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Journal articles on the topic 'Squamous cell carcinoma'

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Published: 4 June 2021
Last updated: 28 July 2024

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1

Hoy, Nathan, Joyce Wong, Muhammad Mahmood, and Alain Brassard. "Basaloid Squamous Cell Carcinoma of the Nasal Septum Presenting as a Primary Cutaneous Lesion." Journal of Cutaneous Medicine and Surgery 16, no. 5 (September 2012): 375–77. http://dx.doi.org/10.1177/120347541201600520.

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Background: Basaloid squamous cell carcinoma is a rare aggressive variant of squamous cell carcinoma, with a predilection for the head and neck region. There are only two case reports in the literature documenting a nasal cavity squamous cell carcinoma presenting as a primary cutaneous lesion. Objective: We report a rare case of nasal cavity basaloid squamous cell carcinoma presenting initially as a nasal bridge mass. Two initial biopsies revealed features consistent with basal cell carcinoma and basosquamous cell carcinoma, respectively. Result: Final surgical pathology showed extensive invasive squamous cell carcinoma with basaloid differentiation arising from the nasal septal mucosa with extension to the overlying skin. The clinicopathologic features were interpreted as basaloid squamous cell carcinoma. Conclusion: We discuss the difficulties in pathologic diagnosis of this condition given its varied phenotypical expression. As well, this case emphasizes the necessity for diagnostic vigilance when assessing a primary cutaneous lesion as it may be a rare presentation of an underlying malignancy extending to the skin. Contexte: Le carcinome squameux basaloïde est une variante rare et très maligne du carcinome squameux, qui touche le plus souvent la tête et le cou. La documentation médicale ne compte que deux exposés de cas sur le carcinome squameux de la cavité nasale se présentant sous forme de lésion cutanée primitive. Objectif: Nous faisons état ici d'un rare cas de carcinome squameux basaloïde de la cavité nasale, se présentant au départ comme une masse dans la voûte des fosses nasales. Deux biopsies ont été pratiquées au départ, et les résultats se sont montrés compatibles avec les caractéristiques du carcinome basocellulaire et du carcinome basospinocellulaire, respectivement. Résultat: L'examen histopathologique définitif de la pièce opératoire a révélé la présence d'un carcinome squameux invasif, étendu, accompagnée d'une différenciation basaloïde prenant naissance dans la muqueuse de la cloison nasale et se prolongeant jusqu'à la peau sus-jacente. Les manifestations clinicopathologiques laissaient croire à un carcinome squameux basaloïde. Conclusion: Il sera question ici des difficultés que pose le diagnostic histopathologique de cette affection compte tenu de son expression phénotypique variée. De plus, le cas met en évidence la nécessité de faire preuve de vigilance dans l'établissement du diagnostic lorsqu'on évalue des lésions cutanées primitives étant donné que celles-ci peuvent être une manifestation rare d'une tumeur maligne sous-jacente, qui s'étend jusqu'à la peau.
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2

Bajaj, Anubha. "Vortex and Crater-Squamous Cell Carcinoma Lung." Journal of Medical Case Studies 1, no. 1 (2023): 1–3. http://dx.doi.org/10.23880/jmcs-16000108.

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Squamous cell carcinoma lung manifests as a malignant tumefaction emerging from epithelial cells demonstrating squamous differentiation. Squamous epithelial differentiation within the neoplasm is represented by morphological features as variable proportion of intercellular bridges, focal intracellular or extracellular keratinization and configuration of keratin pearls, cogent immunohistochemistry may be advantageously applied for diagnostic confirmation. Squamous cell carcinoma lung may appear as keratinizing or non-keratinizing neoplasm. Additionally, diverse subtypes as solid, cystic, papillary, pseudo-glandular, alveolarfilling or sarcomatoid with spindle shaped cells may be observed.
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3

Diah Ari Bestari, Made, and R. Yully Prapyatiningsih. "Squamous Cell Carcinoma Sinonasal: A Case Report." International Journal of Science and Research (IJSR) 13, no. 6 (June 5, 2024): 797–801. http://dx.doi.org/10.21275/sr24608141101.

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4

Terry, Jefferson, Alessandro De Luca, Samuel Leung, Graeme Peacock, Yuzhuo Wang, W. Mark Elliot, and David Huntsman. "Immunohistochemical Expression of Neurotrophic Tyrosine Kinase Receptors 1 and 2 in Lung Carcinoma: Potential Discriminators Between Squamous and Nonsquamous Subtypes." Archives of Pathology & Laboratory Medicine 135, no. 4 (April 1, 2011): 433–39. http://dx.doi.org/10.5858/2010-0038-oa.1.

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Abstract Context.—The neurotrophic tyrosine kinase receptors NTRK1 and NTRK2 have been implicated in the pathogenesis of lung carcinomas. NTRK receptor expression has been reported in lung carcinomas; however, the clinical utility of immunohistochemical expression of these receptors is unclear. Objective.—To compare the immunohistochemical expression profiles of NTRK1 and NTRK2 in various histologic subtypes of lung carcinomas and correlate with patient outcome. Design.—Six hundred eighty-six unique lung cancer cases (including squamous cell carcinoma, adenocarcinoma, large cell carcinoma, small cell carcinoma, and carcinoid tumor) with clinical outcome data in tissue microarray format were immunohistochemically stained for NTRK1 and NTRK2 using commercially available antibodies, automated immunostaining, and standard protocols. Results.—Expression of both NTRK1 and NTRK2 correlates strongly with squamous histology. NTRK1 and NTRK2 are highly specific markers (1: 92.8%, 2: 96.4%) of squamous lung carcinoma when compared with the other carcinoma subtypes, including adenocarcinoma. Positive NTRK2 staining in squamous carcinoma correlates with improved disease-specific survival (P < .001) and overall survival (P = .047). Conclusions.—NTRK1 and NTRK2 are potentially useful immunohistochemical markers that may be particularly helpful in separating squamous cell carcinoma from adenocarcinoma.
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5

Chen, Hao, Liru Tian, Jiahong Chen, Peng Sun, Runkun Han, Xingping Wu, and Shuqin Dai. "Evaluation of 2 Commercially Systems for Detection of Serum Squamous Cell Carcinoma Antigen in Pan Squamous Cell Carcinoma." Cancer Control 27, no. 1 (January 1, 2020): 107327482098302. http://dx.doi.org/10.1177/1073274820983025.

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Background: This study compared the analytical performance of the Elecsys 602 (Roche Diagnostics) system with the I2000 (Abbott laboratories) system for the quantitative measurement of squamous cell carcinoma antigen (SCCA) to assess its role as an indicator in pan squamous cell carcinoma. Methods: 435 serum samples included pan squamous cell cancer group (n = 318) and healthy subjects (n = 52) and non-squamous cell group (n = 41) and benign diseases group (n = 24) were measured by 2 systems and compared. Results: The within-run precision coefficient of variation (CV) for Abbott and Roche systems were 3.34-4.88% and 0.95 -1.96%, and the total precision CV were 2.89-9.48% and 3.97-5.38%, respectively. Good correlation was showed in Abbott and Roche systems (slopes = 0.749, r = 0.9658). Serum SCCA in the groups of nasopharyngeal carcinomas, lung squamous cell carcinoma, esophageal squamous cell carcinoma, bladder cancer and cervical squamous cell carcinoma under the curve area (AUC) was more than 0.5, while the AUC in the non- nasopharyngeal carcinomas head and neck squamous cell carcinoma was less than 0.5. The AUC of 2 systems was statistically different in lung squamous cell carcinoma and nasopharyngeal carcinomas (P < 0.05). The levels of SCCA of 2 systems were similarities in esophageal squamous cell carcinoma(stage IV vs. stage 0a-II)and bladder cancer(stage I vs. stage Oa)and cervical squamous cell carcinoma(stage IIB-III vs. stage I-IIA), which advanced stage had higher level of SCCA than early stage. But the SCCA levels of 2 systems were inconsistent in bladder cancer (stage II-IV vs. stage Oa in Abbott), head and neck squamous cell carcinoma (stage IV vs. stage Oa-I in the Roche) and lung squamous cell carcinoma (stage III vs. stage I-II in the Roche). (P < 0.05) Conclusions: 2 systems correlated well in SCCA detection of squamous cell carcinoma, but there were individual differences. Serum SCCA may also contribute to the diagnosis of bladder cancer.
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6

Milroy, C. M., P. J. Robinson, and H. R. Grant. "Primary composite squamous cell carcinoma and large cell neuroendocrine carcinoma of the hypopharynx." Journal of Laryngology & Otology 103, no. 11 (November 1989): 1093–96. http://dx.doi.org/10.1017/s0022215100111107.

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AbstractNeuroendocrine carcinomas are rare neoplasms of the larynx and hypopharynx. Tumours composed of both neuroendocrine and Squamous cell elements are very rare. We report a case of a primary hypopharyngeal carcinoma composed of both squamous cell and large cell neuroendocrine carcinoma and discuss the treatment of this patient and management of neuroendocrine carcinomas of the larynx and hypopharynx.
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7

Gaddikeri1, Kavitha, and Deepak D. Bhorgonde2. "Assessment of role of mast cells in oral squamous cell carcinoma." Asian Pacific Journal of Health Sciences 3, Supplimentary 2016 (December 31, 2016): 63–66. http://dx.doi.org/10.21276/apjhs.2016.3.4s.9.

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8

Cuevas, Pedro, Sueiro A, Angulo J, Asin E, and Gim G. "Treatment of squamous lung cell carcinoma with inhaled etamsylate." International Journal of Medical Reviews and Case Reports 4, Reports in Clinical Medicine and (2020): 120. http://dx.doi.org/10.5455/ijmrcr.treatment-squamous-lung-cell-carcinoma.

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9

Ko, Christine J., G. Peter Sarantopoulos, Sunita Bhuta, and Scott W. Binder. "Scalp Paraffinoma Underlying Squamous Cell Carcinoma." Archives of Pathology & Laboratory Medicine 128, no. 10 (October 1, 2004): 1171–72. http://dx.doi.org/10.5858/2004-128-1171-spuscc.

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Abstract We report the case of an 84-year-old man with multiple squamous cell carcinomas located on his bald scalp, arising in association with underlying paraffinoma. Histologically, poorly differentiated, acantholytic squamous cell carcinomas were located above characteristic pseudocystic spaces. Carcinomas have been reported in association with penile and breast paraffinomas, but we are unaware of any reports of squamous cell carcinoma arising over a scalp paraffinoma.
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10

Shah, Akeesha A., Susanne K. Jeffus, and Edward B. Stelow. "Squamous Cell Carcinoma Variants of the Upper Aerodigestive Tract: A Comprehensive Review With a Focus on Genetic Alterations." Archives of Pathology & Laboratory Medicine 138, no. 6 (June 1, 2014): 731–44. http://dx.doi.org/10.5858/arpa.2013-0070-ra.

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Context.— Squamous cell carcinoma of the upper aerodigestive tract is a heterogenous entity. Although conventional squamous cell carcinomas are easily recognized, the morphologic variants of squamous cell carcinoma can present a diagnostic challenge. Familiarity with these variants is necessary because many are associated with unique risk factors and are characterized by specific molecular alterations (eg, nuclear protein in testis midline carcinomas). Perhaps the most important distinction is in identifying viral-related from nonviral-related carcinomas. The accurate diagnosis of these variants is necessary for prognostic and therapeutic reasons. Objectives.— To provide a clinicopathologic overview and summary of the molecular alterations of the common squamous cell carcinoma variants, including verrucous, spindle cell, acantholytic, adenosquamous, basaloid, and papillary squamous cell carcinoma, as well as nuclear protein in testis midline carcinoma, and to discuss the distinguishing features of human papillomavirus- and Epstein-Barr virus-related squamous cell carcinomas. Data Sources.— Published peer-reviewed literature. Conclusions.— Familiarity with squamous cell carcinoma variants is essential for proper diagnosis and to guide appropriate clinical management. Further insight into the molecular alterations underlying those variants may lead to alterations in existing treatment approaches and to evolution of novel treatment modalities.
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11

Lam, King Y., and Kwok W. Chan. "Molecular Pathology and Clinicopathologic Features of Penile Tumors." Archives of Pathology & Laboratory Medicine 123, no. 10 (October 1, 1999): 895–904. http://dx.doi.org/10.5858/1999-123-0895-mpacfo.

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AbstractObjectives.—To examine the histologic features of p21 in penile tumors and to determine the role of p21 and p53 in the pathogenesis of this group of tumors.Methods.—The clinicopathologic features of 87 patients with penile tumors were studied. The expression of p53 and p21 proteins in 49 cases was investigated by immunohistochemistry.Results.—Of the 87 tumors studied, 84 represented primary penile tumors (72 malignant and 12 benign) and 3 represented secondary tumors (2 from bladder, 1 from nasopharynx). The primary malignant penile tumors included 66 surface carcinomas with squamous differentiation (92%), 3 cases of Paget disease (4%), 1 case of Bowen disease (1%), and 2 penile urethral squamous cell carcinomas (3%). The former group was subdivided into squamous cell carcinoma (n = 50), verrucous carcinoma (n = 8), basaloid squamous cell carcinoma (n = 3), adenoid squamous cell carcinoma (n = 3), spindle cell carcinoma (n = 1), and adenosquamous carcinoma (n = 1). The benign tumors were squamous cell papillomas (n = 10) and fibromatoses (n = 2). Expression of p21 and p53 was noted in 40% and 89%, respectively, of the 47 patients with primary surface penile carcinoma with squamous differentiation. Positive p21 and p53 expression was also seen in 2 cases of Paget disease. Staining for p21 was often weak and was found in the suprabasal region of carcinomas with squamous differentiation, while p53 expression was seen in the basal region of squamous cell carcinomas. Preinvasive lesions also showed p21 and p53 expression. An inverse correlation between p53 and p21 expression (p53+/p21− or p53−/p21+) was noted in half of the squamous cell carcinomas, 4 of 5 verrucous carcinomas, 2 of 3 basaloid squamous cell carcinomas, and in 1 spindle cell carcinoma. The other cases did not show this correlation.Conclusions.—Penile tumors had different histologic variants and p21/p53 expression patterns. Expression of p21 did play a role in some tumors and could be dependent or independent of p53 expression.
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12

Vani D, Vani D., Sheelashree A. N. Sheelashree A. N, Apoorva N. Apoorva N, and Bharathi M. Bharathi M. "Squamous Cell Carcinoma: A Stranger in The Breast." Annals of Pathology and Laboratory Medicine 7, no. 4 (April 29, 2020): C45–47. http://dx.doi.org/10.21276/apalm.2666.

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13

Dr. Shool Rohit S, Dr Shool Rohit S., Dr Anand P. Zingade, and Dr Manish Kumar. "Management of Neck in Oral Squamous Cell Carcinoma." Indian Journal of Applied Research 3, no. 6 (October 1, 2011): 419–22. http://dx.doi.org/10.15373/2249555x/june2013/140.

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14

Leão, Philipe, Letícia Oliveira, Willian Santos, Matheus Moreira, and Roselene Ecco. "Esophageal squamous cell carcinoma in a backyard rooster." Brazilian Journal of Veterinary Pathology 12, no. 1 (March 30, 2019): 15–18. http://dx.doi.org/10.24070/bjvp.1983-0246.v12i1p15-18.

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15

Drazek, M., M. Lew, S. Lew, J. Szarek, I. Balicki, and L. Della Salda. "Equine ocular squamous cell carcinoma: a case report." Veterinární Medicína 60, No. 7 (July 15, 2016): 379–86. http://dx.doi.org/10.17221/8386-vetmed.

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16

L Chudasama Dharmesh, Shilpa. "A Rare Case Report: Renal Squamous Cell Carcinoma." International Journal of Science and Research (IJSR) 12, no. 6 (June 5, 2023): 1157–58. http://dx.doi.org/10.21275/sr23604182339.

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17

Ferlito, Alfio, Kenneth O. Devaney, and Alessandra Rinaldo. "Clinicopathological Consultation Squamous Neoplastic Component in Unconventional Squamous Cell Carcinomas of the Larynx." Annals of Otology, Rhinology & Laryngology 105, no. 11 (November 1996): 926–32. http://dx.doi.org/10.1177/000348949610501115.

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Both otolaryngologists and surgical pathologists arc involved in the diagnosis and treatment of lesions of the larynx that are best diagnosed as invasive squamous cell carcinomas of some specified degree of differentiation, not further subclassified (that is, conventional squamous cell carcinomas). On occasion, however, a patient will present with an invasive tumor that on histologic examination diverges from the expected pattern of a squamous cell carcinoma of the usual type and so raises the question of proper classification (on the part of the pathologist) and, following classification, a consideration of the prognostic and therapeutic implications of such a classification (on the part of the clinician). While some of these unconventional squamous cell carcinomas are rather indolent lesions (as, for example, the hybrid verrucous squamous cell carcinoma), others behave in a fashion similar to conventional squamous cell carcinomas (such as the adenoid squamous cell carcinomas), and yet others seem to behave more aggressively than do conventional squamous cell carcinomas of a similar size and stage (examples include the basaloid squamous cell carcinomas and adenosquamous carcinomas). Finally, the possibility exists within the larynx, as elsewhere in the body, that a nonepithelial lesion such as malignant melanoma may mimic a tumor more commonly encountered in that vicinity — namely, a squamous cell carcinoma — and so receive inappropriate treatment if such mimicry is not recognized.
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18

Ahmed Elkammar, Hala. "Effect of human bone marrow derived mesenchymal stem cells on squamous cell carcinoma cell line." International Journal of Academic Research 6, no. 1 (January 30, 2014): 110–16. http://dx.doi.org/10.7813/2075-4124.2014/6-1/a.14.

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19

Adams, M., and R. Caffrey. "Triple primary cancers of the head and neck: case report and literature review." Journal of Laryngology & Otology 128, no. 6 (May 22, 2014): 552–54. http://dx.doi.org/10.1017/s0022215114000905.

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AbstractBackground:Coincident thyroid and head and neck squamous cell carcinomas are rare. This paper presents a case of synchronous laryngeal squamous cell carcinoma, follicular thyroid carcinoma and micropapillary thyroid carcinoma.Methods:A PubMed search was performed for articles describing synchronous thyroid and head and neck squamous cell carcinomas, using the search terms ‘thyroid cancer’, ‘cancer of the head and neck’, ‘synchronous’ and ‘synchronous neoplasm’.Results:The literature suggests that the head and neck squamous cell carcinoma stage is a better predictor of outcome than the extent of surgical treatment of the thyroid gland in synchronous malignancies.Conclusion:The decision regarding surgical treatment of the thyroid in synchronous thyroid and head and neck squamous cell carcinomas should take several factors into account. The head and neck squamous cell carcinoma stage is the strongest predictor of outcome, although patient-related factors and the location of malignant thyroid tissue may also affect management.
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20

Skelton, Henry G., Steven Flax, Lawrence Chang, and Kathleen J. Smith. "Squamous Cell Carcinomas Arising From Adnexal Ductal Cysts." Archives of Pathology & Laboratory Medicine 126, no. 1 (January 1, 2002): 76–78. http://dx.doi.org/10.5858/2002-126-0076-sccafa.

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Abstract Malignant tumors arising from adnexal cysts are rare. We report 2 cases of squamous cell carcinomas that developed within cystic structures arising from adnexal ducts. An in situ hybridization technique for human papillomaviruses (HPV)-6/11, -16, -18, and -31, and immunohistochemical staining for p53 were performed. Both tumors showed focal expression of HPV-16 within areas showing squamoid changes and diffuse expression of p53 within the areas of invasive squamous cell carcinoma. Although nuclear staining for HPV has been identified in tumors of adnexal origin, to our knowledge these are the first cases in which a highly oncogenic HPV subtype, HPV-16, has been identified within squamous cell carcinomas arising from adnexal ductal structures. These cases may help explain primary cutaneous squamous cell carcinomas with no epidermal origin.
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21

Rosen, Jordan, Katherine Nolan, Noah Shaikh, Les Rosen, and Martin Zaiac. "Coexisting Basal Cell Carcinoma and Squamous Cell Carcinoma in Congenital Nevus Sebaceous." SKIN The Journal of Cutaneous Medicine 2, no. 3 (April 30, 2018): 181–85. http://dx.doi.org/10.25251/skin.2.3.6.

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Nevus sebaceous is a congenital epidermal hamartoma characterized by hyperplastic changes to the epidermis and adnexa. Nevus sebaceous is associated with an elevated risk of cutaneous neoplasms, most often benign; however, malignant neoplasms, most notably basal cell carcinoma, can also present in these patients. Although a rare occurrence, more often affecting adult patients, squamous cell carcinomas have also been reported to arise at the site of pre-existing nevus sebaceous. Herein we report a unique case of a patient with basal cell carcinoma and squamous cell carcinoma arising concurrently in the same nevus sebaceous.
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22

KALDRYMIDOU (Ε. ΚΑΛΔΡΥΜΙΔΟΥ), E., G. KANAKOUDIS (Γ. ΚΑΝΑΚΟΥΔΗΣ), Th TOLIOU (Θ. ΤΟΛΙΟΥ), Th POUTAHIDIS (Θ. ΠΟΥΤΑΧΙΔΗΣ), and M. KARAGIANNOPOULOU (Μ. ΚΑΡΑΓΙΑΝΝΟΠΟΥΛΟΥ). "Squamous cell carcinoma of the dog." Journal of the Hellenic Veterinary Medical Society 50, no. 3 (January 31, 2018): 250. http://dx.doi.org/10.12681/jhvms.15718.

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Squamous cell carcinoma is the most common skin neoplasm with cellular evidence of malignancy. Neoplastic cells preserve characteristics of the stratum spinosum and infiltrate dermis. Squamous cell carcinomas classification is based on the degree of cell differentiation and tumor architecture and includes more than one categories. Immunohistochemistry is often applied in order to distinguish this carcinoma from other epithelial neoplasms. In the present study four squamous cell carcinomas of the dog were examined and classified. Three of them (2,3,4) presented low rates of differentiation so, immuhistochemical detection of cellular keratin was performed, in order to avoid confusion with other keratinizing epithelial neoplasms. Two out of the three above mentioned tumors (3,4) exhibited acantholysis and pseudogranular structures. Immunohistochemical detection of the carcinoembryonic antigen provided evidence to distinguish them from adenocarcinomas. Finally, in the fourth tumor (4) areas of diffuse cellular proliferation, without obvious keratinization, were observed. Many of these cells appeared elongated. In this case, the immunohistochemical detection of vimentin was performed in order to find out if these cells belonged to the connective tissue or to a spindle-cell squamous cell carcinoma.
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23

Varghese, Alina Mariam, and Sankar, S. "Follicular Carcinoma Thyroid with Focus of Squamous Cell Carcinoma - A Case Report." Saudi Journal of Pathology and Microbiology 8, no. 03 (March 4, 2023): 46–49. http://dx.doi.org/10.36348/sjpm.2023.v08i03.001.

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Collision tumors of the thyroid gland are a rare entity. Primary squamous cell carcinoma of the thyroid (PSCCT) is a malignant epithelial tumor, composed entirely of cells with squamous differentiation and accounting for less than 1% of all malignancies of the thyroid gland. PSCCT arises from other thyroid diseases such as Hashimoto’s thyroiditis, tall cell variant papillary carcinoma, follicular carcinoma, and anaplastic carcinoma1. We describe a patient with the combination of a well-differentiated squamous cell carcinoma and follicular carcinoma of the thyroid.
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24

Ateş, İhsan, Ozan Yazıcı, Hale Ateş, Doğan Yazılıtaş, Ayşe Naz Özcan, Yetkin Ağaçkıran, and Nurullah Zengin. "Squamous Cell Cancer of The Lung with Synchronous Renal Cell Carcinoma." Turkish Thoracic Journal 17, no. 3 (September 10, 2016): 125–27. http://dx.doi.org/10.5578/ttj.30510.

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25

E. Ghazy, Shaimaa, Ehab S. Abdel-Hamid, Amira M. Ali, Aly F. Mohamed, and Houry M. Baghdadi. "Paclitaxel effect on head and neck squamous cell carcinoma cell line." International Journal of Academic Research 6, no. 1 (January 30, 2014): 94–99. http://dx.doi.org/10.7813/2075-4124.2014/6-1/a.12.

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26

Krunic, AL, DR Garrod, NP Smith, GS Orchard, and OB Cvijetic. "Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis." Acta Dermato-Venereologica 76, no. 5 (September 1, 1996): 394–98. http://dx.doi.org/10.2340/0001555576394398.

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The distinction between keratoacanthoma and squamous cell carcinoma is a common dermatopathological dilemma. Although the mainstay of the diagnosis is still clinico-pathological correlation, many dermatopathologists now include keratoacanthomas in the spectrum of squamous cell carcinomas. Recent reports, however, have pointed out that keratoacanthoma is "deficient squamous cell carcinoma" since it loses the expression of bcl-2 antigen, consistent with initiation of apoptosis, i.e. its involution. Electron microscope studies performed in keratoacanthomas and squamous cell carcinomas also revealed significantly reduced desmosomes in squamous cell carcinoma, but not in keratoacanthoma. A series of 38 keratoacanthomas and 62 squamous cell carcinomas of the skin (28 well-differentiated, 21 moderately differentiated and 13 poorly differentiated) were stained immunohistochemically with the monoclonal antibody 32-2B to desmosomal glycoproteins desmoglein 1 and desmoglein 3. Thirty-five keratoacanthomas showed extensive pericellular desmoglein expression. Three keratoacanthomas and 20 squamous cell carcinomas (19 well-differentiated, 1 moderately differentiated) showed focal staining, and in 11 squamous cell carcinomas (2 moderately differentiated, 9 poorly differentiated) the staining was negative. The remaining 31 squamous cell carcinomas (9 well differentiated, 18 moderately differentiated, 4 poorly differentiated) showed juxtanuclear staining. None of the squamous cell carcinomas exhibited the extensive pericellular pattern found in keratoacanthomas. Assessment of staining intensity, by 3 independent examiners, revealed a strong negative correlation between desmoglein expression and degree of dysplasia in the squamous cell carcinomas (p < 0.01). This antibody therefore clearly distinguishes these tumours and may be of value in the differential diagnosis of keratoacanthoma and squamous cell carcinomas in routine histopathology.
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27

Chehbouni, Mohamed, and Othmane Benhoummad. "Synchronous Association of Squamous Cell Carcinoma of the Larynx and Clear Cell Renal Cell Carcinoma: A Case Report." European Journal of Medical and Health Sciences 3, no. 3 (June 23, 2021): 64–66. http://dx.doi.org/10.24018/ejmed.2021.3.3.903.

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Laryngeal squamous cell carcinomas represent the most frequent form (over 90%) of laryngeal cancer, but their association with renal tumors is rare; the literature most often reports the synchronous association of carcinoma of the larynx with carcinoma of the upper aerodigestive tract or with bronchial carcinoma. We report the case of a 60-year-old patient, who is followed for a clear cell carcinoma of the kidney, and in whom we made the diagnosis of a squamous cell carcinoma of the larynx. We illustrate through this observation the rarity and the epidemiological profile of this presentation with a broad review of the literature.
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28

Mark, Brady, Jaxon Dawson, and Dominic Chase. "The Management of Actinic Keratosis and Squamous Cell Carcinoma." Dermatology and Dermatitis 2, no. 1 (February 26, 2018): 01–03. http://dx.doi.org/10.31579/2578-8949/019.

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Background: Actinic keratosis or solar keratosis is a common skin lesion caused by sun damage that progresses to squamous cell carcinoma. It has been suggested that actinic keratosis is in fact SCC in situ. Objective: This literature review was conducted to investigate the differences between actinic keratosis and squamous cell carcinoma and whether actinic keratosis should in fact be managed as squamous cell carcinoma. Methods: A literature review was conducted to assess the differences between actinic keratosis and squamous cell carcinoma. We conducted searches of Pubmed, Cochrane and Medline for articles published between January 1, 2000 and April 30, 2014, using the following search terms: actinic keratosis, solar keratosis, skin cancer, squamous cell carcinoma, dermoscopy, sun exposure, ultra violet radiation, and dysplasia. Studies published in English were selected for inclusion in this review as were additional articles identified from bibliographies. Results: It is difficult to distinguish between both actinic keratosis and squamous cell carcinoma. Perhaps a classification system for actinic keratosis including early in situ SCC type AK1, early in situ SCC type AK2 and in situ SCC type actinic keratosis is needed. Conclusion: Actinic keratosis invades the basement membrane and as such may progress into invasive SCC. Superficially actinic keratoses are not distinguishable from a superficial SCC and as such may go unrecognized or inaccurately diagnosed.
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29

Yousaf, Sabeeh, Sajjad Ali Shahid, and Obaid Hayat. "SQUAMOUS CELL CARCINOMA." Professional Medical Journal 25, no. 12 (December 8, 2018): 1840–47. http://dx.doi.org/10.29309/tpmj/18.4785.

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Background: Head and Neck Squamous cell carcinoma is the sixth most common cancer globally with increasing frequency in developing countries. Despite huge advancement in surgery, radiotherapy and chemotherapy there is a little changed in the overall survival rate for patient with HNSCC over the past few decades. Due to its late diagnosis and lack of availability of reliable biomarker for this disease, its incidence is still on rise. Aims &Objectives: This study was aimed to study the expression of miR-21 in the tumor genesis of HNSCC. The objective of the study is to analyze the expression profile of miR-21 in HNSCC, to study the miRNA expression profile of miR-21 between control and tumor samples, to study the expression profile of miR-21 benign tumors and different categories of HNSCC Tumors on the basis of Histological Differentiation, gender-based Comparison of Benign and Malignant HNSCC Tumors, age-based Comparison of Benign and Malignant HNSCC Tumors, tumor Sitebased Comparison of Benign and Malignant HNSCC Tumors. Study Design: Case-control study. Study Setting: The University of Lahore. Period: June -2014 June -2105. Materials & Methods: In this research, 43 Formalin-fixed paraffin embedded (FFPE) tissue samples (31 malignant HNSCC samples and 12 benign tumors from the same region) of both genders and aged 15-80 years were included in this study. 31 cases were malignant tumors were further consisted of 14 well-, 11 moderately- and 6 poorly differentiated tumors. Total RNA was extracted using PureLink FFPE RNA Isolation Kit and Two-Step RT-PCR was performed. TaqMan primer/ probe sets were used for the target miRNA- 221, while RNUB6 was the normalization control.By calculating __Ct and fold change difference according to Livak method. late onset disease the Relative quantification was done to determine the level of expression of miRNA-221. Tumor site did not show any effect on miR-21 expression levels. Results: Our results showed that the malignant samples have higher expression level of miR-21 then benign control samples. Significantly higher expression was observed in moderately and poorly categories of HNSCC. Gender-based expression showed that females had higher level of expression, while it was found that its expression is high in late onset disease. Tumor site did not show any effect on miR-21 expression levels. Conclusion: Our miRNA expression profile provides a potential strategy for finding new head and neck squamous cell carcinoma (HNSCC) molecular targets. miR-21 could be regarded as potential diagnostic marker in HNSCC.
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30

Williams, Ali. "Squamous cell carcinoma." Veterinary Nursing Journal 21, no. 3 (March 2006): 14–17. http://dx.doi.org/10.1080/17415349.2006.11013455.

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31

Shulstad, Raymond M., and Steven Proper. "Squamous Cell Carcinoma." Journal of the Dermatology Nurses' Association 2, no. 1 (January 2010): 12–16. http://dx.doi.org/10.1097/jdn.0b013e3181cb5165.

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&NA;. "Squamous Cell Carcinoma." Journal of the Dermatology Nurses' Association 2, no. 1 (January 2010): 17–18. http://dx.doi.org/10.1097/jdn.0b013e3181cecc51.

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33

Hawrot, Aimee, Murad Alam, and Désirée Ratner. "Squamous cell carcinoma." Current Problems in Dermatology 15, no. 3 (May 2003): 91–133. http://dx.doi.org/10.1016/s1040-0486(03)00005-x.

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34

Marks, R. "Squamous cell carcinoma." Lancet 347, no. 9003 (March 1996): 735–38. http://dx.doi.org/10.1016/s0140-6736(96)90081-1.

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35

Keilin, Steve, Melchor Demetria, Bashar M. Attar, and Amila Orucevic. "Squamous Cell Carcinoma." American Journal of Gastroenterology 100 (September 2005): S228. http://dx.doi.org/10.14309/00000434-200509001-00603.

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36

Cook, Chris, and Roland Watura. "Squamous cell carcinoma." Hospital Medicine 60, no. 12 (December 1999): 910–11. http://dx.doi.org/10.12968/hosp.1999.60.12.1260.

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37

Davis, Jeremy, and Jeremy Bordeaux. "Squamous Cell Carcinoma." JAMA Dermatology 149, no. 12 (December 1, 2013): 1448. http://dx.doi.org/10.1001/jamadermatol.2013.6947.

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38

Chuang, Tsu-Yi. "Squamous Cell Carcinoma." Archives of Dermatology 126, no. 2 (February 1, 1990): 185. http://dx.doi.org/10.1001/archderm.1990.01670260055010.

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39

Lam, Alfred King-yin. "Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification." Endocrine-Related Cancer 27, no. 6 (June 2020): R177—R192. http://dx.doi.org/10.1530/erc-20-0045.

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The aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of the World Health Organization classification of endocrine tumours. The carcinomas occur in 83 women and 34 men (female to male ratio is 2.4 to 1) and with median age at presentation of 64. Half of these squamous cell carcinomas of thyroid were moderately differentiated. PAX-8 protein is a sensitive marker for confirming the thyroid origin of the carcinoma. The carcinoma is also positive for p63, p40, cytokeratins 5/6, 7,19 and negative for cytokeratins 20 and 10/13. P53 overexpression is common. The most important differential diagnosis is direct infiltration or metastatic involvement by squamous cell carcinoma from other organs. Limited mutation analysis revealed BRAF mutation in some squamous cell carcinomas of the thyroid. The genetic profile appears to be different from anaplastic thyroid carcinomas. Primary squamous cell carcinoma of thyroid had lymph node involvement in 59% and distant metastases in 26%. The median survival of the patients was 8 months. Curative surgery offers the best survival for the patients with the carcinoma. To conclude, primary squamous cell carcinoma of the thyroid gland has distinctive clinical, pathological and molecular profiles. It is important to recognize this unique variant of thyroid carcinoma for possible curative surgical resection and to do more genomic works on the entity to uncover the molecular pathogenesis.
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40

Chang, Christopher Y., William E. Chapman, and Julia A. Furdyna. "Differentiating between Squamous Cell Carcinoma and Pigmented Squamous Cell Carcinoma." Ear, Nose & Throat Journal 84, no. 12 (December 2005): 766–67. http://dx.doi.org/10.1177/014556130508401210.

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41

Kaur, Kushaldeep, Amrinder Kaur, Harpal Singh, Shivam Sethi, and Harleen Kaur. "Pigmented Squamous Cell Carcinoma of Skin: A Rare Entity." Scholars Journal of Medical Case Reports 12, no. 01 (January 30, 2024): 119–22. http://dx.doi.org/10.36347/sjmcr.2024.v12i01.031.

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Squamous cell carcinoma, the second most common form of skin cancer, is caused by the cumulative exposure of skin to UV light. It originates from epidermal keratinocytes or adnexal structures (such as eccrine glands or pilosebaceous units). Squamous cell carcinoma (SCC) has several histologic variants, such as clear cell SCC, signet ring SCC, basaloid SCC, desmoplastic SCC, verrucous and pigmented SCC, among others. Although dendritic melanin containing melanocytes can be seen in a variety of epithelial neoplasms, but only 0.01% to 7% of all squamous cell carcinomas (SCC) are pigmented. Most of which have occurred in the oral and ocular mucosa, with relatively few cases to originate in the skin. The main clinical differential diagnosis for pigmented squamous cell carcinoma are pigmented basal cell carcinoma and melanoma. Herein we report a case of 62 year old male who presented with a blue-black growth over the left inguinal region. Routine lab investigations showed no change and no lymphadenopathy was observed. Biopsy of the growth was received and histopathological evaluation revealed pigmented squamous cell carcinoma. Microscopic examination revealed squamous cell carcinoma with numerous dendritic melanophages showing pigmented melanin. Pigmented SCC can be confused with benign and malignant melanocytic neoplasms, pigmented basal cell carcinoma, actinic keratosis, seborrheic keratosis and pigmented bowen’s disease. In conclusion, this case demonstrates that although pigmented squamous cell carcinomas are relatively rare, they should be included in differential diagnosis of pigmented cutaneous lesions and must be distinguished from other tumors with similar histological findings.
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Battal, Muharrem, Ozgur Bostancı, Tulay Basak, Kinyas Kartal, and Feza Ekiz. "Pure Squamous Cell Carcinoma of the Duodenum." Case Reports in Surgery 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/714640.

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Primary carcinomas of the small intestine are extremely rare neoplasms. Most of these are adenocarcinomas. Primary squamous cell carcinoma (SCC) of small intestine is exceptionally rare with only occasional case reports in the literature. We report here a surgically treated patient with squamous cell carcinoma arising from duodenal diverticula in the third part of the duodenum.
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43

Syed, Sofia Ali, Mulazim Hussain Bukhari, Riaz Ahmed Warraich, Fauzia Quadir, Asifa Iqbal, and Faryal Ali Syed. "ORAL SQUAMOUS CELL CARCINOMA." Professional Medical Journal 22, no. 01 (January 10, 2015): 018–26. http://dx.doi.org/10.29309/tpmj/2015.22.01.1406.

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Background: The aim of this study was to evaluate clinico-pathologicalparameters and the status of argyrophilic nucleolar organizer regions stain in various histologicalgrades of oral squamous cell carcinoma. Materials and Methods: A cross sectional studywas conducted on fifty cases of oral squamous cell carcinoma. The specimen were collectedfrom the department of Oral & Maxillofacial Surgery and processed for hematoxylin and eosinstain and AgNOR stain Pathology Laboratory, King Edward Medical University Lahore. Results:Bidi smoking is associated with oral squamous cell carcinoma. The AgNOR (mAgNOR andpAgNOR) status was significantly low in well differentiated and moderately differentiatedcompared to poorly differentiated oral squamous cell carcinoma (p =0.001). AgNOR size inpoorly differentiated was significantly higher than the AgNOR size in well differentiated oralsquamous cell carcinoma. Similarly the distribution of AgNOR in moderately and poorlydifferentiated oral squamous cell carcinoma was significantly high. The AgNORs index wassignificantly high in poorly differentiated squamous cell carcinoma as compared to welldifferentiated and moderately differentiated squamous cell carcinoma. Conclusions: The useof AgNORs stain is easy, valid and reliable method to assess the histological grading of oralsquamous cell carcinoma and should be used to predict the prognosis of patients.
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Proia, Alan D., M. Angelica Selim, Jason C. Reutter, and John J. Michon. "Basal Cell–Signet-Ring Squamous Cell Carcinoma of the Eyelid." Archives of Pathology & Laboratory Medicine 130, no. 3 (March 1, 2006): 393–96. http://dx.doi.org/10.5858/2006-130-393-bcscco.

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Abstract A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fleshy, fungating growth involving more than 60% of the right lower eyelid. Excisional biopsy disclosed a neoplasm arising from the epidermis composed of adjoining basal cell and signet-ring squamous cell carcinoma, without a transition zone. The cells comprising the basal and squamous cell carcinomas were distinct immunophenotypically, with only the basal cell carcinoma reacting with Ber-EP4 and CAM 5.2 antibodies. To our knowledge, this case represents the first example of a collision tumor composed of basal cell and signet-ring squamous cell carcinoma.
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Pimenta, Jos, Justina Prada, Isabel Pires, and M. Cotovio. "Programmed-cell death ligand 1 (PD-L1) expression in equine sarcoids and squamous cell carcinoma." Open Veterinary Journal 14, no. 6 (2024): 1476. http://dx.doi.org/10.5455/ovj.2024.v14.i6.16.

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Background: Sarcoids and squamous cell carcinomas (SCC) are the most concerning equine oncological diseases. Both tumors are challenging to manage due to their invasive behavior and high prevalence of recurrences. Furthermore, squamous cell carcinomas have propensity to metastasize. Programed cell-death ligand 1 (PD-L1) has been one of the main therapeutic targets for immunotherapy in various human tumors. PD-L1 research is equine tumors is scarce and more efforts are necessary to understand the potential of this biomarker as therapeutical target. Aim: Evaluate the immunohistochemical expression of PD-L1 in equine sarcoids and squamous cell carcinoma. Methods: Thirteen equine tumors (seven sarcoids and 6 squamous cell carcinomas) were tested by immunohistochemistry and evaluated semi quantitatively to assess the percentage of positive cells. Results: None of the sarcoids presented PD-L1 expression. Regarding squamous cell carcinoma, 2 tumors presented <10% of labeled cells; 2 tumors presented 10-25% of labeled cells and 2 tumors presented 25-50% of labeled cells. There were statistically significant differences between sarcoids and squamous cell carcinoma regarding the expression of PD-L1. Conclusion: Our results point to the fact that PD-L1 could be a potential therapeutic target against SCC, and also encourage in-depth studies in this area, with larger sample sizes.
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46

Maganito, Sandy, and Jose Carnate. "Acantholytic Squamous Cell Carcinoma." Philippine Journal of Otolaryngology Head and Neck Surgery 36, no. 2 (November 11, 2021): 57. http://dx.doi.org/10.32412/pjohns.v36i2.1823.

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A 63-year-old Filipino man presented with a one-month history of painful ulceration on the alveolar socket of a molar tooth of the right hemimandible. The patient consulted at a tertiary hospital, where he underwent incisional biopsy. Microscopically, the biopsy specimen showed neoplastic cells arranged in a pseudoglandular alveolar pattern with cystic spaces lined with atypical polygonal cells. (Figure 1) Detached “glassy” keratinocytes which are dyskeratotic acantholytic cells were seen within these cystic spaces. (Figure 2) Areas with features of more conventional squamous cell carcinoma, i.e., intercellular bridges and abundant eosinophilic cytoplasm, were also present. (Figure 3) Immunohistochemical staining for p40 showed diffuse nuclear positivity. (Figure 4) Given these findings, a diagnosis of acantholytic squamous cell carcinoma (ASCC) was made.1 Acantholytic squamous cell carcinoma (historically known as adenomatoid squamous cell carcinoma or adenoacanthoma) is a histologic variant of squamous cell carcinoma (SCC) that most often presents as an ulcer on sun-exposed areas, mostly in elderly males.1,2 ASCCs of the oral cavity are rare, with fewer than 60 cases reported in the literature.3 In a series of 55 cases describing intraoral ASCCs, the most common sites of ASCC were the tongue (24/55) and the maxilla/maxillary gingiva and/or palate (11/55).3 The presence of a pseudoglandular or alveolar pattern might suggest the diagnosis of an adenocarcinoma. However, the findings of tumor lobules with a distinctly squamoid morphology, along with the presence of intercellular bridges, will point to the correct diagnosis. Furthermore, ASCC does not present with intracellular mucin, clear cells, and intermediate cells – an important distinguishing point with mucoepidermoid carcinoma. The absence of true glands also militates against the differential diagnosis of an adenosquamous carcinoma.1 Although the diagnosis of ASCC may be established through histomorphology alone, p40 immunohistochemistry – a useful marker for squamous cell differentiation - strengthens the diagnosis.4 Loss of E-Cadherin expression – a protein involved in cell adhesion and binding - is usually seen in the discohesive cells but may be retained in the well differentiated areas.2 Absence of staining with mucicarmine and CD34 will help rule out mucoepidermoid carcinoma and angiosarcoma, respectively.1,2 The authors felt that the latter two differential diagnoses could be excluded on the basis of the light microscopic features present in the case along with the demonstration of diffuse p40 positivity. It is granted however that in resource-rich settings, these other ancillary diagnostic tests may prove helpful especially for morphologically ambiguous cases or cases with less tissue volume. Current studies show no statistically significant difference in the overall survival rate of ASCCs versus that of conventional SCC.3 ASCC is treated in the same manner as conventional SCC.1 The importance of recognizing this variant lies in ensuring that it is not mistaken for its other non-squamous morphological mimics.
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47

Igarramen, Tariq, Youness Elkhadir, Ghita Elhadraoui, Oumayma Bounid, Sanae Chaouia, Mouna Darfaoui, Abdelhamid El Omrani, and Mouna Khouchani. "Locally Advanced Squamous Cells Carcinoma of the Maxillary Sinus: A Case Showing Complete Response to Exclusive Chemoradiotherapy." Scholars Journal of Medical Case Reports 9, no. 10 (October 2, 2021): 933–37. http://dx.doi.org/10.36347/sjmcr.2021.v09i10.003.

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Maxillary sinus squamous cell carcinoma is the most frequent type of Maxillary sinus carcinoma, and over 80% of Maxillary sinus squamous cell carcinomas are detected at an advanced stage because of a lack of typical symptoms, and making curative surgery sometimes impossible. We report a case of advanced squamous cell carcinoma of the left maxillary sinus, which had an aggressive clinical course but a complete response to chemoradiation. A discussion of the clinical course and treatment of squamous cell carcinoma is presented, along with a review of the pertinent literature.
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48

Driver, Brandon R., Bryce P. Portier, Dina R. Mody, Michael Deavers, Eric H. Bernicker, Min P. Kim, Bin S. Teh, et al. "Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria." Archives of Pathology & Laboratory Medicine 140, no. 4 (October 2, 2015): 312–17. http://dx.doi.org/10.5858/arpa.2015-0361-oa.

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The classification of pulmonary large cell carcinoma has undergone a major revision with the recent World Health Organization (WHO) 2015 Classification. Many large cell carcinomas are now reassigned to either adenocarcinoma with solid pattern or nonkeratinizing squamous cell carcinoma based on immunopositivity for adenocarcinoma markers or squamous cell carcinoma markers, respectively. Large cell carcinomas that are negative for adenocarcinoma and squamous cell carcinoma immunomarkers are now classified as large cell carcinoma with null immunohistochemical features (LCC-N). Although a few studies investigated the mutation profile of large cell carcinomas grouped by immunostain profile before the publication of the new WHO classification, investigation of tumors previously diagnosed as large cell carcinoma and reclassified according to the 2015 WHO classification has not, to our knowledge, been reported.Context.— To determine the mutation profiles of pulmonary large cell carcinomas reclassified by WHO 2015 criteria.Objective.— Archival cases of non–small cell lung carcinoma with large cell carcinoma morphology (n = 17) were reclassified according to 2015 WHO criteria. To determine mutation profile, we employed Ion Torrent (Life Technologies, Carlsbad, California)–based next-generation sequencing (50 genes; more than 2800 mutations) in addition to real-time quantitative reverse transcription polymerase chain reaction for ALK translocation detection.Design.— Two of 17 cases (12%) were reclassified as LCC-N, and both had mutations—BRAF D594N in one case and KRAS G12C in the other case. Seven of 17 cases (41%) were reclassified in the adenocarcinoma with solid pattern group, which showed one KRAS G12C and one EGFR E709K + G719C double mutation in addition to mutations in TP53. Eight of 17 cases (47%) were reclassified in the nonkeratinizing squamous cell carcinoma group, which showed mutations in PIK3CA, CDKN2A, and TP53. No ALK translocations or amplifications were detected.Results.— The adenocarcinoma with solid pattern group showed mutations typical of adenocarcinoma, whereas the nonkeratinizing squamous cell carcinoma group showed mutations typical of squamous cell carcinoma. Both LCC-N cases had mutations associated with adenocarcinoma, supporting the hypothesis that LCC-N is related to adenocarcinoma.Conclusions.—
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49

Ahmed, Saqib, Ruquiya Afrose, and Asfa Shams. "Pigmented squamous cell carcinoma of pinna: A rare case report." IP Archives of Cytology and Histopathology Research 7, no. 1 (March 15, 2022): 67–70. http://dx.doi.org/10.18231/j.achr.2022.013.

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Pigmented squamous cell carcinoma is one of the rare variants of squamous cell carcinoma accounting for 0.01 to 7% of all squamous cell carcinomas. We report a case of pigmented SCC over right pinna in a 45-year-old Indian male presenting with a brownish ulcero-fungating growth which on histopathological examination revealed atypical squamous cells with intracytoplasmic melanin pigment and interspersed basal and suprabasal melanocytes and a final diagnosis of pigmented squamous cell carcinoma was made. Ruling out the differential diagnosis is essential for both the clinical and pathologist for an accurate diagnosis and early management of the patient.
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50

Iqbal, Javeed, Arshad Ali, Issam Al-Bozom, and Abdulnasser Alyafei. "Lumbar spine metastasis from squamous cell carcinoma of tongue." International Journal of Case Reports and Images 13, no. 2 (May 6, 2022): 1–5. http://dx.doi.org/10.5348/101307z01ji2022cr.

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Introduction: Acute anterior poliomyelitis (AAP) is an endemic human disease caused by a worldwide spreading enterovirus. The late consequences of AAP include a new picture of muscle weakness together with abnormal muscle fatigue, amyotrophy, and myoarticular pain, configuring a condition known as post-polio syndrome (PPS). This new condition comprises a specific set of health problems due to the polio virus, resulting in decreased functional capacity and/or the onset of new disabilities. Case Report: A 53-year-old female, human resources analyst, reported that she had been shaken by AAP at the age of 2. Currently she was presented with gait on the knees, osteo-myoarticular pain, inadequate synergies of movements. Imaging exams showed great disproportion in the pelvic region with marked amyotrophy and liposubstitution of the muscle, more evident in the left leg. Although there was some preservation of the plantar flexor muscles, interstitial edema was evident. In the thighs there was amyotrophy with liposubstitution of the muscle, more evident on the left. In the left knee joint there was a lesion of the cruciate ligaments with extensive deep chondral erosions in the load area of the femorotibial compartment, with exposure of the subchondral bone, without edema. Osteopenia also affected it. Conclusion: Through the data obtained in this study, it can be seen that there are many reasons why patients affected by post-polio syndrome develops bone deformities and joint interferences that cause the individual to suffer losses and aggravations in health and quality of life. Nevertheless, there is a lack of theoretical framework available in the literature, justifying the importance of further studies on this topic.
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