Journal articles: 'SSLOD'

1

Kury, P., T. Grabosch, and M. Horn-von Hoegen. "SSIOD: The next generation." Review of Scientific Instruments 76, no. 2 (February 2005): 023903. http://dx.doi.org/10.1063/1.1844191.

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Vial, Thierry, Jacqueline Pont, Emmanuel Pham, Muriel Rabilloud, and Jacques Descotes. "Cefaclor-Associated Serum Sickness-Like Disease: Eight Cases and Review of the Literature." Annals of Pharmacotherapy 26, no. 7-8 (July 1992): 910–14. http://dx.doi.org/10.1177/106002809202600708.

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OBJECTIVE: To describe the clinical features of serum sickness-like diseases (SSLD) in cefaclor-treated patients. DESIGN: Analysis of a case series spontaneously reported to Lyons Pharmacovigilance Center. SETTING: General and hospital practitioners and the French Network of Regional Pharmacovigilance Centers (FNRPC). PATIENTS: All reported cases with a possible causative relationship between cefaclor treatment and SSLD. MAIN RESULTS: Eight cases of SSLD following cefaclor treatment are described. The clinical features included cutaneous reactions, arthralgias, and moderate hyperthermia. In 50 percent of the patients, hospitalization was required because of incapacitating symptoms. The outcome was benign in all cases following discontinuation of the offending drug. All eight cases were reported in children under five years of age. Among 137 cefaclor-associated drug reactions collected by FNRPC, 27 cases of SSLD have been reported; 23 of these patients were younger than five years of age. A literature survey confirmed the higher reporting of SSLD in children with cefaclor compared with other antibiotics and suggested an incidence of 0.024–0.2 percent of SSLD per drug course of cefaclor. CONCLUSIONS: The case reports and epidemiologic studies confirmed the presumed role of age (patients under five years of age) in cefaclor-induced SSLD and the benign outcome despite severe clinical presentations in some reports.

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Pawlowski, A., M. Beschi, J. L. Guzmán, A. Visioli, M. Berenguel, and S. Dormido. "Application of SSOD-PI and PI-SSOD event-based controllers to greenhouse climatic control." ISA Transactions 65 (November 2016): 525–36. http://dx.doi.org/10.1016/j.isatra.2016.08.008.

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Loyo-Maldonado, Valent�n, and Ren� De J. Romero-Troncoso. "Interactive tool in silicon semiconductor modeling: SSMod." Computer Applications in Engineering Education 6, no. 2 (1998): 59–65. http://dx.doi.org/10.1002/(sici)1099-0542(1998)6:2<59::aid-cae1>3.0.co;2-z.

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Kumar, Monu, Mukul Panwar, and Sanjay Bhargava. "Simple Sequence Oriented Disk (SSOD) Scheduling Algorithm." International Journal of Computer Applications 100, no. 2 (August 20, 2014): 20–24. http://dx.doi.org/10.5120/17497-8029.

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Ntshangase, Nobuhle C., Olawumi O. Sadare, and Michael O. Daramola. "Effect of Silica Sodalite Functionalization and PVA Coating on Performance of Sodalite Infused PSF Membrane during Treatment of Acid Mine Drainage." Membranes 11, no. 5 (April 26, 2021): 315. http://dx.doi.org/10.3390/membranes11050315.

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In this study, silica sodalite (SSOD) nanoparticles were synthesized by topotactic conversion and functionalized using HNO3/H2SO4 (1:3). The SSOD and functionalized SSOD (fSSOD) nanoparticles were infused into a Polysulfone (Psf) membrane to produce mixed matrix membranes. The membranes were fabricated via the phase inversion method. The membranes and the nanoparticles were characterized using Scanning Electron Microscopy (SEM) to check the morphology of the nanoparticles and the membranes and Fourier Transform Infrared to check the surface chemistry of the nanoparticles and the membranes. Thermal stability of the nanoparticles and the membranes was evaluated using Themogravimetry analysis (TGA) and the degree of hydrophilicity of the membranes was checked via contact angle measurements. The mechanical strength of the membranes and their surface nature (roughness) were checked using a nanotensile instrument and Atomic Force Microscopy (AFM), respectively. The textural property of the nanoparticles were checked by conducting N2 physisorption experiments on the nanoparticles at 77 K. AMD-treatment performance of the fabricated membranes was evaluated in a dead-end filtration cell using a synthetic acid mine drainage (AMD) solution prepared by dissolving a known amount of MgCl2, MnCl2·4H2O, Na2SO4, Al(NO3)3, Fe(NO3)3·9H2O, and Ca2OH2 in deionized water. Results from the N2 physisorption experiments on the nanoparticles at 77 K showed a reduction in surface area and increase in pore diameter of the nanoparticles after functionalization. Performance of the membranes during AMD treatment shows that, at 4 bar, a 10% fSSOD/Psf membrane displayed improved heavy metal rejection >50% for all heavy metals considered, expect the SSOD-loaded membrane that showed a rejection <13% (except for Al3+ 89%). In addition, coating the membranes with a PVA layer improved the antifouling property of the membranes. The effects of multiple PVA coating and behaviour of the membranes during real AMD are not reported in this study, these should be investigated in a future study. Therefore, the newly developed functionalized SSOD infused Psf membranes could find applications in the treatment of AMD or for the removal of heavy metals from wastewater.

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Nedaei, Maryam, Ali Reza Zarei, and Sohrab Ali Ghorbanian. "Development of a new emulsification microextraction method based on solidification of settled organic drop: application of a novel ultra-hydrophobic tailor-made deep eutectic solvent." New Journal of Chemistry 42, no. 15 (2018): 12520–29. http://dx.doi.org/10.1039/c8nj02219d.

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In this research, a new microextraction method based on the solidification of settled organic drop (SSOD) was developed by coupling a novel tailor-made ultra-hydrophobic deep eutectic solvent (DES) with effervescence assisted emulsification microextraction.

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Iurian, Sorin Ioan, Livia Ognean, Han Brunner, Leo Kluijtmans, Petr Jira, Dana Fîntînă, and Bogdan Ionuţ Mehedinţu. "SINDROMUL SMITH-LEMLI-OPITZ. PREZENTARE DE CAZ." Romanian Journal of Pediatrics 64, no. 1 (March 31, 2015): 70–73. http://dx.doi.org/10.37897/rjp.2015.1.15.

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Sindromul Smith-Lemli-Opitz (SSLO) reprezintă o afecţiune cu transmitere autozomal-recesivă caracterizată prin multiple anomalii şi care se datorează anomaliilor în sinteza colesterolului. Autorii prezintă particularităţile diagnostice şi terapeutice la un sugar cu ambiguitate genitală.

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Gu, W., and N. R. Hecht. "Translation of a testis-specific Cu/Zn superoxide dismutase (SOD-1) mRNA is regulated by a 65-kilodalton protein which binds to its 5' untranslated region." Molecular and Cellular Biology 16, no. 8 (August 1996): 4535–43. http://dx.doi.org/10.1128/mcb.16.8.4535.

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Mouse testes contain two distinct superoxide dismutase (SOD-1) transcripts which differ by 114 nucleotides in their 5' untranslated regions (UTRs) (W. Gu, C. Morales, and N. B. Hecht, J. Biol. Chem. 270:236-243, 1995). The shorter SOD-1 mRNA, a somatic type SOD-I mRNA (SSOD-1), is ubiquitously expressed in all somatic tissues as well as in testes. The larger SOD-1 mRNA, a testis-specific SOD-1 mRNA (TSOD-1), derived from an alternative upstream start site, is transcribed solely in postmeiotic germ cells and is translationally regulated during spermiogenesis. Since the two mRNAs have identical nucleotides except that TSOD-1 has an additional sequence at its 5' terminus, we have proposed that the extra 5' UTR sequence may be involved in the translational control of the TSOD-1 mRNA during spermiogenesis. Here we show that, when assayed in a cell-free system, TSOD-1 is translated only slightly less efficiently than SSOD-1. RNA gel retardation and UV cross-linking assays reveal that a testicular cytoplasmic protein (Cu/Zn superoxide dismutase RNA-binding protein [SOD-RBP]) of about 65 kDa specifically binds to the extended 5' UTR of TSOD-1. After purification of SOD-RBP by RNA affinity chromatography, we demonstrate that SOD-RBP can repress the in vitro translation of TSOD-1 mRNA but not SSOD-1 mRNA or cotranslated luciferase mRNA. We conclude that SOD-RBP serves as a repressor in the translation of TSOD-1 mRNA during spermiogenesis and thereby fine-tunes the level of Cu/Zn superoxide dismutase produced in maturing germ cells.

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Hantel, Constanze, Felicitas Lewrick, Martin Reincke, Regine Süss, and Felix Beuschlein. "Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma." Journal of Endocrinology 213, no. 2 (March 9, 2012): 155–61. http://dx.doi.org/10.1530/joe-11-0427.

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Adrenocortical carcinoma (ACC) is a rare endocrine tumor entity with poor prognosis. Medical treatment is limited to common cytotoxic agents, which are associated with low treatment responses. Thus, lack of therapeutic efficacy demands innovative treatment options for patients with advanced ACC. Recently, we have developed and characterized anti-IGF1 receptor (IGF1-R) immunoliposomes (SSLD-1H7) for the treatment of neuroendocrine tumors of the gastroenteropancreatic system. As previous results indicated putative applicability also for other IGF1-R-overexpressing tumor entities, we initiated testing of liposomal preparations in in vitro and in vivo models of ACC. Adrenocortical NCIh295 cells were used for in vitro association studies with different liposomal formulations. Thereby, flow cytometry revealed high cellular association and internalization of anti-IGF1-R immunoliposomes (soy phosphatidylcholine (SPC)/cholesterol (Chol)–polyethyleneglycol (PEG)-1H7, 50.1±2.2%). Moreover, internalization of pegylated liposomes (SPC/Chol–PEG, 57.1±2.4%) and an even higher uptake of plain liposomes (84.6±0.8%; P<0.0001) were detectable in adrenocortical tumor cells. In vivo, liposomal treatments were investigated on NCIh295 tumor xenografts in pharmacokinetic and therapeutic experiments. A significant reduction in tumor size was detectable in NCIh295 tumor-bearing mice after a single treatment with SSLD-1H7 (0.89±0.15 cm; P=0.006) and a diminished efficacy for SSLD–PEG+ (1.01±0.19 cm; P=0.04) in comparison with untreated controls (1.5±0.0 cm). Thus, anti-IGF1-R immunoliposomes have been successfully tested in vitro and in vivo in a preclinical model for ACCs and could, therefore, represent a promising therapeutic approach for this tumor entity. Moreover, a combination of mitotane plus liposomally encapsulated cytostatic agents instead of free drugs could also be an interesting novel treatment option for ACC in the future.

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Ngobeni, Rivoningo, Olawumi Sadare, and Michael O. Daramola. "Synthesis and Evaluation of HSOD/PSF and SSOD/PSF Membranes for Removal of Phenol from Industrial Wastewater." Polymers 13, no. 8 (April 13, 2021): 1253. http://dx.doi.org/10.3390/polym13081253.

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Phenol is regarded as a major pollutant, as the toxicity levels are in the range of 9–25 mg/L for aquatic life and humans. This study embedded silica sodalite (SSOD) and hydroxy sodalite (HSOD) nanoparticles into polysulfone (PSF) for enhancement of its physicochemical properties for treatment of phenol-containing wastewater. The pure polysulfone membranes and sodalite-infused membranes were synthesized via phase inversion. To check the surface morphology, surface hydrophilicity, surface functionality, surface roughness and measure the mechanical properties of the membranes, characterization techniques such as Scanning Electron Microscope (SEM), contact angle measurements, Fourier Transform Infrared, Atomic Force Microscopy (AFM) nanotensile tests were used, respectively. The morphology of the composite membranes showed incorporation of the sodalite crystals decreased the membrane porosity. The results obtained showed the highest contact angle of 83.81° for pure PSF as compared to that of the composite membranes. The composite membranes with 10 wt.% HSOD/PSF and 10 wt.% SSOD/PSF showed mechanical enhancement as indicated by a 20.96% and 19.69% increase in ultimate tensile strength, respectively compared to pure PSF. The performance evaluation of the membranes was done using a dead-end filtration cell at varied feed pressure. Synthetic phenol-containing wastewater was prepared by dissolving one gram of phenol crystals in 1 L of deionized water and used in this study. Results showed higher flux for sodalite infused membranes than pure PSF for both pure and phenol-containing water. However, pure PSF showed the highest phenol rejection of 93.55% as compared to 63.65% and 64.75% achieved by 10 wt.% HSOD/PSF and 10 wt.% SSOD/PSF, respectively. The two sodalite infused membranes have shown enhanced mechanical properties and permeability during treatment of phenol in synthetic wastewater.

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Wang, Xiang Hua. "Real-Time Prediction of Debris Flow Using Fuzzy Event Tree Based on Dynamic Process Factors in GIS." Advanced Materials Research 1010-1012 (August 2014): 1262–66. http://dx.doi.org/10.4028/www.scientific.net/amr.1010-1012.1262.

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Debris flow is a kind of serious geologic hazard and Real-time prediction of debris flow is essential for the protection of human life and property. The objective of this paper is to propose a method for real-time predicting debris flow using fuzzy event tree (FET), which is constructed by integrating event tree analysis, fuzzy mathematics and expert knowledge. Xiu Yan County, An Shan City, Liaoning province in China was used as a case. The prediction assessment was based on four dynamic process factors, namely antecedent rainfall (AR), the maximum rainfall intensity (MRI) each hour, soil saturated liquefaction degree (SSLD) and soil instability (SI). The four dynamic process factors were viewed as initiating events in FET model for forecasting debris flow. The result indicated that the majority of study area is characterized by medium and low dangerous level. This study suggests that weather forecast, timely detection of SSLD and SI are important for preventing and mitigating disaster and FET methodology is promising for real-time foresting geologic hazard.

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Zen, Nobuyuki, Koji Suzuki, Shigetomo Shiki, Masahiro Ukibe, Alessandro Casaburi, Mikkel Ejrnaes, Roberto Cristiano, and Masataka Ohkubo. "Operation of superconducting nano-stripline detector (SSLD) mounted on cryogen-free cryostat." Physics Procedia 27 (2012): 356–59. http://dx.doi.org/10.1016/j.phpro.2012.03.484.

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Leong, SPL, I. Steinmetz, K. Abbey, T. Achten, S. Stuntebeck, A. McMillan, R. Allen, et al. "Patterns of recurrence in primary malignant melanoma following selective sentinel lymph node dissection (SSLND)." Melanoma Research 7, Supplement 1 (June 1997): S11. http://dx.doi.org/10.1097/00008390-199706001-00036.

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Thombs, Brett D., Laura Dyas, Mia Pépin, Kylene Aguila, Marie-Eve Carrier, Lydia Tao, Sami Harb, et al. "Scleroderma Patient-centered Intervention Network—Scleroderma Support group Leader EDucation (SPIN-SSLED) program: non-randomised feasibility trial." BMJ Open 9, no. 11 (November 2019): e029935. http://dx.doi.org/10.1136/bmjopen-2019-029935.

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ObjectivesThe Scleroderma Patient-centered Intervention Network—Scleroderma Support group Leader EDucation (SPIN-SSLED) Programme was designed to improve confidence and self-efficacy and to reduce burden for support group leaders. Objectives were to (1) evaluate feasibility of programme delivery, including required resources, management issues and scientific aspects (eg, performance of outcome measures) and (2) assess user satisfaction and identify any modifications needed to improve programme content or delivery based on participant feedback.DesignNon-randomised feasibility trial.SettingNorth American patient organisations.ParticipantsCurrent support group leaders or potential new leaders referred by patient organisations.InterventionThe programme included 13 modules delivered live via videoconference over 3 months (April to July 2018) in 60 to 90 min sessions.Outcome measures(1) Elements of feasibility, including enrolment and consent procedures, percentage of referred group leaders who consented to participate, session attendance and technical support requirements; (2) programme usability, understandability, organisation and clarity; (3) leader satisfaction with the programme and (4) planned trial outcome measures, including support group leader self-efficacy, burnout, emotional distress and physical function.ResultsAll 12 referred potential participants consented to enrol, and 10 were included in two training groups of five participants each. Participants attended 95% of sessions. Required technical support was minimal, and videoconferencing technology functioned well. Overall programme satisfaction rating was 9.4/10. Mean item rating on the eight items of the Client Satisfaction Questionnaire-8 was 3.83 (1=low satisfaction; 4=high satisfaction). Pre-post scores on the Scleroderma Support Group Leader Self-efficacy Scale increased by 1.7 SDs (large effect); scores on burnout, emotional distress and physical function improved by 0.44, 0.38 and 0.45 SDs (moderate effects).ConclusionThe SPIN-SSLED Programme was feasibly delivered, including management, resource and scientific aspects. Participant satisfaction was high. The programme is ready to be tested in a full-scale randomised controlled trial.Trial registration numberNCT03508661

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Zen, N., K. Suzuki, S. Shiki, and M. Ohkubo. "Niobium superconducting strip line detectors (SSLD) for time-of-flight mass spectroscopy (TOF-MS)." Physica C: Superconductivity 469, no. 15-20 (October 2009): 1684–87. http://dx.doi.org/10.1016/j.physc.2009.05.044.

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Pachauri, Rahul, Rajiv Saxena, and Sanjeev N. Sharma. "Studies on Z-Window Based FIR Filters." ISRN Signal Processing 2013 (September 1, 2013): 1–8. http://dx.doi.org/10.1155/2013/148646.

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As per classification of the window functions, the Z-windows are grouped in the category of steerable side-lobe dip (SSLD) windows. In this work, the application of these windows for the design of FIR filters with improved filter parameters has been explored. The numbers of dips with their respective positions in the side-lobe region have been compositely used to tailor the window shape. Filter design relationships have been established and included in this paper. Simultaneously, an application of these Z-window based FIR filters in designing two-channel quadrature mirror filter (QMF) bank has been presented. Better values of reconstruction and aliasing errors have been achieved in contrast to the Kaiser window based QMF bank.

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Jeffrey, M., G. McGovern, N. Makarava, L. González, Y. S. Kim, R. G. Rohwer, and I. V. Baskakov. "Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies." Neuropathology and Applied Neurobiology 40, no. 3 (March 13, 2014): 296–310. http://dx.doi.org/10.1111/nan.12053.

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Kaviris, G., I. Spingos, V. Kapetanidis, and P. Papadimitriou. "PRELIMINARY SHEAR-WAVE SPLITTING RESULTS IN THE BROADER AIGION AREA (GREECE) DURING 2013." Bulletin of the Geological Society of Greece 50, no. 3 (July 27, 2017): 1153. http://dx.doi.org/10.12681/bgsg.11821.

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An anisotropic upper crust has been revealed in the W. Gulf of Corinth with potentially changing properties. During 2013, a unique opportunity to conduct a shear-wave analysis was presented, as a combination of the significantly increased seismicity in the area, including a seismic swarm between May and August, and the existence of local seismological networks. The Hellenic Unified Seismological Network (HUSN) and the Corinth Rift Laboratory Network (CRLN) provided invaluable data during the unrest period. While shear-waves travel through an anisotropic medium, the splitting phenomenon takes place and, as a result, their propagation is characterized by two discernible components: the fast (Sfast) and the slow (Sslow) one, which arrives to the station in a subsequent temporal point. Modern advances in seismology and geophysics have rendered shear-wave splitting a valuable tool in determining properties of the anisotropic propagation media. One of the predominant causes of this phenomenon is the existence of microcracks throughout the upper crust. The current study presents results for 8 stations from 535 analyzed events that are in agreement with the anisotropy models of EDA and APE.

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Konstantinopoulos, D., D. Giannopoulos, E. Sokos, K. I. Konstantinou, and G. A. Tselentis. "THE CRUSTAL ANISOTROPY PATTERN IN THE EPICENTRAL AREA OF THE 2008 MW 6.4 EARTHQUAKE IN NORTHWEST PELOPONNESE, GREECE." Bulletin of the Geological Society of Greece 50, no. 3 (July 27, 2017): 1174. http://dx.doi.org/10.12681/bgsg.11823.

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An anisotropic upper crust has been revealed in the W. Gulf of Corinth with potentially changing properties. During 2013, a unique opportunity to conduct a shear-wave analysis was presented, as a combination of the significantly increased seismicity in the area, including a seismic swarm between May and August, and the existence of local seismological networks. The Hellenic Unified Seismological Network (HUSN) and the Corinth Rift Laboratory Network (CRLN) provided invaluable data during the unrest period. While shear-waves travel through an anisotropic medium, the splitting phenomenon takes place and, as a result, their propagation is characterized by two discernible components: the fast (Sfast) and the slow (Sslow) one, which arrives to the station in a subsequent temporal point. Modern advances in seismology and geophysics have rendered shear-wave splitting a valuable tool in determining properties of the anisotropic propagation media. One of the predominant causes of this phenomenon is the existence of microcracks throughout the upper crust. The current study presents results for 8 stations from 535 analyzed events that are in agreement with the anisotropy models of EDA and APE.

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Qiang, Baohua, Ruidong Chen, Mingliang Zhou, Yuanchao Pang, Yijie Zhai, and Minghao Yang. "Convolutional Neural Networks-Based Object Detection Algorithm by Jointing Semantic Segmentation for Images." Sensors 20, no. 18 (September 7, 2020): 5080. http://dx.doi.org/10.3390/s20185080.

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In recent years, increasing image data comes from various sensors, and object detection plays a vital role in image understanding. For object detection in complex scenes, more detailed information in the image should be obtained to improve the accuracy of detection task. In this paper, we propose an object detection algorithm by jointing semantic segmentation (SSOD) for images. First, we construct a feature extraction network that integrates the hourglass structure network with the attention mechanism layer to extract and fuse multi-scale features to generate high-level features with rich semantic information. Second, the semantic segmentation task is used as an auxiliary task to allow the algorithm to perform multi-task learning. Finally, multi-scale features are used to predict the location and category of the object. The experimental results show that our algorithm substantially enhances object detection performance and consistently outperforms other three comparison algorithms, and the detection speed can reach real-time, which can be used for real-time detection.

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Wang, Jung-Chang. "Analyzing Thermal Module Developments and Trends in High-Power LED." International Journal of Photoenergy 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/120452.

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The solid-state light emitting diode (SSLED) has been verified as consumer-electronic products and attracts attention to indoor and outdoor lighting lamp, which has a great benefit in saving energy and environmental protection. However, LED junction temperature will influence the luminous efficiency, spectral color, life cycle, and stability. This study utilizes thermal performance experiments with the illumination-analysis method and window program (vapour chamber thermal module, VCTM V1.0) to investigate and analyze the high-power LED (Hi-LED) lighting thermal module, in order to achieve the best solution of the fin parameters under the natural convection. The computing core of the VCTM program employs the theoretical thermal resistance analytical approach with iterative convergence stated in this study to obtain a numerical solution. Results showed that the best geometry of thermal module is 4.4 mm fin thickness, 9.4 mm fin pitch, and 37 mm fin height with the LED junction temperature of 58.8°C. And the experimental thermal resistances are in good agreement with the theoretical thermal resistances; calculating error between measured data and simulation results is no more than ±7%. Thus, the Hi-LED illumination lamp has high life cycle and reliability.

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Uy, Geoffrey L., Michael P. Rettig, Pablo Ramirez, Bruno Nervi, Camille N. Abboud, and John F. DiPersio. "Kinetics of Human and Murine Mobilization of Acute Myeloid Leukemia in Response to AMD3100." Blood 110, no. 11 (November 16, 2007): 867. http://dx.doi.org/10.1182/blood.v110.11.867.867.

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The CXCR4-SDF-1 axis possesses a central role in the trafficking and retention of both normal and malignant stem cells in the bone marrow. Previous work from our laboratory established that in a murine model, a single dose of the CXCR4 antagonist, AMD3100, sensitizes AML blasts to chemotherapy supporting the premise that the interaction between AML blasts and the marrow microenvironment confers resistance to genotoxic stress (Nervi et al., ASH 2006). Here we examine the effects of repetitive dosing of AMD3100 on the kinetics of normal and leukemic mobilization. Following SQ injection of AMD3100 5mg/kg into B6/129 F1 mice daily for 5 days (n=8), we observed a 2.4 fold increase in total leukocyte counts with a 12.4 increase in CFU-GM when compared to 3 hours post injection (Fig 1A). No differences were seen in the degree of mobilization between d1 and d5 with WBC and CFU-GM counts returning to baseline after 24 hours. We next tested repetitive doses of AMD3100 in our mouse model of AML in which 106 blasts derived from leukemic mice carrying the PML-RARα fusion gene in the murine cathepsin G locus are adoptively transferred into genetically compatible secondary recipients. AMD3100 at 5mg/kg was then administered to these AML mice for 4 consecutive days. At 3 hrs post AMD3100 injection, we observed a 1.8 fold increase in peripheral leukocyte counts with a 4.5 fold increase in circulating blasts compared to baseline (n=3). Again, no significant differences are seen in the degree of mobilization from d1 to d4 (Fig 1B). Based on these preclinical data, we have initiated a phase I/II trial of AMD3100 plus mitoxantrone, etoposide and cytarabine (MEC) in relapsed or refractory AML in which AMD3100 is administered 4 hours prior to MEC daily for 5 consecutive days. To study the kinetics of human AML mobilization, we administered AMD3100 by SQ injection followed by 24hr observation period prior to chemotherapy. Two patients have been treated at the first dose level of AMD3100, 80 μg/kg. In pt #1 following AMD3100 mobilization, total WBC increased from 3 × 103/mm3 to a peak of 17 × 103/mm3 at 6 hours post-AMD3100 representing a 5.7 fold increase in total white count (Fig 2). In addition, the blasts (CD45dim, SSlow) increased by 7.3 fold. Similarly in pt #2, we observed a 2 fold increase in the total WBC from 2.5 to 5.1 × 103/mm3 with a 2.3 fold increase in blasts (CD45dim, SSlow). Mobilization of AML was confirmed in both patients through informative FISH for 11q23 (MLL). No adverse events have been observed during mobilization. These data provide the preclinical rationale for repetitive dosing of AMD3100 and direct clinical evidence that AMD3100 mobilizes human AML blasts into the peripheral circulation. Our trial of AMD3100 plus MEC in relapsed or refractory AML is ongoing. Figure 1. AMD3100 induced mobilization of (A) normal progenitors and (B) AML blasts Figure 1. AMD3100 induced mobilization of (A) normal progenitors and (B) AML blasts Figure 2. AMD3100 mobilization of human AML Figure 2. AMD3100 mobilization of human AML

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Aster, Richard C., and Peter M. Shearer. "High-frequency borehole seismograms recorded in the San Jacinto Fault zone, Southern California. Part 1. Polarizations." Bulletin of the Seismological Society of America 81, no. 4 (August 1, 1991): 1057–80. http://dx.doi.org/10.1785/bssa0810041057.

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Abstract Two borehole seismometer arrays (KNW-BH and PFO-BH) have been established in the Southern California Batholith region of the San Jacinto Fault zone by the U.S. Geological Survey. The sites are within 0.4 km of Anza network surface stations and have three-component seismometers deployed at 300 m depth, at 150 m depth, and at the surface. Downhole horizontal seismometers can be oriented to an accuracy of about 5° using regional and near-regional initial P-wave particle motions. Shear waves recorded downhole at the KNW-BH indicate that the strong alignment of initial S-wave particle motions previously observed at the (surface) KNW Anza site (KNW-AZ) is not generated in the near-surface weathered layer. The KNW-BH surface instrument, which sits atop a highly weathered zone, displays a significantly different (≈ 20°) initial S-wave polarization direction from that observed downhole and at KNW-AZ, which is bolted to an outcrop. Although downhole initial shear-wave particle motion directions are consistent with a shear-wave splitting hypothesis, observations of orthogonally polarized slow shear waves are generally elusive, even in seismograms recorded at 300 m. A cross-correlation measure of the apparent relative velocities of Sfast and Sslow horizontally polarized S waves suggests shallow shear-wave anisotropy, consistent with the observed initial S-wave particle motion direction, of 2.3 ± 1.7 per cent between 300 and 150 m and 7.5 ± 3.5 per cent between 150 and 0 m.

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Ward, RD, NG Elliott, and PM Grewe. "Allozyme and mitochondrial DNA separation of Pacific northern bluefin tuna, Thunnus thynnus orientalis (Temminck and Schlegel), from southern bluefin tuna, Thunnus maccoyii (Castelnau)." Marine and Freshwater Research 46, no. 6 (1995): 921. http://dx.doi.org/10.1071/mf9950921.

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Northern and southern bluefin tunas are morphologically similar and can be misidentified, posing problems for fishery management and marketing. Allozyme variation and restriction-site variation in mitochondrial DNA (mtDNA) were used to distinguish between the two species. A survey of 36 allozyme loci active in white muscle and liver tissue showed that the genetic identity between the species was high (Nei's I = 0.907). One diagnostic locus (sAH*) and two nearly diagnostic loci (ADA* and GDA*) were found, and four loci showed highly significant allele frequency differences (FH*, GPI-A*, PGDH* and sSOD*). A survey of the mtDNA genome, using 15 restriction enzymes and southern blotting, revealed five restriction enzymes that gave species-diagnostic restriction digest profiles (Ban I, Bcl I, Dra I, Pvu II, Xba I) and a further three enzymes (Pst I, Barn HI and Nco I) with large haplotype frequency differences. Mitochondrial DNA analysis provided more reliable discrimination of specimens than did allozyme analysis, although the more rapid allozyme identification will be accurate for most specimens. The two biochemical genetic methods were then used to identify Australian-caught fish of uncertain identity. Six of 12 tuna originally considered to be northern bluefin tuna were confirmed as northern bluefin and six were identified as southern bluefin. The presence of northern bluefin tuna as far south as south-western Tasmania was confirmed.

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Rouben, David. "P18. Minimally Invasive Transforaminal Posterior Interbody Fusion: A Prospective Study of 57 Consecutive Patients for a Minimum 5 Year Follow Up Treated for Symptomatic Segmental Lumbar Disc Disease-“SSLDD”." Spine Journal 9, no. 10 (October 2009): 122S—123S. http://dx.doi.org/10.1016/j.spinee.2009.08.276.

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Fan, Dongsheng, Loe Kie Soei, Rene Stubenitsky, Eric Boersma, Dirk J. Duncker, Pieter D. Verdouw, and Rob Krams. "Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 5 (November 1, 1997): H2146—H2154. http://dx.doi.org/10.1152/ajpheart.1997.273.5.h2146.

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In anesthetized pigs, we investigated whether asynchrony (Δ T) and nonuniformity (regional differences) in contractility (Δ E) could describe the interaction between normal and stunned myocardium. Mechanical interaction was evaluated by regional postsystolic work (PSW) before and after production of stunning by a 5-min occlusion of the left circumflex coronary artery [LCX (LCX stunning)] and a subsequent 10-min occlusion of the left anterior descending coronary artery [LAD (LAD stunning)]. Δ T and Δ E were intensified by intracoronary (LAD) infusions of dobutamine. From regional end-systolic pressure-segment length relationships, systolic segment shortening (SS), end-systolic elastance ( E), external work (EW), and PSW were determined. LCX stunning decreased SSLCX from 14 ± 2 (mean ± SE, n = 9) to 10 ± 2% and E LCX from 103 ± 25 to 52 ± 7 mmHg/mm, whereas the LAD region was unaffected. EWLCX decreased from 165 ± 16 to 138 ± 20 mmHg ⋅ mm, whereas PSWLCX increased from −4 ± 6 to 8 ± 3 mmHg ⋅ mm. Additional LAD stunning reduced SSLAD from 16 ± 2 to 9 ± 3% and E LAD from 79 ± 10 to 31 ± 6 mmHg/mm, without affecting SSLCX and E LCX. In the normal myocardium, PSWLADincreased and PSWLCX decreased, but, during local LAD dobutamine infusions after stunning, both PSWLCX and PSWLAD increased. In normal myocardium, the changes in PSWLCXcould be described by Δ T (65 ± 11%) and Δ E(37 ± 15%). After stunning of the LAD area, the contribution of Δ E increased to 55 ± 14% at the expense of Δ T (37 ± 15%). Similar contributions of Δ E (54 ± 13%) and Δ T (57 ± 13%) were found when both the LCX and LAD distribution areas were stunned. In normal myocardium, both Δ T and Δ E modulate mechanical interaction, with the contribution of Δ Texceeding that of Δ E. In stunned myocardium, both factors contribute, but the contribution shifts in favor of Δ E.

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Graf, J. D. "Genetic mapping in Xenopus laevis: eight linkage groups established." Genetics 123, no. 2 (October 1, 1989): 389–98. http://dx.doi.org/10.1093/genetics/123.2.389.

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Abstract Inheritance of alleles at 29 electrophoretically detected protein loci and one pigment locus (albinism) was analyzed in Xenopus laevis by backcrossing multiply heterozygous individuals generated by intersubspecies hybridization. Pairwise linkage tests revealed eight classical linkage groups. These groups have been provisionally numbered from 1 to 8 in an arbitrarily chosen order. Linkage group 1 includes ALB-2 (albumin), ADH-1 (alcohol dehydrogenase), NP (nucleoside phosphorylase), and ap (periodic albinism). Linkage group 2 contains ALB-1 and ADH-2, and probably is homeologous to group 1. Linkage group 3 comprises PEP-B (peptidase B), MPI-1 (mannosephosphate isomerase), SORD (sorbitol dehydrogenase), and mIDH-2 (mitochondrial isocitrate dehydrogenase). Linkage group 4 contains GPI-1 (glucosephosphate isomerase) and EST-4 (esterase 4). Linkage group 5 contains GPI-2 and PEP-D (peptidase D). Linkage group 6 comprises ACP-3 (acid phosphatase), sME (cytosolic malic enzyme), and GLO-2 (glyoxalase). Linkage group 7 consists of sSOD-1 (cytosolic superoxide dismutase), GPD-2 (glycerol-3-phosphate dehydrogenase), mME (mitochondrial malic enzyme), and the sex determining locus. Linkage group 8 includes FH (fumarate hydratase) and TRF (transferrin). Recombination frequencies between linked loci showed differences related to the genomic constitution (parental subspecies) and to the sex of the heterozygous parent. Independent assortment was observed between the duplicate ALB loci. This is true for the duplicate ADH, GLO, and MPI loci as well, supporting the view that these genes have been duplicated as part of a genome duplication that occurred in the evolutionary history of X. laevis. Comparative analysis of genetic maps reveals a possible conservation of several linkages from the Xenopus genome to the human genome.

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Bernardino, Melissa V., Craig H. Jones, William Levandowski, Ian Bastow, Thomas J. Owens, and Hersh Gilbert. "A multicomponent Isabella anomaly: Resolving the physical state of the Sierra Nevada upper mantle from Vp/Vs anisotropy tomography." Geosphere 15, no. 6 (November 8, 2019): 2018–42. http://dx.doi.org/10.1130/ges02093.1.

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Abstract The Isabella anomaly, a prominent upper-mantle high-speed P-wave anomaly located within the southern Great Valley and southwestern foothills of the Sierra Nevada, has been interpreted either as foundering sub-Sierran lithosphere or as remnant oceanic lithosphere. We used Vp/Vs anisotropy tomography to distinguish among the probable origins of the Isabella anomaly. S waveforms were rotated into the Sierran SKSFast and SKSSlow directions determined from SKS-splitting studies. Teleseismic P-, SFast-, SSlow-, SKSFast-, and SKSSlow-wave arrival times were then inverted to obtain three-dimensional (3-D) perturbations in Vp, Vp/VsMean, and percent azimuthal anisotropy using three surface wave 3-D starting models and one one-dimensional (1-D) model. We observed the highest Vp/Vs anomalies associated with slower velocities in regions marked by young volcanism, with the largest of these anomalies being the Mono anomaly under the Long Valley region, which extends to depths of at least 75 km. Peak Vp/Vs perturbations of +4% were found at 40 km depth. The low velocities and high Vp/Vs values of this anomaly could be related to partial melt. The high wave speeds of the Isabella anomaly coincide with low Vp/Vs values with peak perturbations of −2%, yet they do not covary spatially. The P-wave inversion imaged the Isabella anomaly as a unimodal eastward-plunging body. However, the volume of that Isabella anomaly contains three separate bodies as defined by varying Vp/Vs values. High speeds, regionally average Vp/Vs values (higher than the other two anomalies), and lower anisotropy characterize the core of the Isabella anomaly. The western and shallowest part has high wave speeds and lower Vp/Vs values than the surrounding mantle. The eastern and deepest part of the anomaly also contains high speeds and lower Vp/Vs values but exhibits higher anisotropy. We considered combinations of varying temperature, Mg content (melt depletion), or modal garnet to reproduce our observations. Our results suggest that the displaced garnet-rich mafic root of the Mesozoic Sierra Nevada batholith is found in the core of the Isabella anomaly. If remnant oceanic lithosphere exists within the Isabella anomaly, it most likely resides in the shallow, westernmost feature. Within the Sierra Nevada, the highest upper-mantle anisotropy is largely contained within the central portion of the range and the adjacent Great Valley. Anisotropy along the Sierra crest is shallow and confined to the lithosphere between 20 and 40 km depth. Directly below, there is a zone of low anisotropy (from 170 to 220 km depth), low velocities, and high Vp/Vs values. These features suggest the presence of vertically upwelling asthenosphere and consequent horizontal flow at shallower depths. High anisotropy beneath the adjacent western foothills and Great Valley is found at ∼120 km depth and could represent localized mantle deformation produced as asthenosphere filled in a slab gap.

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Jagjit, Sri Devi, Jordan Rupp, Robinson M. Ferre, Mary Kate Jordan, and Brian Bales. "Systematic Sonography Looking for Occult Wounds: accuracy of an abdominal ultrasound adjunct in penetrating trauma." Ultrasound Journal 12, no. 1 (November 26, 2020). http://dx.doi.org/10.1186/s13089-020-00194-3.

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Abstract Background Systematic Sonography Looking for Occult Wounds (SSLOW) in trauma is a novel technique for the evaluation of intra-abdominal wounds in penetrating trauma. No data exist regarding the effectiveness. The objective of this study was to evaluate the accuracy of the SSLOW exam. Methods This is a prospective collected case series conducted over a period of 10 months and took place at the Accident and Emergency Department (A&E) of the Georgetown Public Hospital Corporation (GPHC). The study enrolled patients presenting to the A&E who were 16 years old or greater with penetrating abdominal trauma. All patients with penetrating trauma received an E-FAST examination. If the E-FAST examination was negative, a SSLOW examination was completed. The sonographer evaluated for free fluid collection between the loops of bowel. The results of the SSLOW were compared to usual care (surgery consult, serial abdominal and E-FAST exams, laparotomy, and 7-day follow-up) and then categorized into four groups: true positive, false positive, true negative, and false negative. These results lead to four categorical values. From these results, sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratios were calculated. Results There were 5 (12%) true positives, 1 (2%) false positive, 37 (86%) true negatives, and zero (0%) false negative. The SSLOW was 100% sensitive (95% CI 5–100%) and 97% specificity (95% CI 74–96%). There was an 80% positive predictive value (95% CI 1.0–64% 95% CI) and 100% negative predictive value (95% CI 88–100%). The positive likelihood ratio was 8.4 (95% CI 3.69–19.1) and negative likelihood ratio was 0. Conclusion The SSLOW examination may be a useful tool in the evaluation of penetrating abdominal injuries.

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Thombs, Brett D., Kylene Aguila, Laura Dyas, Marie-Eve Carrier, Claire Fedoruk, Linda Horwood, Mara Cañedo-Ayala, et al. "Protocol for a partially nested randomized controlled trial to evaluate the effectiveness of the Scleroderma Patient-centered Intervention Network Support Group Leader EDucation (SPIN-SSLED) Program." Trials 20, no. 1 (December 2019). http://dx.doi.org/10.1186/s13063-019-3747-z.

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Abstract Background Some people with rare diseases rely on peer-led support groups for disease-specific education and emotional and practical support. Systemic sclerosis (SSc), or scleroderma, is a rare autoimmune connective tissue disease. Many people with SSc cannot access support groups, and, when support groups exist, they may not be sustained due to challenges that could be addressed via leader training. The Scleroderma Patient-centered Intervention Network (SPIN), along with SSc patient organization partners, developed a training program for SSc patient support group leaders, the Scleroderma Support group Leader EDucation (SPIN-SSLED) Program. We recently completed a feasibility trial in which we successfully delivered the program to two groups of support group leaders who reported a high level of satisfaction with the program and its delivery. The primary objective of the full-scale SPIN-SSLED trial is to evaluate the effect of the program on support group leaders’ self-efficacy for carrying out their leadership role. Secondary objectives include evaluating effects on leader burnout, leader satisfaction (participation efficacy), and emotional distress. Methods/design The SPIN-SSLED trial is a pragmatic randomized controlled trial (RCT) in which 180 support group leaders will be randomly allocated to training groups of 6 participants each or to a waitlist control. We will use a partially nested RCT design to reflect dependence between individuals in training groups, but not in the waitlist control. Participants allocated to the training program will receive the 13-module SPIN-SSLED Program, delivered via webinar over the course of 3 months in weekly 60–90-min sessions. The primary outcome is leader self-efficacy, measured by the Scleroderma Support Group Leader Self-efficacy Scale post-intervention. Secondary outcomes are leader self-efficacy at 3 months post-intervention, and leader burnout, volunteer job satisfaction (participation efficacy), and emotional distress post-intervention and at 3 months post-intervention. Discussion The SPIN-SSLED trial will test whether a training program for SSc patient support group leaders increases the self-efficacy of group leaders to carry out leadership tasks. The program has the potential to significantly improve the effectiveness and sustainability of existing SSc support groups, to increase the number of available support groups, and to be adapted for other chronic diseases. Trial registration ClinicalTrials.gov, NCT03965780. Registered on 29 May 2019.

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"The SPIN - Scleroderma Support Group Leader EDucation Program Trial (SPIN-SSLED)." Case Medical Research, May 29, 2019. http://dx.doi.org/10.31525/ct1-nct03965780.

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Radford, Julie, Judy Ireson, and Merle Mahon. "The organization of repair in SSLD classroom discourse: how to expose the trouble-source." Journal of Interactional Research in Communication Disorders 3, no. 2 (December 31, 2012). http://dx.doi.org/10.1558/jircd.v3i2.171.

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"Mast TLIF Lumbar Spinal Fusion Technique: A Twenty-Four Month Retrospective Analysis For The Treatment Of Symptomatic Segmental Lumbar Disc Disease - “SSLDD”." Internet Journal of Minimally Invasive Spinal Technology 1, no. 2 (2007). http://dx.doi.org/10.5580/e39.

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Li, Xiao-Qin, Chun Yin, Xiao-Li Li, Wen-Li Wu, and Kun Cui. "Comparison of the prognostic value of SYNTAX score and clinical SYNTAX score on outcomes of Chinese patients underwent percutaneous coronary intervention." BMC Cardiovascular Disorders 21, no. 1 (July 7, 2021). http://dx.doi.org/10.1186/s12872-021-02144-w.

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Abstract Background Previous studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone PCI; however, studies on comparison of these two scoring systems in Chinese population have been sparse. Methods To study the ability of SS and CSS in prediction of clinical outcomes of Chinese patients underwent percutaneous coronary intervention (PCI). We retrospectively calculated SS and CSS for 547 Chinese patients from a single center who underwent PCI. Patients were stratified into tertiles according to their SS and CSS. We compared the 2-year clinical outcomes in these patients stratified separately by SS and CSS tertiles. Results The incidence of major adverse cardiac and cerebro-vascular events (MACCE) was the highest in patients with SSHIGH (13.5%), comparing to 6.8% in SSMED and 0% in SSLOW (p < 0.0001). The Cox multivariable analysis showed that the SS and CSS were both strong independent predictors for MACCE [1.100 (1.069–1.133), 1.017 (1.010–1.025), both p < 0.0001]. The receiver operating characteristic (ROC) curves showed the areas-under-the-curves for all-cause death by CSS was slightly larger comparing to SS but not significantly (AUC SS, 0.64; AUC CSS, 0.71; p = 0.23). Conclusion We concluded that both the SS and CSS were capable of risk stratification of clinical outcomes in all-comers population as well as in low and moderate risk Chinese patients undergoing PCI with CSS showing slightly better advantage.

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Journal articles on the topic 'SSLOD'

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