Dissertations / Theses: 'Statu'

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Dupont, Bernard. "L’ Etat et les casinos : imperturbable maintien du statu quo." Perpignan, 2008. http://www.theses.fr/2008PERP0841.

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Bruistens, Joannes. "Dissertatio juris naturalis inauguralis, de libertate commerciorum ex statu communionis primaevae derivanda." Leiden : IDC, 1985. http://catalogue.bnf.fr/ark:/12148/cb37256984h.

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Mortelaro, Priscila Kiselar. "Versões de aborto voluntário em projetos de lei: (im)possibilidades de superação do statu quo." Pontifícia Universidade Católica de São Paulo, 2017. https://tede2.pucsp.br/handle/handle/20724.

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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
The central aim of this research is to identify the versions of voluntary abortion present in the legislative process through the analysis of two specific bills, which propose either decriminalization or criminalization of such procedure even in the cases already provided by law: bills number 882/2015 and 478/2007, respectively. To understand the conditions that enable the criminalization of the ending of pregnancy, we will make use of Foucault’s theory concerning biopolitics and the apparatus (“dispositif”) of sexuality, since it allows us to conceive the rise of the process which politicizes maternity from the perspective of the life-imperative. To reach the aforementioned aim, we employ the theoretical-methodological approach from the discursive psychology, developed by the Centre for Studies and Research of Discursive Practices in Quotidian: rights, risks and health” (Núcleo de Estudos e Pesquisas sobre Práticas Discursivas no Cotidiano: direitos, riscos e saúde - NUPRAD), also related to a constructionist attitude. In the first place, we carried out a systematization of legislative bills with regard to abortion proposed between 2007 and 2017. Next, an analysis of the justification of the two selected bills was made, searching for the voluntary abortion versions contained in them. Three versions were then identified: abortion as murder, abortion as a public health problem and abortion as a women’s right, which, in turn, involves the right to reproductive self-determination and the right to life. These versions establish between themselves oppositions, but also combine and complement each other, depending on their use
Esta pesquisa tem como objetivo central identificar as versões de aborto voluntário presentes no processo legislativo por meio da análise de dois projetos de lei específicos que têm por foco a descriminalização ou a criminalização da prática nos casos já previstos por lei: o PL 882/2015 e o PL 478/2007, respectivamente. Para entendermos as condições que possibilitam a criminalização da interrupção da gestação, utilizaremos as teorizações de Michel Foucault acerca da biopolítica e do dispositivo da sexualidade, uma vez que nos permitem compreender a emergência do processo de politização da maternidade a partir do imperativo da vida. Para atingir o objetivo de pesquisa, empregamos a abordagem teórico-metodológica da psicologia discursiva desenvolvida no Núcleo de Estudos sobre Práticas Discursivas no Cotidiano: direitos, riscos e saúde (NUPRAD), que se inscreve no âmbito de uma postura construcionista. Em um primeiro momento, realizamos uma sistematização dos projetos de lei concernentes ao aborto apresentados no período de 2007 a 2017. Em seguida, foi feita uma análise da justificativa dos dois projetos de lei selecionados, buscando as versões de aborto voluntário neles presentes. Três versões foram identificadas: o aborto como assassinato, o aborto como problema de saúde pública e o aborto como direito feminino que, por sua vez, contempla o direito à autodeterminação reprodutiva e o direito à vida. Versões que estabelecem entre si relações de oposição, mas também se associam e completam, dependendo de seu uso

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BENTAALLAH, MOHAMMED EL AMINE. "Contribution to the study of Posidonia oceanica through the West Algerian coasts: localisation, characterisation and use for coastal water status assessment." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/180844.

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Posidonia oceanica è una specie endemica mediterranea che forma prati denso ad ampio, che fornisce importanti funzioni e servizi ecologici e supporta una comunità ricca e diversificata, comprese le specie di interesse economico. Nonostante la sua importanza, la distribuzione e la caratterizzazione dei prati di seagrass Posidonia oceanica sono stati scarsamente documentati e poco studiati nella parte meridionale del bacino del Mediterraneo, attraverso le coste algerine. Tuttavia, negli ultimi anni, vi è stato un interesse crescente per lo studio della P. oceanica attraverso la costa algerina, principalmente concentrata nella regione di Algeri. Secondo le nostre indagini sulla letteratura, dal 2000 fino ad oggi, solo pochi documenti descrivono alcuni aspetti della P. oceanica nell'Algeria occidentale, soprattutto letteratura grigia scritta in francese. La distribuzione dettagliata rimane in gran parte sconosciuta. Inoltre, alcune mappe e dati di punta hanno contribuito a documentare la distribuzione dei letti lungo le coste algarie occidentali. Le nostre indagini su 12 zone in quattro Wilaya (distretti), dall'Algeria occidentale (Chlef, Mostaganem, Orano e Ain Temouchent) combinate con dati di letteratura provenienti da diverse fonti, prevedono che la P. oceanica sia più rappresentata nell'Algeria occidentale con una discontinuità attraverso le coste. Uno studio sulla fenologia dei prati di Posidonia oceanica è stato condotto su cinque zone sui costi algerini occidentali (Zimba, Arzew, Stidia, Capo russo, Cap carbon) che forniscono nuovi dati sulla densità, il numero di foglie, la lunghezza del foglio, la superficie del foglio e lo stato degli apici determinate dal "coefficiente A". I risultati hanno mostrato informazioni sullo stato di salute del prato di P. oceanica attraverso queste zone. Secondo (Pergent et al. 1995), classificazione dei prati del 1995 hanno una densità anormale, questi possono essere dovuti alla profondità di campionamento che non supera 3m. D'altra parte, le densità media nei siti di Arzew e Zimba erano inferiori, che sembrano indicare una fonte di perturbazioni più generale. Altrove, per la valutazione dello stato delle acque costiere, sono stati sviluppati e applicati molti indici (sistemi di classificazione) basati sulla Posidonia oceanica (un elemento biologico di qualità secondo la direttiva quadro UE sull'acqua) nella parte nord del Mediterraneo occidentale e solo pochi di loro sono state applicate e testate nel bacino sud del Mediterraneo. Al fine di colmare il divario, abbiamo utilizzato un indice ecologico (BiPo) basato su quattro descrittori di P. oceanica per valutare lo stato ecologico delle acque costiere in due località della costa algerina occidentale: Stidia a Mostaganem e Cap Blanc ad Oran. I risultati mostrano che su una scala varia da "Cattivo" a "Alto", i valori dei rapporti di qualità ecologica (Ecological Quality Ratio: EQR) utilizzando la BiPo Le zone di acque di carbonio di Cap Carbon circondato in 'Buono' secondo la scala BiPo, la qualità dell'acqua di Stidia è stata classificata come 'Alto'. La qualità dell'acqua di Stidia è stata classificata come 'High'. Utilizzando questo indice e l'indice PREI di Boumaza (Boumaza et al. 2015) ha raccomandato l'utilizzo di PREI per una più adatta per valutare lo stato ecologico delle acque costiere di Algeri. I dati presentati in questo lavoro di tesi sono stati raccolti su un sito limitato di distribuzione dei prati P. oceanica. Uno studio che copre una quantità relativamente elevata di siti e descrittori è necessario per colmare attentamente il divario sulla situazione di P. oceanica attraverso le coste algerine.
Posidonia oceanica is a Mediterranean endemic species that forms dense and extensive meadows, providing important ecological functions and services and supporting a rich and diversified community, including species of economic interest. Despite its important, the seagrass Posidonia oceanica meadows distribution and characterisation were poorly documented and scarcely studied in the southern part of the Mediterranean basin, through the Algerian coasts. However, in the last few years, there has been a little growing interest to the study of the P. oceanica through the Algerian coast, primarily centred in Algiers region. According to our literature investigations, from 2000 to date, only few documents described some aspects of the P. oceanica in Western Algeria, mainly grey literature written in French. The detailed distribution remains largely unknown. Furthermore, some maps and point data helped document the distribution of beds along the west Algerian coasts. Our investigations on 12 zones in four Wilaya (districts), from the western Algeria (Chlef, Mostaganem, Oran and Ain Temouchent) combined to literature data from different sources, provides that the P. oceanica is more represented in western Algeria with a discontinuity through the coasts. A study of the phenology of Posidonia oceanica meadows was conducted on five zones on the west Algerian costs (Zimba, Arzew, Stidia, Capo russo, Cap carbon) providing new data on density, leaf number, leaf length, leaf surface and the state of the apexes as determined by the "coefficient A". The outcomes showed information about the health status of the P. oceanica meadow through these zones. According to (Pergent et al. 1995) classification meadows have abnormal density, these can be due to the sampling depth that do not exceed 3m. On the other hand, mean densities in Arzew and Zimba sites, were lower, which would appear to indicate a more general source of perturbation. Elsewhere, for the assessment of coastal waters status, many indices (classification systems) based on the Posidonia oceanica (a Biological Quality Element according to the EU Water Framework Directive) have been developed and applied in the North part of Western Mediterranean, and only few of them have been applied and tested in the south Mediterranean basin. In order to fill the gap, we made use of an ecological index (BiPo) based of four P. oceanica descriptors to assess the ecological status of coastal water in two localities from west Algerian coasts: Stidia in Mostaganem and Cap Blanc in Oran. Results show that on a scale ranges from ‘Bad’ to ‘High’, the Ecological Quality Ratio EQR values using BiPo ranged Cap Carbon area waters body in ‘Good’ according to BiPo scale, Stidia water quality has been classified as ‘High’. Using this index and PREI index Boumaza (Boumaza et al. 2015) recommended the use of PREI for more suitable for assessing the ecological status of Algiers coastal waters. Data presented in this thesis work have been collected on a limited P. oceanica meadow distribution sites. A study covering a relatively large amount of sites and descriptors is necessary to carefully fill the gap on the P. oceanica situation trough the Algerian coasts.

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Comer, Clémentine. "En quête d'égalité(s). La cause des agricultrices en Bretagne entre statu quo conjugal et ajustement catégoriel." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1G038.

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Cette recherche interroge les conditions de structuration et de perduration d’un engagement séparé pour les femmes dans les organisations et au sein de mobilisations agricoles bretonnes. Majoritairement composés d’exploitantes installées en couple et situés à la frontière entre associations de défense de l’égalité, cercles de sociabilités professionnelles et groupes de parole, les espaces d’encadrement agricole féminins offrent une occasion idoine de questionner non seulement l’imbrication des identités professionnelles et conjugales dans l’engagement mais également la labilité des usages rhétoriques de l'égalité et du féminisme dans des espaces professionnels non-mixtes. L’analyse de leur position dans l’espace de la représentation agricole questionne le degré d’autonomie des revendications portées au nom des agricultrices, leur influence sur les agendas organisationnels et leur effet sur la construction des carrières militantes. L’enquête s’appuie sur un dispositif cumulant une observation de quatre années des activités formelles et informelles des groupes féminins, une étude de leur documentation professionnelle, un recensement de leurs tribunes dans la presse agricole, auxquels s’ajoutent la réalisation d’entretiens avec les actrices qui y sont engagées et la constitution de données statistiques relatives aux mandats féminins dans les organisations agricoles bretonnes depuis 1990. Sur la base d’une analyse croisant les études de genre, la sociologie du militantisme et celle de la représentation professionnelle agricole, notre thèse consiste à démontrer que les groupes et mobilisations d’agricultrices forgent les contours d’une « cause de femmes » agricole mise sous tutelle des intérêts catégoriels et chevillée à l’idéal normatif de la complémentarité des sexes. En tant que réceptacles de positions professionnelles, organisationnelles et conjugales entrecroisées, les espaces de l’engagement féminin produisent des politisations ambivalentes de ces appartenances multiples, à la fois porteuses de contestation comme de reproduction des hiérarchies sexuées et de l’ordre social et politique
This research looks into the conditions for the structuring and continuation of a separate female activism within Breton organisations and farmers mobilisations. Mainly made up of professionals living in couples and situated at the intersection between gender equality advocacy groups, professional networks and support groups, farming self-help groups are a case in point to question not only the intertwining of professional and marital identities within activism but also the lability of rhetorical uses of equality and feminism within women-only professional spaces. The analysis of their position within the farmers’ representation spaces makes it compelling to question the degree of autonomy of the claims made in the name of women farmers, their influence upon the setting of professional agendas and their impact on the development of activist careers.Evidence was collected through an apparatus which consisted in the addition of a four-year-long observation of female groups’ formal and informal activities, an analysis of their professional literature, an inventory of their opinion columns inside the farm press, to which can be added semi-structured interviews with women farmers engaged in this activism and the setting up of statistical data about female mandates within Breton farm organisations since the 1990s. Drawing on an analysis which mixes gender studies, sociology of militancy and studies of farming professional representation, this PhD aims to demonstrate that women farmers groups and mobilisations shape the features of a farming “women cause” although it is subordinated to corporatist interests and seen through the lenses of the normative ideal of complementarity between the sexes. Being a repository of interlinked professional, organisational and matrimonial standpoints, female activism spaces lead to the ambivalent politicisation of plural belongings. These multiple affiliations can be a catalyst for protest as well as a way to reproduce sexual hierarchies and social and political order

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Statu, Nicolae Cristian [Verfasser], and Rudolf [Akademischer Betreuer] Wagner. "Contributions to the Study of Yang Xiong’s 揚雄 Fayan 法言 / Nicolae Cristian Statu ; Betreuer: Rudolf Wagner." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1201647339/34.

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Jacquet, Rojas Francisco. "Une théologie trinitaire in statu nascendi : l'avènement d'une poétique théâtrale du corps et du geste selon l'Évangile de Jean." Thesis, Paris 3, 2013. http://www.theses.fr/2013PA030075/document.

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Notre recherche se situe sur la base d’une approche interdisciplinaire venant à la fois de l’art vivant du théâtre – avec la notion de théâtralité – et de la phénoménologie du corps selon Maurice Merleau-Ponty, laquelle nous permet d’accomplir une lecture phénoménologique de la théâtralité du geste présente dans le récit johannique pour penser une théologie poétique du geste. Nous reconnaissons une autorité première au récit johannique pour y discerner l’apparition d’un logos de la relation entre le Père, le Fils et l’Esprit Saint en lien avec les disciples. L’horizon de notre recherche relève d’une poétique du geste. Nous cherchons à resituer la poétique dans son sens premier de l’acte de faire (poiein) qui désigne une opération expressive du corps en train de s’accomplir. Cette lecture de la poétique en tant qu’acte en train de se faire, nous permet de reconnaître un logos sous-jacent au geste qui se montre et se fait connaître en son état naissant. Une telle poétique concerne la théâtralité du corps. En effet, nous ne nous limitons pas à explorer le phénomène de la théâtralité corporelle sous-jacent au récit johannique (l’analyse de la théâtralité), mais nous cherchons à reconnaître une pensée poétique du corps qui se montre in statu nascendi à travers la théâtralité johannique
Our study utilizes an interdisciplinary approach emerging from both the living art of theater - with its implicit notion of theatricality - and Maurice Merleau-Ponty’s phenomenology of the body. This double approach allows for a phenomenological reading of the theatrical gesture found throughout the Johannine narrative. We can then proceed from there in our foundation of a poetical theology of the gesture. We begin by recognizing the Johannine narrative’s primary authority: there we discern the emergence of the logos of the relationship between the Father, the Son and the Holy Spirit in connection with the disciples. This particular discernment takes place against the broader horizon of a poetics of the gesture. We then resituate the ‘poetic’ in its etymological sense as ‘the act of doing or making (poiein)’. This originating context highlights the ‘poetical’ as an expressive action of the body that is in process toward completion. This reading of the poetic as an action in the process of making [or doing] then allows us to recognize a logos underlying the bodily gesture that reveals itself and makes itself known in its nascent state. Such a poetics concerns the very theatricality of the body itself. Indeed, we do not limit ourselves to exploring the phenomenon of bodily theatricality underlying the Johannine narrative (i.e., an analysis of theatricality). Rather, we seek to uncover a poetical thought of the body manifesting itself in its nascent state – in statu nascendi – by means of Johannine theatricality

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Stolojan-Filipesco, Vladimir. "Le statu-quo de la mémoire nationale à Taïwan : les dynamiques antagonistes de mises en récits publiques de l'expérience autoritaire." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC144.

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Le statu-quo de la mémoire nationale à Taiwan : les dynamiques antagonistes de mise en récits de l’expérience autoritaireresume :Cette thèse a comme origine l’apparente contradiction des politiques de la mémoire dédiées au régime de parti unique mis en place par le Parti nationaliste chinois (KMT) en 1945. Colonie japonaise depuis 1895, Taiwan passe alors sous le contrôle de la République de Chine au lendemain de la Seconde guerre mondiale. L’île sert de refuge aux nationalistes chinois en 1949, lorsqu’est actée la victoire des troupes maoïstes suite à la reprise de la guerre civile chinoise après 1945. En exil, le KMT, refusant de reconnaître sa défaite, gouverne Taiwan à travers un régime pensé pour représenter symboliquement toute la Chine. Les politiques identitaires et mémorielles d’alors valorisent uniquement les expériences historiques d’une communauté minoritaire au sein de la population taiwanaise, celle des insulaires venus de Chine à Taiwan avec le KMT entre 1945 et 1950. Cette fiction politique prend fin avec la démocratisation. Débutant en 1987, celle-ci voit l’affirmation d’un nouveau paradigme identitaire articulé autour des spécificités de Taiwan et son multiculturalisme, la Chine n’étant plus le référent central. Les victimes de la répression policière de l’ère autoritaire sont peu à peu reconnues. S’il perd rapidement sa prééminence, l’ancien récit officiel ne disparaît pas pour autant, une fraction de la population insulaire continuant de se reconnaître en une partie des représentations qui y sont inscrites. De même, le KMT, qui reste un des acteurs dominants la scène politique taiwanaise après la démocratisation, se refuse à tout véritable retour critique sur sa propre histoire pour éviter de mettre en danger sa propre légitimité. Plutôt que marquer une rupture nette avec l’ère autoritaire, les politiques de la mémoire post-1987 aboutissent à l’institutionnalisation de dispositifs reconnaissant les victimes de la dictature et d’autres à la gloire des anciens dirigeants, que ce soit Chiang Kai-shek ou son fils Chiang Ching-kuo. En adoptant une démarche relevant de la sociologie de la mémoire, notre recherche a pour but d’analyser les dynamiques soutenant la mise en place de nouveaux récits publics sur la période autoritaire après la démocratisation. L’objet de notre travail est d’expliquer les principales luttes mémorielles actuelles engageant la place qu’occuperait dans l’histoire taiwanaise le régime autoritaire du KMT, ce tout en interrogeant la notion de mémoire nationale
The key focus of this thesis is the exploration of the contradictory nature of the politics of memory dedicated to the Party-State system implemented by the Chinese Nationalist party (KMT) in 1945.In the aftermath of World War II, Taiwan – a Japanese colony since 1895 – sees its sovereignty transferred to the Republic of China.The country becomes the home to Chinese nationalist refugees and the last stronghold of the Kuomintang (KMT), after the party’s defeat against the communist forces during the Chinese civil war of 1949. Refusing to recognize its demise, the KMT rules Taiwan through a regime conceived to, symbolically, represent China in its entirety. During this period, the politics of memory and identity take into account the experiences of a minority within the Taiwanese community only – those of the Chinese population that came to Taiwan with the KMT between 1945 and 1950. This ends with the democratization of Taiwan in 1987. From this point onwards, China is no longer the central point of reference; a new identity paradigm arises, articulated around the specificities of Taiwan, and its multiculturalism.While the old official discourse quickly loses its prominence in modern day Taiwan, it doesn’t disappear completely, with a portion of the population still identifying itself with the old KMT narrative. Likewise, the KMT remains one of the key players on the Taiwanese political scene; the party never took an overly critical stance on its own history as it undermines its own legitimacy. Instead of breaking from the authoritarian era, the post 1987 politics of memories result in the contradicting recognition of both the victims of the dictatorship and the glory of the oldr ulers, Chiang Kai-shek and his son ChiangChing-kuo. Through following a sociology of memory approach, this research aims at analysing the dynamics behind the development of the new post-democratisation public narratives. This study investigates the current opposing takes on national memory, looking at the place the KMT’s authoritarian regime occupies in the Taiwanese history, while also redefining the concept of national memory

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Rubio, Mifsud Aurora Inmaculada. "La Pintura Mural Gòtica Lineal a Territori Valencià. Statu Quo del corpus conegut. Estudi i Anàlisi per a la Seua Conservació." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/59466.

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[EN] This paper presents the study of the corpus of mural paintings of the initial gothic period, existing in the contemporary territory of the Valencian Community, from a technical viewpoint, both stylistically as material. Most of these group of mural paintings have been hidden and therefore ignored for ages, behind walls or under layers of plaster and over paintings. This findings, most of the times by chance, happened during the refurbishment of buildings that generally had a ruinous state. This fact determines that, by the conservation conditions, the pathologies that these mural paintings present may be different to other works with similar technical features. The picture groups are individually analyzed, identifying their historical and geographical circumstances, background and references to other arts, and the study of the conservation status, mode of the crafting and the materials components analysis. Each of the groups are identified and catalogued, with all their characteristic features, to elaborate a comparative study of them, in order to find common lines that define the existing corpus. An historical and technical itinerary through the valencian mural gothic painting is developed, as well as a study of the original execution, composition of the materials on the mural holder and the pictorial layer, with which determine different trends and influences, depending on the geographical areas where they are located.
[ES] Este trabajo presenta el estudio del corpus de pinturas murales del periodo gótico inicial, existentes en el actual territorio de la Comunidad Valenciana, desde una óptica técnica, tanto a nivel estilístico como matérico. La mayor parte de estos conjuntos pictóricos han estado ocultos y por tanto ignorados durante largo tiempo, tras muros o bajo capas de enlucidos y pinturas superpuestas. Sus descubrimientos, la mayor parte de las veces fortuitos, se produjeron durante obras de remodelación en edificios que presentaban generalmente un estado ruinoso. Este hecho determina que, por las condiciones de conservación, las patologías que presentan sean diferentes a otras obras con características técnicas similares. Se analizan individualmente los conjuntos pictóricos, identificando circunstancias históricas y geográficas, antecedentes y referencias en otras artes, además del estudio del estado de conservación, el modo de factura y la analítica de componentes. Se identifican y catalogan cada uno de los conjuntos con todos sus trazos característicos, para pasar posteriormente a realizar un estudio comparativo entre ellos, con el fin de encontrar trazos comunes que definen el corpus existente. Se hace un recorrido histórico y técnico por la pintura mural gótica, un estudio de las técnicas de ejecución originales, la composición de los materiales en los soportes murales y la capa pictórica, con las cuales determinar diversas tendencias e influencias, dependiendo de las zonas geográficas donde se encuentran.
[CAT] Aquest treball presenta l'estudi del corpus de pintures murals del període inicial del gòtic, existents a l'actual territori de la Comunitat Valenciana, des d'un punt de vista tècnic, a nivell estilístic i matèric. La major part d'aquests conjunts pictòrics han estat ocults i per tant ignorats durant molts anys, rere murs o baix capes de lluïts i pintures superposades. Els seus descobriments, la majoria de les vegades fortuïts, succeïren durant obres de remodelació en edificis que presentaven generalment un estat ruïnós. Aquest fet determina que, per les condicions de conservació, les patologies que presenten siguen diferents a altres obres amb característiques tècniques semblants. S'analitzen individualment els conjunts pictòrics, identificant circumstàncies històriques i geogràfiques, antecedents i referències en altres arts; a més s'estudia l'estat de conservació, el mode de factura i l'analítica dels materials compositius. S'identifiquen i cataloguen cadascun dels conjunts amb tots els seus trets característics, per a passar posteriorment a realitzar un estudi comparatiu entre ells, per tal de trobar trets comuns que defineixen el corpus existent. Es fa un recorregut històric i tècnic per la pintura mural gòtica, un estudi de les tècniques d'execució originals, la composició dels materials en els suports murers i la capa pictòrica, amb les quals determinar les diverses tendències i influències, depenent-hi de les zones geogràfiques on es troben.
Rubio Mifsud, AI. (2015). La Pintura Mural Gòtica Lineal a Territori Valencià. Statu Quo del corpus conegut. Estudi i Anàlisi per a la Seua Conservació [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/59466
TESIS

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Gaubert, Cécile. "Rôles des jugements de compétence et d'assertivité dans la justification de la hièrarchie sociale." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAG033.

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Cette thèse interroge notre façon de percevoir et de justifier les différences de statut dans la société. La littérature montre que le jugement social repose sur deux dimensions fondamentales, une dimension horizontale, qui fait référence aux qualités permettant d’entretenir de bonnes relations sociales, et une dimension verticale, qui fait référence aux qualités permettant d’atteindre ses objectifs. Cette dimension verticale, liée au statut, est composée de deux facettes : l’assertivité, i.e. la motivation à réussir et à se développer et la compétence, i.e. les ressources pour réaliser ses objectifs. Notre objectif était de mettre en évidence que seule la compétence permet de justifier la hiérarchie sociale. Nous avons réalisé huit études, qui ont confirmé notre hypothèse. Ainsi, plus les personnes justifient les inégalités, plus elles attribuent de compétence aux personnes ayant un statut élevé dans la société (i.e. riches, les personnes de pouvoir). Par ailleurs la relation entre l’assertivité et le statut n’a pas été modérée par la justification du système, suggérant que l’assertivité ne permet pas de justifier des différences de statut
This thesis questions the perception and justification of status differences in society. The literature shows that social judgment is based on two fundamental dimensions : a horizontal dimension, which refers to qualities that enable good social relations to be maintained, and a vertical dimension, which refers to qualities that enable objectives to be achieved. This vertical dimension, linked to status, is composed of two facets: assertiveness, i.e. the motivation to succeed and develop, and competence, i.e. the resources to achieve one's objectives. Our objective was to highlight that only competence can justify social hierarchy. We conducted eight studies, which confirmed our hypothesis. Thus, the more people justify inequalities, the more they attribute competence to people with a high status in society (i.e. rich, powerful people). Moreover, the relationship between assertiveness and status has not been moderated by the justification of the system, suggesting that assertiveness does not justify status differences

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Montaudié, Henri. "CLEC12B un gène de la famille des lectines impliqué dans le processus de melanomagénèse en agissant comme un gène suppresseur de tumeurs : CLEC12B un gène suppresseur de tumeurs impliqué dans le mélanome." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR6013.

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Malgré les progrès thérapeutiques importants accomplis ces dernières années, le mélanome garde un pronostic péjoratif au stade métastatique. Il est donc essentiel d’explorer les mécanismes moléculaires et cellulaires impliqués dans le processus de mélanomagénèse dans la perspective de découvrir de nouvelles cibles thérapeutiques.Une analyse transcriptomique comparative de la peau de patients atteints de vitiligo (et donc dénuée de mélanocytes) par rapport à de la peau non lésionnelle et la peau de sujets témoins, nous a permis de découvrir que le récepteur de la lectine C, CLEC12B (C-type lectin domain family 12-member B) était sélectivement et fortement exprimé par les mélanocytes. L'objectif de cette étude était d'étudier le rôle de CLEC12B in vitro et in vivo dans le mélanome. Nous avons d’abord montré que l’expression des transcrits de CLEC12B, par technique RT-PCR, était plus faible dans les lignées cellulaires de mélanome et dans les cellules de mélanome extraites de métastases de patients que dans les mélanocytes humains normaux. D’autre part, l'analyse protéique par immunohistochimie a montré une expression plus faible de CLEC12B, dans des échantillons de mélanome humain (mélanomes primaires et métastatiques de patients) par rapport aux nævi. La base de données TCGA, a révélé que les patients avec une expression élevée de CLEC12B avaient une survie médiane significativement supérieure à ceux avec une expression faible. Ces premiers résultats suggèrent un rôle potentiel de CLEC12B dans le processus de mélanomagénèse. Dans un second temps, en utilisant une construction de lentivirus, nous avons surexprimé (Ov-CLEC12B) et régulé négativement (Sh-CLEC12B) CLEC12B dans deux lignées cellulaires de mélanome humain (A375 BRAF muté et MeWo BRAF sauvage). Ainsi nous avons démontré que Ov-CLEC12B inhibait la prolifération et la formation de colonies, par l’activation de p53/p21/p27 et l’inhibition des STATs et notamment STAT3 qui est constitutivement activé dans le mélanome. Par ailleurs, par une expérience de co-immunoprécipitation et après avoir généré un mutant de CLEC12B sur son domaine ITIM, nous avons montré que CLEC12B par son domaine ITIM, recrute et active directement la tyrosine phosphatase SHP-2. Une fois activée par CLEC12B, SHP-2 inactive la voie STAT (diminution des formes phosphorylées de STAT1, 3 et 5) et augmente l’expression de p53/p21/p27 entrainant un ralentissement du cycle cellulaire en phase G0-G1. Des effets opposés sont observés après l’extinction de CLEC12B. Enfin, les propriétés tumorigèniques de CLEC12B ont été étudiées chez des souris nude avec des expériences de xénogreffe de tumeur (injection de la lignée A375 Ov et Sh-CLEC12B). En accord avec les résultats in vitro, la croissance tumorale dans le groupe Ov-CLEC12B était significativement réduite par rapport au groupe véhicule et était associée à une diminution de l'expression de pSTAT3 et à une augmentation de p53 dans les tumeurs. Le contraire a été observé dans les conditions Sh-CLEC12B.Au total, ce travail révèle que CLEC12B est un nouveau gène suppresseur du mélanome qui agit en régulant le cycle cellulaire et en réprimant l'activation de STAT
Despite significant progress in recent years, melanoma remains among the most aggressive and deadly human cancers. Thus, it still remains essential to explore the molecular and cellular mechanisms involved in the melanomagenesis process in order to discover new therapeutic options. A transcriptomic analysis from vitiligo patient skins allowed us to discover that the C-lectin receptor CLEC12B (C-type lectin domain family 12-member B) is selectively and strongly expressed by melanocytes. The objective of this study was to investigate the role of CLEC12B in melanoma. We first showed that the expression of CLEC12B is lower in melanoma cell lines, and in melanoma cells extracted from patient metastases, compared to the expression in normal human melanocytes. Immunohistochemical analysis further showed a lower expression of CLEC12B, in human melanoma samples (primary and metastatic melanomas from patients) compared to melanocytic nevi. Using the TCGA database, we found that patients with high CLEC12B expression have a significantly higher median survival than those with low expression. Taken together, these first results suggested a potential role of CLEC12B in melanomagenesis process. Subsequently, using a lentivirus construct, we overexpressed (Ov-CLEC12B) and downregulated (Sh-CLEC12B) CLEC12B in human melanoma cells lines, and we demonstrated that CLEC12B inhibits the proliferation and colony formation, through activation of p53/p21/p27 and the inhibition of STAT pathway. We demonstrated, using a co-immunoprecipitation assay, and after generating a mutant of CLEC12B ITIM domain, that CLEC12B function is mediated by its ITM domain, which directly recruits and activates the tyrosine phosphatase SHP-2. Once activated by CLEC12B, SHP-2 inactivates the STAT pathway, as observed with a decrease of STAT1, STAT3 and STAT5 phosphorylated forms and promotes p53/p21/p27 pathway activation with a slow down in G0-G1 phase of cell cycle. Opposite effects were observed after silencing CLEC12B. Finally, tumorigenic properties of CLEC12B were analyzed in nude mice with tumor xenograft experiments. In accordance with in vitro results, the tumor growth in Ov CLEC12B group was significantly decreased compared to vehicle group and was associated with a decreased expression of pSTAT3 and an increase of p53 within the tumors. The opposite was noted with Sh CLEC12B. This study reveals CLEC12B as a novel potent suppressor gene in melanoma by regulating cell cycle and repressing STAT activation

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Cain, Steven Robert. "The Standing of the Soul: The Search for a Middle Being between God and Matter in the De Statu Animae of Claudianus Mamertus." Thesis, Boston College, 2016. http://hdl.handle.net/2345/bc-ir:105066.

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Thesis advisor: Stephen Brown
This thesis is intended as a complement to Fr. Ernest Fortin’s Christianisme et culture philosophique. In that work, he examined the De statu animae of Claudianus Mamertus and its affinity to the thought of the Neoplatonic philosophers (especially Porphyry) in order to make its doctrine more clear. But he also looked at it to see the greatness of philosophical spirit that its author possessed, a remarkable spirit considering the time in which he wrote. Though Fr. Fortin’s work is quite thorough, there are some aspects of the De statu animae that are treated only slightly or not at all. This thesis aims at filling out some of them. The thesis first considers the difficulty of the philosophical question discussed in the work: the incorporeality of the human soul. Among the many difficulties which this question raises is one raised by Faustus of Riez, against whom Claudianus is writing, namely, that of conceiving an incorporeal creature without confounding it with God. It then considers the historical context, both political and philosophical, in which Claudianus lived and wrote. In particular, it brings out the influence of the Emperor Julian in his efforts to replace Christianity with pagan philosophy (especially as influenced by Porphyry and Iamblichus), and his connection with the intellectual life in Gaul. This it does to put into relief the magnanimity of a Christian writer who could look to the philosophy that most influenced the most ardent opponents of Christianity and see in it an ally rather than an enemy. Faustus regarded the philosophers as enemies because he thought them, in their reasonings, to have raised the soul to the dignity of its Creator. Of the philosophers open to this charge of impiety, it is, perhaps, most aptly laid upon the Platonists. A tendency in this direction appears in Plato, and reaches something of an apex in the thought of Plotinus. In Plato’s writings, it appears especially in the Phaedo, which Claudinaus quotes at length in the Second Book. The thesis looks at this dialogue to bring into relief this tendency in the work, and then compares it to Ennead V.1 to show that Plotinus takes the considerations in that dialogue and follows them out to show the kinship between the soul and the divine. Against this background, there are a couple of aspects of De statu animae that emerge. The first is the importance of seeing the soul as a middle being between God and bodily creatures. The second is the importance of seeing the soul as the imago Dei. Claudianus, in spite of his rhetoric, saw the seriousness of the difficulty raised by Faustus, and his work can be read, especially in the First Book, as an attempt to raise the mind of the reader from the fleshy world of sensation to the more beautiful, true, and good world of the spirit. The thesis argues that though the work is polemical, and so formed somewhat in the order of Faustus’s own arguments, Claudianus has worked that order to his own end; this can be seen in his use of the word status. This word is taken from Faustus, who uses it in his letter to name the nature of the soul. Claudianus, without leaving behind that sense, uses it to bring out the importance of understanding the soul’s nature through understanding its standing in the order of beings. His arguments are meant to help the reader to do just that. He first establishes that the world would be more perfect if there were an incorporeal creature, then he argues that there is in fact such a creature, and finally how it is possible for there to be such a creature. In doing so, he relies on ideas of the Neoplatonists, and especially Iamblichus, who looked at the soul as a middle being in order to see it as, one the one hand, less than the beings of the intelligible order, and yet superior to those of the sensible order. It is in this notion of the soul as a middle being that Claudianus finds an account for the changeableness of the soul without relying on matter. To show this, he invokes a distinction among motions: stable, in time, and in time and place. The first belongs to God, the second to the soul, and the last to bodies. This distinction arises from the fact that God is above all the categories of Aristotle, bodies are subject to them all, but the soul is subject only to some. In this way, the soul can be seen to undergo qualitative change, or changes in its affections, without suffering change in place. Thus, though not a body, it is nevertheless subject to change of some sort. And so, though superior to bodies, it falls short of the perfection of its Creator. But running throughout this discussion is the notion of image. And at the end of the book, its importance emerges. When Claudianus turns to a consideration of our act of knowing, the nature of the soul becomes more clear. When the soul turns its attention from bodies to look at itself, what it sees is an image of God, Who is incorporeal. And so, it sees, if it can free itself from the seductions of the images of bodies it has drawn in through the senses, that it is incorporeal. Here he reveals to the reader more fully what he has been trying to do. He has been working to turn the eye of the mind from the world of sensation to look at itself in itself, for if it does this, it will see itself as the imago Dei, and thus incorporeal. In this last aspect of the work especially, we can see the influence of Iamblichus, who, as Carlos Steel has shown, came to conceive of the soul as the image of Intellect precisely to establish it as a middle being between Intellect and the material world. It is an image so that it can be both like and unlike its exemplar. It understands (or more precisely, reasons) and so is like Intellect. But it does so by introducing order into its thoughts so that though always thinking (like Intellect), it moves from one thought to the next. Thus, it introduces time into the world. In this way, it departs from Intellect and becomes subject to change, though not in place. Claudianus recognizes in this a way of conceiving of the soul as incorporeal, therefore like God, and yet subject to change in time, therefore unlike Him, and so a creature. And so he comes to see the soul, in its essence to be the image of its Creator. Claudianus, in his refutation of Faustus, has raised the minds of his readers to lofty heights. Following the teachings of the Platonists, to whom his friend Sidonius likens him in everything except his garb, he has purged his mind from the entrapments of the corporeal world, has raised it to the pure world of being, and found himself a part of it. But those he has followed had been, either directly or indirectly, ardent foes of the faith which he professed and to which he had given his life. Porphyry had composed a work attacking Christianity; and Iamblichus, through his disciples, had inspired Julian with a devotion to the pagan gods that led him to attack the Church both in his writings and in his political endeavors. But unlike Faustus and others like him, he saw a harmony between his faith and his philosophy that gave him confidence that the natural light of reason and the light of revelation could work together to unite his soul to its Beginning, which is also his End
Thesis (PhD) — Boston College, 2016
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Philosophy

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Ogliari, G. "THE MILAN GERIATRICS 75+ COHORT STUDY: UNRAVELLING THE DETERMINANTS OF HEALTHY AGEING AND LONGEVITY." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/372759.

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Current evidence on older adults is derived from population-based cohort studies and randomized controlled trials, which may not include frail individuals. Data are lacking on older outpatients, a potentially diverse population. Therefore, we initiated the Milan Geriatrics 75+ Cohort Study, a prospective hospital-based outpatient cohort study. Chapter 1 of this thesis provides a background on the controversies regarding the homeostasis of older adults. Chapter 2, 3 and 4 report findings from the Milan Geriatrics 75+ Cohort Study. Chapter 2 explores the association between blood pressure and cognition, and whether it varies according to age and functional status. Chapter 3 examines the relationship between blood pressure and mortality risk, and whether it varies according to functional and cognitive status. Chapter 4 investigates the association between thyroid status and mortality risk in euthyroid older adults, and whether it differs by sex and age. Chapter 5 and 6 report findings from the PROSPER cohort, which includes older adults at high cardiovascular risk. Chapter 5 presents new evidence on the association of heart rate and heart rate variability with functional decline. Chapter 6 analyses the relationship between blood pressure variability and functional decline. Chapter 7 summarises and discusses the main findings of this thesis.

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KIES, FATIMA. "Contribution to the study of the ecological status of the West Algerian coastal waters within the Water Framework Directive (WFD)." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/207337.

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Le aree costiere sono sottoposte a pressioni antropogeniche e ai cambiamenti climatici. Negli ultimi venti anni, il concetto di gestione integrata della zona costiera ben presente nelle diverse azioni politiche, manca degli strumenti a supporto degli sforzi di pianificazione e gestione, specialmente nelle aree di estuario dove gli effetti dei bacini fluviali sulle zone costiere sono poco evidenziati nella maggior parte delle implementazioni. Gli ambienti costieri costituiscono un ambiente dinamico influenzato da input continentali sia naturali che antropogenici e controllato da fattori idrodinamici e climatici. Alcune zone costiere sono, con la loro geografia e geomorfologia, un recettore in cui sono presenti corpi idrici carichi di minerali esogeni e / o di materia organica derivanti dall'attività antropica. Il tempo di permanenza di questi corpi idrici è legato all'intensità delle correnti marine che controlla la distribuzione e la diluizione delle sostanze disciolte che possono influenzare l'ecosistema. Al fine di valutare lo stato trofico delle acque marine costiere del Mediterraneo, la Direttiva Quadro sulle Acque (DQA) richiedeva il monitoraggio della concentrazione di Clorofilla-a (Simboura et al., 2005) e l'indice trofico TRIX proposto da Vollenweider et al. (1998), che tiene conto delle sostanze nutritive complessive, della clorofilla e dell'ossigeno disciolto nell'ambiente. I nostri risultati hanno fornito la classificazione dello stato di qualità ecologica (EQS) dei tre siti Sonactere, Cheliff e Sokhra rispettivamente come stato Scadente, in base alla concentrazione di clorofilla, e come Cattivo, secondo l'indice trofico (TRIX). Le acque costiere di Mostaganem nell'Algeria occidentale mostrano una situazione di grave eutrofizzazione. Tuttavia, per capire meglio lo stato dell'ecosistema, è essenziale esplorare l'intera area costiera di Mostaganem per un lungo periodo. Gli indici Chl-a e TRIX sono stati sviluppati per le regioni del Mediterraneo, ma dovrebbero essere adattati alle condizioni locali in modo che siano pertinenti e più affidabili e rappresentativi, dato l'aspetto eterogeneo delle zone costiere del Mediterraneo.
Coastal areas are under anthropogenic and climate change pressures. During the last twenty years, the concept of Integrated Coastal Zone Management, as provides the overall policy frames, but tools supporting the planning and management efforts are almost lacking, especially in the estuary areas where the effects of river basins on coastal zones are nearly absent in most implementations. Coastal environments constitute a dynamic environment influenced by both natural and anthropogenic continental inputs and controlled by hydrodynamic and climatic factors. Some coastal zones are, by their geography and geomorphology, a receptor where are trapped water bodies loaded with exogenous mineral and /or organic matter resulting from the anthropic activity. The residence time of these water bodies is related to the sea currents intensity which controls the distribution and dilution of dissolved substances that can unbalance the ecosystem. In order to assess the trophic status of coastal Mediterranean marine waters, the Water Framework Directive (WFD) required the monitoring of the Chlorophyll-a concentration (Simboura et al., 2005) and the trophic index TRIX proposed by Vollenweider et al. (1998), which takes into account the overall nutrients, chlorophyll-a, and dissolved oxygen in the environment. Our results highlighted the ranking of the ecological quality status (EQS) of the three sites Sonactere, Cheliff, and Sokhra as bad according to the Chlorophyll concentration and as Poor status according to trophic index (TRIX). The coastal waters of Mostaganem in western Algeria have proved to be in a situation of severe eutrophication. However, to better understand the state of the ecosystem, it is essential to explore the entire coastal area of Mostaganem over a long period. The Chl-a and TRIX index were developed for Mediterranean regions but it should be adapted to local conditions so that it is relevant and more reliable and representative, given the heterogeneous aspect of the Mediterranean coastal zones.

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Lundberg, Johanna. "Social status : a state of mind?" Doctoral thesis, Linköpings universitet, Hälsouniversitetet, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15552.

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This thesis is concerned with social stratification of psychosocial factors and social position measurement in population samples collected in mid-Sweden 2000-2006. Traditional resource-based measures of social position (occupation, education) and so far less explored prestige-based measures (subjective status, status incongruence) are tested with respect to their associations with psychosocial factors, emotions, and selfrated health. Three papers in this thesis are based on data from the Life Conditions, Stress, and Health (LSH) study, using a randomly selected population sample. Data for the fourth paper is a regional sample drawn from the health-related survey “Liv och Hälsa 2000”. Statistical methods range from correlation analysis to logistic regression and repeated measures analyses. Results from studies I and IV show that psychosocial factors are unequally distributed within the population in a linear manner, so that the lower the socioeconomic position (SEP), the more unfavourable levels. This is independent of whether we study this in a highly unequal setting such as Russia, or in a more egalitarian society such as Sweden. The stability of psychometric instruments over two years tend to be lower for all instruments among low SEP groups, and differ significantly for self-esteem and perceived control among groups with high and low education, and for cynicism among groups with high and low occupational status. Results from studies II and III point to the relevance of individuals’ own thoughts about themselves, and the potential impact on the self by normative judgements of social position in a certain hierarchical setting. In paper II, the prestige-based measure of subjective status was influenced by resource-based measures, such as self-rated economy and education, but also by life satisfaction and psychosocial factors. The importance of self-evaluation was especially obvious from the study on status incongruence (study III) where the traditionally protective effecs of a high education seem to disappear when combined with a lowstatus occupation. Shaming experiences may play an important role here for our understanding of self-perception.

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Tai, Daven C. H. "STAT6 and STAT4 in murine atherosclerosis." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45653.

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Atherosclerosis is a chronic inflammatory condition and the major underlying cause of heart attacks and strokes. Since the immune system is paramount in all stages of atherosclerosis, modulating the immune response is an attractive therapeutic strategy for atherosclerotic disease. Signal transducers and activators of transcription (STAT) 6 and STAT4 are essential orchestrators of the anti-inflammatory Th2 response and the pro-inflammatory Th1 response, respectively. Using bone marrow transplantation to deplete STAT6 and STAT4 expression in specific immune compartments in low density lipoprotein receptor knockout (Ldlr-/-) mice, we investigated the validity of modulating the immune response through STAT6 and STAT4 as a prospective treatment strategy for atherosclerosis. We found that myeloid-specific STAT6 depletion did not significantly impact atherosclerotic lesion area or stability in Ldlr-/- mice fed an atherogenic diet for 8 or 14 weeks. In addition, hematopoiesis in the myeloid and lymphoid lineages was not significantly affected by the absence of myeloid STAT6. In contrast, total hematopoietic system STAT4 depletion profoundly exacerbated atherosclerotic lesion area and vulnerability in Ldlr-/- mice following 8 weeks of atherogenic diet. Hematopoietic perturbations in mice transplanted with STAT4-deficient bone marrow are highly reminiscent of interferon (IFN)-gamma-dependent effects on immune cell development in interleukin-12-treated mice, suggesting that IFN-gamma levels may be elevated in response to hypercholesterolemia in the absence of STAT4. Myeloid-specific STAT4-deficient mice also developed larger atherosclerotic lesions in the aortic root, providing evidence that even partial STAT4 insufficiency can potentially accelerate atherosclerosis. This thesis provides novel insights into the functions of STAT6 and STAT4 in atherosclerosis.

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Ayoub, Marie-Louise. "Facteurs influençant les valeurs du TBS chez des jeunes adultes sains et des femmes ménopausées avec ou sans antécédents de fractures ostéoporiques." Thesis, Littoral, 2016. http://www.theses.fr/2016DUNK0429/document.

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Les buts de cette thèse étaient de définit les déterminants du TBS chez les jeunes adultes et les femmes ménopausées, et de vérifier si le TBS était associé aux fractures ostéoporiques chez les femmes ménopausées et les femmes ménopausées obèses. L'étude 1a a été menée sur 26 jeunes femmes et montre que la consommation maximale d'oxygène et le niveau de puissance musculaire des membres inférieurs sont positivement corrélés au TBS ( valeurs de "r" comprises entre 0.37 et 0.63). L'étude 1b a été menée sur 56 jeunes femmes dont 14 en surchage pondérale ; elle suggère que le fait d'être en surcharge pondérale n'est pas associé à des valeurs de TBS plus élevées. Le seul déterminant positif du TBS dans l'étude 1b était dans la VO₂ max. L'étude 1c a été menée sur 67 jeunes hommes dont 32 en surpoids et 12 obèses ; elle suggère que l'obésité et le surpoids n'influencent pas positivement les valeurs de TBS. L'étude 1c montre que le poids et le pourcentage de masse grasse sont négativement corrélés au TBS ( r= -0.28 et r = -0.38 respectivement). L'étude 2a a été menée sur 1000 femmes ménopausées dont 164 ayant des fractures ostéoporotiques prévalentes ; elle suggère que le TBS est associé avec la présence des franctures ostéoporotiques prévalentes. L'étude 2a suggère que chez les femmes ménopausées, des corrélations positives existent entre la DMO du rachis lombaire et le TBS, et des corrélations négatives existent entre l'âge et le TBS. L'étude 2b a été menée chez 300 femmes ménopausées obèses dont 40 ayant des fractures ostéoporotiques prévalentes ; elle suggère que le TBS n'est pas associé avec la présence des fractures ostéoporotiques prévalentes dans cette population contrairement à la DMO du rachis lombaire qui était associée avec la présence de ces fractures. L'étude 2b suggère donc que le TBS n'est pas un déterminant indépendant des fractures ostéoporotiques prévalentes chez les femmes ménopausées adultes
The aims of this thesis were to define the determinants of TBS in young adults and postmenopausal women and to verify whether TBS is associated with osteoporotic fractures in postmenopausal women and in obese postmenopausal women. Study 1a included 26 young women and showed that maximal oxygen consumption and muscular power level of the lower limbs are positively correlated to TBS (r values between 0.37 and 0.63). Study 1b included 56 young women 14 of which were overweight ; this study suggests that being overweight is not associated with higher TBS values. The only positive determinant of TBS in study 1b was VO₂ max. Study 1c included 67 young men 32 of which were overweight, and 12 were obese ; this study suggests that obesity and overweight do not positively influence TBS values. Study 1c shows that body weight and fat mass percentage are negatively correlated to TBS (r = -0.28 and r = -0.38 respectively). Study 2a included 1000 postmenopausal women 164 of which have presented a previous osteoporic fracture ; this study suggests that TBS is associated with previous osteoporotic fractures. Study 2 a suggests that in postmenopausal women, lumbar spine BMD is positively correlated to TBS while age is negatively correlated to TBS. Study 2b included 300 obese postmenopausal women 40 of which have presented a previous osteoporotic fracture ; this study suggests that TBS is not associated with previous osteoporotic fractures in this population contrary to lumbar spine BMD which is associated with previous osteoporotic fractures. Study 2b suggests therefore that TBS is not independant determinant of osteoporotic fractures in obese postmenopausal women

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Shivakumar, Vasanth. "Regulation of STAT6, STAT3 and STAT1 by the Cytoplasmic Tail of Polycystin-1, the Protein Affected in Polycystic Kidney Disease." Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1176482324.

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Dicataldo, Raffaele. "The role of environmental factors on linguistic and cognitive development in preschool children." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3424721.

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The studies reported in this thesis, are inserted in the research line aimed to investigate the influence that some environmental factors - Socioeconomic Status, Bilingual exposure, and literacy environment - have on cognitive and linguistic development in pre-school age. The rationale of these studies is that, although the role of environmental factors on children development as well as the long-term effects of early interventions are well established, still, there is a conspicuous percentage of children that begin their formal schooling process unprepared to handle the demands of the school learning processes. The first Chapter provides an overview of theoretical background and previous literature concerning the effects that several environmental factors have on the cognitive and linguistic development of preschoolers. In Chapter 2, results of a study aimed to investigate the specific and unique effect of SES and Bilingual exposure on a large set of cognitive and linguistic abilities, are reported. Findings provide new evidence that the two environmental factors examined contribute uniquely to language and cognitive development, irrespective of the other factor. In Chapter 3, results of a study aimed to examine the contribution of receptive vocabulary in narrative comprehension of sequential bilingual children are reported. Findings suggest that a low vocabulary does not prevent children to comprehend adequately a narrative text, highlighting the involvement in narrative comprehension, of other higher-order skills. In Chapter 4, are reported results of a study in which, starting from evidence of the previous study, we analyzed structural relations among a large and comprehensive set of linguistic and cognitive abilities and narrative comprehension, within the framework of “multicomponent model of comprehension”. In Chapter 5 are reported results of a study aimed to analyze the efficacy of a classroom-based shared book reading direct intervention aimed to foster broad oral language abilities in preschoolers coming from low-SES families. In Chapter 6 are reported results of a study aimed to analyze of a Parent Training on dialogic book reading aimed to foster broad oral language skills of pre-school children. Eventually, in Chapter 7, a general discussion highlights the main findings presented in this thesis, by considering them collectively, and by raising future proposals and questions about the topics debated in these Chapters.
Gli studi riportati in questa tesi, sono inseriti nella linea di ricerca volta ad indagare l'influenza che alcuni fattori ambientali - Status socioeconomico, esposizione bilingue e ambiente di alfabetizzazione - hanno sullo sviluppo cognitivo e linguistico in età prescolare. La ratio di questi studi è che, sebbene il ruolo dei fattori ambientali sullo sviluppo dei bambini e gli effetti a lungo termine degli interventi precoci siano ben definiti, c'è ancora una cospicua percentuale di bambini che iniziano il loro iter scolastico formale non preparati a gestire le richieste dei processi di apprendimento scolastico. Il primo capitolo fornisce una panoramica del background teorico e della letteratura riguardante gli effetti che diversi fattori ambientali hanno sullo sviluppo cognitivo e linguistico dei bambini in età prescolare. Nel capitolo 2 sono riportati i risultati di uno studio volto ad indagare l'effetto specifico e unico dell'esposizione bilingue e del SES su un ampio insieme di abilità cognitive e linguistiche. I risultati indicano che i due fattori ambientali esaminati contribuiscono in modo univoco allo sviluppo linguistico e cognitivo, indipendentemente dall'altro fattore. Nel Capitolo 3 sono riportati i risultati di uno studio volto ad esaminare il contributo del vocabolario recettivo nella comprensione narrativa di bambini bilingue sequenziali. I risultati suggeriscono che un basso vocabolario non impedisce una adeguata comprensione del testo narrativo, evidenziando il coinvolgimento, di altre abilità di ordine superiore. Nel capitolo 4 sono riportati i risultati di uno studio in cui, partendo dall'evidenza dello studio precedente, abbiamo analizzato le relazioni strutturali tra un ampio e completo insieme di capacità linguistiche e cognitive e la comprensione narrativa, nell'ambito del "modello multicomponente della comprensione". Nel capitolo 5 sono riportati i risultati di uno studio volto ad analizzare l'efficacia di un intervento diretto di lettura condivisa di libri condivisi per favorire l'acquisizione di ampie capacità di linguaggio orale nei bambini in età prescolare provenienti da famiglie a basso SES. Nel Capitolo 6 sono riportati i risultati di uno studio finalizzato all'analisi dell'efficacia di un parent-training sulla lettura dialogica, volto a favorire lo sviluppo di abilità del linguaggio orale nei bambini in età prescolare. Infine, nel capitolo 7, la discussione generale mette in evidenza i principali risultati presentati in questa tesi, considerandoli collettivamente e sollevando proposte e domande future sugli argomenti discussi in questi capitoli.

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Pau, Michael. "Leukämische Fusionsproteine mit Tyrosinkinase-Aktivität induzieren eine konstitutive Aktivierung von STAT1, STAT3 und STAT5 und verursachen eine maligne Transformation von hämatopoetischen Vorläuferzellen." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-27095.

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Mitrache, Marius-Mircea. "L'enjeu de l'Europe Centrale-Orientale pour la diplomatie française sous François Mitterand, dans le contexte de la question allemande." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST0096.

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François Mitterrand aimait l'Histoire, et décidemment l'Histoire avait aimé Mitterrand, car peut-être ce n'est pas par hasard que c'était lui le gouverneur du destin de la France au moment d'un si grand tournant dans l'histoire européenne. Si l'historien allemand Tilo Schabert le nommait « le président-philosophe », alors quelle a été sa réponse devant le Sphynx de l'Histoire, en 1989 ? Pour ou contre la réunification de l'Allemagne ? A vrai dire, le statu quo de la Guerre froide et l'existence des deux Allemagne au cœur de l'Europe, convenaient à merveille à la France. L'écrivain François Mauriac disait : « J'aime l'Allemagne tellement, que je désire en avoir deux ». Une Allemagne divisée a permis à la France de prendre le leadership ouest-européen. Avec une participation active dans la construction européenne, une relation privilégie avec Moscou, sa popularité parmi les capitales est-européennes, et son indépendance dans le cadre de l'Otan, la France semblait avoir tous les atouts pour être la première puissance de l'Europe Occidentale. Pour comprendre la diplomatie de Mitterrand, celle-ci doit être vue dans la perspective d'un monde en changement, d'un statu quo en cours de modification : son tour dans les capitales de l'Est, le projet pour le traité de Maastricht (avec son enjeu historique – l'adoption d'une monnaie unique), la ratification des traités consentant à la réunification de l'Allemagne, le soutien envers Gorbatchev et finalement son projet pour une grande confédération pan-européenne sur le moule de la Conférence sur la Sécurité et Coopération en Europe, évoquant l'ambition de Charles de Gaulle de construire l'Europe de l'Atlantique à l'Oural. Dans ce labyrinthe d'événements il y a un fil d'Ariane, un raisonnement clair et un peu trop visionnaire de la part de Mitterrand. C'est la qualité (et en même temps le défaut) de résoudre le présent en pensant l'avenir. Ceux qui comprennent tout avant les autres seront toujours incompris par la majorité. Mitterrand savait que l'Allemagne était un pays à risques, surtout pour l'hégémonie française et ensuite pour la construction européenne, le grand projet de construction européenne entamé depuis 1945. C'est le but de notre recherche de montrer la source et la forme des manifestations de la politique étrangère de Mitterrand envers l'Europe Centrale-Orientale. La diplomatie de François Mitterrand envers l'Europe Centrale-Orientale, qui redeviendra une carte mentale géographique suite à la question de la réunification allemande, se trouve au carrefour, à la croisée de l'approche gaulliste, réaliste, et de celle poursuivie par Pompidou et Giscard d'Estaing, l'approche constructiviste. Seulement à travers la grille d'une analyse réaliste-constructiviste on peut comprendre les ressorts et les jalons de sa politique étrangère concernant la réunification allemande, la construction européenne (le congrès de Strasbourg de 1989) et finalement l'Europe Centrale-Orientale sortie du communisme et l'Union soviétique (le projet de confédération pan-européenne sera présenté le 31 décembre 1989). Le fil d'Ariane que nous avons évoqué au début est une tresse faite par l'entrelacement des deux fils différents, celui du réalisme et celui du constructivisme. Par cette voie on peut comprendre de la part de Mitterrand, le désir l'accéler l'intégration de la Communauté européenne, la nécessité de trouver un encadrement pour la réunification pacifique de l'Allemagne, et puis faire son ancrage dans les valeurs occidentales, d'éviter la désintégration d'une Europe Centrale-Orientale
François Mitterrand loved history, and history definitely loved Mitterrand, and because of this maybe it is not by chance that he governed the destinies of France at a great turning point in European history. If the German historian Tilo Schabert called him ”le président-philoshophe”, then one might ask what has been the response in front of the Sphynx of History in 1989. Was he for or against the reunification of Germany? Indeed, the status quo of the Cold War and the existence of two Germanys in the heart of Europe suited perfectly for France. The writer François Mauriac famously once said:”I love Germany so much that I want to have two.” A divided Germany has enabled France to consolidate the leadership of West European. With active participation in European integration, a special relationship with Moscow, with its popularity among the Eastern European capitals, and its independence in NATO, France seemed to have everything it takes to be the first power of the Western Europe. To understand it, the diplomacy of Mitterrand must be seen in the context of a changing world, where the status quo was challenged. Starting from this premises we can understand his diplomatic tour in the capitals of the East, the project for the Maastricht Treaty ( with its historic stake - the adoption of a single currency), the ratification of 2+4 treaty consenting to the reunification of Germany, his support for Gorbachev and finally his project for a major pan- European confederation on the mold of the Conference on Security and Cooperation in Europe , echoing the ambition of Charles de Gaulle to build a Europe from the Atlantic to the Urals. In this maze of events the common thread was Mitterrand's a clear insight of the consequences the will follow the reunification. Those who understand everything before others will always be misunderstood by the majority. Mitterrand knew that Germany was a country at risk, especially for the French hegemony and then to European construction, the great European project started since 1945. It is the goal of our research to show the source and the form of Mitterrand's foreign policy toward East Central Europe in the context of the German question, towards a region that once again will become for France a geographic mental map. Mitterrand's diplomatic approach finds itself at a crossroads between a Gaullist approach, a realist one, and the one pursued by Pompidou and Giscard d'Estaing, a constructivist approach. Only through the grid of a realistic - constructivist analysis one can decipher the milestones of its foreign policy regarding the German reunification (2 +4 Treaty in September 1990), the European integration (the stake European Council in Strasbourg in1989) and finally East-Central Europe's post-communist architecture (through project of the pan European confederation he unveiled on 31 December 1989). Only in this way we can understand Mitterrand's desire to accelerate the integration of the European community, the need to find a framework for the peaceful reunification of Germany by anchoring it its Western commitments, and at the same time avoiding the disintegration of East-Central Europe

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Wang, Kepeng. "The involvement of JAK2/STAT2/STAT3 in myogenic differentiation /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BICH%202008%20WANGK.

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PORCU, MICHELE. "Cerebral white matter status and resting state functional MRI." Doctoral thesis, Università degli Studi di Cagliari, 2022. http://hdl.handle.net/11584/327393.

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White Matter (WM) is a pivotal component of the Central Nervous System (CNS), and its main role is the transmission of the neural impulses within the CNS and between CNS and Peripheral Nervous System (PNS). It is note from literature that changes in the WM affects the function of the CNS with effects on the higher neurological function, included cognition. Further, it has been theorized in the last decades that ageing-associated decline in higher neurological functions, in particular in the neurocognitive sphere, could be at least partly explained by the “disconnection” of the cortical areas of the brain due to the WM degeneration. Although standard “in-vivo” imaging biomarkers of WM integrity have not been validated yet for clinical purposes, several researches have demonstrated the correlation between different potential imaging biomarkers and WM integrity. The aim of the PhD project is to explore and better understanding the effects of WM status on the brain structure, networking and cognition. In particular, we designed three distinct explorative and cross-sectional studies; more specifically, we analyzed the effects of two Magnetic Resonance Imaging (MRI) markers of WM degeneration (the global Fractional Anisotropy (gFA) and the white matter hyperintensities burden (WMHb), respectively) on the brain activity measured with the Resting-State Functional Magnetic Resonance Imaging (rs-fMRI) technique. The project was conducted by analyzing a human population of healthy subjects extracted from the public available dataset “Leipzig Study for Mind-Body-Emotion Interactions” (LEMON). The results of these studies have been published during the PhD course on three distinct international scientific papers.

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Lalonde, Gloria Marjorie Lucy. "National development and the changing status of women in India : a state by state analysis." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66067.

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Durant, Lydia. "The roles of STAT3 and STAT5 in intestinal immune regulation." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534166.

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26

Schroeder, Jacquelyn Ann. "NGO-State Relations: Freedom House Status and Cooperation Versus Conflict." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1358101658.

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Johnson, Patricia Ann. "The status of freshwater compensatory wetland migration in Washington State." Online pdf file accessible through the World Wide Web, 2004. http://archives.evergreen.edu/masterstheses/Accession86-10MES/Johnson_PAMESThesis2004.pdf.

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Gunes, Serife Basak. "Essays on experimental economics: preference Reserval and networks." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7402.

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Esta tesis utiliza un enfoque experimental para comprender las interacciones dentro de redes y percibir las decisiones causando inversión de preferencia (IP). El Capítulo 1 experimentalmente introduce comunicaciones no vinculantes a un modelo de producción de un bien costoso, que es no excluible entre personas vinculadas en una red. Los resultados muestran que la comunicación de dirección única no mejora coordinación tanto como la comunicación entre conjuntos máximos independientes. El Capítulo 2 analiza experimentalmente un modelo de conflictos bilaterales integrado en redes, donde los oponentes invierten para ganar recursos. Concluye sobre exceso de inversiones comparado a las predicciones de equilibrio. Por último, el Capítulo 3 mira si el efecto dotación inicial resultado de statu quo conduce IP. Esto es analizado por la interrogación de la buena voluntad de cambiar una lotería dotada para otra o pago seguro. En contrario de las predicciones, resultados demuestra que dotaciones son renunciadas con frecuencia.
This thesis uses an experimental approach in understanding group decisions and interactions in networks and perceiving individual decisions causing preference reversal. Chapter 1 experimentally introduces different communication schemes to a production model of a costly good that is non-excludable among individuals linked within a network. Results show that one-way communication is not as efficient as in earlier literature; yet communication among maximal independent sets enhances coordination. Chapter 2 experimentally analyzes a model of multiple bilateral conflicts embedded in networks where opponents invest in conflict technology to win resources. It concludes on tendency to invest in excess of equilibrium predictions. Finally, Chapter 3 looks at whether preference reversal is driven by an endowment effect explanation originating from status quo bias. This is analyzed through questioning individuals' willingness to exchange their endowed lottery for another lottery or sure money. Contrary to the predictions, results show that individuals most often disclaim their endowments.

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Cook, Justin. "Faire la paix par la reconnaissance : l’étude de cas de la transformation des relations moldo-pridnestroviennes de 1989 à 1998." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL20013/document.

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Le conflit civil moldave entre 1989 et 1992 a laissé un pays et une population divisés entre le fleuve Dniestr/Nistru. Malgré la victoire de la Pridnestrovie (RMP) dans sa guerre d’indépendance, elle n’a pas atteint son objectif de devenir un Etat reconnu. L’Accord de cessez-le-feu de 1992 qui a mis officiellement fin à la guerre a renforcé la séparation de la RMP par la création d’une zone tampon et l’établissement des forces de maintien de la paix. Comme convenu dans cet accord, la fin du nouveau statu quo et donc la résolution finale du conflit devraient passer obligatoirement par la détermination d’un nouveau statut politique pour la RMP. Faute d’avoir réussi à déterminer un statut officiel, le conflit est resté gelé. Lors de la période d’après-guerre, l’équilibre des pouvoirs a favorisé la RMP sur le plan économique, énergétique et sécuritaire, la plaçant dans une position de force vis-à-vis de la Moldavie. Cependant, puisqu’une reconnaissance étatique n’a jamais été accordée à la RMP, cette dernière a donc hérité d’un déficit symbolique que seule la Moldavie pouvait lui octroyer par la reconnaissance. Une politique active de reconnaissance envers la RMP entre 1994 et 1998 a été le facteur déterminant dans la transformation du conflit, conduisant à la signature de trois « grands accords ». Le célèbre Mémorandum de Moscou de 1997 a souligné ce processus transformatif au travers duquel les deux « opposants » se sont dès lors considérés comme « partenaires » au sein des négociations. Au cours de l’année 1998, Chisinau et Tiraspol se sont engagées sur le chemin de la paix en adoptant des mesures de confiance et de sécurité avec l’Accord d’Odessa
The Moldovan civil conflict between 1989 and 1992 left the country and the people permanently divided between the banks to the Dniestr/Nistru River. Despite Pridnestrovia’s (PMR) victory in its war of independence, it would not achieve its goal of being a recognized state. The ceasefire agreement of 1992 officially put an end to the war and solidified Prinestrovia’s separation through the creation of a security zone and the establishement of peacekeeping forces. Furthermore, the resolution of the conflict and the end of the new status quo had to be synchronized with the accordance of a new political status for the PMR. As an official status was never determined, the conflict has remained frozen. During the post-war period, the balance of power favored the PMR from an economic, energy and security perspective, providing it with major leverage over Moldova. However, given that the PMR was never attributed statehood meant that it inherited a symbolic deficit because only Moldova could provide it with recognition. Moldova’s policy of recognition towards the PMR between 1994 and 1998 would be the determing factor in the transformation of the conflict, leading to the signing of three “major accords”. The historic Moscow Memorandum of 1997 highlighted this transformative process by which the two “opponants” considered eachother as “partners” within the negociation process. By 1998, Chisinau and Tiraspol embarked upon the path of confidence building and security measures with the Odessa Accord of 1998

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Bigová, Ľubomíra. "Vybrané vnútorné problémy Číny a ich potenciálne implikácie na postavenie štátu v medzinárodných vzťahov." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-113682.

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During last 30 years status of China within international relations has undergone a significant change. However, there are some internal problems that prevent China from taking its power status and realize its role as an important actor of international society. The basic assumption is that the internal affairs determine the state behavior on the global level. The objective of the Master thesis is to analyze how the internal problems of China influence its position within international relations, find out the impact of current issues and their potential implications on foreign policy, and to discuss to what extent particular aspects influence future development of China. Thesis introduces current internal problems in politic, energy and economic sector. Afterwards, application of particular theoretical schools is performed. Moreover, possible scenarios of future development are presented, e.g. to what extent are internal problems able to influence current rise of China and determine its future status within the international system -- rise, fall or status quo.

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Singha, Justin. "L'Eglise catholique et l'Etat en République du Congo : une étude juridique et politique." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0328.

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L'Eglise catholique en République du Congo exerce un pouvoir politique non négligeable. Cette action politique de l'Eglise dépend du statut juridique dont bénéficie l'Eglise dans le droit positif congolais. La complexité structurelle de l'Eglise catholique dépasse le cadre associatif qui définit les associations religieuses au Congo. La définition du statut canonique et civil de l'Eglise catholique permet d'apprécier son impact au plan socio-politique et sa relation avec l'Etat
The Catholic church plays a not insignificant role in the political transition in Congo Brazzaville. However, it is useful to define its legal status in order to evaluate its socio-political expression. The definition of this legal status allows the Catholic Church to be able to carry out its activities with legal protection

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Ike, Chinweoke Uzoamaka. "Measuring household food security status in Taraba State, Nigeria : comparing key indicators." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96765.

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Thesis (MPhil)--Stellenbosch University, 2015.
ENGLISH ABSTRACT: Achieving food security and reducing hunger requires comprehensive measurement for proper identification of the food insecure, the severity of food insecurity, its causes, and progress in reducing food insecurity. Measuring food security is challenging due to its multidimensional nature as all four dimensions (availability, access, utilisation, and stability) need to be achieved simultaneously. Comprehensive measurement has not been achieved as most existing indicators have a unidimensional focus and efforts to find a ‘composite indicator’ (a catch all measurement tool) have thus far been unsuccessful. This study therefore identified how the three most widely used indicators of food security, the Household Food Insecurity Access Scale (HFIAS), Dietary Diversity Score (DDS) and the Coping Strategies Index (CSI), can complement one other in capturing the multiple dimensions of food security. The study brought them together in one cross-sectional household survey of 409 randomly selected households in Taraba State, Nigeria. The results show that 69 percent of households in Taraba had a very low food security status, 23 percent had low food security, and 8 percent had high or marginal food security. About 34 percent of the households used very erosive coping strategies. Very low food security status was found to be associated with: a household head who is a farmer, less educated, or divorced; low household income and expenditure; large household size; and not owning large plots of land. The survey revealed that most households that obtain the greater proportion of their food from own production, and spend most of their income on the purchase of starchy staples were in the very low food security category. Those that sourced their food mainly through purchase, and spent more on fresh fruit and vegetables, meat, fish, eggs, and processed foods were in the high or marginal food security category. The study showed that the key indicators followed a clear complementary pattern. The bivariate analysis showed a significant difference (P<0.01) in DDS and CSI across HFIAS categories. The HFIAS very low food security category is characterised by the lowest food diversity and highest CSI, revealing that the depth of food insecurity is intense among the extreme group. The study demonstrated that these three indicators can be used together for a fuller understanding of the relationships between the different dimensions of food security, and recommended more studies in using complementary indicators to measure food security. This thesis is presented as the two academic articles option: the first article reviews the measurement of food security and complementarity of the three measures, while the second article discusses the findings of the survey.
AFRIKAANSE OPSOMMING: Die bereiking van voedselsekerheid en die bekamping van hongersnood vereis omvattende meting vir die korrekte identifikasie van voedselonsekerheid, die erns daarvan, die oorsake daarvan, en die proses van voedselonsekerheidvermindering. Die meting van voedselsekerheid is ŉ uitdaging as gevolg van die multidimensionele aard daarvan, aangesien die onderskeie dimensies (beskikbaarheid, toegang, benutting, en stabiliteit) tegelyktydig bereik moet word. Omvattende meting is nog nie bereik nie, aangesien bestaande aanwysers ŉ eendimensionele fokus het, en aangesien pogings om ŉ ‘saamgestelde aanwyser’ (‘n allesomvattende metingsinstrument) te vind, tot dusver onsuksesvol was. Hierdie studie het dus geïdentifiseer hoe die drie mees algemene aanwysers vir voedselsekerheid, naamlik die Huishoudelike Voedselonsekerheid Toegangskaal (HFIAS), die Dieetkundige Diversiteitstelling (DDS) en die Hanteringstrategieë Indeks (CSI), mekaar kan aanvul om die verskeie dimensies van voedselsekuriteit vas te vang. Die studie het die bogenoemde instrumente saam geïmplementeer in ŉ deursnee-huishoudelike opname van 409 ewekansig-geselekteerde huishoudings in Taraba Staat, Nigerië. Die resultate het 69 persent van huishoudings in Taraba met ‘n baie lae voedselsekerheid-status getoon, 23 persent met ŉ lae voedselsekerheid-status, en 8 persent met ŉ hoë of geringe voedselsekerheid-status. Ongeveer 34 persent van die huishoudings het baie verwerende hanteringsstrategieë gebruik. Baie lae voedselsekerheid-status is bevind om meer geassosieer te word met: ŉ huishoudelike hoof wat ŉ boer is, minder opgevoed is, of geskei is; waar daar lae huishoudelike inkomste en uitgawes teenwoordig is; ŉ groot huishoudelike grootte; en die nie-besitting van eiendom. Die opname het geopenbaar dat die meeste huishoudings wat die grootter proporsie van hulle voedsel vanaf eie produksie verkry, en die meeste van hulle inkomste op die aankoop van styselagtige stapelvoedsel spandeer, in die baie lae voedselsekerheid-kategorie geval het. Diegene wat hulle voedsel hoofsaaklik deur aankope verkry het, en meer spandeer het op vars vrugte, groente, vleis, vis, eiers en geprosesseerde kosse, was in die hoë/ geringe voedselsekerheid kategorie. Die studie het bevind dat die sleutelaanwysers ŉ duidelike aanvullende patroon gevolg het. Die tweeveranderlike ontleding het ŉ beduidende verskil (P<0.01) in DDS en CSI oor HFIAS-kategorieë getoon. Die HIFIAS baie lae voedselsekerheidkategorie word gekenmerk deur die laagste voedseldiversiteit en hoogste CSI, wat openbaar dat die diepte van voedselonsekerheid intensief is onder die uiterste groep. Die studie het gedemonstreer dat hierdie drie aanwysers saam gebruik kan word om ŉ beter begrip van die verhoudings tussen die verskillende dimensies van voedselsekuriteit te verkry, en daar is aanbeveel dat meer navorsing onderneem word aangaande die gebruik van aanvullende aanwysers om voedselsekuriteit te meet. Hierdie tesis word aangebied as die twee-akademiese-artikels opsie: die eerste artikel bied ŉ oorsig van die meting van voedselsekerheid en die aanvullendheid van die drie instrumente, terwyl die tweede artikel die bevindinge van die studie bespreek.

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Hawke, Josephine M. "Ecological structure and status change : exploring the spatial outcomes of state intervention /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487694389395583.

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Eltilib, Elturabi Galal Khalifa. "Oral health status among children with special needs in Khartoum State, Sudan." University of Western Cape, 2012. http://hdl.handle.net/11394/3388.

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Magister Scientiae Dentium - MSc(Dent)
Introduction: Children with disabilities and other special needs present unique challenges for oral health professionals in the planning and execution of dental treatment. The oral health of children with special health care needs is influenced by various socio-demographic factors, including their living conditions and severity of the impairment. According to United States (US) Maternal and Child Health Bureau, special health care needs (SHCN) children are defined as “those who have or are at increased risk for a chronic physical, developmental, behavioral, or emotional condition and who also require health and related services of a type or amount beyond that required by children generally”. Aim and Objectives: The aim was to determine the oral health status of children with special needs. The objectives were to determine the prevalence of dental caries, periodontal disease and oral mucosal lesions among children with special needs in Khartoum State aged 5 to 15 years old attending educational and rehabilitation institutions. Methodology: A descriptive cross–sectional study was carried out. Data were collected with a data capture sheet that was a modified WHO Oral Health Assessment Clinical Oral Examination Guideline. Demographic variables, dmft, periodontal disease and oral mucosal lesions were recorded. Results: The mean dmft /DMFT scores was 2.02/1.25. The DMFT score increased with age, girls showed higher score than boys and autistic children had the poorest oral health among other disabilities. More than two third of the examined sextants were healthy, less than quarter had bleeding (18.3%) and 5% calculus accumulation. Fissured tongue was the most frequent oral lesion found. Conclusion: Children with special needs in Khartoum State demonstrated a high prevalence of dental caries and periodontal disease and do not receive adequate dental care. There is an urgent need for both preventive and treatment programmes to improve the oral health of children with special needs.

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BUSCA, CLAUDIA. "Integrated Approaches For The Monitoring And Assessment Of Environmental Status Of The Adriatic Sea In The Framework Of The European Marine Strategy Directive." Doctoral thesis, Università Politecnica delle Marche, 2017. http://hdl.handle.net/11566/245300.

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Ad oggi esistono fortissime evidenze che le attività antropiche stanno causando rapidi cambiamenti alle dinamiche degli ecosistemi marini. Molti di questi cambiamenti stanno già avvenendo negli oceani del nostro pianeta, con potenziali conseguenze negative nelle prossime decadi. La Direttiva Quadro sulla Strategia Marine (MSFD, 200856/EU), approvata nel 2008 dal Consiglio Europeo e dal Parlamento Europeo, richiede agli Stati Membri di fornire informazioni sullo stato di salute dei mari di loro pertinenza " stabilendo un quadro per le azioni comunitarie nel campo delle politiche ambientali marine", e le relative strategie da adottare per migliorare la qualità degli ecosistemi marini al fine di assicurare lo sfruttamento delle risorse anche alle generazioni future. L'obiettivo principale di questa tesi di dottorato è quello di identificare pattern utili alla definizione del buono stato ambientale (GES) come richiesto dalla Direttive Europea per i descrittori 5 (eutrofizzazione) e 7 (alterazioni idrografiche) della Direttiva, attraverso l'integrazione di dati fisici e biologici misurati in situ, dati da satellite e output di modelli revisionali a diverse scale spazio temporali. Al fine di comprende meglio anche le dinamiche a piccola scala, sono stati elaborati dati relativi alla portata dei fiumi e al carico dei nutrienti che si immette nelle zone costiere della Regione Marche e il loro impatto sulle acque marine costiere. I risultati di questo studio hanno evidenziato nel periodo preso in esame cambiamenti differenti a grande e piccola scala. Se a scala di bacino il mare Adriatico sta subendo negli ultimi anni un riscaldamento delle acque, con corrispondente aumento della biomassa fitoplantonica, e un innalzamento del valori di salinità, a scala locale le dinamiche marine sembrano più influenzate dalle dinamiche fluviali. Questi risultati permettono di definire delle linee guida necessarie per sviluppare soglie e determinare adeguati standard per le acque del Mare Adriatico, oltre a migliorare la conoscenza della variabilità temporale sia del bacino adriatico sia a scala locale, dove la forzante principale è rappresentata dalle dinamiche fluviali.
There are growing evidence that human activities together with climate change are driving profound changes of marine ecosystems with important repercussions on the goods and services they provide for human wellbeing. The Marine Strategy Framework Directive (MSFD, 2008/56/EU), approved in 2008 by the European Parliament and transposed at Italian level in 2010 (Legislative Decree 190/2010), requires Member States to provide information on marine environmental status and to take the necessary measures to achieve or maintain Good Environmental Status (GES) of the marine environment by the year 2020. The main objective of this PhD thesis is to improve knowledge on the trophic and thermohaline conditions of the Adriatic Sea related to descriptors 5 (eutrophication) and 7 (hydrographic alterations) which are included in the MSFD and used along with other 9 descriptors for the assessment of GES, through the use and integration of outputs of predictive models, physical and biological data measured in situ and satellite data analyzed at different spatial and temporal scales. In order to better clarify dynamics occurring at local scale, data on thermohaline and biogeochemical characteristics of coastal waters of Marche Region have been acquired along with information on the river outflows and nutrient load. Results of this study highlight that during the investigated period temporal patterns occurring at the basin scale are different than those observed at local scale. In particular, while at the basin an increase of water temperature and salinity together with an increase of the phytoplankton biomass have been observed in the last 10-15 years, at a local scale patterns of thermohaline and biogeochemical characteristics on a decade are generally opposite and influenced by the river dynamics. Overall results of this study on the one hand highlight the importance of using integrated tools and approaches for the study of the thermohaline and biogeochemical characteristics at different spatial scales (Adriatic basin vs. local scale), and on the other represent an important benchmark for a better understanding of the functioning of the Adriatic Sea and the potential changes that could affect the achievement of GES and its maintenance over time.

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FRANCO, Loris. "Verifica dell’applicabilità del metodo irriguo sub-superficiale su colture agrumicole e ottimizzazione dell’uso della risorsa idrica." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395385.

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Gli impianti di subirrigazione (SDI), in relazione alla posizione interrata dei gocciolatori permettono la riduzione dei consumi irrigui, garantendo la possibilità di utilizzo di risorse altrimenti non utilizzabili. Tuttavia, i costi di investimento iniziali risultano maggiori di quelli relativi ai tradizionali impianti di microirrigazione e pertanto, diventano economicamente vantaggiosi, se l'efficienza del sistema viene garantita per periodi di almeno 15-20 anni. La SDI, inoltre, permette di ottenere valori elevati di efficienza d’uso dell’acqua, spesso superiori al 90%, se associata ad un monitoraggio continuo dello stato idrico del suolo e della pianta e ad una corretta stima delle esigenze della coltura. L’utilizzo congiunto di impianti efficienti e gestione irrigua deficitaria, DI, durante specifiche fasi del ciclo fenologico delle colture può dunque permettere di ridurre ulteriormente i volumi irrigui senza comprometterne il risultato produttivo. Risulta pertanto necessario individuare sistemi capaci di proteggere gli impianti ed allungarne la vita utile, circostanza questa che si traduce in una protezione degli erogatori da possibili fenomeni di intrusione radicale, oltre che sviluppare dei sistemi di monitoraggio capaci di rilevare in tempo reale e da remoto le variabili del sistema Suolo-Pianta-Atmosfera (SPA), in modo da supportare l’agricoltore nella programmazione dell’irrigazione, anche sulla base di strategie di gestione in condizioni di deficit idrico. Obiettivo generale del presente studio, come previsto nel progetto di dottorato di ricerca industriale concordato con la società Irritec s.p.a. e con il Dipartimento di Ingegneria rurale ed Agroalimentare dell’Università Politecnica di Valencia, è stato quello di analizzate le principali problematiche ed i possibili sviluppi futuri della subirrigazione. L’attenzione, nello specifico, è stata focalizzata sulla problematica dell’intrusione radicale e dell’invecchiamento di gocciolatori auto-compensanti installati all’interno di linee gocciolanti interrate a servizio di piante di agrume installate in vaso, oltre che sul risparmio idrico conseguibile in pieno campo attraverso gli impianti di subirrigazione, in assenza ed in presenza di condizioni di deficit idrico, rispetto ai sistemi irrigui a spruzzo tradizionalmente impiegati per la coltura dell’agrume. Con riferimento al primo aspetto, è stata valutata l’efficacia di cinque principi attivi anti-intrusione radicale, Rame (Cu), Cianammide a due diverse concentrazioni CY1 (1,25%), CY2 (2,5%), e due diversi erbicidi, il Trifluralin (R1) ed il Preventol® (R2), contenuti all’interno di gocciolatori auto-compensanti installati lungo linee gocciolanti integrali prodotte da Irritec s.p.a., al fine di identificarne i possibili effetti sulla crescita dell’apparato radicale ed aereo di un comune portinnesto di agrume (citrange “Carrizo”). Per valutare gli effetti sullo sviluppo radicale, le piante sono state trapiantate all’interno di contenitori suddivisi da un setto che ha permesso la crescita indipendente delle radici nelle due metà del volume radicale irrigate rispettivamente da un gocciolatore contenente un principio attivo e da un gocciolatore di controllo. L’utilizzo di un minirizotrone costruito allo scopo, ha permesso di monitorare la crescita dell’apparato radicale nell’intorno del gocciolatore. Al fine di identificare gli effetti dei diversi principi attivi sullo sviluppo della pianta, alla fine dell’esperimento, è stato effettuato un rilievo distruttivo che ha permesso di valutare il peso delle singole componenti della pianta (radici, fusto, rami e foglie). Al termine dell’esperimento i gocciolatori sono stati sottoposti a prova in modo da valutare la relazione portata-pressione e rilevare le eventuali radici presenti all’interno di ciascun erogatore. Per quanto concerne il secondo aspetto, invece, su un agrumeto commerciale di circa 30 anni è stata effettuata la riconversione di un impianto irriguo tradizionale a spruzzo con un più moderno impianto in subirrigazione, nel quale è stato effettuato il monitoraggio in tempo reale del sistema Suolo-Pianta-Atmosfera (SPA) per la determinazione dei parametri di programmazione dell’irrigazione, oltre che per valutare gli effetti dell’applicazione di condizioni di deficit idrico controllato (Deficit irrigation, DI) sullo stato idrico della pianta, sui flussi traspirativi e sullo sviluppo vegetativo estivo. L’esperimento ha permesso altresì di di determinare i valori del coefficiente colturale basale Kcb e del coefficiente di stress Ks caratterizzanti le condizioni pedo-climatiche esaminate. Per valutare l’efficacia, a scala aziendale, di tre dei principi attivi esaminati con le prove in vaso, sono stati realizzati a scala di campo, quattro distinti trattamenti, nei quali sono state installate ali gocciolanti contenenti Rame (Cu) e due diversi erbicidi, il Trifluralin (R1) ed il Preventol® (R2), oltre ad un trattamento di controllo nel quale sono state installate ali gocciolanti senza alcun principio attivo. Metà della superficie è stata gestita in condizioni di DI, mentre l’altra metà in condizioni di rifornimento irriguo ottimale (Full irrigation, FI). Il monitoraggio della funzionalità degli erogatori nel tempo è stato effettuato sulla base di misure globali delle portate erogate da ciascun settore irriguo a parità di pressione di funzionamento dell’impianto. Il sistema di sensori (“drill & dropTM” ) installati ha permesso, durante il primo anno di studio di monitorare l’irrigazione aziendale gestita secondo le consuetudini locali, oltre che le variabili climatiche. Nel secondo e terzo anno di attività, è stato attivato l’impianto di subirrigazione, implementato il sistema di monitoraggio dello stato idrico della pianta mediante l’installazione di sensori (sap-flow e psicrometri) ed effettuato il monitoraggio del potenziale fogliare mediante camera pressiometrica di Scholander. Inoltre, per valutare gli effetti del deficit idrico sulla vegetazione, sono stati eseguiti rilievi sulla morfologia della chioma, sul LAI, sulla potatura e sulla sviluppo della vegetazione durante il periodo estivo. Nel corso del triennio di dottorato si è altresì proceduto, utilizzando il banco prova esistente presso il laboratorio di idraulica ed irrigazione dell’Università Politecnica di Valencia, alla caratterizzazione idraulica degli apparecchi erogatori installati in campo. I vari principi attivi esaminati, destinati ad inibire l’intrusione radicale, non hanno evidenziato effetti negativi diretti sullo sviluppo vegetativo di piante in vaso del portinnesto utilizzato (citrange ‘Carrizo’). L’intrusione radicale si è verificata in presenza di tutti i principi attivi con intensità e fenomenologia variabile; le relativamente migliori performance di protezione dai fenomeni di intrusione radicale sono state ottenute con gli erogatori contenenti Preventol® (R2). Nonostante i fenomeni di intrusione radicale abbiano interessato, in misura diversa, tutti i modelli di erogatore esaminati, la caratterizzazione idraulica dei gocciolatori effettuata dopo due anni di utilizzo ha permesso di rilevarne la funzionalità residua, che comunque può essere ripristinata con le normali operazioni di pulizia degli impianti. L’utilizzo delle moderne tecnologie dell’informazione e della comunicazione (ICT), integrate con sensoristica di monitoraggio dello stato idrico del suolo (sensori “drill & dropTM” Sentek), della pianta (sap-flow e psicrometri) e dell’atmosfera (stazione metereologica), ha permesso di creare un ambiente intelligente, capace di trasferire le informazioni in tempo reale attraverso specifiche applicazioni fruibili tramite cellulare o computer. Il sistema di sensori installati in pieno campo ha permesso di monitorare durante i tre anni di indagine, le dinamiche dell’acqua nel suolo e nella pianta in relazione alla richiesta evapotraspirativa dell’atmosfera. L’uso della subirrigazione, congiuntamente all’applicazione di strategie di irrigazione deficitaria ha permesso il contenimento dei volumi irrigui, con percentuali medie di risparmio idrico nel biennio 2018-2019 pari rispettivamente al 12,6% e 14,0% per le tesi in assenza di deficit idrico (FI) ed al 43,6 e 35,3 per le tesi mantenute in deficit idrico durante la fase II dello sviluppo vegetativo (DI) rispetto all’irrigazione tradizionale. Le informazioni acquisite hanno permesso di definire delle soglie di intervento irriguo basate sulla risposta della coltura allo stress idrico. Nello specifico, indipendentemente dal sito di misura, è stato identificato un valore soglia del potenziale idrico predawn, pd, pari a -0,45 MPa, al di sotto del quale si manifestano riduzioni di traspirazione effettiva rispetto alla potenziale. In corrispondenza di tale valore, nelle ore più calde della giornata sono stati misurati valori di stem, compresi tra -1,2 e -1,4 MPa. Lo studio delle dinamiche traspirative della coltura durante la stagione irrigua, con piante sottoposte a differenti strategie irrigue ha permesso, nei due anni di studio, sia di quantificare il coefficiente colturale basale (Kcb) relativo alla fase intermedia di sviluppo della pianta, che è risultato nei due anni pari a 0,40 (tesi FI), sia il coefficiente di stress (Ks) che, nelle condizioni esaminate, è risultato pari a 0,75 nel 2018 e 0,57nel 2019 (tesi DI). Lo studio condotto ha permesso quindi di identificare le relazioni tra le varie componenti del sistema SPA e quantificare i parametri utili per la gestione dell’irrigazione in modo automatizzato, oltre che di verificare l’utilizzabilità del metodo irriguo sub-superficiale su colture agrumicole al fine di ottimizzare l’uso della risorsa idrica.

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Piccoli, JoÃ£o Carlos Jaccottet. "History and status of physical education in state-controlled first-level schools in the state of South Rio Grande, Brazil /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259580263787.

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Baumgartner, Thomas. "Socio-economic status and teacher perceptions regarding the New York State ELA exam." Connect to resource online, 2009. http://library2.sage.edu/archive/thesis/ED/2009baumgartner_t.PDF.

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Thesis (E.Ed.)--The Sage Colleges, 2009.
"A Doctoral Research Project presented to Associate Professor Dr. Myers, Doctoral Research Committee Chair, School of Education, The Sage Colleges." Suggested keywords: high stakes testing; teacher perceptions; SES; student expectations; teacher recruitment and attrition; school accountability; instructional practice; ELA exam; state testing. Includes bibliographical references: (p. 70-74).

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Mateus, Medina Eder Fredy. "Papel de STAT1 y STAT3 en la tolerancia inducida por Staphylococcal enterotoxin B." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/325156.

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La inoculación de Staphylococcal enterotoxin B (SEB) en combinación con DGalactosamina en ratones BALB/c, induce shock tóxico y provoca la muerte al cien por cien de los ratones. Una pronta y elevada liberación de IL-2, IL-6, IFNγ y TNFα, así como una activación de STAT1 y STAT3 fueron observadas durante este proceso. Por el contrario, la inoculación periódica de bajas dosis de SEB modifico la respuesta y evito la muerte de los ratones tras inducirles el shock tóxico. Los niveles séricos de citocinas proinflamarorias IL-2 e IFNγ así como sus receptores celulares fueron bajos en estos ratones, mientras que los niveles de IL-10 fueron muy elevados. En el shock tóxico IFNγ fue el responsable de la marcada activación de JAK/STAT1 y de provocar la muerte ya que como se probó, al inhibir las Proteinas JAK con AG490 los niveles de IFNγ así como los de su receptor se redujeron y se evito la muerte. IL-6 fue quien activo STAT3 durante el shock tóxico mientras que IL-10 jugo un papel fundamental en la activación de STAT3 en los ratones tolerizados. EL papel relevante de las células CD4 fue determinado cuando los ratones control que recibieron los linfocitos T CD4 sobrevivieron a la muerte tras la inducción de shock tóxico. Adicionalmente, linfocitos T CD4 purificados a partir de ratones tolerizados, Durante el proceso de tolerización proteínas implicadas en la señalización vía TCR como DGKα

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Arévalo, Bautista Jazmine Paola. "The role of stat3 phosphorylation state in clear cell renal cell carcinoma (ccRCC)." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669570.

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STAT3 (signal transducer and activator of transcription 3) és un factor de transcripció latent que regula la transcripció de gens relacionats amb processos biològics essencials tals com: la diferenciació cel·lular, la proliferació, la migració, la inhibició de l’apoptosi i la supervivència. L’activació anormal d’STAT3 s’ha relacionat amb el desenvolupament d’aproximadament el 50% dels càncers humans, incloent el carcinoma renal de cèl·lula clara (ccRCC). Actualment, les propietats oncogèniques d’STAT3 s’atribueixen a la fosforilació del seu residu Tyr705; no obstant, recentment, la fosforilació de la Ser727 ha sorgit com un esdeveniment capaç d’amplificar l’activitat transcripcional d’STAT3, juntament a activitats no genòmiques que promouen el desenvolupament del càncer. El nostre grup va ser un dels pioners en assenyalar la importància de la fosforilació de la Ser727, demostrant que els nivells d’expressió de la pSer727 al nucli (en mostres de teixit de pacients de ccRCC) correlacionaven amb un mal pronòstic i una baixa supervivència global. Donat que el ccRCC és el subtipus histològic de carcinoma renal més prevalent i letal, i que els mecanismes subjacents al seu desenvolupament no han estat determinats fins el moment, l’objectiu d’aquest treball va ser elucidar el paper de l’estat de fosforilació d’STAT3 en el desenvolupament del ccRCC i, específicament, en estudiar la contribució de la pSer727 en la progressió tumoral. Amb aquesta finalitat, es varen generar fosfomutants simples i dobles d’STAT3 (Tyr705Phe, Ser727Ala, Ser727Asp, Tyr705Phe/Ser727Ala, i Tyr705Phe/Ser727Asp) que van ser transduïdes en línies cel·lulars humanes derivades de ccRCC (769-P i 786-O) per avaluar el seu comportament funcional, així com la conseqüent expressió gènica diferencial mitjançant l’anàlisi de microarray. Els nostres resultats han demostrat que les mutants d’STAT3 que contenien una substitució fosfomimètica de la Ser727 (Ser727Asp) promouen un fenotip pro-tumoral in vivo de manera independent a la Tyr705. A més, es descriu que l’estat de fosforilació global d’STAT3 determina l’expressió de diferents subconjunts de gens associats a diversos processos biològics, essent els gens dependents de la pSer727 els més relacionats amb processos característics amb el desenvolupament del càncer. En resum, aquest treball constitueix el primer anàlisi de quin és el paper de l’estat de fosforilació global d’STAT3 en el ccRCC, i demostra que la pSer727 activa la senyalització d’STAT3 a través de la transcripció d’un subconjunt específic de gens que són clínicament rellevants com potencials dianes terapèutiques i nous biomarcadors del ccRCC.
STAT3 (signal transducer and activator of transcription 3) es un factor de transcripción latente que regula la transcripción de genes relacionados con procesos biológicos esenciales, tales como: diferenciación celular, proliferación, migración, inhibición de la apoptosis y supervivencia. La activación anormal de STAT3 ha sido relacionada con el desarrollo de cerca del 50% de todos los cánceres humanos, incluyendo el carcinoma renal de célula clara (ccRCC). Actualmente, las propiedades oncogénicas de STAT3 se atribuyen a la fosforilación de su Tyr705; sin embargo, recientemente, la fosforilación de su Ser727 ha surgido como un evento capaz de amplificar la actividad transcripcional de STAT3, aunada a actividades no genómicas que promueven el desarrollo del cáncer. Nuestro grupo fue uno de los pioneros en señalar la importancia de la fosforilación de la Ser727, al demostrar que los niveles de expresión de pSer727 en el núcleo (en muestras de tejidos de pacientes con ccRCC) correlacionaban con un mal pronóstico y baja supervivencia global. Dado que el ccRCC es el subtipo histológico de carcinoma renal más prevalente y letal, y los mecanismos subyacentes a su desarrollo aún no han sido determinados, el objetivo de este trabajo fue elucidar el rol del estado de fosforilación de STAT3 en el desarrollo del ccRCC, y específicamente, en estudiar la contribución de la pSer727 en la progresión tumoral. Para ello, generamos fosfomutantes simples y dobles de STAT3 (Tyr705Phe, Ser727Ala, Ser727Asp, Tyr705Phe/Ser727Ala, y Tyr705Phe/Ser727Asp) que fueron transducidas en líneas celulares humanas derivadas de ccRCC (769-P y 786-O) para evaluar su comportamiento funcional, así como la consecuente expresión génica diferencial a través de un análisis de microarray. Nuestros resultados demostraron que las mutantes de STAT3 que contenían una substitución fosfomimética para la Ser727 (Ser727Asp) promueven un fenotipo pro-tumoral in vivo de forma independiente de la Tyr705. Además, describimos que el estado de fosforilación global de STAT3 determina la expresión de diferentes subconjuntos de genes asociados a distintos procesos biológicos, siendo los genes dependientes de la pSer727, los más relacionados con procesos característicos del desarrollo del cáncer. En resumen, este trabajo constituye el primer análisis acerca del rol del estado de fosforilación global de STAT3 en el ccRCC, y demuestra que la pSer727 activa la señalización de STAT3 a través de la transcripción de un subconjunto específico de genes que son clínicamente relevantes como potenciales dianas terapéuticas y nuevos biomarcadores para el ccRCC.
The signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor that regulates downstream genes involved in essential biological processes such as cell differentiation, proliferation, migration, apoptosis inhibition, and survival. The aberrant activation of STAT3 has been related to the development of near 50% of all human cancers including clear cell renal cell carcinoma (ccRCC). To date, the oncogenic properties of STAT3 are attributed to the phosphorylation of its Tyr705, however, the phosphorylation of its Ser727 has recently emerged as an event that enhances STAT3 transcriptional activity, in addition to non-genomic activities that promote cancer development. Our group was one of the pioneers in bringing the Ser727 phosphorylation to light by demonstrating that nuclear pSer727 expression levels, in tissue samples of ccRCC patients, correlated with poor prognosis and low overall survival. Since ccRCC is the most prevalent and lethal histological subtype of renal cell carcinoma (RCC) and the molecular mechanisms behind its tumorigenesis remain unclear, we aimed to elucidate the role of STAT3 phosphorylation state in ccRCC development, and especially the contribution of pSer727 to tumor progression. For that purpose, we generated simple and double STAT3 phosphomutants (Tyr705Phe, Ser727Ala, Ser727Asp, Tyr705Phe/Ser727Ala, and Tyr705Phe/Ser727Asp) transduced in human-derived ccRCC cell lines (769-P and 786-O), and we evaluated their functional behavior as well as their differential gene expression through microarray analysis. Our data demonstrated that STAT3 mutants carrying a phosphomimetic substitution for Ser727 (Ser727Asp) promote a pro-tumoral phenotype in vitro in a Tyr705-independent manner. Moreover, we describe that the overall STAT3 phosphorylation state determines the expression of different subsets of target genes associated with distinct biological processes, being pSer727-dependent genes the most related to cellular hallmarks of cancer development. In summary, the present study constitutes the first analysis on the role of overall STAT3 phosphorylation state in ccRCC and demonstrates that pSer727 activates STAT3 signaling through transcription of a specific subset of target genes that are clinically relevant as potential therapeutic targets and novel biomarkers for ccRCC.

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Mütze, Jörg. "Immunhistochemische Analyse der Leptin-induzierten Transkriptionsfaktoren STAT3 und STAT5 im Gehirn der Ratte." Wettenberg : VVB Laufersweiler, 2005. http://deposit.d-nb.de/cgi-bin/dokserv?idn=977309983.

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Greve, David. "Status und Statue Studien zu Leben und Werk des Florentiner Bildhauers Baccio Bandinelli." Berlin Frank & Timme, 2006. http://d-nb.info/985425768/04.

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Sisler, Jennifer. "Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/436.

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The signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune surveillance responses. In addition to their nuclear effects, we report that STAT1 and STAT2 inhibit the expression of mitochondrial encoded mRNAs by activating type I interferons (IFNβ) under basal conditions. STAT1-/- livers also exhibit elevated levels of nuclear encoded components of the electron transport chain (ETC). Treatment of wild-type mice with IFNβ inhibits both mitochondrial and nuclear transcription of the ETC components. The inhibition of mitochondrial encoded transcription by IFNβ is both STAT1 independent and dependent because it is also seen in STAT1-/- mice. This inhibitory action of IFNβ on mitochondrial transcription is mediated by a small pool of STAT1 and STAT2 residing within the mitochondria. This study would suggest a novel mechanism for STAT1 and STAT2, wherein they negatively regulate mitochondrial transcription and STAT1 coordinately regulates transcription of both mitochondrial and nuclear ETC components upon IFNβ stimulation. PGC1α has been described as the master regulator of mitochondrial biogenesis, and upon starvation its levels are elevated within the liver to increase mitochondrial biogenesis. The levels of PGC1α are increased in the STAT1-/- mice basally. However they are not increased further under starvation. Additionally, we report a novel phenotype of the STAT1-/- mice that suggests that they have a dysregulation of energy expenditure during starvation. We see that activation of hormone sensitive lipase which is the rate limiting step of lipolysis is attenuated in the adipose tissue of STAT1-/- mice and that there is less lipid accumulation in the livers of STAT1-/- compared to wild-type mice. The mechanism of STAT1’s role in energy regulation is not fully understood; however, this report would suggest that STAT1 does play a role within fasting homeostasis that is independent of IFNβ.

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Pangallo, Francesca <1989&gt. "Passaggi di Stato : traduzione e ricezione dell'opera di Primo Levi negli Stati Uniti." Doctoral thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/17833.

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La tesi propone un’analisi delle edizioni di Primo Levi in lingua inglese apparse negli USA dal 1959 ad oggi. La storia di ogni pubblicazione è finalizzata alla comprensione e valutazione della ricezione del testo e dell’autore da parte del pubblico statunitense, a seconda del periodo storico di riferimento. Le discrepanze a livello cronologico delle edizioni americane rispetto a quelle originali sono state accompagnate da lacune ed imperfezioni nella resa della traduzione, le quali hanno contribuito a delineare una tradizione dell’opera Levi in America differente da quella dello scrittore in Italia. Diverse variabili sono concorse a definire il quadro storico-sociale e letterario in cui Primo Levi è diventato un autore di successo nel panorama americano, prima fra tutte l’elaborazione e trasformazione della Shoah in oggetto culturale dagli anni Sessanta in poi. Questo fenomeno, unito alla diversa percezione che si ebbe del genocidio ebraico rispettivamente nei contesti italiano e statunitense del Secondo Dopoguerra, hanno costituito il punto di partenza iniziale entro cui ripercorrere le differenze e le assonanze che hanno caratterizzato la produzione di Levi fuori dai confini nazionali. In ultimo, si è cercato di individuare le difficoltà traduttologiche presenti nella lingua e nello stile dell’autore, concentrandosi da vicino sull’analisi e confronto di alcuni esempi di traduzione tratti direttamente dal testo.

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45

Pérez, Pinillos Jeniffer, Córdova Lucía Mercado, Baella Oscar Vega, and Velando Bernardo García. "Una visión del balance de poder sudamericano: seguridad regional, tensiones e integración en el siglo XXI." Politai, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/92501.

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El presente artículo aborda los cambios y continuidades en el balance de poder de la región sudamericana de las últimas décadas con el fin de entender los riesgos potenciales que ha enfrentado la seguridad del hemisferio sur desde inicios del siglo XXI. Luego de experimentar un largo proceso de integración regional lleno de iniciativas multilaterales de relativo éxito, América del Sur entró al año dos mil con una nueva configuración en las coaliciones regionales, que se tradujo en una intensa lucha entre liderazgos, que en algunos casos se presentaban hostiles entre sí. Este escenario llamó la atención de la comunidad académica y diplomática, ya que surgieron posibilidades de conflictos bilaterales aparentemente proclives a escalar hacia la violencia. No obstante, los últimos años han sido el reflejo de una nueva realidad que parece indicar que los temores de la última década fueron producto más de una coyuntura particular y menos del inicio de un reordenamiento en la región.

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46

Biart, Jérôme. "Les incompatibilités dans la fonction publique." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCD024/document.

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Afin d’éviter toute activité, fonction ou situation privée incompatible avec l’emploi public, le droit de la fonction publique s’inscrit dans un régime strict des prohibitions. Notre étude consiste à identifier les contraintes normées, générales et impersonnelles, et celles qui sont d’inspirations communes mais traduites différemment grâce à l’apport de la composante déontologique, les « incompatibilités fonctionnelles ». Nous précisons aussi les nouvelles hypothèses d’un possible aménagement de l’emploi public avec d’autres activités et les nouvelles règles dans la manière de prendre ses distances avec son service (le pantouflage). Enfin, comme il n’y a pas de réglementation professionnelle sans contrôle de son respect et sans sanction de sa violation, nous étudions les dispositifs préventifs et répressifs
The incompatibilities of the civil service.In order to avoid that any activity, service or private situation constituting an incompatibility with the pubic employment, the law on civil service is based on a strict regime of prohibitions. Therefore, our study consists on identifying standard, general, impersonal constraints, as well as constraints which despite being of common inspirations, have a different reflection with the contribution of the ethical component called "the functional incompatibilities".Additionally, we will precise the new assumptions of a possible modulation of the public employment along with other activities, and the new rules that govern the way distance can be taken with once service (the revolving door).Finally, and since no professional regulation exist without the control of its application and the sanctions of its violation, we will study the relative legal package of prevention and repression

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47

Anderson, Shirley Esther. "The status of faculty development programs in community colleges in the state of Washington /." Thesis, Connect to this title online; UW restricted, 1989. http://hdl.handle.net/1773/7571.

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Ogunmade, Taiwo Oludare. "The status and quality of secondary science teaching and learning in Lagos State, Nigeria." Connect to thesis, 2005. http://portal.ecu.edu.au/adt-public/adt-ECU2006.0042.html.

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O'Reilly, Foran Megan. "Representational status of minority students in special education in the State of Rhode Island /." View online ; access limited to URI, 2007. http://0-digitalcommons.uri.edu.helin.uri.edu/dissertations/AAI3276983.

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Mathers, Brittany L. "The status of and perceived barriers to physical activity of Ball State University students." Virtual Press, 2004. http://liblink.bsu.edu/uhtbin/catkey/1294895.

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The purpose of the study was to examine the status of and perceived barriers to physical activity of Ball State University students. Using a cross-sectional survey design, participants (N = 858) completed a self-report, 27-item questionnaire. Data were analyzed using univariate and bivariate analyses.The results indicated that the participants of this study have exceeded the Healthy People 2010 physical activity objectives for leisure-time physical activity and vigorous physical activity as well as the Health Campus 2010 objective for moderate and vigorous physical activity combined. Commonly reported barriers to physical activity were other priorities, lack of time, too tired, the weather, and other barriers. Being male, living in university housing, being an athlete, and being enrolled in a health-related academic major were all positively associated with participants' vigorous physical activity. Being female, living in university housing, commuting to Muncie, and being a full-time student were all positively associated with participants' increased barriers to physical activity.
Department of Physiology and Health Science

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Dissertations / Theses on the topic 'Statu'

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