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Relevant bibliographies by topics / Steroid drug

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Academic literature on the topic 'Steroid drug'

Author: Grafiati

Published: 18 May 2024

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Journal articles on the topic "Steroid drug"

1

Isnenia, Isnenia. "Penggunaan Non-Steroid Antiinflamatory Drug dan Potensi Interaksi Obatnya Pada Pasien Muskuloskeletal." Pharmaceutical Journal of Indonesia 6, no. 1 (December 1, 2020): 47–55. http://dx.doi.org/10.21776/ub.pji.2020.006.01.8.

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The main therapy on musculoskeletal patients is the use of non-steroidal anti-inflammatory drugs (NSAIDs) either as monotherapy or in combination with drugs of the same class or pain relievers from other groups. The use of more than one drugs have potentially caused drug-drug interactions that can affect to patient. This study was aimed to describe the patient's sociodemographic (sex, ages) and clinical (numbers of drugs, type of drugs and diagnose) characteristics, as well as to find the correlation between potential drug interactions with these variables. This research was a quantitative study with a cross sectional design. Data were taken from 100 medical records of patients who had diagnosed with top five musculoskeletal diseases. Data were analyzed descriptively for sex, ages, number of drugs, type of drugs, and potential drug interactions. Bivariate correlation with chi-square were conducted to find statistically significancy potential drug interactions with each variable consist of sex, ages, type of drugs and it’s diagnose. The result shows that the musculoskeletal patients were 44% male, 56% female. Most musculoskeletal patients were aged 18-65 years (78%). Patients who received drugs <5 were 68% and ≥ 5 were 32%. 54% of patients were taking the diclofenac and only 5% of patients were taking the two NSAIDs combination, diclofenac and ibuprofen. There was no significant correlation (p > 0,05) between potential drug interactions with age, sex, type of NSAID, and type of musculosceletal diseases.

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Denham, Bryan E. "Determinants of Anabolic-Androgenic Steroid Risk Perceptions in Youth Populations: A Multivariate Analysis." Journal of Health and Social Behavior 50, no. 3 (September 2009): 277–92. http://dx.doi.org/10.1177/002214650905000303.

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Grounded conceptually in social cognitive theory, this research examines how personal, behavioral, and environmental factors are associated with risk perceptions of anabolic-androgenic steroids. Ordinal logistic regression and logit log-linear models applied to data gathered from high-school seniors (N = 2,160) in the 2005 Monitoring the Future study showed significant explanatory effects for sex, race, exposure to drug spots, steroid availability, peer use of steroids, sensation-seeking, depression, and self-esteem. Females, African Americans, and those who had seen drug spots the most frequently estimated higher levels of risk associated with steroid use, while those who indicated ease in obtaining steroids and those with close friends who had used the drugs estimated lower risk. Also estimating lower levels of risk were sensation seekers, those who appeared depressed, and those with low levels of self-esteem. Analyses reveal how steroid risk determinants may differ from those related to methylenedioxymethamphetamine (i.e., MDMA, ecstasy) and marijuana use.

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Lykhonosov, Mykola P., and Alina Yu Babenko. "Prevalence of anabolic androgenic steroid use, its effect on the male pituitary-gonadal axis, and the possibility of reproductive rehabilitation." Problems of Endocrinology 65, no. 2 (June 30, 2019): 124–33. http://dx.doi.org/10.14341/probl9997.

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The purpose of this review is to assess the prevalence of AA steroid use, to identify the steroids that are used, and to present the negative effects of AA steroids on the human body while describing the mechanisms of their actions on the male reproductive system. The review highlights the diagnostic features of steroid-induced hypogonadism, and assesses the effectiveness of various drugs in the reproductive rehabilitation of patients who cease taking AA steroids. Emphasis is placed on the feasibility and effectiveness of various drug treatments in the context of post cycle therapy (PCT), which seeks to stabilize and restore normal hormonal function. All this data is necessary for the development of modern treatment algorithms for steroid-induced hypogonadism in men.

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Thanage, Ravi, Sanjay Chandnani, Vinay Zanwar, Shubham Jain, Samit Jain, Qais Contractor, and Pravin Rathi. "Unusual Case of Simultaneous Acute Hepatitis and Acute Pancreatitis in a Bodybuilder." Journal of Gastroenterology, Pancreatology & Liver Disorders 7, no. 1 (February 2, 2019): 1–3. http://dx.doi.org/10.15226/2374-815x/7/1/001137.

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The use of anabolic steroids is widespread, particularly among bodybuilders. Most athletes have only a crude pharmacological knowledge regarding these drugs and warnings of steroid misuse are neglected. The illicit use of Androgenic Anabolic Steroids (AAS) to obtain an athletic, healthy looking body can lead to serious and often irreversible organ damage [1]. Anabolic steroids with 17 alpha carbon substitutions have been associated with a cholestatic injury with little hepatocellular injury. In the case of hepatoxicity and severe cholestasis the prompt withdrawal of the steroid and the administration of ursodeoxycholic acid are recommended [2]. Steroid also is known to cause acute pancreatitis which would result in acute onset abdominal pain and vomiting. Possible mechanisms for drug-induced pancreatitis include immune-mediated inflammatory response, direct cellular toxicity, arteriolar thrombosis, and metabolic effects.

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Arul Balasubramanian, Rinson Reji, Rosmy Jose, Sarika Sasidharan, and Kothai Ramalingam. "Drug utilization review of corticosteroids in a tertiary care hospital of Salem District, Tamilnadu, India." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (July 20, 2019): 2246–49. http://dx.doi.org/10.26452/ijrps.v10i3.1459.

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Corticosteroids are widely used compounds for allergic reactions, autoimmune diseases, inflammatory conditions, hormone replacement therapy etc. Hence, with widespread use and actions, these have several interactions with drugs and diseases. The purpose of this study was to obtain information about Corticosteroids prescribing and utilization pattern, to understand the prescribing behaviour of physicians and to identify drug interactions. A retrospective observational study was conducted in the department of dermatology and general medicine in a tertiary care hospital for 6 months. All the patients receiving any category of steroid therapy were included, and the prescribing and tapering pattern of steroids were reviewed. Drug utilization pattern (DUR) was observed and analysed among 150 patients during the study period. The results revealed that steroids were prescribed for various respiratory illnesses (66%) and skin-related conditions (34%). The steroid utilization was found to be more in elderly patients, particularly in males. Intravenous administration was common in 33% of cases. Budesonide was the most commonly prescribed steroid (36%), followed by Hydrocortisone (24%) and Dexamethasone (14%). The most frequent drug-drug interaction was between Hydrocortisone and Theophylline as well as Hydrocortisone and Hypoglycaemic agents. Most drugs were prescribed rationally, although some factors like prescribing drugs in the brand name, without mentioning route of administration, frequency and dose were deviating away from rationality. Not much variation was found in the pattern of prescription amongst healthcare professionals. Although most of the drugs were prescribed rationally, the involvement of a clinical pharmacist in patient care can help in more rational prescribing along with prevention and early detection of ADRs which can directly promote drug safety and better patient outcomes.

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Cassinotti, A., S. Saibeni, A. De Silvestri, N. Mezzina, D. Di Paolo, E. Alimenti, M. L. Annunziata, et al. "P771 Biologics versus azathioprine in steroid-dependent ulcerative colitis: results from the A.U.R.O.R.A. database." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i900. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0901.

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Abstract Background The A.U.R.O.R.A. database is an Italian multicenter retrospective cohort of patients with ulcerative colitis (UC) treated with the first biological drugs (infliximab biosimilar- IFX-B, adalimumab-ADA, golimumab-GOL, vedolizumab-VDZ) approved in Italy after patent expire of IFX-originator. In a previous published study,1 we showed similar efficacy among all drugs according to the rigorous outcome of 1-year “continuous clinical remission” (CCR). In this study, we focused only on steroid-dependent UC, by comparing all drugs to each other and to patients treated with steroids followed by azatioprine (AZA) monotherapy. Methods All consecutive patients with steroid-dependent UC, treated with IFX-B, ADA, GOL or VDZ after their approval in 2014-2019, were followed-up for 1 year or until drug discontinuation for relapse or adverse events. All drugs were compared to each other and to steroid-dependent patients treated with steroids + AZA in 2006-2014. A propensity score analysis was performed to balance differences at baseline. The primary endpoint was the 1-year CCR, defined as steroid-free clinical remission with Mayo partial score ≤2 (with no bleeding), without any clinical relapse or treatment optimization after the first remission was achieved, and without drug withdrawal due to adverse events. Treatment optimization was defined as the addition of systemic/topical steroids, oral/topical mesalazine or any dose escalation of biologics Results 370 patients (IFX-B=62, ADA=68, GOL=56, VDZ=100, AZA 84) with steroid-dependent UC were included. No significant differences were found among each biological drug according to the 1-year CCR primary end-point (34%, 29%, 30%, 39%, respectively). In patients naive to immunesuppressors and biologics (n= 17, 25, 24 10, 79, respectively), AZA showed significantly higher rate of CCR (68%) than each biological drug (35%, 44%, 33%, 60%; p=0.000 for each comparison) or all biologics as a whole (41%; p=0.012). Adverse events occurred significantly less frequently with ADA (8%) than IFX (29%), GOL (20%) and AZA (26%) in the overall population, but were similar across all drugs in the naive population. Discontinuation for adverse events occurred more frequently (p<0.05) with both IFX-B (16%) and AZA (14%) than ADA (3%), GOL (4%), and VDZ (1%) in the overall population, but not in the naive population (18%, 15%, 4%, 4%, 0%, respectively). Conclusion In steroid-dependent UC, anti-TNF-alpha agents and VDZ were equally effective at 1 year according to the concept of CCR. AZA still appears an effective first-line strategy in the biological era. 1Cassinotti A. et al. Eur J Gastroenterol Hepatol. 2022;34:1238-46. Guided Poster Session

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Bharat Sharma. "Medically Significant Hypersensitivity Reaction to Dapsone: A Case Report." International Healthcare Research Journal 2, no. 1 (April 10, 2018): 10–11. http://dx.doi.org/10.26440/ihrj/02_01/157.

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The drug Dapsone is a component of the World Health Organization multidrug therapy being used against leprosy. Although it has shown a good efficacy during the years, a few subjects develop adverse drug reactions associated with dapsone .We report a case of a patient who was prescribed dapsone as part of multiple drug therapy for leprosy following which he developed Dapsone induced Hypersensitivity Syndrome (DHS). He was prescribed steroids with a tapering dose. His condition worsened after weaning of the oral steroids. He also developed steroid-induced diabetes which was stabilized using anti-diabetic drugs.

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Zhang, Yang, Peiyao Xiao, Delong Pan, and Xiuling Zhou. "New Insights into the Modification of the Non-Core Metabolic Pathway of Steroids in Mycolicibacterium and the Application of Fermentation Biotechnology in C-19 Steroid Production." International Journal of Molecular Sciences 24, no. 6 (March 9, 2023): 5236. http://dx.doi.org/10.3390/ijms24065236.

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Androsta-4-ene-3,17-dione (AD), androsta-1,4-diene-3,17-dione (ADD), and 9α-hydroxy-4-androstene-3,17-dione (9-OHAD), which belong to C-19 steroids, are critical steroid-based drug intermediates. The biotransformation of phytosterols into C-19 steroids by Mycolicibacterium cell factories is the core step in the synthesis of steroid-based drugs. The production performance of engineered mycolicibacterial strains has been effectively enhanced by sterol core metabolic modification. In recent years, research on the non-core metabolic pathway of steroids (NCMS) in mycolicibacterial strains has made significant progress. This review discusses the molecular mechanisms and metabolic modifications of NCMS for accelerating sterol uptake, regulating coenzyme I balance, promoting propionyl-CoA metabolism, reducing reactive oxygen species, and regulating energy metabolism. In addition, the recent applications of biotechnology in steroid intermediate production are summarized and compared, and the future development trend of NCMS research is discussed. This review provides powerful theoretical support for metabolic regulation in the biotransformation of phytosterols.

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Bohl, Martin, and Manfred Wunderwald. "Molecular Mechanics Investigation on Conformational Flexibility of 14β Steroids in Drug-Receptor Interactions." Zeitschrift für Naturforschung C 41, no. 3 (March 1, 1986): 297–300. http://dx.doi.org/10.1515/znc-1986-0309.

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The interaction between two 14 β steroids being still unsynthesized and a model receptor binding site is theoretically studied by a molecular mechanics scheme. Both com pounds containing seven-membered rings in the 17 β position are found to form stable hydrogen bonds to the receptor and can be attributed to be potential inhibitors of the Na +,K + -ATPase activity. Substantial steroid conformational changes necessary for an efficient receptor binding are calculated to reduce the interaction energy by only 10 kJ mol -1. Therefore, alterations in steroid structure should be generally taken into consideration in the investigation of steroid-receptor interactions.

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David Smith and Venu Sen. "The Toxicity of Corticosteroids." International Healthcare Research Journal 5, no. 10 (January 30, 2022): RV5—RV9. http://dx.doi.org/10.26440/ihrj/0510.01498.

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Minimization of steroid therapy has always been one of the main objectives of immunosuppressive protocols after kidney transplantation, due to numerous side effects. The use of a further reduced daily dose of steroids is considered by many to be a fair compromise between toxicity and efficacy. Unfortunately, the great inter-individual variability of the pharmacokinetics of steroids does not prevent the appearance of major side effects in a variable percentage of patients, even with the low dose used. A drug interaction between steroids and drugs used after transplantation can also contribute to increasing daily exposure to the drug. Steroid discontinuation is still the only procedure capable of achieving the desired goal. This procedure is associated with a greater risk of acute rejection, without however reducing the survival of the transplant. It should be offered to patients at low immunological risk. Early discontinuation, during the first week of transplantation, is also the modality suggested by some guidelines, although a later suspension also offers excellent results. Induction therapy is always recommended in the case of early discontinuation.

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Dissertations / Theses on the topic "Steroid drug"

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Cuervo, Alfredo Carabot. "Chemical studies on steroidal sapogenin producing plants of Venezuela." Thesis, University of Portsmouth, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.255340.

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Robinson, David Thomas. "The metabolism of trilostane and epostane." Thesis, University of Surrey, 1989. http://epubs.surrey.ac.uk/847952/.

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Trilostane and epostane are synthetic steroids which inhibit the 3beta-hydroxysteroid dehydrogenase enzyme. This enzyme is part of a system which catalyses an essential step in the synthesis of biologically active steroids. In animals and man trilostane preferentially inhibits adrenal steroid synthesis whilst epostane inhibits placental/ovarian steroid synthesis. The synthesis of radiolabelled trilostane and epostane are described. Stability investigations showed these radiolabelled compounds to be susceptible to degradation, although trilostane less so than epostane. Careful handling procedures were essential for metabolism studies. Animal studies showed no difference in the overall excretion and distribution of radioactivity for [[14]Cl-trilostane and [[14]C]-epostane. However the site specific localisation of active components within adrenals and ovaries reflected the in vivo organ selectivity observed for these compounds. In man a major plasma metabolite of trilostane was shown to be 17-ketotrilostane which is intrinsically twice as active as parent compound with regard to 3beta-hydroxysteroid dehydrogenase inhibition. A specific, sensitive and accurate HPLC assay was developed which enabled the measurement of trilostane and 17-ketotrilostane in plasma. Plasma concentrations of 17-ketotrilostane in male volunteers were approximately three-fold higher than trilostane, and consequently this metabolite may be an important contributor to the clinical efficacy of this drug. Micronisation of both trilostane and epostane was shown to be appropriate in order to maximise the oral systemic availability of these compounds. However even with micronised formulations considerable inter-and intra-subject variability was noted. For trilostane, variability in absorption, coupled with individual differences in the metabolism to the more active 17-ketotrilostane, may in part account for the variable efficacy encountered in clinical trials.

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Parmar, Rina. "The interaction of a model steroid with phospholipid structures." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265759.

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Barr, J. "Sex differences in drug and steroid metabolism in rat liver : Biochemical basis." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379310.

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Fiandaca, Maggie. "Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug." Thesis, University of the Sciences in Philadelphia, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=22620871.

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The present work focuses on modifying a non-steroid anti-inflammatory drug (NSAID) into an ionic liquid and evaluating the resulting thermal behavior and structural changes of the drug. Naproxen was chosen as the NSAID molecule due to thermal stability and limited examples of its use as an ionic liquid in current literature. Lidocaine was chosen as the counterion based on a screening study of potential ionic liquid formers. The screening included both potential protic and aprotic formation and counterions were included with consideration to pKa, hydrogen bonding ability, molecular size, diffuse charge distribution and functional groups. Analytical techniques used to evaluate the counterions included high performance liquid chromatography (HPLC), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Naproxen and lidocaine were then combined in varying molar ratios to determine the thermal behavior of the mixtures. The samples with equimolar, or higher, ratio of naproxen showed a phase which had a melting point of 82–85 °C. The DSC data was analyzed using a modified Tamman plot, resulting in the unexpected and previously unreported behavior of ionic liquid formation at a 2:1 molar ratio of naproxen to lidocaine, referred to as IL1 in this research. This stoichiometry was confirmed through Fourier Transformed Infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy methods. The samples that contained a higher molar ratio of lidocaine than naproxen, resulted in material more consistent with higher-order complex clusters. Further characterization of IL1 found that the material demonstrated behaviors of an ionic liquid, including weak intermolecular forces and at least partial ionization of the drug and counterion.

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Modak, Subhendu Bhusan. "Plant physiological investigation on production of steroid drug yielding solanum viarum dunal available in North Bengal." Thesis, University of North Bengal, 1992. http://hdl.handle.net/123456789/901.

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Skårberg, Kurt. "Anabolic-androgenic steroid users in treatment : social background, drug use patterns, and criminality." Doctoral thesis, Örebro universitet, Hälsoakademin, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-6249.

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Soto, Laveaga Gabriela. "Root of discord : steroid hormones, a wild yam, peasants and state formation in Mexico (1941-1986) /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3023452.

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Thesis (Ph. D.)--University of California, San Diego, 2001.
Vita. Accompanying videorecording (14 min. : sd., col. ; 1/2 in.) has title: Barbasco, la raíz de la discordia. Includes bibliographical references (leaves 248-266).

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Spence, John Cochrane. "Mood changes associated with anabolic-androgenic steroid use in male bodybuilders." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60580.

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The present study described the daily moods of male bodybuilders who self-administered large doses of anabolic-androgenic steroids (AS) through a full cycle of steroid use. Male bodybuilders (N = 13) who had been self-administering AS for 2.5 to 12 years served as subjects and participated in a 14 to 16 week experience sampling procedure wherein brief mood questionnaires were filled out twice daily.
Findings revealed that 11 of the 13 subjects experienced self-reported mood changes in association with AS use. In particular, 2 subjects (subjects 4 & 11) experienced quite dramatic changes in mood. It is concluded that there is much variability with regards to the psychological effects that humans may display in association with AS use.
Data are discussed in terms of the effects that AS use may have on mental health.

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Pennington, Cody W. "The Academic Steroid: Nonmedical Use of Prescription Stimulants at a North Texas University." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc699893/.

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The goal of this study was to determine the extent, motivations, and justifications of nonmedical prescription stimulant use among the population at a large public university in the North Texas region. Participants consisted of 526 undergraduate students enrolled at the studied university during the spring and summer 2014 semesters. The findings of the study suggest that the nonmedical use by students was higher than the findings in much of the current literature, but was within the parameters established in the literature. The primary motivation for nonmedical use was academic in nature and was justified by moderation of nonmedical use to strategic academic times.

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Books on the topic "Steroid drug"

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Steroid drug dangers. Springfield, NJ: Enslow Publishers, 1999.

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Steroid abuse. Detroit, MI: Lucent Books, 2010.

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National Institute on Drug Abuse, ed. Anabolic steroid abuse. 2nd ed. [Rockville, Md.?]: National Institute on Drug Abuse, 2000.

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National Institute on Drug Abuse., ed. Anabolic steroid abuse. 2nd ed. [Rockville, Md.?]: National Institute on Drug Abuse, 2000.

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Ian, Adcock, and Chung K. Fan 1951-, eds. Overcoming steroid insensitivity in respiratory disease. Chichester, West Sussex: J. Wiley, 2008.

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Lutfun, Nahar. Steroid dimers: Chemistry and applications in drug design and delivery. Chichester, West Sussex: John Wiley & Sons, 2012.

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Harry, Shapiro, and Institute for the Study of Drug Dependence., eds. The steroids papers: A collection of articles from Druglink and elsewhere on one of Britain's hidden drug issues. London: Institute for the Study of Drug Dependence, 1993.

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J, Alexander Nancy, and D'Arcangues C, eds. Steroid hormones and uterine bleeding. Washington, DC: AAAS Press, 1992.

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Antitumor steroids. San Diego: Academic Press, 1992.

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Lutfun, Nahar. Steroid dimers: Chemistry and applications in drug design and delivery. Chichester, West Sussex: John Wiley & Sons, 2012.

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Book chapters on the topic "Steroid drug"

1

Sandor, Z., and S. Szabo. "Steroid Ulcers." In Drug-Induced Injury to the Digestive System, 33–53. Milano: Springer Milan, 1993. http://dx.doi.org/10.1007/978-88-470-2220-1_4.

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Sandow, Jürgen. "Adrenal Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 3393–440. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05392-9_76.

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Sandow, Jürgen. "Testicular Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 3477–99. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05392-9_78.

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McVenes, Rick, and Ken Stokes. "Steroid-Releasing Lead." In Drug-Device Combinations For Chronic Diseases, 117–41. Hoboken, New Jersey: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119002956.ch05.

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Sandow, Jürgen. "Adrenal Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 1–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27728-3_76-1.

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Sandow, Jürgen. "Testicular Steroid Hormones." In Drug Discovery and Evaluation: Pharmacological Assays, 1–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27728-3_78-2.

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Behl, Christian. "Estrogen is a steroid." In Estrogen — Mystery Drug for the Brain?, 16–24. Vienna: Springer Vienna, 2001. http://dx.doi.org/10.1007/978-3-7091-6189-0_2.

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Coomber-Moore, Jake, Nigel South, Ross Coomber, and Leah Moyle. "‘Steroid holidays' as drug tourism and deviant leisure." In Understanding Drug Dealing and Illicit Drug Markets, 188–207. London: Routledge, 2023. http://dx.doi.org/10.4324/9781351010245-11.

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Wyse-Jackson, Alice C., Gillian Groeger, and Thomas G. Cotter. "CHAPTER 8. Beyond Anti-inflammation: Steroid-induced Neuroprotection in the Retina." In Drug Discovery, 113–43. Cambridge: Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788013666-00113.

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Back, D. J., and M. L’E Orme. "Pharmacokinetic Drug Interactions with Oral Contraceptives." In Steroid Contraceptives and Women’s Response, 103–23. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2445-8_10.

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Conference papers on the topic "Steroid drug"

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Doan, Jessica, Peter Phommahaxay, Sarah Olson, and Matthew A. Petersen. "Formulation and Characterization of Thermoplastic Polyurethane-Based Steroid Eluting Devices." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3254.

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We describe the formulation and manufacture of thermoplastic polyurethane (TPU)-based steroid-eluting components and the development of a versatile, material-agnostic analytical method for their rapid characterization. The impact of materials, formulation, and processing on controlled release behavior was characterized and compared to current industry standard components under physiologically relevant conditions. The combination of factors modulated drug release, offering new avenues for controlling the release of steroids from implantable medical devices.

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Jovanović-Šanta, Suzana S., Aleksandar M. Oklješa, Antos B. Sachanka, Yaraslau U. Dzichenka, and Sergei A. Usanov. "17-SUBSTITUTED STEROIDAL TETRAZOLES – NOVEL LIGANDS FOR HUMAN STEROID-CONVERTING CYP ENZYMES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.336js.

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In animal and human organisms, there are many enzymes, members of the family of heme- containing proteins, cytochromes P450 (CYPs), included in the biosynthesis and metabolism of many biomolecules, as cholesterol, bile acids, sex, and corticosteroid hormones, as well as in metabolism of drugs and xenobiotics. It is also well-known that different imidazole and triazole derivatives are efficient inhibitors of CYPs activity. In this study, we present in vitro screening of binding of novel androstane derivatives with tetrazole- containing substituents in position 17 to human recombinant steroid-converting CYP enzymes: CYP7A1, CYP7B1, CYP17A1, CYP19, and CYP21. Initial screening was performed using a high throughput screening approach, while the affinity of the ligands was analyzed using spectrophotometric titration. For some among tested compounds type I spectral response (substrate-like binding) for CYP7A1 selectively, while for one compound type II spectral response (inhibitor-like binding) for CYP21 were detected, with micromolar values of Kds. Interestingly, one compound with mixed spectral response was found to bind for CYP7B1, which means that there are two optimal positions of the ligand inside the protein active site. Such results could be useful in CYP-inhibiting drug development, during a fast, high-throughput screening of pharmacological potential of novel compounds, as well as in side- effects recognizing.

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Herrlich, S., S. Spieth, H. Gerstmann, A. Virnich, F. Zipfel, A. Kitschmann, T. Goettsche, P. Osypka, and R. Zengerle. "Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6346023.

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4

Bíró, Tivadar, and Zoltán Aigner. "In vitro and ex vivo investigation of steroid containing ocular drug delivery systems." In II. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2020. http://dx.doi.org/10.14232/syrptbrs.2020.op1.

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Ferreira, Christian G., Isabela P. Paim, Mirelly A. Tomaz, Isadora Â. Borges, Andressa M. Maciel, and Ana B. M. Sallum. "Major depressive disorder caused by abrupt cessation of anabolic steroid use: Case report." In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-263.

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This case report shows how the misuse of anabolic steroids can lead to psychological, physiological and somatic disorders and disturbances that significantly affect a person's life. The patient in question presents depressive symptoms, in addition to gynecomastia, after indiscriminate use of anabolic hormones followed by its sudden interruption. After laboratory, clinical and imaging evaluation, a diagnosis of major depressive disorder with anxiety components was made. A drug therapeutic intervention was proposed for symptomatic control, as well as a surgical evaluation for varicocele correction. This case reveals the importance of caution when using anabolic steroids for aesthetic purposes, which often lead to severe bodily and psychological changes.

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Sadava, David, and Susan E. Kane. "Abstract 183: Brassinolide, a plant steroid hormone, reverses drug resistance in human small-cell lung carcinoma cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-183.

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Weitman, Steven D., Michael Bittner, Pamela Hershberger, Robert E. Babine, Steven Nye, and James Yarger. "Abstract 1721: A steroid-based drug that binds estrogen receptor beta can inhibit cancer cell proliferation by blocking chromosome replication." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1721.

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Barakat, Farah M., Claire Barnes, Jonathan Baker, Akshay Batra, Nadeem A. Afzal, R. Mark Beattie, and Tracy A. Coelho. "P60 Ustekinumab is an effective drug for steroid-free remission in children with refractory IBD and anti TNF-alpha induced psoriasis." In Abstracts of the BSPGHAN Virtual Annual Meeting, 27–29 April 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/flgastro-2021-bspghan.69.

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Shields, Stephanie, Allan Dunlop, John Paul Seenan, and Jonathan Macdonald. "P111 Proactive therapeutic drug monitoring is not associated with lower rates of steroid exposure or excess in adalimumab treated IBD patients." In BSG LIVE’23, 19–22 June, ACC Liverpool. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2023. http://dx.doi.org/10.1136/gutjnl-2023-bsg.183.

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Abid Hamza ALALWANY, Ekhlas, Salim Salih Ali AL-KHAKANI, Isam M J ZABIBA, Siraj M. AL-KHAFAJI, Hawraa M. MURAD, and Marwah Najeh HAMMOOD. "EFFECT OF SUSTANON ON SKELETAL MUSCLES (ARM, THIGH) AND SOME OF BLOOD PARAMETERS IN FEMALE RATS (RATTUS RATTUS) IN BABYLON-IRAQ." In VI.International Scientific Congress of Pure,Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/rimarcongress6-4.

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There are random uses of androgenic anabolic steroids such as sustanon , especially among young people and adolescent.These drugs have many long-term negative side effects; therefore they have become one of major problem of health. This study was conducted in order to examine the effect of intramuscular injection of androgenic anabolic steroide (sustanon) on some hormonal, immunological and histological parameters in female albino rats. The study carried out in the animal house (College of Veterinary Medicine/ University of Al-Qassim green). Twenty Four female rats were divided into four groups (6 replication for each), the first, second and third treatment sub groups injected by sustanon at concentrations (0.05, 0.1, 0.2) mg/kg/day respectively for six weeks, while the fourth subgroup was considered a control set which injected by physiological normal saline (0.9%Nacl). The blood parameters estimation (RBCs, WBCs, PCV, PLT,Hb) Histologic study included studying histopathological changes in skeletal muscles tissue (thigh, arm). The results showed a significant increase (p ≤ 0.05) of the levels (Hb,RBCs, WBCs, PCV, PLT), compared with thecontrol group. Histology study changes showed that hypetrophy of fiber muscle in thigh and arm tissue with hyperplasia of muscle cells in arm at high doses present study conclude that increasing the concentrations of sustanon drug may cause clear pathological changes (physiologically, and histologically in most of the study parameters.

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Reports on the topic "Steroid drug"

1

Davis, Brian. Non-Steroidal Anti-Inflammatory Drug Use in Collegiate Athletes. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2474.

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Farhad Parhami, Farhad Parhami. Can hair loss be reversed with Oxy133, a sterol based drug candidate? Experiment, April 2018. http://dx.doi.org/10.18258/11042.

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Li, Xiao, GX Xu, FY Ling, ZH Yin, Y. Wei,, Y. Zhao, Xn Li, WC Qi, L. Zhao, and FR Liang. The dose-effect association between electroacupuncture sessions and its effect on chronic migraine: a protocol of a meta-regression of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0085.

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Review question / Objective: We will use a meta-regression approach to verify the dose-effect relationship between the number of electroacupuncture sessions and its effects on migraine. Condition being studied: Migraine is recurrent and chronic, requiring long-term control, but the side effects caused by long-term use limit the use of pharmacotherapy, like non-steroidal anti-inflammatory drugs (NSAIDS), ergoamines and opioids. With fewer side effects and lower cost, acupuncture is becoming a more attractive option for migraine. Relevant studies have confirmed the clinical effects of electroacupuncture on migraine and its effects on intracranial blood flow velocity, functional brain imaging and neuroinflammation. However, uncertainty exists regarding the dose-effect between electroacupuncture and migraine. In recent years, inspired by the dose-effect researches in pharmacology and epidemiology, researches focusing on the dose-effect association between acupuncture and diseases has also begun to emerge. So in this protocol, we designed to use a meta-regression approach to explore the optimal electroacupuncture dose for migraine.

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