)→Δ4(5) double bond isomerization followed by formation of stenones from sterols are considered as the initial stage of steroid catabolism in some actinobacteria. The study of the mechanism of steroid nucleus 3β-hydroxyl group oxidation is relevant for the creation of a method of the microbiological production of valuable 3β-hydroxy-5-en-steroids. A mutant strain of M. smegmatis with deletions in three genes (MSMEG_1604, MSMEG_5228 and MSMEG_5233) encoding known enzymes exhibiting 3β-hydroxysteroid dehydrogenase activity was constructed by homologous recombination coupled with double selection. The resulting mutant retained macromorphological properties and the ability to convert cholesterol. 3-Keto-4-en-steroids were found among the sterol catabolism intermediates. Experimentally obtained data indicate the presence of a previously undetected intracellular enzyme that performs the function of 3β-hydroxysteroid dehydrogenase/Δ5(6)→Δ4(5) isomerase.
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Morikawa, T., M. Mizutani, and D. Ohta. "Cytochrome P450 subfamily CYP710A genes encode sterol C-22 desaturase in plants." Biochemical Society Transactions 34, no. 6 (October 25, 2006): 1202–5. http://dx.doi.org/10.1042/bst0341202.

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Sterols are isoprenoid-derived lipids that are produced via the mevalonate pathway and are involved in various cellular functions in eukaryotes such as maintenance of membrane integrity and biosynthetic precursors of steroid hormones. Among cellular sterols, Δ22-sterols containing a double bond at C-22 in the sterol side chain specifically occur in fungi (ergosterol) and plants (stigmasterol and brassicasterol), and several lines of experimental evidence have suggested specific physiological roles of Δ22-sterols in plants. Fungal cytochrome P450 (P450), CYP61, has been established as the sterol C-22 desaturase functioning at the penultimate step in the ergosterol biosynthetic pathway. On the other hand, no particular sequence has been assigned as to the enzyme responsible for the introduction of the double bond into the sterol side chain in plants. In this review, we summarize our recent findings demonstrating that CYP710A P450 family genes encode the plant sterol C-22 desaturases to produce stigmasterol and brassicasterol/crinosterol from β-sitosterol and 24-epi-campesterol respectively.
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Urbina, J. A., G. Visbal, L. M. Contreras, G. McLaughlin, and R. Docampo. "Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii." Antimicrobial Agents and Chemotherapy 41, no. 7 (July 1997): 1428–32. http://dx.doi.org/10.1128/aac.41.7.1428.

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Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 sterols). In both cases the final products are 24-alkyl sterols, resulting from the action of delta24(25) and delta24(24') sterol methyltransferases, enzymes not present in vertebrates. To investigate the physiological significance of these sterols, cultures of P. carinii in embryonic lung cells were exposed to 22,26-azasterol (20-piperidin-2-yl-5alpha-pregnan-3beta-20(R)-diol), a compound previously shown to inhibit both enzymes and to halt cell proliferation in fungi and protozoa. This compound produced a dose-dependent reduction in the parasite proliferation, with a 50% inhibitory concentration of 0.3 microM and 80% reduction of growth after 96 h at 10 microM. Correspondingly, parasites treated with the azasterol at 10 microM for 48 h accumulated 24-desalkyl sterols such as zymosterol (cholesta-8,24-dien-3beta-ol) and cholesta-8,14,24-trien-3beta-ol to ca. 40% of the total mass of endogenous sterols. This is the first report on the antiproliferative effects of a sterol biosynthesis inhibitor on P. carinii and indicate that sterol methyltransferase inhibitors could be the basis of a novel and specific chemotherapeutic approach to the treatment of P. carinii infections.
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Shen, Yan, Volker Thiel, Pablo Suarez-Gonzalez, Sebastiaan W. Rampen, and Joachim Reitner. "Sterol preservation in hypersaline microbial mats." Biogeosciences 17, no. 3 (February 7, 2020): 649–66. http://dx.doi.org/10.5194/bg-17-649-2020.

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Abstract. Microbial mats are self-sustaining benthic ecosystems composed of highly diverse microbial communities. It has been proposed that microbial mats were widespread in Proterozoic marine environments, prior to the emergence of bioturbating organisms at the Precambrian–Cambrian transition. One characteristic feature of Precambrian biomarker records is that steranes are typically absent or occur in very low concentrations. This has been explained by low eukaryotic source inputs, or degradation of primary produced sterols in benthic microbial mats (“mat-seal effect”). To better understand the preservational pathways of sterols in microbial mats, we analyzed freely extractable and carbonate-bound lipid fractions as well as decalcified extraction residues in different layers of a recent calcifying mat (∼1500 years) from the hypersaline Lake 2 on the island of Kiritimati, central Pacific. A variety of C27–C29 sterols and distinctive C31 4α-methylsterols (4α-methylgorgosterol and 4α-methylgorgostanol, biomarkers for dinoflagellates) were detected in freely extractable and carbonate-bound lipid pools. These sterols most likely originated from organisms living in the water column and the upper mat layers. This autochthonous biomass experienced progressive microbial transformation and degradation in the microbial mat, as reflected by a significant drop in total sterol concentrations, up to 98 %, in the deeper layers, and a concomitant decrease in total organic carbon. Carbonate-bound sterols were generally low in abundance compared to the freely extractable portion, suggesting that incorporation into the mineral matrix does not play a major role in the preservation of eukaryotic sterols in this mat. Likewise, pyrolysis of extraction residues suggested that sequestration of steroid carbon skeletons into insoluble organic matter was low compared to hopanoids. Taken together, our findings argue for a major mat-seal effect affecting the distribution and preservation of steroids in the mat studied. This result markedly differs from recent findings made for another microbial mat growing in the nearby hypersaline Lake 22 on the same island, where sterols showed no systematic decrease with depth. The observed discrepancies in the taphonomic pathways of sterols in microbial mats from Kiritimati may be linked to multiple biotic and abiotic factors including salinity and periods of subaerial exposure, implying that caution has to be exercised in the interpretation of sterol distributions in modern and ancient microbial mat settings.
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Kopylov, Arthur T., Kristina A. Malsagova, Alexander A. Stepanov, and Anna L. Kaysheva. "Diversity of Plant Sterols Metabolism: The Impact on Human Health, Sport, and Accumulation of Contaminating Sterols." Nutrients 13, no. 5 (May 12, 2021): 1623. http://dx.doi.org/10.3390/nu13051623.

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The way of plant sterols transformation and their benefits for humans is still a question under the massive continuing revision. In fact, there are no receptors for binding with sterols in mammalians. However, possible biotransformation to steroids that can be catalyzed by gastro-intestinal microflora, microbial cells in prebiotics or cytochromes system were repeatedly reported. Some products of sterols metabolization are capable to imitate resident human steroids and compete with them for the binding with corresponding receptors, thus affecting endocrine balance and entire physiology condition. There are also tremendous reports about the natural origination of mammalian steroid hormones in plants and corresponding receptors for their binding. Some investigations and reports warn about anabolic effect of sterols, however, there are many researchers who are reluctant to believe in and have strong opposing arguments. We encounter plant sterols everywhere: in food, in pharmacy, in cosmetics, but still know little about their diverse properties and, hence, their exact impact on our life. Most of our knowledge is limited to their cholesterol-lowering influence and protective effect against cardiovascular disease. However, the world of plant sterols is significantly wider if we consider the thousands of publications released over the past 10 years.
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Vidkjær, Nanna H., Karl-Martin V. Jensen, René Gislum, and Inge S. Fomsgaard. "Profiling and Metabolism of Sterols in the Weaver Ant Genus Oecophylla." Natural Product Communications 11, no. 1 (January 2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100114.

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Sterols are essential to insects because they are vital for many biochemical processes, nevertheless insects cannot synthesize sterols but have to acquire them through their diet. Studies of sterols in ants are sparse and here the sterols of the weaver ant genus Oecophylla are identified for the first time. The sterol profile and the dietary sterols provided to a laboratory Oecophylla longinoda colony were analyzed. Most sterols originated from the diet, except one, which was probably formed via dealkylation in the ants and two sterols of fungal origin, which likely originate from hitherto unidentified endosymbionts responsible for supplying these two compounds. The sterol profile of a wild Oecophylla smaragdina colony was also investigated. Remarkable qualitative similarities were established between the two species despite the differences in diet, species, and origin. This may reflect a common sterol need/aversion in the weaver ants. Additionally, each individual caste of both species displayed unique sterol profiles.
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Raederstorff, D., and M. Rohmer. "Sterol biosynthesis de nova via cycloartenol by the soil amoeba Acanthamoeba polyphaga." Biochemical Journal 231, no. 3 (November 1, 1985): 609–15. http://dx.doi.org/10.1042/bj2310609.

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The soil amoeba Acanthamoeba polyphaga is capable of synthesizing its sterols de novo from acetate. The major sterols are ergosterol and poriferasta-5,7,22-trienol. Furthermore C28 and C29 sterols of still unknown structure with an aromatic B-ring are also synthesized by the amoeba. The first cyclic sterol precursor is cycloartenol, which is the sterol precursor in all photosynthetic phyla. No trace of lanosterol, which is the sterol precursor in animals and fungi, could be detected. These results show that at least some of the biochemical processes of Acanthamoeba polyphaga might be phylogenetically related to those of unicellular algae. Addition of exogenous sterols to the culture medium does not influence the sterol biosynthesis and the sterol composition of the cells.
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Behmer, S. T., D. O. Elias, and E. A. Bernays. "Post-ingestive feedbacks and associative learning regulate the intake of unsuitable sterols in a generalist grasshopper." Journal of Experimental Biology 202, no. 6 (March 15, 1999): 739–48. http://dx.doi.org/10.1242/jeb.202.6.739.

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Behavioural studies of the grasshopper Schistocerca americana were undertaken to identify the mechanisms that regulate the intake of dietary sterols. In the first experiment, grasshoppers were allowed to feed on spinach, a plant containing only unsuitable sterols; immediately after this first meal, a suitable or unsuitable sterol was injected into the haemolymph. Grasshoppers injected with unsuitable sterols had second meals on spinach that were significantly shorter than those of grasshoppers injected with suitable sterols, indicating that unsuitable dietary sterols are detected post-ingestively. In the second experiment, grasshoppers were fed food containing only unsuitable sterols and were then presented with glass-fibre discs containing different concentrations of a suitable sterol or sucrose only (the control). The results suggest that grasshoppers do not use a direct feedback operating on mouthpart chemoreceptors to regulate their intake of suitable sterols. In the third experiment, grasshoppers were presented with artificial diets containing different sterols and flavours, and feeding was observed over a sequence of meals. The results from both the first and last experiments suggest a role for associative learning in regulating the intake of unsuitable sterols.
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Dissertations / Theses on the topic "Sterols"

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Al-Shakarchi, E. M. D. "Transformation of sterols in plant tissue cultures." Thesis, Bucks New University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384187.

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RONDET, SABINE. "Biosynthese des sterols : 4-carboxy-sterol decarboxylases de plante superieure et de levure ; identification, caracterisation et purification." Université Louis Pasteur (Strasbourg) (1971-2008), 1998. http://www.theses.fr/1998STR13225.

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La voie de biosynthese des sterols comporte deux etapes de demethylation en c4. Le systeme multienzymatique catalysant ce processus comprend au moins trois enzymes distinctes : la 4-methylsterol oxydase (4mo), la 4-carboxysterol decarboxylase (4cd) et la 3-ceto steroide oxydoreductase (3 cor). Nous avons pu, pour la premiere fois, identifier la 4cd de plante superieure et de levure dans des microsomes de zea mays et de saccharomyces cerevisiae, apres synthese de differents substrats et identification rigoureuse du produit de reaction, a savoir un 3-cetosteroide decarboxyle. Nous avons ensuite mis au point un test enzymatique operationnel et fiable, ce qui nous a permis d'etablir les parametres enzymologiques de la reaction. Les resultats indiquent notamment que l'etape de decarboxylation n'est pas limitante dans le processus global de demethylation des sterols en c4. Le mode d'action de la 4cd s'apparente a celui d'une 3-hydroxysterol deshydrogenase dependante de nad(p) -, nad + etant beaucoup plus efficace que nadp +. De plus, nous avons montre que la reaction catalysee par la 4cd est independante de l'oxygene moleculaire, ce qui indique l'existence de deux phases distinctes dans le processus de demethylation en c4, a savoir : une phase strictement dependante de l'oxygene catalysee par la 4mo, suivie d'une phase independante de l'oxygene, catalysee par la 4cd et la 3cor. La recherche d'inhibiteurs du systeme de demethylation en c4 nous a conduits a l'obtention de deux inhibiteurs efficaces de la 4mo et de la 4cd de mais respectivement. Nous avons entrepris la purification de la 4cd de mais et nous avons obtenu apres trois etapes de chromatographie (echange d'anions, affinite puis exclusion) un taux de purification de 300 a 500 fois, ce qui permet d'envisager le microsequencage de la proteine ou la production d'anticorps specifiques, dans l'optique du clonage du gene correspondant.
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Houweling, Adrielle H. "Efficacy of plant sterol treatment in individuals with high or low baseline levels of circulating plasma plant sterols." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101141.

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Plant sterols are effective cholesterol-lowering agents; however, recent evidence suggests that this treatment may not be safe and beneficial in all individuals. This study determined whether high and low baseline circulating plasma campesterol and sitosterol are related to subsequent changes in plasma LDL-C, plant sterol or CRP levels, after accounting for plant sterol supplementation in hypercholesterolemic men (n=82). This trial was a 2-phase randomized cross-over design consisting of a controlled diet with and without a dose of 2.0 g/d of plant sterols over 4 weeks. There was no significant difference in plasma LDL-C, in the elevation of plasma plant sterol or in the changes of CRP levels for high and low groups, respectively. In view of these data, a supplement of 2.0 g/d of plant sterols should be viewed as a safe and beneficial cholesterol-lowering therapy for all individuals, with respect to their baseline plasma plant sterol levels.
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Martin-Creuzburg, Dominik. "Sterols in daphnia nutrition: physiological and ecological consequences." Berlin Logos, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2780263&prov=M&dok_var=1&dok_ext=htm.

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MacLachlan, J. "Analytical studies of oxygenated sterols in human serum." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234856.

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Almeida, de Carvalho Maria Joao. "Sterol requirements in Drosophila melanogaster." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-24817.

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Sterol is an abundant component of eukaryotic cell membranes and is thought to influence membrane properties such as permeability, fluidity and microdomain formation. Drosophila is an excellent model system in which to study functional requirements for membrane sterol because, although it does not synthesize sterol, it nevertheless requires sterols to complete development. Moreover, Drosophila normally incorporates sterols into cell membranes. Thus, dietary sterol depletion can be used to specifically reduce membrane sterol levels. In contrast, vertebrates do synthesize cholesterol. In this way, sterol depletion in vertebrates demand the use of approaches such as chemical extractions, drug treatments or genetic manipulation which are prone to have side effects. We have controlled the level and type of dietary sterol available to developing Drosophila larvae in order to investigate the requirement for sterol in cell membranes, and to distinguish it from the function of sterol as a precursor for signaling molecules. Strikingly, we show that membrane sterol levels can be reduced 6-fold in most tissues without affecting cell or larval viability. Larvae respond to sterol depletion by arresting their growth and development, and by increasing the level of specific sphingolipid variants that promote survival when sterol is scarce. Thus, non-sterol lipids are able to substitute for sterols in the maintenance of basic membrane biophysical properties required for life. Despite this, Drosophila larvae regulate their growth to maintain membrane sterol levels within tight limits. The existence of this novel membrane sterol-dependent growth control mechanism indicates an important role for bulk membrane sterol in the tissue specific functions of differentiated cells.
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Tyle, Praveen. "Phytosterol stabilized emulsions /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487260859497823.

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Ntanios, Fady Y. "Cholesterol lowering efficacy of plant sterols : mechanisms of action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0018/NQ44534.pdf.

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Ali, Muftah Younis. "Studies on the sterols and chemotherapy of Leishmania mexicana." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337129.

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Barker, Gillian M. "Bile acids and neutral sterols in familial adenomatous polyposis." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308002.

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In familial adenomatous polyposis (FAP), inactivation of the APC gene is directly linked to the development of gastrointestinal polyps and cancer. It is likely that other epigenetic factors are involved in the malignant change of polyp to carcinoma. Previous studies have implied an abnormal bile acid profile, both in faeces and bile. In this study, using carefully matched control groups, extraction of bile acids from faeces and bile was performed and analysis was rigorously performed using Gas-liquid chromatography-Mass Spectrometry. No significant differences were found between the two groups in the profile of major bile acids. An increased faecal excretion of two minor bile acids, 5β-cholanoic acid-3α-ol-12-one and 5α-cholanoic acid-3α-ol-12-one and an increased level of 5β-cholanoic acid-3α-01-12-one in bile was found in patients with FAP. A difference in the faecal neutral sterol profile had also been suggested, but this study showed no significant difference between the two groups when matching controls are used. This study does not support the idea that there are significant differences in faecal bile acid, biliary bile acid or neutral sterol profiles between individuals with familial adenomatous polyposis and controls.
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Books on the topic "Sterols"

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1938-, Patterson Glenn W., Nes W. David, and American Oil Chemists' Society, eds. Physiology and biochemistry of sterols. Champaign, Ill: American Oil Chemists' Society, 1991.

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Rozman, Damjana, and Rolf Gebhardt, eds. Mammalian Sterols. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39684-8.

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S, Görög, ed. Steroid analysis in the pharmaceutical industry: Hormonal steroids, sterols, vitamins D, cardiac glycosides. Chichester, England: E. Horwood, 1989.

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David, Nes W., and Parish Edward J, eds. Analysis of sterols and other biologically significant steroids. San Diego: Academic Press, 1989.

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David, Nes W., and Parish Edward J, eds. Analysis of sterols and other biologically significant steroids. San Diego: Academic Press, 1988.

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Goad, L. John, and Toshihiro Akihisa. Analysis of Sterols. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-1447-6.

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Henry, Danielsson, and Sjövall Jan, eds. Sterols and bile acids. Amsterdam: Elsevier, 1985.

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J, Parish Edward, and Nes W. David, eds. Biochemistry and function of sterols. Boca Raton: CRC Press, 1997.

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Symposium on Lipoprotein and Cholesterol Metabolism in Steroidogenic Tissues (1984 Laval University). Lipoprotein and cholesterol metabolism in steroidogenic tissues. Philadelphia: Georg F. Stickley Co., 1985.

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V, Torgov I., and Kamernit͡s︡kiĭ A. V, eds. Khimii͡a︡ spirostanolov. Moskva: "Nauka", 1986.

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Book chapters on the topic "Sterols"

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Urich, Klaus. "Sterols and Steroids." In Comparative Animal Biochemistry, 624–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-06303-3_16.

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Small, Donald M. "Sterols and Sterol Esters." In The Physical Chemistry of Lipids, 395–473. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4899-5333-9_11.

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Bährle-Rapp, Marina. "sterols." In Springer Lexikon Kosmetik und Körperpflege, 532. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_10083.

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Leshem, Ya’Acov Y. "Sterols." In Plant Membranes, 57–64. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-017-2683-2_4.

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Guengerich, F. Peter, and Francis K. Yoshimoto. "Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids." In Mammalian Sterols, 145–71. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39684-8_7.

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Skubic, Cene, and Damjana Rozman. "Sterols from the Post-Lanosterol Part of Cholesterol Synthesis: Novel Signaling Players." In Mammalian Sterols, 1–22. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39684-8_1.

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Smith, Caitlin J., John M. Dagle, and Kelli K. Ryckman. "Genetic Variability in Cholesterol Metabolism." In Mammalian Sterols, 23–40. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39684-8_2.

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Björkhem, Ingemar, and Ulf Diczfalusy. "Side-Chain Oxidized Oxysterols in Health and Disease." In Mammalian Sterols, 41–79. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39684-8_3.

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Keitel, Verena, Christoph G. W. Gertzen, Sven Schäfer, Caroline Klindt, Christina Wöhler, Kathleen Deutschmann, Maria Reich, Holger Gohlke, and Dieter Häussinger. "Bile Acids and TGR5 (Gpbar1) Signaling." In Mammalian Sterols, 81–100. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39684-8_4.

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Matz-Soja, Madlen. "Bile Acids as Regulatory Signalling Molecules." In Mammalian Sterols, 101–16. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39684-8_5.

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Conference papers on the topic "Sterols"

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Yuangsawad, Ratanaporn, Sarawut Sinpichai, Arunrot Sukra, and Duangkamol Na-Ranong. "Free sterols from acid hydrolysis of steryl glucosides." In 2021 6th International Conference on Business and Industrial Research (ICBIR). IEEE, 2021. http://dx.doi.org/10.1109/icbir52339.2021.9465867.

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Shawar, L., G. Love, A. Zumberge, P. Cárdenas, J. Giner, and R. Summons. "C31 Sterols from Sponges and Their Neoproterozoic Fossil Counterparts." In IMOG 2023. European Association of Geoscientists & Engineers, 2023. http://dx.doi.org/10.3997/2214-4609.202333111.

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HAN, YAOLING, CUIWU LIN, AIJIN OU, and KEJIAN HUANG. "STUDIES ON THE STEROLS OF SPONGIA ZIMOCCA AUBSPECLES IRREGULARIA (LENDENFELD)." In Proceedings of the 4th International Conference. WORLD SCIENTIFIC, 2004. http://dx.doi.org/10.1142/9789812702623_0154.

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Nordin, N., and M. M. Ali. "Distribution of fecal sterols in surface sediment of Sungai Tebrau, Johor." In THE 2013 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2013 Postgraduate Colloquium. AIP Publishing LLC, 2013. http://dx.doi.org/10.1063/1.4858698.

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Green, Hilary, and Selina Wang. "Avocado oil chemical composition varies with harvest time, growing region, and fruit quality, demonstrating important considerations for standard development." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/xako6609.

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Avocado oil currently does not have standards in place to regulate its purity or quality. To set appropriate standards, factors that impact the chemical composition of avocado oil need to be better understood. To help address this, fruits from different regions were harvested throughout the year and processed using lab-scale equipment into oil. The oils’ purity (fatty acid profile, sterols, and triacylglycerols) and quality (free fatty acidity, peroxide value, and specific extinction in UV) were determined in addition to minor components such as tocopherols. It was discovered that growing region and harvest time had a greater impact on fatty acid and sterols profiles than using whole fruit verses only flesh to process the oil. The same standards are set for all avocado oils regardless of the country of origin, this finding indicates it will be important to ensure standards can accommodate oils from different regions. In addition, using poor quality fruit to make oil caused a significant increase in the free fatty acidity compared to using good quality fruit at the time of processing. This work determined a baseline for avocado oil quality parameters by extracting oil from ripe, good quality fruit, which can in turn can inform reasonable limits for avocado oil quality standards.
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Valitova, Yu N. "Cold stress in wheat seedlings: membrane sterols, phospholipids and active oxygen forms." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future". Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-93.

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Dreger, Mariola, Agnieszka Gryszczyńska, and Milena Szalata. "Content of Sterols in In Vitro Propagated Chamerion angustifolium (L.) Holub Plants." In IECPS 2021. Basel Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/iecps2021-12005.

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Chikaraishi, Y. "Hydrogen Isotopic Composition of Fatty Acids, Sterols, and Phytol: Autotrophic Vs. Heterotrophic Production." In 29th International Meeting on Organic Geochemistry. European Association of Geoscientists & Engineers, 2019. http://dx.doi.org/10.3997/2214-4609.201902871.

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Mascrez, Steven, Sabine Danthine, and Giorgia Purcaro. "A rapid and efficient method for dialkyl ketones and sterols determination in fat." In Virtual 2021 AOCS Annual Meeting & Expo. AOCS, 2021. http://dx.doi.org/10.21748/am21.496.

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Senik, S. V., T. L. Kolker, D. Yu Vlasov, A. L. Shavarda, and E. R. Kotlova. "Adaptation of basidiomycetes of the genus Gleophyllum totemperature changing: the role of sterols and triterpenes." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future". Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-393.

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Reports on the topic "Sterols"

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Winkler-Moser, Jill. Gas Chromatographic Analysis of Plant Sterols. AOCS, April 2011. http://dx.doi.org/10.21748/lipidlibrary.40384.

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Owings, Raymond. Isolation and characterization of two sterols from the green alga, Selenastrum capricornutum. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.861.

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Van Wychen, Stefanie R., and Lieve M. Laurens. Determination of Total Sterols in Microalgae by Acid Hydrolysis and Extraction: Laboratory Analytical Procedure (LAP). Issue Date: December 21, 2018. Office of Scientific and Technical Information (OSTI), December 2018. http://dx.doi.org/10.2172/1488917.

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Hodges, Thomas K., and David Gidoni. Regulated Expression of Yeast FLP Recombinase in Plant Cells. United States Department of Agriculture, September 2000. http://dx.doi.org/10.32747/2000.7574341.bard.

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Research activities in both our laboratories were directed toward development of control of the FLP/frt recombination system for plants. As described in the text of the research proposal, the US lab has been engaged in developing regulatory strategies such as tissue-specific promoters and the steroid-inducible activation of the FLP enzyme while the main research activities in Israel have been directed toward the development and testing of a copper-regulated expression of flp recombinase in tobacco (this is an example of a promoter activation by metal ions). The Israeli lab hat additionally completed experiments of previous studies regarding factors affecting the efficiency of recombinase activity using both a gain-of-function assay (excisional-activation of a gusA marker) and loss of function assay (excision of a rolC marker) in tobacco. Site-specific recombinase systems, in particular the FLP/frt and R/RS systems of yeast and the Cre/lox system of bacteriophage P1, have become an essential component of targeted genetic transformation procedures both in animal and plant organisms. To provide more flexibility in transgene excisions by the recombinase systems as well as gene targeting, and to widen possible applications, the development of controlled or regulated recombination systems is highly desirable and was therefore the subject of this research proposal. There are a few possible mechanisms to regulate expression of a recombinase system. They include: 1) control of the recombination system by having the target sites (e.g. frt) in one plant and the flp recombinase gene in another, and bringing the two together by cross fertilization. 2) regulation of promoter activities by external stimuli such as temperature, chemicals, metal ions, etc. 3) regulation of promoter activities by internal signals, i.e. cell- or tissue-specific, or developmental regulation. 4) regulation of enzyme activity by providing cofactors essential for biochemical reactions to take place such as steroid molecules in conjunction with a steroid ligand-binding protein (domains). During the course of this research our major emphasis have been focused toward studying the feasibility of hybrid seed production in Arabidopsis, using FLP/frt. Male-sterility was induced using the antisence of a pollen- and tapetum-specific gene, bcp1, isolated from Arabidopsis. The sterility inducing gene was flanked by frt sites. Upon cross pollination of flowers of male-sterile plants with pollen from FLP-containing plants, viable seeds were produced, and the progeny hybrid plants developed normally. The major achievement from this work is the first demonstration of using a site-specific recombinase to restore fertility in male-sterile plants (see attached paper, Luo et al., Plant J 2000; 23:423-430). The implication from this finding is that site-specific recombination systems can be applied in crop plants as a useful alternative method for hybrid seed production.
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El Halawani, Mohamed, and Israel Rozenboim. Environmental factors affecting the decline in reproductive efficiency of turkey hens: Mediation by vasoactive intestinal peptide. United States Department of Agriculture, January 2007. http://dx.doi.org/10.32747/2007.7696508.bard.

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Reproductive failure associated with heat stress is a well known phenomenon in avian species. Increased prolactin (PRL) levels in response to heat stress have been suggested as a mechanism involved in this reproductive malfunction. To test this hypothesis, laying female turkeys were subjected to 40°C for 12 h during the photo-phase daily or maintained at 24–26°C. Birds in each group received oral treatment with parachlorophenyalanine (PCPA; 50 mg/kg BW/day for 3 days), an inhibitor of serotonin (5-HT) biosynthesis; or immunized against vasoactive intestinal peptide (VIP). Both treatments are known to reduce circulating PRL levels. Non treated birds were included as controls. In the control group, high ambient temperature terminated egg laying, induced ovarian regression, reduced plasma luteinizing hormone (LH) and ovarian steroids (progesterone, testosterone, estradiol) levels, and increased plasma PRL levels and the incidence of incubation behavior. Pretreatment with PCPA reduced (P< 0.05) heat stress-induced decline in egg production, increase in PRL levels, and expression of incubation behavior. Plasma LH and ovarian steroid levels of heat stressed birds were restored to that of controls by PCPA treatment. As in PCPA-treated birds, VIP immunoneutralization of heat-stressed turkeys reduced (P< 0.05) circulating PRL levels and prevented the expression of incubation behavior. But it did not restore the decline in LH, ovarian steroids, and egg production (P> 0.05). The present findings indicate that the detrimental effect of high temperature on reproductive performance may not be related to the elevated PRL levels in heat-stressed birds but to mechanism(s) that involve 5-HT neurotransmission and the induction of hyperthermia.
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Koskinen, David Jason. MINOS Sterile Neutrino Search. Office of Scientific and Technical Information (OSTI), February 2009. http://dx.doi.org/10.2172/969510.

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Wallace, Margaret R. Steroid Hormones in NF1 Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, August 2005. http://dx.doi.org/10.21236/ada443895.

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Devan, Alena V. Sterile Neutrino Search with MINOS. Office of Scientific and Technical Information (OSTI), August 2015. http://dx.doi.org/10.2172/1221337.

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Jones, Benjamin J. P. Sterile Neutrinos in Cold Climates. Office of Scientific and Technical Information (OSTI), September 2015. http://dx.doi.org/10.2172/1221354.

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Dodelson, S., and L. M. Widrow. Sterile neutrinos as dark matter. Office of Scientific and Technical Information (OSTI), March 1993. http://dx.doi.org/10.2172/10146636.

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