Dissertations / Theses on the topic 'Steroid receptors'
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Malouitre, Sylvanie DeÌsireÌe Marie. "Glucocorticoid receptor function, interactions with oestrogen receptors and a steroid inhibitor." Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413737.
Full textBrady, P. "A thermodynamic approach to steroid-based receptors." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596861.
Full textHazell, Georgina Grace Joan. "Deorphanising G protein-coupled receptors : the search for fast steroid receptors." Thesis, University of Bristol, 2011. http://hdl.handle.net/1983/12fbf473-f360-4831-8123-42698aff4950.
Full textFischer, Katharina. "The mineralocorticoid receptor amino terminal transactivation domain investigation of structural plasticity and protein-protein interactions /." Thesis, Available from the University of Aberdeen Library & Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24694.
Full textTitle from web page (viewed on Feb. 23, 2009). With: Natural disordered sequences in the amino terminal domain of nuclear receptors : lessons from the androgen and glucocorticoid receptors / Iain J. McEwan ... et al. Nuclear Receptor Signalling. 2007: 5. Includes bibliographical references.
Nawaz, Zafar. "Molecular Mechanism of Action of Steroid Hormone Receptors." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc798398/.
Full textSmith, Robert A. "The Role of the Steroid Nuclear Receptor Genes in Breast Cancer." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/365401.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Full Text
Judd, Luke William. "Cholapods and cholaphanes : steroid based receptors for anion transport." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544424.
Full textCziko, Paul. "Molecular Physiological Evolution: Steroid Hormone Receptors and Antifreeze Proteins." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/18733.
Full text2017-01-14
Shatnawi, Aymen Ahmad. "New Mechanisms of Transcriptional Regulation of the Folate Receptor and other genes by steroid Receptors." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1201810595.
Full textAyling, Alan J. "Steroidal electroneutral receptors for anions : synthesis and evaluation." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367663.
Full textScheres, Hubertus Maria Elisabeth. "Immunocytochemical and radiochemical determination of steroid receptors in breast cancer." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5469.
Full textBoman, Karin. "Endometrial carcinoma : steroid hormones and receptors in relation to proliferation." Doctoral thesis, Umeå universitet, Onkologi, 1993. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100588.
Full textDiss. (sammanfattning) Umeå : Umeå universitet, 1993, härtill 5 uppsatser.
digitalisering@umu
Clarkson, Alison Marie. "Maternal recognition of pregnancy and steroid receptors in ovine endometrium." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267152.
Full textRiedner, Jens. "Towards a second generation of steroid-derived enantioselective carboxylate receptors." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390650.
Full textRerra, Anna-Isavella. "Genome-wide analyses of signaling pathways controlled by steroid receptors." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ059.
Full textAndrogens (ADs) and glucocorticoids (GCs) are steroid hormones exerting pleiotropic effects in mammals. Their effects are mediated by two nuclear receptors, the androgen (AR) and the glucocorticoid (GR) receptor, respectively. Although GCs are extensively used to treat inflammatory diseases and antiandrogens for prostate cancer, long-term treatments induce major side effects such as muscle atrophy.To determine the mechanisms underlying their effects in muscle, we performed phenotypic, transcriptomic and cistromic analyses. The first part of this work demonstrates that myofiber GR negatively controls muscle mass and strength under physiological GCs levels. GR loss in skeletal muscle did not affect catabolic pathways, but enhanced the expression of anabolic factors and reduced that of anti-anabolic ones. We also showed that myofiber GR binds DNA to GR response elements (GREs) located at enhancers, in association with Myod1 and Foxf2, and interact with promoter-bound factors such as Nrf1 to promote gene transcription.In the second part of this work, we compared GR cistromes and transcriptomes in prostate and skeletal muscle, and identified binding sites for additional transcription factors in the vicinity of GREs, indicating that they contribute to the tissue specificity. In addition, by comparing the AR and GR cistromes and transcriptomes in prostate, we show that the response elements bound by both receptors are distinct from those bound by either AR or GR, and that the receptor-selectivity depends mostly on the surrounding factors.Finally, we compared transcriptomic and epigenetic data of skeletal muscle tissue and C2C12 myoblasts and myotubes and provide a detailed description of genes, signaling pathways and transcription factors that are differentially expressed during myogenic differentiation.In conclusion, our work allowed to clarify the molecular mechanisms regulating muscle homeostasis and provides the basis of a molecular understanding of tissue- and/or promoter-specific activity of ADs and GCs
Hazra, Rasmani. "Sertoli cell steroid nuclear receptors in testis development and function." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/10504.
Full textWacker, Douglas W. "Steroid regulation of seasonal territorial aggression in the male song sparrow, Melospiza melodia morphna /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10625.
Full textCluning, Carmel. "Steroid receptor-associated immunophilins : influence of targeted knockdown and altered expression on receptor signalling." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0215.
Full textDahmoun, Marju. "Apoptosis, proliferation, and sex steroid receptors in endometrium and endometrial carcinoma." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112.
Full textChen, Junling. "Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/34980.
Full textALLEGRETTO, ELIZABETH ANNE. "STRUCTURE - FUNCTION RELATIONSHIPS OF THE VITAMIN D HORMONE RECEPTOR." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184182.
Full textMANGELSDORF, DAVID JOHN. "MOLECULAR BIOLOGY AND ACTIONS OF THE VITAMIN-D HORMONE RECEPTOR." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184218.
Full textHébert-Losier, Andréa 1983. "Structural and functional characterization of a novel endogenous steroid, estradienolone (ED), in human pregnancy." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116111.
Full textRuda, Marcus. "Design and synthesis of steroid mimetic libraries using solid phase techniques /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-049-4/.
Full textIldgruben, Anna. "Human vaginal epithelial immunity and influences of hormonal contraceptive usage." Doctoral thesis, Umeå : Klinisk mikrobiologi, enh. för Immunologi och Klin. vetenskap, obstetrik och gynekologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-595.
Full textTrout, Amanda L. "SEX DIFFERENCES IN CELL DEATH AND STEROID HORMONE RECEPTORS IN CORTICAL EXPLANTS." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/6.
Full textPursell, Natalie W. "Hsp90-Mediated Maturation of Kinases and Nuclear Steroid Hormone Receptors: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/535.
Full text陳家文 and Ka-man Chan. "Molecular cloning and characterization of two cDNAs encoding for two forms of FTZ-F1 in the sand shrimp, Metapenaeus ensis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31220381.
Full textMcCarrick, Jessica Anne. "Differential Regulation of Steroid Receptors in Breast Cancer by the Rho GEF Vav3." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_theses/124.
Full textMaitra, Rajatavo. "Neuroactive steroid modulation of human GABA[subscript]A receptors expressed in Xenopus oocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0006/NQ38316.pdf.
Full textVarshochi, Rana. "Steroid receptors and cell proliferation : cross-talk with the PI3K/Akt signalling pathway." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441958.
Full textBelle, Mino David Charles. "Central expression of sex steroid receptors during the ring dove (Streptopeliarisoria) breeding cycle." Thesis, University of Central Lancashire, 2002. http://clok.uclan.ac.uk/1750/.
Full textBrown, Heather L. D. "Steroid hormone receptor regulation of neuronal pruning and outgrowth in the Drosophila central nervous system /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5097.
Full textSzymanski, de Toledo Maria Carolina 1982. "Expressão dos receptores de estrógeno, progesterona, andrógeno e HER2 no câncer epitelial de ovário : Expression of estrogen, progesterone, androgen and HER2 receptors in the epithelial ovarian cancer." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310530.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Introdução: o câncer de ovário é comumente diagnosticado em estágios avançados, sendo atualmente a neoplasia ginecológica de maior letalidade. As pesquisas têm direcionado esforços na tentativa de descobrir novos fatores prognósticos e métodos terapêuticos. Muitos trabalhos estudam a expressão dos receptores de esteróides (dentre eles, estrógeno (RE), progesterona (RP) e andrógeno (RA)) e HER2 (receptor estimulador de crescimento epitelial - subtipo 2) como fatores prognósticos e associados à resposta terapêutica, apresentando; entretanto, resultados conflitantes. Até onde conhecemos, não há estudos desta natureza no Brasil. Objetivo: Correlacionar à expressão dos RE, RP, RA e HER2 aos fatores clínico patológicos, ao intervalo livre de doença e à sobrevida nos cânceres epiteliais de ovário. Material e métodos: Este é um estudo observacional de coorte retrospectiva. Foram incluídas 152 mulheres com tumores epiteliais malignos, selecionados através dos prontuários no período de 1993 a 2008, no Centro de Atenção Integral à Saúde da Mulher (CAISM) da Universidade Estadual de Campinas - UNICAMP, São Paulo, Brasil. A avaliação da expressão dos RE [subtipos alfa (RE?) e beta (RE?)], RP, RA e HER2 foram realizadas por imunoistoquímica através da construção de microarranjos de tecidos (TMA). Inicialmente, foi realizada análise uni variada da expressão dos receptores acima quanto à idade, estado menopausal, índice de massa corpórea (IMC), tipo histológico, grau histológico, estadiamento inicial de acordo com a classificação proposta pela FIGO e presença de doença residual pós-tratamento cirúrgico. Em seguida, as pacientes foram divididas em dois grupos: ausência da expressão de RE?, RP e HER2 (triplo negativo) e positividade para pelo menos um desses receptores (não triplo negativo); e, avaliadas em relação aos critérios clínicos e epidemiológicos acima. Foram, então, realizadas análises multivariadas dos padrões de expressão de RE ? e ?, RP, RA, HER2 e triplo negativo em relação a estes mesmos critérios. Por fim, análise de sobrevida multivariada foi realizada utilizando-se todos os padrões de expressão e os fatores clínicos epidemiológicos estudados. Resultados: Nas análises multivariadas, mostraram-se significativas as seguintes associações: do receptor de estrógeno alfa (ER?) com tumores de grau histológico menos diferenciado (p=0.01); do receptor de progesterona (RP) à obesidade (p= 0.01); do receptor de andrógeno (RA) com tumores do subtipo seroso (p= 0.01); do receptor de HER2 com tumores dos graus histológicos II-III (p=0.02); do subgrupo triplo negativo com tumores de grau histológico menos diferenciado (II-III) (p<0.01). Não houve associação do RE? com nenhum dos fatores estudados. Quanto à análise multivariada de sobrevida livre de doença e sobrevida global; dentre os padrões de expressão de receptores, apenas o RE? esteve associado com melhor sobrevida livre de doença (RR=0.39; 95%CI 0.17 -0.90). Conclusões: A expressão do RE? esteve mais significativamente associada a fatores clínicos de pior prognóstico. O RP esteve associado à obesidade. O RA esteve significativamente mais presente nos tumores serosos. A expressão do HER2 e a presença de tumores triplo negativo foram maiores em tumores menos diferenciados. Paradoxalmente; o RE? foi o único receptor a apresentar associação com maior sobrevida livre de doença apesar de sua relação significativa com fatores reconhecidos de pior evolução clínica. Não houve diferença estatística significativa na análise multivariada de sobrevida total e sobrevida livre de doença quanto ao grupo de tumores triplo negativo
Abstract: Introduction: Ovarian cancer is commonly diagnosed in advanced stages and currently is the most lethal gynecological malignancy. Surveys have focused efforts in an attempt to discover new prognostic and therapeutic methods. A plenty of studies investigates the expression of steroid receptors (among them, estrogen (ER), progesterone (PR) and androgen AR)) and HER2 (epidermal growth receptor stimulator - subtype 2) as prognostic factors and associated to therapeutic response, presenting, however, conflicting results. As far as we know, there are no studies of this nature in Brazil. Objective: The aim of this study was to correlate the expression of ER (subtypes ? (ER ?) and ? (ER ?), PR, AR and HER2 to clinical pathological factors, the disease-free survival and overall survival of epithelial ovarian cancers. Methods: This is a retrospective observational cohort study. The study included 152 women with malignant epithelial tumors, selected through the records from 1993 to 2008, in the Centro de Atenção Integral à Saúde da Mulher (CAISM) at the State University of Campinas - UNICAMP, São Paulo, Brazil. The expression of ER (? and ?), PR, AR and HER2 was evaluated by immuno histochemistry through tissue microarray (TMA) technique. Initially, univariate analyses were performed, evaluating the expression of each receptor mentioned above to age, menopausal status, body mass index (BMI), histological type, histological grade, initial staging as preconized by FIGO staging of ovarian tumors and presence of residual disease after surgical treatment. Then, the patients were divided into two groups: absence of the expression of ER?, PR and HER2 (triple negative) and positive for at least one of these receptors (not triple negative), and evaluated in relation to the clinical and epidemiological criteria mentioned above. Multivariate analyzes were performed with ER ?, ER?, PR, AR, HER2 and triple negative towards these same criteria. At last, multivariate survival analyses were conducted using all the patterns of receptors' expression, epidemiological and clinical factors studied. Results: In multivariate analyzes, there were the following significant associations: of the estrogen receptor alpha (ER?) with less differentiated histological grade tumors (p = 0.01); of the progesterone receptor (PR) to obesity (p = 0.01); of the androgen receptor (AR) with the serous tumors (p = 0.01); of the HER2 receptor with tumors of histological grades II-III ( p = 0.02); of the triple negative subgroup with less differentiated histological grade tumors (II-III) (p <0.01). There was no association of the ER? with any of the factors studied. In the multivariate analysis of disease-free survival and overall survival; considering the patterns of receptors' expression, only the ER? expression was associated with better disease-free survival (RR= 0.39, 95% CI 0.17 to 0.90). Conclusions: The expression of ER? was more significantly associated with clinical factors of poor prognosis. The PR was associated with obesity. The AR was significantly more prevalent in serous tumors. The HER2 expression and the presence of triple negative epithelial ovarian cancer tumors were higher in less differentiated tumors. Paradoxically, the ER? was the only receptor which showed association with better disease-free survival despite its significant relationship with recognized factors of worse clinical outcome. There was no statistically significant difference in multivariate analysis of overall survival and disease-free survival regarding to the triple negative group
Mestrado
Oncologia Ginecológica e Mamária
Mestra em Ciências da Saúde
Humphries, Karin Hartmann. "Steroid hormone receptors and plasminogen activator in human breast cancer : their value in prognosis." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25888.
Full textMedicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
Guo, Wei-Xing. "Regulation of AIDS-related Kaposi's sarcoma cell proliferation by steroid/retinoid and their receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ38804.pdf.
Full textPatki, Mugdha. "Novel Actions of Steroid Receptors that Limit Treatment Response in Breast and Lung Cancers." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1382094235.
Full textFlood, Lars. "Glucocorticosteroid therapy and steroid resistance in inflammatory bowel disease /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-020-6/.
Full textEnglund, Katarina. "Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4706-6/.
Full textDurham, B. H. "A study of the protamine precipitable cytoplasmic female sex-steroid receptors in human endometrial tissue." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373778.
Full textBenz, David James. "Estrogenic and androgenic regulation of human osteoblast-like cells is mediated by specific steroid receptors." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185442.
Full textChuffa, Luiz Gustavo de Almeida 1982. "Ação da melatonina sobre os receptores esteróides sexuais no ovário, oviduto e útero e o estresse oxidativo nos ovários de ratas adultas UChB (consumidoras voluntárias de etanol a 10%) durante a ovulação." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317529.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O alcoolismo crônico está associado a distúrbios no sistema reprodutor feminino como disfunção hormonal, alteração na expressão dos receptores esteróides, produção de espécies reativas de oxigênio (ERO), entre outros. A melatonina, hormônio secretado pela glândula pineal, possui função moduladora no ciclo reprodutivo e têm papel importante no combate as ERO. Os estudos envolvendo o alcoolismo crônico e sua interação com a melatonina, em fêmeas, são ainda inconclusivos. O presente trabalho tem como objetivo investigar os efeitos da administração exógena da melatonina sobre os hormônios sexuais, os receptores esteróides sexuais (AR, ER-?, ER-?, PRA e PRB) no ovário, oviduto e útero, além do perfil nutricional e o estresse oxidativo nos ovários de ratas adultas UChB (consumidoras voluntárias de etanol a 10%). Foram utilizadas 60 ratas UChB, distribuídas nos seguintes grupos: UChB Co: sem acesso ao etanol; UChB EtOH: consumo diário de 4 - 5 g etanol/100g de peso corpóreo (PC), ambos recebendo solução veículo. Concomitantemente, os grupos UChB Co+M e UChB EtOH+M receberam injeções diárias de melatonina (100?g/100g PC) via i.p, a partir dos 90 dias de idade, durante 60 dias consecutivos. Aos 150 dias de idade, os animais foram eutanasiados em estro (4a.m) e os materiais coletados e processados. A melatonina aumentou os níveis de progesterona, 6-sulfatoximelatonina e reduziu 17?-estradiol, enquanto a combinação entre etanol + melatonina causou uma queda significativa nesses hormônios. Apesar do receptor androgênico (AR) ovariano não ter sido influenciado pela melatonina, os grupos UChB EtOH e UChB EtOH+M mostraram uma diminuição no AR do oviduto. Ambos os receptores de estrogênio (ER-? e ER-?) no oviduto foram pouco expressos em animais recebendo etanol ou melatonina enquanto somente o ER-? uterino foi reduzido. Por outro lado, receptores de progesterona (PRA e PRB) foram positivamente regulados no ovário por etanol ou etanol + melatonina, enquanto PRA foi negativamente regulado no útero e oviduto, exceto quando o etanol e melatonina foram combinados. Os níveis do receptor de melatonina (MT1R) foram maiores no ovário e útero de ratas tratadas com melatonina, independentemente do consumo de etanol. O peso corpóreo dos animais foi reduzido após interação do etanol e melatonina após 40 dias de tratamento. Em ambos os grupos tratados com melatonina, observou-se redução no consumo energético e líquido. Houve diminuição da quantidade de etanol consumida durante o tratamento e o ciclo estral foi maior em ratas que receberam etanol e melatonina, evidenciado por diestro prolongado. Os níveis de hidroperóxido de lipídio foram maiores nos ovários de ratas UChB EtOH e diminuiu após o tratamento com melatonina. Atividades antioxidantes da superóxido dismutase, glutationa peroxidase e glutationa redutase foram aumentadas nos grupos tratados com melatonina. Conclui-se que a melatonina tem efeito oposto ao etanol sobre os hormônios sexuais. Melatonina e etanol regulam diferencialmente os receptores de esteróides sexuais nos tecidos reprodutivos, atuando principalmente através de seu receptor MT1R. Além disso, a melatonina é capaz de alterar a eficiência alimentar, o ciclo estral, e, contudo, protege os ovários contra o estresse oxidativo resultante do consumo de etanol
Abstract: Chronic ethanol intake is associated with female reproductive disturbances including hormonal dysfunction, changes in the steroid receptors expression, production of reactive oxygen species (ROS), among others. Melatonin, an indolamine secreted by pineal gland, plays key roles in the reproductive cycle, besides having an important function in scavenging ROS. Studies focusing chronic alcoholism and its interaction with melatonin, in females, are still inconclusive. This study aims to investigate the effects of exogenous melatonin administration on sex hormones, sex steroid receptors (AR, ER-?, ER-?, PRA and PRB) in the ovary, oviduct and uterus, as well as the nutritional profile and oxidative stress in the ovaries of adult UChB rats (10% (v/v) ethanol voluntary intake). 60 UChB female rats were divided into the following groups: UChB Co: without access to ethanol (used as control); UChB EtOH: drinking daily ethanol at 4 - 5 g ethanol/100g body weight (BW), both receiving vehicle solution. Concomitantly, UChB Co + M and UChB EtOH + M groups received daily injections of melatonin (100?g/100g BW) via i.p, starting from 90 days old and during the next 60 consecutive days. At 150 days of age, all animals were euthanized in estrus (4a.m). Melatonin increased progesterone, 6- sulfatoximelatonin and decreased 17?-estradiol, while the ethanol+melatonin combination caused a significant fall in these hormones. Despite androgen receptor (AR) in ovary has not been influenced by melatonin, ethanol and ethanol+melatonin led to a decrease in oviduct AR. Both estrogen receptors (ER-? and ER-?) were underexpressed by either ethanol or melatonin in oviduct and only uterine ER-? was downregulated. Conversely, progesterone receptors (PRA and PRB) were positively regulated in the ovary by ethanol or ethanol+melatonin, whereas PRA was downregulated in uterus and oviduct, except when ethanol+melatonin were combined. Additionally, melatonin receptor (MT1R) was increased in ovary and uterus of melatonin-treated rats, regardless of ethanol consumption. Body weight gain was reduced with ethanol plus melatonin after 40 days of treatment. In both melatonin-treated groups, it was observed a reduction in food-derived calories and liquid intake toward the end of treatment. The amount of consumed ethanol dropped during the treatment. Estrous cycle was longer in rats that received both ethanol and melatonin, with prolonged diestrus. Following to oxidative status, lipid hydroperoxide levels were higher in the ovaries of ethanol-preferring rats and decreased after melatonin treatment. Additionally, antioxidant activities of superoxide dismutase, glutathione peroxidase and glutathione reductase were increased in melatonin-treated groups . We conclude that melatonin has opposite effect on sex hormones to those of ethanol consumption. Together, melatonin and ethanol differentially regulates the sex steroid receptors in the reproductive tissues, mostly acting "in situ" through its MT1R receptor. Finally, melatonin is able to affect feed efficiency and, conversely, it protects the ovaries against the oxidative stress arising from ethanol consumption.
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
Fochi, Ricardo Alexandre 1982. "Influência da progesterona sobre a próstata do gerbilo (Meriones unguiculatus) = interações com o estrógeno e com a testosterona = Progesterone influence on gerbil (Meriones unguiculatus) prostat e: interactions with estrogen and testosterone." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317913.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: A próstata, glândula do sistema genital que tem origem embrionária a partir do seio urogenital, não é exclusiva do sistema reprodutor masculino, sendo também encontrada em fêmeas de vários mamíferos, incluindo humanos e roedores. No macho ela pode apresentar-se altamente desenvolvida em razão da maior quantidade do hormônio testosterona, e, apesar de pouco desenvolvida em fêmeas, devido à baixa quantidade desse mesmo tipo hormonal, é uma glândula funcional. Em fêmeas adultas de gerbilos, a próstata possui uma localização parauretral, exibindo íntimo contato com a parede proximal e medial da uretra, a qual é homóloga a próstata ventral de roedores machos. Embora se conheça a influência da progesterona na fisiologia do sistema reprodutor feminino e masculino, poucos estudos exploram a sua influência, especificamente, sobre a glândula prostática. Desta forma, este trabalho avaliou os aspectos morfofuncionais da glândula prostática masculina e feminina, resultantes da influência da progesterona, e de suas interações com o estradiol e a testosterona. Para isso, gerbilos machos e fêmeas foram castrados cirurgicamente no início do período puberal, aos 45 dias de idade. Ao completarem 90 dias de idade, os gerbilos receberam doses subcutâneas de progesterona ou desse somado a estradiol e testosterona, durante 14 dias. Nos animais castrados de ambos os sexos a próstata mostrou uma morfologia regredida, com uma redução significativa na sua capacidade de secreção, da quantidade de células receptoras de androgênio (AR) e receptoras de estrógeno ? (ER?), porém sem alterar a marcação para receptor de estrógeno ? (ER?). Dessa forma, a castração cirúrgica foi bastante importante, uma vez que permitiu mimetizar de forma satisfatória um ambiente prostático com baixos níveis hormonais. Nos dois sexos, a administração de progesterona isoladamente conseguiu reverter alguns desses efeitos, com uma melhora considerável no padrão secretório da glândula, porém estruturalmente essas mudanças ocorreram de forma moderada. Nesses animais, foi observado um aumento expressivo dos ERs ? e ?, além da presença de células receptoras de progesterona (PR). Em relação aos ARs foi evidenciado que a progesterona pode apresentar características indutoras ou inibitórias dependendo da sua concentração. O tratamento, simultâneo com a progesterona, de estradiol e testosterona desencadeou uma reestruturação glandular mais intensa nos machos e fêmeas, resultando em hipertrofia e hiperplasia do epitélio e do estroma glandular, recuperação do padrão de secreção e amplitude alveolar. Essas características, no entanto, foram acompanhadas pelo surgimento de lesões prostáticas como neoplasias intraepiteliais e o surgimento de debris celulares. A interação da progesterona com o estradiol também regulou positivamente os AR, ER? e ER?, porém não apresentou qualquer efeito sobre os PRs quando comparado aos animais tratados somente com progesterona. Em adição, nesses animais houve um aumento acentuado da proliferação celular, o qual foi contrabalanceado pelo aumento também do índice de morte celular. Nos animais tratados com progesterona e testosterona, a próstata também se desenvolveu e mostrou um aumento das células AR-positivas e do índice apoptótico, havendo, entretanto uma redução dos ER?, ER? e PR. Dessa forma, é razoável concluir que a próstata feminina e masculina comporta-se de forma bastante semelhante frente à ação dos hormônios progesterona, estradiol e testosterona. Ademais, embora a progesterona apresente efeitos estruturais razoáveis na glândula prostática, a sua interação com o estrógeno e a testosterona é capaz de promover uma intensificação desses efeitos, sem recriar, porém um ambiente homeostático semelhante aos dos animais intactos. A progesterona também mostrou ser um fator regulador em potencial da atividade proliferativa e apoptótica prostática, opondo-se aos efeitos da testosterona e do estradiol. Outro fator importante é a descoberta de que a progesterona pode induzir ou inibir a presença de células AR-positivas na glândula, e que esse dualismo funcional é resultado do efeito dose-dependente desse hormônio sobre a próstata
Abstract: The prostate is a gland of reproductive system that arises from the urogenital sinus, being located around the urethra below the bladder. The existence of this gland is not exclusive of the male reproductive system, being found in females of various species, including rodents and humans. In the male, it can be highly developed due to the increased amount of the testosterone, and although poorly developed in females, due to the low quantity of this hormone, it is a functional gland. The prostate of female gerbils has a paraurethral location, showing a closer contact with the proximal and medial urethra wall, being homologous to the ventral prostate of male rats. This study evaluates the morphofunctional aspects of the prostate gland in males and females, regarding the influence of progesterone, and their interactions with estradiol and testosterone. For this, male and female gerbils were surgically castrated in early pubertal period, at 45 days of age. At 90 days of age, the gerbils received subcutaneous doses of progesterone alone or associated to testosterone or estradiol during 14 days. In castrated animals of both sexes, prostate showed a regressed morphology, with a significant reduction in its secretion capacity, the amount of androgen receptor cells (AR) and estrogen receptor ? (ER?), but without changing the labeling for estrogen receptor ? (ER?). Thereby, surgical castration was very important, since it allowed mimetize a prostatic environment with low hormone levels. In both sexes, the administration of progesterone alone could reverse some of these effects with a considerable secretion improvement, but structurally these changes occurred in a moderate way. In these animals, we observed a significant increase of ER ? and ?, besides the presence of progesterone receptor (PR) cells. Regarding ARs, it was shown that progesterone can have inductor or inhibitory characteristics depending on its concentration. The treatment with progesterone plus estradiol and progesterone plus testosterone triggered a more intense prostate restructuration in male and female, resulting however in a hypertrophy and hyperplasia of the glandular epithelium and stroma, besides recovery of the alveoli amplitude and pattern of cellular secretion. These characteristics, however, were followed by the development of prostatic lesions like intraepithelial neoplasia and cellular desquamation. The progesterone and estradiol interaction also upregulated the AR, ER? and ER?, however had no effect on the PRs when compared to the animals treated with progesterone alone. In addition, in these animals there was a marked increase in cellular proliferation, which was counterbalanced by increased cell death. In animals of either sex treated with progesterone and testosterone, the prostate also became developed and showed an increase of AR-positive cells and apoptotic index, although there was a reduction of ER?, ER? and PR. Thus, it is reasonable to conclude that the female and male prostate behaves similarly after the progesterone, estradiol and testosterone administration. Moreover, although the progesterone has reasonable structural effects on the prostate gland, its interaction with estrogen and testosterone can intensificate these effects, but do not recover a homeostatic environment similar to that of intact animals. The progesterone also proved to be a potential regulatory factor of the proliferative and apoptotic activity, opposing the effects of testosterone and estradiol. Another important finding is that progesterone can induce or inhibit the presence of ARpositive cells in the gland, and this functional dualism is the result of dose-dependent effect of this hormone on the prostate
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
Brito, Claudia Prado de. "Avaliação imunoistoquímica dos receptores de estrógeno e progesterona no tumor venéreo transmissível (TVT) e tecido vaginal de cadelas portadoras e hígidas em diferentes fases do ciclo estral." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-18102004-105856/.
Full textOne of the most frequent canine neoplasias is the Transmissible Venereal Tumour (TVT) which affects male and female genital tract. In clinical routine the standard treatment is chemotherapy, to which nevertheless drug resistance is a common feature. Immunohistochemical determination of steroid hormone receptors (estrogen and progesterone) in normal and tumoral tissues of humans and several other species is of great relevance for prognostic evaluation of oncological patients, as well as for the decision of whether to make use of hormonal therapy in association to chemotherapy. The aim of this research was to determine immunohistochemically estrogen (ER-α) and progesterone (PR4) receptors expression in vaginal tissue of non-affected bitches and in vaginal and tumoral tissues of TVT affected bitches. Fifty-eight bitches were equally divided in 2 groups: experimental group (TVT) and control group (non-affected). Canine estrous cycle phases were determined by means of vaginal cytology, hormonal assay and macroscopic appearance of ovaries. Samples from vaginal and tumoral tissues were obtained with bitches submitted to general anesthesia. Samples were fixed in 10% buffered formaldehyde and then mounted in paraffin-embedded sections. Anestrous, proestrous and estrous control females presented higher ER-α expression than diestrous bitches. Within the experimental group, there was statistical difference between estrous and diestrous phases, being ER-α expression higher for diestrous bitches. However, no significant difference in relation to anestrous females was established. In relation to RP4 expression, no difference among estrous cycle phases of the control group was verified. Furthermore, no RP4 expression was noted in vaginal tissue of TVT affected females. In tumoral tissues ER-α and RP4 were not expressed, although some samples presented ER-α expression in blood vessels endothelium. In conclusion, different ER-α expression was verified in vaginal tissue of experimental and control bitches under distinct steroid influence, whereas no ER-α expression in tumoral tissues was evidenced
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