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Journal articles on the topic 'Steroidal constituents'

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Author: Grafiati

Published: 18 May 2024

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1

Gan, Kim-Hong, Shieh-Hsieh Kuo, and Chun-Nan Lin. "Steroidal Constituents ofGanodermaapplanatumandGanodermaneo-japonicum." Journal of Natural Products 61, no. 11 (November 1998): 1421–22. http://dx.doi.org/10.1021/np980184j.

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2

Siddiqui, Bina Shaheen, Shahid Bader Usmani, Sabira Begum, and Salimuzzaman Siddiqui. "Steroidal Constituents of Holarrhena pubescens." Journal of Natural Products 57, no. 1 (January 1994): 27–31. http://dx.doi.org/10.1021/np50103a004.

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3

Hu, Ying-Jie, Xiao-Ling Shen, Qan-Zhang Mu, Yang Lu, and Qi-Tai Zheng. "Steroidal constituents from Amalocalyx yunnanesis." Phytochemistry 31, no. 6 (June 1992): 2099–102. http://dx.doi.org/10.1016/0031-9422(92)80370-t.

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4

Gaspar, Elvira M. M., and Higuinaldo J. C. das Neves. "Steroidal constituents from mature wheat straw." Phytochemistry 34, no. 2 (September 1993): 523–27. http://dx.doi.org/10.1016/0031-9422(93)80039-u.

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5

Ahmad, Ijaz, Abdul Malik, Nighat Afza, Itrat Anis, Itrat Fatima, Sarfraz Ahmad Nawaz, Rasool Bukhsh Tareen, and M. Iqbal Choudhary. "Enzymes Inhibitory Constituents From Buddleja Crispa." Zeitschrift für Naturforschung B 60, no. 3 (March 1, 2005): 341–46. http://dx.doi.org/10.1515/znb-2005-0319.

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Steroidal galactoside 1 and aryl esters 2 and 3 have been isolated from Buddleja crispa, along with ginipin 4, gardiol 5, 1-heptacosanol 6, and methyl benzoate 7, isolated for the first time from this species. The structures of all of the compounds were determined by spectroscopic techniques and chemical studies. The steroidal galactoside 1 is an inhibitor of lipoxygenase. Compounds 1- 3 displayed inhibitory activity against butyrylcholinesterse, while compounds 2 and 3 further showed inhibition against acetylcholinesterase

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6

Shah, Sherine Majeed, and Thukaa Z. Abdul-Jalil. "Qualitative and Quantitative Estimation or Chemical Constituents from Leaves and Roots of Iraqi Agave Attenuata by GC-MS and RP-HPLC(Conference Paper) #." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, Suppl. (February 16, 2023): 75–85. http://dx.doi.org/10.31351/vol31isssuppl.pp75-85.

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This research concentrate on cultivated Iraqi Agave attenuata dried leaves and roots, because of little studies on this plant especially on the root that lead to the eager of study and comparison of phytochemical constituents between leaves and root. Extraction of bioactive constituents was carried out using several solvents with increasing polarity (n-hexane, ethyl acetate and methanol) by soxhlet apparatus. Steroidal saponins in Agave genus is well documented in many species, lightening the minds in this research on extraction method which is specific for steroidal saponins. Phytochemical screening was done by GC/MS for n-hexane fraction, qualitative and quantitative estimation of several bioactive constituents (caffeic acid, p-coumaric acid, and quercetin) for ethyl acetate and methanol fractions while for steroidal saponins (sarsasapogenin, hecogenin and tigogenin) in both leaves and root by using reverse phase-high performance liquid chromatography (RP-HPLC). Among those identified phytochemical constituents, several constituents have not been detected in Agave attenuata leaves and roots before. This study is the first to describe the results in which the highest concentration of caffeic acid was found in leaves ethyl acetate fraction, p-coumaric acid and quercetin in root ethyl acetate fractions. While for steroidal saponins, the hecogenin, tigogenin and sarsasapogenin highest concentrations were found in leaves.

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7

Ivanchina, Natalia V., Alla A. Kicha, Anatoly I. Kalinovsky, Pavel S. Dmitrenok, Valentin A. Stonik, Ricardo Riguera, and Carlos Jiménez. "Hemolytic Polar Steroidal Constituents of the StarfishAphelasteriasjaponica." Journal of Natural Products 63, no. 8 (August 2000): 1178–81. http://dx.doi.org/10.1021/np000030f.

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8

Zaki, A., J. Schmidt, F. Hammouda, and G. Adam. "Steroidal Constituents from Pollen Grains ofPhoenix dactylifera." Planta Medica 59, S 1 (December 1993): A613—A614. http://dx.doi.org/10.1055/s-2006-959837.

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9

Mimaki, Yoshihiro, and Yutaka Sashida. "Steroidal and phenolic constituents of Lilium speciosum." Phytochemistry 30, no. 3 (January 1991): 937–40. http://dx.doi.org/10.1016/0031-9422(91)85283-6.

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10

YANG, Q., Y. ZHANG, H. LI, and C. YANG. "Polyhydroxylated steroidal constituents from the fresh rhizomes of." Steroids 70, no. 10 (September 2005): 732–37. http://dx.doi.org/10.1016/j.steroids.2005.04.003.

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11

LI, Yu-Ze, Hua-Wei ZHANG, Hao FAN, Xiao-Fei LIANG, Bei SONG, Huan CHEN, Wen-Li HUANG, Zheng-Gang YUE, Xiao-Mei SONG, and Jian-Li LIU. "Steroidal constituents from Helleborus thibetanus and their cytotoxicities." Chinese Journal of Natural Medicines 17, no. 10 (October 2019): 778–84. http://dx.doi.org/10.1016/s1875-5364(19)30094-9.

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12

Siddiqui, Bina S., Fayaz Ahmed, S. Kashif Ali, Sobiya Perwaiz, and Sabira Begum. "Steroidal constituents from the aerial parts ofLippia nodifloraLinn." Natural Product Research 23, no. 5 (March 20, 2009): 436–41. http://dx.doi.org/10.1080/14786410802044802.

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13

Goyal, Shivangi, Nidhi Gupta, and Sreemoyee Chatterjee. "Investigating Therapeutic Potential ofTrigonella foenum-graecumL. as Our Defense Mechanism against Several Human Diseases." Journal of Toxicology 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/1250387.

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Current lifestyle, stress, and pollution have dramatically enhanced the progression of several diseases in human. Globally, scientists are looking for therapeutic agents that can either cure or delay the onset of diseases. Medicinal plants from time immemorial have been used frequently in therapeutics. Of many such plants, fenugreek is one of the oldest herbs which have been identified as an important medicinal plant by the researchers around the world. It is potentially beneficial in a number of diseases such as diabetes, hypercholesterolemia, and inflammation and probably in several kinds of cancers. It has industrial applications such as synthesis of steroidal hormones. Its medicinal properties and their role in clinical domain can be attributed to its chemical constituents. The 3 major chemical constituents which have been identified as responsible for principle health effects are galactomannan, 4-OH isoleucine, and steroidal saponin. Numerous experiments have been carried outin vivoandin vitrofor beneficial effects of both the crude chemical and of its active constituent. Due to its role in health care, the functional food industry has referred to it as a potential nutraceutical. This paper is about various medicinal benefits of fenugreek and its potential application as therapeutic agent against several diseases.

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14

Wang, Shihan, Yang Xu, Yanwei Wang, Huailei Yang, Zuying Lv, Xiangqun Jin, and Yongsheng Wang. "Simultaneous Determination of Six Active Components in Oviductus Ranae via Quantitative Analysis of Multicomponents by Single Marker." Journal of Analytical Methods in Chemistry 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/9194847.

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A method, quantitative analysis of multicomponents by single marker (QAMS), was established in this article to investigate the quality control of a traditional Chinese medicine, Oviductus Ranae. 7-Hydroxycholesterol, 7-ketocholesterol, 4-cholesten-3-one, stigmasterol, 7-dehydrocholesterol, and cholesterol were selected as the indexes of quality evaluation of Oviductus Rana. The determination was achieved on an Agilent HC-C18 column (4.6 mm × 250 mm, 5 μm) using methanol with water (87 : 13 v/v) as mobile phase at the flow rate of 2.0 mL/min. Cholesterol was used as an internal standard to determine the relative correction factors between cholesterol and other steroidal constituents in Oviductus Ranae. The contents of those steroidal constituents were calculated at the same time. To evaluate the QAMS method, an external standard method was used to determine the contents of six steroidal constituents. No significant difference was observed when comparing the quantitative results of QAMS with the results of external standard method. The proposed QAMS method was proved to be accurate and feasible based on methodological experiments. QAMS provided a simple, efficient, economical, and accurate way to control the quality of Oviductus Ranae.

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15

Challinor, Victoria L., and James J. De Voss. "Assignment of stereochemistry in open-chain steroidal saponins." Pure and Applied Chemistry 84, no. 6 (February 6, 2012): 1469–78. http://dx.doi.org/10.1351/pac-con-11-09-12.

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The major phytochemical constituents of the widely used medicinal herb Chamaelirium luteum (“false unicorn”) are open-chain cholesterol-derived steroidal saponins. These are unusual in lacking the extra ring(s) derived from the steroidal side chain that are characteristic of the more commonly isolated furostanol and spirostanol saponins. The structures of the major steroidal saponins of C. luteum were determined using a combination of multistage mass spectrometry (MSn), 1D and 2D NMR experiments, and chemical degradation. The flexible nature of the steroidal side chain in these saponins necessitated determination of their absolute stereochemistry via total synthesis and X-ray crystallography.

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16

Zhao, Xueying, and Ji Li. "Chemical Constituents of the Genus Polygonatum and their Role in Medicinal Treatment." Natural Product Communications 10, no. 4 (April 2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000439.

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Polygonatum is a famous traditional Chinese medicine that is widely used in China, Korea and Japan. In the last decade, constituents of the genus have been reported including steroidal saponins, flavones, alkaloids, lignins, amino acids and carbohydrates, some of which show biological properties such as antiviral and antitumor activity, variable effects on the immune system and anticoagulant activity. In addition, some findings provide novel evidence that Polygonatum species may contain potential anti-tumor and anti-viral proteins for possible medical application and large-scale pharmaceutical production. In this review, we focus on the updated research of the chemical constituents of Polygonatum including polysaccharides, steroidal saponins, flavonoids and lectins, and their potential therapeutic roles.

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17

Cui, Yuwen, Xinjie Yang, Dongdong Zhang, Yuze Li, Li Zhang, Bei Song, Zhenggang Yue, Xiaomei Song, and Haifeng Tang. "Steroidal Constituents from Roots and Rhizomes of Smilacina japonica." Molecules 23, no. 4 (March 30, 2018): 798. http://dx.doi.org/10.3390/molecules23040798.

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18

Chung, Nguyen Dinh, Nguyen Phuong Thao, Ha Manh Tuan, Nguyen Van Thanh, Nguyen Hai Dang, Nguyen Thi Mai Huong, and Nguyen Tien Dat. "New Steroidal Glycoside and Flavonoid Constituents from Ophiopogon japonicus." Natural Product Communications 12, no. 6 (June 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200618.

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Chromatographic separations of a methanolic extract of Ophiopogon japonicus tubers resulted in the isolation of a new steroidal glycoside, (25 R)-ruscogenin 1- O-(4- O-sulfo)-β-D-fucopyranoside (1), a new C-methylflavonol, 3,4′-dimethoxy-3′,5,5′,7-tetrahydroxy-8-methylflavone (2), and a known flavonol, 3,4′-dimethoxy-3′,5,5′,7-tetrahydroxyflavone (3). The C-methylflavonol was reported for the first time from the genus Ophiopogon. Compound 1 showed moderate cytotoxicity against SK-Mel-2 and KB cells with IC50 values of 24.3 and 28.8 μM, respectively. Compound 2 was active on SK-Mel-2 cells (IC50 20.3 μM).

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19

Kaneda, Norito, Hiroyuki Nakanishi, and E. John Staba. "Steroidal constituents of Yucca shidigera plants and tissue cultures." Phytochemistry 26, no. 5 (April 1987): 1425–29. http://dx.doi.org/10.1016/s0031-9422(00)81827-0.

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20

Mallavadhani, U. V., A. V. S. Sudhakar, Anita Mahapatra, K. Narasimhan, M. Thirunavokkarasu, and John A. Elix. "Phenolic and steroidal constituents of the lichen Usnea longissima." Biochemical Systematics and Ecology 32, no. 1 (January 2004): 95–97. http://dx.doi.org/10.1016/s0305-1978(03)00187-x.

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21

MIMAKI, Yoshihiro, Tadashi SATOU, Minpei KURODA, Yutaka SASHIDA, and Yoshio HAYAKEYAMA. "New Steroidal Constituents from the Bulbs of Lilium candidum." CHEMICAL & PHARMACEUTICAL BULLETIN 46, no. 11 (1998): 1829–32. http://dx.doi.org/10.1248/cpb.46.1829.

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22

Wang, Huaxiang, Qi Zheng, Aijun Dong, Junchi Wang, and Jianyong Si. "Chemical Constituents, Biological Activities, and Proposed Biosynthetic Pathways of Steroidal Saponins from Healthy Nutritious Vegetable—Allium." Nutrients 15, no. 9 (May 8, 2023): 2233. http://dx.doi.org/10.3390/nu15092233.

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Allium is a common functional vegetable with edible and medicinal value. Allium plants have a special spicy taste, so they are often used as food and seasoning in people’s diets. As a functional food, Allium also has abundant biological activities, some of which are used as drugs to treat diseases. By consuming Allium on a daily basis, people can receive active compounds of natural origin, thereby improving their health status and reducing the likelihood of disease. Steroidal saponins are important secondary metabolites of Allium, which are formed by the steroidal aglycone group and sugar. Steroidal saponins have various physiological activities, such as hypoglycemic, antiplatelet aggregation, anti-inflammatory, antitumor, antimicrobial, and enzyme activity inhibition, which is one of the key reasons why Allium has such significant health benefits. The structural diversity and rich biological activities of steroidal saponins make Allium important plants for both food and medicine. In this paper, the chemical structures, biological activities, and structure–activity relationships of steroidal saponins isolated from Allium are reviewed, and the biosynthetic pathways of some key compounds are proposed as well, to provide a molecular reference basis based on secondary metabolites for the health value of Allium.

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23

Chou, Shen-Chieh, Tsurng-Juhn Huang, En-Hung Lin, Chun-Huei Huang, and Chang-Hung Chou. "Antihepatitis B Virus Constituents of Solanum Erianthum." Natural Product Communications 7, no. 2 (February 2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700205.

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Eleven compounds were isolated from the methanol extract of the leaves of Solanum erianthum D. Don, including five α-linolenic acid analogs, α-linolenic acid (1), 13 S-hydroxy-9( Z),11( E)-octadecadienoic acid (2), 9S-hydroxy-10( E),12( Z), 15( Z)-octadectrienoic acid (3), 9( Z),11( E)-octadecadienoic acid (4), and octadecanoic acid (5); two benzofuran-type lactones, loliolide (6) and dihydroactinidiolide (7); two steroidal alkaloids, solasonine (8) and solamargine (9); a flavonol glycoside, camelliaside C (10); and a flavone, 5-methoxy-(3″,4″-dihydro-3″,4″-diacetoxy)-2″,2″-dimethylpyrano-(7,8:5″,6″)-flavone (11). Among these isolated compounds, 9 showed the most potent activity against HBsAg, with an IC50 of 1.57 μM, followed by 8(IC50 is 5.89 μM). In the testing against HBeAg, 11 was the only active compound with an IC50 of 36.11 μM. Compound 9 also revealed strong inhibition of DNA replication towards HBV and its IC50 was 2.17 μM. However, α-linolenic acid (1) showed a prominent selected index (SI), both in anti-HBsAg and inhibition of DNA replication with SI values of 7.75 and 7.18, respectively. This is the first report that unsaturated fatty acid 1, steroidal alkaloid glycoside 9 and flavone 11, all showed excellent activity against HBV. These results provide lead candidates in the development of anti-HBV drugs from natural sources.

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24

Patel, Snehal S., and Jignasha K. Savjani. "Systematic review of plant steroids as potential anti-inflammatory agents: Current status and future perspectives." Journal of Phytopharmacology 4, no. 2 (April 25, 2015): 121–25. http://dx.doi.org/10.31254/phyto.2015.4212.

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Plant steroids are unique class of chemical compounds that are found throughout the animal and plant kingdom. Glucocorticoids are steroidal agents used to treat inflammatory disorders; on long term treatment it produces severe side effects. In order to overcome these undesirable consequences, investigations have to be made to identify novel bioactive phytochemicals with therapeutic potential with no or significantly reduced side effects. The objective of this review is to discuss medicinal plants having antiinflammatory activity and which contains chemical constituent such as solasodine, diosgenin, boswellic acid, glycyrrihizin, guggulsterones, withnolides or sarsasapogenin with structural similarity with glucocorticoids. These plant steroids classified in different classes based on their chemical structure, pharmacological activities and source from which they have been isolated. This review documents information on anti-inflammatory activity of plant containing steroids like chemical constituents such as Trigonella foenum graecum L. [Family: Fabaceae], Solanum xanthocarpum L. [Family: Solanaceae], Boswellia serrata Roxb. [Family: Burseraceae], Glycyrrhiza glabra L. [Family:Fabaceae], Commiphora mukul [family:Burseraceae], Withania sominifera [Family Solanaceae] by modern clinical and preclinical studies. There is an immense scope in investigation of the antiinflammatory activity of plant steroids structurally close to glucocorticoids in various inflammatory conditions. Further investigations are needed to explore the more potent lead compounds with lesser side effects.

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25

Odimegwu, Joy I., Olukemi Odukoya, Ritesh K. Yadav, C. S. Chanotiya, Steve Ogbonnia, and Neelam S. Sangwan. "A New Source of Elemol Rich Essential Oil and Existence of Multicellular Oil Glands in Leaves of theDioscoreaSpecies." Scientific World Journal 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/943598.

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Dioscoreaspecies is a very important food and drug plant. The tubers of the plant are extensively used in food and drug purposes owing to the presence of steroidal constituent’s diosgenin in the tubers. In the present study, we report for the first time that the leaves ofDioscorea compositaandDioscorea floribundagrown under the field conditions exhibited the presence of multicellular oil glands on the epidermal layers of the plants using stereomicroscopy (SM) and scanning electron microscopy (SEM). Essential oil was also isolated from the otherwise not useful herbage of the plant, and gas chromatographic-mass spectroscopy analysis revealed confirmation of the essential oil constituents. Out of the 76 compounds detected inD. floribundaand 37 fromD. compositaessential oil, major terpenoids which are detected and reported forDioscorealeaf essential oil areα-terpinene, nerolidol, citronellyl acetate, farnesol, elemol,α-farnesene, valerenyl acetate, and so forth. Elemol was detected as the major constituent of both theDioscoreaspecies occupying 41% and 22% ofD. FloribundaandD. compositaessential oils, respectively. In this paper, we report for the first timeDioscoreaas a possible novel bioresource for the essential oil besides its well-known importance for yielding diosgenin.

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26

Ling, Yun, Yihua Tang, Yuanyuan Xu, Qing Zhang, Chao Zhang, Yinyu Zhang, Youyan Chen, et al. "Rapid Screening and Identification of Chemical Constituents From Ophiopogon japonicus by High-Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry." Journal of Chromatographic Science 58, no. 7 (July 2, 2020): 641–50. http://dx.doi.org/10.1093/chromsci/bmaa029.

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Abstract Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), which is named as “Maidong” in China, is widely used in traditional Chinese medicine for treating fever, cough, inflammation, epistaxis, constipation, respiratory disease and gastrointestinal disorders. However, the systematic analysis of chemical constituents of O. japonicus has not been well established because of the complexity and trace. In this paper, an effective and reliable high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry method was successfully developed to separate and identify the chemical constituents from O. japonicus. As a result, a total of 30 compounds including steroidal saponins, homoisoflavonoids, allylbenzene, cholest and cryptomeridiol were screened or tentatively identified. Of them, three new steroidal saponins were found and tentatively characterized in O. japonicus. This study provides a meaningful material basis for further quality control and pharmacological research.

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27

ABE, Fumiko, Yujiro MORI, Hikaru OKABE, and Tatsuo YAMAUCHI. "Steroidal Constituents from the Roots and Stems of Asclepias fruticosa." CHEMICAL & PHARMACEUTICAL BULLETIN 42, no. 9 (1994): 1777–83. http://dx.doi.org/10.1248/cpb.42.1777.

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28

Simmons-Boyce, Joanne L., and Winston F. Tinto. "Steroidal Saponins and Sapogenins from the Agavaceae Family." Natural Product Communications 2, no. 1 (January 2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200120.

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Plants belonging to the family Agavaceae are used in folkloric medicinal practices worldwide and chemical investigations of these plants have shown that they are an abundant source of steroidal saponins and sapogenins. Despite the large number of secondary metabolites isolated from this family so far, there have been few reports on the bioactivity of these compounds. This article provides a comprehensive review of the steroidal constituents of plants from the genera Agave, Cordyline, Dracaena, Furcraea, Nolina, Sansevieria and Yucca up to June 2006, and reports on the bioactivity of these compounds where available.

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29

Qing, Lin-Sen, Ying Xue, Li-Sheng Ding, Yi-Ming Liu, Jian Liang, and Xun Liao. "A Rapid Study of Botanical Drug–Drug Interaction with Protein by Re-ligand Fishing using Human Serum Albumin–Functionalized Magnetic Nanoparticles." Natural Product Communications 10, no. 12 (December 2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001237.

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A great many active constituents of botanical drugs bind to human serum albumin (HSA) reversibly with a dynamic balance between the free- and bound-forms in blood. The curative or side effect of a drug depends on its free-form level, which is always influenced by other drugs, combined dosed or multi-constituents of botanical drugs. This paper presented a rapid and convenient methodology to investigate the drug-drug interactions with HSA. The interaction of two steroidal saponins, dioscin and pseudo-protodioscin, from a botanical drug was studied for their equilibrium time and equilibrium amount by re-ligand fishing using HSA functionalized magnetic nanoparticles. A clear competitive situation was obtained by this method. The equilibrium was reached soon about 15 s at a ratio of 0.44: 1. Furthermore, the interaction of pseudo-protodioscin to total steroidal saponins from DAXXK was also studied. The operation procedures of this method were faster and more convenient compared with other methods reported.

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30

Yuan, Wenjuan, Jinrong Ma, Xinlan Liu, Chengting Zi, Yongkai Xi, Xiaojing Shen, Guodong Li, Jun Sheng, and Xuanjun Wang. "Steroidal Alkaloids from the Roots of Veratrum mengtzeanum Loes. with Their Anti-Inflammatory Activities." Molecules 28, no. 20 (October 16, 2023): 7116. http://dx.doi.org/10.3390/molecules28207116.

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The phytochemical investigation of Veratrum mengtzeanum Loes. roots resulted in the isolation and characterization of two novel, namely Mengtzeanines A (1), Mengtzeanines B (2), and eight known steroidal alkaloids (3–10). Their structural properties were assessed though extensive spectroscopic techniques. All constituents 1–10 were analyzed for suppression of NO formation in LPS-induced RAW264.7 macrophages. Among them, constituent 6 (Verazine) showed inhibition against LPS-induced NO production (IC50 = 20.41 μM). Additionally, compound 6 could inhibit the secretion of IL1β, IL6, and TNFα, and downregulate the productions of iNOS and COX2 in LPS-induced RAW264.7 macrophages. Further experiments revealed that 6 exhibited a potent anti-inflammatory level in LPS-stimulated RAW264.7 macrophages via inhibiting NF-κB, and triggering of Keap1/Nrf2/HO-1 axis, implying that compound 6 may be a promising candidate for treating inflammatory disorders.

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31

Thao, Nguyen Phuong, Nguyen Xuan Cuong, Bui Thi Thuy Luyen, Nguyen Hoai Nam, Pham Van Cuong, Nguyen Van Thanh, Nguyen Xuan Nhiem, et al. "Steroidal Constituents from the Starfish Astropecten polyacanthus and Their Anticancer Effects." Chemical and Pharmaceutical Bulletin 61, no. 10 (2013): 1044–51. http://dx.doi.org/10.1248/cpb.c13-00490.

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32

MIMAKI, Yoshihiro, Yutaka SASHIDA, and Kazuhiro KAWASHIMA. "New Steroidal Constituents of the Bulbs of Camassia cusickii S. WATS." CHEMICAL & PHARMACEUTICAL BULLETIN 40, no. 1 (1992): 148–52. http://dx.doi.org/10.1248/cpb.40.148.

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33

Kim, Jinwoong, and A. Douglas Kinghorn. "Further steroidal and flavonoid constituents of the sweet plant, Polypodium glycyrrhiza." Phytochemistry 28, no. 4 (January 1989): 1225–28. http://dx.doi.org/10.1016/0031-9422(89)80214-6.

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34

Shen, Ji-Hui, Zhong-Liang Chen, and Yi-Sheng Gao. "The pentacyclic steroidal constituents of Tacca plantaginea: taccalonolide E and F." Chinese Journal of Chemistry 9, no. 1 (August 27, 2010): 92–94. http://dx.doi.org/10.1002/cjoc.19910090113.

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35

Mimaki, Yoshihiro, Tadaaki Satou, Minpei Kuroda, Yutaka Sashida, and Yoshio Hatakeyama. "ChemInform Abstract: New Steroidal Constituents from the Bulbs of Lilium candidum." ChemInform 30, no. 19 (June 16, 2010): no. http://dx.doi.org/10.1002/chin.199919215.

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36

Zhu, Yaoyao, Liling Wang, Meixu Chen, Yifeng Zhou, and Jun Huang. "Simultaneous Extraction and Determination of Characteristic Steroidal Saponins and Homoisoflavonoids in Zhejiang Ophiopogon japonicus." Molecules 27, no. 21 (October 30, 2022): 7380. http://dx.doi.org/10.3390/molecules27217380.

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Zhejiang Ophiopogonjaponicus (ZOJ) is a specific variety of Ophiopogon japonicus with characteristic steroidal saponins and homoisoflavonoids, which are also main pharmacodynamic constituents with clinical effects, including curing inflammation and cardiovascular diseases. However, few analysis methods were applied to simultaneously and quantitatively determine two kinds of its constituents, and hazardous organic solvents are mostly used for extraction. In this study, a new validated simultaneous extraction and determination method for four characteristic steroidal saponins and homoisoflavonoids in ZOJ was established by ionic liquid–ultrasonic extraction (IL-UAE) combined with HPLC-DAD-ELSD analysis, which can be used for the quality control of ZOJ. Chromatographic separation was performed with a DAD wavelength at 296 nm, and the ELSD parameters of the drift tube temperature (DTT), atomizer temperature (AT), and nitrogen gas pressure (NGP) were set at 20% heating power, 70 °C, and 25 psi, respectively. The optimal IL-UAE conditions were 1 mol/L [Bmim]CF3SO3 aqueous solution, a liquid–material ratio of 40 mL/g, and an ultrasonic time of 60 min. The proposed method is reliable, reproducible, and accurate, which were verified with real sample assays. Consequently, this work will be helpful for the quality control of ZOJ. It can also present a promising reference for the simultaneous extraction and determination of different kinds of constituents in other medicinal plants.

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Slavova, Iva, Teodora Tomova, Slavena Kusovska, Yoana Chukova, and Mariana Argirova. "Phytochemical Constituents and Pharmacological Potential of Tamus communis Rhizomes." Molecules 27, no. 6 (March 12, 2022): 1851. http://dx.doi.org/10.3390/molecules27061851.

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Tamus communis L. is a plant distributed in a number of geographical areas whose rhizome has been used for centuries as an anti-inflammatory and analgesic remedy. This review aims to summarize the current knowledge of the chemical composition and biological activity of the extracts or individual compounds of the rhizome. The data for the principal secondary metabolites are systematized: sterols, steroidal saponins, phenanthrenes, dihydrophenanthrenes, etc. Results of biological tests for anti-inflammatory action, cytotoxicity, anticholinesterase effect, and xanthine oxidase inhibition are presented. Some open questions about the therapeutic properties of the plant are also addressed.

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Reddy M., Swapna, and Ramya Kuber B. "ISOLATION, CHARACTERIZATION AND EVALUATION FOR ANTIPLASMODIAL ACTIVITY OF EXTRACTED CONSTITUENTS FROM CAESALPINIA CRISTA LINN SEEDS." Indian Drugs 60, no. 02 (March 2, 2023): 44–49. http://dx.doi.org/10.53879/id.60.02.11933.

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The present work deals with extraction, isolation and characterization of phytoconstituents from seeds of Caesalpinia crista Linn and the study of their antiplasmodial activity. The phytoconstituents were extracted using soxhlet apparatus and separated by column chromatography. Structural elucidation was done by FTIR spectroscopy, NMR spectroscopy and mass spectrometry. Terpenoid, saponin and steroidal glucocorticoid were successfully isolated and identified. These constituents were tested for antimalarial activity using Peter’s 4 day suppressive test. Antiplasmodial efficacy was evaluated by parasitemia levels, percentage inhibition, packed cell volume (PCV), survival period, body weight and rectal temperature change. From the ethyl acetate extract, the fractions obtained with a solvent system hexane:chloroform (4:6 v/v), hexane:chloroform (1:9 v/v) and chloroform:ethyl acetate (6:4 v/v) exhibited promising antimalarial activity and particularly first constituent showed significant (P<0.001) antiplasmodial activity than other two phytoconstituents in comparison with positive and negative control.

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Chawla, Amit, Payal Chawla, Mangalesh, and R. C. Roy. "Asparagus racemosus (Willd): Biological Activities & its Active Principles." Indo Global Journal of Pharmaceutical Sciences 01, no. 02 (2011): 113–20. http://dx.doi.org/10.35652/igjps.2011.11.

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Asparagus racemosus Willd. (Liliaceae) known as ‘Shatavari’. The major active constituents of Asparagus racemosus are steroidal saponins (Shatavarins I-IV). Isoflavones, Asparagamine, Racemosol, Polysaccharides, mucilage, vitamins A, B1 , B2 , C, E, Mg, P, Ca, Fe, and folic acid present in roots. Other primary chemical constituents of Asparagus are essential oils, asparagine, arginine, tyrosine, flavonoids (kaempferol, quercetin, and rutin), resin, and tannin. It is a well known Ayurvedic rasayana which prevent ageing, increase longevity, impart immunity, improve mental function, vigor and add vitality to the body. It is also used in nervous disorders, dyspepsia, tumors, inflammation, neuropathy and hepatopathy.© 2011 IGJPS. All rights reserved

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Lehra, K. S., S. Goyal, B. S. Bajwa, R. Kaur, and S. Singh. "ANTI-INFLAMMATORY AGENTS FROM PLANTS." INDIAN DRUGS 49, no. 04 (April 28, 2012): 5–11. http://dx.doi.org/10.53879/id.49.04.p0005.

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Most of the available non-steroidal anti-inflammatory drugs are devoid of gastro protective property.Therefore, the search for new anti-inflammatory agents from the huge array of medicinal plant resources is intensifying. Guggul sterones, boswellic acid, curcumin, withaferin-A and and rographolide have been reported to be promising anti-inflammatory agents in animal models. Scientists are of the view that there is acute shortage of leads for developing anti-inflammatory drugs. We need to initiate pending work on these phyto-constituents with emphasis on side effect profile. This paper provides an overview on the recent findings of some plants having anti-inflammatory activity and chemical constituents isolated from them.

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Shan, Lanlan, Yuanyuan Wu, Lei Yuan, Yani Zhang, Yanyan Xu, and Yubo Li. "Rapid Screening of Chemical Constituents in Rhizoma Anemarrhenae by UPLC-Q-TOF/MS Combined with Data Postprocessing Techniques." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/4032820.

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Rhizoma Anemarrhenae, a famous traditional Chinese medicine (TCM), is the dried rhizome of Anemarrhena asphodeloides Bge. (Anemarrhena Bunge of Liliaceae). The medicine presents anti-inflammatory, antipyretic, sedative, and diuretic effects. The chemical constituents of Rhizoma Anemarrhenae are complex and diverse, mainly including steroidal saponins, flavonoids, phenylpropanoids, benzophenones, and alkaloids. In this study, UPLC-Q-TOF/MS was used in combination with data postprocessing techniques, including characteristic fragments filter and neutral loss filter, to rapidly classify and identify the five types of substances in Rhizoma Anemarrhenae. On the basis of numerous literature reviews and according to the corresponding characteristic fragments produced by different types of compounds in combination with neutral loss filtering, we summarized the fragmentation patterns of the main five types of compounds and successfully screened and identified 32 chemical constituents in Rhizoma Anemarrhenae. The components included 18 steroidal saponins, 6 flavonoids, 4 phenylpropanoids, 2 alkaloids, and 2 benzophenones. The method established in this study provided necessary data for the study on the pharmacological effects of Rhizoma Anemarrhenae and also provided the basis for the chemical analysis and quality control of TCMs to promote the development of a method for chemical research on TCMs.

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Bhutani, K. K., A. T. Paul, W. Fayad, and S. Linder. "Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus." Phytomedicine 17, no. 10 (August 2010): 789–93. http://dx.doi.org/10.1016/j.phymed.2010.01.017.

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ANDO, Jun, Akiko MIYAZONO, Xing-Hua ZHU, Tsuyoshi IKEDA, and Toshihiro NOHARA. "Studies on the Constituents of Solanaceous Plants, Steroidal Glycosides from Solanum nodiflorum." CHEMICAL & PHARMACEUTICAL BULLETIN 47, no. 12 (1999): 1794–96. http://dx.doi.org/10.1248/cpb.47.1794.

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Mimaki, Yoshihiro, Yutaka Sashida, and Hiroko Shimomura. "Lipid and steroidal constituents of Lilium auratum var. Platyphyllum AND L. tenuifolium." Phytochemistry 28, no. 12 (January 1989): 3453–58. http://dx.doi.org/10.1016/0031-9422(89)80363-2.

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Zhao, Xuecheng, Yueran Zhang, Jun Lai, Yuan Deng, Yingchen Hao, Shouchuang Wang, and Jun Yang. "The SlDOG1 Affect Biosynthesis of Steroidal Glycoalkaloids by Regulating GAME Expression in Tomato." International Journal of Molecular Sciences 24, no. 4 (February 8, 2023): 3360. http://dx.doi.org/10.3390/ijms24043360.

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Steroidal alkaloids (SAs) and steroidal glycoalkaloids (SGAs) are common constituents of plant species belonging to the Solanaceae family. However, the molecular mechanism regulating the formation of SAs and SGAs remains unknown. Here, genome-wide association mapping was used to elucidate SA and SGA regulation in tomatoes: a SlGAME5-like glycosyltransferase (Solyc10g085240) and the transcription factor SlDOG1 (Solyc10g085210) were significantly associated with steroidal alkaloid composition. In this study, it was found that rSlGAME5-like can catalyze a variety of substrates for glycosidation and can catalyze SA and flavonol pathways to form O-glucoside and O-galactoside in vitro. The overexpression of SlGAME5-like promoted α-tomatine, hydroxytomatine, and flavonol glycoside accumulation in tomatoes. Furthermore, assessments of natural variation combined with functional analyses identified SlDOG1 as a major determinant of tomato SGA content, which also promoted SA and SGA accumulation via the regulation of GAME gene expression. This study provides new insights into the regulatory mechanisms underlying SGA production in tomatoes.

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de Souza, Aloa Machado, Lucienne da Silva Lara, Jose Osvaldo Previato, Aníbal Gil Lopes, Celso Caruso-Neves, Bernadete Pereira da Silva, and José Paz Parente. "Modulation of Sodium Pumps by Steroidal Saponins." Zeitschrift für Naturforschung C 59, no. 5-6 (June 1, 2004): 432–36. http://dx.doi.org/10.1515/znc-2004-5-626.

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Costus spicatus, used in Brazilian traditional medicine to expel kidney stones, contains steroidal saponins with different chemical characteristics. In spite of its popular utilization as potent diuretic, no scientific reports correlate this activity with the chemical constituents of the extract. Therefore, two steroidal saponins (3β,22a,25R)-26-(β-ᴅ-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-ᴅ-apio-β-ᴅ-furanosyl-(1→2)-O-[6-deoxy-α-ʟ-mannopyranosyl- (1→4)]-β-ᴅ-glucopyranoside (1) and (3β,22α,25R)-spirostan-3-yl O-ᴅ-apio-β-ᴅ-furanosyl- (1→2)-O-[6-deoxy-α-ʟ-mannopyranosyl-(1→4)]-β-ᴅ-glucopyranoside (la), were isolated from the rhizomes of this plant and their effects on the Na+-ATPase and (Na++K+)-ATPase activities of the proximal tubule from pig kidney were evaluated. It was observed that 1 and la inhibit specifically the Na+-ATPase activity.

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Zhou, Yuan-Ming, Chang-Lun Shao, Chang-Yun Wang, Hui Huang, Ying Xu, and Pei-Yuan Qian. "Chemical Constituents of the Gorgonian Dichotella fragilis (Ridleg) from the South China Sea." Natural Product Communications 6, no. 9 (September 2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600907.

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Two new steroidal glycosides, fragilioside A (1) and fragilioside B (2), along with five known compounds (3–7) were isolated from the gorgonian Dichotella fragilis (Ridleg) collected from the South China Sea. The structures of the new compounds (1 and 2) were elucidated by comprehensive analysis of spectral data, especially 2D NMR. The brine shrimp lethality and antifouling activity of the isolated compounds were also evaluated.

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Sultana, Shahnaz, Mohammed Ali, and Showkat Rasool Mir. "Chemical Constituents from the Rhizomes of Cyperus Rotundus L." Open Plant Science Journal 10, no. 1 (August 25, 2017): 82–91. http://dx.doi.org/10.2174/1874294701710010082.

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Background: Cyperus rotundus L. (Cyperaceae), is a perennial sedge distributed throughout India and other parts of the world. Its tubers are used as an appetizer, febrifuge and to treat bleeding, blisters, boils, cough, diarrhea, inflammation, lacteal disorders, rheumatoid arthritis, stomach ailments, skin rashes, thirst, vomiting, worm infestation and wounds. Objective: Our study was planned to isolate chemical constituents from the rhizomes of C. rotundus and to characterized their structures. Method: The air-dried rhizome powder was exhaustively extracted with methanol in a Soxhlet apparatus. The concentrated methanol extract was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol, successively, in order of increasing polarity to isolate the compounds. Results: Phytochemical investigation of the tubers led to isolate a sesquiterpenone characterized as 12-methyl cyprot-3-en-2-one-13-oic acid (1), two aliphatic ketone viz. n-dotriacontan-15-one (2) and n-tetracontan-7-one (8), fatty esters n-pentadecanyl octadec-9, 12- dienoate (n-pentadecanyl linoleate, 3), n-hexadecanyl linoleate (4), n-hexadecanyl oleate (5) and n-pentacos-13ʹ-enyl octadec-9-enoate (n-pentacos-13ʹ-enyl oleate, 9), two steroidal esters stigmast-5,22–dien-3β –olyl n-dodecanoate (stigmasterol laurate, 6) and stigmast-5, 22-dien-3β-olyl n-tetradecanoate (stigmasterol myristate, 7), β-sitosterol-3β-O-glucoside (10) and a triterpenic glycosidic ester lup-12, 20 (29)-dien-3β-ol-3-α-L-arabinopyranosyl-2'-oleate (lupenyl 3β-O-arabinpyranosyl 2′-oleate, 11). The structures of these compounds were established by spectral data analysis and chemical reactions. Conclusion: A sesquiterpene identified as cyprot-3-en-2-one-14-oic acid, two aliphatic ketones, fatty esters, two steroidal esters, β-sitosterol-3β-O-glucoside and lupenyl 3β-O-arabinpyranosyl 2′-oleate were isolated for the first time from the rhizomes.

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Aung, Tin Thu Thu, Meng-Yuan Xia, Pyae Phyo Hein, Rong Tang, Dong-Dong Zhang, Jun Yang, Xue-Fei Yang, Dong-Bao Hu, and Yue-Hu Wang. "Chemical Constituents from the Whole Plant of Cuscuta reflexa." Natural Products and Bioprospecting 10, no. 5 (September 21, 2020): 337–44. http://dx.doi.org/10.1007/s13659-020-00265-x.

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Abstract Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-β-sitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4–15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA. Graphic Abstract

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Aeri, Vidhu, Perwez Alam, Mohammed Ali, and Kamran J. Naquvi. "Lupene-type triterpenic and steroidal constituents from the roots of Streblus asper Lour." Journal of Scientific and Innovative Research 4, no. 3 (June 25, 2015): 142–45. http://dx.doi.org/10.31254/jsir.2015.4307.

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Streblus asper Lour. (Moraceae)is a small tree found in tropical regions of the world and used for the treatment of fever, diarrhea, dysentery, elephantiasis, filariasis, gingivitis, leprosy, piles, skin diseases, toothache and wounds.Phytochemical investigation of a methanol extract of the roots led to the isolation of two new compounds characterized as lup-20(29)-en-3β-olyl octadec-9′-enoate (1) and stigmast-5-en-3β-olyl-26-oic acid-3β-hexadecanoate (4) together with the four known constituents identified as lupeol linoleate (2), stigmasterol palmitate (3), cerotic acid (5) and octacosanoic acid (6). The structures of all these compounds were elucidated on the basis spectral data analysis and chemical reactions.

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