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Journal articles on the topic 'Stemmless'

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Published: 23 November 2024

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1

Mennel, Barbara. "Race under Reconstruction in German Cinema: Robert Stemmle’s Toxis (review)." German Studies Review 35, no. 2 (May 2012): 439–41. http://dx.doi.org/10.1353/gsr.2012.a478079.

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2

Sayce, Olive. "Stemmler, T. ed., Natur und Lyrik." Notes and Queries 39, no. 2 (June 1, 1992): 205–7. http://dx.doi.org/10.1093/nq/39.2.205.

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3

Lang, Stefan, and Rudolf Seigel. "Rezension von: Seigel, Rudolf u.a. (Bearb.), Die Urkunden des Stifts Buchau." Ulm und Oberschwaben 56 (July 19, 2023): 309–10. http://dx.doi.org/10.53458/uo.v56i.6999.

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Die Urkunden des Stifts Buchau. Regesten 819-1500 (Inventare der nichtstaatlichen Archive in Baden-Württemberg 36). Bearb. von Rudolf Seigel, Eugen Stemmler (†) und Bernhard Theil. Stuttgart: W. Kohlhammer Verlag 2009; 728 S., 25 Abb., 56,- EUR
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4

Wrobbel, Sibylle, Rudolf Seigel, Eugen Hermann Stemmler, and Bernhard Theil. "Rezension von: Seigel, Rudolf; Stemmler, Eugen; Theil, Bernhard (Bearb.), Die Urkunden des Stifts Buchau." Schwäbische Heimat 60, no. 4 (July 5, 2022): 514–15. http://dx.doi.org/10.53458/sh.v60i4.3258.

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Rudolf Seigel, Eugen Stemmler und Bernhard Theil (Bearb.): Die Urkunden des Stifts Buchau. Regesten 819 – 1500. (Inventare der nichtstaatlichen Archive in Baden-Württemberg, Band 36). W. Kohlhammer Verlag Stuttgart 2009. 728 Seiten mit 25 Abbildungen. Pappband € 56,–. ISBN 978-3-17-020783-7
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5

Winstead, Antoinette. "A Review of “Race Under Reconstruction in German Cinema: Robert Stemmle's Toxi”." Quarterly Review of Film and Video 29, no. 2 (March 2012): 184–89. http://dx.doi.org/10.1080/10509208.2011.646569.

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6

Journal, Baghdad Science. "Morphological and Histological study of pancreas in (Saw-scaled viper) Echis carinatus scochureki (Stemmler,1969)." Baghdad Science Journal 12, no. 2 (June 7, 2015): 249–59. http://dx.doi.org/10.21123/bsj.12.2.249-259.

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The aims of study were identify the Morphological description and histological structure of pancreas gland in the Saw-scaled viper snake, (Echis carinatus scochureki). The study was conducted on 6 snakes collected from the city of Nasiriya in Dhi Qar province, Doped snakes was dissected to isolate the pancreas gland, and the histological slides prepared after samples fixation by fixative solutions, the routine stains Haematoxylin– Eosin were used. Morphological Description study showed that the pancreas gland was compact in type with one lobe, white-pink in colure. The pancreas Located at the level of the Gall bladder associated with it’s caudal side, The spleen is adjacent to pancreas completely in the dorsal side .and duodenum linked to pancreas in the ventral side. The pancreas is mixed gland (endocrine and exocrine) surrounded by a capsule which extends trabeculae with blood vessels inside the gland. The exocrine part represent by the acini which were consisted of pyramidal cells with basal spherical nuclei, attached with each other forming a lumen in the center of the acinus penetrated by centro-acinar cells (flat epithelial cells) Opening in intercalated duct which lined by simple squamous epithelial Tissue, leading to intralobular duct then to interlobular ducts, both lined by simple cuboidal epithelial tissue these ducts leading to the main pancreatic duct which Lined by Ciliated columnar epithelium, as well as, interlobular and Main ducts surrounded by dense connective tissue, While The endocrine part of the pancreas is represented by islets of Langerhans Scattered in the peripheral part of the stroma, varied in forms : Rounded, Oval, and Irregular in shape, also varied in their sizes: small, medium and large. Saw-scaled viper snake had giant islets prevalent in the region adjacent to the spleen.
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7

Ibrahem, Wejdan H., and Gazwa D. Al–Nakeeb. "Morphological and Histological study of pancreas in (Saw-scaled viper) Echis carinatus scochureki (Stemmler,1969)." Baghdad Science Journal 12, no. 2 (June 7, 2015): 249–59. http://dx.doi.org/10.21123/bsj.2015.12.2.249-259.

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The aims of study were identify the Morphological description and histological structure of pancreas gland in the Saw-scaled viper snake, (Echis carinatus scochureki). The study was conducted on 6 snakes collected from the city of Nasiriya in Dhi Qar province, Doped snakes was dissected to isolate the pancreas gland, and the histological slides prepared after samples fixation by fixative solutions, the routine stains Haematoxylin– Eosin were used. Morphological Description study showed that the pancreas gland was compact in type with one lobe, white-pink in colure. The pancreas Located at the level of the Gall bladder associated with it’s caudal side, The spleen is adjacent to pancreas completely in the dorsal side .and duodenum linked to pancreas in the ventral side. The pancreas is mixed gland (endocrine and exocrine) surrounded by a capsule which extends trabeculae with blood vessels inside the gland. The exocrine part represent by the acini which were consisted of pyramidal cells with basal spherical nuclei, attached with each other forming a lumen in the center of the acinus penetrated by centro-acinar cells (flat epithelial cells) Opening in intercalated duct which lined by simple squamous epithelial Tissue, leading to intralobular duct then to interlobular ducts, both lined by simple cuboidal epithelial tissue these ducts leading to the main pancreatic duct which Lined by Ciliated columnar epithelium, as well as, interlobular and Main ducts surrounded by dense connective tissue, While The endocrine part of the pancreas is represented by islets of Langerhans Scattered in the peripheral part of the stroma, varied in forms : Rounded, Oval, and Irregular in shape, also varied in their sizes: small, medium and large. Saw-scaled viper snake had giant islets prevalent in the region adjacent to the spleen.
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8

Luiselli, James K. "Michael Potegal, Gerhard Stemmler, and Charles Spielberger: International Handbook of Anger: Constituent and Concomitant Biological, Psychological, and Social Processes." Journal of Child and Family Studies 20, no. 4 (April 7, 2011): 542–43. http://dx.doi.org/10.1007/s10826-011-9475-y.

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9

Pavlishchuk, Anna, Dina Naumova, Matthias Zeller, Sebastian Calderon Cazorla, and Anthony W. Addison. "The crystal structures of {LnCu5}3+ (Ln = Gd, Dy and Ho) 15-metallacrown-5 complexes and a reevaluation of the isotypic EuIII analogue." Acta Crystallographica Section E Crystallographic Communications 75, no. 8 (July 19, 2019): 1215–23. http://dx.doi.org/10.1107/s205698901900999x.

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Three new isotypic heteropolynuclear complexes, namely pentaaquacarbonatopentakis(glycinehydroxamato)nitratopentacopper(II)lanthanide(III) x-hydrate, [LnCu5(GlyHA)5(CO3)(NO3)(H2O)5]·xH2O (GlyHA2− is glycinehydroxamate, N-hydroxyglycinamidate or aminoacetohydroxamate, C2H4N2O2 2−), with lanthanide(III) (Ln III) = gadolinium (Gd, 1, x = 3.5), dysprosium (Dy, 2, x = 3.28) and holmium (Ho, 3, x = 3.445), within a 15-metallacrown-5 class were obtained on reaction of lanthanide(III) nitrate, copper(II) acetate and sodium glycinehydroxamate. Complexes 1–3 contain five copper(II) ions and five bridging GlyHA2− anions, forming a [CuGlyHA]5 metallamacrocyclic core. The Ln III ions are coordinated to the metallamacrocycle through five O-donor hydroxamates. The electroneutrality of complexes 1–3 is achieved by a bidentate carbonate anion coordinated to the Ln III ion and a monodentate nitrate anion coordinated apically to one of the copper(II) ions of the metallamacrocycle. The lattice parameters of complexes 1–3 are similar to those previously reported for an EuIII–CuII 15-metallacrown-5 complex with glycinehydroxamate of proposed composition [EuCu5(GlyHA)5(OH)(NO3)2(H2O)4]·3.5H2O [Stemmler et al. (1999). Inorg. Chem. 38, 2807–2817]. High-quality X-ray data obtained for 1–3 have allowed a re-evaluation of the X-ray data solution proposed earlier for the EuCu5 complex and suggest that the formula is actually [EuCu5(GlyHA)5(CO3)(NO3)(H2O)5]·3.5H2O.
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10

Zerbe, Stefan. "Teaching applied landscape ecology in interdisciplinary and intercultural student groups. Experiences from a 10-years study abroad program." Landscape Online 81 (September 15, 2020): 1–15. http://dx.doi.org/10.3097/lo.202081.

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Against the background of the global environmental crises, landscape ecology and related disciplines become increasingly important. Higher education should therefore contribute to the development of experts and potential stakeholders who have not only scientific skills but also interdisciplinary, intercultural, and communication skills to be applied in diverse contexts throughout the world. A 10-years program, funded by the Stemmler Foundation within the German Stifterverband supported studies abroad with excursions, summer schools, and workshops with students from the Bachelor, Master and doctoral level of various study programs. Students from 39 countries from all over the world benefitted from this program. In summer schools, particularly ecosystem restoration and nature conservation were addressed in lectures and during field trips as well as with students’ input of case studies from their country of origin. During international excursions to various countries, land use and culture, land-use history, and sustainable development were topics, with close interaction with local land users and stakeholders. Bridging the natural with the social sciences was achieved by involving respective experts as well as stimulate students to cross-disciplinary thinking and judgements. Master students were offered exploratory learning environments abroad within ongoing landscape ecological research projects for their thesis. Students’ feedback reflect an overall successful approach, which prepared students for the global environmental challenges with hard and soft skills.
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11

Wieling, Hans. "Mos maiorum. Untersuchungen zu den Formen der Identitätsstiftung und Stabilisierung in der römischen Republik, hg. v. Bernhard Linke/Michael Stemmler." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte. Romanistische Abteilung 119, no. 1 (August 1, 2002): 635–38. http://dx.doi.org/10.7767/zrgra.2002.119.1.635.

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12

Zuckerman, Marvin. "Still another failure of arousal theory: A critique of “personality, situation and physiological arousability” by G. Stemmler and E. Meinhardt." Personality and Individual Differences 11, no. 3 (January 1990): 309–12. http://dx.doi.org/10.1016/0191-8869(90)90244-l.

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13

Ben-Shakhar, Gershon. "The Correction of Psychophysiological Measures for Individual Differences in Responsivity Should Be Based on Typical Response Parameters: A Reply to Stemmler." Psychophysiology 24, no. 2 (March 1987): 247–49. http://dx.doi.org/10.1111/j.1469-8986.1987.tb00287.x.

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14

Tončić, Marko. "Ličnost i reakcija na iznenadni događaj." Psihologijske teme 29, no. 3 (2020): 729–51. http://dx.doi.org/10.31820/pt.29.3.12.

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Cilj je ovoga istraživanja bio ispitati interindividualne razlike u elektrodermalnim reakcijama na iznenadni podražaj. Za ispitivanje toga cilja korištene su različite metode procjene elektrodermalne reakcije. Procjena reakcije kao jednostavna razlika prosječne elektrodermalne razine prije i poslije podražaja uspoređena je s pristupima koji modeliraju krivulju elektrodermalne reakcije kroz vrijeme. Ispitana je povezanost takve reakcije, modelirane na različite načine, s upitničkim mjerama osobina ličnosti. U istraživanju je sudjelovalo 97 studenata u dobi od 18 do 28 godina, većinom ženskoga spola (60 %). Svaki je ispitanik ispunio kratku mjeru neuroticizma i ekstraverzije iz Petofaktorskoga inventara ličnosti (BFI; John i sur., 1991, 2008) te je sudjelovao u jednome laboratorijskome mjerenju elektrodermalne reakcije na iznenadni događaj u trajanju od 8 minuta. Elektrodermalna aktivnost modelirala se na tri načina: 1) kao razlika u reakcijama prije i poslije podražaja; 2) uključujući i linearne efekte vremena; 3) uključujući i kvadratne efekte vremena. Ishodi takvoga modeliranja korelirani su s upitničkim mjerama neuroticizma i ekstraverzije. Rezultati su pokazali da uzimajući u obzir efekte protoka vremena sama procjena krivulje elektrodermalne aktivnosti značajno bolje pristaje stvarnim izmjerenim podacima. Isto tako, procjene elektrodermalne reakcije koje uzimaju u obzir efekte protoka vremena rezultiraju višim prosječnim razinama i većim interindividualnim varijabilitetom. Tako modelirana elektrodermalna reakcija (linearno i kvadratno) pokazuje nešto blago više i značajne pozitivne korelacije s neuroticizmom, iako su razlike između različitih načina modeliranja relativno male. Dobiveni rezultati podupiru ideju o većoj pobudljivosti vezanoj uz crtu neuroticizma. Iako su korelacije iznimno male, ne odstupaju od onih dobivenih u drugim istraživanjima, pogotovo jer je riječ o jednome mjerenju (Stemmler i Wacker, 2010). S obzirom na intenzitet reakcije, moguće je da pobudljivost vezana uz neuroticizam i nije specifično vezana za valenciju podražaja koji tu reakciju pobuđuje. Rezultati također pokazuju da se i na malome uzorku i korištenjem samo jednoga mjerenja, uz adekvatno modeliranje elektrodermalne aktivnosti, može detektirati povezanosti s osobinama ličnosti.
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15

Rhadi, Fadhel Aabbas, Rihab Ghaleb Mohammed, Nasrullah Rastegar-Pouyani, Eskandar Rastegar-Pouyani, and Seyyed Saeed Hosseinian Yousefkhani. "On the Snake Fauna of Central and Southern Iraq and Some Zoogeographic Remarks." Russian Journal of Herpetology 24, no. 4 (June 26, 2017): 251–66. http://dx.doi.org/10.30906/1026-2296-2017-24-4-251-266.

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Central and southern Iraq in the area adjacent to and between the Tigris and Euphrates rivers, known as Mesopotamian plain. The Mesopotamian plain is a geological depression filled with rivers sediments which covers the central and southern part of Iraq. It is plain of the Tigris and Euphrates rivers, beings north of Baghdad and extends to southern Iraq, bordered by High Mountain in the east, desert from the west, and Persian Gulf from the south. An area of diverse physical features leading to rich biodiversity. An investigation of the status of snakes in central and southern Iraq was carried out from September 2013 to May 2015. A total of 138 specimens were collected and identified. Five families, 13 genera, and 17 species are represented, including Lyptotyphlopidae: Lyptotyphlops macrorhyncha (Jan, 1861); Boidae: Eryx jaculus jaculus (Linnaeus, 1758), Eryx jaculus familiaris Eichwald, 1831, Eryx cf. miliaris (Pallas, 1773); Lamprophiidae: Psammophis schokari (Forsskål, 1775), Malpolon insignitus (Geoffroy Saint-Hilaire, 1827), Rhagerhis moilensis (Reuss, 1834); Colubridae: Dolichophis cf. caspius (Gmelin, 1789), Dolichophis jugularis (Linnaeus 1785), Dolichophis cf. schmidti (Nikolsky, 1909), Spalerosophis diadema cliffordi (Schlegel, 1837), Platyceps ventromaculatus (Gray, 1834), Natrix tessellata (Laurenti, 1768); and Viperidae: Pseudocerastes persicus fieldi K. Schmidt, 1930, Macrovipera lebetina (Linnaeus, 1758), Cerastes gasperettii gasperettii Leviton et Anderson, 1967, and Echis carinatus Stemmler, 1969. According to the literature, 41 species of snakes were found in Iraq and according to the results of this survey 17 species and subspecies (~41%) of them occur in central and southern Iraq. Of these, 10 species are aglypha, 3 species opisthoglypha and 4 species proteroglypha. This study was conducted in 27 sampling localities and these project areas represent typical environment and climate of the central and southern regions of Iraq.
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Baerwald, C., E. Stemmler, S. Gnuechtel, K. Jeromin, C. Holland, B. Fritz, D. Adolf, P. C. Taylor, and R. Baron. "POS0598 PERSISTING PAIN IN RHEUMATOID ARTHRITIS: DO WE NEED TO RECONSIDER OUR IDEA OF PAIN ALLEVIATION DESPITE ANTI-INFLAMMATORY TREATMENT?" Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 566–67. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2152.

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BackgroundPain significantly impacts life of patients with rheumatoid arthritis (RA) (1). Besides articular pain due to systemic inflammation, neuropathic pain (NeP) represents another challenge that can pose a considerable burden on the life of patients (2).ObjectivesTo investigate persisting pain in RA patients and to analyse NeP along with patient-reported outcomes (PROs).MethodsPAIN-CONTROL is a prospective, non-interventional study in rheumatology centres in Germany. Inclusion criteria were fulfilment of the 2010 ACR/EULAR RA classification criteria, disease duration ≤ 8 yrs, DAS28 > 3.2, SJC > 3, CRP normal or above reference range, and pain rating ≥ 50 (0-100 VAS). Eligible subjects had to be scheduled for escalation of anti-inflammatory treatment according to national guidelines. At wk 24 subjects were allocated to three subgroups given DAS28-CRP change and VAS pain: i) reference group: VAS pain < 50 with either DAS28 improvement > 1.2 or DAS28 ≤ 3.2, ii) non-responders: DAS28 improvement ≤ 1.2 and DAS28 > 3.2 with or without pain alleviation, iii) persisting pain: VAS pain ≥ 50 with either DAS28 improvement > 1.2 or DAS28 ≤ 3.2. For groups 1 and 2 end of study was at week 24, patients with persisting pain continued until wk 48. Patients were assessed for NeP using a score of ≥ 19 in the painDETECT questionnaire (PD-Q) (3). Pain-related PROs, i.e. the Rheumatoid Arthritis Impact of Disease Questionnaire (RAID) and the Patient Health Questionnaire (PHQ-9), were analysed along with demographic background information (1,4). Descriptive results are presented as mean (SD) or mean (SD) | Nvalid, as well as n (%) or n (%) | Nvalid, respectively.Results567 subjects were analysed with the following distribution: Reference group 337 (59.4%), non-responders 102 (18.0%), and persisting pain 128 (22.6%), of which 115 patients were available at wk 48. Subgroups showed similar demographic baseline characteristics but differed in PROs (Table 1). Until wk 24, proportion of patients with NeP indication decreased in the reference group (-19.8%) and slightly in non-responders (-6.0%) and persisting pain group (-9.5%). Non-responders showed the highest NeP proportion at wk 24 (35.0%) (Table 1). Of 115 patients with persisting pain at wk 24, 47 (40.9%) tested NeP negative at wk 48, 21 (18.3%) tested unclear, 28 (24.3%) were missing and 19 (16.5%) tested positive. Of the latter 9 patients (47.4%) still had persisting pain at week 48, while this was the case for 14 patients (29.8%) in the former group. 49 (42.6%) of 115 patients with severe persisting pain at wk 24 reported pain alleviation at wk 48 and fulfillment of reference group criteria. RAID and PHQ-9 scores improved in the reference group but only slightly in the other two subgroups.Table 1.Demographic background and PROsCharacteristicReference group(N = 337)Non-responders(N = 102)Persisting pain(N = 128)Gender (f/m)233 (69.1%) /65 (63.7%) /87 (68.0%) /104 (30.9%)37 (36.3%)41 (32.0%)Age57.1 (13.2) | 33759.9 (12.0) | 10257.1 (13.0) | 128Disease duration (yrs)2.5 (2.6) | 3372.7 (2.8) | 1022.5 (2.5) | 128PD-Q (≥ 19) (Bl)82 (28.6%) | 28732 (41.0%) | 7840 (36.0%) | 111PD-Q (≥ 19) (wk 24)21 (8.8%) | 23928 (35.0%) | 8027 (26.5%) | 102PD-Q (Bl)14.0 (6.8) | 28715.5 (7.1) | 7815.5 (6.5) | 111PD-Q (wk 24)8.8 (5.8) | 23914.8 (6.7) | 8013.8 (7.2) | 102RAID (Bl)5.8 (2.0) | 3326.0 (1.9) | 1006.6 (1.7) | 125RAID (wk 24)2.4 (1.8) | 3215.4 (1.9) | 975.1 (1.9) | 123PHQ-9 (Bl)7.3 (5.1) | 3288.4 (5.4) | 987.9 (5.1) | 123PHQ-9 (wk 24)3.8 (3.5) | 3187.3 (4.5) | 956.6 (4.5) | 122ConclusionNeP is common among RA non-responders to anti-inflammatory treatment and in patients with persisting pain, meriting a routine NeP screening to more adequately address persisting pain in these patients. However, even late improvements (after 24 wks) regarding persisting pain seem likely during anti-inflammatory treatment.References[1]Gossec L, Ann Rheum Dis. 2011 Jun;70(6):935–42.[2]Noda K, Mod Rheumatol. 2020 Sep;30(5):828–34.[3]Freynhagen R, Curr Med Res Opin. 2006 Oct;22(10):1911–20.[4]Kroenke K, J Gen Intern Med. 2001 Sep;16(9):606–13.AcknowledgementsStatistical analysis was provided under lead of Dr. Daniela Adolf of StatConsult GmbH, which was funded by AbbVie.Medical writing support was provided by Dr. Matthias Englbrecht of Statscoach, which was funded by AbbVie.Disclosure of InterestsChristoph Baerwald Speakers bureau: Prof. Christoph G. Baerwald has served as consultant to AbbVie and has received research funding and speaker fees from AbbVie., Consultant of: Prof. Christoph G. Baerwald has served as consultant to AbbVie and has received research funding and speaker fees from AbbVie., Grant/research support from: Prof. Christoph G. Baerwald has served as consultant to AbbVie and has received research funding and speaker fees from AbbVie., Edgar Stemmler Shareholder of: Dr. Edgar Stemmler is employee of AbbVie and may own AbbVie stock., Employee of: Dr. Edgar Stemmler is employee of AbbVie and may own AbbVie stock., Sixten Gnuechtel Shareholder of: Dr. Sixten Gnüchtel is employee of AbbVie and may own AbbVie stock., Employee of: Dr. Sixten Gnüchtel is employee of AbbVie and may own AbbVie stock., Katharina Jeromin Shareholder of: Dr. Katharina Jeromin is employee of AbbVie and may own AbbVie stock, Employee of: Dr. Katharina Jeromin is employee of AbbVie and may own AbbVie stock, Carsten Holland Shareholder of: Dr. Carsten Holland is employee of AbbVie and may own AbbVie stock, Employee of: Dr. Carsten Holland is employee of AbbVie and may own AbbVie stock, björn fritz Shareholder of: Dr. Björn Fritz is employee of AbbVie and may own AbbVie stock., Employee of: Dr. Björn Fritz is employee of AbbVie and may own AbbVie stock., Daniela Adolf Consultant of: Dr. Daniela Adolf is an employee of StatConsult GmbH.Statistical analysis was provided under lead of Dr. Daniela Adolf of StatConsult GmbH, which was funded by AbbVie, Peter C. Taylor Speakers bureau: Peter C. Taylor has served as consultant to AbbVie and has received speaker fees from AbbVie, Consultant of: Peter C. Taylor has served as consultant to AbbVie and has received speaker fees from AbbVie, Ralf Baron Speakers bureau: Prof. Ralf Baron has served as consultant to AbbVie and has received speaker fees from AbbVie., Consultant of: Prof. Ralf Baron has served as consultant to AbbVie and has received speaker fees from AbbVie.
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de Chambrier, Alain, Philippe V. Alves, Rolf K. Schuster, and Tomáš Scholz. "Ophiotaenia echidis n. sp. (Cestoda: Proteocephalidae) from the saw-scaled viper, Echis carinatus sochureki Stemmler (Ophidia: Viperidae), one of the world's deadliest snakes, from the United Arab Emirates." International Journal for Parasitology: Parasites and Wildlife 14 (April 2021): 341–54. http://dx.doi.org/10.1016/j.ijppaw.2021.03.006.

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18

Bücklein, V., V. Blumenberg, C. Schmidt, K. Rejeski, M. Ruzicka, N. Müller, A. Reischer, et al. "P07.01 CD19 CAR T-cells for relapsed/refractory diffuse large B-cell Lymphoma: real-world data from LMU Munich." Journal for ImmunoTherapy of Cancer 8, Suppl 2 (October 2020): A48.2—A49. http://dx.doi.org/10.1136/jitc-2020-itoc7.95.

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BackgroundThe anti-CD19 CAR T-cell products Axicabtagene Ciloleucel (Axi-cel) and Tisagenlecleucel have been approved by the EMA for the treatment of patients (pts) with relapse/refractory (r/r) diffuse large B-cell lymphoma (DLBCL) in August 2018. In clinical trials, both cell products induced ongoing complete responses in heavily pretreated patients. However, this activity was associated with significant toxicity. We evaluated the outcomes of DLBCL pts treated with Axi-cel and Tisagenlecleucel at the LMU Munich.Materials and MethodsCAR T cell product characteristics, toxicity and response rates of pts treated at our center between January and October 2019 were retrospectively assessed.ResultsAs of October 2019, 24 out of 34 r/r DLBCL pts (71%) with confirmed CAR T cell treatment indication were leukapheresed. Four apheresed pts died before CAR T cell therapy due to rapidly progressive disease. So far, 17 DLBCL pts have been treated. Median age was 60 years (range 19–74). ECOG was 0–1 in eleven, and 2–3 in six pts. Eight pts had undergone prior stem cell transplant (6 autologous, 2 allogeneic SCT). 13 pts received bridging chemotherapy between leukapheresis and CAR T cell transfusion. Only 6 (35%) of the 17 transfused pts would have met the inclusion criteria of the pivotal clinical trials (JULIET, ZUMA-1).CRS occurred in all pts (53% CRS °1, 29% °2 and 18% °3) with a median onset on day 2 (range days 0–7) and a median duration of 4 days (range 1–21). Tocilizumab was administered at least once in all pts. Ten pts (59%) experienced Immune Effector Cell associated Neurotoxicity Syndrome (ICANS, 30% °1, 10% °2, 30% °3, 20% °4 and 10% °5) with a median onset between day 7 and 8 and a median duration of 8 days (range 3–49). Cytopenia was significant following CAR T-cell treatment: all but one pts had neutropenia <500/µl for more than seven days.Response assessment four weeks after CAR T-cell transfusion was available for 15 pts.Objective response rate (ORR) at this early follow-up was 67%, with complete remission (CR) in four (27%) and partial remission (PR) in six pts (40%). Interestingly, ORR was higher in the four pts not receiving bridging chemotherapy between leukapheresis and CAR T-cell therapy than in pts in which bridging was applied (100% vs. 55%). Responders had significantly higher LDH levels at apheresis, start of lymphodepletion and CAR T-cell transfusion than non-responders.ConclusionsSince January 2019, the CAR T cell program has been successfully initiated at the LMU Munich, and 17 r/r DLBCL pts have been treated at our center to date. CAR T cells induced responses in heavily pretreated pts with response rates within the expected range. Toxicity was significant but manageable in most pts. Involvement of a multidisciplinary ImmunoTaskforce was a key element for adequate patient care. Preliminary data supports the hypothesis that low tumor dynamics are associated with favorable outcomes of CD19 CAR T cell therapy.Disclosure InformationV. Bücklein: None. V. Blumenberg: None. C. Schmidt: None. K. Rejeski: None. M. Ruzicka: None. N. Müller: None. A. Reischer: None. L. von Baumgarten: None. A. Völkl: None. B. Wagner: None. A. Humpe: None. J. Tischer: None. H. Stemmler: None. M. von Bergwelt: None. M. Subklewe: None.
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Kemenes, S., K. Tascilar, A. Kleyer, I. Minopoulou, F. Fagni, A. Zekovic, C. A. Isnardi, et al. "POS0156 BONE DENSITY, MICROSTRUCTURE AND BIOMECHANICS OVER A 7-YEAR OBSERVATION PERIOD IN RHEUMATOID ARTHRITIS AND PSORIATIC ARTHRITIS - INFLUENCE OF AUTOIMMUNITY, DISEASE ACTIVITY AND BIOLOGICAL DMARD TREATMENT." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 300–301. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1612.

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BackgroundRheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) are characterized by a deterioration of bone mass, bone microstructure and biomechanics [1, 2]. However, little evidence is available on the long-term evolution of these bone properties and the impact of autoimmunity, disease activity and targeted anti-inflammatory therapy.ObjectivesTo evaluate the longitudinal course of peripheral volumetric bone mineral density (vBMD), microstructure and biomechanics in patients with seropositive RA (RA+), seronegative RA (RA-) and PsA (i) by diagnosis (ii) disease activity and (iii) ever use of biologic/targeted synthetic (b/ts) DMARDs.MethodsRA+, RA-, PsA patients who had at least one high-resolution CT scan were included. Prospectively collected longitudinal data from the distal radius. vBMD, microstructure and biomechanical properties were assessed and data on treatments and disease activity (DAS-28) were collected. We described and summarized the time course of these measurements, using linear regression models as age and sex adjusted time-conditional means and mean differences by disease category, time-varying weighted average disease activity and intervening b/tsDMARD treatments.ResultsWe analyzed 946 scans from 412 patients (193 RA+, 68 RA-, 151 PsA) with a median CT follow-up duration of 24 months (IQR 0 to 47). (Table 1). Overall, bone quality showed a downward course over time. RA+ patients showed lower total and trabecular bone densities compared to patients with psoriatic arthritis throughout the time course. (Figure 1a). RA+ patients also showed decreasing trabecular number with increasing trabecular thickness, trabecular irregularity and trabecular separation over time in comparison to PsA (Figure 1 b) suggesting a gradual disappearance of the thinner trabeculae. We detected significant time/DAS-28 interactions in PSA patients indicating faster cortical bone loss over time with increasing DAS-28 (p interaction =0.049), in RA- patients showing faster trabecular bone loss over time with higher disease activity (p.interaction 0.044) and in RA+ patients for trabecular density (p interaction 0.038), bone stiffness (p interaction 0.022) and failure load (p interaction 0.034) indicating a faster deterioration of bone quality over time with increasing disease activity. Interestingly, RA+ patients exposed to b/tsDMARDs had numerically lower bone density compared to unexposed patients, whereas the temporal pattern suggested a more stable vBMD over time as opposed to a deteriorating pattern in the unexposed. However, the uncertainty in these analyses was large and none of the time-exposure interactions or pairwise differences over time between ever vs. never exposed categories were significant.ConclusionAutoimmunity impairs bone health over time and is particularly associated with impaired trabecular bone quality. Good control of disease activity in RA+, RA-, and PsA patients may be helpful in preventing bone loss and deterioration of bone microstructure, and biomechanics. Specific contribution of b/tsDMARDs to the time course of bone quality at the radius needs further clarification.References[1]Kocijan R et al. J Bone Miner Res 2015[2]Stemmler F et al. Ann Rheum Dis 2018Table 1.Patient characteristicsDiagnosisPsARA seronegativeRA seropositiveN15168193Age, years, mean (SD)51.7 (12.2)58.8 (12.2)53.9 (12.5)Females, n(%)72 (47.7)49 (72.1)131 (67.9)Disease duration, years median (IQR)3.0 (1.0-10.0)3.0 (1.0-8.0)5.0 (0.0-13.0)Follow-up duration, months, median (IQR)24.7 (0.0-48.0)16.4 (0.0-42.7)25.2 (0.0-47.9)No of scans, n (%) 148 (31.8)21 (30.9)50 (25.9) 256 (37.1)29 (42.6)56 (29.0) 331 (20.5)12 (17.6)49 (25.4) >416 (10.6)6 (8.8)38 (19.7)Glucocorticoid use, n (%)57 (37.7)52 (76.5)149 (77.2)csDMARDs use, n (%)24 (15.9)25 (36.8)59 (30.6)b/tsDMARDs use, n (%)127 (84.1)43 (63.2)134 (69.4)Figure 1.Time course of bone density (A) and microstructure (B) in patients with PsA and RA.AcknowledgementsThe study was supported by the Deutsche Forschungsgemeinschaft (FOR2886 PANDORA, CRC1181, CRC1483 EmpkinS). Additional funding was received by BMBF (project MASCARA), the ERC Synergy grant 4D Nanoscope, and the IMI funded projects RTCure and HIPPOCRATES, and the 2022 GRAPPA Pilot Research Grant (DS).Disclosure of InterestsNone Declared.
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Köbler, Gerhard. "Vorderösterreichische Regierung und Kammer 1753-1805. Oberamt Rottenburg, bearb. v. P. Schön/E. Stemmler/P. Steuer. Vorderösterreichische Regierung und Kammer 1753-1805. Oberamt Stockach und Stadt Konstanz, bearb. v. P. Steuer/K. Krimm. Vorderösterreichische Regierung und Kammer 1753-1805. Oberämter Bregenz, Tettnang, Winnweiler und Offenburg, bearb. v. K. Krimm/ P. Schön/P. Steuer." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 126, no. 1 (August 1, 2009): 605–7. http://dx.doi.org/10.7767/zrgga.2009.126.1.605.

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Leclercq, Gabrielle, Helene Haegel, Anneliese Schneider, Estelle Marrer Berger, Antje Walz, Christophe Boetsch, Vesna Pulko, Cristiano Ferlini, and Christian Klein. "653 Dasatinib as a rapid pharmacological ON/OFF switch for T cell bispecific antibody-induced T cell activation and cytokine release." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A690. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0653.

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BackgroundT cell bispecific antibodies (TCBs) are extremely potent T cell engagers, harboring a 2+1 format with one binder to the CD3ε chain and two binders to specific tumor antigens. Crosslinking of CD3 with tumor antigens triggers T cell activation, proliferation and cytokine release, leading to tumor cell killing.1 2 TCB treatment is sometimes associated with safety liabilities due to on-target on-tumor, on-target off-tumor cytotoxic activity and cytokine release. Patients treated with TCBs may experience a Cytokine Release Syndrome (CRS), characterized by fever, hypotension and respiratory deficiency and associated with the release of pro-inflammatory cytokines such as IL-6, TNF-α, IFN-γ, and IL-1β.3 Off-tumor toxicity may occur if target antigens are expressed in healthy cells, which may potentially result in tissue damages and compromise the patient‘s safety. Rapid pharmacological blockade of T cell activation and proliferation is a promising approach to mitigate these life-threatening toxicities. Tyrosine kinases such as SRC, LCK or ZAP70 are involved in downstream signaling pathways after engagement of the T cell receptor and blocking these kinases might serve to abrogate T cell activation when required. Dasatinib was identified as a potent candidate that switches off CAR T cell functionality.4 5MethodsUsing an in vitro model of target cell killing by human peripheral blood mononuclear cells, we assessed the reversible effects of dasatinib combined with CEA-TCB or HLA-A2-WT1-TCB on T cell activation and proliferation, target cell killing and cytokine release. At assay endpoints, T cell phenotype and target cell killing were measured by flow cytometry and supernatants were analyzed by Luminex to assess cytokine release. To determine the effective dose of dasatinib, the Incucyte system was used to follow kinetics of target cells killing by TCB in the presence of a dose response of dasatinib concentrations.Results100 nM dasatinib prevented TCB-mediated target cell killing when added in the system upon restimulation of activated T cells (figure 1). Dasatinib concentrations above 50 nM fully switched off target cell killing (figure 2) which was restored upon removal of dasatinib. These data confirm that dasatinib act as a potent and reversible on/off switch for activated T cells at pharmacologically relevant doses as they are applied in patients according to the label.6ConclusionsTaken together, we provide evidence for the use of dasatinib as a pharmacological on/off switch to mitigate off-tumor toxicities or CRS by T cell engaging therapies. These data are being validated in vivo.ReferencesBacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, et al. A novel carcinoembryonic antigen T-Cell Bispecific Antibody [CEA TCB] for the treatment of solid tumors. Clin Cancer Res 2016;22(13):3286–97.Bacac M, Klein C, Umana P. CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors. Oncoimmunology 2016;5(8):e1203498.Shimabukuro-Vornhagen A, Gödel P, Subklewe M, Stemmler HJ, Schlößer HA, Schlaak M, et al. Cytokine release syndrome. J Immunother Cancer 2018;6(1):56.Weber EW, Lynn RC, Sotillo E, Lattin J, Xu P, Mackall CL. Pharmacologic control of CAR-T cell function using dasatinib. Blood Advances 2019;3(5):711–7.Mestermann K, Giavridis T, Weber J, Rydzek J, Frenz S, Nerreter T, et al. The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells. Science Translational Medicine 2019;11(499):eaau5907.Wang X, Roy A, Hochhaus A, Kantarjian HM, Chen TT, Shah NP. Differential effects of dosing regimen on the safety and efficacy of dasatinib: retrospective exposure-response analysis of a Phase III study. Clinical pharmacology : advances and applications 2013;5:85–97.Abstract 653 Figure 1Representative flow cytometry experiment reporting SKM-1 target cell viability upon first stimulation with 10 nM HLA-A2 WT-1-TCB in the absence of dasatinib (left pannel) and upon second stimulation with 10 nM HLA-A2 WT-1-TCB in the presence of 100 nM dasatinib (right pannel)Abstract 653 Figure 2Real time killing (Incucyte) of red fluorescent A375 cells loaded with RMF peptides by 10 nM HLA-A2 WT-1-TCB (left pannel) and of red fluorescent MKN45 cells by 1 nM CEA-TCB (right pannel) in the presence of different dasatinib concentrations ranging from 100 nM to 0 nM. Mean of technical duplicates + SEM
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"Scorpio maurus stemmleri." CABI Compendium CABI Compendium (January 7, 2022). http://dx.doi.org/10.1079/cabicompendium.64811.

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"Stemmler, T. ed., Liebe als Krankheit." Notes and Queries, June 1991. http://dx.doi.org/10.1093/nq/38.2.195.

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Wilson, Eric, Jonathan D. Kibble, Christine Bellew, Caridad Hernandez, Analia Castiglioni, Asra Khan, Carol Kamin, et al. "Challenges With Initial Implementation of an Intelligent Formative Assessment System." FASEB Journal 31, S1 (April 2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.576.48.

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With a grant from the National Board of Medical Examiners' Stemmler Fund, the University of Illinois at Chicago (UIC) and University of Central Florida (UCF) have introduced an intelligent formative assessment system (www.Osmosis.org) into the preclinical phase of their MD curricula. This web‐browser based and mobile application presents students with individualized regimens of study questions that aim to leverage the testing effect, spaced repetition and the mixed‐practice effect to aid long term retention. In the first semester of use, 90 of 120 UCF students tried to use the system answering an average of 136 items per individual though subsequent use of the system has continually decreased. We performed two initial focus groups with first year medical students to learn about the strengths and weaknesses of the IFAS and what factors have affected students' decisions about what study aids to adopt. Groups of 4–5 students gave informed consent and the discussions were audio taped for transcription and thematic analysis. A preliminary coding of the audio files suggests that student decisions about what study aids to use in medical school are strongly affected by advice from upperclassmen in the early part of the first year. Near‐peer advice appears to have high face validity and is readily accepted. The data also suggested that concerns for lack of time and demand for efficiency weigh most heavily on student decisions about what tools to use. The data suggest that high quality orientation is needed when introducing new technology, with widespread consultation in the learning community, including faculty and upperclassmen. New applications must be highly intuitive and easy to use for successful adoption.Support or Funding InformationNational Board of Medical Examiners' Stemmler Fund
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Wallner, Susanne, Stemmler Mark, and Jost Reinecke. "The Contributions of Propensity, Delinquent Peers, Low Parental Supervision, and Empathy to the Emergence of Antisocial Behavior in Childhood and Adolescence: Testing Developmental Path Models Combining Psychological- and Sociological-Criminological Approaches." International Journal of Developmental Science, December 22, 2020, 1–14. http://dx.doi.org/10.3233/dev-200285.

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Psychological- and sociological-criminological research refers to, for example, cumulative risk factor models (e.g., Lösel & Bender, 2003) and Situational Action Theory (SAT; e.g., Wikström, 2006). The German longitudinal study “Chances and Risks in the Life Course“ (research project A2, Collaborative Research Center 882; e.g., Reinecke, Stemmler, & Wittenberg, 2016) focuses upon the development of antisocial behavior from a psychological and sociological point of view. Two-wave panel data of two cohorts (children and adolescents) were utilized to test the power of developmental path models investigating the development of antisocial behavior. Individual risk seems to have both direct and indirect influences on antisocial behavior, supporting the ideas of risk factor models; antisocial behavior might be the outcome of the interaction between propensity and criminogenic exposure, so there is evidence for SAT. Additionally, empathy seems to be related to both propensity and low parental supervision. Implications for the study of antisocial behavior in childhood and adolescence are discussed in line with developmental criminology.
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"Theo Stemmler, ed., Natur und Lyrik. (Kolloquium der Forschungsstelle für europäische Lyrik des Mittelalters, 3.) Tübingen: Gunter Narr, 1991. Paper. Pp. 286." Speculum 68, no. 04 (October 1993): 1255. http://dx.doi.org/10.1017/s0038713400030062.

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"Stefan Horlacher and Marion Islinger, eds., Expedition nach der Wahrheit: Poems, Essays, and Papers in Honour of Theo Stemmler. Festschrift zum 60. Geburtstag von Theo Stemmler. (Anglistische Forschungen, 243.) Heidelberg: C. Winter, 1996. Pp. xxxii, 650; black-and-white frontispiece portrait, black-and-white figures, and musical examples. DM 118." Speculum 73, no. 04 (October 1998): 1194–95. http://dx.doi.org/10.1017/s0038713400108176.

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"Gerhard Stemmler, G. & Margraf-Stiksrud, J. (Hrsg.). (2015): Lehrbuch psychologische Diagnostik. Bern: Huber. 384 Seiten. ISBN 978-3-456-85518-9. 59,95 Euro." Rechtspsychologie 1, no. 3 (2015): 357. http://dx.doi.org/10.5771/2365-1083-2015-3-357.

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"Radiographic line width and surface rupture density as wear criteriaSchilling, A. Reinhold, C., Stemmler, D. and Wuttke, W. Schmierungstechnik 1989 20, (3), 86–88 (in German)." International Journal of Fatigue 12, no. 1 (January 1990): 74. http://dx.doi.org/10.1016/0142-1123(90)90383-p.

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"Theo Stemmler, ed., Liebe als Krankheit. 3. (Colloquium der Forschungsstelle für europäische Lyrik des Mittelalters. Mannheim: Forschungsstelle für europäische Lyrik des Mittelalters, Universität Mannheim, 1990. Paper. Pp. 257." Speculum 67, no. 03 (June 1992): 775. http://dx.doi.org/10.1017/s0038713400032589.

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"Theo Stemmler and Stefan Horlacher, eds., Sexualität im Gedicht. 11. Kolloquium der Forschungsstelle für europäische Lyrik. Mannheim: Forschungsstelle für europäische Lyrik, Universität Mannheim, 2000. Paper. Pp. 278. Distributed by Gunter Narr Verlag, Tübingen." Speculum 77, no. 02 (April 2002): 686. http://dx.doi.org/10.1017/s0038713400195284.

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"Theo Stemmler, ed., Schöne Frauen–Schöne Männer: Literarische Schönheitsbeschreibungen. 2. Kolloquium der Forschungsstelle für europäische Literatur des Mittelalters. (Forschungsstelle für europäische Lyrik des Mittelalters an der Universität Mannheim, 1.) Tübingen: Gunter Narr, 1988. Paper. Pp. 246; 15 color plates. DM 48." Speculum 65, no. 03 (July 1990): 801–2. http://dx.doi.org/10.1017/s0038713400110668.

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"Theo Stemmler, ed., An die Gottheit: Bittgedichte aus zwei Jahrtausenden. (Kolloquium der Forschungsstelle für europäische Lyrik, 7.) Mannheim: Forschungsstelle für europäische Lyrik an der Universität Mannheim, 1993. Paper. Pp. 194. DM 68. Available from Gunter Narr Verlag Tübingen, Dischingerweg 5, P.O. Box 2567, D-7400, Tübingen 5, Germany." Speculum 70, no. 03 (July 1995): 716. http://dx.doi.org/10.1017/s0038713400183770.

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