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Journal articles on the topic 'Stem cells – Research'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Rahat, Hashmi, and Ahmad Fahim. "Stem Cells: A Gold Mine in Dental Research and Tissue Engineering." Cancer Medicine Journal 2, no. 2 (December 31, 2019): 41–44. http://dx.doi.org/10.46619/cmj.2019.2-1012.

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The explosion of articles not only in scientific journals, but also in the print media and continuous TV debates, one could easily say the term “stem cells” has become synonym to the word “cure”. The extraordinary advances in the prevention, diagnosis, and treatment of human diseases, such as oral health issues, cancer, heart disease, diabetes and diseases of the central and peripheral nervous system, such as Parkinson's disease and Alzheimer's disease, continues to deprive people of health and well-being. Tremendous effort and exceptional research in human developmental biology has led to the identification and discovery of human stem cells.

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2

Stojkovic, Miodrag, Mark F. Pittenger, Jan A. Nolta, Majlinda Lako, T. R. J. Lappin, and Martin J. Murphy. "STEM CELLS' Position Statement on hESC Research." STEM CELLS 28, no. 9 (September 2010): 1A. http://dx.doi.org/10.1002/stem.517.

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3

Caulfield, Timothy, Kalina Kamenova, Ubaka Ogbogu, Amy Zarzeczny, Jay Baltz, Shelly Benjaminy, Paul A. Cassar, et al. "Research ethics and stem cells." EMBO reports 16, no. 1 (December 4, 2014): 2–6. http://dx.doi.org/10.15252/embr.201439819.

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4

Ikram, Huma, Darakhshan Jabeen Haleem, Zia Choudhry, and Adnan Maqsood Choudhry. "Stem cells in Parkinson's research." El Mednifico Journal 1, no. 3 (October 7, 2013): 77. http://dx.doi.org/10.18035/emj.v1i3.39.

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5

King, Anthony. "Stem cells: highlights from research." Nature 597, no. 7878 (September 29, 2021): S6—S7. http://dx.doi.org/10.1038/d41586-021-02621-4.

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6

Bolt, Hermann M. "Stem cells in toxicological research." Archives of Toxicology 91, no. 12 (November 15, 2017): 4029–30. http://dx.doi.org/10.1007/s00204-017-2120-9.

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7

Grisham, Julie. "Stem cells as research tools." Nature Biotechnology 18, no. 4 (April 2000): 366. http://dx.doi.org/10.1038/74350.

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8

Holden, C. "STEM CELLS: U.S. Public Supports Stem Cell Research." Science 310, no. 5747 (October 21, 2005): 416b. http://dx.doi.org/10.1126/science.310.5747.416b.

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9

Holden, C. "STEM CELL RESEARCH: Primate Parthenotes Yield Stem Cells." Science 295, no. 5556 (February 1, 2002): 779a—780. http://dx.doi.org/10.1126/science.295.5556.779a.

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10

Revel, Michel. "Research on Human embryonic stem cells and cloning for stem cells." Human Reproduction & Genetic Ethics 14, no. 1 (July 29, 2008): 4–14. http://dx.doi.org/10.1558/hrge.v14i1.4.

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11

Lane, Steven W., and D. Gary Gilliland. "Leukemia stem cells." Seminars in Cancer Biology 20, no. 2 (April 2010): 71–76. http://dx.doi.org/10.1016/j.semcancer.2009.12.001.

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12

Hernandez-Vargas, Hector, Nino Sincic, Maria Ouzounova, and Zdenko Herceg. "Epigenetic signatures in stem cells and cancer stem cells." Epigenomics 1, no. 2 (December 2009): 261–80. http://dx.doi.org/10.2217/epi.09.19.

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13

Shackleton, Mark. "Normal stem cells and cancer stem cells: similar and different." Seminars in Cancer Biology 20, no. 2 (April 2010): 85–92. http://dx.doi.org/10.1016/j.semcancer.2010.04.002.

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14

Alswailem, Abdulaziz M. "Stem Cells in Research: Islamic Perspectives." QScience Proceedings 2012, no. 1 (March 5, 2012): 15. http://dx.doi.org/10.5339/qproc.2012.stem.1.15.

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15

He, H., M. R. Emmett, A. G. Marshall, Y. Ji, C. A. Conrad, W. Priebe, H. Colman, et al. "Stem Cells." Neuro-Oncology 12, Supplement 4 (October 21, 2010): iv119—iv127. http://dx.doi.org/10.1093/neuonc/noq116.s18.

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16

Cheng, L., Z. Huang, W. Zhou, Q. Wu, J. Rich, S. Bao, P. Baxter, et al. "STEM CELLS." Neuro-Oncology 15, suppl 3 (November 1, 2013): iii206—iii216. http://dx.doi.org/10.1093/neuonc/not190.

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17

Hur, Min-Hee, Gabriela Dontu, and Max S. Wicha. "Cancer Stem Cells." Journal of Breast Cancer 10, no. 3 (2007): 173. http://dx.doi.org/10.4048/jbc.2007.10.3.173.

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18

Wagner, Erwin F. "Embryonic stem cells." Current Opinion in Oncology 4 (December 1992): S2—S4. http://dx.doi.org/10.1097/00001622-199212001-00002.

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19

Ghiaur, Gabriel, Jonathan M. Gerber, William Matsui, and Richard J. Jones. "Cancer stem cells." Current Opinion in Oncology 24, no. 2 (March 2012): 170–75. http://dx.doi.org/10.1097/cco.0b013e32834ec015.

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20

Goymer, Patrick. "Sensitizing stem cells." Nature Reviews Cancer 8, no. 4 (April 2008): 246–47. http://dx.doi.org/10.1038/nrc2358.

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21

Fan, Xing, and Charles G. Eberhart. "Medulloblastoma Stem Cells." Journal of Clinical Oncology 26, no. 17 (June 10, 2008): 2821–27. http://dx.doi.org/10.1200/jco.2007.15.2264.

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Medulloblastoma and other embronal brain tumors are similar in appearance and differentiation potential to neural stem and progenitor cells. Expression studies performed using human tumor samples, as well as the analysis of murine transgenic models, suggest that both multipotent cerebellar stem cells and lineage-restricted progenitors of the external germinal layer can be transformed into medulloblastoma by genetic alterations. These molecular changes frequently involve constitutive activation of signaling pathways such as Wnt, Hedgehog, and Notch, which play a key role in non-neoplastic neural stem cells. Pharmacologic blockade of the Hedgehog and Notch pathways suppresses the growth of medulloblastoma in culture and in vivo and may prove effective in targeting the small cancer stem-cell subpopulation required for tumor initiation and long-term propagation.

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22

Buss, Eike C., and Anthony D. Ho. "Leukemia stem cells." International Journal of Cancer 129, no. 10 (September 14, 2011): 2328–36. http://dx.doi.org/10.1002/ijc.26318.

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23

Finkel, E. "Research Update: Neural Cells Cultured from Stem Cells." JNCI Journal of the National Cancer Institute 94, no. 2 (January 16, 2002): 87. http://dx.doi.org/10.1093/jnci/94.2.87.

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24

Daley, George Q. "Deriving blood stem cells from pluripotent stem cells for research and therapy." Best Practice & Research Clinical Haematology 27, no. 3-4 (September 2014): 293–97. http://dx.doi.org/10.1016/j.beha.2014.10.013.

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25

Hayashi, Yohei, and Evgeniia Borisova. "Disease-Focused Research Using Stem Cells." Biomedicines 9, no. 11 (November 8, 2021): 1643. http://dx.doi.org/10.3390/biomedicines9111643.

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26

Jaworska, Dagmara, Wojciech Król, and Ewelina Szliszka. "Prostate Cancer Stem Cells: Research Advances." International Journal of Molecular Sciences 16, no. 11 (November 17, 2015): 27433–49. http://dx.doi.org/10.3390/ijms161126036.

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27

Okamoto, Oswaldo Keith, Ander Matheu, and Luca Magnani. "Stem Cells in Translational Cancer Research." Stem Cells International 2015 (2015): 1–2. http://dx.doi.org/10.1155/2015/281072.

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28

Powledge, Tabitha M. "Research on human embryonic stem cells." EMBO reports 1, no. 4 (October 2000): 297–98. http://dx.doi.org/10.1093/embo-reports/kvd084.

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29

Soria, Bernat, Francisco J. Bedoya, and Franz Martin. "Gastrointestinal Stem Cells I. Pancreatic stem cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 289, no. 2 (August 2005): G177—G180. http://dx.doi.org/10.1152/ajpgi.00116.2005.

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The transplantation of islets isolated from donor pancreas has renewed the interest in cell therapy for the treatment of diabetes. In addition, the capacity that stem cells have to differentiate into a wide variety of cell types makes their use ideal to generate β-cells for transplantation therapies. Several studies have reported the generation of insulin-secreting cells from embryonic and adult stem cells that normalized blood glucose values when transplanted into diabetic animal models. Finally, although much work remains to be done, there is sufficient evidence to warrant continued efforts on stem cell research to cure diabetes.

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30

Forsberg, E. Camilla, Deepta Bhattacharya, and Irving L. Weissman. "Hematopoietic stem cells." Stem Cell Reviews 2, no. 1 (March 2006): 23–30. http://dx.doi.org/10.1007/s12015-006-0005-z.

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31

Houghton, JeanMarie, Alexei Morozov, Iva Smirnova, and Timothy C. Wang. "Stem cells and cancer." Seminars in Cancer Biology 17, no. 3 (June 2007): 191–203. http://dx.doi.org/10.1016/j.semcancer.2006.04.003.

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32

Ross, Robert A., and Barbara A. Spengler. "Human neuroblastoma stem cells." Seminars in Cancer Biology 17, no. 3 (June 2007): 241–47. http://dx.doi.org/10.1016/j.semcancer.2006.04.006.

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33

Taurin, Sebastien, and Haifa Alkhalifa. "Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses." Neoplasia 22, no. 12 (December 2020): 663–78. http://dx.doi.org/10.1016/j.neo.2020.09.009.

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34

Trounson, Alan, Kyle Kolaja, Thomas Petersen, Klaus Weber, Maralee McVean, and Kathleen A. Funk. "Stem Cell Research." International Journal of Toxicology 34, no. 4 (April 20, 2015): 349–51. http://dx.doi.org/10.1177/1091581815581423.

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Stem cells have great potential in basic research and are being slowly integrated into toxicological research. This symposium provided an overview of the state of the field, stem cell models, described allogenic stem cell treatments and issues of immunogenicity associated with protein therapeutics, and tehn concentrated on stem cell uses in regenerative medicine focusing on lung and testing strategies on engineered tissues from a pathologist’s perspective.

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35

Ng, Ashley P. "Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms." Leukemia & Lymphoma 54, no. 5 (October 24, 2012): 922–33. http://dx.doi.org/10.3109/10428194.2012.734615.

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36

Hassan, Ghmkin, Said M. Afify, Neha Nair, Kazuki Kumon, Amira Osman, Juan Du, Hager Mansour, et al. "Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells." Cancers 12, no. 1 (December 29, 2019): 82. http://dx.doi.org/10.3390/cancers12010082.

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Cancer stem cells (CSCs) represent the subpopulation of cancer cells with the ability to differentiate into other cell phenotypes and initiated tumorigenesis. Previously, we reported generating CSCs from mouse induced pluripotent stem cells (miPSCs). Here, we investigated the ability of the CSCs to differentiate into hematopoietic cells. First, the primary cells were isolated from malignant tumors that were formed by the CSCs. Non-adherent cells (NACs) that arose from adherent cells were collected and their viability, as well as the morphology and expression of hematopoietic cell markers, were analyzed. Moreover, NACs were injected into the tail vein of busulfan conditioned Balb/c nude mice. Finally, CSCs were induced to differentiate to macrophages while using IL3 and SCF. The round nucleated NACs were found to be viable, positive for hematopoietic lineage markers and CD34, and expressed hematopoietic markers, just like homing to the bone marrow. When NACs were injected into mice, Wright–Giemsa staining showed that the number of white blood cells got higher than those in the control mice after four weeks. CSCs also showed the ability to differentiate toward macrophages. CSCs were demonstrated to have the potential to provide progenies with hematopoietic markers, morphology, and homing ability to the bone marrow, which could give new insight into the tumor microenvironment according to the plasticity of CSCs.

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37

Singh, Gyanesh. "Drosophila's contribution to stem cell research." F1000Research 4 (June 18, 2015): 157. http://dx.doi.org/10.12688/f1000research.6611.1.

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The discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. A recent development in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell biologists. In this regard, Drosophila germ cells are becoming a popular model of stem cell research. In several cases, genes that controlled Drosophila stem cells were later discovered to have functional homologs in mammalian stem cells. Like mammals, Drosophila germline stem cells (GSCs) are controlled by both intrinsic as well as external signals. Inside the Drosophila testes, germline and somatic stem cells form a cluster of cells (the hub). Hub cells depend on JAK-STAT signaling, and, in absence of this signal, they do not self-renew. In Drosophila, significant changes occur within the stem cell niche that contributes to a decline in stem cell number over time. In case of aging Drosophila, somatic niche cells show reduced DE-cadherin and unpaired (Upd) proteins. Unpaired proteins are known to directly decrease stem cell number within the niches, and, overexpression of upd within niche cells restored GSCs in older males also . Stem cells in the midgut of Drosophila are also very promising. Reduced Notch signaling was found to increase the number of midgut progenitor cells. On the other hand, activation of the Notch pathway decreased proliferation of these cells. Further research in this area should lead to the discovery of additional factors that regulate stem and progenitor cells in Drosophila.

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38

Singh, Gyanesh. "Drosophila's contribution to stem cell research." F1000Research 4 (August 2, 2016): 157. http://dx.doi.org/10.12688/f1000research.6611.2.

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The discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. Recent developments in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell biologists. In this regard, Drosophila germ cells are becoming a popular model of stem cell research. In several cases, genes that controlled Drosophila stem cells were later discovered to have functional homologs in mammalian stem cells. Like mammals, Drosophila germline stem cells (GSCs) are controlled by both intrinsic as well as external signals. Inside the Drosophila testes, germline and somatic stem cells form a cluster of cells (the hub). Hub cells depend on JAK-STAT signaling, and, in absence of this signal, they do not self-renew. In Drosophila, significant changes occur within the stem cell niche that contributes to a decline in stem cell number over time. In case of aging Drosophila, somatic niche cells show reduced DE-cadherin and unpaired (Upd) proteins. Unpaired proteins are known to directly decrease stem cell number within the niches, and, overexpression of upd within niche cells restored GSCs in older males also . Stem cells in the midgut of Drosophila are also very promising. Reduced Notch signaling was found to increase the number of midgut progenitor cells. On the other hand, activation of the Notch pathway decreased proliferation of these cells. Further research in this area should lead to the discovery of additional factors that regulate stem and progenitor cells in Drosophila.

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39

Zhang, Yiming, Binshen Chen, Peng Xu, Chunxiao Liu, and Peng Huang. "Reprogramming Prostate Cancer Cells into Induced Pluripotent Stem Cells: a Promising Model of Prostate Cancer Stem Cell Research." Cellular Reprogramming 22, no. 5 (October 1, 2020): 262–68. http://dx.doi.org/10.1089/cell.2020.0032.

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40

Yasui, Wataru, Shin-Ichi Nishikawa, and Eiichi Tahara. "Cancer stem cells." Cancer Science 98, no. 5 (May 2007): 753–56. http://dx.doi.org/10.1111/j.1349-7006.2007.00442.x.

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41

Schwarzenberger, Paul, Jay K. Kolls, and Vincent La Russa. "Hematopoietic Stem Cells." Cancer Investigation 20, no. 1 (January 2002): 124–38. http://dx.doi.org/10.1081/cnv-120000373.

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42

Reiffers, J., Ph Bernard, G. Vezon, A. Sarrat, G. Marit, B. David, and A. Broustet. "Autologous transplantation with circulating stem cells : When to collect stem cells?" Leukemia Research 10, no. 1 (January 1986): 118. http://dx.doi.org/10.1016/0145-2126(86)90205-5.

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43

SUTTER, R., G. YADIRGI, and S. MARINO. "Neural stem cells, tumour stem cells and brain tumours: Dangerous relationships?" Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1776, no. 2 (December 2007): 125–37. http://dx.doi.org/10.1016/j.bbcan.2007.07.006.

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44

Gallagher, Amy. "Research Shows Engineered NK Cells Eliminate Glioblastoma Stem Cells." Oncology Times 43, no. 14 (July 20, 2021): 17. http://dx.doi.org/10.1097/01.cot.0000767448.11048.ed.

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45

Marcon, Alessandro R., Blake Murdoch, and Timothy Caulfield. "Fake news portrayals of stem cells and stem cell research." Regenerative Medicine 12, no. 7 (October 2017): 765–75. http://dx.doi.org/10.2217/rme-2017-0060.

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46

Ware, Carol B. "Naive embryonic stem cells: the future of stem cell research?" Regenerative Medicine 9, no. 4 (July 2014): 401–3. http://dx.doi.org/10.2217/rme.14.31.

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47

Leeb, C., M. Jurga, C. McGuckin, N. Forraz, C. Thallinger, R. Moriggl, and L. Kenner. "New perspectives in stem cell research: beyond embryonic stem cells." Cell Proliferation 44 (April 2011): 9–14. http://dx.doi.org/10.1111/j.1365-2184.2010.00725.x.

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48

Seydel, C. "STEM CELL RESEARCH: Stem Cells May Shore Up Transplanted Hearts." Science 295, no. 5553 (January 11, 2002): 253b—254. http://dx.doi.org/10.1126/science.295.5553.253b.

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49

Vogel, G. "STEM CELL RESEARCH: Rat Brains Respond to Embryonic Stem Cells." Science 295, no. 5553 (January 11, 2002): 254b—255. http://dx.doi.org/10.1126/science.295.5553.254b.

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50

Hill, R. P., and R. Perris. ""Destemming" Cancer Stem Cells." JNCI Journal of the National Cancer Institute 99, no. 19 (September 25, 2007): 1435–40. http://dx.doi.org/10.1093/jnci/djm136.

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