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Academic literature on the topic 'Stapled'

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Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Stapled"

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Sturiale, Alessandro, Bernardina Fabiani, Claudia Menconi, Danilo Cafaro, Felipe Celedon Porzio, and Gabriele Naldini. "Stapled Surgery for Hemorrhoidal Prolapse: From the Beginning to Modern Times." Reviews on Recent Clinical Trials 16, no. 1 (February 15, 2021): 39–53. http://dx.doi.org/10.2174/1574887115666200310164519e.

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Introduction: Hemorrhoidal disease is the most common proctologic condition in adults. Among the different surgical procedures, one of the greatest innovations is represented by the stapled hemorrhoidopexy. The history of this technique started with a single stapler use passing through a double stapler technique to resect the adequate amount of prolapse, finally coming to the use of high volume devices. Methods: Nevertheless, each device has its own specific feature, the stapler is basically made up with one or more circular lines of titanium staples whose height may be variable. The procedure is based on different steps: Introduction of the CAD, evaluation of the prolapse, fashioning purse string or parachute suture, the introduction of the stapler head beyond the suture, pull the wires through the window, close the stapler and keep pulled the wires of the suture held together with forceps, fire using two hands, open the stapler and remove it and check the staple line and then check the specimen. One of the latest innovations in stapled surgery is Tissue Selective Therapy. It is a minimally invasive procedure in which there is a partial circular stapled hemorrhoidopexy focused on the prolapsing piles with bridges of normal mucosa left. Results: Several studies have reported that SH is a safe and effective procedure to treat hemorrhoidal prolapse. It is a quicker procedure with a shorter hospital stay and earlier return to work if compared with the conventional treatment. This is due to less postoperative pain, postoperative bleeding, wound complications and constipation. Furthermore, the first generation devices had worse outcomes if compared with those of the new generation stapler that showed lower postoperative complication rates with better anatomical and symptomatic results. Conclusions: Stapled procedure for the treatment of symptomatic hemorrhoidal prolapse represents one of the most important innovations in proctology of the last century bringing with it the new revolutionary concept of the rectal intussusception as a determining factor involved in the natural history of the disease. Stapled hemorrhoidopexy marked an era in which the surgeon may offer the patients a safe, effective treatment with less pain and fast recovery.
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Angotti, Lisa M., Christopher Decker, Brittany Pahwa, Carl Rosati, and Todd Beyer. "Internal hernia caused by a free intraperitoneal staple after laparoscopic appendectomy." Case Studies in Surgery 4, no. 1 (May 17, 2018): 14. http://dx.doi.org/10.5430/css.v4n1p14.

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Background: Laparoscopic appendectomy is the gold standard for treatment of appendicitis. Stapled closure of the appendiceal stump is commonly performed and has several advantages. Few prior cases have demonstrated complications from free staples left within the abdomen after the stapler has been fired.Case report: A 29-year-old female underwent laparoscopic appendectomy for acute uncomplicated appendicitis during which the appendix and mesoappendix were divided using laparoscopic gastrointestinal anastomosis (GIA) staplers. Her initial recovery was uncomplicated. She returned on postoperative day 17 with sharp mid-abdominal pain, obstipation, and emesis. Her abdomen was distended, and she had a mild leukocytosis. Computed tomography (CT) demonstrated twisted loops of dilated small bowel in the right lower quadrant with two transition points, suggestive of internal hernia with closed loop bowel obstruction. Diagnostic laparoscopy was performed through the three prior appendectomy incisions. An adhesion between the Veil of Treves and the mesentery of the ileum caused by a solitary free closed staple, remote from the staple lines, had caused an internal hernia. The hernia was reduced, and the small bowel was noted to have early ischemic discoloration. The adhesion was lysed by removing the staple from both structures. The compromised loops of bowel began to show peristaltic movement and color returned to normal, and the procedure was concluded without resection. She was discharged home the following day.Conclusions: Gastrointestinal staplers are commonly used due to ease of use and low complication rate. It is not uncommon to leave free staples in the abdomen as retrieval can be difficult and time consuming. Our case is only the second in the literature reporting an internal hernia with closed loop bowel obstruction as a complication of retained staples. Choosing the most appropriate size staple load to reduce the number of extra staples, removing free staples, or the use of an endoloop can prevent potentially devastating complications.
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Mari, Francesco Saverio, Luigi Masoni, Umile Michele Cosenza, Francesco Favi, Giammauro Berardi, Anna Dall'Oglio, Fioralba Pindozzi, and Antonio Brescia. "The Use of Bioabsorbable Staple-Line Reinforcement Performing Stapled Hemorrhoidopexy to Decrease the Risk of Postoperative Bleeding." American Surgeon 78, no. 11 (November 2012): 1255–60. http://dx.doi.org/10.1177/000313481207801135.

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Postoperative staple-line bleeding after stapled hemorrhoidopexy represents a major issue of this procedure, especially in the day surgery setting. In this study we assess the possible benefit of using circular bioabsorbable staple-line reinforcement to reduce the risk of hemorrhage when performing stapled hemorrhoidopexy in a day surgery setting. Patients with symptomatic II to III grade hemorrhoidal disease were randomly assigned into two groups. In Group A we performed a stapled hemorrhoidopexy using PPH33-03® with Seamguard®, a bioabsorbable staple-line reinforcement; in Group B, we used only a PPH33-03® stapler. We evaluated the intraoperative and postoperative staple-line bleeding and, secondarily, the duration of surgery, need for additional hemostatic stitches, and presence of postoperative complications. One hundred patients were enrolled in the study. Group A patients showed a statistically significant decrease of intraoperative bleeding (4 vs 42% in Group B) and hemostatic stitch placement (5.7 vs 42%) with the consequent reduction in mean operative time, postoperative pain, and tenesmus. There were no differences between the two groups in hemorrhoidal disease control or postoperative late complications. The use of bioabsorbable staple-line reinforcement while performing stapled hemorrhoidopexy may allow improvement of the safety of this procedure, especially in a day surgery setting.
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Subhedar, Preeti D., Sameer H. Patel, Peter J. Kneuertz, Shishir K. Maithel, Charles A. Staley, Juan M. Sarmiento, John R. Galloway, and David A. Kooby. "Risk Factors for Pancreatic Fistula after Stapled Gland Transection." American Surgeon 77, no. 8 (August 2011): 965–70. http://dx.doi.org/10.1177/000313481107700811.

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The objective of this study was to identify risk factors for pancreatic fistula (PF) after stapled transection in distal pancreatectomy (DP). Patients undergoing DP using a stapler for transection between 2005 and 2009 were identified from a pancreatic resection database. Variables examined included patient and tumor characteristics, staple size, and the use of mesh reinforcement. Univariate and multivariate regression analyses were performed to identify risk factors for postoperative PF. One hundred forty-nine had stapled transection, and of these, 25 (17%) had mesh reinforcement. The overall morbidity and mortality rates were 28 per cent and less than 1 per cent; 34 (23%) were diabetic. The rate of clinically significant PF was 14 per cent. On univariate analysis, diabetes ( P = 0.04), a firm pancreas ( P = 0.03), use of mesh staple line reinforcement ( P = 0.02), use of a 4.1-mm staple cartridge ( P = 0.01), and blood loss greater than 100 mL ( P = 0.01) were associated with higher pancreatic fistula rates. On multivariate analysis, only the presence of diabetes (OR, 4.17; 95% CI, 1.1-15.3; P = 0.03) and the use of a 4.1-mm cartridge (OR, 8.57; 95% CI, 1.2-60.2; P = 0.03) were independently associated with pancreatic fistula formation. Stapled pancreatic transection provides an acceptable PF rate after DP. Diabetes and staple size influence PF rates. In our experience, use of mesh staple line reinforcement did not reduce the incidence of PF after stapled transection.
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Marcet, Jorge, Andrea Ferrara, David E. Rivadeneira, Jose Erbella, and Harry T. Papaconstantinou. "Prospective, Multicenter Randomized Controlled Trial Comparing Two Hemorrhoidopexy Staplers: The HEMOSTASIS Study." International Surgery 103, no. 3-4 (March 1, 2018): 129–38. http://dx.doi.org/10.9738/intsurg-d-15-00171.1.

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The objective of this study was to compare two hemorrhoidopexy staplers (EEA versus PPH03). Stapled hemorrhoidopexy is a treatment option for patients with symptomatic internal hemorrhoids who have failed more conservative measures. However, staple line bleeding remains common. Recent improvements in stapler design have attempted to reduce intraoperative bleeding and the need for intervention. HEMOSTASIS is a prospective, multicenter, 1:1 randomized controlled trial. Twelve hospital centers in the United States enrolled participants between 18 and 85 years of age with symptomatic grades 2 to 3 internal hemorrhoids. The primary end point was intraoperative bleeding, defined as bleeding requiring intervention (e.g., placement of sutures, cauterization, or ligation to achieve hemostasis). Secondary end points included staple line location, postoperative pain, quality of life, operative time, length of hospital stay, adverse events, and complication rates. On the primary end point, the rates of intraoperative bleeding requiring intervention were 41.0% (32 of 78) with EEA and 70.4% (50 of 71) with PPH (P < 0.001). Treatment for active bleeding was required in 30.8% versus 57.7% (P < 0.001) in the EEA and PPH arms, respectively. There were no significant differences between groups in postoperative pain. Adverse events and perioperative complication rates were generally mild/moderate and were similar between groups: 74.1% (60 of 81) of patients in the EEA group reported at least one adverse event versus 80.9% (55 of 68) in the PPH group (P = 0.32). Intraoperative bleeding occurred less often after stapled hemorrhoidopexy with the EEA stapler compared with the PPH03 stapler. Intervention to achieve hemostasis was required less often with the EEA stapler.
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ALKAN, Murat, Kamuran TUTUŞ, Selcan TÜRKER ÇOLAK, Ender FAKIOĞLU, Şeref Selçuk KILIÇ, Onder OZDEN, and Recep TUNCER. "Comparison of stapler and hand-sewn roux en Y jejunal anastomosis in children." Cukurova Medical Journal 47, no. 4 (December 28, 2022): 1424–30. http://dx.doi.org/10.17826/cumj.1091286.

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outcomes of stapled and hand-sewn Roux-en-Y intestinal anastomoses in childhood. Materials and Methods: At a university hospital, the records of the children who underwent roux-en-Y anastomosis between December 2007 and December 2014 were reviewed. The data were compared according to the roux-en-Y anastomosis technique used (stapled versus hand-sewn). Results: A total of 52 patients had undergone roux-en-Y anastomosis. All had biliary atresia or choledochal cyst. Thirty-one of the patients were diagnosed with biliary atresia and 21 with choledochal cysts. Staple anastomosis technique was used in 16 of the patients with biliary atresia and 9 of the patients with choledochal cyst. Both in biliary atresia and choledochal cyst cases; operations with stapled anastomosis were significantly shorter than the ones with hand-sewn anastomosis. Among the biliary atresia cases, post-operative oral feeding was initiated significantly earlier in the stapled group, with its lower risks of post-operative cholangitis and longer hospital stay than 7 days. Conclusion: This is the first study in children, confirming the time-saving advantage of stapled anastomosis over hand-sewn, during roux-en-Y anastomosis for biliary atresia and choledochal cyst; along with the safety of stapler use, including the neonates. Stapled anastomosis yields lower complication rates, faster function gain with earlier feeding and hospital discharge.
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Sato, Masaaki. "Strategies to improve the accuracy of lung stapling in uniportal and multiportal thoracoscopic sublobar lung resections." European Journal of Cardio-Thoracic Surgery 58, Supplement_1 (March 12, 2020): i108—i110. http://dx.doi.org/10.1093/ejcts/ezaa051.

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Abstract The challenges in video-assisted thoracic surgery for sublobar lung resection include difficulty in tumour localization by palpation and difficulty in determining appropriate resection lines. Virtual-assisted lung mapping (VAL-MAP), a bronchoscopic preoperative multispot lung dye-marking technique, allows for both tumour localization and determination of resection lines. To facilitate stapler-based resection, the AMAGAMI or ‘incomplete grasping’ stapler technique is useful to adjust the alignment of the stapler and resection lines. However, when the lung tissue to be stapled is thick, there is unavoidable uncertainty in the staple line inside the lung. We experimentally demonstrated that up to 1 cm of slippage of lung parenchyma occurs at stapling when the stapled lung tissue is >1 cm thick. VAL-MAP 2.0 is a new generation of VAL-MAP combining multispot dye markings with intrabronchial microcoil placement, allowing for 3-dimensional lung mapping and intraoperative navigation using fluoroscopy. The uncertainty of stapling in the lung parenchyma can be partly overcome by VAL-MAP 2.0.
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Gupta, Paritosh, Dhruv N. Kundra, Amanpriya Khanna, Akanksha Aggarwal, and Kanu Kapoor. "Our initial experience of three versus two rows circular stapler devices for stapled hemorrhoidopexy: a single institution review of 224 cases." International Surgery Journal 7, no. 3 (February 26, 2020): 685. http://dx.doi.org/10.18203/2349-2902.isj20200505.

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Background: Stapled haemorrhoidopexy is a non-excisional approach for haemorrhoids as opposed to conventional open Milligan-Morgan and Ferguson closed haemorrhoidectomy techniques. It repositions the prolapsed haemorrhoid tissue and also causes vascular interruption to the haemorrhoids. This causes faster recovery and lesser post-operative pain.Methods: In authors institute, stapled haemorrhoidopexy was being carried out using two rows proximate PPH circular haemorrhoidal stapler. In February 2018, MIRUS three rows circular stapler was introduced. This is a retrospective observational study carried out at Artemis Hospital, Gurgaon, India. Authors studied records and operative notes of all patients who underwent stapled haemorrhoidopexy between February 2018 and September 2019 and compared key parameters.Results: A total of 224 patients underwent stapled haemorrhoidopexy between February 2018 and September 2019. 116 using MIRUS three rows circular stapler and 108 using two rows proximate PPH circular haemorrhoidal stapler. Most of the studied parameters were comparable with only significant statistical difference seen in higher use of haemostatic sutures in two rows stapler group compared to three rows stapler group. Haemostatic sutures were needed in three row stapler group for 27 patients and in two rows stapler group for 39 patients.Conclusions: Author’s initial experience shows slightly better haemostasis with three rows stapled haemorrhoidopexy with no significant difference in other parameters.
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Koh, Dean C. S., Denis M. O. Cheong, and Kutt Sing Wong. "Stapled Haemorrhoidectomy: Bothersome Staple Line Bleeding." Asian Journal of Surgery 28, no. 3 (July 2005): 193–97. http://dx.doi.org/10.1016/s1015-9584(09)60342-0.

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Contini, Elizabeth, Marisha L. Godek, Jennifer M. Whiffen, and Dwight G. Bronson. "Ex Vivo Pneumostasis Evaluation of a Variable-Height Staple Design." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 8, no. 4 (June 2013): 284–88. http://dx.doi.org/10.1097/imi.0b013e3182a6912a.

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Objective This study examined the effect of using a variable-height staple construct containing three rows of staples with heights of 3.0, 3.5, and 4.0 mm (staple leg length, medial to lateral) versus standard three-row single-height staplers (with staple heights of either 3.5 or 4.8 mm) for pneumostasis in healthy porcine and canine lung parenchyma to determine whether a single stapler that uses variable staple heights could perform as well as, or better than, existing single-height stapling devices. The work presented here used healthy animal tissues, in lieu of diseased tissue, which is extremely difficult to obtain and quantify. Methods Briefly, fresh explanted porcine and canine trachea-lung blocs were used for all testing. Tissue thicknesses were measured with a custom-design spring-loaded caliper before stapling with control and test articles to ensure that the tissue was of “appropriate” thickness for the stapler size (staple height) selected (per manufacturer's instructions for use). All tissue measurements were comparable across each area of lung tested, and both test and control devices were fired into the same tissue thicknesses. After stapling, the lungs were submerged in water, insufflated, checked for air leaks at four discrete (increasing) pressures, and scored using a predetermined scale. Statistical analysis was performed for n = 26 (3.5-mm staples), n = 29 (4.8-mm staples), and n = 26 or 29 (paired to the standard group) for the variable-height stapler (3.0-, 3.5-, and 4.0-mm staples). Results The results demonstrated that the test article comprising three rows of variable-height staples provided comparable pneumostasis with the standard three-row single-height staplers (with staple heights of either 3.5 or 4.8 mm) under the test conditions described. Conclusions A novel test article containing three rows of staples with heights of 3.0, 3.5, and 4.0 mm (variable-height stapler) showed promising results when compared with standard commercially available single-height staplers, performing as well as or better than the standard single-height staplers. This work demonstrates important first steps to proving equivalent device performance, which might facilitate the use of a variable-height stapler in place of multiple single-height staplers.
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Dissertations / Theses on the topic "Stapled"

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Bornscheid, Jens. "Stapled Stock = (Verbundaktien) /." Frankfurt am Main [u.a.] : Lang, 2006. http://www.gbv.de/dms/spk/sbb/recht/toc/502180196.pdf.

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Chu, Qian. "I. Targeted β-catenin Ubiquitination and Degradation Using Bifunctional Stapled Peptides II. Studies on Cell Penetration by Stapled Peptides." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11278.

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Hydrocarbon-stapled alpha-helical peptides represent a relatively new class of synthetic peptidomimetics capable of inhibiting protein-protein interactions. It has been shown that hydrocarbon "staples" spanning one or two helical turns in a peptide increase alpha-helical content and protease resistance, enhance target binding affinity, and promote cell penetration. This technology has been applied to the development of cell-permeable ligands targeting several intracellular targets. This dissertation describes efforts to further the development of stapled peptide technology.
Chemistry and Chemical Biology
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Thaha, Mohamed Adhnan. "Circular stapled anopexy in the treatment of haemorrhoidal disease." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521688.

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Lau, Nathan Yu Heng. "Double-click stapled peptides for inhibiting protein-protein interactions." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708627.

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Sharma, Krishna. "Strain-promoted stapled peptides for inhibiting protein-protein interactions." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288602.

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Protein-protein interactions (PPIs) are responsible for the regulation of a variety of important functions within living organisms. Compounds which can selectively modulate aberrant PPIs are novel therapeutic candidates for treating human diseases. Whilst PPIs have traditionally been considered as "undruggable", research in this area has led to the emergence of several effective methodologies for targeting PPIs. One such methodology is peptide stapling, which involves constraining a short peptide into its native alpha-helical form by forming a covalent link between two of its amino acid side-chains. The Sondheimer dialkyne reagent has previously been used in strain-promoted double-click cycloadditions with diazidopeptides to generate stapled peptides that are capable of inhibiting PPIs. However, the Sondheimer dialkyne suffers from poor water-solubility; it decomposes rapidly in aqueous solutions which limits its application in biological systems. This dissertation describes the design and synthesis of new substituted variants of the Sondheimer dialkyne with increased solubility and stability, that are suitable for application in strain promoted double click peptide stapling. In total, ten different derivatives were generated; of these, a meta-trimethylammonium substituted variant was found to have particularly high water-solubility and aqueous stability, as well as high azide reactivity. The substituted Sondheimer dialkynes were applied to the strain promoted double click stapling of p53-based diazido peptides in an effort to generate stapled peptide-based inhibitors of the oncogenic p53 MDM2 PPI, a validated target for anticancer therapeutics. Three stapled peptides were found to have inhibitory activity, thus demonstrating the utility of the novel dialkynes in the preparation of PPI inhibitors. The functionalised stapled peptide formed from a meta-fluoro substituted Sondheimer dialkyne was found to be the most potent inhibitor. All ortho-substituted Sondheimer dialkynes were found to be unreactive, whereas those with a meta-trimethylammonium substituent were highly reactive when compared to other meta-substituted dialkynes. These patterns in azide reactivity could be explained through X-ray crystallographic studies and density functional theory calculations.
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Saunders, Alexander William. "New approaches to stapled peptides targeting the p53-MDM2 interaction." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25664.

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Recent approaches to constraining peptide sequences into more structurally-defined α- helical secondary structures, so-called peptide stapling, are discussed. Stapled peptides are a class of therapeutics that have been shown to more effectively target protein-protein interactions, which are harder to target using a classical small-molecule therapeutic approach. Stapling a peptide constrains it into a well-defined secondary structure. This more accurately mimics the protein-protein interaction making the peptide a more viable therapeutic. Starting from the p53-MDM2 interaction, a protein-protein interaction with important implications in cell health, a known peptidyl inhibitor of this interaction was stapled and analysed for increased α-helicity. This was achieved by using monomers that utilise the copper (I) alkyne azide cycloaddition as a cross-linking methodology, which has been less well researched in the context of peptide stapling. The viability of a novel stapled peptomer inhibitor approach, accomplished using a new, optimised monomer synthesis, is investigated. Additionally, the synthesis of a ligand series designed for use in the copper(I) alkyne azide cycloaddition is also discussed.
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Liang, Rebecca Yue. "Probing Protein Interactions with Stapled Peptides: Myc Family and Insulin Receptor." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11063.

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One of the most exciting frontiers of expanding pharmacopeia to combat currently untreatable diseases is achieving specifically and potently disruption of unwanted protein-protein interactions where traditional small molecule drugs tend to fall short. Our laboratory has developed the methodology of peptide stapling and pioneered successful applications in multiple disease models since its induction over a decade ago. One common feature of past applications is the use of a single stapled peptide in helical form, derived from the natural binding interface of target proteins. This dissertation ventures into protein interactions that involve multiple components and sites and explores the extended use of stapled peptides in these volatile settings.
Chemistry and Chemical Biology
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Ito, Eiji. "Synthetic Absorbable Film for Prevention of Air Leaks After Stapled Pulmonary Resection." Kyoto University, 2002. http://hdl.handle.net/2433/149729.

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Edwards, Amanda Lee. "Dissecting and Targeting the PUMA and OLIG2 Control Points of Tumors of Neuroectodermal Origin with Stapled Peptides." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10886.

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Tumors of neuroectodermal origin are among the most aggressive and treatment-refractory forms of human cancer. While such tumors arise from a variety of defects, two key targets are the transcription factors p53 and OLIG2. We have developed stabilized peptides to study and target deregulated p53 and OLIG2 pathways in neuroectodermal cancers. PUMA (p53-upregulated modulator of apoptosis) is a BH3-only member of the BCL-2 protein family that regulates apoptosis in response to p53-dependent and p53-independent stress signals. The specific interactions that mediate the pro-apoptotic activity of PUMA remain controversial. We generated stabilized alpha-helices of BCL-2 domains (SAHB) peptides modeled after the BH3 effector domain of PUMA. Structural analyses determined that PUMA SAHB contacts BAX at both the N-terminal \(\alpha1/\alpha6\) trigger site and the canonical BH3 binding pocket, binding events that functionally activate BAX. Notably, both PUMA SAHB and PUMA protein pull-downs identified anti- and pro-apoptotic binding partners in a cellular context. As PUMA has been implicated in driving apoptosis in multiple neural cell types, we further demonstrated that treatment of neuroblastoma cell lines with a cell-permeable PUMA SAHB analog triggered dose-dependent apoptosis. Together, we find that the PUMA BH3 domain activates apoptosis through multimodal interactions with BCL-2 family proteins, and its mimetics may serve as prototype therapeutics in tumors of neural origin. Whereas suppression of p53 signaling and apoptosis are features of diverse tumor types, the basic helix-loop-helix (bHLH) transcription factor OLIG2 is selectively overexpressed in gliomas. Early in development, OLIG2 is responsible for maintaining progenitor cells in a replication-competent state. Tumor stem cells are believed to co-opt this OLIG2 functionality to continually repopulate glial tumors. To achieve its transcriptional function, OLIG2 must dimerize via its bHLH domain. Stabilized alpha-helices of OLIG2 (SAH-OLIG2) peptides of the OLIG2 bHLH domain were generated in an effort to disrupt this pathologic dimerization. While helical stabilization of several SAH-OLIG2 peptides was achieved, specific engagement and disruption of the native bHLH dimer did not occur, informing alternative design strategies for future targeting efforts. These studies underscored the importance of interrogating the OLIG2 dimeric structure and catalyzed the discovery of candidate OLIG2 interaction partners for therapeutic targeting.
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Yeo, David James. "Development and evaluation of novel hydrocarbon stapled peptidomimetics with future application to bionic proteins." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/7218/.

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Hydrocarbon stapling is a method of constraining a short polypeptide through the incorporation of alkenyl alanine unnatural amino acids, which are metathesised during peptide synthesis to afford a covalent crosslink on one face of the peptide. The purpose of 'stapling' is to improve the therapeutic properties of a peptide by improving transport properties and resistance to proteolysis. Stapling also reduces the conformational plasticity of a peptide, which in turn, should improve the potency of the crosslinked peptide with its binding partner. Alkenyl glycine ('monosubstituted') derivatives of amino acids have been previously synthesised, but overlooked for peptide stapling experiments. This project investigated the utility of monosubstituted amino acids as surrogates for hydrocarbon stapling with a therapeutically relevant family of proteins, the apoptosis regulator Bcl-2 family and p53 proteins. This led onto an investigation of the foundations of hydrocarbon stapling, to assess the extent that hydrocarbon stapling modulates potency through various biophysical and structural experiments. Hydrocarbon stapled peptides are classified as peptidomimetics within the field of foldamers, which aims to construct scaffolds from synthetic oligomers which can replicate the three dimensional topography and functionality of native proteins. Since the de novo design of synthetic proteins is out of reach, regions of proteins with distinct architecture have been replaced with mimetics to afford semi-synthetic proteins in a technique described as 'protein prosthesis'. The project also aimed to chemically synthesise a protein with four distinct helical regions, colicin immunity protein Im7, with the view to replace one of the helical regions with a stapled peptide or an oligobenzamide helix mimetic to afford a semi-synthetic protein to add to the growing field of secondary and tertiary structure mimetics.
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Books on the topic "Stapled"

1

Bornscheid, Jens. Stapled Stock: (Verbundaktien). Frankfurt am Main: P. Lang, 2006.

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Kasper, Juneann. Stapled duplexing job analysis. Little Falls, NJ: Minnella Enterprises, 1994.

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Bangerter, Paul. Weekend of the stapled monkey. Salt Lake City, Utah: Northwest Publishing, 1993.

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Stapled! and other experiences: A body of new essays. Diliman, Quezon City: University of the Philippines Press, 1991.

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Sad friends, drowned lovers, stapled songs: Conversations and reflections on twentieth century American poets. Grosse Pointe Farms, MI: Marick Press, 2011.

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Tauser, Kian. Stapled stocks, tracking stocks, mittelbare Organschaft: Gestaltungen zur Erhaltung des körperschaftsteuerlichen Anrechnungsguthabens bei grenzüberschreitenden Dividendenrouten. Konstanz: Hartung-Gorre, 2001.

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Staples, Garth E. The Staples family of Staples Brook. [Charlottetown, P.E.I.]: G.E. Staples, 1986.

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Morgan, Alison. Staples for Amos. London: Walker, 1986.

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Malolo, Meleʾofa. The staples we eat. Noumea, New Caledonia: South Pacific Commission, 1999.

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Malolo, Mele'ofa. The staples we eat. Noumea, New Caledonia: Secretariat of the Pacific Community, 1999.

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Book chapters on the topic "Stapled"

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Lorenzo-Rivero, Shauna. "Stapled Hemorrhoidectomy." In Operative Dictations in General and Vascular Surgery, 293–94. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-44797-1_83.

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Altomare, Donato F. "Stapled Hemorrhoidopexy." In Surgical Treatment of Hemorrhoids, 87–94. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84800-314-9_14.

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Stortoni, Pierpaolo, Emilio Feliciotti, Raffaella Ridolfo, and Walter Siquini. "Stapled Subtotal Gastrectomy." In Total, Subtotal and Proximal Gastrectomy in Cancer, 93–106. Milano: Springer Milan, 2015. http://dx.doi.org/10.1007/978-88-470-5749-4_5.

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Noren, Erik R., and Sang W. Lee. "Stapled Hemorrhoidectomy/-opexy." In Chassin's Operative Strategy in General Surgery, 583–87. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-81415-1_75.

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Espin, E., and F. Corbisier. "Stapled Hemorrhoidopexy: The Technique." In Transanal Stapling Techniques for Anorectal Prolapse, 71–83. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84800-905-9_7.

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Schneider, Benjamin E., and Daniel B. Jones. "Circular Stapled Transabdominal Technique." In Minimally Invasive Bariatric Surgery, 247–49. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-68062-0_28.

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Lauro, Enrico, Giovanni Scudo, and Salvatore Rizzo. "Endo-laparoscopic Retromuscular Repair." In Mastering Endo-Laparoscopic and Thoracoscopic Surgery, 469–73. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3755-2_65.

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AbstractAlthough few data exist to guide the management of rectus abdominis diastasis (RAD), during past decades many articles were published to describe techniques to correct RAD and concomitant abdominal midline defects. Among these, stapled techniques are acquiring an increasing interest.In this chapter we present the main surgical steps to perform an endoscopic retromuscular repair with the use of staplers.
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Remzi, Feza H., and Volkan Ozben. "Vaginal Injury During Stapled Anastomosis." In Gastrointestinal Surgery, 381–85. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2223-9_36.

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del Mar Aguilar Martínez, María, Pedro Moya, and Antonio Arroyo. "Stapled Hemorrhoidopexy: Techniques and Results." In Hemorrhoids, 1–16. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51989-0_27-1.

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García-Armengol, J., and J. V. Roig. "Main Advantages of Stapled Hemorrhoidopexy." In Hemorrhoids, 1–6. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51989-0_31-1.

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Conference papers on the topic "Stapled"

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Liao-yuan, Ai, Ge Shu-chen, Xu Jing-jing, Li Ming-yang, Mao Lin, and Song Cheng-li. "Finite Element Analysis and Experiment on Large Intestine End-to-End Anastomosis." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6832.

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Colorectal surgery is widely performed to re-establish the bowel, the part of which is removed because of diverticulitis, intestinal polyps, inflammatory bowel and cancer. Stapled anastomosis is a highly standardized technique and considered the standard of care. However, complications like leakage, stenosis and postoperative bleeding cannot be completely avoided [1,2]. There is limited understanding of the impact of staplers on tissue and basic mechanics of tissue stapling. According to the previous research, compression, staple height, tissue thickness, tissue compressibility, and tissue type have an effect on the patient outcomes [3]. Hence, we conducted this prospective study to analyze the effect of staple height on tissue damage and compression pressure. An attempt was made to determine the relationship between the tissue height and the optimal closed staple height.
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Kalapay, Dan, and Charles Kim. "Design of a Compliant Energy Storage Impulse Mechanism for a Desktop Stapler." In ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/detc2008-49451.

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This paper outlines the research, design and testing of a compliant staple gun style mechanism for use in a desktop model stapler. A survey of existing staple gun style desktop staplers is used to create target specifications to design the new compliant stapler. The initial proof of concept satisfies the primary function and user specifications. Future iterations of the mechanism will be tested and designed to be capable of performing the repeated iteration of long term stapler use.
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Koryllos, A., N. Kosse, and E. Stoelben. "single-PORT-non stapled VATS Lobektomie und Segmentektomie." In 26. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1605414.

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Riggs, Marie K., Matt R. Bohm, and Philip J. Mountain. "Examining Relationships Between Device Complexity and Failure Modes of Minimally Invasive Surgical Staplers." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66750.

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Minimally invasive surgery (MIS) has become the standard approach for an increasing number and variety of procedures. Designing devices for such surgeries presents many challenges and must address efficiency, accuracy, and ease of use. The complexity of a device’s design likely influences its performance in real life situations. Therefore, identifying the complexity and potential for failures of a device is crucial in the early stage of design in order to ensure the effectiveness and safety of the final product. A complexity measure is explored utilizing design variables such as the maximum number of connections, number of total elements, and number of unique elements within a device. Reverse engineering of medical devices has been completed to begin understanding such complexity variables. The overall objective of this research is to determine the correlation between a medical device’s complexity measure and its failure modes. The nature and frequency of problems associated with various surgical medical devices must be characterized. This paper is an initial investigation and focuses on surgical stapling devices for MIS. The analysis pertains strictly to surgical staplers that simultaneously staple and transect tissue with a design that allows insertion through small incisions via a trocar, wound protector and retractor, or direct insertion. Adverse event reports involving minimally invasive surgical staplers have been retrieved from the U.S. Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database from January 2006 – January 2016 and examined to determine trends in the characterization of device problems and prevalence of such problems. A total of 13,312 reports are included in the analysis. 106 events resulted in death, 3234 resulted in injury, and 9972 involved a device malfunction. A yearly analysis has been conducted analyzing the trends in event type (death, injury, and malfunction) and device brands involved in the reports over the past decade. A sample of reports was taken in order to perform a detailed analysis of the event descriptions. The reports are categorized by phase and description of failure modes associated with surgical stapler use. The phases of use in which failures occur have been identified as packaging, reload, articulation, application, firing, cutting, removal, and staple line. FDA recall information associated with these devices was also investigated. An extensive study regarding adverse events reported to the FDA associated with surgical staplers has not been completed since 2004 to the authors’ knowledge, nor a study investigating this specific category of surgical stapling devices. These devices are constantly evolving in regards to their design features, and their application is expanding to more wideranging open and MIS procedures. Despite the prevalence of minimally invasive surgical stapler use, any incident of failure may put a patient’s health and safety at risk. Malformed staples as a result of the firing phase, removal issues, and leaking staple lines were the main contributors to surgical stapler failure in the adverse event reports analyzed. Bariatric and thoracic surgery accounted for the majority of procedure types identified within the reports. The range of procedures in the analysis verifies the expansion of surgical stapler use and application. Various failure modes can be attributed to user error; however, the FDA recall information associated with these devices indicates that device failure shares responsibility. The results of this work contribute to the awareness of both surgical stapling device designers and users, and the importance of such must be heavily emphasized in order to prevent future complications in the field.
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"Evaluating economic relationships of stapled and traditional Australian REITs." In 19th International Congress on Modelling and Simulation. Modelling and Simulation Society of Australia and New Zealand (MSSANZ), Inc., 2011. http://dx.doi.org/10.36334/modsim.2011.d6.yong.

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Zhang, Peiyu, and Andrew Wilson. "Discovery of Stapled Peptides as Efficient BCL-xL Inhibitors." In 36th European Peptide Symposium. The European Peptide Society, 2022. http://dx.doi.org/10.17952/36eps/36eps.2022.101.

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Speltz, Thomas E., Jeanne M. Danes, Sean W. Fanning, Christopher G. Mayne, Emad Tajkhorshid, Geoffrey L. Greene, Jonna M. Frasor, and Terry W. Moore. "Abstract 1810: Stapled peptide inhibitors of mutant estrogen receptor/coactivator interactions." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1810.

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Braun, Craig R., Julian Mintseris, Evripidis Gavathiotis, Gregory H. Bird, Steven P. Gygi, and Loren D. Walensky. "Abstract LB-241: Photoreactive stapled peptides for target discovery in cancer." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-241.

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Leshchiner, Elizaveta, Joseph Bellairs, Gregory H. Bird, Kwadwo Opoku-Nsiah, Marina Godes, and Lored D. Walensky. "Abstract 2597: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2597.

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Bruno, Benjamin J., Sean P. Cornillie, Thomas E. Cheatham, Daniel H. Chou, and Carol S. Lim. "Abstract 3817: Recombinant stapled proteins for the treatment of chronic myeloid leukemia." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3817.

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Reports on the topic "Stapled"

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Seybold, Patricia. Staples. Boston, MA: Patricia Seybold Group, June 2006. http://dx.doi.org/10.1571/cs6-8-06cc.

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Research Institute (IFPRI), International Food Policy. Land productivity for staple food crops. Washington, DC: International Food Policy Research Institute, 2014. http://dx.doi.org/10.2499/9780896298460_14.

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Droller, Federico, and Martin Fiszbein. Staple Products, Linkages, and Development: Evidence from Argentina. Cambridge, MA: National Bureau of Economic Research, June 2019. http://dx.doi.org/10.3386/w25992.

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Marshak, Ronni. How Well Does Staples Help a Small Company "Manage My Stuff?". Boston, MA: Patricia Seybold Group, July 2011. http://dx.doi.org/10.1571/cea07-21-11cc.

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Bohorquez-Penuela, Camilo, and Mariana Urbina-Ramirez. Rising Staple Prices and Food Insecurity: The Case of the Mexican Tortilla. Banco de la República de Colombia, November 2020. http://dx.doi.org/10.32468/be.1144.

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We study the relationship between rising prices of tortillas---the Mexican staple par excellence---and household food insecurity between 2008 and 2014, a period in which global food prices experienced dramatic increases. The use of a unique combination of household-level data and official state-level information on prices allows us exploit signi cant variation in prices across the Mexican states. Since households cannot be tracked across time, we follow Deaton (1985) by constructing a series of pseudo-panels to control for time- invariant unobserved heterogeneity and measurement error. The regression estimates suggest that increasing tortilla prices affected food insecurity rates in Mexico. More speci cally, households with children or those in the second or third income quintile are more likely to be affected.
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Silvis, Huib, Raymond Schrijver, and Allard Jellema. Stapelen van beloningen voor natuurinclusieve landbouw : een lonkend perspectief? Wageningen: Wageningen Economic Research, 2022. http://dx.doi.org/10.18174/573120.

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Mehta, Parvez, Mitchell Driggers, and Carole Winterhalter. Development of Flame Resistant Combat Uniform Fabrics Made from Long Staple Wool and Aramid Blend Yarn. Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada578994.

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Smith, Joshua E. Orion Staples of C-IIAC Wins the 2017 American Chemical Society Division of Inorganic Chemistry Undergraduate Research Award. Office of Scientific and Technical Information (OSTI), May 2018. http://dx.doi.org/10.2172/1438100.

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Papadopoulos, Ioannis. STAPL-RTS: A runtime system for massive parallelism. Office of Scientific and Technical Information (OSTI), May 2016. http://dx.doi.org/10.2172/1492943.

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Mairo, Amy, and Mardik Leopold. Stapels bruinvissen! Hoe verhoudt een snelle massa-sectie zich tot het lopende dieet-onderzoek? Den Helder: Wageningen Marine Research, 2018. http://dx.doi.org/10.18174/448545.

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