Relevant bibliographies by topics / ST14

Academic literature on the topic 'ST14'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "ST14"

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Giske, Christian G., Inga Fröding, Chowdhury Mehedi Hasan, Agata Turlej-Rogacka, Mark Toleman, David Livermore, Neil Woodford, and Timothy R. Walsh. "Diverse Sequence Types of Klebsiella pneumoniae Contribute to the Dissemination ofblaNDM-1in India, Sweden, and the United Kingdom." Antimicrobial Agents and Chemotherapy 56, no. 5 (February 21, 2012): 2735–38. http://dx.doi.org/10.1128/aac.06142-11.

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ABSTRACTClinical isolates ofKlebsiella pneumoniaeproducing NDM-1 carbapenemase from India (n= 22), the United Kingdom (n= 13), and Sweden (n= 4) were subjected to multilocus sequence typing (MLST), automated repetitive sequence-based PCR (rep-PCR), serotyping, virulence gene screening, and plasmid replicon typing. The most frequently detected MLST sequence types (STs) were ST14 (n= 13; all serotype K2), ST11, ST149, ST231, and ST147. The correlation between MLST and automated rep-PCR was excellent. IncA/C was the most frequently detected plasmid replicon type (n= 14). ST14, ST11, and other successful clones may be important for the dissemination ofblaNDM-1.
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Rudzińska, Monika, Beata Kowalewska, Małgorzata Waleron, Mirosław Kalicki, Katarzyna Sikorska, and Beata Szostakowska. "Molecular Characterization of Blastocystis from Animals and Their Caregivers at the Gdańsk Zoo (Poland) and the Assessment of Zoonotic Transmission." Biology 10, no. 10 (September 30, 2021): 984. http://dx.doi.org/10.3390/biology10100984.

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Blastocystis is a highly genetically diverse gut protist commonly found in humans and various animals. The role of animals in human infection is only partly understood. The aim of this study was to determine the host specificity and possibility of zoonotic transmission of this microorganism. Subtypes of Blastocystis isolated from 201 zoo animals and their 35 caregivers were identified by sequencing of the SSU rRNA gene. Blastocystis was found in 26.86% of animal and 17.14% of human samples. Both mammalian (ST1–ST3, ST5, ST8, ST10, ST13, ST14) and non-mammalian subtypes were detected. Of the subtypes found in non-human primates (ST1, ST2, ST3, and ST13), two subtypes (ST1 and ST3) were also detected in humans. The presence of identical ST1 sequences in three monkeys and their caregiver indicates the possibility of direct transmission of Blastocystis between these animals and humans. Detection of ST5 only in wild boars and peccaries, ST8 only in Marsupial, ST10 and ST14 only in Bovidae, and non-mammalian subtypes in reptiles suggests higher host specificity for these subtypes, and indicates that their transmission between animals and humans is unlikely. Additionally, this was probably the first time that ST5 was found in peccaries, ST2 in patas monkeys, and ST8 in red kangaroos.
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Maloney, Jenny G., Yunah Jang, Aleksey Molokin, Nadja S. George, and Monica Santin. "Wide Genetic Diversity of Blastocystis in White-Tailed Deer (Odocoileus virginianus) from Maryland, USA." Microorganisms 9, no. 6 (June 21, 2021): 1343. http://dx.doi.org/10.3390/microorganisms9061343.

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Blastocystis is a gastrointestinal protist frequently reported in humans and animals worldwide. Wildlife populations, including deer, may serve as reservoirs of parasitic diseases for both humans and domestic animals, either through direct contact or through contamination of food or water resources. However, no studies of the occurrence and subtype distribution of Blastocystis in wildlife populations have been conducted in the United States. PCR and next generation amplicon sequencing were used to determine the occurrence and subtypes of Blastocystis in white-tailed deer (Odocoileus virginianus). Blastocystis was common, with 88.8% (71/80) of samples found to be positive. Twelve subtypes were identified, ten previously reported (ST1, ST3, ST4, ST10, ST14, ST21, and ST23–ST26) and two novel subtypes (ST30 and ST31). To confirm the validity of ST30 and ST31, MinION sequencing was used to obtain full-length SSU rRNA gene sequences, and phylogenetic and pairwise distance analyses were performed. ST10, ST14, and ST24 were the most commonly observed subtypes. Potentially zoonotic subtypes ST1, ST3, or ST4 were present in 8.5% of Blastocystis-positives. Mixed subtype infections were common (90.1% of Blastocystis-positives). This study is the first to subtype Blastocystis in white-tailed deer. White-tailed deer were found to be commonly infected/colonized with a wide diversity of subtypes, including two novel subtypes, zoonotic subtypes, and subtypes frequently reported in domestic animals. More studies in wildlife are needed to better understand their role in the transmission of Blastocystis.
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Chen, Shanyu, Wanyu Meng, Ziyao Zhou, Lei Deng, Xiaogang Shi, Yijun Chai, Haifeng Liu, et al. "Genetic characterization and zoonotic potential of Blastocystis from wild animals in Sichuan Wolong National Natural Reserve, Southwest China." Parasite 28 (2021): 73. http://dx.doi.org/10.1051/parasite/2021071.

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Blastocystis is a prevalent eukaryotic parasite that has been identified in a wide range of hosts. Several species are considered potential sources of Blastocystis infection in humans, but little is known about the prevalence of Blastocystis in wild animals. In this study, the prevalence and subtypes of Blastocystis were investigated to assess the zoonotic potential of wild animals in Sichuan Wolong National Natural Reserve. A total of 300 fecal samples were collected from 27 wildlife species in three areas of the Reserve. The subtype (ST), genetic characteristics, and prevalence of Blastocystis were determined by PCR amplification of part (~600 bp) of the SSU rRNA gene. Thirty fecal samples (10.0%) were Blastocystis-positive. The highest prevalence of Blastocystis was found in Yinchanggou (18.3%), with significantly less found in Niutoushan (7.5%) and Genda (5.5%) (p < 0.05). No significant differences were associated with different orders of animals in prevalence, which may be because of the small number of positive samples obtained. Sequence analysis showed five subtypes (ST1, ST3, ST5, ST13, and ST14), with ST13 and ST14 being predominant (33% each), followed by ST1 (20%). This is the first molecular investigation of Blastocystis infection in the wild animals of southwestern China. Subtypes ST1, ST3, ST5, and ST14 have previously been identified in humans, suggesting that wild animals may be potential reservoirs of Blastocystis for humans.
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Muraya, Angela, Cecilia Kyany’a, Shahiid Kiyaga, Hunter J. Smith, Caleb Kibet, Melissa J. Martin, Josephine Kimani, and Lillian Musila. "Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing." Pathogens 11, no. 5 (May 5, 2022): 545. http://dx.doi.org/10.3390/pathogens11050545.

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Klebsiella pneumoniae is a globally significant opportunistic pathogen causing healthcare-associated and community-acquired infections. This study examined the epidemiology and the distribution of resistance and virulence genes in clinical K. pneumoniae strains in Kenya. A total of 89 K. pneumoniae isolates were collected over six years from five counties in Kenya and were analyzed using whole-genome sequencing and bioinformatics. These isolates were obtained from community-acquired (62/89) and healthcare-associated infections (21/89), and from the hospital environment (6/89). Genetic analysis revealed the presence of blaNDM-1 and blaOXA-181 carbapenemase genes and the armA and rmtF genes known to confer pan-aminoglycoside resistance. The most abundant extended-spectrum beta-lactamase genes identified were blaCTX-M-15 (36/89), blaTEM (35/89), and blaOXA (18/89). In addition, one isolate had a mobile colistin resistance gene (mcr-8). Fluoroquinolone resistance-conferring mutations in gyrA and parC genes were also observed. The most notable virulence factors were those associated with hyper-virulence (rmpA/A2 and magA), yersiniabactin (ybt), salmochelin (iro), and aerobactin (iuc and iutA). A total of 38 distinct sequence types were identified, including known global lineages ST14, ST15, ST147, and ST307, and a regional clone ST17 implicated in regional outbreaks. In addition, this study genetically characterized two potential hypervirulent isolates and two community-acquired ST147 high-risk clones that contained carbapenemase genes, yersiniabactin, and other multidrug resistance genes. These results demonstrate that the resistome and virulome of Kenyan clinical and hospital environmental K. pneumoniae isolates are diverse. The reservoir of high-risk clones capable of spreading resistance, and virulence factors have the potential to cause unmanageable infection outbreaks with high morbidity and mortality.
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Khaled, Salma, Nausicaa Gantois, Amadou Tidjani Ly, Simon Senghor, Gaël Even, Ellena Dautel, Romane Dejager, et al. "Prevalence and Subtype Distribution of Blastocystis sp. in Senegalese School Children." Microorganisms 8, no. 9 (September 12, 2020): 1408. http://dx.doi.org/10.3390/microorganisms8091408.

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Blastocystis sp. is an enteric protozoan that frequently colonizes humans and many animals. Despite impacting on human health, data on the prevalence and subtype (ST) distribution of Blastocystis sp. remain sparse in Africa. Accordingly, we performed the first multicenter and largest epidemiological survey ever conducted on Blastocystis sp. for this continent. A total of 731 stool samples collected from healthy school children living in 10 villages of the northwestern region of Senegal were tested for the presence of Blastocystis sp. by real-time polymerase chain reaction followed by subtyping of positive samples. Considerable variation in prevalence between villages (51.7 to 100%) was evident with the overall prevalence being 80.4%. Mixed infections were identified in 23% of positive individuals. Among 453 school children with a single infection, ST2 was predominant, followed by ST1, ST3, ST7, ST10, and ST14; this is the first report of ST10 and ST14 in humans. Genetic polymorphisms were evident at the intra-ST level with the identification of numerous ST1 to ST3 genotypes. ST1 showed the greatest intra-ST diversity followed by ST2 and ST3. The prevalence and distribution of STs and genotypes varied among target villages, pointing to several potential infection sources, including human-to-human, zoonotic, and waterborne transmission.
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Chen, Shanyu, Wanyu Meng, Xianpeng Shi, Yijun Chai, Ziyao Zhou, Haifeng Liu, Zhijun Zhong, et al. "Occurrence, genetic diversity and zoonotic potential of Blastocystis sp. in forest musk deer (Moschus berezovskii) in Southwest China." Parasite 29 (2022): 34. http://dx.doi.org/10.1051/parasite/2022037.

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Blastocystis sp. is a common anaerobic protist with controversial pathogenicity that can infect various animals and humans. However, there are no reports of Blastocystis sp. infections in forest musk deer (Moschus berezovskii). The present study was designed to examine the occurrence, subtype distribution and genetic characterization of Blastocystis sp. in forest musk deer in southwestern China, and to assess the potential for zoonotic transmission. A total of 504 fresh stool samples were collected from captive forest musk deer in four distinct areas of southwestern China. Overall, 14.7% of the forest musk deer (74/504) were found to be infected with Blastocystis sp. The highest occurrence of Blastocystis sp. was observed in Dujiangyan (27.5%), followed by Maerkang (23.3%). The occurrence of Blastocystis sp. was 7.9% and 4.1% in Shimian and Hanyuan, respectively. Significant differences in the occurrence of Blastocystis sp. among different areas were observed (p < 0.05), while we did not observe significant differences among animals of different age and sex (p > 0.05). Two known zoonotic subtypes (ST1 and ST5) and three animal-predominant subtypes (ST10, ST13, and ST14) were identified, of which ST10 was the most common (36/74, 48.6%). Our findings highlight that forest musk deer may be potential reservoirs of zoonotic human Blastocystis sp. infections.
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Baek, Sohyeong, Jenny G. Maloney, Aleksey Molokin, Nadja S. George, Jesús A. Cortés Vecino, and Monica Santin. "Diversity of Blastocystis Subtypes in Horses in Colombia and Identification of Two New Subtypes." Microorganisms 10, no. 9 (August 24, 2022): 1693. http://dx.doi.org/10.3390/microorganisms10091693.

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Blastocystis is a common intestinal protist in humans and animals worldwide. Wild and domestic animals are thought to be reservoirs of Blastocystis subtypes that also infect humans. There are limited studies on the prevalence and subtype distribution of Blastocystis in horses. In this study, 185 fecal samples were collected from horses (1 month to 17 years of age) in four regions of Colombia (Sabana de Bogotá, Costa Atlántica, Llanos Orientales, and Bogotá D.C.). Blastocystis presence and subtypes were determined by PCR and next generation amplicon sequencing. Eighty-one (43.8%) horses were positive for Blastocystis, with positive horses in all four regions. Molecular characterization identified 12 Blastocystis subtypes, 10 known subtypes (ST1, ST3–ST6, ST10, ST14, ST25, ST26), and 2 novel subtypes (ST33 and ST34). The validity of the novel subtypes was confirmed via phylogenetic and pairwise distance analyses of the full-length SSU rRNA gene sequences. Mixed subtype infections were common (55.6% of Blastocystis-positive horses). ST10 was the most prevalent subtype, present in 82.8% of Blastocystis-positive horses. Potentially zoonotic subtypes were identified in 88.9% of the Blastocystis-positive horses. This constitutes the most comprehensive study of Blastocystis in horses. Our findings indicate that horses harbor potentially zoonotic subtypes and could contribute to the transmission of Blastocystis to humans.
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Liu, Hui, Yan Yu, and Jun Jing He. "Spot Weldability Comparison of High Strength Steel BIF340 and Normal Cold-Rolled Steel St14." Advanced Materials Research 154-155 (October 2010): 846–51. http://dx.doi.org/10.4028/www.scientific.net/amr.154-155.846.

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The experimental investigation was carried out to compare resistance spot weldability of BIF340 and St14 steel in different weld processes.The spot weld microstructure and properties of two steels were analyzed.The results shown that : resistance spot weldability of BIF340 is better than St14.The optimum parameters of BIF340 were as follows: welding current was 6KA,welding time was 7 cycles, electrode force was 2800N. With the same welding process parameters, the microstructure of BIF340 spot weld was homogeneous and fine-grained, and the tensile shear strength was higher than St14.
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Zhang, Peiyang, Qingxun Zhang, Shuyi Han, Guohui Yuan, Jiade Bai, and Hongxuan He. "Occurrence and Genetic Diversity of the Zoonotic Enteric Protozoans and Enterocytozoon bieneusi in Père David’s Deer (Elaphurus davidianus) from Beijing, China." Pathogens 11, no. 11 (October 23, 2022): 1223. http://dx.doi.org/10.3390/pathogens11111223.

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Cryptosporidium spp., Blastocystis, Giardia duodenalis, Balantioides coli, Pentatrichomonas hominis, and Enterocytozoon bieneusi are enteric protozoan parasites and fungal species in humans and animals. Père David’s deer is an endangered species in China, but the prevalence of enteric protozoans in this species still needs to be further studied. Thus, we investigated the prevalence and genetic diversity of zoonotic parasites in Père David’s deer during the period of 2018–2021. Among the 286 fecal samples collected from Père David’s deer in the Nanhaizi Nature Reserve, 83 (29.0%) were positive for Blastocystis, 70 (24.5%) were positive for E. bieneusi, while other protozoan parasites were negative. Based on a phylogenetic analysis, three Blastocystis subtypes (ST10, ST14, and ST21) and ten E. bieneusi genotypes (Genotype D, MWC_d1, HLJD-V, Peru6, BEB6, BJED-I to BJED-I V) were identified. In addition, the Blastocystis subtype ST14 and the E. bieneusi genotype D and Peru6 were first detected in Père David’s deer. Our study first reports the presence of two enteric protozoans in Père David’s deer during a 4-year active surveillance and provides more information about zoonotic subtypes/genotypes of Blastocystis and E. bieneusi in deer.
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Dissertations / Theses on the topic "ST14"

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Henry, Cindy. "Le rôle de ST18 dans la cellule pancréatique bêta." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28661/28661.pdf.

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Zaya, Johan, and Amanda Strömberg. "Optimering av St1s anläggning med integrering : Vägen till en hållbar utveckling." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-10278.

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Många företag och industrier arbetar idag ständigt med att utveckla mindre miljöbelastande sätt att arbeta på, det beror på hårdare lagar och regler än tidigare angående utsläpp till miljön. Företag inventerar mycket resurser på ny forskning och ta fram nya metoder, allt för att bidra till en hållbar utveckling. St1 är ett av de företagen som vill vara med i arbetet för en hållbar utveckling och främst av förnybara bränslen. St1 har utvecklat en ny metod för framställning av etanol utav restråvaror från livsmedelsindustrin. Det bildas även drank som är en biprodukt som man kör ut till lantbruk för att använda som djurfoder eller vid produktion av biogas. Metoden benämns som Etanolix och den nya anläggningen på St1 Refinery AB är den senaste som fått namnet Etanolix 2.0. Syftet med rapporten är att visa hur integrering kan göras med en ny anläggning tillsammas med en redan befintlig och hur man kan ta till vara på outnyttjade resurser. I rapporten beskrivs de olika hjälpsystem som är integrerade med Etanolix 2.0 som processvatten, kvävgas samt ånga och kondensat. Det beskrivs också hur första året med Etanolix 2.0 i drift har gått och vad som varit utmaningarna vid uppstarten. Slutsatsen vi kom fram till är att Etanolix metoden bidrar till en hållbar utveckling och steget närmare att skapa framtida förnybara bränslen. Projekt Etanolix 2.0 är fortfarande i uppstartningsfasen och behöver ytterligare utveckling innan optimal produktion av etanol kan ske.
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McElroy, Cameron Shea. "The Role of SULT2 ST1 in Zebrafish Development." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1273786802.

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Larsson, Kim, and Emil Karlsson. "St1 Refinery - Biotreater : Optimering och utvecklingsmöjligheter med hänseende till miljön." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-14976.

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Vatten är en viktig komponent för alla oljeraffinaderier, både för kylning och för själva destillationsprocessen. Vatten som har kommit i kontakt med olja, sulfider, kväveföreningar samt andra miljöfarliga ämnen, kallas processvatten och måste renas innan det släpps ut i recipient. Processvattnet renas i vattenreningsverk som kan se olika ut och ha olika uppbyggnad.St1 Refinery AB ligger på Hisingen i Göteborg vid Göta älv och har ett biologiskt vattenreningsverk som kallas Biotreatern. Biotreatern har i uppgift att rena processvattnet främst ifrån kväveföreningar, men även olja och andra miljöfarliga ämnen med hjälp av bakterier. Biotreatern har problem med så kallat slamflykt, detta kan påverka att utsläppskrav för bl.a. mängden olja och kväveföreningar i renat vatten överskrids. Om utsläppskraven överskrids kan detta leda till höga bötersbelopp för företaget och en ökad negativ påverkan på miljön. Syftet med rapporten är att ta fram förslag på förbättringar och nya tekniska lösningar till Biotreatern för att minska slamflykten. I rapporten redovisas resultat som främst handlar om nya filtreringstekniker, hur dessa fungerar och var i anläggningen de kan appliceras för att undvika slamflykt. Vilka huvudsakliga faktorer som styr reningsprocessen och vad begreppet slamflykt innebär, beskrivs i rapporten. Det beskrivs också hur reningsprocessen fungerar, tillsammans med uppritat flödesschema över anläggningen. De förbättringsförslag som presenteras i rapporten, kan minska och eventuellt eliminera problemet med slamflykt som Biotreatern lider av idag.
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Bengtson, Mário Henrique. "Caracterização celular e molecular dos efeitos do ácido retinóico sobre as células ST1 de glioma de rato." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-05072018-121057/.

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Os gliomas são os tumores mais fatais do sistema nervoso central, para os quais ainda não há tratamento eficaz. Para analisar as bases celulares e moleculares da ação do agente diferenciador e antitumoral ácido retinóico (ATRA) sobre gliomas, foi utilizado, como modelo, a linhagem STl de glioma de rato. Propôs-se: a) analisar os efeitos de ATRA sobre a morfologia, proliferação e morte celular; b) isolar, identificar e caracterizar genes induzidos por ATRA em células STl. Verificou-se que o tratamento com ATRA promove achatamento celular e inibição da síntese de DNA e do crescimento em suspensão de agarose, caracterizando uma completa reversão fenotípica tumoral-normal, a qual não é acompanhada de indução de apoptose. Os genes induzidos por ATRA foram isolados através da construção de bibliotecas subtraídas de cDNA por: RDA (\"Representational Diference Analysis\") e SSH (\"Suppressive Subtractive Hybridization\") acoplados a rastreamento em \"macroarrays\". Foram identificados 10 genes regulados por ATRA durante a reversão fenotípica das células STl: p450rai2, spi3, vegf, cdv-3a, okl38, eya2, gem, retSDR1, aldose redutase-like, e um gene novo, com 61 % de identidade com uma fosfatase de galinha. Este estudo permitiu a caracterização dos efeitos de ATRA sobre STl e identificou novos alvos para futuro desenvolvimento de novas drogas e terapia gênica.
Gliomas are the most fatal central nervous system tumors, for which efficient treatment is still not available. To analyze the cellular and molecular bases for the action of the differentiating and anti-tumor agent retinoic acid (ATRA) in gliomas, the rat glioma STl cell line was used as a model. We proposed: a) to analyze the effects of ATRA in STl cells morphology, growth and apoptosis; b) to isolate, identify and characterize the ATRA-induced genes in STl cells. We demonstrated that ATRA promotes cellular flattening and inhibition of DNA synthesis and growth in agarose suspension, characterizing a complete tumoral to normal phenotypic reversion, which is not accompanied by apoptosis. Subtracted cDNA libraries were generated, using 2 different methodologies: RDA (Representational Difference Analysis) and SSH (Suppressive Subtractive Hybridization) followed by macroarray screening. This allowed identification of 10 ATRA induced genes which are up regulated by ATRA during STl cells phenotypic reversion, namely: p450rai2, spi3, vegf, cdv-3a, okl38, eya2, gem, retSDR1, aldose redutase-like and a new gene with 61 % identity with chicken phosphatase. This study characterized the cellular and molecular effects of ATRA upon STl cells and allowed identification of new targets for future development of new drugs and gene therapy.
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Tajjiou, Morad [Verfasser]. "Design und Entwicklung molekularbiologischer Modelle zur Charakterisierung der Mobilität des Clostridium difficile IStrons Cd/St1 / Morad Tajjiou." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/1238223796/34.

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Vandewalle-Capo, Marine. "Étude de la sensibilité aux antibiotiques et aux peptides antimicrobiens humains de Legionella pneumophila." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1291/document.

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Legionella pneumophila (Lp) est un pathogène accidentel de l'homme capable d'infecter les macrophages alvéolaires et les pneumocytes. Au cours de l'infection, Legionella se confronte à différents types d'agents antibactériens, dont les peptides antimicrobiens (PAMs) produit par l'hôte et les antibiotiques à activité intracellulaire administrés aux patients. Le mécanisme d'action des PAMs humains à l'encontre de Legionella, ainsi que le niveau de résistance aux antibiotiques de la bactérie sont à ce jour encore peu documentés. Mes travaux ont pour but de contribuer à une meilleure connaissance de l'activité anti-Legionella de ces molécules. La première partie de cette étude a consisté à évaluer la sensibilité d'isolats cliniques de Lp sg 1 à 8 antibiotiques, afin de déterminer le seuil épidémiologique de sensibilité de la bactérie à ces différentes molécules. Nous avons démontré que l'ensemble des isolats cliniques sont sensibles aux antibiotiques testés. Les résultats ont révélé l'existence d'une sous-population présentant une sensibilité réduite aux macrolides. L'analyse des génomes a permis de corréler cette sensibilité diminuée à la présence de la pompe à efflux LpeAB spécifique des macrolides. Cette pompe est présente uniquement dans trois complexes clonaux centrés sur le ST1, le ST701 et le ST1335.La seconde partie de cette étude a été consacrée à la caractérisation de l'activité antibactérienne des PAMs humains LL-37 et HBD-3, ainsi qu'à l'identification de leur(s) mécanisme(s) d'action contre Legionella. L'ensemble des tests réalisés montre que LL-37 et HBD-3 induisent une perte de cultivabilité des légionelles par des modes d'action différents. Les résultats suggèrent que LL-37 agit par perméabilisation des membranes de L. pneumophila. Nos résultats ont également montré que les deux peptides exercent une activité inhibitrice sur la réplication intracellulaire des légionelles, au moins en partie grâce à une collaboration avec la cellule hôte
Legionella pneumophila (Lp) is an accidental human pathogen which can infect alveolar macrophages and pneumocytes. During infection, Legionella have to deal with to various types of antibacterial agents, such as antimicrobial peptides (AMPs) produced by the host, and antibiotics with intracellular activity administered to patients. The mechanism of action of human AMPs against Legionella, and the resistance level to antibiotics of the bacterium are still poorly described. Our work aimed to contribute to a better understanding of the anti-Legionella activity of these molecules. The first part of this study consisted in the evaluation of the susceptibility of clinical Lp sg1 isolates to 8 antibiotics, to determine the epidemiological cut-off values of these different molecules. We demonstrated that all clinical isolates are susceptible to the tested antibiotics. The results revealed the presence of a subpopulation displaying a reduced susceptibility to macrolides. The analysis of the genomes allowed us to correlate this reduced susceptibility to le presence of the LpeAB macrolides efflux pump, found specifically in the sequence types ST1, ST701 and ST1335.The second part of this study was dedicated to the characterization of the antibacterial activity of the human AMPs LL-37 and HBD-3, and to the identification of their mechanism(s) of action against Legionella. All of the experiments show that LL-37 and HBD-3 induce a loss of cultivability by different mode of action. The results suggest that LL-37 is able to permeabilize the membrane of the L. pneumophila cells. Our findings also show that both peptides inhibit the intracellular replication of L. pneumophila, in part through collaboration with the host cell
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Ortis, Fernanda. "Papel de BRG1 e Brm, reguladores globais de transcrição, na reversão fenotípica de células ST1 pela ação de glicocorticóides." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-26072007-053713/.

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Os hormônios glicocorticóides (GCs) têm sido amplamente empregados como agentes antiinflamatórios e anti-tumorais. Sua ação ocorre via receptores nucleares (GR) sendo dependente da remodelação da estrutura da cromatina. As proteínas Brm e BRG1, componentes essenciais de um complexo regulador global da transcrição (SWI/SNF), por remodelamento da cromatina, exercem um papel-chave na ação de GR. Para estudar o mecanismo de ação de GCs, foram utilizadas as linhagens celulares ST1 e P7, derivadas da linhagem celular C6, de glioma de rato. P7 é insensível ao tratamento com GC, enquanto ST1 apresenta reversão fenotípica tumoral→normal, gerando um bloqueio específico na fase G1. Um anti-soro policlonal específico para Brm e BRG1, foi gerado através da inoculaçâo de coelha com a proteína hBRG1 recombinante. Este antisoro foi utilizado para análisar os níveis destas proteínas nas duas linhagens celulares, sob ação de GC. Enquanto em ST1, Brm é induzida por GC, em células P7, o nível basal de Brm é relativamente alto, mantendo-se inalterado na presença de GC. A possíbilidade de existirem mutações no gene brm de células P7, foi investigada através de amplificação do DNA, por PCR, e seqüenciamento. A superexpressão de brm e BRG1 em células P7 mostrou que clones isolados apresentavam, de um modo geral, achatamento celular, diminuição da taxa de crescimento e da eficiência de plaqueamento em substrato sólido e semi-sólido. Alguns destes clones passaram a responder ao tratamento com GC, porém não tão drasticamente como as células ST1. Co-imunonoprecipitação mostrou algumas diferenças entre os complexos SWI/SNF de células ST1 e P7.
Glucocorticoid hormones (GCs) have been used as anti-inflammatory and anti-tumor agents, acting via nuclear receptors (GR) and being dependent on remodeling of the chromatin structure. As components of the global chromatin remodeling transcription complex (SWI/SNF), Brm and BRG-1 proteins play a key role in the action of GR. In order to study the mechanisms of action of GCs, we have been using the ST1 and P7 cell lines, derived from the C6, a rat glioma cell line. P7 is insensitive to the GC treatment, while ST1 displays a complete phenotypic reversion from tumoral to normal, including a G1-specific block in the cell cycle. A Brm and BRG1-specific polyclonal antiserum was generated, in rabbit, using recombinant hBRG1 protein as antigen. This antiserum was used to analyze the levels of Brm and BRG1 in these two cell lines, under GC treatment. While Brm is induced by GC, in ST1 cells, the basal level of Brm, in P7 cells, is relatively high, remaining unchanged under GC treatment. The possibility of brm mutations occurring in the P7 cells, was analyzed by DNA sequencing. Overexpression of brm and BRG1 in P7 cells led to morphological alterations (cell flattening) and decreased colony formation in agarose suspension and in solid substrate. Some of these clones became partially responsive to GC, when compared to the ST1 cell line. Co-immunoprecipitation assays revealed some differences in the SWI/SNF complex between ST1 and P7 cells.
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Yang, Eric Vincent. "Modulation of the extracellular matrix proteins ST1 and MT2 during limb regeneration in two urodele amphibians, the newt, Notophthalmus viridescens, and the axolotl, Ambystoma mexicanum /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487841548268774.

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Cheung, Ka-chun. "Role of matriptase (ST14) in chronic myeloid leukaemia." Thesis, 2014. http://hdl.handle.net/2440/85926.

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Chronic myeloid leukaemia (CML) is characterised by a reciprocal chromosomal translocation that gives rise to a 22q-, or Philadelphia (Ph) chromosome and a derivative 9+. The translocation results in a chimaeric BCR-ABL gene which is expressed as a 210 kDa protein. The tyrosine kinase inhibitor imatinib mesylate (IM) specifically blocks the enzymatic activity of the BCR-ABL fusion protein and has been successfully employed for the treatment of CML. However, some patients develop resistance to IM and progress to blastic crisis (BC) which is usually fatal. Previous microarray screening of murine cell clones ectopically expressing graded amounts of BCR-ABL showed that ST14 mRNA levels correlated with those of BCR-ABL. ST14, encoding matriptase, acts as a tumour suppressor gene in solid tumours, but has also been linked to metastasis and invasion. The aim of my project is to understand the function of ST14 in CML. Taqman real time quantitative PCR showed that there was downregulation of ST14 expression in CD34 cells from CML chronic phase (CP) as compared to those from healthy individuals. These findings were further confirmed by experiments demonstrating upregulation of ST14 expression in Ph-pos cell lines upon IM treatment, a phenomenon not observed in Ph-neg lines. In order to study the effect of ST14 overexpression in CML cell lines, a retroviral vector encoding ST14 was used to infect Ph-pos cell lines (i.e. K562, KCL22 and LAMA84). Overexpression of ST14 in CML cell lines and primary cells significantly enhanced their migratory and invasion capacities. Intriguingly, it restored IM sensitivity in the KCL22 cell line which is intrinsically resistant to IM. The rescue of IM sensitivity in KCL22 overexpressing ST14 was independent of the level of BCR-ABL expression and unrelated to intracellular IM uptake, LYN and MET expression. The increased sensitivity to IM of KCL22 overexpressing ST14 was found to be associated with downregulation of BCL2 expression, a pro-survival protein. Furthermore, the analysis of ST14 expression in a group of IM treated CML CP patients from a clinical trial showed that a lower ST14 expression was associated with poorer molecular responses. The ST14 percentage at baseline was found to be a better predictor of achieving complete cytogenetic response (CCyR) at 12 months than the Sokal score. Overall, our findings were consistent with a tumour suppressor role for ST14. Future studies should focus on delineating the role of ST14 as a prognostic indicator in CML patients and its role in the mechanism of disease progression as well as IM resistance.
Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2014
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Books on the topic "ST14"

1

Senior, Jayne Gillian. Linkage analysis of families with the fragile X syndrome, using the DNA probes F9 and ST14. Birmingham: University of Birmingham, 1987.

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author, Sritharan Kaji, ed. Secrets of success: Getting the most out of your ST1-ST3 years. [Boca Raton]: CRC Press, 2012.

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author, Raechlords Kc. Gayla St1. Primedia eLaunch LLC, 2017.

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ASS, NATIONAL. Statements Mngnt Accountng(st4. NYIF, 1991.

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Autolire CD ROM Key ST4. Collins Educational, 1993.

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Solid Edge ST4 for Designers. CADCIM Technologies, 2012.

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KC, Raechlord. Gayla St1: Wind of Change. Independently Published, 2018.

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Graves, Sue. Jumpstart ST1 Set B Bk6 Boxes. Collins Educational, 1999.

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Jumpstart ST1 Setb Big Bad Bull. Collins Educational, 1999.

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Graves, Sue. Jumpstart ST1 Seta Bk4 the Sandpit. Collins Educational, 1999.

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Book chapters on the topic "ST14"

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Friis, Stine. "Matriptase (ST14, Suppressor of Tumorigenicity 14 Protein)." In Encyclopedia of Signaling Molecules, 2989–96. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101517.

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Friis, Stine. "Matriptase (ST14, Suppressor of Tumorigenicity 14 Protein)." In Encyclopedia of Signaling Molecules, 1–7. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101517-1.

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Cao, Sheng Quan, Jin Xu Zhang, Jian Sheng Wu, and Jia Guang Chen. "Effect of Local Texture on the Orange Peel Defect in St14 Steel Sheet." In Materials Science Forum, 167–72. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-975-x.167.

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Shobeiri, Parnian, and Nima Rezaei. "STK4 Deficiency." In Genetic Syndromes, 1–3. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-66816-1_102-1.

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Caldas, Felipe, Thiago Nascimento Figueiredo, Antônio Lima Júnior, Edílson Ferneda, Lourdes Brasil, and Fernando Azevedo. "STI4-RT: A Support Environment for Teaching Thoracic Radiology." In World Congress on Medical Physics and Biomedical Engineering 2006, 3850–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-36841-0_974.

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Iturrate, Mikel, Xabier Amezua, Xabier Garikano, Jose Antonio Oriozabala, Iñaki Martin, and Eneko Solaberrieta. "Generative Design in the Transmission System of a Skateboard." In Lecture Notes in Mechanical Engineering, 169–74. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-70566-4_27.

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AbstractGenerative design (GD) is a new way of designing products that respond to the current characteristics of the 4.0 industry era. It allows the customization of designs and helps to minimize process times and material quantities. In the case study, two parts of the transmission system of a skateboard have been designed using GD of Solid Edge ST10. The design has been customized for 67 kg users who will use the skateboard for riding and not for jumping or doing tricks. On the other hand, the aim was to minimize the weight and the use of material for its manufacture. Once the initial solid is defined, the software generates specific designs for different levels of mass reduction or product quality. An axle with a mass reduction of 70% from the initial solid and a base with reduction of 60% have been proposed. The GD more than an alternative is a requirement to respond to the demands of the 4.0 industry in which customization and cost reduction are one of the fundamental pillars. This type of design, at the same time, forces to adapt the manufacturing processes so that it is necessary to manufacture in additive manufacturing (AM) machines.
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Baenziger, Jacques U. "N-Acetylgalactosamine-4-sulfotransferase-1 (GalNAc-4-ST1, CHST8) and N-Acetylgalactosamine-4-sulfotransferase-2 (GalNAc-4-ST2, CHST9)." In Handbook of Glycosyltransferases and Related Genes, 1149–55. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54240-7_5.

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"Serine/Threonine Kinase 4 (STK4)." In Encyclopedia of Medical Immunology, 587. New York, NY: Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4614-8678-7_300319.

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"1st Serve." In Sports Success Rx, 11–24. American Academy of Pediatrics, 2006. http://dx.doi.org/10.1542/9781581105391-st1.

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Meijer, R. J. "THE STM4-120 STIRLING ENGINE FOR SOLAR APPLICATIONS." In Advances In Solar Energy Technology, 1390–95. Elsevier, 1988. http://dx.doi.org/10.1016/b978-0-08-034315-0.50270-6.

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Conference papers on the topic "ST14"

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Moslemi, M., S. J. Hosseinipour, M. E. Hosseini, and A. H. Gorji. "A Comparison between Three Numerical Criteria for Prediction the Forming Limit Diagram of St14 Steel." In THE 8TH INTERNATIONAL CONFERENCE AND WORKSHOP ON NUMERICAL SIMULATION OF 3D SHEET METAL FORMING PROCESSES (NUMISHEET 2011). AIP, 2011. http://dx.doi.org/10.1063/1.3623608.

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Suzuki, N., A. Iizuka, T. Nagao, Y. Nakahori, M. Yamada, and Y. Nakagome. "CARRIER DETECTION OF HEMOPHILIA A BY DNA ANALYSIS IN AFFECTED JAPANESE FAMILIES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644008.

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Several DNA probes have been isolated to detect Factor VIII gene and a DNA segment which locates veryclose to the gene. They have been successfully used to detect carriers and patients of hemophilia A.We analyzed DNA samples of Japanese population to see whether these probesare also useful for carrier detection of hemophilia A in affected Japanese families, since the size and frequency of allelic fragments detected by a DNA probe are sometimes different in various ethnic groups.A probe of St14 (DXS52) is thought to be one of the best probes for such analysis in Caucasian population because it detects very polymorphic DNA fragments containing a minisatellite. When Taq I digests of Japanese DNA samples were hybridized with Stl4, several DNA fragments with a range from 1.7 kb to 5-5 kb were detected, where .at least 6 fragments were polymorphic. A notable difference between Japanese and Caucasian was that a band of 5-5 kb was variable in Japanese while it was constant in Caucasian. We have so far detected 10 alleles, and about 60% of Japanese women were heterozygous. Using these informationsabout Japanese population, we could detect carriers in several families. Other RFLPs data are necessary to increase information content. Similar studies arein progress using different probes i.e. an extragenic probe ; DX13/Bgl II, and two intragenic probes ; exon 14-26/Bcl I and exon 26/Bgl I. We thank Mandel J.L., Strasbourg, Davies K., Oxford and Genetics Institute, Cambridge for probes.
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Pouranvari, M., S. P. H. Marashi, S. M. Mousavizadeh, Francisco Chinesta, Yvan Chastel, and Mohamed El Mansori. "The Effect of Welding Parameters on the Tensile-Shear Performance of Dissimilar DP600∕St14 Resistance Spot Welds." In INTERNATIONAL CONFERENCE ON ADVANCES IN MATERIALS AND PROCESSING TECHNOLOGIES (AMPT2010). AIP, 2011. http://dx.doi.org/10.1063/1.3552554.

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Godett, T. M., R. J. Meijer, R. P. Verhey, C. J. Pearson, and K. Khalili. "STM4-120 Stirling Engine Test Development." In SAE International Congress and Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1989. http://dx.doi.org/10.4271/890149.

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Gauthier, Lovic, and Ahmed Amine Jerraya. "Cycle-true simulation of the ST10 microcontroller (poster paper)." In the conference. New York, New York, USA: ACM Press, 2000. http://dx.doi.org/10.1145/343647.344125.

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Staley, Spencer E., Peter J. Fawcett, R. Scott Anderson, Gonzalo Jimenez-Moreno, and Michael Petronis. "CORE STL14: RECORDING PALEOCLIMATES SINCE THE EARLY PLEISTOCENE IN SOUTHWESTERN NORTH AMERICA." In GSA Annual Meeting in Phoenix, Arizona, USA - 2019. Geological Society of America, 2019. http://dx.doi.org/10.1130/abs/2019am-337895.

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Zeleneva J.V., J. V., and V. P. Sudnikova V.P. "Characteristic of the zimoseptoria tritici population by virulence in the of the Central Black Soil region of Russia." In Растениеводство и луговодство. Тимирязевская сельскохозяйственная академия, 2020. http://dx.doi.org/10.26897/978-5-9675-1762-4-2020-16.

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Based on the analysis of the intraspecific structure of the fungus Zimoseptoria. tritici, it was found that this species has significant polymorphism. Using monogenic wheat lines (Oasis (Stb1), Veranopolis (Stb2), Israel (Stb3), Tadinia (Stb4), CS / Synthetic (Stb5), Estanzuela Federal (Stb7)), the population of Z. tritici in the Central Black Earth region was tested. High heterogeneity of monosporous isolates of Z. tritici by virulence was revealed.
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Khataei, Mohammad, Mehrdad Poursina, Mahmoud Kadkhodaei, F. Barlat, Y. H. Moon, and M. G. Lee. "A Study on Fracture Locus of St12 Steel And Implementation Ductile Damage Criteria." In NUMIFORM 2010: Proceedings of the 10th International Conference on Numerical Methods in Industrial Forming Processes Dedicated to Professor O. C. Zienkiewicz (1921–2009). AIP, 2010. http://dx.doi.org/10.1063/1.3457533.

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Bernardi, F., G. Marchetti, F. Vannini, L. Felloni, F. Panicucci, and F. Conconi. "SPORADISM INVESTIGATION AND CARRIER DETECTION IN HAEMOPHILIA A BY RFLP ANALYSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644011.

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Restriction fragment lenght polymorphisms (RFLPs)analysis has been employed for carrier detection andfor sporadism study in Haemophilia A. Three RFLPs, one intragenic in FC8 (647/BcII) and two with close linkage to Haemophilia A at DXS52 (Stl4/Taql) and DXS15 (DX13/BgIII), were used.In 20 families 29 carrier status determinations havebeen performed.In order to investigate sporadicity and to estimate the sex ratio of mutation rates directely, 17 families with isolated cases of haemophilia A were studied.In eight out of the 17 families the RFLPsanalysis excluded the carrier status of the maternalgrandmothers.Since by hemostatic studies the eight mothers of the propositi were shown to be haemophilia carriers, the origin of the newly mutated genes was inferred from the RFLP patterns: six haemophilic genes derive from the normal maternal grandfathers and two from the maternal grandmothers.Possible recombinations between FVIII locus and the extragenic RFLPs loci have to be considered; however the intragenic Bell RFLP is informative in five out of the eight families and the DXl3 and Stl4 patterns are concordant.The data indicate a higher mutation rate in males than in females gametes as previously suggested, althought not unanimously, by segregation analysis and coagulation studies. The RFLP analysis in a large number of families with isolated cases of haemophilia isnecessary to define the precise ratio of sex mutation rate for this disease.Work supported by P.F. Ing. Gen. Basi Mol. Mai. Ered. Contratto CNR N 8400877.
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Alziadeh, Mohammed, Atef Mohany, and Marwan Hassan. "Effect of Flow Approach Angle on Acoustic Resonance Excitation of In-Line Tube Bundles in Cross-Flow." In ASME 2019 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/pvp2019-93445.

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Abstract This paper presents preliminary experimental results on the influence of the flow approach angle on the acoustic resonance excitation of in-line tube bundles in cross-flow. The pitch-to-diameter ratio (P/D) of the in-line tube bundles investigated is P/D = 1.733. The flow approach angle was investigated by physically rotating the tube bundle clockwise relative to the flow direction. The tube bundles are capable of rotating with increments of 5° up to an angle of 45°. For brevity, only the results for the 0° and 30° orientation will be presented herein. For the 0° orientation, two Strouhal frequencies (St1 = 0.437 and St2 = 0.252) were observed. However, only one of these frequencies (St1 = 0.437) was capable of exciting resonance. During resonance, a peak sound pressure level (SPL) of 170 dB was achieved. The Strouhal frequencies and peak SPL agrees well with what has been presented in the literature. For the 30° orientation, only one Strouhal frequency (St1 = 0.98) was measured. At this orientation, the lock-in phenomenon occurred at a much lower flow velocity compared to the 0° orientation with a peak SPL reaching 153 dB. Jumps in the lock-in frequency were observed at the 30° orientation. This phenomenon is associated with two reasons. The first reason is a partial lock-in with an acoustic resonant mode, due to the acoustic energy not being fully trapped within the tube bundle. The second reason is related to the changes in the apparent speed of sound resulting in variations in the acoustic cross-mode frequency depending on where the excitation source is emanating from within the tube bundle. A brief summary of the results is presented in this paper.
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Reports on the topic "ST14"

1

Highland, J. D. Bioventing Pilot Test Final Report Site ST14, Fuel Loading Area, Carswell AFB, Texas. Fort Belvoir, VA: Defense Technical Information Center, August 1993. http://dx.doi.org/10.21236/ada384807.

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PARSONS ENGINEERING SCIENCE INC DENVER CO. Redmedial Action Plan for the Risk-Based Remediation of Site ST14 (SWMU 68), LPSTID 104819; the Former Base Refueling Area (A0C7); the French Underdrain System (SWMU 64); and the North Oil/Water Separator (SWMU 67), Carswell Air Force Base, Naval Air Station Fort Worth Joint Reserve Base, Texas. Volume 1: Report. Fort Belvoir, VA: Defense Technical Information Center, July 1997. http://dx.doi.org/10.21236/ada381545.

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Rawlinson, K., and D. Adkins. Design, fabrication, and testing of a sodium evaporator for the STM4-120 kinematic Stirling engine. Office of Scientific and Technical Information (OSTI), May 1995. http://dx.doi.org/10.2172/90241.

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PARSONS ENGINEERING SCIENCE INC DENVER CO. Treatability Study in Support of Intrinsic Remediation for Site ST41. Elmendorf Air Force Base, Anchorage, Alaska. Fort Belvoir, VA: Defense Technical Information Center, October 1995. http://dx.doi.org/10.21236/ada286949.

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Linker, K. L., K. S. Rawlinson, and G. Smith. Characteristics, finite element analysis, test description, and preliminary test results of the STM4-120 kinematic Stirling engine. Office of Scientific and Technical Information (OSTI), October 1991. http://dx.doi.org/10.2172/5976158.

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