Journal articles on the topic 'Steinbeck Research Center'

This article examines the intertidal ecological research of the commercial lab owner and popular science writer Edward F. Ricketts, best known as the prototype for John Steinbeck’s character “Doc” in the novel Cannery Row (1945). Ricketts’s friendship with Steinbeck and unconventional philosophical style have regrettably overshadowed his scientific work, particularly his novel faunal zonation surveys of the North American Pacific littoral in the 1930s and 1940s. These surveys resulted in a landmark handbook, Between Pacific Tides (1939), designed for novices and specialists alike. Ricketts’s work demonstrates how the place of ecological investigation (Billick and Price)—here Monterey Bay’s pounding surf, storm-tossed debris, eclectic bohemianism, and the collaborative energies at Hopkins Marine Station—“imprinted” West Coast animal ecology. At first, Ricketts adopted the physiological methods and conceptions of ecological holism he had learned at the University of Chicago under mentor Warder C. Allee in the early 1920s. Allee had conducted his investigations of intertidal organisms in the relatively placid bays and estuaries at the Woods Hole research center on Cape Cod, Massachusetts. Allee envisioned animal aggregations as higher-order societies guided by “unconscious cooperation” and evolving toward a climax state. Yet Ricketts found that physiochemical factors, such as temperature and salinity, could not explain the distribution of organisms amid the Pacific’s far more precarious rough-and-tumble surf, nor could they account for fierce competition among organisms. Rejecting Allee’s cooperative metaphors, Ricketts came to see community structure as an unintended result of tidepool invertebrates’ Darwinian struggle to occupy resource niches—a “set of sieves” that transferred nourishment from one part of the aggregation to the next, binding it together in interlocking food webs. Through dialogue with Steinbeck about the implications of modern physics during their Sea of Cortez voyage (1940), Ricketts developed a “unified field hypothesis” to conceptualize the dynamic interwovenness created by transfers of metabolic energy. Yet Steinbeck ultimately held fast to a super-organismic understanding of ecological holism—a hierarchical relationship between constituents and the whole that underlays the novelist’s idea of the human “phalanx” in Grapes of Wrath and other works. The article offers new insights about the ecological origins of Steinbeck and Ricketts’s disputes over “non-teleological” reasoning and the pair’s divergent understandings of nature, society, and progressive politics.

Im Rahmen eines vom BMBF (Bundesministerium für Bildung und Forschung) geförderten Projektes erforschte die Firma Optik-Elektro Huber GmbH in Zusammenarbeit mit dem Steinbeis-Transferzentrum für Produktion und Organisation ein neuartiges Reinigungsverfahren von komplexen, oberflächenempfindlichen Bauteilen. Im Fokus des Beitrags steht der Aufbau und die Wirkungsweise des Systems, welches auf der Einzelteilhandhabung der einzelnen Werkstücke in direkter Kopplung mit dem Fertigungsprozess beruht.   As part of a project, funded by the Federal Ministry of Education and Research (BMBF), the company Optik-Elektro Huber GmbH, in cooperation with the Steinbeis-Transfer Center for Production and Organization, developed a novel cleaning process for complex, surface-sensitive components. The article is focused on the structure and mode of operation by the system which is based on the handling of individual components directly interacting with the manufacturing process.

Adaptation to modern requirements of buildings, which have got a status of architectural landmarks, is always a compromise between the preservation of authentic elements and bringing the building into line with current standards. In the Building of the Institute of Radio Electronics, the architectural landmark of Kharkiv region, it was necessary to build an elevator to provide barrier-free access to the premises.The goal of this research is to find the best place for a new elevator, where meddling into the building’s body from one side will make minimum damage for its structure and interior design and from another side can be most convenient for users.To solve this problem, it was necessary to collect materials about “Institute of radio electronics” building: conduct bibliographic surveys and search materials in different archives. Historical documents, photos, sketches and historical drawings and field research materials about this building must be put together. Analysis of the collected materials showedthat building was designed in the second part of 1930 for new Kharkov Civil Engineering Institute (KhCEI), which was found in April 1930. In 1930 the place for the building structure was chosen. A KhCEI building architectural competition took place in 1930. The authors of the winning project were Yakiv Steinberg, Rosaliya Fridman. For the KhCEI building J. Steinberg suggested to make experimental constructivist complex. The architect paid special attention to the functioning of the building. Taking into attention that the formation of the department structure of the institute continued until 1932, the architects had only approximate characteristics of the functioning of the house.The building had a long distributor block to which other blocks, intended for separate specializations, were adjoined at right angles. The stairways or ramps were in the corridors of the distributor block as well as in the opposite edges of the transverse blocks. The ground floors and second floors had corridors, which distributedstudents to the necessary premises. The first floor and partly the ground floor were intended for laboratories. The second floor, which had a corridor system, was divided into small rooms for group classes, and the third floor contained large halls for drawing classes had free planning (later became enfilades). Near the stairs there were also the servicing premises combined in one block –toilets, tool rooms and archives, professors' offices with small subdepartment libraries.Only one half of this project was finished in 1933. The complex was damaged during the II World war. In August 1943, the destroyed building was handed to Kharkiv Mining Engineering Institute (KhMEI).In 1944-1945 Dmitry Torubarov developed the project of reconstruction of this complex. His solution preserved Steinberg's idea, but added new parts to it. Torubarov changed the outer view of the complex, because the environment around it had been modified.In 1930 Steinberg worked with an empty area, where were only the main road and the ravine. He made a composition, which was supposed to look from the view point between the main road and the ravine best of all. In 1946 Torubarov worked in the new town area, where the ravine created an empty space in front of the composition. The corner between the main road (that became a significant avenue later) and the ravine wasn't so important. Torubarov moved the center of the composition to the center of facade facing to the ravine.

Abstract Background: Priapism is a serious complication associated with Sickle Cell Disease (SCD) that may be a manifestation of underlying vasculopathy. The Centers for the Study of Complex Diseases of Childhood (CSCCD), comprising independent Comprehensive Sickle Cell Centers, demonstrated an association of priapism with hemolysis.1 Previously, we identified two groups of people with SCD based on red blood cell (RBC) adhesion under hypoxic conditions: those patients whose RBCs showed hypoxia-enhanced adhesion (HEA) and those whose did not (non-HEA).2 Patients with HEA had evidence for more hemolysis in vivo. Here, we aimed to examine (1) the association of HEA with hypoxia in vivo, and (2) RBC adhesion in normoxic and hypoxic conditions in male patients with or without a history of priapism. Methods: This retrospective study was conducted at the Adult Sickle Cell Disease Clinic at the University Hospitals Seidman Cancer Center, in Cleveland, OH between 2015 to 2018. Blood samples were obtained from 26 male subjects (29 samples, 25 HbSS and 1 HbSS HPFH). Adhesion experiments were performed as previously reported by passing surplus whole blood through LN-immobilized microchannels at physiological conditions under both normoxic and hypoxic conditions.2,3 Adherent RBCs were then quantified with microscope after a wash step. The median value was used for data analyses from multiple samples obtained from an individual. Chart review was conducted to examine results of hypoxia testing obtained in vivo as part of routine clinical care. Results: Male subjects with HbSS and a history of priapism had higher HEA in comparison to subjects without a history of priapism (3268 ± 5647 vs. 122 ± 1218, p=0.016). However, there was no significant difference between RBC adhesion of the two groups under normoxic conditions (529 ± 1528 vs. 402 ± 280). More male subjects with priapism had hypoxia in vivo (10 out of 14) than subjects without priapism (5 out of 12). Compared to male subjects with a history of priapism, those without a history of priapism had lower lactate dehydrogenase levels (474 ± 267 vs. 290 ± 215, p=0.008). Conclusions: Our data showed that subjects with a history of priapism had a higher HEA and tended to have more evidence for hypoxia in vivo than did subjects without a history of priapism. Further, male subjects with hypoxia in vivo had more HEA than did those without hypoxia in vivo (not shown). Hypoxia in vivo may cause increased RBC damage (reflected by HEA), hemolysis, nitric oxide depletion, and consequent vasculopathy, resulting in priapism. Hypoxia may be treatable, when identified in subjects with a history priapism in vivo or possibly with HEA in vitro. This could plausibly modify disease severity in some cases. References: Nolan VG, Wyszynski DF, Farrer LA, Steinberg MH. Blood. 20015 Nov;106(9):3264-7. doi: 10.1182/blood-2005-04-1594 Kim M, Alapan Y, Adhikari A, Little JA, Gurkan Microcirculation. 2017 Jul;24(5). doi: 10.1111/micc.12374. Alapan Y, Kim C, Adhikari A, Gray KE, Gurkan-Cavusoglu E, Little JA, Gurkan Transl Res. 2016 Jul;173:74-91.e8. doi: 10.1016/j.trsl.2016.03.008. Epub 2016 Mar 19. Disclosures Little: NHLBI: Research Funding; PCORI: Research Funding; Hemex: Patents & Royalties: Patent, no honoraria; Doris Duke Charitable Foundations: Research Funding.

Abstract Background: Adenosquamous carcinoma of the pancreas (ASCP) is a very rare and highly aggressive variant of pancreatic ductal adenocarcinoma (PDA), accounting for 0.5-4% of all pancreatic cancer cases in the US. Current data indicates that epigenetic changes and Myc overexpression lead to squamous transdifferentiation of pancreatic tumor cells and development of ASCP. Minnelide is an oral anti-super-enhancer drug that inhibits Myc expression in preclinical models of ASCP. Oral Minnelide has been previously tested in the clinic where a Phase I study determined a recommended phase 2 dose of 2 mg/day. Major toxicities included neutropenia and sepsis. We hypothesize that Minnelide will be safe and effective in patients with advanced ASCP. Methods: This Phase II open label, single arm study being conducted at the NIH Clinical Center in Bethesda, MD (NCT04896073) will enroll up to 25 evaluable participants with advanced ASCP that has been previously treated. Eligibility criteria include: histologically confirmed ASCP (≥30% malignant squamous component), presence of metastatic, recurrent, or locally advanced unresectable disease, and progression or intolerance ≥1 prior systemic treatment for advanced disease. All participants will self-administer Minnelide at 2mg PO daily on days 1-21 of each 28-day cycle, for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Restaging scans will be performed every 8 weeks. Optional biopsies will be requested at baseline, mid-cycle 1 and at time of progression. The primary objective is to determine the antitumor activity of Minnelide by evaluating the disease control rate. Secondary objectives are determination of drug safety in this patient population, progression free survival, and overall survival. Exploratory objectives include assessment of Minnelide effect on tumor cell epigenetics, Myc expression and immune cell populations using on-treatment tumor biopsy tissues. Changes in circulating tumor DNA and circulating immune cell populations upon treatment will also be evaluated. A Simon optimal two-stage phase II trial design will be used. If 3 of the first 12 patients experience disease control, then enrollment will continue up to 25 evaluable participants. If ≥8 of 25 participants experience disease control this would rule out an unacceptably low clinical benefit of 20% in favor of 40% (α = 0.1, β = 0.2). This trial opened for accrual in July 2021. Citation Format: Nebojsa Skorupan, Mehwish I. Ahmad, Seth M. Steinberg, Jane B. Trepel, Derek Cridebring, Haiyong Han, Daniel D. Von Hoff, Christine Alewine. A phase II trial of the super-enhancer inhibitor Minnelide in advanced refractory adenosquamous carcinoma of the pancreas (ASCP) [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-054.

Abstract Background: Patients with relapsed small cell lung cancer (SCLC) have a poor prognosis and few therapeutic options, especially after standard treatment of platinum doublet chemotherapy +/- immunotherapy. SCLC is characterized with high replication stress. A previous single-arm phase 2 study showed anti-tumor activity with the addition of ataxia-telangiectasia–mutated and rad3-related (ATR) kinase inhibitor berzosertib to topotecan. This study aimed to investigate whether the addition of berzosertib to topotecan improves clinical outcomes in patients with relapsed SCLC. Patients and methods: The randomized, open-labeled phase 2 study recruited patients with SCLC and relapse after one or more prior therapies from 16 US cancer centers as members of the National Cancer Institute Cancer Therapy Evaluation Program. Patients previously treated with topotecan were not eligible. Eligible patients were randomly assigned to receive topotecan (arm 1: 1.25 mg/m2 intravenously on days 1 through 5) alone or with berzosertib (arm 2: 210 mg/m2 intravenously on days 2 and 5), in 21-day cycles. Randomization was stratified by sensitivity to first-line platinum-based chemotherapy. The primary endpoint was progression-free survival (PFS) in the intention-to-treat population. Secondary endpoints included overall survival (OS), objective response rate (ORR), and duration of response (DOR) in the overall population and in platinum-sensitive or -resistant patients. Results: Between December 2019 and December 2022, sixty patients were randomly assigned to receive topotecan alone (n=20) or in combination of with berzosertib (n=40). After a median potential follow-up of 21.3 months, there was no difference in PFS between the two arms [median: 3.0 months in arm 1 versus 3.9 months in arm 2, hazard ratio (HR) (95% CI): 0.80 (0.46 to 1.41), P = 0.44]. OS was significantly longer with the combination [5.4 months in arm 1 versus 8.9 months in arm 2, HR (95% CI): 0.53 (0.29 to 0.96), P = 0.033]. Of 57 evaluable patients, a numerically higher ORR was observed in patients receiving the combination: 5.6% (1/18, 95% CI: 0.1% to 27.3%) in arm 1 versus 25.6% (10/39, 13.0% to 42.1%) in arm 2. In an unplanned post hoc analysis, the depth of target lesion responses was significantly associated with better OS in patients on the combination arm (adjusted P = 0.022 by landmark analysis), suggesting that the deeper tumor regressions by the combination of berzosertib and topotecan may have eventually contributed to OS improvement. Adverse event profiles were similar between the two arms. Conclusions: In this randomized clinical trial, berzosertib plus topotecan did not improve PFS compared with topotecan alone in patients with relapsed SCLC. However, the combination significantly improved OS, suggesting potential efficacy of replication-stress targeted therapies in SCLC. Citation Format: Nobuyuki Takahashi, Zhonglin Hao, Liza C Villaruz, Jun Zhang, Jimmy Ruiz, W. Jeffrey Petty, Hirva Mamdani, Jonathan W Riess, Jorge Nieva, Jose M Pachecho, Alexander D Fuld, Elaine Shum, Aman Chauhan, Samantha Nichols, Hirity Shimellis, Jessie McGlone, Linda Sciuto, Danielle Pinkiert, Chante Graham, Meenakshi Shelat, Robbie Kattappuram, Melissa Abel, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Ajit Kumar Sharma, Rajesh Kumar, Justin Malin, Christopher W Schultz, Shubhank Goyal, Christophe E Redon, Yves Pommier, Mirit I Aladjem, Steven D Gore, Seth M Steinberg, Rasa Vilimas, Parth Desai, Anish Thomas. Efficacy of ATR inhibitor berzosertib plus topotecan or topotecan alone in patients with relapsed small cell lung cancer: A randomized clinical trial [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr LB_A10.

Abstract Background. Avascular necrosis (AVN) is a serious complication of sickle cell disease (SCD) that can lead to significant morbidity including chronic pain and physical impairment with treatment depending on the patient's pain severity and functional limitation. Patient age, hemoglobin levels, and abnormal rheology, particularly high blood viscosity, or thickness, and percentage of dense red blood cells, defined as cells >1.11 mg/mL have been identified as risk factors for the development of AVN, but their contributions to the subsequent clinical course has not been described. The natural history of AVN has been described as chronic and progressive without significant surgical or physical therapy based intervention. However, this description was established before widespread MRI use in diagnosis, or hydroxyurea (HU). A new evaluation of the natural history of AVN is needed. Objective: Review the natural history of AVN at our institution in patients for whom repeat imaging is available, and determine if patient demographics, treatment type, and laboratory data, including rheological values, predict of clinical course. Methods. We identified all patients with a diagnosis of AVN with diagnostic and follow-up imaging studies (pelvic X-rays or MRI of the hip), receiving care at Texas Children's Hospital Hematology Center 2006 to 2018, and collected demographic, treatment, rheological and clinical laboratory data. Patient radiographic images at diagnosis and follow up were reviewed and scored by a board certified pediatric radiologist using the Steinberg criteria. Laboratory values for each patient were collected as available from time of diagnosis through to the date of follow up imaging. Longitudinal patient blood samples were collected for rheological measurements under an IRB approved protocol. Whole blood viscosity was measured on a cone and plate viscometer (DV3T Rheometer, AMETEK Brookfield, Middleboro, MA, USA) at 45 and 225 s-1 at 37oC within 4 hours of sample collection in an EDTA vacutainer tube. Percent dense red blood cells (%DRBCs) were measured by an ADVIA 120 Hematology System (Siemens Medical Solutions USA, Inc., Malvern, PA, USA). Statistical analysis comparing groups with and without radiographic improvement was performed using a two-tailed Student's t-test. Results. 16 patients had repeat imaging, allowing for assessment of radiographic improvement (Table1). All were diagnosed via X ray or MRI of the pelvis. Five of 16 patients had resolution or significant radiographic improvement of AVN without orthopedic intervention or prolonged physical therapy, while 11 patients had stable or worsening disease. In the group with radiographic improvement, the mean age was 9.9 years (SD=2.5) and 14.6 years (SD=2.2) in the group without radiographic improvement (p= 0.002). Five patients underwent core decompression with bone marrow aspirate concentrate injection; one progressed to complete femoral head collapse while the rest had stable or worsening disease. Mean hemoglobin (Hb), fetal hemoglobin (HbF), percent DRBCs, whole blood viscosity, and extent of AVN at diagnosis by Steinberg criteria were not statistically different between the patients that showed improvement and those that did not. Conclusions. Our results challenge the paradigm of untreated AVN in SCD as an inexorably progressive disease. Here we present 5 cases of significant radiographic improvement of AVN without surgical or significant physical therapy interventions. Conversely, 5 AVN cases treated with core decompression remained stable or worsened. Given our small cohort, we were unable to establish laboratory or rheological predictors of spontaneous resolution. However, patients in the radiographic improvement group were younger than patients with progressive disease. HU has shown promise in improving vascular complications in SCD patients however more research is needed to delineate its role as a modifier of AVN natural history as it was not correlated with the improved group in our study (all our study patients were on HU either prior to diagnosis or started during the follow up period). Given the findings that significant radiographic improvement is possible with minimal or no intervention, providers should closely weigh the risks and benefits of observation versus surgical intervention, particularly in young patients with SCD. Disclosures No relevant conflicts of interest to declare.

Background: Vaso-occlusive crisis (VOC) is the hallmark complication of sickle cell disease (SCD) (1), and usually requires intravenous (IV) opioid treatment in emergency room (ER) or acute care center (ACC), a designated observation unit to manage uncomplicated VOC (2). Starting October 2017, there was a critical nationwide drug shortage in parental hydromorphone, a commonly used medication to treat VOC. In April 2018 the University of Illinois Health System (UI Health) adopted a standardized pain management protocol that limited opioids in the ER or ACC to two doses of IV or IM morphine and/or oral opioid. This study evaluates the impact of this standardized pain management protocol on managing VOC in SCD. Methods: A total of 373 SCD adults treated at UI Health from May 2017 to Oct 2018 had at least one ER or ACC visit or hospitalization for VOC. Data on VOC-related patient visits to the ACC, ER, and admissions to the inpatient floors were collected from the electronic medical record and evaluated based on three time periods (prior to shortage: May 2017-Oct 2017; transition: Oct 2017-Apr 2018; and post protocol: Apr 2018-Oct 2018). Descriptive statistics, the Cochrane trend test and Jonckheere-Terpstra trend test were used for data analysis. The study was approved by the Institutional Review Board prior to the initiation of chart review. Results: Between May 2017 and Oct 2018, the 373 SCD adult patients had a total of 1,915 ACC, 2,635 ER and 1,832 inpatient visits. After implementation in April 2018, the compliance rate with the standardized pain protocol was 99.7% in the ACC and 85.1% in the ER. In the ACC, the number of visits decreased after standardized pain protocol implementation, whereas the number of visits increased in the ER (Figure 1). The admission rate to the inpatient service from the ACC increased significantly while the admission rate from the ER remained relatively stable (Table 1). The numbers of opioid doses and the total opioid dose to treat VOC decreased in the ACC, but not in ER. Utilization of oral opioids increased in both settings (Table 1). The number of inpatient hospitalizations increased with implementation of the standardized protocol (542 vs. 626 vs. 664), and the 30-day readmission rate increased (49% vs. 51% vs. 57%, p = 0.003), but the length of hospital stay was reduced (p < 0.001). Summary: Implementation of a standardized pain treatment protocol due to the parenteral hydromorphone shortage decreased the utilization of the ACC compared to the ER and the inpatient service, and resulted in reduced opioid dose but increased admission rates from the ACC. The 30-day readmission rate to inpatient service increased but the length of stay was reduced. A standardized pain protocol that limits opioids to two doses in the acute setting may not be an optimal approach. Reference: F. B. Piel, M. H. Steinberg, D. C. Rees, Sickle Cell Disease. N Engl J Med376, 1561-1573 (2017).J. Han et al., Program expansion of a day hospital dedicated to manage sickle cell pain. Am J Hematol93, E20-E21 (2018). Disclosures Saraf: Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees; Pfizer: Research Funding. Gordeuk:CSL Behring: Consultancy, Honoraria, Research Funding; Global Blood Therapeutics: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Honoraria, Research Funding; Modus Therapeutics: Consultancy, Honoraria; Imara: Research Funding; Ironwood: Research Funding; Inctye: Research Funding; Pfizer: Research Funding; Emmaus: Consultancy, Honoraria.

Hydroxyurea (HU) is approved in the EU and USA for prevention of vaso-occlusive crises (VOC) including acute chest syndromes (ACS) in patients over 2 years with sickle-cell disease (SCD). The major benefits of HU in SCD are directly related to its abilities to increase HbF, decrease sickling of red blood cells and hemolysis, leading to reduction of vaso-occlusive episodes, need for blood transfusions and consequently reduction of morbidity and mortality. Adherence to the treatment is paramount for effectiveness, but in spite of proven benefits, barriers to adherence persist.[1] ESCORT-HU study (European Sickle Cell Disease COhoRT - HydroxyUrea), is a multicentric, prospective, non-interventional European study designed to evaluate the safety profile of HU in real life. Patients were enrolled from January 2009 to June 2017 with a follow-up of up to 10 years. All interruptions and resumptions of HU treatment exceeding 15 days were recorded in this study. We hereby present the analysis of the group of patients who self-discontinued HU at least once during the study before informing their caregiver, with a view to identify potential barriers to long-term adherence. In total, 1906 patients were enrolled in ESCORT-HU from 63 centers in France, Germany, Greece and Italy. Of these, 619 patients (32%) stopped HU for over 15 days at least once, and around a third (11% of all patients) were due to patient's will. The mean duration of HU treatment before the first discontinuation was 4.8 ± 5.1 years. Data are summarized in table 1. Compared to the rest of the cohort, the 'treatment discontinuation' group had similar distribution by gender and indication for HU prescription, but a higher proportion of adults stopped HU more than 15 days. It is notable that the proportion of patients with SC genotype was higher in the 'treatment discontinuation' group (4.5% vs 1.7%). The patients in the 'treatment discontinuation' group had more frequent SCD symptoms before enrolment in the study (table 2). Hematological and clinical improvement compared to the baseline was observed in both groups. However, average mean Corpuscular Volume (MCV) and Fetal Hemoglobin percentage (HbF%) were lower and mean percentages of patients with SCD symptoms were higher over the three years of follow-up in the 'treatment discontinuation' group, suggesting that HU daily dose was insufficient (table 2). Sixty patients have no treatment resumption date reported which suggest a permanent interruption of their treatment. Among them 32% preferred to switch to another HU medicinal product and 13% have safety issue (table 3). Understanding and managing self-discontinuation of HU before taking medical advice is challenging for the physician. It is tempting to speculate that it may be due, at least in part, to lack of effectiveness potentially due to an underdosage of the treatment. Resistance to the treatment may also be suggested based on past literature data revealing a great variability in the response (determined by HbF%) to HU therapy. There is evidence that genetic modifiers affect individual response to HU.[2],[3] Finally, weariness from long-term use may also explain the patient's wish to discontinue HU. But treatment at optimal effective should be the primary goal of caregivers. [1]Smaldone A., Manwani D., Green NS, Greater number of perceived barriers to hydroxyurea associated with poorer health-related quality of life in youth with sickle cell disease, Pediatr Blood Cancer. 2019 [2] Steinberg MH, Voskaridou E, Kutlar A, Loukopoulos D, Koshy M, et al. (2003). Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease. Am J Hematol 72: 121-126 [3] Ware RE, Despotovic JM, Mortier NA, Flanagan JM, He J, et al. (2011) Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia. Blood 118: 4985-4991 Disclosures Galactéros: Addmedica: Membership on an entity's Board of Directors or advisory committees. Voskaridou:Celgene Corporation: Consultancy, Research Funding; Protagonist: Research Funding; Genesis: Consultancy, Research Funding; Acceleron: Consultancy, Research Funding; Addmedica: Membership on an entity's Board of Directors or advisory committees. Cannas:Addmedica: Membership on an entity's Board of Directors or advisory committees.

Abstract Hydroxyurea (HU) is approved in EU and USA for preventing vaso-occlusive crises (VOC) including acute chest syndromes (ACS) in adults, adolescents and children ≥2 years with sickle-cell disease (SCD). Further to the double blinded, randomized controlled Multicenter Study of Hydroxyurea administration (MSH) which provided the first data on clinical efficacy of HU (Charache 1995), a few follow-up studies suggested that long-term use of HU resulted in significant clinical benefit on patient outcome. This was reflected by lower mortality rates in HU-treated patients compared to conventionally treated patients (Steinberg 2003 & 2010, Voskaridou 2010, Lê 2015). Sustained hematological and clinical response after several years of follow-up at maximal tolerated dose was further shown in subsequent studies, especially the LaSHS study (Voskaridou 2010). Based on these data, the ESCORT-HU (European Sickle Cell Disease COhoRT - HydroxyUrea) study was launched aiming in the establishment of the safety and the sustainability of hematological and clinical benefits to HU administration in the prevention of sickle-cell vaso-occlusive crises in routine practice. We hereby present preliminary results from a large cohort of patients enrolled in the study between January 2009 and June 2017. 1920 patients were enrolled from 63 centers in France, Germany, Greece and Italy, For 147 of the 600 HU-naive patients (never treated with HU before enrolment) and started on HU for VOC or ACS, there was documented clinical outcome (number of VOC >48h and ACS episodes per year) over a 4-year follow-up period. These patients were selected for analysis to evaluate sustainability of clinical and hematological HU response in routine practice. Demographic data and Hb genotypes are displayed in table 1. The children group was mainly composed of βS/βS patients, while adults were mainly βS/βS and βS/β-thal patients. As shown in figure 1 and 2, there was a dramatic reduction in the number of VOC >48h and ACS episodes (-79%) from year 1 in adults and children, with results comparable to previous randomised clinical trials in adults (Charache et al., 1995) and children (Jain et al, 2012). Overall, the reduction in number of VOC (>48h) and ACS was stable over the 4 years of follow-up. This reduction is inversely proportional to the increase in HbF. There were however a moderate rebound in children from year 2 while adults remained stable. Similarly, there was reduction in the proportion of adults and children requiring transfusion (figure 3). The clinical benefit of HU was higher in severe forms of SCD, as displayed by the markedly reduced number of patients with ≥ 3 VOC episodes (>48h)/year at year 1 (figure 4). Hematological response to HU was evidenced as soon as year 1 with a marked increase in HbF% (+6-10) and were maintained over subsequent years of treatment (figure 1 and 2) as the dose of HU was further increased. While there was no striking differences in HbF% variation between age groups and genotypes, the requirement for increase in HU dose over the 4 years of follow-up was markedly higher in children, probably reflecting the different severity between the two population at entry (figure 5). The red cell red cell mean corpuscular volume (MCV) could be used as a measurement of compliance, showing differences between age group (figure 5). There was, as expected, an apparent negative correlation between induction of HbF synthesis and number of VOC >48h and ACS episodes at year 1, attesting to reduced effectiveness of treatment in some patients (figure 6). Improvement in blood parameters was accompanied by mild reduction of absolute neutrophil and platelet count although not to the point of myelosuppression (defined as ANC < 2 x 109/L), showing that MTD was not targeted in routine practice. Treatment-emergent adverse reactions occurring in the 147 patients of the cohort over the 4 years of follow-up were consistent with the known safety profile of hydroxyurea. The commonest effects included neutropenia and thrombocytopenia (25 events in 13 patients) and were easily manageable with temporary discontinuation of treatment. No tumorigenesis was reported. In conclusion, preliminary results from ESCORT-HU in 147 patients treated with HU showed sustained hematological and clinical response while MTD was not targeted, with differences between adults and children which may be attributed in part to reduced compliance in the latter group. Disclosures Voskaridou: Celgene Corp: Membership on an entity's Board of Directors or advisory committees, Research Funding; Acceleron: Membership on an entity's Board of Directors or advisory committees, Research Funding. Oevermann:Addmedica: Membership on an entity's Board of Directors or advisory committees. Thuret:Addmedica: Research Funding; bluebird bio: Research Funding; Novartis: Research Funding. Steschenko:Novartis: Membership on an entity's Board of Directors or advisory committees.

The knowledge of the science of human body parts for early childhood is very important so that children have the ability to recognize and support the cleanliness and health of members of the body, as well as so that they recognize their identity. In addition, introducing environmentally friendly material for early childhood teachers to enrich learning media. This study aims to improve student learning outcomes in science using environmentally friendly media. The topic raised in this search was about recognizing body parts and their benefits and treatments. This type of research is action research. Respondents involved 19 early childhood students. The results showed that there was an increase in subjects' understanding of swallowing extremities and treatment 60% in the pre-cycle phase, 80% in the first cycle and 93% in the second cycle. The findings show that the use of happy body media has a positive effect on limb recognition. Further research is recommended on environmentally friendly media and ways of introducing limbs to early childhood through media or strategies suitable for the millennial era. Keywords: Media (Happy Body), Early Childhood Science, Human Body Parts References: Anagnou, E., & Fragoulis, I. (2014). The contribution of mentoring and action research to teachers’ professional development in the context of informal learning. Review of European Studies, 6(1), 133–142. Belsky, J., Steinberg, L., & Draper, P. (1991). Childhood experience, interpersonal development, and reproductive strategy: An evolutionary theory of socialization. Child Development, 62(4), 647. Black, M. M., & Hurley, K. M. (2016). Early child development programmes: further evidence for action. The Lancet Global Health, 4(8), e505–e506. Blok, H., Fukkink, R., Gebhardt, E., & Leseman, P. (2005). The relevance of delivery mode and other programme characteristics for the effectiveness of early childhood intervention. 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Early Schooling of Children at Risk. 31. Reynolds, A. J. (1992). Comparing measures of parental involvement and their effects on academic achievement. Early Childhood Research Quarterly, 7(3), 441–462. https://doi.org/10.1016/0885-2006(92)90031-S Reynolds, A. J., Ou, S.-R., & Topitzes, J. W. (2004). Paths of Effects of Early Childhood Intervention on Educational Attainment and Delinquency: A Confirmatory Analysis of the Chicago Child-Parent Centers. Child Development,75(5), 1299–1328. https://doi.org/10.1111/j.1467-8624.2004.00742.x Reynolds, A. J., Temple, J. A., Ou, S.-R., Arteaga, I. A., & White, B. A. B. (2011). School-Based Early Childhood Education and Age-28 Well-Being: Effects by Timing, Dosage, and Subgroups. 333, 6. Shute, V. J., Hansen, E. G., Underwood, J. S., & Razzouk, R. (2011). A Review of the Relationship between Parental Involvement and Secondary School Students’ Academic Achievement. Education Research International, 2011, 1–10. https://doi.org/10.1155/2011/915326 Simons-Morton, B. G., & Crump, A. D. (2003). Association of Parental Involvement and Social Competence with School Adjustment and Engagement Among Sixth Graders. 6. Steinberg, L., Lamborn, S. D., Dornbusch, S. M., & Darling, N. (1992). Impact of Parenting Practices on Adolescent Achievement: Authoritative Parenting, School Involvement, and Encouragement to Succeed. Child Development, 63(5), 1266. https://doi.org/10.2307/1131532 Sun, S., Hullman, G., & Wang, Y. (2011). Communicating in the multichannel age: Interpersonal communication motivation, interaction involvement and channel affinity. 9. Sy, S., & Schulenberg, J. (2005). Parent beliefs and children’s achievement trajectories during the transition to school in Asian American and European American families. International Journal of Behavioral Development, 29(6), 505–515. https://doi.org/10.1080/01650250500147329 Thapa, A., Cohen, J., Guffey, S., & Higgins-D’Alessandro, A. (2013). A Review of School Climate Research. 29. Turney, K., & Kao, G. (2009). Barriers to School Involvement: Are Immigrant Parents Disadvantaged? The Journal of Educational Research, 102(4), 257–271. https://doi.org/10.3200/JOER.102.4.257-271 Wong, S. W., & Hughes, J. N. (2006). Ethnicity and Language Contributions to Dimensions of Parent Involvement. School Psychology Review, 35(4), 645–662. https://doi.org/10.1080/02796015.2006.12087968

Sharenting is a habit of using social media to share content that disseminates pictures, videos, information, and parenting styles for their children. The purpose of this article is to describe the sharenting phenomenon that occurs among young parents, and the importance of parenting programs, rather than protecting children's privacy. Writing articles use a qualitative approach as a literature review method that utilizes various scientific articles describing the sharenting phenomenon in various countries. The findings show that sharenting behaviour can create the spread of children's identity openly on social media and tends not to protect children's privacy and even seems to exploit children. Apart from that, sharenting can also create pressure on the children themselves and can even have an impact on online crime. This article is expected to provide benefits to parents regarding the importance of maintaining attitudes and behaviour when sharing and maintaining children's privacy and rights on social media. Keywords: Sharenting on social media, Children's Privacy, Parenting Program References: Åberg, E., & Huvila, J. (2019). Hip children, good mothers – children’s clothing as capital investment? Young Consumers, 20(3), 153–166. https://doi.org/10.1108/YC-06-2018-00816 Altafim, E. R. P., & Linhares, M. B. M. (2016). Universal violence and child maltreatment prevention programs for parents: A systematic review. Psychosocial Intervention, 25(1), 27–38. https://doi.org/10.1016/j.psi.2015.10.003 Archer, C., & Kao, K.-T. (2018). Mother, baby, and Facebook makes three: Does social media provide social support for new mothers? Media International Australia, 168(1), 122–139. https://doi.org/10.1177/1329878X18783016 Bartholomew, M. K., Schoppe-Sullivan, S. J., Glassman, M., Kamp Dush, C. 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Summary For a long time already, attempts have been made to bridge the gap between research and practice. In this respect, society demands that universities should have a bigger social impact. University and society/societal organizations should work together (co-create) during the entire research process, from the articulation of the research question until the implementation of the results. There is controversy about the question whether it is possible for universities to work together with practice and at the same time to retain the academic quality standards. First, this article deals with the question what characteristics are important for universities in order to be able to work together with practice. In this respect, the Dutch scientist Steinbuch came up with a tantalizing idea arguing that universities may take a next step and develop into ‘fourth generation universities’. Second, it is described how a process of co-creation between university and the health promotion practice has been developed, bottom up, at Tranzo, Scientific Center for Care and Wellbeing, Tilburg University, the Netherlands. The ideas developed by Steinbuch and the results of the bottom up processes in Tilburg are combined. Consequences of the Tilburg experiences for the characteristics of a fourth-generation university are discussed as well as consequences for the role of universities in society.

Gregory Steinberg completed his PhD at the University of Guelph, Canada, where he studied the role of leptin in muscle in the laboratory of Professor David Dyck. From 2002 to 2006, Greg was a postdoctoral fellow with Professor Bruce Kemp at St Vincent’s Institute of Medical Research, Australia, where he studied the role of the AMP-activated protein kinase (AMPK). In 2006, he started his academic career as Lecturer, Senior Research Fellow and Head of Metabolism at St Vincent’s Institute and the University of Melbourne. He returned to Canada in 2009 where his research studies cellular energy sensing mechanisms and looks at how endocrine factors, lipid metabolism and insulin sensitivity are linked and contribute to the development of obesity, type 2 diabetes, cardiovascular disease and cancer. He is the recipient of numerous awards, including the Diabetes Canada-Canadian Institutes of Health Research, Diabetes Young Scientist Award; the Endocrine Society Richard E Weitzman Outstanding Early Career Investigator Award; the Canadian Institutes of Health Research Gold Leaf Prize; and the American Diabetes Association Outstanding Scientific Achievement Award. To help celebrate the 100th anniversary of the discovery of insulin, Greg also recently took part in Diabetes Canada’s fitness fundraiser, ‘Lace Up for Diabetes’, riding 8000 km (the equivalent of crossing Canada) over a period of 80 days and raising almost $15,000 to help fund the next breakthrough discovery in the field. Coinciding with our issue theme of diabetes, which also marks the centenary of this discovery by Canadian scientists, The Biochemist spoke to Greg briefly about his work in this area.

Special needs dentistry, also known as special care dentistry, is a specialty of dentistry concerned with the oral health ofpeople who have intellectual disability, or who are affected by other medical, physical, or psychiatric issues. Their additionalneeds may be due directly to their impairment or disability, or to some aspect of their medical history that affects theiroral health, or because their social, environmental or cultural context disables them with reference to their oral health.1According to data from the Indonesian Medical Council, there was an increasing number of Indonesians experiencing chronicdiseases including cancer, stroke, heart disease, renal disease, and diabetes mellitus from 2013 to 2018.2Unfortunately, therewas no data describing other special needs condition aside from medically challenged. This absence of data might makedentists and authorities complacent about this need. Even in the developed country, we found that people with disabilitieswere rarely identified as a priority population group in the public health policy and practice.3Along with increasing awareness of parents and careers, supporting facilities and education such as physiotherapy, speechtherapy, management behavior are much in demand. Though, dental treatment is still not popular. They are prioritizinggeneral health instead of dental and oral health to support short term impact.4Meanwhile, special need persons are proneto poor oral health. People with developmental disabilities have higher rates of cavities, gum disease and tooth loss and thecause is often heartbreakingly simple.5Many of these persons are physically unable to brush their teeth, and many won’t allowsomeone else do it for them.6Others are hampered by medical conditions, or by the side effects of medications they take,which is why regular dental checkups and cleanings are so important.General dentists are reluctant of taking care of special need patientsWe recognized that there are only a few oral health professions that work to improve the oral health of people withspecial needs.7Not only is their access to care almost non-existent in comparison to the general population, but also thefacilities are inadequate and staff lack awareness of oral health matters that may impact those with special needs.8Moreover,parents and careers are confronted with different problems such as, dentists who lack skills and competency in managingpeople with disabilities. Dentists reported having difficulty treating such patients. The complexity in treating patients withspecial needs, the variety of medical conditions or disabilities that require more time or altered delivery methods than theroutine delivery of dental care for the general population,9and sometimes patients required special methods and techniquesto treat their oral health conditions has led to low preparedness and willingness of oral health professionals to treat patientswith special needs.10 It requires a holistic approach that is dentist led in order to meet the complex requirements of peoplewith impairments. It may impact access and thus their oral health, while other complications include inconvenient locationsof dental clinics, transport issues, and cost of dental treatment.11All patients with special needs should have equal access andhigh-quality treatment that focuses on patient safety, patient-centered care, and treatment of all dental needs. Thus, oral healthprofessional needs to have training or special education to handle patients with special needs in an effort to increase oral anddental health of this population.Dental student training improvement is neededIt is written in standard competency of Indonesian dental doctor released by Indonesian Medical Council thatundergraduate dental student must be able to ascertain congenital and hereditary abnormalities in oral cavity, and maintainingoral soft tissue health in patients with compromised medical condition. In fact, there are limitation of opportunity forthem to meet those special patients. Dentists who treat patients with special needs are dental pediatrics; there are no dentalspecialists who specifically manage patients who are adults with special needs.12 Furthermore, for the undergraduate basis,dental school are not well equipped with staff and tools to support that competency. Of the 11 dental schools that have beenaccredited ”A” in Indonesia, there are only 4 dental schools who have structured dental courses on taking care of oral and dentalhealth for person with special needs. This program is restricted to postgraduate student only. There is no syllabus or programfor undergraduate dental students. Lack of training and experience of undergraduate dental students in dealing with patientswith special needs was one of the most reported issues that inhibits the treatment of these patients. Therefore, the access ofdental student to gain knowledge and experience in this major should be improved.Indeed, it is well known that good oral health is conducive to overall well-being. Due to increasing demand of treatingspecial care persons with their complexities, oral health professionals need to improve their skill and knowledge. Tania Saskianti, DDS, PhD, Ped DentChairperson, Joint Scientific Meeting in Special Care DentistryLecturer, Department of Pediatric DentistryFaculty of Dental Medicine, Universitas Airlangga REFERENCES1. Friel S, Jamieson L. Political economy, trade relations and health inequalities: lessons from general health. Community Dent Health. 2019; 36(2),152–156 (2019).2. National Institute of Health Research and Development of Ministry of Health Indonesia. Main Result of Basic Health Research 2018. 2018.3. Victorian Health Promoting Foundation. Disability and health inequalities in Australia. VicHealth. 2012; 1–11.4. Anders PL, Davis EL. Oral health of patients with intellectual disabilities: A systematic review. Spec Care Dentist. 2010; 30(3):110–7.5. Minihan PM, Morgan JP, Park A, Yantsides KE, Nobles CJ, Finkelman MD, et al. At-home oral care for adults with developmental disabilities A surveyof caregivers. J Am Dent Assoc. 2014; 145(10):1018–25.6. Eijsink AM, Schipper G, Vermaire JH. A Q-methodology study among caregivers of people with moderate intellectual disabilities on their clients’health care: An example in oral health. J Appl Res Intellect. Disabil. 2018; 31(5):915–26.7. Wyne AH, Hammad N, Splieth C. Oral health knowledge of health care workers in special children’s center. Pak J Med Sci. 2015; 31(1):164–8.8. Hewson ND. Submission 552 - Australian Dental Association Inc - Disability Care and Support - Public inquiry. Aust Dent Assoc. 2010; 1–20.9. Wilson NJ, Lin Z, Villarosa A, Lewis P, Philip P, Sumar B, et al. Countering the poor oral health of people with intellectual and developmentaldisability: a scoping literature review. BMC Public Health. 2019; 19(1):1530.10. Alumran A, Almulhim L, Almolhim B, Bakodah S, Aldossary H, Alakrawi Z. Preparedness and willingness of dental care providers to treat patientswith special needs. Clin Cosmet Investig Dent. 2018; 10:231–6.11. Steinberg BJ. Issues and challenges in special care dentistry. J Dent Educ. 2005; 69:323–4.12. Vertel N, Harrison RL, Campbell KM. Access to Dental Services for Children with Special Health Care Needs: A Pilot Study at the DentalDepartment of BC Children’s Hospital. J Can Dent Assoc. 2017; 83:h6.

The ideas put forth here do not fit perfectly or entirely into the genre and form of what has established itself as the scholarly journal article. What is put forth, instead, is a juxtaposition of lines of thinking about the scholarly and popular in publishing, past, present and future. As such it may indeed be quite appropriate to the occasion and the questions raised in the call for papers for this special issue of M/C Journal. The ideas put forth here are intended as pieces of an ever-changing puzzle of the making public of scholarship, which, I hope, may in some way fit with both the work of others in this special issue and in the discourse more broadly. The first line of thinking presented takes the form of an historical overview of publishing as context to consider a second line of thinking about the current status and future of publishing. The historical context serves as reminder (and cause for celebration) that publishing has not yet perished, contrary to continued doomsday sooth-saying that has come with each new medium since the advent of print. Instead, publishing has continued to transform and it is precisely the transformation of print, print culture and reading publics that are the focus of this article, in particular, in relation to the question of the boundaries between the scholarly and the popular. What follows is a juxtaposition that is part of an investigation in progress. Presented first, therefore, is a mapping of shifts in print culture from the time of Gutenberg to the twentieth century; second, is a contemporary snapshot of the editorial mandates of more than one hundred member journals of the Canadian Association of Learned Journals (CALJ). What such juxtaposition is able to reveal is open to interpretation, of course. And indeed, as I proceed in my investigation of publishing past, present and future, my interpretations are many. The juxtaposition raises a number of issues: of communities of readers and the cultures of reading publics; of privileged and marginalised texts (as well as their authors and their readers); of access and reach (whether in terms of what is quantifiable or in a much more subtle but equally important sense). In Canada, at present, these issues are also intertwined with changes to research funding policies and some attention is given at the end of this article to the Social Sciences and Humanities Research Council (SSHRC) of Canada and its recent/current shift in funding policy. Curiously, current shifts in funding policies, considered alongside an historical overview of publishing, would suggest that although publishing continues to transform, at the same time, as they say, plus ça change, plus c’est la même chose. Republics of Letters and Ghosts in Machines Republics of Letters that formed after the advent of the printing press can be conjured up as distant and almost mythical communities of elite literates, ghosts almost lost in a Gutenberg galaxy that today encompasses (and is embodied in) schools, bookshelves, and digital archives in many places across the globe. Conjuring up ghosts of histories past seems always to reveal ironies, and indeed some of the most interesting ironies of the Gutenberg galaxy involve McLuhanesque reversals or, if not full reversals, then in the least some notably sharp turns. There is a need to define some boundaries (and terms) in the framing of the tracing that follows. Given that the time frame in question spans more than five hundred years (from the advent of Gutenberg’s printing press in the fifteenth century to the turn of the 21st century), the tracing must necessarily be done in broad strokes. With regard to what is meant by the “making public of scholarship” in this paper, by “making public” I refer to accounts historians have given in their attempts to reconstruct a history of what was published either in the periodical press or in books. With regard to scholarship (and the making public of it), as with many things in the history of publishing (or any history), this means different things in different times and in different places. The changing meanings of what can be termed “scholarship” and where and how it historically has been made public are the cornerstones on which this article (and a history of the making public of scholarship) turn. The structure of this paper is loosely chronological and is limited to the print cultures and reading publics in France, Britain, and what would eventually be called the US and Canada, and what follows here is an overview of changes in how scholarly and popular texts and publics are variously defined over the course of history. The Construction of Reading Publics and Print Culture In any consideration of “print culture” and reading publics, historical or contemporary, there are two guiding principles that historians suggest should be kept in mind, and, though these may seem self-evident, they are worth stating explicitly (perhaps precisely because they seem self-evident). The first is a reminder from Adrian Johns that “the very identity of print itself has had to be made” (2 italics in original). Just as the identity of print cultures are made, similarly, a history of reading publics and their identities are made, by looking to and interpreting such variables as numbers and genres of titles published and circulated, dates and locations of collections, and information on readers’ experiences of texts. Elizabeth Eisenstein offers a reminder of the “widely varying circumstances” (92) of the print revolution and an explicit acknowledgement of such circumstances provides the second, seemingly self-evident guiding principle: that the construction of reading publics and print culture must not only be understood as constructed, but also that such constructions ought not be understood as uniform. The purpose of the reconstructions of print cultures and reading publics presented here, therefore, is not to arrive at final conclusions, but rather to identify patterns that prove useful in better understanding the current status (and possible future) of publishing. The Fifteenth and Sixteenth Centuries—Boom, then Busted by State and Church In search of what could be termed “scholarship” following the mid-fifteenth century boom of the early days of print, given the ecclesiastical and state censorship in Britain and France and the popularity of religious texts of the 15th and 16th centuries, arguably the closest to “scholarship” that we can come is through the influence of the Italian Renaissance and the revival and translation (into Latin, and to a far lesser extent, vernacular languages) of the classics and indeed the influence of the Italian Renaissance on the “print revolution” is widely recognised by historians. Historians also recognise, however, that it was not long until “the supply of unpublished texts dried up…[yet for authors] to sell the fruits of their intellect—was not yet common practice before the late 16th century” (Febvre and Martin 160). Although this reference is to the book trade in France, in Britain, and in the regions to become the US and Canada, reading of “pious texts” was similarly predominant in the early days of print. Yet, the humanist shift throughout the 16th century is evidenced by titles produced in Paris in the first century of print: in 1501, in a total of 88 works, 53 can be categorised as religious, with 25 categorised as Latin, Greek, or Humanist authors; as compared to titles produced in 1549, in a total of 332 titles, 56 can be categorised as religious with 204 categorised as Latin, Greek, or Humanist authors (Febvre and Martin 264). The Seventeenth Century—Changes in the Political and Print Landscape In the 17th century, printers discovered that their chances of profitability (and survival) could be improved by targeting and developing a popular readership through the periodical press (its very periodicity and relative low cost both contributed to its accessibility by popular publics) in Europe as well as in North America. It is worthwhile to note, however, that “to the end of the seventeenth century, both literacy and leisure were virtually confined to scholars and ‘gentlemen’” (Steinberg 119) particularly where books were concerned and although literacy rates were still low, through the “exceptionally literate villager” there formed “hearing publics” who would have printed texts read to them (Eisenstein 93). For the literate members of the public interested not only in improving their social positions through learning, but also with intellectual (or spiritual or existential) curiosity piqued by forbidden books, it is not surprising that Descartes “wrote in French to a ‘lay audience … open to new ideas’” (Jacob 41). The 17th century also saw the publication of the first scholarly journals. There is a tension that becomes evident in the seventeenth century that can be seen as a tension characteristic of print culture, past and present: on the one hand, the housing of scholarship in scholarly journals as a genre distinct from the genre of the popular periodicals can be interpreted as a continued pattern of (elitist) divide in publics (as seen earlier between the oral and the written word, between Latin and the vernacular, between classic texts and popular texts); while, on the other hand, some thinkers/scholars of the day had an interest in reaching a wider audience, as printers always had, which led to the construction and fragmentation of audiences (whether the printer’s market for his goods or the scholar’s marketplace of ideas). The Eighteenth Century—Republics of Letters Become Concrete and Visible The 18th century saw ever-increasing literacy rates, early copyright legislation (Statute of Anne in 1709), improved printing technology, and ironically (or perhaps on the contrary, quite predictably) severe censorship that in effect led to an increased demand for forbidden books and a vibrant and international underground book trade (Darnton and Roche 138). Alongside a growing book trade, “the pulpit was ultimately displaced by the periodical press” (Eisenstein 94), which had become an “established institution” (Steinberg 125). One history of the periodical press in France finds that the number of periodicals (to remain in publication for three or more years) available to the reading public in 1745 numbered 15, whereas in 1785 this increased to 82 (Censer 7). With regard to scholarly periodicals, another study shows that between 1790 and 1800 there were 640 scientific-technological periodicals being published in Europe (Kronick 1961). Across the Atlantic, earlier difficulties in cultivating intellectual life—such as haphazard transatlantic exchange and limited institutions for learning—began to give way to a “republic of letters” that was “visible and concrete” (Hall 417). The Nineteenth Century—A Second Boom and the Rise of the Periodical Press By the turn of the 19th century, visible and concrete republics of letters become evident on both sides of the Atlantic in the boom in book publishing and in the periodical press, scholarly and popular. State and church controls on printing/publishing had given way to the press as the “fourth estate” or a free press as powerful force. The legislation of public education brought increased literacy rates among members of successive generations. One study of literacy rates in Britain, for example, shows that in the period from 1840–1870 literacy rates increased by 35–70 per cent; then from 1870–1900, literacy increased by 78–261 per cent (Mitch 76). Further, with the growth and changes in universities, “history, languages and literature and, above all, the sciences, became an established part of higher education for the first time,” which translated into growing markets for book publishers (Feather 117). Similarly the periodical press reached ever-increasing and numerous reading publics: one estimate of the increase finds the publication of nine hundred journals in 1800 jumping to almost sixty thousand in 1901 (Brodman, cited in Kronick 127). Further, the important role of the periodical press in developing communities of readers was recognised by publishers, editors and authors of the time, something equally recognised by present-day historians describing the “generic mélange of the periodical … [that] particularly lent itself to the interpenetration of language and ideas…[and] the verbal and conceptual interconnectedness of science, politics, theology, and literature” (Dawson, Noakes and Topham 30). Scientists recognised popular periodicals as “important platforms for addressing a non-specialist but culturally powerful public … [they were seen as public] performances [that] fulfilled important functions in making the claims of science heard among the ruling élite” (Dawson et al. 11). By contrast, however, the scholarly journals of the time, while also increasing in number, were becoming increasingly specialised along the same disciplinary boundaries being established in the universities, fulfilling a very different function of forming scholarly and discipline-specific discourse communities through public (published) performances of a very different nature. The Twentieth Century—The Tension Between Niche Publics and Mass Publics The long-existing tension in print culture between the differentiation of reading publics on the one hand, and the reach to ever-expanding reading publics on the other, in the twentieth century becomes a tension between what have been termed “niche-marketing” and “mass marketing,” between niche publics and mass publics. What this meant for the making public of scholarship was that the divides between discipline-specific discourse communities (and their corresponding genres) became more firmly established and yet, within each discipline, there was further fragmentation and specialisation. The niche-mass tension also meant that although in earlier print culture, “the lines of demarcation between men of science, men of letters, and scientific popularizers were far from clear, and were constantly being renegotiated” (Dawson et al 28), with the increasing professionalisation of academic work (and careers), lines of demarcation became firmly drawn between scholarly and popular titles and authors, as well as readers, who were described as “men of science,” as “educated men,” or as “casual observers” (Klancher 90). The question remains, however, as one historian of science asks, “To whom did the reading public go in order to learn about the ultimate meaning of modern science, the professionals or the popularizers?” (Lightman 191). By whom and for whom, where and how scholarship has historically been made public, are questions worthy of consideration if contemporary scholars are to better understand the current status (and possible future) for the making public of scholarship. A Snapshot of Scholarly Journals in Canada and Current Changes in Funding Policies The here and now of scholarly journal publishing in Canada (a growing, but relatively modest scholarly journal community, compared to the number of scholarly journals published in Europe and the US) serves as an interesting microcosm through which to consider how scholarly journal publishing has evolved since the early days of print. What follows here is an overview of the membership of the Canadian Association of Learned Journals (CALJ), in particular: (1) their target readers as identifiable from their editorial mandates; (2) their print/online/open-access policies; and (3) their publishers (all information gathered from the CALJ website, http://www.calj-acrs.ca/). Analysis of the collected data for the 100 member journals of CALJ (English, French and bilingual journals) with available information on the CALJ website is presented in Table 1 (below). A few observations are noteworthy: (1) in terms of readers, although all 100 journals identify a scholarly audience as their target readership, more than 40% of the journal also identify practitioners, policy-makers, or general readers as members of their target audience; (2) more than 25% of the journals publish online as well as or instead of print editions; and (3) almost all journals are published either by a Canadian university or, in one case, a college (60%) or a scholarly or professional society (31%). Table 1: Target Readership, Publishing Model and Publishers, CALJ Members (N=100) Journals with identifiable scholarly target readership 100 Journals with other identifiable target readership: practitioner 35 Journals with other identifiable target readership: general readers 18 Journals with other identifiable target readership: policy-makers/government 10 Total journals with identifiable target readership other than scholarly 43 Journals publishing in print only 56 Journals publishing in print and online 24 Journals publishing in print, online and open access 16 Journals publishing online only and open access 4 Journals published through a Canadian university press, faculty or department 60 Journals published by a scholarly or professional society 31 Journals published by a research institute 5 Journals published by the private sector 4 In the context of the historical overview presented earlier, this data raises a number of questions. The number of journals with target audiences either within or beyond the academy raises issues akin to the situation in the early days of print, when published works were primarily in Latin, with only 22 per cent in vernacular languages (Febvre and Martin 256), thereby strongly limiting access and reach to diverse audiences until the 17th century when Latin declined as the international language (Febvre and Martin 275) and there is a parallel to scholarly journal publishing and their changing readership(s). Diversity in audiences gradually developed in the early days of print, as Febvre and Martin (263) show by comparing the number of churchmen and lawyers with library collections in Paris: from 1480–1500 one lawyer and 24 churchmen had library collections, compared to 1551–1600, when 71 lawyers and 21 churchmen had library collections. Although the distinctions between present-day target audiences of Canadian scholarly journals (shown in Table 1, above) and 16th-century churchmen or lawyers no doubt are considerable, again there is a parallel with regard to changes in reading audiences. Similarly, the 18th-century increase in literacy rates, education, and technological advances finds a parallel in contemporary questions of computer literacy and access to scholarship (see Willinsky, “How,” Access, “Altering,” and If Only). Print culture historians and historians of science, as noted above, recognise that historically, while scholarly periodicals have increasingly specialised and popular periodicals have served as “important platforms for addressing a non-specialist but culturally powerful public…[and] fulfill[ing] important functions in making the claims of science heard among the ruling élite” (Dawson 11), there is adrift in current policies changes (and in the CALJ data above) a blurring of boundaries that harkens back to earlier days of print culture. As Adrian John reminded us earlier, “the very identity of print itself has had to be made” (2, italics in original) and the same applies to identities or cultures of print and the members of that culture: namely, the readers, the audience. The identities of the readers of scholarship are being made and re-made, as editorial mandates extend the scope of journals beyond strict, academic disciplinary boundaries and as increasing numbers of journals publish online (and open access). In Canada, changes in scholarly journal funding by the Social Sciences and Humanities Research Council (SSHRC) of Canada (as well as changes in SSHRC funding for research more generally) place increasing focus on impact factors (an international trend) as well as increased attention on the public benefits and value of social sciences and humanities research and scholarship (see SSHRC 2004, 2005, 2006). There is much debate in the scholarly community in Canada about the implications and possibilities of the direction of the changing funding policies, not least among members of the scholarly journal community. As noted in the table above, most scholarly journal publishers in Canada are independently published, which brings advantages of autonomy but also the disadvantage of very limited budgets and there is a great deal of concern about the future of the journals, about their survival amidst the current changes. Although the future is uncertain, it is perhaps worthwhile to be reminded once again that contrary to doomsday sooth-saying that has come time and time again, publishing has not perished, but rather it has continued to transform. I am inclined against making normative statements about what the future of publishing should be, but, looking at the accounts historians have given of the past and looking at the current publishing community I have come to know in my work in publishing, I am confident that the resourcefulness and commitment of the publishing community shall prevail and, indeed, there appears to be a good deal of promise in the transformation of scholarly journals in the ways they reach their audiences and in what reaches those audiences. Perhaps, as is suggested by the Canadian Centre for Studies in Publishing (CCSP), the future is one of “inventing publishing.” References Canadian Association of Learned Journals. Member Database. 10 June 2008 ‹http://www.calj-acrs.ca/>. Canadian Centre for Studies in Publishing. 10 June 2008. ‹http://www.ccsp.sfu.ca/>. Censer, Jack. The French Press in the Age of Enlightenment. London: Routledge, 1994. Darnton, Robert, Estienne Roche. Revolution in Print: The Press in France, 1775–1800. Berkeley: U of California P, 1989. Dawson, Gowan, Richard Noakes, and Jonathan Topham. Introduction. Science in the Nineteenth-century Periodical: Reading the Magazine of Nature. Ed. Geoffrey Cantor, Gowan Dawson, Richard Noakes, and Jonathan Topham. Cambridge: Cambridge UP, 2004. 1–37. Eisenstein, Elizabeth. The Printing Revolution in Early Modern Europe. Cambridge: Cambridge UP, 1983 Feather, John. A History of British Publishing. New York: Routledge, 2006. Febvre, Lucien, and Henri-Jean Martin. The Coming of the Book: The Impact of Printing 1450–1800. London: N.L.B., 1979. Jacob, Margaret. Scientific Culture and the Making of the Industrial West. New York: Oxford UP, 1997. Johns, Adrian. The Nature of the Book: Print and Knowledge in the Making. Chicago: U of Chicago P, 1998. Hall, David, and Hugh Armory. The Colonial Book in the Atlantic World. Cambridge: Cambridge UP, 2000. Klancher, Jon. The Making of English Reading Audiences. Madison: U of Wisconsin P, 1987. Kronick, David. A History of Scientific and Technical Periodicals: The Origins and Development of the Scientific and Technological Press, 1665–1790. New York: Scarecrow Press, 1961. ---. "Devant le deluge" and Other Essays on Early Modern Scientific Communication. Lanham: Scarecrow Press, 2004. Lightman, Bernard. Victorian Science in Context. Chicago: U of Chicago P, 1997. Mitch, David. The Rise of Popular Literacy in Victorian England: The Influence of Private choice and Public Policy. Philadelphia: U of Pennsylvania P, 1991. Social Sciences and Humanities Research Council. Granting Council to Knowledge Council: Renewing the Social Sciences and Humanities in Canada, Volume 1, 2004. Social Sciences and Humanities Research Council. Granting Council to Knowledge Council: Renewing the Social Sciences and Humanities in Canada, Volume 3, 2005. Social Sciences and Humanities Research Council. Moving Forward As a Knowledge Council: Canada’s Place in a Competitive World. 2006. Steinberg, Sigfrid. Five Hundred Years of Printing. London: Oak Knoll Press, 1996. Willinsky, John. “How to be More of a Public Intellectual by Making your Intellectual Work More Public.” Journal of Curriculum and Pedagogy 3.1 (2006): 92–95. ---. The Access Principle: The Case for Open Access to Research and Scholarship. Cambridge, MA: MIT Press, 2006. ---. “Altering the Material Conditions of Access to the Humanities.” Ed. Peter Trifonas and Michael Peters. Deconstructing Derrida: Tasks for the New Humanities. London: Palgrave Macmillan, 2005. 118–36. ---. If Only We Knew: Increasing the Public Value of Social-Science Research. New York: Routledge, 2000.

In the 1960s, especially in the West, art that was revelatory and art that was revealing operated at opposite ends of the aesthetic spectrum. On the side of the revelatory we can think of encounters synonymous with modernism, in which an expressionist painting was revelatory of the Freudian unconscious, or a Barnett Newman the revelatory intensity of the sublime. By contrast, the impulse to reveal in 1960s art was rooted in post-Duchampian practice, implicating artists as different as Lynda Benglis and Richard Hamilton, who mined the potential of an art that was without essence. If revelatory art underscored modernism’s transcendental conviction, critically revealing work tested its discursive rules and institutional conventions. Of course, nothing in history happens as neatly as this suggests, but what is clear is how polarized the language of artistic revelation was throughout the 1960s. With the international spread of minimalism, pop art, and fluxus, provisional reveals eventually dominated art-historical discourse. Aesthetic conviction, with its spiritual undertones, was haunted by its demystification. In the words of Donald Judd: “a work needs only to be interesting” (184).That art galleries could be sites of timely socio-political issues, rather than timeless intuitions undersigned by medium specificity, is one of the more familiar origin stories of postmodernism. Few artists symbolize this shift more than Hans Haacke, whose 2019 exhibition All Connected, at the New Museum, New York, examined the legacy of his outward-looking work. Born in Germany in 1936, and a New Yorker since 1965, Haacke has been linked to the term “institutional critique” since the mid 1980s, after Mel Ramsden’s coining in 1975, and the increased recognition of kindred spirits such as Mierle Laderman Ukeles, Michael Asher, Martha Rosler, Robert Smithson, Daniel Buren, and Marcel Broodthaers. These artists have featured in books and essays by the likes of Benjamin Buchloh, Hal Foster, and Yve-Alain Bois, but they are also known for their own contributions to art discourse, producing hybrid conceptions of the intellectual postmodern artist as historian, critic and curator.Haacke was initially fascinated by kinetic sculpture in the early 1960s, taking inspiration from op art, systems art, and machine-oriented research collectives such as Zero (Germany), Gruppo N (Italy) and GRAV (France, an acronym of Groupe de Recherche d’Art Visuel). Towards the end of the decade he started to produce more overtly socio-political work, creating what would become a classic piece from this period, Gallery-Goers’ Birthplace and Residence Profile, Part 1 (1969). Here, in a solo exhibition at New York’s Howard Wise Gallery, the artist invited viewers to mark their birthplaces and places of residence on a map. Questioning the statistical demography of the Gallery’s avant-garde attendees, the exhibition anticipated the meticulous sociological character of much of his practice to come, grounding New York art – the centre of the art world – in local, social, and economic fabrics.In the forward to the catalogue of All Connected, New Museum Director Lisa Philips claims that Haacke’s survey exhibition provided a chance to reflect on the artist’s prescience, especially given the flourishing of art activism over the last five or so years. Philips pressed the issue of why no other American art institution had mounted a retrospective of his work in three decades, since his previous survey, Unfinished Business, at the New Museum in 1986, at its former, and much smaller, Soho digs (8). It suggests that other institutions have deemed Haacke’s work too risky, generating too much political heat for them to handle. It’s a reputation the artist has cultivated since the Guggenheim Museum famously cancelled his 1971 exhibition after learning his intended work, Shapolsky et al. Manhattan Real Estate Holdings, A Real Time Social System as of May 1, 1971 (1971) involved research into dubious New York real estate dealings. Guggenheim director Thomas Messer defended the censorship at the time, going so far as to describe it as an “alien substance that had entered the art museum organism” (Haacke, Framing 138). Exposé was this substance Messer dare not name: art that was too revealing, too journalistic, too partisan, and too politically viscid. (Three years later, Haacke got his own back with Solomon R. Guggenheim Museum Board of Trustees, 1974, exposing then Guggenheim board members’ connections to the copper industry in Chile, where socialist president Salvador Allende had just been overthrown with US backing.) All Connected foregrounded these institutional reveals from time past, at a moment in 2019 when the moral accountability of the art institution was on the art world’s collective mind. The exhibition followed high-profile protests at New York’s Whitney Museum and Metropolitan Museum of Art, as well as at Sydney’s Museum of Contemporary Art, the Louvre, and the British Museum. These and other arts organisations have increasingly faced pressures, fostered by social media, to end ties with unethical donors, sponsors, and board members, with activist groups protesting institutional affiliations ranging from immigration detention centre management to opioid and teargas manufacturing. An awareness of the limits of individual agency and autonomy undoubtedly defines this era, with social media platforms intensifying the encumbrances of individual, group, and organisational identities. Hans Haacke, Gallery-Goers’ Birthplace and Residence Profile, Part 1, 1969 Hans Haacke, Gallery-Goers’ Birthplace and Residence Profile, Part 2, 1969-71Unfinished BusinessUnderscoring Haacke’s activist credentials, Philips describes him as “a model of how to live ethically and empathetically in the world today”, and as a beacon of light amidst the “extreme political and economic uncertainty” of the present, Trump-presidency-calamity moment (7). This was markedly different to how Haacke’s previous New York retrospective, Unfinished Business, was received, which bore the weight of being the artist’s first museum exhibition in New York following the Guggenheim controversy. In the catalogue to Haacke’s 1986 exhibition, then New Museum director Marcia Tucker introduced his work as a challenge, cautiously claiming that he poses “trenchant questions” and that the institution accepts “the difficulties and contradictions” inherent to any museum staging of his work (6).Philips’s and Tucker’s distinct perspectives on Haacke’s practice – one as heroically ethical, the other as a sobering critical challenge – exemplify broader shifts in the perception of institutional critique (the art of the socio-political reveal) over this thirty-year period. In the words of Pamela M. Lee, between 1986 and 2019 the art world has undergone a “seismic transformation”, becoming “a sphere of influence at once more rapacious, acquisitive, and overweening but arguably more democratizing and ecumenical with respect to new audiences and artists involved” (87). Haacke’s reputation over this period has taken a similar shift, from him being a controversial opponent of art’s autonomy (an erudite postmodern conceptualist) to a figurehead for moral integrity and cohesive artistic experimentation.As Rosalyn Deutsche pointed out in the catalogue to Haacke’s 1986 exhibition, a potential trap of such a retrospective is that, through biographical positioning, Haacke might be seen as an “exemplary political artist” (210). With this, the specific political issues motivating his work would be overshadowed by the perception of the “great artist” – someone who brings single-issue politics into the narrative of postmodern art, but at the expense of the issues themselves. This is exactly what Douglas Crimp discovered in Unfinished Business. In a 1987 reflection on the show, Crimp argued that, when compared with an AIDS-themed display, Homo Video, staged at the New Museum at the same time, reviewers of Haacke’s exhibition tended to analyse his politics “within the context of the individual artist’s body of work … . Political issues became secondary to the aesthetic strategies of the producer” (34). Crimp, whose activism would be at the forefront of his career in subsequent years, was surprised at how Homo Video and Unfinished Business spawned different readings. Whereas works in the former exhibition tended to be addressed in terms of the artists personal and partisan politics, Haacke’s prompted reflection on the aesthetics-politics juxtaposition itself. For Crimp, the fact that “there was no mediation between these two shows”, spoke volumes about the divisions between political and activist art at the time.New York Times critic Michael Brenson, reiterating a comment made by Fredric Jameson in the catalogue for Unfinished Business, describes the timeless appearance of Haacke’s work in 1986, which is “surprising for an artist whose work is in some way about ideology and history” (Brenson). The implication is that the artist gives a surprisingly long aesthetic afterlife to the politically specific – to ordinarily short shelf-life issues. In this mode of critical postmodernism in which we are unable to distinguish clearly between intervening in and merely reproducing the logic of the system, Haacke is seen as an astute director of an albeit ambiguous push and pull between political specificity and aesthetic irreducibility, political externality and the internalist mode of art about art. Jameson, while granting that Haacke’s work highlights the need to reinvent the role of the “ruling class” in the complex, globalised socio-economic situation of postmodernism, claims that it does so as representative of the “new intellectual problematic” of postmodernism. Haacke, according Jameson, stages postmodernism’s “crisis of ‘mapping’” whereby capitalism’s totalizing, systemic forms are “handled” (note that he avoids “critiqued” or “challenged”) by focusing on their manifestation through particular (“micro-public”) institutional means (49, 50).We can think of the above examples as constituting the postmodern version of Haacke, who frames very specific political issues on the one hand, and the limitless incorporative power of appropriative practice on the other. To say this another way, Haacke, circa 1986, points to specific sites of power struggle at the same time as revealing their generic absorption by an art-world system grown accustomed to its “duplicate anything” parameters. For all of his political intent, the artistic realm, totalised in accordance with the postmodern image, is ultimately where many thought his gestures remained. The philosopher turned art critic Arthur Danto, in a negative review of Haacke’s exhibition, portrayed institutional critique as part of an age-old business of purifying art, maintaining that Haacke’s “crude” and “heavy-handed” practice is blind to how art institutions have always relied on some form of critique in order for them to continue being respected “brokers of spirit”. This perception – of Haacke’s “external” critiques merely serving to “internally” strengthen existing art structures – was reiterated by Leo Steinberg. Supportively misconstruing the artist in the exhibition catalogue, Steinberg writes that Haacke’s “political message, by dint of dissonance, becomes grating and shrill – but shrill within the art context. And while its political effectiveness is probably minimal, its effect on Minimal art may well be profound” (15). Hans Haacke, MOMA Poll, 1970 All ConnectedSo, what do we make of the transformed reception of Haacke’s work since the late 1980s: from a postmodern ouroboros of “politicizing aesthetics and aestheticizing politics” to a revelatory exemplar of art’s moral power? At a period in the late 1980s when the culture wars were in full swing and yet activist groups remained on the margins of what would become a “mainstream” art world, Unfinished Business was, perhaps, blindingly relevant to its times. Unusually for a retrospective, it provided little historical distance for its subject, with Haacke becoming a victim of the era’s propensity to “compartmentalize the interpretive registers of inside and outside and the terms corresponding to such spatial­izing coordinates” (Lee 83).If commentary surrounding this 2019 retrospective is anything to go by, politics no longer performs such a parasitic, oppositional or even dialectical relation to art; no longer is the political regarded as a real-world intrusion into the formal, discerning, longue-durée field of aesthetics. The fact that protests inside the museum have become more visible and vociferous in recent years testifies to this shift. For Jason Farrago, in his review of All Connected for the New York Times, “the fact that no person and no artwork stands alone, that all of us are enmeshed in systems of economic and social power, is for anyone under 40 a statement of the obvious”. For Alyssa Battistoni, in Frieze magazine, “if institutional critique is a practice, it is hard to see where it is better embodied than in organizing a union, strike or boycott”.Some responders to All Connected, such as Ben Lewis, acknowledge how difficult it is to extract a single critical or political strategy from Haacke’s body of work; however, we can say that, in general, earlier postmodern questions concerning the aestheticisation of the socio-political reveal no longer dominates the reception of his practice. Today, rather than treating art and politics are two separate but related entities, like form is to content, better ideas circulate, such as those espoused by Bruno Latour and Jacques Rancière, for whom what counts as political is not determined by a specific program, medium or forum, but by the capacity of any actor-network to disrupt and change a normative social fabric. Compare Jameson’s claim that Haacke’s corporate and museological tropes are “dead forms” – through which “no subject-position speaks, not even in protest” (38) – with Battistoni’s, who, seeing Haacke’s activism as implicit, asks the reader: “how can we take the relationship between art and politics as seriously as Haacke has insisted we must?”Crimp’s concern that Unfinished Business perpetuated an image of the artist as distant from the “political stakes” of his work did not carry through to All Connected, whose respondents were less vexed about the relation between art and politics, with many noting its timeliness. The New Museum was, ironically, undergoing its own equity crisis in the months leading up to the exhibition, with newly unionised staff fighting with the Museum over workers’ salaries and healthcare even as it organised to build a new $89-million Rem Koolhaas-designed extension. Battistoni addressed these disputes at-length, claiming the protests “crystallize perfectly the changes that have shaped the world over the half-century of Haacke’s career, and especially over the 33 years since his last New Museum exhibition”. Of note is how little attention Battistoni pays to Haacke’s artistic methods when recounting his assumed solidarity with these disputes, suggesting that works such as Creating Consent (1981), Helmosboro Country (1990), and Standortkultur (Corporate Culture) (1997) – which pivot on art’s public image versus its corporate umbilical cord – do not convey some special aesthetico-political insight into a totalizing capitalist system. Instead, “he has simply been an astute and honest observer long enough to remind us that our current state of affairs has been in formation for decades”.Hans Haacke, News, 1969/2008 Hans Haacke, Wide White Flow, 1967/2008 Showing Systems Early on in the 1960s, Haacke was influenced by the American critic, artist, and curator Jack Burnham, who in a 1968 essay, “Systems Esthetics” for Artforum, inaugurated the loose conceptualist paradigm that would become known as “systems art”. Here, against Greenbergian formalism and what he saw as the “craft fetishism” of modernism, Burnham argues that “change emanates, not from things, but from the way things are done” (30). Burnham thought that emergent contemporary artists were intuitively aware of the importance of the systems approach: the significant artist in 1968 “strives to reduce the technical and psychical distance between his artistic output and the productive means of society”, and pays particular attention to relationships between organic and non-organic systems (31).As Michael Fried observed of minimalism in his now legendary 1967 essay Art and Objecthood, this shift in sixties art – signalled by the widespread interest in the systematic – entailed a turn towards the spatial, institutional, and societal contexts of receivership. For Burnham, art is not about “material entities” that beautify or modify the environment; rather, art exists “in relations between people and between people and the components of their environment” (31). At the forefront of his mind was land art, computer art, and research-driven conceptualist practice, which, against Fried, has “no contrived confines such as the theatre proscenium or picture frame” (32). In a 1969 lecture at the Guggenheim, Burnham confessed that his research concerned not just art as a distinct entity, but aesthetics in its broadest possible sense, declaring “as far as art is concerned, I’m not particularly interested in it. I believe that aesthetics exists in revelation” (Ragain).Working under the aegis of Burnham’s systems art, Haacke was shaken by the tumultuous and televised politics of late-1960s America – a time when, according to Joan Didion, a “demented and seductive vortical tension was building in the community” (41). Haacke cites Martin Luther King’s assassination as an “incident that made me understand that, in addition to what I had called physical and biological systems, there are also social systems and that art is an integral part of the universe of social systems” (Haacke, Conversation 222). Haacke created News (1969) in response to this awareness, comprising a (pre-Twitter) telex machine that endlessly spits out live news updates from wire services, piling up rolls and rolls of paper on the floor of the exhibition space over the course of its display. Echoing Burnham’s idea of the artist as a programmer whose job is to “prepare new codes and analyze data”, News nonetheless presents the museum as anything but immune from politics, and technological systems as anything but impersonal (32).This intensification of social responsibility in Haacke’s work sets him apart from other, arguably more reductive techno-scientific systems artists such as Sonia Sheridan and Les Levine. The gradual transformation of his ecological and quasi-scientific sculptural experiments from 1968 onwards could almost be seen as making a mockery of the anthropocentrism described in Fried’s 1967 critique. Here, Fried claims not only that the literalness of minimalist work amounts to an emphasis on shape and spatial presence over pictorial composition, but also, in this “theatricality of objecthood” literalness paradoxically mirrors (153). At times in Fried’s essay the minimalist art object reads as a mute form of sociality, the spatial presence filled by the conscious experience of looking – the theatrical relationship itself put on view. Fried thought that viewers of minimalism were presented with themselves in relation to the entire world as object, to which they were asked not to respond in an engaged formalist sense but (generically) to react. Pre-empting the rise of conceptual art and the sociological experiments of post-conceptualist practice, Fried, unapprovingly, argues that minimalist artists unleash an anthropomorphism that “must somehow confront the beholder” (154).Haacke, who admits he has “always been sympathetic to so-called Minimal art” (Haacke, A Conversation 26) embraced the human subject around the same time that Fried’s essay was published. While Fried would have viewed this move as further illustrating the minimalist tendency towards anthropomorphic confrontation, it would be more accurate to describe Haacke’s subsequent works as social-environmental barometers. Haacke began staging interactions which, however dry or administrative, framed the interplays of culture and nature, inside and outside, private and public spheres, expanding art’s definition by looking to the social circulation and economy that supported it.Haacke’s approach – which seems largely driven to show, to reveal – anticipates the viewer in a way that Fried would disapprove, for whom absorbed viewers, and the irreduction of gestalt to shape, are the by-products of assessments of aesthetic quality. For Donald Judd, the promotion of interest over conviction signalled scepticism about Clement Greenberg’s quality standards; it was a way of acknowledging the limitations of qualitative judgement, and, perhaps, of knowledge more generally. In this way, minimalism’s aesthetic relations are not framed so much as allowed to “go on and on” – the artists’ doubt about aesthetic value producing this ongoing temporal quality, which conviction supposedly lacks.In contrast to Unfinished Business, the placing of Haacke’s early sixties works adjacent to his later, more political works in All Connected revealed something other than the tensions between postmodern socio-political reveal and modernist-formalist revelation. The question of whether to intervene in an operating system – whether to let such a system go on and on – was raised throughout the exhibition, literally and metaphorically. To be faced with the interactions of physical, biological, and social systems (in Condensation Cube, 1963-67, and Wide White Flow, 1967/2008, but also in later works like MetroMobiltan, 1985) is to be faced with the question of change and one’s place in it. Framing systems in full swing, at their best, Haacke’s kinetic and environmental works suggest two things: 1. That the systems on display will be ongoing if their component parts aren’t altered; and 2. Any alteration will alter the system as a whole, in minor or significant ways. Applied to his practice more generally, what Haacke’s work hinges on is whether or not one perceives oneself as part of its systemic relations. To see oneself implicated is to see beyond the work’s literal forms and representations. Here, systemic imbrication equates to moral realisation: one’s capacity to alter the system as the question of what to do. Unlike the phenomenology-oriented minimalists, the viewer’s participation is not always assumed in Haacke’s work, who follows a more hermeneutic model. In fact, Haacke’s systems are often circular, highlighting participation as a conscious disruption of flow rather than an obligation that emanates from a particular work (148).This is a theatrical scenario as Fried describes it, but it is far from an abandonment of the issue of profound value. In fact, if we accept that Haacke’s work foregrounds intervention as a moral choice, it is closer to Fried’s own rallying cry for conviction in aesthetic judgement. As Rex Butler has argued, Fried’s advocacy of conviction over sceptical interest can be understood as dialectical in the Hegelian sense: conviction is the overcoming of scepticism, in a similar way that Geist, or spirit, for Hegel, is “the very split between subject and object, in which each makes the other possible” (Butler). What is advanced for Fried is the idea of “a scepticism that can be remarked only from the position of conviction and a conviction that can speak of itself only as this scepticism” (for instance, in his attempt to overcome his scepticism of literalist art on the basis of its scepticism). Strong and unequivocal feelings in Fried’s writing are informed by weak and indeterminate feeling, just as moral conviction in Haacke – the feeling that I, the viewer, should do something – emerges from an awareness that the system will continue to function fine without me. In other words, before being read as “a barometer of the changing and charged atmosphere of the public sphere” (Sutton 16), the impact of Haacke’s work depends upon an initial revelation. It is the realisation not just that one is embroiled in a series of “invisible but fundamental” relations greater than oneself, but that, in responding to seemingly sovereign social systems, the question of our involvement is a moral one, a claim for determination founded through an overcoming of the systemic (Fry 31).Haacke’s at once open and closed works suit the logic of our algorithmic age, where viewers have to shift constantly from a position of being targeted to one of finding for oneself. Peculiarly, when Haacke’s online digital polls in All Connected were hacked by activists (who randomized statistical responses in order to compel the Museum “to redress their continuing complacency in capitalism”) the culprits claimed they did it in sympathy with his work, not in spite of it: “we see our work as extending and conversing with Haacke’s, an artist and thinker who has been a source of inspiration to us both” (Hakim). This response – undermining done with veneration – is indicative of the complicated legacy of his work today. Haacke’s influence on artists such as Tania Bruguera, Sam Durant, Forensic Architecture, Laura Poitras, Carsten Höller, and Andrea Fraser has less to do with a particular political ideal than with his unique promotion of journalistic suspicion and moral revelation in forms of systems mapping. It suggests a coda be added to the sentiment of All Connected: all might not be revealed, but how we respond matters. 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