Relevant bibliographies by topics / Squalestatin

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Academic literature on the topic 'Squalestatin'

Author: Grafiati
Published: 4 June 2021
Last updated: 13 February 2022

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Journal articles on the topic "Squalestatin"

1

Lebe, Karen E., and Russell J. Cox. "Oxidative steps during the biosynthesis of squalestatin S1." Chemical Science 10, no. 4 (2019): 1227–31. http://dx.doi.org/10.1039/c8sc02615g.

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Two enzymes of previously unknown function encoded by the squalestatin biosynthetic gene cluster from the fungus Phoma MF5453 catalyse a remarkable series of six consecutive oxidations to form the 4,8-dioxa-bicyclo[3.2.1]octane core of the squalestatins.
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Bonsch, B., V. Belt, C. Bartel, N. Duensing, M. Koziol, C. M. Lazarus, A. M. Bailey, T. J. Simpson, and R. J. Cox. "Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues." Chemical Communications 52, no. 41 (2016): 6777–80. http://dx.doi.org/10.1039/c6cc02130a.

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Roberts, Douglas M., Christoph Bartel, Alan Scott, David Ivison, Thomas J. Simpson, and Russell J. Cox. "Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming." Chemical Science 8, no. 2 (2017): 1116–26. http://dx.doi.org/10.1039/c6sc03496a.

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Gabriel, Heloisa B., Marcia F. Silva, Emília A. Kimura, Gerhard Wunderlich, Alejandro M. Katzin, and Mauro F. Azevedo. "Squalestatin Is an Inhibitor of Carotenoid Biosynthesis in Plasmodium falciparum." Antimicrobial Agents and Chemotherapy 59, no. 6 (March 16, 2015): 3180–88. http://dx.doi.org/10.1128/aac.04500-14.

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ABSTRACTThe increasing resistance of malaria parasites to almost all available drugs calls for the characterization of novel targets and the identification of new compounds. Carotenoids are polyisoprenoids from plants, algae, and some bacteria, and they are biosynthesized byPlasmodium falciparumbut not by mammalian cells. Biochemical and reverse genetics approaches were applied to demonstrate that phytoene synthase (PSY) is a key enzyme for carotenoid biosynthesis inP. falciparumand is essential for intraerythrocytic growth. The known PSY inhibitor squalestatin reduces biosynthesis of phytoene and kills parasites during the intraerythrocytic cycle. PSY-overexpressing parasites showed increased biosynthesis of phytoene and its derived product phytofluene and presented a squalestatin-resistant phenotype, suggesting that this enzyme is the primary target of action of this drug in the parasite.
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Nicolaou, Kyriacos Costa, Alan Nadin, James E. Leresche, Eddy W. Yue, and Susan La Greca. "Totalsynthese von Saragossasäure A/Squalestatin S1." Angewandte Chemie 106, no. 21 (November 3, 1994): 2312–13. http://dx.doi.org/10.1002/ange.19941062129.

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Abdel-Rahman, Hesham, Joseph P. Adams, Alastair L. Boyes, Mike J. Kelly, Darren J. Mansfield, Panayiotis A. Procopiou, Stanley M. Roberts, Deborah H. Slee, and Nigel S. Watson. "A synthetic approach to squalestatin 1." Journal of the Chemical Society, Chemical Communications, no. 24 (1993): 1839. http://dx.doi.org/10.1039/c39930001839.

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Nicolaou, K. C., Eddy W. Yue, Susan la Greca, Alan Nadin, Zhen Yang, James E. Leresche, Tatsuo Tsuri, Yoshimitsu Naniwa, and Francesco de Riccardis. "Synthesis of Zaragozic Acid A/Squalestatin S1." Chemistry - A European Journal 1, no. 7 (October 1995): 467–94. http://dx.doi.org/10.1002/chem.19950010712.

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da Silva, Marcia F., Alexandre Y. Saito, Valnice J. Peres, Antonio C. Oliveira, and Alejandro M. Katzin. "In VitroAntimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway." Antimicrobial Agents and Chemotherapy 59, no. 8 (June 8, 2015): 5084–87. http://dx.doi.org/10.1128/aac.04161-14.

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ABSTRACTPrevious studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activityin vitro. We included squalestatin, an inhibitor of the isoprenoid metabolism inErwinia uredovora, and found that combinations of compounds which act on different targets of the plasmodial isoprenoid pathway possess important supra-additivity effects.
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9

Hodgson, David M., and Hasanain A. A. Almohseni. "Evolution of a Cycloaddition–Rearrangement Approach to the Squalestatins: A Quarter-Century Odyssey." Synlett 31, no. 16 (June 4, 2020): 1555–72. http://dx.doi.org/10.1055/s-0040-1707127.

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The highs, lows, and diversions of a journey leading to two syntheses of 6,7-dideoxysqualestatin H5 is described. Both syntheses relied on highly diastereoselective n-alkylations of a tartrate acetonide enolate and subsequent oxidation–hydrolysis to provide an asymmetric entry to β-hydroxy-α-ketoester motifs. The latter were differentially elaborated to diazoketones which underwent stereo- and regioselective Rh(II)-catalysed cyclic carbonyl ylide formation–cycloaddition and then acid-catalysed transketalisation to generate the 2,8-dioxabicyclo[3.2.1]octane core of the squalestatins/zaragozic acids at the correct tricarboxylate oxidation level. The unsaturated side chain was either protected with a bromide substituent during the transketalisation or introduced afterwards by a stereoretentive Ni-catalyzed Csp3–Csp2 cross-electrophile coupling.1 Introduction 2 Racemic Model Studies to the Squalestatin/Zaragozic Acid Core3 Asymmetric Model Studies to a Keto α-Diazoester3.1 Dialkyl Squarate Desymmetrisation3.2 Tartrate Alkylation3.2.1 Further Studies on Seebach’s Alkylation Chemistry 4 Failure at the Penultimate Step to DDSQ 5 Second-Generation Approach to DDSQ: A Bromide Substituent Strategy 5.1 Stereoselective Routes to E-Alkenyl Halides via β-Oxido Phosphonium Ylides 5.2 Back to DDSQ Synthesis6 An Alternative Strategy to DDSQ: By Cross-Electrophile Coupling7 Alkene Ozonolysis in the Presence of Diazo Functionality: Accessing α-Ketoester Intermediates8 Summary
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Nicolaou, Kyriacos C., Alan Nadin, James E. Leresche, Eddy W. Yue, and Susan La Greca. "Total Synthesis of Zaragozic Acid A/Squalestatin S1." Angewandte Chemie International Edition in English 33, no. 21 (November 17, 1994): 2190–91. http://dx.doi.org/10.1002/anie.199421901.

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Dissertations / Theses on the topic "Squalestatin"

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Hassan, Awatef Mahdi. "Synthetic and biosynthetic studies on squalestatin." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388330.

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Sintim, Herman Ofosuhene. "Synthetic studies towards 6,7-dideoxysqualestatin H5." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270739.

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Hurley, Déirdre. "Investigations into the squalestatin biosynthetic gene cluster." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435424.

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Bailey, James Matthew. "Synthetic studies towards zaragozic acid A - squalestatin S1." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389086.

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Westaway, Susan Marie. "Squalestatin biosynthesis : synthesis and incorporation of assembly intermediates." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296602.

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Mansfield, Darren James. "Synthetic approaches towards Squalestatin 1 : a potent anti-hypercholesterolemic agent." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393292.

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Yao, Hao [Verfasser]. "In Vitro investigation of multi-domain fragments of squalestatin tetraketide synthase / Hao Yao." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2019. http://d-nb.info/1176105167/34.

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Glod, Frank. "PCR generated gene probes for cloning fungal polykeptide synthase genes associated with squalestatin biosynthesis." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268525.

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Lebe, Karen Elisabeth [Verfasser]. "Investigating the biosynthesis of the fungal metabolites Squalestatin S1, Strobilurin A and SCH–642305 / Karen Elisabeth Lebe." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2020. http://d-nb.info/1205068325/34.

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Miller, John Richard Anthony. "Synthesis of optically active amino-acids and some chiral compounds as intermediates to squalestatin using novel organometallic catalysts and material from the chiral pool." Thesis, University of Essex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302567.

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Books on the topic "Squalestatin"

1

Montagnon, Tamsyn. Synthetic studies towards the squalestatins. 2001.

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