Academic literature on the topic 'Stereocilin'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Stereocilin.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Stereocilin"
Avan, Paul, Sébastien Le Gal, Vincent Michel, Typhaine Dupont, Jean-Pierre Hardelin, Christine Petit, and Elisabeth Verpy. "Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane." Proceedings of the National Academy of Sciences 116, no. 51 (November 27, 2019): 25948–57. http://dx.doi.org/10.1073/pnas.1902781116.
Full textCartagena-Rivera, Alexander X., Sébastien Le Gal, Kerianne Richards, Elisabeth Verpy, and Richard S. Chadwick. "Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics." Science Advances 5, no. 2 (February 2019): eaat9934. http://dx.doi.org/10.1126/sciadv.aat9934.
Full textMandelker, Diana, Sami S. Amr, Trevor Pugh, Sivakumar Gowrisankar, Rimma Shakhbatyan, Elizabeth Duffy, Mark Bowser, et al. "Comprehensive Diagnostic Testing for Stereocilin." Journal of Molecular Diagnostics 16, no. 6 (November 2014): 639–47. http://dx.doi.org/10.1016/j.jmoldx.2014.06.003.
Full textVerpy, Elisabeth, Michel Leibovici, Nicolas Michalski, Richard J. Goodyear, Carine Houdon, Dominique Weil, Guy P. Richardson, and Christine Petit. "Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane." Journal of Comparative Neurology 519, no. 2 (December 16, 2010): 194–210. http://dx.doi.org/10.1002/cne.22509.
Full textHan, Woongsu, Jeong-Oh Shin, Ji-Hyun Ma, Hyehyun Min, Jinsei Jung, Jinu Lee, Un-Kyung Kim, et al. "Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells." Proceedings of the National Academy of Sciences 117, no. 20 (May 1, 2020): 11109–17. http://dx.doi.org/10.1073/pnas.1920229117.
Full textVerpy, Elisabeth, Dominique Weil, Michel Leibovici, Richard J. Goodyear, Ghislaine Hamard, Carine Houdon, Gaelle M. Lefèvre, et al. "Stereocilin-deficient mice reveal the origin of cochlear waveform distortions." Nature 456, no. 7219 (October 8, 2008): 255–58. http://dx.doi.org/10.1038/nature07380.
Full textFrykholm, Carina, Joakim Klar, Tatjana Tomanovic, Adam Ameur, and Niklas Dahl. "Stereocilin gene variants associated with episodic vertigo: expansion of the DFNB16 phenotype." European Journal of Human Genetics 26, no. 12 (September 24, 2018): 1871–74. http://dx.doi.org/10.1038/s41431-018-0256-6.
Full textPacentine, Itallia, Paroma Chatterjee, and Peter G. Barr-Gillespie. "Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle." International Journal of Molecular Sciences 21, no. 1 (January 3, 2020): 324. http://dx.doi.org/10.3390/ijms21010324.
Full textSathyanarayana, Bangalore K., Yoonsoo Hahn, Manish S. Patankar, Ira Pastan, and Byungkook Lee. "Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats." BMC Structural Biology 9, no. 1 (2009): 1. http://dx.doi.org/10.1186/1472-6807-9-1.
Full textAvenarius, Matthew R., Jocelyn F. Krey, Rachel A. Dumont, Clive P. Morgan, Connor B. Benson, Sarath Vijayakumar, Christopher L. Cunningham, et al. "Heterodimeric capping protein is required for stereocilia length and width regulation." Journal of Cell Biology 216, no. 11 (September 12, 2017): 3861–81. http://dx.doi.org/10.1083/jcb.201704171.
Full textDissertations / Theses on the topic "Stereocilin"
Iranfar, Sepideh. "AAV-mediated gene therapy restores hearing and central auditory processing in a mouse model of human DFNB16 Deafness." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS127.pdf.
Full textHearing impairment stands as a significant contributor to disability, affecting over half a billion individuals throughout their lifespans. Despite its pervasive prevalence, no curative treatment currently exists. My Ph.D. project is translational, aiming to establish the proof of concept that viral gene therapy can restore hearing in a preclinical model for DFNB16 deafness. DFNB16, considered the second most common cause of hearing impairment, is caused by mutations in the stereocilin (STRC) gene and is characterized by mild-to-moderate deafness. The stereocilin (STRC) protein is predominantly expressed in outer hair cells (OHCs), one of the two types of cochlear sensory hair cells, responsible for sound amplification. STRC protein is crucial for the cohesion and maintenance of OHC bundles. Mutations in STRC result in defective OHCs, leading to abolished cochlear amplification and subsequent reduction in hearing sensitivity. As of now, there exists no cure for DFNB16.My main objective was to develop an adeno-associated virus (AAV)-based gene therapy to replace the mutant gene with its correct copy in a DFNB16 mouse model. Given the large size of the Strc coding sequence, exceeding AAV packaging capacity, I employed a hybrid dual-vector strategy to load Strc cDNA into AAV capsids. Since OHCs are inherently difficult to transduce with AAV vectors, we firstly conducted a comparative analysis of AAV cellular tropism within the inner ear to identify the most efficient AAV serotype for targeting OHCs. Secondly, I used the best performing AAV serotype to construct the therapeutic vector, which was administered into the cochleas of DFNB16 mice.Following the gene therapy, we found a robust restoration of STRC protein expression and its appropriate targeting at the tips of OHC stereocilia in treated mice. This process results in the restoration of the normal morphostructure of OHC bundles and cochlear amplification, ensuring stable and long-lasting restoration of hearing in the treated mice, similar to those of the wild-type mice. Notably, psychometric measurements of frequency perception using a Go/NoGo task demonstrated that frequency discrimination exhibited by the treated Strc-/- mice was comparable to those of wild-type mice, underscoring the efficacy of gene therapy in recovering essential features of natural sound perception associated with DFNB16. This finding lays the foundation for effective translational gene therapy for DFNB16 patients and facilitates the development of preclinical gene therapy studies for mouse models of human deafness
Gomez, Salvador Gustavo. "Protein Phosphatase 1 Concentrates at the Base of Sensory Hair Cell Stereocilia, Where it May Function in Stereocilia Cytoskeletal Structure." Ohio University Art and Sciences Honors Theses / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1556276688823712.
Full textKitajiri, Shinichiro. "Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia." Kyoto University, 2005. http://hdl.handle.net/2433/144706.
Full textPeng, Anthony Wei. "A hair bundle proteomics approach to discovering actin regulatory proteins in inner ear stereocilia." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54588.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 137-154).
Because there is little knowledge in the areas of stereocilia development, maintenance, and function in the hearing system, I decided to pursue a proteomics-based approach to discover proteins that play a role in stereocilia function. I employed a modified "twist-off" technique to isolate hair bundle proteins, and I developed a method to purify proteins and to process them for analysis using multi-dimensional protein identification technology (MudPIT). The MudPIT analysis yielded a substantial list of proteins. I verified the presence of 21 out of 34 (62%) existing proteins known to be present in stereocilia. This provided strong evidence that my proteomics approach was efficient in identifying hair bundle proteins. Next, I selected three proteins and localized them to murine cochlear stereocilia. StarD10, a putative phospholipid binding protein, was detectable along the shaft of stereocilia. Nebulin, a putative F-actin regulator, was located toward the base of stereocilia. Finally, twinfilin 2, a putative modulator of actin polymerization, was found at the tips of stereocilia. In order to determine the function of twinfilin 2, I localized the protein predominately to the tips of shorter stereocilia where it is up-regulated during the final phase of elongation. When overexpressed, I found that twinfilin 2 causes a shortening of microvilli in LLC-PK1/CL4 cells and in native cochlear stereocilia. The main result of this thesis was determining the sub-cellular localization of three interesting proteins and functionally characterizing one protein. My thesis also confirmed the proteomics screen I developed as an efficient method for identifying proteins in stereocilia.
by Anthony Wei Peng.
Ph.D.
Shih-Wei, Chou. "FASCIN 2B IS A COMPONENT OF ZEBRAFISH STEREOCILIA AND A REGULATOR OF THEIR DIMENSIONS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1422016622.
Full textHu, Jiaqi. "TARGETING MECHANOTRANSDUCTION-RELATED GENES OF THE HAIR CELLUSING TALEN AND CRISPR/CAS TECHNOLOGY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417780489.
Full textHwang, Philsang. "An In Vivo Study of the Function and Dynamics of Stereociliary Proteins." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1418833642.
Full textKulkarni, Prateek. "Interaction of MYO6 and CLIC5: An Interdependent Relation in the Hair Bundle Maintenance." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1533730672111802.
Full textWaddell, Benjamin B. "CLIC5 maintains lifelong structural integrity of sensory stereocilia by promoting Radixin phosphorylation in hair cells of the inner ear." Ohio University Honors Tutorial College / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1461332124.
Full textHadi, Shadan. "MYOSIN-XVA IS KEY MOLECULE IN ESTABLISHING THE ARCHITECTURE OF MECHANOSENSORY STEREOCILIA BUNDLES OF THE INNER EAR HAIR CELLS." UKnowledge, 2018. https://uknowledge.uky.edu/medsci_etds/9.
Full textBooks on the topic "Stereocilin"
Canlon, Barbara. The effect of acoustic trauma on the tectorial membrane, stereocilia, and hearing sensitivity: Possible mechanisms underlying damage, recovery, and protection. Stockholm, Sweden: Distributed by Almqvist & Wiksell Periodical Co., 1988.
Find full textBook chapters on the topic "Stereocilin"
Kita, Tomoko, Tatsuya Katsuno, and Shin-ichiro Kitajiri. "Stereocilia." In Regenerative Medicine for the Inner Ear, 31–38. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54862-1_4.
Full textWatson, Glen M., and Patricia Mire. "Stereocilia Based Mechanoreceptors of Sea Anemones." In Cell and Molecular Biology of the Ear, 19–39. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4223-0_2.
Full textPeng, Anthony W., and Anthony J. Ricci. "Glass Probe Stimulation of Hair Cell Stereocilia." In Methods in Molecular Biology, 487–500. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3615-1_27.
Full textEngstrom, B., E. Borg, and B. Canlon. "Morphology of Stereocilia on Cochlear Hair Cells after Noise Exposure." In Basic and Applied Aspects of Noise-Induced Hearing Loss, 1–9. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5176-4_1.
Full textSaunders, James C., Barbara Canlon, and Ake Flock. "Mechanical Changes in Stereocilia Following Overstimulation: Observations and Possible Mechanisms." In Basic and Applied Aspects of Noise-Induced Hearing Loss, 11–29. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5176-4_2.
Full textSatarić, Miljko, and Tomas Nemeš. "Calcium Signaling Along Actin Filaments in Stereocilia Controls Hair-Bundle Motility." In Nonlinear Dynamics of Nanobiophysics, 307–44. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-5323-1_11.
Full textRichardson, G. P., I. J. Russell, R. Wasserkort, and M. Hans. "Aminoglycoside Antibiotics and Lectins Cause Irreversible Increases in the Stiffness of Cochlear Hair-Cell Stereocilia." In Cochlear Mechanisms: Structure, Function, and Models, 57–65. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5640-0_7.
Full textVélez-Ortega, A. Catalina, and Gregory I. Frolenkov. "Visualization of Live Cochlear Stereocilia at a Nanoscale Resolution Using Hopping Probe Ion Conductance Microscopy." In Methods in Molecular Biology, 203–21. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3615-1_12.
Full textPickles, J. O., S. D. Comis, and M. P. Osborne. "The Morphology of Stereocilia and their Cross-Links in Relation to Noise Damage in the Guinea Pig." In Basic and Applied Aspects of Noise-Induced Hearing Loss, 31–41. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5176-4_3.
Full textHorner, K. C., Y. Cazals, and A. Guilhaume. "Round Window Cochlear Microphonic and Atrophy of Short and Middle Stereocilia on Outer Hair Cells in Hydropic Cochleas in Guinea Pigs." In Cochlear Mechanisms: Structure, Function, and Models, 207–15. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5640-0_26.
Full textConference papers on the topic "Stereocilin"
Smith, Sonya T., and Richard Chadwick. "Nanofluidics of Mammalian Hearing." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-64729.
Full textHACKNEY, C. M., B. WEST, and D. N. FURNESS. "THE COMPOSITION OF LINKAGES BETWEEN STEREOCILIA." In Proceedings of the International Symposium. WORLD SCIENTIFIC, 2000. http://dx.doi.org/10.1142/9789812793980_0043.
Full textVandaele, Mathieu, Bryan S. Joyce, and Pablo A. Tarazaga. "Design and Characterization of Piezo-Based Stereocilia." In ASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/smasis2013-3189.
Full textThumati, Balaje T., D. Subbaram Naidu, and Larry Stout. "A Neuro-Fuzzy Model for Simulating Outer Hair Cell of Human Cochlea." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80644.
Full textBathe, Mark, Claus Heussinger, Mireille Claessens, Andreas Bausch, and Erwin Frey. "Cytoskeletal Bundle Mechanics." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176170.
Full textGUETA, R., D. BARLAM, R. Z. SHNECK, and I. ROUSSO. "THE ANISOTROPY OF THE TECTORIAL MEMBRANE GUIDES STEREOCILIA DEFLECTION." In Proceedings of the 10th International Workshop on the Mechanics of Hearing. WORLD SCIENTIFIC, 2009. http://dx.doi.org/10.1142/9789812833785_0040.
Full textLANGER, M. G., S. FINK, K. LÖFFLER, A. KOITSCHEV, and H. P. ZENNER. "INVESTIGATION OF THE MECHANOELECTRICAL TRANSDUCTION AT SINGLE STEREOCILIA BY AFM." In Proceedings of the International Symposium. WORLD SCIENTIFIC, 2003. http://dx.doi.org/10.1142/9789812704931_0005.
Full textCHIARADIA, CAIO, MANUELA NOWOTNY, and ANTHONY W. GUMMER. "DEFLECTION OF IHC STEREOCILIA IN RESPONSE TO SOMATIC OHC ELECTROMOTILITY." In Proceedings of the 10th International Workshop on the Mechanics of Hearing. WORLD SCIENTIFIC, 2009. http://dx.doi.org/10.1142/9789812833785_0044.
Full textMaftoon, Nima, Hamid Motallebzadeh, John J. Guinan, and Sunil Puria. "Drive mechanisms to the inner and outer hair cell stereocilia." In TO THE EAR AND BACK AGAIN - ADVANCES IN AUDITORY BIOPHYSICS: Proceedings of the 13th Mechanics of Hearing Workshop. Author(s), 2018. http://dx.doi.org/10.1063/1.5038510.
Full textAltoè, Alessandro, and Ville Pulkki. "Deriving stereocilia displacement from the impedance of the organ of Corti." In MECHANICS OF HEARING: PROTEIN TO PERCEPTION: Proceedings of the 12th International Workshop on the Mechanics of Hearing. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4939328.
Full textReports on the topic "Stereocilin"
Yazdidoust, Ladan. Defining Protein Interactions: Ankle Link Proteins of Stereocilia in Hair Cells. Portland State University Library, January 2016. http://dx.doi.org/10.15760/honors.276.
Full text