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Relevant bibliographies by topics / Steroid hormones

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Academic literature on the topic 'Steroid hormones'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 July 2024

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Journal articles on the topic "Steroid hormones"

1

Karashima, Shigehiro, and Issey Osaka. "Rapidity and Precision of Steroid Hormone Measurement." Journal of Clinical Medicine 11, no. 4 (February 12, 2022): 956. http://dx.doi.org/10.3390/jcm11040956.

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Steroids are present in all animals and plants, from mammals to prokaryotes. In the medical field, steroids are commonly classified as glucocorticoids, mineralocorticoids, and gonadal steroid hormones. Monitoring of hormones is useful in clinical and research fields for the assessment of physiological changes associated with aging, disease risk, and the diagnostic and therapeutic effects of various diseases. Since the discovery and isolation of steroid hormones, measurement methods for steroid hormones in biological samples have advanced substantially. Although immunoassays (IAs) are widely used in daily practice, mass spectrometry (MS)-based methods have been reported to be more specific. Steroid hormone measurement based on MS is desirable in clinical practice; however, there are several drawbacks, including the purchase and maintenance costs of the MS instrument and the need for specialized training of technicians. In this review, we discuss IA- and MS-based methods currently in use and briefly present the history of steroid hormone measurement. In addition, we describe recent advances in IA- and MS-based methods and future applications and considerations.

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BLAND, Rosemary. "Steroid hormone receptor expression and action in bone." Clinical Science 98, no. 2 (January 31, 2000): 217–40. http://dx.doi.org/10.1042/cs0980217.

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The skeleton is a complex tissue, and hormonal control of bone remodelling is elaborate. The important role that steroid hormones play in bone cell development and in the maintenance of normal bone architecture is well established, but it is only relatively recently that it has become possible to describe their precise mechanism of action. This review focuses not only on the steroid hormones (oestrogens, corticosteroids, androgens and progesterone), but also on related hormones (vitamin D, thyroid hormone and the retinoids), all of which act via structurally homologous nuclear receptors that form part of the steroid/thyroid receptor superfamily. By examining the actions of all of these hormones in vivo and in vitro, this review gives a general overview of the current understanding of steroid hormone action in bone. In addition, a comprehensive review of steroid hormone receptor expression in bone cells is included. Finally, the role that future developments, such as steroid hormone receptor knockout mice, will play in our understanding of steroid hormone action in bone is considered.

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Shore, L. S., and M. Shemesh. "Naturally produced steroid hormones and their release into the environment." Pure and Applied Chemistry 75, no. 11-12 (January 1, 2003): 1859–71. http://dx.doi.org/10.1351/pac200375111859.

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Steroidal hormones produced by humans and animals are constantly excreted into the environment in their active forms. The primary steroid hormones are progesterone, estrone, estradiol, testosterone, and cortisol, all of which are lipophilic and poorly soluble in water. The steroids of major concern are estrone and estradiol-17β, since they exert their physiological effects at a lower concentration than other steroids and can be found in the environment in concentrations above their LOEL for fish and plants (10 ng/l). The steroid hormones can be readily measured in run-off, soil, and groundwater, but each steroid has its distinct pathway of transport. Since the major source of steroids in the environment appears to be cattle and chickens, the hormonal steroid input into the environment could be drastically reduced by well-established techniques such as buffer strips and composting.

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Szczepanska-Sadowska, Ewa, Katarzyna Czarzasta, Wiktor Bogacki-Rychlik, and Michał Kowara. "The Interaction of Vasopressin with Hormones of the Hypothalamo–Pituitary–Adrenal Axis: The Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases." International Journal of Molecular Sciences 25, no. 13 (July 5, 2024): 7394. http://dx.doi.org/10.3390/ijms25137394.

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A large body of evidence indicates that vasopressin (AVP) and steroid hormones are frequently secreted together and closely cooperate in the regulation of blood pressure, metabolism, water–electrolyte balance, and behavior, thereby securing survival and the comfort of life. Vasopressin cooperates with hormones of the hypothalamo–pituitary–adrenal axis (HPA) at several levels through regulation of the release of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and multiple steroid hormones, as well as through interactions with steroids in the target organs. These interactions are facilitated by positive and negative feedback between specific components of the HPA. Altogether, AVP and the HPA cooperate closely as a coordinated functional AVP-HPA system. It has been shown that cooperation between AVP and steroid hormones may be affected by cellular stress combined with hypoxia, and by metabolic, cardiovascular, and respiratory disorders; neurogenic stress; and inflammation. Growing evidence indicates that central and peripheral interactions between AVP and steroid hormones are reprogrammed in cardiovascular and metabolic diseases and that these rearrangements exert either beneficial or harmful effects. The present review highlights specific mechanisms of the interactions between AVP and steroids at cellular and systemic levels and analyses the consequences of the inappropriate cooperation of various components of the AVP-HPA system for the pathogenesis of cardiovascular and metabolic diseases.

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Simoncini, T., and AR Genazzani. "Non-genomic actions of sex steroid hormones." European Journal of Endocrinology 148, no. 3 (March 1, 2003): 281–92. http://dx.doi.org/10.1530/eje.0.1480281.

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Steroid hormone receptors have been traditionally considered to act via the regulation of transcriptional processes, involving nuclear translocation and binding to specific response elements, and ultimately leading to regulation of gene expression. However, novel non-transcriptional mechanisms of signal transduction through steroid hormone receptors have been identified. These so-called 'non-genomic' effects do not depend on gene transcription or protein synthesis and involve steroid-induced modulation of cytoplasmic or cell membrane-bound regulatory proteins. Several relevant biological actions of steroids have been associated with this kind of signaling. Ubiquitous regulatory cascades such as mitogen-activated protein kinases, the phosphatidylinositol 3-OH kinase and tyrosine kinases are modulated through non-transcriptional mechanisms by steroid hormones. Furthermore, steroid hormone receptor modulation of cell membrane-associated molecules such as ion channels and G-protein-coupled receptors has been shown. TIssues traditionally considered as 'non-targets' for classical steroid actions are instead found to be vividly regulated by non-genomic mechanisms. To this aim, the cardiovascular and the central nervous system provide excellent examples, where steroid hormones induce rapid vasodilatation and neuronal survival via non-genomic mechanisms, leading to relevant pathophysiological consequences. The evidence collected in the past Years indicates that target cells and organs are regulated by a complex interplay of genomic and non-genomic signaling mechanisms of steroid hormones, and the integrated action of these machineries has important functional roles in a variety of pathophysiological processes. The understanding of the molecular basis of the rapid effects of steroids is therefore important, and may in the future turn out to be of relevance for clinical purposes.

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He, Jinhan, Qiuqiong Cheng, and Wen Xie. "Minireview: Nuclear Receptor-Controlled Steroid Hormone Synthesis and Metabolism." Molecular Endocrinology 24, no. 1 (January 1, 2010): 11–21. http://dx.doi.org/10.1210/me.2009-0212.

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Abstract Steroid hormones are essential in normal physiology whereas disruptions in hormonal homeostasis represent an important etiological factor for many human diseases. Steroid hormones exert most of their functions through the binding and activation of nuclear hormone receptors (NRs or NHRs), a superfamily of DNA-binding and often ligand-dependent transcription factors. In recent years, accumulating evidence has suggested that NRs can also regulate the biosynthesis and metabolism of steroid hormones. This review will focus on the recent progress in our understanding of the regulatory role of NRs in hormonal homeostasis and the implications of this regulation in physiology and diseases.

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Marcinkowska, Ewa, and Antoni Wiedłocha. "Steroid signal transduction activated at the cell membrane: from plants to animals." Acta Biochimica Polonica 49, no. 3 (September 30, 2002): 735–45. http://dx.doi.org/10.18388/abp.2002_3782.

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Steroid hormones in plants and in animals are very important for physiological and developmental regulation. In animals steroid hormones are recognized by nuclear receptors, which transcriptionally regulate specific target genes following binding of the ligand. In addition, numerous rapid effects generated by steroids appear to be mediated by a mechanism not depending on the activation of nuclear receptors. Although the existence of separate membrane receptors was postulated many years ago and hundreds of reports supporting this hypothesis have been published, no animal membrane steroid receptor has been cloned to date. Meanwhile, a plant steroid receptor from Arabidopsis thaliana has been identified and cloned. It is a transmembrane protein which specifically recognizes plant steroids (brassinosteroids) at the cell surface and has a serine/threonine protein kinase activity. It seems that plants have no intracellular steroid receptors, since there are no genes homologous to the family of animal nuclear steroid receptors in the genome of A. thaliana. Since the reason of the rapid responses to steroid hormones in animal cells still remains obscure we show in this article two possible explanations of this phenomenon. Using 1,25-dihydroxyvitamin D(3) as an example of animal steroid hormone, we review results of our and of other groups concordant with the hypothesis of membrane steroid receptors. We also review the results of experiments performed with ovarian hormones, that led their authors to the hypothesis explaining rapid steroid actions without distinct membrane steroid receptors. Finally, examples of polypeptide growth factor that similarly to steroids exhibit a dual mode of action, activating not only cell surface receptors, but also intracellular targets, are discussed.

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Welch, Kma. "Migraine and ovarian steroid hormones." Cephalalgia 17, no. 20_suppl (December 1997): 12–16. http://dx.doi.org/10.1177/0333102497017s2005.

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This chapter reviews clinical and epidemiological data that support a role for ovarian steroid hormones in the migraine syndrome. Changes in the clinical presentation of migraine are discussed on the basis of current knowledge of biochemistry and pharmacology of ovarian steroids. Finally, special treatment considerations of ovarian hormone-sensitive migraine are discussed.

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Krause, Diana N., Sue P. Duckles, and Dale A. Pelligrino. "Influence of sex steroid hormones on cerebrovascular function." Journal of Applied Physiology 101, no. 4 (October 2006): 1252–61. http://dx.doi.org/10.1152/japplphysiol.01095.2005.

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The cerebral vasculature is a target tissue for sex steroid hormones. Estrogens, androgens, and progestins all influence the function and pathophysiology of the cerebral circulation. Estrogen decreases cerebral vascular tone and increases cerebral blood flow by enhancing endothelial-derived nitric oxide and prostacyclin pathways. Testosterone has opposite effects, increasing cerebral artery tone. Cerebrovascular inflammation is suppressed by estrogen but increased by testosterone and progesterone. Evidence suggests that sex steroids also modulate blood-brain barrier permeability. Estrogen has important protective effects on cerebral endothelial cells by increasing mitochondrial efficiency, decreasing free radical production, promoting cell survival, and stimulating angiogenesis. Although much has been learned regarding hormonal effects on brain blood vessels, most studies involve young, healthy animals. It is becoming apparent that hormonal effects may be modified by aging or disease states such as diabetes. Furthermore, effects of testosterone are complicated because this steroid is also converted to estrogen, systemically and possibly within the vessels themselves. Elucidating the impact of sex steroids on the cerebral vasculature is important for understanding male-female differences in stroke and conditions such as menstrual migraine and preeclampsia-related cerebral edema in pregnancy. Cerebrovascular effects of sex steroids also need to be considered in untangling current controversies regarding consequences of hormone replacement therapies and steroid abuse.

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Mukudai, Shigeyuki, Ken Ichi Matsuda, Takeshi Nishio, Yoichiro Sugiyama, Hideki Bando, Ryuichi Hirota, Hirofumi Sakaguchi, Yasuo Hisa, and Mitsuhiro Kawata. "Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus." Endocrinology 156, no. 3 (March 1, 2015): 1000–1009. http://dx.doi.org/10.1210/en.2014-1605.

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Abstract There is accumulating evidence that fibroblasts are target cells for steroids such as sex hormones and corticoids. The characteristics of fibroblasts vary among tissues and organs. Our aim in this study is to examine differences in responses to steroid hormones among fibroblasts from different cervicothoracic regions. We compared the actions of steroid hormones on cultured fibroblasts from the vocal folds, which are considered to be the primary target of steroid hormones, and the trachea and esophagus in adult male rats. Expression of steroid hormone receptors (androgen receptor, estrogen receptor α, and glucocorticoid receptor) was identified by immunofluorescence histochemistry. Androgen receptor was much more frequently expressed in fibroblasts from the vocal fold than in those from the trachea and esophagus. Cell proliferation analysis showed that administration of testosterone, estradiol, or corticosterone suppressed growth of all 3 types of fibroblasts. However, mRNA expression for extracellular matrix–associated genes, including procollagen I and III and elastin, and hyaluronic acid synthase I was elevated only by addition of testosterone to fibroblasts from the vocal fold. These results indicate that each steroid hormone exerts region-specific effects on cervicothoracic fibroblasts with different properties through binding to specific receptors.

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Dissertations / Theses on the topic "Steroid hormones"

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Lund-Pero, Margaretha. "Nonspecific esterases in human tissues evidence for their involvement in steroid metabolism and in carcinogenesis /." Lund : Dept. of Molecular Ecogenetics, the Wallenberg Laboratory, University of Lund, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39781861.html.

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Seymour, Beverley Lesley. "The effect of steroid hormones on the size of myometrial cells : a morphometric study." Thesis, Cape Technikon, 1997. http://hdl.handle.net/20.500.11838/1503.

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Thesis (MTech (Biomedical Technology))--Cape Technikon, Cape Town,1997
The aims of this study were to measure: 1. Myometrial cells of menopausal uteri to establish whether they atrophy after the menopause. 2. Myometrial cells at different phases of the menstrual cycle to investigate the influences of oestrogen and progesterone during the cycle. 3. Myometrial cells in the fundus and lower uterine segment to establish whether they differ in size. 4. Myometrial cells of pregnant uteri to investigate the effect of the hormonal status of pregnant women on the size of myometrial cells. 5. Neoplastic cells of leiomyomas of the uterus to investigate whether these benign tumours behave in the same manner as myometrium or, because they are neoplastic, they react differently. A preliminary investigation was undertaken to establish the optimal methodology for this study to measure myometrial and leiomyoma nuclei in the uterus. The aims of this preliminary investigation were: 1. To test the reproducibility of measurements of myometrial and leiomyoma nuclei in transverse and cross section. 2. To test five histological staining methods to ascertain the best method for a morphometric study on uterine cells. 3. To find the minimum sample size of nuclei per section of myometrium or leiomyoma in order to yield statistically significant results. This preliminary study found that the Haematoxylin and Eosin stain gave the most statistically reproducible measurements. Subjective assessment of the five staining methods also found Haematoxylin and Eosin to be optimal. It was also found during the preliminary study that measuring the myometrial nuclei in cross rather than transverse section gave the most statistically reproducible measurements. It was also found that it was best to use an axial ratio criterion of 0,9 when measuring cross-sectioned myometrial nuclei. The optimum sample size per section was also investigated and it was found that measuring 100 nuclei was optimal. It was found that in the uteri used in this study there was no statistically significant decrease in nuclear size after the menopause. It was also found that there was no statistically significant difference in nuclear size during the different phases of the menstrual cycle. There was also no notable difference in nuclear size between nuclei in the fundus and lower segment of the uteri in this study. It was found that there was a significant increase in the size of nuclei in leiomyomas compared to the normal myometrial nuclei from the same patient. The myometrial nuclei from pregnant uteri were also significantly larger than those from non-gravid uteri.

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Al-Mana, D. "Ovarian steroid hormones and auditory function." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1386639/.

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Considerable anecdotal evidence and information from previous studies suggest that auditory function may be influenced by hormones. This thesis reviews in detail the potential role of hormones in modulating the auditory system and in the development of pathological conditions in the auditory system with an emphasis on the effect of the ovarian hormones. Ovarian steroids may influence auditory function directly through their receptors, which have been detected in the auditory system, or indirectly through their effects on the blood supply, the fluid electrolyte balance of the cochlea, and the neurotransmitters of the auditory system. Effects on other parts of the central nervous system connected to the auditory system may also be of importance. The aim of the study was to investigate whether physiological alterations in ovarian hormones in women with normal hearing, during the natural ovarian cycle and assisted conception treatment were associated with changes in auditory function at the cochlear and brain stem level, and whether these variations were not seen in men over a similar period of time. The auditory tests evaluated auditory function from the outer ear to the brainstem in both the afferent and efferent system. Hormone levels were assayed only in the female subjects at the same time as the auditory testing, four times during the ovarian cycle, or three times during the assisted conception treatment. Auditory tests were undertaken in the male subjects once a week for four consecutive weeks to correspond with the ovarian cycle measurements. A number of changes in auditory function were observed during the ovarian cycle and assisted conception treatment, and gender differences were noted. The OAE results may suggest either excitation of the cochlea with higher levels of oestrogen, or suppression of the cochlea with higher level of progesterone. The longer ABR latency following ovarian stimulation and in the follicular phase of the ovarian cycle is consistent with the inhibitory effect of neurosteroids on ABR associated with higher levels of oestrogen. The variation in auditory function were not observed in men.

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Farquharson, Roy G. "Fetal abstraction of placental steroid hormones." Thesis, University of Aberdeen, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328653.

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Gingnell, Malin. "Ovarian Steroid Hormones, Emotion Processing and Mood." Doctoral thesis, Uppsala universitet, Obstetrik & gynekologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199791.

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It is known that some psychiatric disorders may deteriorate in relation to the menstrual cycle. However, in some conditions, such as premenstrual dysphoric disorder (PMDD), symptomatology is triggered mainly by the variations in ovarian steroid hormones. Although symptoms induced by fluctuations in ovarian steroids often are affective, little is known about how emotion processing in women is influenced by variations, or actual levels, of ovarian steroid hormones. The general aim of this thesis was to evaluate menstrual cycle effects on reactivity in emotion generating and controlling areas in the corticolimbic system to emotional stimulation and anticipation, in healthy controls and women with PMDD. A second aim was to evaluate corticolimbic reactivity during long-term administration of exogenous ovarian steroids. In study I, III and IV effects of the menstrual cycle on emotional reactivity in women with PMDD was studied. In study I, women with PMDD in displayed higher amygdala reactivity than healthy controls to emotional faces, not in the luteal phase as was hypothesised, but in the follicular phase. No difference between menstrual cycle phases was obtained in women with PMDD, while healthy controls had an increased reactivity in the luteal phase. The results of study I was further elaborated in study III, where women with PMDD were observed to have an increased anticipatory reactivity to negative emotional stimuli. However, no differences in amygdala reactivity to emotional stimuli were obtained across the menstrual cycle. Finally, in study IV the hypothesis that amygdala reactivity increase in the luteal phase in women with PMDD is linked to social stimuli rather than generally arousing stimuli was suggested, tested and supported. In study II, re-exposure to COC induced mood symptoms de novo in women with a previous history of COC-induced adverse mood. Women treated with COC reported increased levels of mood symptoms both as compared to before treatment, and as compared to the placebo group. There was a relatively strong correlation between depressive scores before and during treatment. The effects of repeated COC administration on subjective measures and brain function were however dissociated with increased aversive experiences accompanied by reduced reactivity in the insular cortex.

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Murai, Takahiro. "Study on the diglucuronidation reaction of steroid hormones." Kyoto University, 2008. http://hdl.handle.net/2433/136704.

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Charlton, Michael Hugh. "Theoretical studies of steroid hormones and related compounds." Thesis, University of St Andrews, 1992. http://hdl.handle.net/10023/14449.

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A theoretical study of steroidal inhibitors of the enzymes Glucose-6-Phosphate Dehydrogenase and Aromatase is presented. Both enzyme systems are of interest in the study of cancer, the latter being the final step in the biosynthesis of oestrogens which are involved in certain types of breast cancer. Two levels of theory are employed in the study, namely, Ab Initio and Semi Empirical methods. Structures and charges have been calculated using the MOPAC and GAUSSIAN programs and these have been used to model the efficacy of various inhibitors. The major tool in comparing these steroids has been the molecular electrostatic potential (MEP). Maps of the MEP and an analysis of the similarity between the MEP s of different molecules have led both to a method of assessing the activities of steroids as enzyme inhibitors and requirements for the electronic structure of the steroid binding sites within these enzymes. A molecular graphics display program has been developed to facilitate this work. It has been designed to make full use of the facilities available. The quality of the resulting display has improved greatly on what was previously available and has been of value in studies of large molecular systems. The program is written in VAX FORTRAN and uses the Graphics Kernel System (GKS) to produce graphical output and should be reasonably easy to transfer to other systems. Finally, to determine whether PM3 really is a significant advance on AM1, a comparison of the two semi empirical methods is presented. The calculated properties of steroid hormones are compared to those of both Ab Initio calculations and experimental determinations, allowing the quality of the semi empirical predictions to be assessed.

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Mercurio, S. "ROLE OF STEROID HORMONES IN ECHINOID REPRODUCTIVE BIOLOGY." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/230752.

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Echinoid reproductive cycle has been extensively studied in several species but the mechanisms regulating gametogenesis processes are still scarcely understood. Apart from environmental factors, different research have suggested a steroid role in gonad maturation and growth. Particularly, in echinoderms steroid involvement in reproduction has been suggested by both studies on seasonal changes of steroid levels during the gonadal cycle and experiments of hormone administration. Nevertheless, the steroid function in echinoid reproductive processes has not been clearly identified, probably due to the low number of studies and the big variability of results reported. Thus, the main aim of this research project was to shed light on echinoid endocrinology and, in particular, to clarify the involvement of sex-steroid hormones in sea urchin reproductive biology. This was achieved employing both in vivo and in vitro approaches. First of all, considering the lack of studies on the development of effective cell cultures from echinoderm gonads, primary cell cultures from ovaries of the edible sea urchin Paracentrotus lividus were developed. Ovary cell phenotypes, present in culture, were identified and characterized by different microscopic techniques. Although cell cultures could be produced from ovaries at all stages of maturation, the cells appeared healthier and viable, displaying a higher survival rate, when ovaries at early stages of gametogenesis were used. In terms of culture medium, ovarian cells were successfully cultured in modified Leibovitz-15 medium, whereas poor results were obtained in Minimum Essential Medium Eagle and Medium 199. Different substrates were tested but ovarian cells completely adhered only on poly-L-lysine. To improve in vitro conditions and stimulate cell proliferation different serum-supplements were tested. Fetal Calf Serum and an originally developed Pluteus Extract resulted to be detrimental to cell survival, apparently accelerating processes of cell death. In contrast, cells cultured with sea urchin Egg Extract appeared larger and healthier, displaying an increased longevity that allowed to maintain them for up to 1 month. Overall this study provides new experimental bases and procedures for producing successfully long-term primary cell cultures from sea urchin ovaries, providing a simple and versatile experimental tool for research in echinoderm reproductive biology. Subsequently, in vivo and in vitro experiments, specifically addressed to determine possible 17β-estradiol (E2) and testosterone (T) involvement in echinoid reproduction, were performed. An in vivo long-term experiment of steroid dietary administration was performed in adult specimens of P. lividus. The experimental plan was specifically designed in order to reduce individual variability and synchronize the experimental animals at the same starting maturative condition. We analysed and compared different reproductive parameters (Gonad Index, Maturative Index and maturative stages distribution) in 4 experimental groups: control group (CTL), E2 and T groups fed with pellets containing respectively 17β-estradiol and testosterone, and E2-4 weeks group fed with control pellets for the first 4 weeks and then treated with 17β-estradiol. This latter was chosen in order to verify the existence of a specific E2-sensitive gametogenic stage, as proposed in different asteroid species. Possible steroid effects on P. lividus female reproduction was also investigated with an in vitro approach. Cells, isolated by ovaries in the same maturative conditions considered in the in vivo experiments, were cultured in presence of E2 and T physiological concentrations for 2 weeks. Effects on ovarian cell morphology and behaviour were investigated. In addition, steroid regulation of the Major Yolk Protein (MYP) expression was analyzed 24 and 48 hours after E2 and T exposure. According to our results, E2 and T do not markedly influence echinoid gonad maturation and, particularly, they do not promote gamete maturation. Hormonal dietary administration did not induce striking variations in the considered reproductive parameters and no effect was observed also when males and females were analyzed separately. In addition, no specific maturative stage sensitive to E2 was found, suggesting the existence of different hormonal mechanisms in asteroids and echinoids. Similar considerations could be reported taking into account the in vitro experiments. E2 and T exposure did not affect ovarian cell size and behaviour nor MYP expression. The obtained results suggest that these hormones are not directly involved in either gamete maturation, as demonstrated for vertebrates, or in vitellogenesis processes, as reported for several asteroid species. However a possible involvement of steroids in echinoid physiology cannot be completely excluded and their role in the regulation of lipid metabolism and protein synthesis during the different reproductive stages should be strongly considered as suggested by several authors. Further specific research on steroid hormone mode of action, physiological function and metabolism are therefore needed to completely understand echinoid reproduction and endocrinology.

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Nawaz, Zafar. "Molecular Mechanism of Action of Steroid Hormone Receptors." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc798398/.

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A novel bacterial expression system that is capable of producing high levels of soluble, stable, biologically active human vitamin D3 and estrogen receptors has been developed. The method utilizes ubiquitin fusion technology and a low temperature nalidixic acid induction of the lambda PL promoter. This system can produce large quantities of receptor antigen, but only a small fraction displays wild-type DNA and hormone binding properties. Therefore, the use of this system to overproduce receptors for crystallization studies is not practical. To overcome these problems, a 2 um based ubiquitin fusion system which allows regulated expression of the estrogen receptor in yeast (Saccharomyces cerevisiae) was developed. This system produces the estrogen receptor to a level of 0.2% of the total soluble protein. Moreover, this protein is undegradable, soluble, and biologically active. To test the transcriptional activity of the estrogen receptor produced in yeast, a cis-trans transcription assay was developed. This assay revealed that the transcriptional activity of the human estrogen receptor expressed in yeast was similar to that observed in transfected mammalian cells. This reconstituted estrogen transcription unit in Saccharomyces cerevisiae was utilized to examine the regulation of estrogen receptor functions by antiestrogens, to develop a random and rapid approach for identifying novel estrogen response elements, to characterize estrogen receptor variants cloned from human breast tumors, and to examine the effect of estrogen receptor on the regulation of osteocalcin gene.

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Fischer, Katharina. "The mineralocorticoid receptor amino terminal transactivation domain investigation of structural plasticity and protein-protein interactions /." Thesis, Available from the University of Aberdeen Library & Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24694.

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Thesis (Ph.D.)--Aberdeen University, 2008.
Title from web page (viewed on Feb. 23, 2009). With: Natural disordered sequences in the amino terminal domain of nuclear receptors : lessons from the androgen and glucocorticoid receptors / Iain J. McEwan ... et al. Nuclear Receptor Signalling. 2007: 5. Includes bibliographical references.

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Books on the topic "Steroid hormones"

1

C, Spelsberg T., and Kumar Rajiv 1949-, eds. Steroid and sterol hormone action. Boston: Nijhoff, 1987.

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B, Hochberg Richard, Naftolin Frederick, and Serono Foundation Symposium (1990 : Budapest, Hungary), eds. The New biology of steroid hormones. New York: Raven Press, 1991.

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A, Lieberman Benjamin, ed. Steroid receptor methods: Protocols and assays. Totowa: Humana Press, 2001.

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Advanced Course on Steroid Enzymes and Cancer (9th 2008 Erice, Italy). Steroid enzymes and cancer. Malden, MA: Wiley-Blackwell, 2009.

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I, Mason J., ed. Genetics of steroid biosynthesis and function. London: Taylor & Francis, 2002.

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J, Alexander Nancy, and D'Arcangues C, eds. Steroid hormones and uterine bleeding. Washington, DC: AAAS Press, 1992.

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B, Green, and Leake R. E, eds. Steroid hormones: A practical approach. Oxford: IRL, 1987.

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B, Green, and Leake R. E, eds. Steroid hormones: A practical approach. Oxford: IRL Press, 1987.

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1945-, Moudgil V. K., ed. Recent advances in steroid hormone action. Berlin: De Gruyter, 1987.

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1945-, Moudgil V. K., ed. Molecular mechanism of steroid hormone action: Recent advances. Berlin: Walter de Gruyter, 1985.

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Book chapters on the topic "Steroid hormones"

1

Milgrom, Edwin, and Alfred Jost. "Steroid Hormones." In Hormones, 385–442. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3060-8_9.

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Lindzey, Jonathan, and Kenneth S. Korach. "Steroid Hormones." In Endocrinology, 47–62. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-59259-641-6_4.

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Lynch, Gordon S., David G. Harrison, Hanjoong Jo, Charles Searles, Philippe Connes, Christopher E. Kline, C. Castagna, et al. "Steroid Hormones." In Encyclopedia of Exercise Medicine in Health and Disease, 817–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_258.

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Sandow, Jürgen. "Adrenal Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 3393–440. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05392-9_76.

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Sandow, Jürgen. "Testicular Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 3477–99. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05392-9_78.

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Sandow, Jürgen. "Adrenal Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 1–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27728-3_76-1.

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Sandow, Jürgen. "Testicular Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 1–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27728-3_78-2.

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Kleine, Bernhard, and Winfried G. Rossmanith. "Hormones from Mevalonate: Juvenile Hormone and Steroid Hormones." In Hormones and the Endocrine System, 191–236. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-15060-4_6.

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Shore, Laurence. "Steroid Hormones and Enzymes." In Emerging Topics in Ecotoxicology, 7–12. New York, NY: Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-92834-0_2.

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Dobriner, K. "Steroid Hormones and Cancer." In Ciba Foundation Symposium - Steroid Hormones and Tumour Growth (Book I of Colloquia on Endocrinology, Vol. 1), 187–97. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470718759.ch15.

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Conference papers on the topic "Steroid hormones"

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Samoilova, Elena S., Vyacheslav I. Fedorov, Olga P. Cherkasova, and Yuri P. Meshalkin. "Laser-induced fluorescent spectroscopy of steroid hormones." In Saratov Fall Meeting 2001, edited by Valery V. Tuchin. SPIE, 2002. http://dx.doi.org/10.1117/12.475592.

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Yaglova, Nataliya. "DEVELOPMENT AND FUNCTION OF THE ADRENAL CORTEX| IN EXPOSED TO ENDOCRINE DISRUPTOR DDT ORGANISMS." In NEW TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2021. http://dx.doi.org/10.47501/978-5-6044060-1-4.09.

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The present investigation found that developmental exposure to endocrine disruptor DDT affects mechanisms, regulating morphogenesis of adrenal cortex, and production of steroid hormones in pubertal period and adulthood.

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Kai Cai, Chris Elliott, and Lisa Connolly. "Analysis of steroid hormones in a constructed wetland systems." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5781045.

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Fedorov, Viacheslav I., Olga P. Cherkasova, and Elena S. Samoilova. "Native fluorescence of steroid hormones excited by UV laser radiation." In SPIE Proceedings, edited by Valery V. Tuchin. SPIE, 2004. http://dx.doi.org/10.1117/12.578355.

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Ataei, Abdol Hossain, and Figen Kırkpınar. "Application of In-Ovo Injection of Some Substances for Manipulation of Sex and Improving Performance in Chicken." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.006.

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In intensive production, freshly hatched cockerels are culled in the layer hatchery (7 billion males each year), On the other hand, for meat production rearing female birds has not economic benefits because of male broiler chicks have a faster growth rate and better feed efficiency than females. In this regards several methods are being developed for sex determination in the chick embryo during the incubation period. But these methods need to be rapid, cost-efficient, and suitable practical for commercial use. Additionally, sex determination should be done before pain perception has evolved in chick embryos. Biotechnology by in ovo technique to sex determination of between male and female chicks or sex reversal could improve production and eliminate ethical dilemmas for poultry industries. In birds, the differentiation of embryonic gonads is not determined by genetic gender with the certainty that occurs in mammals and can be affected by early treatment with a steroid hormone. During the development of the chick embryo, the genotype of the zygote determines the nature of the gonads, which then caused male or female phenotype. The differentiation of gonads during the period called the "critical period of sexual differentiation" is accompanied by the beginning of secretion of sexual hormones. Namely, any change in the concentration of steroid hormones during the critical period affects the structure of the gonads. Many synthetic anti-aromatases such as federazole and non-synthetic in plants, mushrooms, and fruits containing natural flavonoids have been used in the experiments in ovo injection of anti-aromatase had no negative effect on the growth performance of sexual reversal female chickens. In conclusion, administration of an aromatase inhibitor causes testicular growth in the genetic female gender, and estrogen administration leads to the production of the left ovotestis in the genetic male gender. Therefore, in the early stages of embryonic development, sexual differentiation can be affected by changing the ratio of sexual hormones. In this review, effects of some substances applied by in ovo injection technique on sex reversal and performance in chicks.

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Christensen, Carol, Sabine Rohrmann, Nader Rifai, and Elizabeth Platz. "Abstract A83: Organophosphate pesticides and sex steroid hormones in NHANES III." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-a83.

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Kotrikadze, N., I. Nakashidze, L. Ramishvili, M. Alibegashvili, N. Petrovic, T. Peshkova, B. Sepiashvili, et al. "137 The alteration of lipids and steroid hormones in breast tumors." In IGCS Annual 2019 Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-igcs.137.

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Nakashidze, I., N. Kotrikadze, E. Gogitidze, L. Ramishvili, N. Petrovic, M. Alibegashvili, N. Kedelidze, et al. "138 Selected tumor markers and sex-steroid hormones in breast tumors." In IGCS Annual 2019 Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-igcs.138.

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Jovanović-Šanta, Suzana S., Aleksandar M. Oklješa, Antos B. Sachanka, Yaraslau U. Dzichenka, and Sergei A. Usanov. "17-SUBSTITUTED STEROIDAL TETRAZOLES – NOVEL LIGANDS FOR HUMAN STEROID-CONVERTING CYP ENZYMES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.336js.

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In animal and human organisms, there are many enzymes, members of the family of heme- containing proteins, cytochromes P450 (CYPs), included in the biosynthesis and metabolism of many biomolecules, as cholesterol, bile acids, sex, and corticosteroid hormones, as well as in metabolism of drugs and xenobiotics. It is also well-known that different imidazole and triazole derivatives are efficient inhibitors of CYPs activity. In this study, we present in vitro screening of binding of novel androstane derivatives with tetrazole- containing substituents in position 17 to human recombinant steroid-converting CYP enzymes: CYP7A1, CYP7B1, CYP17A1, CYP19, and CYP21. Initial screening was performed using a high throughput screening approach, while the affinity of the ligands was analyzed using spectrophotometric titration. For some among tested compounds type I spectral response (substrate-like binding) for CYP7A1 selectively, while for one compound type II spectral response (inhibitor-like binding) for CYP21 were detected, with micromolar values of Kds. Interestingly, one compound with mixed spectral response was found to bind for CYP7B1, which means that there are two optimal positions of the ligand inside the protein active site. Such results could be useful in CYP-inhibiting drug development, during a fast, high-throughput screening of pharmacological potential of novel compounds, as well as in side- effects recognizing.

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Ferreira, Christian G., Isabela P. Paim, Mirelly A. Tomaz, Isadora Â. Borges, Andressa M. Maciel, and Ana B. M. Sallum. "Major depressive disorder caused by abrupt cessation of anabolic steroid use: Case report." In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-263.

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This case report shows how the misuse of anabolic steroids can lead to psychological, physiological and somatic disorders and disturbances that significantly affect a person's life. The patient in question presents depressive symptoms, in addition to gynecomastia, after indiscriminate use of anabolic hormones followed by its sudden interruption. After laboratory, clinical and imaging evaluation, a diagnosis of major depressive disorder with anxiety components was made. A drug therapeutic intervention was proposed for symptomatic control, as well as a surgical evaluation for varicocele correction. This case reveals the importance of caution when using anabolic steroids for aesthetic purposes, which often lead to severe bodily and psychological changes.

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Reports on the topic "Steroid hormones"

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Wallace, Margaret R. Steroid Hormones in NF1 Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, August 2005. http://dx.doi.org/10.21236/ada443895.

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Wallace, Margaret R., David Muir, and Martha Campbell-Thompson. Steroid Hormones in NF1 Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, August 2004. http://dx.doi.org/10.21236/ada428454.

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Wallace, Margaret R., David Muir, and Martha Campbell-Thompson. Steroid Hormones in NF1 Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, August 2002. http://dx.doi.org/10.21236/ada411283.

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Li, Jianming. Perception of Plant Steroid Hormones at the Cell Surface. Office of Scientific and Technical Information (OSTI), March 2013. http://dx.doi.org/10.2172/1069267.

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Tsai, Sophia Y. The Interaction of Steroid Hormones and Oncogene in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 1998. http://dx.doi.org/10.21236/ada361178.

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Tsai, Sophia Y. The Interaction of Steroid Hormones and Oncogene in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 1997. http://dx.doi.org/10.21236/ada335989.

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Tsai, Sophia Y. The Interaction of Steroid Hormones and Oncogene in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 1995. http://dx.doi.org/10.21236/ada302472.

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Savaldi-Goldstein, Sigal, and Siobhan M. Brady. Mechanisms underlying root system architecture adaptation to low phosphate environment. United States Department of Agriculture, January 2015. http://dx.doi.org/10.32747/2015.7600024.bard.

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In order to advance our understanding towards potential biotechnology improvement of plant performance, we studied root responses to limited P in two different plants, Arabidopsis and tomato. Arabidopsis is among the most studied model plants that allows rapid application of molecular and developmental experiments while tomato is an important crop, with application in agriculture. Using Arabidopsis we found that steroid hormones modulate the extent of root elongation in response to limited P, by controlling the accumulation of iron in the root. We also found that the availability of P and iron control the activity of the steroid hormone in the root. Finally, we revealed the genes involved in this nutrient-hormone interaction. Hence, the ferroxidase LPR1 that promotes iron accumulation in response to low P is repressed by the transcription factor BES1/BZR1. Low P inhibits the steroid hormone pathway by enhancing the accumulation of BKI1. High levels of BKI1 inhibit the activity of the steroid hormone receptor at the cell surface and iron accumulation increases inside the root, resulting in a slow growth. Together, the extent of root elongation depends on interactions between an internal cue (steroid hormone) and cues derived from the availability of P and iron in the environment. Using tomato, we found that the response of two cultivated tomato varieties (M82 and New Yorker) to limited P is distinct from that of the wild species, Solanumpennellii. This is implicated at both the levels of root development and whole plant physiology. Specifically, while the root system architecture of cultivated tomato is modulated by limited P availability, that of the wild type species remained unaffected. The wild species appears to be always behaving as if it is always in phosphate deprived conditions, despite sufficient levels of phosphate. Hyper-accumulation of metals appears to mediate this response. Together, this knowledge will be used to isolate new genes controlling plant adaptation to limited P environment.

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Bahrevar, Roghaye, Mohamad Reza Ghomi, and Mehdi Sohrabnezhad. Correlation between Serum Steroid Hormones and Body Size in Cultured Beluga Sturgeon (Huso huso). "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, December 2019. http://dx.doi.org/10.7546/crabs.2019.11.06.

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Bechshoft, Thea. Measuring and Validating Levels of Steroid Hormones in the Skin of Bottlenose Dolphins (Tursiops Truncatus). Fort Belvoir, VA: Defense Technical Information Center, September 2015. http://dx.doi.org/10.21236/ad1013956.

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