Relevant bibliographies by topics / Stage migration / Journal articles

Journal articles on the topic 'Stage migration'

To see the other types of publications on this topic, follow the link: Stage migration.
Author: Grafiati
Published: 4 June 2021
Last updated: 20 February 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Stage migration.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Larner, Ken, and Craig Beasley. "Cascaded migrations: Improving the accuracy of finite‐difference migration." GEOPHYSICS 52, no. 5 (May 1987): 618–43. http://dx.doi.org/10.1190/1.1442331.

Full text
Abstract:
The accuracy of time migrations done with finite‐difference schemes deteriorates with increasing reflector dip. Some properties of migration in general, and of finite‐difference approaches in particular, suggest a way of improving the accuracy of finite‐difference schemes for migrating steep dips. First, although data will be undermigrated when too low a velocity is used in migration, a correctly migrated result can be obtained by migrating again, this time with the previously undermigrated result as input. In fact, a sequence of undermigrations will yield the correct result as long as the sum of the squares of the migration velocities used in the different migration stages equals the square of the correct migration velocity. A second property is that the apparent spatial dip of a reflector perceived by the migration process is a function of not only the time dip of the unmigrated reflection, but also the velocity used in the migration. In a sequence of low‐velocity migrations, the apparent spatial dip perceived at each migration stage can be considerably less than the true dip. Thus, because finite‐difference migration is accurate for small spatial dips, the cascaded migrations yield a more accurate result than that of single‐stage migration. Also, because each migration stage is done with low velocity, the depth step can be large; hence, the computational effort need not be. The accuracy of the method is not compromised (in fact, it improves) in media in which velocity increases with depth. Moreover, the cascaded approach suffers no more than other methods of time migration where velocity varies mildly in the lateral direction. In applications of the method to stacked data from the Gulf of Mexico, reflections from near‐vertical flanks of salt domes were migrated with accuracy comparable to that achieved by frequency‐wavenumber domain migration.
APA, Harvard, Vancouver, ISO, and other styles
2

Kane, Christopher J., Katherine Mallin, Jamie Ritchey, Matthew R. Cooperberg, and Peter R. Carroll. "Renal cell cancer stage migration." Cancer 113, no. 1 (July 1, 2008): 78–83. http://dx.doi.org/10.1002/cncr.23518.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Beasley, Craig J., Walt Lynn, Ken Larner, and Hung Nguyen. "Cascaded f-k migration: Removing the restrictions on depth‐varying velocity." GEOPHYSICS 53, no. 7 (July 1988): 881–93. http://dx.doi.org/10.1190/1.1442525.

Full text
Abstract:
Stolt’s frequency‐wavenumber (f-k) method is computationally efficient and has unlimited dip accuracy for constant‐velocity media. Although the f-k method can handle moderate vertical velocity variations, errors become unacceptable for steep dips when such variations are large. This paper describes an extension to the f-k method that removes its restrictions on vertical velocity variation, yielding accuracy comparable to phase‐shift migration at only a fraction of the computational time. This extension of the f-k method is based on partitioning the velocity field, just as in cascaded finite‐difference migration, and performing a number of stages of f-k migration. In each stage, the migration‐velocity field is closer to a constant—the ideal situation for the f-k migration method—than when the migration is done conventionally (i.e., in just one stage). Empirical results and error analyses show that, at most, four stages of the cascaded f-k algorithm are sufficient to migrate steep events as accurately as by the phase‐shift method for virtually any vertically inhomogeneous velocity field. Given its accuracy and efficiency, cascaded f-k migration can become the method of choice for 2-D, two‐pass 3-D, and single‐pass 3-D time migrations.
APA, Harvard, Vancouver, ISO, and other styles
4

Li, Shiyong, Yue Zhang, and Wei Sun. "Optimal Resource Allocation Model and Algorithm for Elastic Enterprise Applications Migration to the Cloud." Mathematics 7, no. 10 (October 1, 2019): 909. http://dx.doi.org/10.3390/math7100909.

Full text
Abstract:
Cloud computing has been widely used in various industries in recent years. However, when migrating enterprise applications into the cloud, enterprise users face a problem with minimizing migration time and cloud resource providers face a dilemma of resource allocation problem, with the objective of maximizing the migration utility of enterprise users while minimizing the cost of cloud resource providers. In order to achieve them, this paper considered cloud migration objectives including cloud migration time, cloud migration utility, and cloud data center cost, and proposed a resource allocation model for enterprise applications migration into the cloud. The model is divided into two stages: the bandwidth allocation for enterprise applications migration to the cloud and the physical resource allocation of cloud resource providers for enterprise applications deployment into the cloud. In the first stage, we aim to minimize the cloud migration time for enterprise applications, and propose a scheme of bandwidth allocation for each component of applications. In the second stage, we present the resource allocation of cloud resource providers and propose a gradient-based algorithm which can achieve optimal resource allocation. Finally, we give some numerical simulation results to illustrate the performance of the proposed algorithm.
APA, Harvard, Vancouver, ISO, and other styles
5

VanderWalde, Noam Avraham, Ramzi George Salloum, Tsai-Ling Liu, Mark Christopher Hornbrook, Maureen Cecelia O'Keeffe-Rosetti, Debra Pearson Ritzwoller, Paul Arthur Fishman, Jennifer Elston Lafata, Amir H. Khandani, and Bhishamjit S. Chera. "Positron emission tomography and stage migration for head and neck cancer." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 6018. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.6018.

Full text
Abstract:
6018 Background: Positron emission tomography (PET) is often used for the staging of head and neck cancer (HNC). The purpose of this study is to explore the association between the increased utilization of PET and stage/survival in the managed care environment. Methods: Adult patients diagnosed with HNC (n=958) between 2000-2008, at 4 integrated health systems (Group Health Cooperative, Seattle; Health Alliance Plan/Henry Ford Health System, Detroit; Kaiser Permanente Colorado and Northwest, Portland) were identified via tumor registries linked to claims data. We compared AJCC stage distribution, patient/treatment characteristics, and survival between pre-PET era (2000-2004) vs. PET era (2005-2008), and those with PET vs. those without, during the PET era. AJCC stage was grouped into stage I/II (localized), stage III/IVa/IVb (locally advanced), and stage IVc (metastatic). Ordered logistic regression estimated the effects of PET utilization on upstaging. Kaplan-Meier estimates described overall survival (OS) differences between PET users and nonusers in the PET era. Cox proportional hazards regression evaluated the effect of PET use on survival. Results: There was a non-significant increase in stage III/IVa/IVb (40% to 44%) with a decrease in stage I/II (58% to 52%) between pre-PET era and PET era (p=0.11). During the PET era, patients with PET were more likely stage III/IVa/IVb and less likely stage I/II compared to patients without PET (III/IVa/IVb: 62% vs. 29%, I/II: 35% vs. 68%). On multivariate analysis those who were staged with PET were twice as likely to have locally advanced disease (OR 2.091; p=0.006). There was no difference in stage IVc. Patients with PET scans were more likely to receive chemotherapy with radiation and less likely to receive no treatment. 3-year actuarial OS for patients (all stages) with and without PET was 81% vs. 77% (p=0.261). 3-year actuarial OS for patients staged III/IVa/IVb with and without PET was 58% vs. 41% (p= 0.001). Conclusions: HNC patients were more likely to be upstaged with the use of PET. There was an improvement in survival in stage III/IVa/IVb patients, but no difference in survival across all stages. This likely reflects selection bias and stage migration rather than improved outcomes among individual patients.
APA, Harvard, Vancouver, ISO, and other styles
6

Flory, Andrea B., Kenneth M. Rassnick, Tracy Stokol, Peter V. Scrivani, and Hollis N. Erb. "Stage Migration in Dogs with Lymphoma." Journal of Veterinary Internal Medicine 21, no. 5 (September 2007): 1041–47. http://dx.doi.org/10.1111/j.1939-1676.2007.tb03062.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Horvath, L., R. Thanigasalam, K. Rasiah, P. Stricker, A. Earnest, A. Haynes, S. Sutherland, R. Sutherland, and S. Henshall. "Stage migration and the Kattan nomogram." Journal of Clinical Oncology 26, no. 15_suppl (May 20, 2008): 5162. http://dx.doi.org/10.1200/jco.2008.26.15_suppl.5162.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Sun, Da Zhi, Xu Qian Li, and Xiao Feng Pan. "Migration Distribution Features of Phenanthrene in Aquifer." Advanced Materials Research 113-116 (June 2010): 2362–67. http://dx.doi.org/10.4028/www.scientific.net/amr.113-116.2362.

Full text
Abstract:
The spatial and temporal distribution of phenanthrene were examined with indoor simulation experiments to study the transportation and transformation of phenathrene in the groundwater aquifer. The result showed that non-point pollution of PAHs is easily formed because of the effects of PAHs pollution’s convection and dispersion along with groundwater. The experiment about relationship between pH, Eh, conductivity and pollution plume of phenathrene revealed that variation trend of pH and conductivity are the same. Yet Eh variation is just contrary as the average rising ratios were 0.194 mv/d and 0.163 mv/d, respectively. The natural attenuation of phenanthrene pollutants in aquifer is obvious for the initial 80 days. The three stages about variation of phenanthrene in groundwater aquifer were slow decline stage (stage I), rapid decline stage (stage II) and stationary stage (III stage). The removal rate of phenanthrene by aquifer is 37.2 %, which adapts to stage II concerning groundwater remediation.
APA, Harvard, Vancouver, ISO, and other styles
9

WILSON, G. R., and J. S. WATSON. "Migration of Silicone Rods." Journal of Hand Surgery 19, no. 2 (April 1994): 199–201. http://dx.doi.org/10.1016/0266-7681(94)90165-1.

Full text
Abstract:
Two cases of migration of silastic rods into the forearm after the first stage of flexor tendon grafting are reported. A CT scan shows the rods well if they are not visible on a plain X-ray. Possible factors involved in distal detachment of the rods are the composition of the tendon spacer, method of distal fixation, method of proximal fixation and the time between the stages of reconstruction.
APA, Harvard, Vancouver, ISO, and other styles
10

Epperlein, H. H., W. Halfter, and R. P. Tucker. "The distribution of fibronectin and tenascin along migratory pathways of the neural crest in the trunk of amphibian embryos." Development 103, no. 4 (August 1, 1988): 743–56. http://dx.doi.org/10.1242/dev.103.4.743.

Full text
Abstract:
It is generally assumed that in amphibian embryos neural crest cells migrate dorsally, where they form the mesenchyme of the dorsal fin, laterally (between somites and epidermis), where they give rise to pigment cells, and ventromedially (between somites and neural tube), where they form the elements of the peripheral nervous system. While there is agreement about the crest migratory routes in the axolotl (Ambystoma mexicanum), different opinions exist about the lateral pathway in Xenopus. We investigated neural crest cell migration in Xenopus (stages 23, 32, 35/36 and 41) using the X. laevis-X. borealis nuclear marker system and could not find evidence for cells migrating laterally. We have also used immunohistochemistry to study the distribution of the extracellular matrix (ECM) glycoproteins fibronectin (FN) and tenascin (TN), which have been implicated in directing neural crest cells during their migrations in avian and mammalian embryos, in the neural crest migratory pathways of Xenopus and the axolotl. In premigratory stages of the crest, both in Xenopus (stage 22) and the axolotl (stage 25), FN was found subepidermally and in extracellular spaces around the neural tube, notochord and somites. The staining was particularly intense in the dorsal part of the embryo, but it was also present along the visceral and parietal layers of the lateral plate mesoderm. TN, in contrast, was found only in the anterior trunk mesoderm in Xenopus; in the axolotl, it was absent. During neural crest cell migration in Xenopus (stages 25–33) and the axolotl (stages 28–35), anti-FN stained the ECM throughout the embryo, whereas anti-TN staining was limited to dorsal regions. There it was particularly intense medially, i.e. in the dorsal fin, around the neural tube, notochord, dorsal aorta and at the medial surface of the somites (stage 35 in both species). During postmigratory stages in Xenopus (stage 40), anti-FN staining was less intense than anti-TN staining. In culture, axolotl neural crest cells spread differently on FN- and TN-coated substrata. On TN, the onset of cellular outgrowth was delayed for about 1 day, but after 3 days the extent of outgrowth was indistinguishable from cultures grown on FN. However, neural crest cells in 3-day-old cultures were much more flattened on FN than on TN. We conclude that both FN and TN are present in the ECM that lines the neural crest migratory pathways of amphibian embryos at the time when the neural crest cells are actively migrating. FN is present in the embryonic ECM before the onset of neural crest migration.(ABSTRACT TRUNCATED AT 400 WORDS)
APA, Harvard, Vancouver, ISO, and other styles
11

M Quinn, Leonard, Adnan A Sheikh, Ayman Abdelrazeq, Nagarajan Pranesh, Mark J Tighe, and Barry A Taylor. "Stage Migration in Curative Colorectal Cancer Resections." Journal of Gastroenterology and Hepatology Research 4, no. 8 (2015): 1722–24. http://dx.doi.org/10.17554/j.issn.2224-3992.2015.04.479.

Full text
APA, Harvard, Vancouver, ISO, and other styles
12

Noldus, Joachim, Markus Graefen, Alexander Haese, Rolf-Peter Henke, Peter Hammerer, and Hartwig Huland. "Stage Migration in Clinically Localized Prostate Cancer." European Urology 38, no. 1 (2000): 74–78. http://dx.doi.org/10.1159/000020255.

Full text
APA, Harvard, Vancouver, ISO, and other styles
13

Dong, Fei, Alwyn M. Reuther, Cristina Magi-Galluzzi, Ming Zhou, Patrick A. Kupelian, and Eric A. Klein. "1886: Has PSA-Induced Stage Migration Ended?" Journal of Urology 177, no. 4S (April 2007): 627. http://dx.doi.org/10.1016/s0022-5347(18)32059-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Yang, S., J. Wu, and A. Christou. "Initial stage of silver electrochemical migration degradation." Microelectronics Reliability 46, no. 9-11 (September 2006): 1915–21. http://dx.doi.org/10.1016/j.microrel.2006.07.080.

Full text
APA, Harvard, Vancouver, ISO, and other styles
15

Bunt, A. M. G., J. Hermans, V. T. H. B. M. Smit, C. J. H. van de Velde, G. J. Fleuren, and J. A. Bruijn. "P70 Stage migration in a surgical trial." Controlled Clinical Trials 14, no. 5 (October 1993): 456. http://dx.doi.org/10.1016/0197-2456(93)90202-o.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Tubaro, Andrea. "Stage migration in clinically localized prostate cancer." Current Opinion in Urology 11, no. 2 (March 2001): 215. http://dx.doi.org/10.1097/00042307-200103000-00025.

Full text
APA, Harvard, Vancouver, ISO, and other styles
17

Quinn, L. M., A. A. Sheikh, S. Fields-Delaney, M. J. Tighe, and B. A. Taylor. "Stage migration in curative colorectal cancer resections." International Journal of Surgery 11, no. 8 (October 2013): 620. http://dx.doi.org/10.1016/j.ijsu.2013.06.177.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

SHELEP, Yuliia. "UKRAINIAN-POLISH MIGRATION PROCESSES: THE CURRENT STAGE." Ukraine-Poland: Historical Heritage and Public Consciousness 14 (2021): 177–93. http://dx.doi.org/10.33402//up.2021-14-177-193.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

Pan, Naide, and William S. French. "Generalized two‐pass three‐dimensional migration for imaging steep dips in vertically inhomogeneous media." GEOPHYSICS 54, no. 5 (May 1989): 544–54. http://dx.doi.org/10.1190/1.1442681.

Full text
Abstract:
Conventional two‐pass 3-D time migration is exactly equivalent to full 3-D time migration in a homogeneous medium. For vertically inhomogeneous media representing typical earth velocities, however, conventional two‐pass 3-D migration fails to correctly image dips beyond about 45 degrees. This failure is the result of an inherent velocity error incurred during the first pass of a two‐pass 3-D migration. For a vertically inhomogeneous medium, the theory of residual migration can be combined with the results for homogeneous media to derive a series of successive two‐pass migration stages which are equivalent to a full 3-D migration. Each stage of this generalized two‐pass 3-D migration is implemented using an appropriate constant migration velocity. In practice, the required number of two‐pass stages can be reduced to a computationally manageable few; and the I/O can be reduced by one‐third to one‐half of that required using a straightforward application of repeated two‐pass migrations. This procedure allows existing 2-D migration programs to be upgraded to steep‐dip 3-D migration programs by use of a simple I/O structure. Any of the basic 2-D migration algorithms can be used, but we have employed a 50-degree finite‐difference algorithm. In addition, generalized two‐pass 3-D migration overcomes the dip limitations of the underlying 2-D finite‐difference migration algorithm for the same reasons that cascaded 2-D migration extends the dip range of 2-D migration algorithms. Synthetic data examples clearly show the success of this method in imaging steep dips in vertically inhomogeneous media.
APA, Harvard, Vancouver, ISO, and other styles
20

Privara, Andrej, and Eva Rievajova. "Migration Challenges of the Current Stage of Globalization." SHS Web of Conferences 92 (2021): 07054. http://dx.doi.org/10.1051/shsconf/20219207054.

Full text
Abstract:
Research background: International labor migration is much less globalized than the other components of this process, mainly due to the various restrictions it continually encounters. Usually, the globalization of international migration results in complex migration systems. The migration challenges of the current stage of globalization include, among other things, changes in the categories of present migrants. The profile of migrants is becoming more and more diversified. It comprises women, minors, skilled people, entrepreneurs, and a low-skilled workforce or one who accepts a strong degree of disqualification. Purpose of the article: The purpose of the paper is to identify processes of labor migration in the conditions of globalization, to analyze changes in the characteristics of migrants, as well as the paradox of complementarity between migration and globalization. Methods: The authors used the methods of theoretical and empirical analysis. In addition to standard methods of theoretical analysis, they also used content analysis of text documents, mostly of an official nature. These were mainly national and European papers dealing with the issue of international labor migration in the context of globalization. Empirical research is based on the analysis of official data obtained from databases of international institutions (Eurostat, OECD, IOM, etc.). Findings & Value added: As a result of the analysis, the authors concluded about adequate European immigration policy and greater labor mobility would contribute to addressing labor market imbalances. At the end of the article, the authors also formulated specific measures to support mobility within the EU.
APA, Harvard, Vancouver, ISO, and other styles
21

LIU, HONGJUN, and MING C. LEU. "LIQUID PHASE MIGRATION IN EXTRUSION OF AQUEOUS ALUMINA PASTE FOR FREEZE-FORM EXTRUSION FABRICATION." International Journal of Modern Physics B 23, no. 06n07 (March 20, 2009): 1861–66. http://dx.doi.org/10.1142/s0217979209061743.

Full text
Abstract:
Freeze-form Extrusion Fabrication (FEF) is an additive manufacturing technique that extrudes highly ceramic loaded aqueous paste along 3D contours for complex ceramic part fabrication. The phenomenon of liquid phase migration (LPM) in paste extrusion process will result in variation of liquid content in paste and consequently problems in processing and non-uniform properties of ceramic parts. It is necessary to understand the LPM phenomenon in FEF process. In this paper, the effect of liquid phase migration on extrusion of aqueous alumina paste was investigated for FEF process. The water content and extrusion force data were collected for a series of ram velocities. According to the extrusion force profiles, the extrusion process can be divided into four stages: compaction stage, transient stage, steady stage and dead zone stage. The results show that ram velocity is the key parameter for occurrence of liquid phase migration phenomenon and there is a velocity threshold above which the liquid phase migration will not happen.
APA, Harvard, Vancouver, ISO, and other styles
22

Bhattacharyya, A., R. Brackenbury, and N. Ratner. "Axons arrest the migration of Schwann cell precursors." Development 120, no. 6 (June 1, 1994): 1411–20. http://dx.doi.org/10.1242/dev.120.6.1411.

Full text
Abstract:
The neural crest gives rise to a variety of cell types including Schwann cells of the peripheral nervous system. Schwann cell precursors begin to differentiate early and migrate along specific pathways in the embryo before associating with nerve trunks. To determine whether motor axons direct the migration of Schwann cell precursors along specific pathways, we tested the effect of ablating the ventral half of the neural tube, which contains motor neuron cell bodies. The ventral neural tube was removed unilaterally from lumbar regions of chicken embryos at stage 17, when neural crest cells are just beginning to migrate and before motor axons have extended out of the neural tube. At several stages after ventral tube ablation, sections of the lumbar region of these embryos were stained with anti-acetylated tubulin to label developing axons, HNK-1 to label migrating neural crest cells and 1E8 to label Schwann cell precursors. In many embryos the ablation of motor neurons was incomplete. The staining patterns in these embryos support the idea that some Schwann cells are derived from the neural tube. In embryos with complete motor neuron ablation, at stage 18, HNK-1-positive neural crest cells had migrated to normal locations in both control and ablated sides of the embryo, suggesting that motor axons or the ventral neural tube are not required for proper migration of neural crest cells. However, by stage 19, cells that were positive for HNK-1 or 1E8 were no longer seen in the region of the ventral root, nor ventral to the ventral root region. Because Schwann cell precursors require neural-derived factors for their survival in vitro, we tested whether neural crest cells that migrate to the region of the ventral root in ventral neural tube-ablated embryos then die. Nile Blue staining for dead and dying cells in ventral neural tube-ablated embryos provided no evidence for cell death at stage 18. These results suggest that motor axons arrest the migration of Schwann cell precursors during neural crest migration.
APA, Harvard, Vancouver, ISO, and other styles
23

Bahdi, Firas, Rollin George, Kavea Paneerselvam, Dang Nguyen, Wasif M. Abidi, Mohamed O. Othman, and Isaac Raijman. "Comparison of endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography outcomes using various technical approaches." Endoscopy International Open 10, no. 04 (April 2022): E459—E467. http://dx.doi.org/10.1055/a-1783-9564.

Full text
Abstract:
Abstract Background and study aims Roux-en-Y gastric bypass presents an anatomic challenge for patients needing ERCP. EUS-directed transgastric ERCP (EDGE) offers high clinical success but carries considerable risk of adverse events (AEs) with no standardized technical approach. In our study, we review the safety and efficacy of our various EDGE technical approaches. Patients and methods A retrospective single-center study of all patients who underwent EDGE procedures between February 2018 and November 2019. Primary outcomes included comparing the technical and clinical success, AEs, and lumen-apposing metal stent (LAMS) migration rates per access route (gastrogastric vs jejuno-gastric), number of procedure stages (single-stage vs two-stage), and stent size (15 mm vs 20 mm). Secondary outcomes included LAMS migration characteristics and management. Results Thirty-two EDGE procedures were performed in 29 patients, including 17 single-stage and 15 two-stage procedures, 23 gastrogastric, and nine jejuno-gastric routes, fourteen 15-mm and 17 20-mm LAMS. Overall technical and clinical success rates were 96.9 % and 87.1 %, respectively, without any significant difference between groups. The overall AE rate was (34.4 %) and was significantly lower in the 20-mm LAMS group compared to the 15-mm group (17.6 % vs 57.1 %, P = 0.03). Compared to two-stage procedures, there was no significant difference in AEs with single-stage procedures (35.3 % vs 33.3 %, P = 0.33). The LAMS migration rate was (25 %) with no significant difference between groups. Most migrations were around the index procedure and managed endoscopically (62.5 %). Conclusions EDGE offers high clinical success rates but AE rates remain significant. In our series, a 20-mm LAMS resulted in a significantly lower AE rate than the 15-mm LAMS. Large multicenter studies are recommended to identify technical factors leading to an optimal EDGE procedure.
APA, Harvard, Vancouver, ISO, and other styles
24

Stockton, Rebecca A., and Bruce S. Jacobson. "Modulation of Cell-Substrate Adhesion by Arachidonic Acid: Lipoxygenase Regulates Cell Spreading and ERK1/2-inducible Cyclooxygenase Regulates Cell Migration in NIH-3T3 Fibroblasts." Molecular Biology of the Cell 12, no. 7 (July 2001): 1937–56. http://dx.doi.org/10.1091/mbc.12.7.1937.

Full text
Abstract:
Adhesion of cells to an extracellular matrix is characterized by several discrete morphological and functional stages beginning with cell-substrate attachment, followed by cell spreading, migration, and immobilization. We find that although arachidonic acid release is rate-limiting in the overall process of adhesion, its oxidation by lipoxygenase and cyclooxygenases regulates, respectively, the cell spreading and cell migration stages. During the adhesion of NIH-3T3 cells to fibronectin, two functionally and kinetically distinct phases of arachidonic acid release take place. An initial transient arachidonate release occurs during cell attachment to fibronectin, and is sufficient to signal the cell spreading stage after its oxidation by 5-lipoxygenase to leukotrienes. A later sustained arachidonate release occurs during and after spreading, and signals the subsequent migration stage through its oxidation to prostaglandins by newly synthesized cyclooxygenase-2. In signaling migration, constitutively expressed cyclooxygenase-1 appears to contribute ∼25% of prostaglandins synthesized compared with the inducible cyclooxygenase-2. Both the second sustained arachidonate release, and cyclooxygenase-2 protein induction and synthesis, appear to be regulated by the mitogen-activated protein kinase extracellular signal-regulated kinase (ERK)1/2. The initial cell attachment-induced transient arachidonic acid release that signals spreading through lipoxygenase oxidation is not sensitive to ERK1/2 inhibition by PD98059, whereas PD98059 produces both a reduction in the larger second arachidonate release and a blockade of induced cyclooxygenase-2 protein expression with concomitant reduction of prostaglandin synthesis. The second arachidonate release, and cyclooxygenase-2 expression and activity, both appear to be required for cell migration but not for the preceding stages of attachment and spreading. These data suggest a bifurcation in the arachidonic acid adhesion-signaling pathway, wherein lipoxygenase oxidation generates leukotriene metabolites regulating the spreading stage of cell adhesion, whereas ERK 1/2-induced cyclooxygenase synthesis results in oxidation of a later release, generating prostaglandin metabolites regulating the later migration stage.
APA, Harvard, Vancouver, ISO, and other styles
25

Porthouse, Kristina H., Sharon R. Chirgwin, Sharon U. Coleman, H. Wayne Taylor, and Thomas R. Klei. "Inflammatory Responses to Migrating Brugia pahangi Third-Stage Larvae." Infection and Immunity 74, no. 4 (April 2006): 2366–72. http://dx.doi.org/10.1128/iai.74.4.2366-2372.2006.

Full text
Abstract:
ABSTRACT Despite being central to parasite establishment and subsequent host pathological and immunologic responses, host-parasite interactions during early third-stage filarial larva (L3) migration are poorly understood. These studies aimed to define early tissue migration of Brugia pahangi L3 in the gerbil (Meriones unguiculatus) and measure host cellular responses during this period. Gerbils were intradermally inoculated in the hind limb with 100 B. pahangi L3, and necropsies were performed at various times. At 3 h, most L3 (96.3%) were recovered from tissues associated with the infection site, with marked L3 migration occurring by 24 h. Larvae were dispersed throughout the lymphatics at 7 days postinfection (dpi), and at 28 dpi, most parasites were recovered from the spermatic cord lymphatics. Parasites were identified histologically at all time points. Inflammatory cells, primarily neutrophils, were frequently observed around larvae in the dermis and muscle near the injection site at 3 h and 24 h. Levels of interleukin-6 (IL-6) and tumor necrosis factor-α mRNA peaked at 3 h in all tissues, with IL-6 levels also high in the spleen at 28 dpi. Levels of IL-4 mRNA were elevated in all tissues at 28 dpi. These observations demonstrate that L3 migrate quickly through various tissues and into lymph nodes in a predictable pattern. Migrating L3 induce an early acute inflammatory response that is modulated as parasites establish in the lymphatics. Polarization of the host response towards a dominant Th2-like profile is present at 7 dpi and is well established by 28 dpi in this permissive host.
APA, Harvard, Vancouver, ISO, and other styles
26

Yacubova, Elina, and Hitoshi Komuro. "Stage-specific control of neuronal migration by somatostatin." Nature 415, no. 6867 (January 2002): 77–81. http://dx.doi.org/10.1038/415077a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

LoTurco, Joseph J., and Jilin Bai. "The multipolar stage and disruptions in neuronal migration." Trends in Neurosciences 29, no. 7 (July 2006): 407–13. http://dx.doi.org/10.1016/j.tins.2006.05.006.

Full text
APA, Harvard, Vancouver, ISO, and other styles
28

Rostovskaya, T. K., and V. I. Skorobogatova. "Challenges of Educational Migration at the Present Stage." University Management: Practice and Analysis 26, no. 2 (October 25, 2022): 105–13. http://dx.doi.org/10.15826/umpa.2022.02.016.

Full text
Abstract:
According to the Federal Project «Russia is an attractive country for studying and working», by 2030 the number of foreign students should increase by 1.5 times compared to 2021. In recent years, higher education educational institutions of higher education have made significant progress in attracting foreign students on average, their annual growth in the number of foreign students in Russian universities in during the last previous three years has beenbeing about 6 % per year. The attraction ofAttracting foreign students in recent years has been associated with serious challenges: the pandemic and quarantine restrictions (2020–2021), the forced transition of universities to distance learning (2020– 2022), the transformation of the geopolitical situation, the allocation of the category of unfriendly countries, the rejection of the Bologna format of the organization of the educational process organization. These factors have also left their mark oninfluenced the admission campaign of the 2022–2023 academic year. The authors of the articlethis paper aim to at identifying the key problems of internationalization of education internationalization in modern conditions. We propose fundamentally new managerial and legal solutions for the development of educational migration developmentat a qualitatively new level. The empirical basis of the study was a university international services employees’ survey of employees of international services ofpoll universities and the official statistics of international and Russian organizations. The main research methods are formal legal and comparative legal. The article may be useful tomight be of use for the employees of educational authorities, uni versity management, employees and of university international services of educational institutions of higher education, for university managers, and for international education experts in the field of international education.
APA, Harvard, Vancouver, ISO, and other styles
29

MARUYAMA, H., A. NISHIMAKI, Y. TAKUMA, M. KURIMOTO, T. SUZUKI, Y. SAKATOKU, M. ISHIKAWA, and N. OHTA. "Successive changes in tissue migration capacity of developing larvae of an intestinal nematode,Strongyloides venezuelensis." Parasitology 132, no. 3 (November 9, 2005): 411–18. http://dx.doi.org/10.1017/s0031182005009042.

Full text
Abstract:
Infective larvae of an intestinal nematode,Strongyloides venezuelensis, enter rodent hosts percutaneously, and migrate through connective tissues and lungs. Then they arrive at the small intestine, where they reach maturity. It is not known howS. venezuelensislarvae develop during tissue migration. Here we demonstrate that tissue invasion ability ofS. venezuelensislarvae changes drastically during tissue migration, and that the changes are associated with stage-specific protein expression. Infective larvae, connective tissue larvae, lung larvae, and mucosal larvae were used to infect mice by various infection methods, including percutaneous, subcutaneous, oral, and intraduodenal inoculation. Among different migration stages, only infective larvae penetrated mouse skin. Larvae, once inside the host, quickly lost skin penetration ability, which was associated with the disappearance of an infective larva-specific metalloprotease. Migrating larvae had connective tissue migration ability until in the lungs, where larvae became able to settle down in the intestinal mucosa. Lung larvae and mucosal larvae were capable of producing and secreting adhesion molecules.
APA, Harvard, Vancouver, ISO, and other styles
30

Łobodzińska, Anna. "Polki w Norwegii – decyzje i plany prokreacyjne." Studia Demograficzne, no. 1(169) (June 10, 2016): 39–63. http://dx.doi.org/10.33119/sd.2016.1.2.

Full text
Abstract:
Given the scale and pace of post-EU accession migrations from Poland, as well as age and gender structure of their participants, an increased interest in family behaviour and intentions of this group has been recently noted. The observed interrelations between migration and family building processes are multidimensional. Thus, this study aims to investigate interrelations between migration, childbearing decisions and intentions of Polish female migrants in Norway. The paper is based on a survey research conducted among Polish female migrants in 2014–2015. The results show that majority of immigrants was childless upon arrival. For those, who had a child before migration, the mobility occurred in a relatively early stage of family formation process. However, a concentration of births shortly after migration can be observed. This concerns mostly women migrating to join their husbands or partners. An opposite evidence is observed regarding respondents who had one child upon arrival to Norway – only few of them proceeded to the second birth. Almost 58% of respondents wants to give birth to their next child in Norway. More importantly, majority of women planning a long-term stay in Norway still has positive or uncertain childbearing intentions.
APA, Harvard, Vancouver, ISO, and other styles
31

Aggoune, Aicha, and Mohamed Sofiane Namoune. "P3 Process for Object-Relational Data Migration to NoSQL Document-Oriented Datastore." International Journal of Software Science and Computational Intelligence 14, no. 1 (January 1, 2022): 1–20. http://dx.doi.org/10.4018/ijssci.309994.

Full text
Abstract:
The exponential growth of complex data in object-relational databases (ORDB) raises the need for efficient storage with scalability, consistency, and partition tolerance. The migration towards NoSQL (not only structured query language) datastores is the best fit for distributed complex data. Unfortunately, very few studies provide solutions for ORDB migration to NoSQL. This paper reports on how to achieve the migration of complex data from ORDB to a document-oriented NoSQL database. The proposed approach focused on the P3 process that involves three major stages: (P1) the preprocessing stage to access and extract the database features using SQL queries, (P2) the processing stage to provide the data mapping by using a list of mapping rules between the source and target models, and (P3) the post-processing stage to store and request the migrated data within the NoSQL context. A thorough experiments on two real-life databases veriðes the P3 process improves the performance of data migration with complex schema structures.
APA, Harvard, Vancouver, ISO, and other styles
32

Didkivska, Lesia. "Migration of Ukrainians at the pre-industrial stage of social development." Ìstorìâ narodnogo gospodarstva ta ekonomìčnoï dumki Ukraïni 2019, no. 52 (2019): 138–54. http://dx.doi.org/10.15407/ingedu2019.52.138.

Full text
Abstract:
The subject of the research is the migration history of Ukrainians at the pre-industrial stage of social development. The purpose of the article is the historical and economic analysis of migration trends and the identification of geographical vectors of the first migration flows on Ukrainian lands and the institutional factors and socioeconomic consequences of the spread of migration sentiment among the population during the period. The result of the study is the identification of features of the first migration flows in the Ukrainian territory, the classification of migration according to its causes, the identification of directions of the resettlement of Ukrainians and the consequences of emigration of Ukrainians. It was revealed that the labour migration of Ukrainians was preceded by political migration related to the regular attacks of Tatars and Turks, the fall of Kievan Rus, the loss of national statehood, the colonization of Ukrainian lands by foreign states. In spite of a number of negative consequences, the Ukrainian people received both economic benefits and qualitative progress in state-building. At the same time, labour migration led to the irreversible loss of the economically active working population, above all the peasantry, who were the most important group among Ukrainian emigrants. The main factors contributing to the labour migration of Ukrainians were similar: institutional (abolition of serfdom), demographic (reduction of mortality rate, while maintaining high fertility), socio-economic (low-income Ukrainian peasants, mass impoverishment and low standards of living), innovative infrastructure (development of the newest means of communication and large geographical discoveries) that encouraged intercountry resettlement. However, the vector of migratory flows of Ukrainians was rather diverse: Ukrainians under Austro-Hungary (Galicia, Northern Bukovina and Transcarpathian Ukraine) were covered by intercontinental migration (USA, Canada, Brazil and Argentina), while the peasants of the Left Bank and Central Ukraine migrated to the Northern Caucasus and the Far East.
APA, Harvard, Vancouver, ISO, and other styles
33

Anna Mähönen, Tuuli, and Inga Jasinskaja-Lahti. "Anticipated and Perceived Intergroup Relations as Predictors of Immigrants’ Identification Patterns." European Psychologist 17, no. 2 (January 2012): 120–30. http://dx.doi.org/10.1027/1016-9040/a000114.

Full text
Abstract:
The present study among Ingrian-Finnish remigrants (N = 153) from Russia to Finland examined the effects of anticipated discrimination in the pre-migration stage on the way intergroup relations are perceived and multiple cultural identities are formed in the post-migration stage. First, the results indicated that anticipated discrimination in the pre-migration stage affected perceived discrimination, permeability of group boundaries, and group status legitimacy in the post-migration stage. Second, anticipated discrimination in the pre-migration stage was not directly associated with any of the identities in the post-migration stage, but it was indirectly associated with national identification, via perceived discrimination and permeability of group boundaries. Perceived discrimination and impermeability of group boundaries in the post-migration stage were associated with lower levels of remigrants’ national (Finnish) identification in the new homeland. Third, the perceived legitimacy of Ingrian-Finns’ low status was associated with increased Russian minority identification. The findings extend previous research on the effects of anticipated intergroup contact on actual intergroup encounters on the one hand, and on the effects of perceived discrimination, status legitimacy, and permeability of group boundaries on national and ethnic identification among immigrants, on the other.
APA, Harvard, Vancouver, ISO, and other styles
34

Jack, Chandra N., Neil Buttery, Boahemaa Adu-Oppong, Michael Powers, Christopher R. L. Thompson, David C. Queller, and Joan E. Strassmann. "Migration in the social stage ofDictyostelium discoideumamoebae impacts competition." PeerJ 3 (October 22, 2015): e1352. http://dx.doi.org/10.7717/peerj.1352.

Full text
Abstract:
Interaction conditions can change the balance of cooperation and conflict in multicellular groups. After aggregating together, cells of the social amoebaDictyostelium discoideummay migrate as a group (known as a slug) to a new location. We consider this migration stage as an arena for social competition and conflict because the cells in the slug may not be from a genetically homogeneous population. In this study, we examined the interplay of two seemingly diametric actions, the solitary action of kin recognition and the collective action of slug migration inD. discoideum, to more fully understand the effects of social competition on fitness over the entire lifecycle. We compare slugs composed of either genetically homogenous or heterogeneous cells that have migrated or remained stationary in the social stage of the social amoebaDictyostelium discoideum. After migration of chimeric slugs, we found that facultative cheating is reduced, where facultative cheating is defined as greater contribution to spore relative to stalk than found for that clone in the clonal state. In addition our results support previous findings that competitive interactions in chimeras diminish slug migration distance. Furthermore, fruiting bodies have shorter stalks after migration, even accounting for cell numbers at that time. Taken together, these results show that migration can alleviate the conflict of interests in heterogeneous slugs. It aligns their interest in finding a more advantageous place for dispersal, where shorter stalks suffice, which leads to a decrease in cheating behavior.
APA, Harvard, Vancouver, ISO, and other styles
35

Shutaleva, Anna, Nikita Martyushev, Alexey Starostin, Ali Salgiriev, Olga Vlasova, Anna Grinek, Zhanna Nikonova, and Irina Savchenko. "Migration Potential of Students and Development of Human Capital." Education Sciences 12, no. 5 (May 5, 2022): 324. http://dx.doi.org/10.3390/educsci12050324.

Full text
Abstract:
Studying student migration trends is a significant task in studying human capital development as one of the leading factors in sustainable socio-economic development. The migration potential of students impacts the opportunities and prospects for sustainable development. The study of factors influencing the migration behavior of students acquires special significance in this article. The interpersonal competencies of the population impact its migration potential. Migration processes impact the differentiation of regions in terms of human capital. This article is based on theoretical and practical research on human capital, its formation, development, and migration as a factor in human capital development. The practical part of the study presents an analysis of data obtained from a sociological study of the factors that determine internal and international migration. An anonymous sociological survey of students in Ekaterinburg, Kursk, and Tomsk (Russia) was conducted in several stages. The first stage was implemented in October and December 2020 (N = 958). The second stage was implemented in October and November 2021 (N = 960). This study allows for tracing how the COVID-19 pandemic affects the migration potential of students and their desire for a satisfactory career path.
APA, Harvard, Vancouver, ISO, and other styles
36

Dinan, Michaela A., Lesley H. Curtis, William R. Carpenter, Andrea K. Biddle, Amy P. Abernethy, Edward F. Patz, Kevin A. Schulman, and Morris Weinberger. "Stage Migration, Selection Bias, and Survival Associated With the Adoption of Positron Emission Tomography Among Medicare Beneficiaries With Non–Small-Cell Lung Cancer, 1998-2003." Journal of Clinical Oncology 30, no. 22 (August 1, 2012): 2725–30. http://dx.doi.org/10.1200/jco.2011.40.4392.

Full text
Abstract:
Purpose Previous studies have linked the use of positron emission tomography (PET) with improved outcomes among patients with non–small-cell lung cancer (NSCLC). However, this association may be confounded by PET-induced stage migration and selection bias. We examined the association between PET use and overall survival among Medicare beneficiaries with NSCLC. Patients and Methods Retrospective analysis of Surveillance, Epidemiology, and End Results (SEER) –Medicare data was used to characterize changes in overall survival, stage-specific survival, and stage distribution among Medicare beneficiaries with NSCLC between 1998 and 2003. Results A total of 97,007 patients with NSCLC diagnosed between 1998 and 2003 met the study criteria. Two-year and 4-year survival remained unchanged, despite widespread adoption of PET. The proportion of patients staged with advanced disease increased from 44% to 50%. Upstaging of disease was accompanied by stage-specific improved survival, with 2-year survival of stage IV disease increasing from 8% to 11% between 1998 and 2003. PET was more likely to be administered to patients with less advanced disease (stages I through IIIA) and greater overall survival. Conclusion Overall survival among Medicare beneficiaries with NSCLC was unchanged between 1998 and 2003, despite widespread adoption of PET. The association between PET use and increased survival likely reflects an artifact of selection bias and consequent stage migration.
APA, Harvard, Vancouver, ISO, and other styles
37

Su, M., D. C. Merz, M. T. Killeen, Y. Zhou, H. Zheng, J. M. Kramer, E. M. Hedgecock, and J. G. Culotti. "Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans." Development 127, no. 3 (February 1, 2000): 585–94. http://dx.doi.org/10.1242/dev.127.3.585.

Full text
Abstract:
Cell migrations play a critical role in animal development and organogenesis. Here, we describe a mechanism by which the migration behaviour of a particular cell type is regulated temporally and coordinated with over-all development of the organism. The hermaphrodite distal tip cells (DTCs) of Caenorhabditis elegans migrate along the body wall in three sequential phases distinguished by the orientation of their movements, which alternate between the anteroposterior and dorsoventral axes. The ventral-to-dorsal second migration phase requires the UNC-6 netrin guidance cue and its receptors UNC-5 and UNC-40, as well as additional, UNC-6-independent guidance systems. We provide evidence that the transcriptional upregulation of unc-5 in the DTCs is coincident with the initiation of the second migration phase, and that premature UNC-5 expression in these cells induces precocious turning in an UNC-6-dependent manner. The DAF-12 steroid hormone receptor, which regulates developmental stage transitions in C. elegans, is required for initiating the first DTC turn and for coincident unc-5 upregulation. We also present evidence for the existence of a mechanism that opposes or inhibits UNC-5 function during the longitudinal first migration phase and for a mechanism that facilitates UNC-5 function during turning. The facilitating mechanism presumably does not involve transcriptional regulation of unc-5 but may represent an inhibition of the phase 1 mechanism that opposes or inhibits UNC-5. These results, therefore, reveal the existence of two mechanisms that regulate the UNC-5 receptor that are critical for responsiveness to the UNC-6 netrin guidance cue and for linking the directional guidance of migrating distal tip cells to developmental stage advancements.
APA, Harvard, Vancouver, ISO, and other styles
38

Saniga, M., and M. Saniga. "Influence of forest stand structure on the occurrence of bird community in Skalná Alpa National Nature Reserve in the Veľká Fatra Mts. (West Carpathians)." Journal of Forest Science 50, No. 5 (January 11, 2012): 219–34. http://dx.doi.org/10.17221/4618-jfs.

Full text
Abstract:
The study deals with the influence of the structure, texture and dynamics of a spruce-beech primeval forest on the bird community in Skalná Alpa National Nature Reserve in the Veľká Fatra Mts. (West Carpathians, Slovakia) in the years 1982–2002. The abundance of Norway spruce (Picea excelsa Lam.) was highest both in the optimum and decomposition stage. In the growth stage the number of Norway spruce (Picea excelsa Lam.) trees was quite low. The texture of spruce-beech virgin forest was very variable. Percentage ratios of individual stages on the area of 42.16 ha were as follows: growth stage 38.3%, optimum stage 20.1% and decomposition stage 41.6%. Altogether 46 bird species were represented in the bird community during the spring season. Mean total density was 85.8 ind/10 ha. The bird community consisted of 52 species in the summer season, 45 in the autumn migration season, 34 in the winter season, and of 47 in the spring migration season. The highest density was found in the bird community during the autumn migration season (109.8 ind/10 ha), the lowest in the winter season (24.6 ind/10 ha). During the spring migration season, both the spectrum of bird species and total density of bird community increased by the number of migratory species that came back from winter habitats.
APA, Harvard, Vancouver, ISO, and other styles
39

Shi, D. L., T. Darribere, K. E. Johnson, and J. C. Boucaut. "Initiation of mesodermal cell migration and spreading relative to gastrulation in the urodele amphibian Pleurodeles waltl." Development 105, no. 2 (February 1, 1989): 351–63. http://dx.doi.org/10.1242/dev.105.2.351.

Full text
Abstract:
We have investigated the autonomous migration of marginal cells and their interactions with extracellular matrix (ECM) located on the inner surface of the blastocoel roof in the urodele amphibian, Pleurodeles waltl, using a novel in vitro migration assay. Animal hemispheres containing equatorial cells removed at different cleavage stages and dorsal marginal zone (DMZ) explants of early gastrula stage were cultured either on fibronectin (FN)-coated or ECM-conditioned substrata. In explanted animal hemispheres, dorsal marginal cells showed autonomous migration on FN-coated substratum at the same time as the onset of gastrulation in control embryos. They acquired this capacity at least at the 32-cell stage, whereas lateral and ventral marginal cells acquired it after the 64-cell stage. DMZ outgrowths of early gastrula stage exhibited autonomous spreading on both substrata. In addition, we showed that they spread preferentially toward the animal pole when deposited on substratum conditioned by the dorsal roof of the blastocoel. By culturing dissociated marginal cells on ECM- conditioned substratum, we also found that increased spreading capacity of marginal cells was related to the initiation of their migration. A comparative study of the migration of marginal cells in ultraviolet (u.v.)-irradiated and normal embryos was also made. The results indicate that dorsal marginal cell migration was absent or dramatically reduced by u.v.-irradiation. These results suggest that the differential acquisition in the spreading capacity both in timing and in intensity around the marginal zone was correlated with the sequential involution of mesodermal cells in the course of gastrulation.
APA, Harvard, Vancouver, ISO, and other styles
40

Guo, Yuanzhi, and Weifeng Qiao. "Rural Migration and Urbanization in China: Historical Evolution and Coupling Pattern." Sustainability 12, no. 18 (September 6, 2020): 7307. http://dx.doi.org/10.3390/su12187307.

Full text
Abstract:
Using a population dataset of China, this study analyzes the spatial pattern of rural migration and urbanization and their coupling coordination relationship and investigates the causes of their spatial heterogeneity. Results show that rural migration and urbanization from 1978 to 2017 can be divided into three stages, i.e., the recovery and development stage, the stable and rapid development stage, and the stage of promoting the citizenization of the rural migrant population. From 2000 to 2010, counties with average annual growth rates of the ratio of rural migration (GRM) ranging from 0 to 5.00% showed a spatial pattern of ubiquitous distribution, while there were significant spatial inequalities in the average annual growth rates of the urbanization rate of the residential population (GUR) and hukou-registered population (GUH). Since urbanization and rural migration are two synergistic processes, coupling coordination degrees (CCDs) between GRM and GRU as well as GRM and GUH were generally between 0.60 and 0.80. Due to the gaps in socioeconomic development, spatial distance, and the policy system, they also showed regional heterogeneity, and there were notable differences in CCD between rural migration and urbanization of residential and hukou-registered populations. Finally, we propose that China should implement targeted and people-oriented measures to guide rural migration, promote new-type urbanization, and achieve integrated urban–rural development.
APA, Harvard, Vancouver, ISO, and other styles
41

Miller, Jessica L., Anke Harupa, Stefan H. I. Kappe, and Sebastian A. Mikolajczak. "Plasmodium yoelii Macrophage Migration Inhibitory Factor Is Necessary for Efficient Liver-Stage Development." Infection and Immunity 80, no. 4 (January 17, 2012): 1399–407. http://dx.doi.org/10.1128/iai.05861-11.

Full text
Abstract:
ABSTRACTMammalian macrophage migration inhibitory factor (MIF) is a multifaceted cytokine involved in both extracellular and intracellular functions. Malaria parasites express a MIF homologue that might modulate host immune responses against blood-stage parasites, but the potential importance of MIF against other life cycle stages remains unstudied. In this study, we characterized the MIF homologue ofPlasmodium yoeliithroughout the life cycle, with emphasis on preerythrocytic stages.P. yoeliiMIF (Py-MIF) was expressed in blood-stage parasites and detected at low levels in mosquito salivary gland sporozoites. MIF expression was strong throughout liver-stage development and localized to the cytoplasm of the parasite, with no evidence of release into the host hepatocyte. To examine the importance of Py-MIF for liver-stage development, we generated a Py-mifknockout parasite (P. yoeliiΔmif).P. yoeliiΔmifparasites grew normally as asexual erythrocytic-stage parasites and showed normal infection of mosquitoes. In contrast, theP. yoeliiΔmifstrain was attenuated during the liver stage. Mice infected withP. yoeliiΔmifsporozoites either did not develop blood-stage parasitemia or exhibited a delay in the onset of blood-stage patency. Furthermore,P. yoeliiΔmifparasites exhibited growth retardationin vivo. Combined, the data indicate thatPlasmodiumMIF is important for liver-stage development ofP. yoelii, during which it is likely to play an intrinsic role in parasite development rather than modulating host immune responses to infection.
APA, Harvard, Vancouver, ISO, and other styles
42

Pityulych, Mykhaylo, and Volodymyr Hoblyk. "SYSTEM APPROACH TO ANALYSIS OF THE ESSENCE OF MIGRATION PROCESSES." Scientific Bulletin of Mukachevo State University. Series “Economics” 1(13) (2020): 45–50. http://dx.doi.org/10.31339/2313-8114-2020-1(13)-45-50.

Full text
Abstract:
Ukraine's integration into the European Economic Area is accompanied by large-scale labor migration of economically active population. Under the current conditions, it takes on new forms of quality, the motivational component of labor displacements is changing, the structure of the population included in the sphere of migration processes has undergone significant changes, the share of persons with high professional qualification and educational level and considerable work experience has increased. All this requires deep reflection and investigation of the cause and effect relationships of labor migration, a thorough scientific analysis of current trends, identification of benefits and potential threats to the country, the formation of a well-considered state labor migration policy. Paying attention to existing scientific developments, it should be noted that studies of labor migration processes, with a small exception, are at an early stage: many methodological and organizational aspects of their regulation are not properly disclosed, they lack a deep scientific understanding of the essence of migration processes as a complex social and economic phenomenon. The article attempts to reveal the epistemological nature and essence of the migration process as a complex system of social order. Particular attention is paid to the analysis of its system-forming components, which are in causal relationships and ensure its integrity, which is important for the formation of organizational and economic mechanism of regulation of labor migration processes. In the course of the research it was found out that the migration process as a complex system involves a number of interrelated stages - migration environment, migration situation, migration behavior, migration movement, i.e. mobility and adaptation of labor migrants. The article focuses on the analysis of the initial, basic stage of the migration process - the migration environment, which determines the migration situation, under the influence of which migration behavior is formed, and therefore migration mobility and the intensity of labor movements. This understanding of the nature of migration processes is essential for the practice of regulating migration processes and for the formation of an organizational and economic mechanism for regulating labor movements. The analysis of each of the isolated stages makes it possible to ensure the systematic and comprehensive management of labor migration processes, to increase the efficiency of the state migration policy. Keywords: migration process, stages of migration process, mechanism, regulation.
APA, Harvard, Vancouver, ISO, and other styles
43

Gao, Yanan, Peng Guo, Zetian Zhang, Minghui Li, and Feng Gao. "Migration of the Industrial Wastewater in Fractured Rock Masses Based on the Thermal-Hydraulic-Mechanical Coupled Model." Geofluids 2021 (October 16, 2021): 1–13. http://dx.doi.org/10.1155/2021/5473719.

Full text
Abstract:
Industrial wastewater may have a long-time effect on the environment and human life as it goes underground and causes serious pollution continuously. To have a well understanding of the migration of such wastewater is a basic task for industrial wastewater treatment as well as industrial design. To study the migration mechanism of industrial wastewater in rock formations, the governing equations such as mechanics, seepage, heat, and mass transfer are reviewed, referenced, and proposed. The thermal (T)-hydraulic (H)-mechanical (M) coupled model of the multimedia of matrix-fault and matrix-fracture-fault is established. The influence of the fault and the fractures on the pressure distribution and contaminant migration is analyzed. The influence of fault length, width, dip angle, permeability, and temperature of wastewater on contaminant migration is parametrically studied. The following results can be obtained. (1) The fracture quantitively affects the concentration distribution, while the fault dominates the concentration distribution and contaminant migration. (2) The migration of the contaminants can be geometrically divided into 3 zones along the direction of the fault: the saturation zone, the rapid diffusion zone, and the concentration decrease zone. (3) There is a peak of the concentration along the bottom of the model. The position of the peak is the projection of the endpoint of the fault. (4) The fault length has the most significant effect on contaminant accumulation. The temperature of the wastewater has the minimum effect on the contaminant accumulation. (5) The accumulation of concentrations can be divided into 2 stages, the slow growth stage (before 20 years) and the rapid growth stage (after 20 years). The main channel of contaminant migration in the slow growth stage is a fault. During the rapid growth stage, the contaminants penetrate through the rock matrix as well as the fault.
APA, Harvard, Vancouver, ISO, and other styles
44

Kapoor, Prashant, Shaji Kumar, Morie A. Gertz, Martha Lacy, David Dingli, Stephen J. Russell, Francis Buadi, et al. "Does stage migration exist in active multiple myeloma (MM)?" Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 8105. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.8105.

Full text
Abstract:
8105 Background: Tumor stage migration can artifactually inflate cancer survival rates and overestimate benefits of newer therapies. We have previously shown a favorable impact of widely used novel agents in MM patients. However, it is not known whether use of well tolerated and easily administrable novel agents results in their introduction at lower levels of MM burden (and therefore add to improved outcome). Our goal was to assess for stage migration in newly diagnosed active MM patients. Methods: We reviewed records of 1,467 patients with active MM at Mayo Clinic, at initiation of therapy from 3 consecutive 5-year intervals: 01/1996-12/2000 (Group 1), 01/2001-12/2005 (Group 2), 01/2006- 12/2010 (Group 3). These intervals reflect the practice changing approaches at our center transitioning from the use of alkylator-based to novel agent-based initial therapy. Traditional parameters and staging systems were used to estimate tumor burden. We performed one way analysis of variance (ANOVA) to assess for differences in these parameters among the groups. A p-value of <0.05 was considered significant. Results: Group 3 shows an upward trend for hemoglobin (Hgb), and lower creatinine and bone marrow plasma cell (BMPC) percent. Compared to other groups, a greater proportion of Group 3 patients are assigned to lower Durie Salmon (DS) stages (Table) suggesting reduced tumor burden at therapy initiation. In contrast, the International Staging System (ISS) which is not used for decisions regarding therapy initiation divides cohorts in similar proportions. Conclusions: Stage migration is evident in our cohort of active MM patients presenting in the time periods of evolving initial therapeutic strategies. Future studies should take into account the bias introduced by this phenomenon in interpreting survival analysis of MM patients. [Table: see text]
APA, Harvard, Vancouver, ISO, and other styles
45

Hogan, Michelle. "PSA-Induced Stage Migration Appears to Have Reached Plateau." Oncology Times 29, no. 8 (April 2007): 31. http://dx.doi.org/10.1097/01.cot.0000269631.96533.ff.

Full text
APA, Harvard, Vancouver, ISO, and other styles
46

Bonner, J. T. "The migration stage ofDictyostelium: Behavior without muscles or nerves." FEMS Microbiology Letters 120, no. 1-2 (July 1994): 1–7. http://dx.doi.org/10.1111/j.1574-6968.1994.tb06997.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
47

Horninger, W., A. Pelzer, A. Berger, and G. Bartsch. "396 Stage migration in prostate cancer — a changing landscape." European Urology Supplements 3, no. 2 (February 2004): 101. http://dx.doi.org/10.1016/s1569-9056(04)90394-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
48

Padaki, Pavan, Emma Critchley, Reju Joy, Ajay Wilson, and Shakeel Akhtar. "Stage migration in patients with head and neck cancer." British Journal of Oral and Maxillofacial Surgery 54, no. 10 (December 2016): e84. http://dx.doi.org/10.1016/j.bjoms.2016.11.057.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

Volpe, Alessandro. "mRCC stage migration: implications for trial design and analysis." Nature Reviews Urology 7, no. 5 (May 2010): 242–44. http://dx.doi.org/10.1038/nrurol.2010.60.

Full text
APA, Harvard, Vancouver, ISO, and other styles
50

Layeequr Rahman, Rakhshanda, Eric Siegel, Cristiano Boneti, Malene Ingram, Julie Kepple, Ronda S. Henry-Tillman, and V. Suzanne Klimberg. "Stage migration with sentinel node biopsy in breast cancer." American Journal of Surgery 197, no. 4 (April 2009): 491–96. http://dx.doi.org/10.1016/j.amjsurg.2008.07.052.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Stage migration' for other source types:
Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography