Relevant bibliographies by topics / SPR - Surface Plasmon Resonance

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
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Academic literature on the topic 'SPR - Surface Plasmon Resonance'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "SPR - Surface Plasmon Resonance"

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Rizal, Conrad, Vladimir Belotelov, Daria Ignatyeva, Anatoly K. Zvezdin, and Simone Pisana. "Surface Plasmon Resonance (SPR) to Magneto-Optic SPR." Condensed Matter 4, no. 2 (May 27, 2019): 50. http://dx.doi.org/10.3390/condmat4020050.

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In this editorial, a brief background of the surface plasmon resonance (SPR) principle is discussed, followed by several aspects of magneto-optic SPR (MOSPR) and sensing schemes from the viewpoint of fundamental studies and potential technological applications. New sensitivity metrics are introduced that would allow researchers to compare the performance of SPR and MOSPR-based sensors. Merits of MOSPR over SPR based sensors and challenges faced by MOSPR sensors in terms of their practical use and portability are also considered. The editorial ends with potential new configurations and future prospects. This work is considered highly significant to device engineers, graduate and undergraduate students, and researchers of all levels involved in developing new classes of bio-devices for sensing, imaging, environmental monitoring, toxic gas detection, and surveying applications to name a few.
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Semchuk, O. Yu, O. O. Havryliuk, and A. A. Biliuk. "Kinetic theory of surface plasmon resonance in metal nanoparticles." Surface 12(27) (December 30, 2020): 3–19. http://dx.doi.org/10.15407/surface.2020.12.003.

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In recent years, interest in studying the optical properties of metallic nanostructures has grown. This interest is primarily related to the possibility of practical application of such nanostructures in quantum optical computers, micro- and nanosensors. These applications are based on the fundamental optical effect of surface plasmon excitation. The consequence of this phenomenon is surface plasmon resonance (SPR) - an increase in the cross section of energy absorption by a metal nanoparticle as the frequency of incident light (laser radiation) approaches the SPR frequency of the nanoparticle. Plasmon structures are used to improve the efficiency of thin-film SC. In such structures, metal nanoparticles can primarily act as additional scattering elements for the long-wavelength component of sunlight illuminating SC. As a collective phenomenon, SPR can be described using kinetic approaches, ie using the Boltzmann kinetic equation for the conduction electrons of metal nanoparticles. In this work, the theory of SPR based on the kinetic equation for the conduction electrons of nanoparticles is constructed. to the well-known results derived from the Drude-Sommerfeld theory. Second, the kinetic method makes it possible to study metal nanoparticles with sizes larger or ptical conductivity tensor for spheroidal metal nanoparticles. It is shown that the effect of nanoparticle asymmetry on the ratio of the components of the optical conductivity tensor differs not only smaller than the average electron free path length. The developed theory is used to calculate the oquantitatively but also qualitatively in high-frequency and low-frequency surface scattering. It was found that in metal nanoparticles in a dielectric matrix, under SPR conditions, the full width of the SPR line in a spherical metal nanoparticle depends on both the radius of the particle and the frequency of the electromagnetic (laser) radiation exciting this SPR. It is shown that oscillations of the SPR line width with a change in the dielectric constant of the medium in which they are located can be observed in metal nanoparticles. The magnitude of these oscillations is greater the smaller the size of the nanoparticle and increases significantly with increase. As the radius of the spherical nanoparticle increases, the width of the SPR line decreases significantly and prevails around a certain constant value in media with a higher value of dielectric constant.
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Wang, Xing-Yuan, Yi-Lun Wang, Suo Wang, Bo Li, Xiao-Wei Zhang, Lun Dai, and Ren-Min Ma. "Lasing Enhanced Surface Plasmon Resonance Sensing." Nanophotonics 6, no. 2 (March 1, 2017): 472–78. http://dx.doi.org/10.1515/nanoph-2016-0006.

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AbstractThe resonance phenomena of surface plasmons has enabled development of a novel class of noncontact, real-time and label-free optical sensors, which have emerged as a prominent tool in biochemical sensing and detection. However, various forms of surface plasmon resonances occur with natively strong non-radiative Drude damping that weakens the resonance and limits the sensing performance fundamentally. Here we experimentally demonstrate the first lasing-enhanced surface plasmon resonance (LESPR) refractive index sensor. The figure of merit (FOM) of intensity sensing is ~84,000, which is about 400 times higher than state-of-the-art surface plasmon resonance (SPR) sensor. We found that the high FOM originates from three unique features of LESPR sensors: high-quality factor, nearly zero background emission and the Gaussian-shaped lasing spectra. The LESPR sensors may form the basis for a novel class of plasmonic sensors with unprecedented performance for a broad range of applications.
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HORING, NORMAN J. MORGENSTERN, and H. L. CUI. "SURFACE-PLASMON-RESONANCE BASED OPTICAL SENSING." International Journal of High Speed Electronics and Systems 18, no. 01 (March 2008): 71–78. http://dx.doi.org/10.1142/s012915640800514x.

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Over the past twenty years, surface plasmon resonance has been developed as an effective technique for use in real-time biotechnological measurements of the kinetics of label-free biomolecular interactions with high sensitivity.1-16 On a fundamental level, it is the dielectric-imaging involvement of the adsorbed biomolecular layer (DNA for example) in shifting the surface plasmon resonance (SPR) frequency by means of electrostatic coupling at the interface with the metal film substrate that facilitates SPR-based optical sensing. Of course, there are various factors that can influence surface plasmon resonance, including plasma nonlocality, phonons, multiplicity of layers, all of which should be carefully examined. Moreover, tunable SPR phenomenology based on the role of a magnetic field (both classically and quantum mechanically) merits consideration in regard to the field's effects on both the substrate17 and the adsorbed layer(s).18 This paper is focused on the establishment of the basic equations governing surface plasmon resonance, incorporating all the features cited above. In it, we present the formulation and closed-form analytical solution for the dynamic, nonlocal screening function of a thick substrate material with a thin external adsorbed layer, which can be extended to multiple layers. The result involves solution of the random phase approximation (RPA) integral equation for the spatially inhomogeneous system of the substrate and adsorbed layer,19-25 given the individual polarizabilities of the thick substrate and the layer. (This is tantamount to the space-time matrix inversion of the inhomogeneous joint dielectric function of the system.) The frequency poles of the resulting screening function determine the shifted surface (and bulk) plasmon resonances and the associated residues at the resonance frequencies provide their relative excitation amplitudes. The latter represent the response strengths of the surface plasmon resonances (oscillator strengths), and will be of interest in optimizing the materials to be employed.
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Choi, Jin-Ha, Jin-Ho Lee, Joohyung Son, and Jeong-Woo Choi. "Noble Metal-Assisted Surface Plasmon Resonance Immunosensors." Sensors 20, no. 4 (February 13, 2020): 1003. http://dx.doi.org/10.3390/s20041003.

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For the early diagnosis of several diseases, various biomarkers have been discovered and utilized through the measurement of concentrations in body fluids such as blood, urine, and saliva. The most representative analytical method for biomarker detection is an immunosensor, which exploits the specific antigen-antibody immunoreaction. Among diverse analytical methods, surface plasmon resonance (SPR)-based immunosensors are emerging as a potential detection platform due to high sensitivity, selectivity, and intuitive features. Particularly, SPR-based immunosensors could detect biomarkers without labeling of a specific detection probe, as typical immunosensors such as enzyme-linked immunosorbent assay (ELISA) use enzymes like horseradish peroxidase (HRP). In this review, SPR-based immunosensors utilizing noble metals such as Au and Ag as SPR-inducing factors for the measurement of different types of protein biomarkers, including viruses, microbes, and extracellular vesicles (EV), are briefly introduced.
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Olaru, Andreea, Camelia Bala, Nicole Jaffrezic-Renault, and Hassan Y. Aboul-Enein. "Surface Plasmon Resonance (SPR) Biosensors in Pharmaceutical Analysis." Critical Reviews in Analytical Chemistry 45, no. 2 (January 6, 2015): 97–105. http://dx.doi.org/10.1080/10408347.2014.881250.

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Piliarik, Marek, and Jiří Homola. "Surface plasmon resonance (SPR) sensors: approaching their limits?" Optics Express 17, no. 19 (September 1, 2009): 16505. http://dx.doi.org/10.1364/oe.17.016505.

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Eum, Nyeon-Sik, Do-Eok Kim, Se-Hyuk Yeom, Byoung-Ho Kang, Kyu-Jin Kim, Chang-Sub Park, and Shin-Won Kang. "Variable wavelength surface plasmon resonance (SPR) in biosensing." Biosystems 98, no. 1 (October 2009): 51–55. http://dx.doi.org/10.1016/j.biosystems.2009.05.008.

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Bao, Yu, Bo Li, Yi Ran Guan, and Gui Fu Yang. "Amphetamine Detection Based on Surface Plasmon Resonance Techniques." Advanced Materials Research 143-144 (October 2010): 1056–58. http://dx.doi.org/10.4028/www.scientific.net/amr.143-144.1056.

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This paper introduced a new method for detection of amphetamine based on the Surface Plasmon Resonance (SPR) techniques. Experimental results show that SPR is approved to be a suitable approach for detection of amphetamine due to its unique properties such as label-free, real-time, high sensitivity, etc. By introducing such a SPR detection, 10μg/ml amphetamine could be easily detected and compounds with similar molecular structure are also expected suitable for SPR detection.
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Ivanov, A. S., and A. E. Medvedev. "Optical surface plasmon resonance biosensors in molecular fishing." Biomeditsinskaya Khimiya 61, no. 2 (2015): 231–38. http://dx.doi.org/10.18097/pbmc20156102231.

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An optical biosensor employing surface plasmon resonance is a highly efficient instrument applicable for direct real time registration of molecular interactions without additional use of any labels or coupled processes. As an independent approach it is especially effective in analysis of various ligand receptor interactions. SPR-biosensors are used for validation of studies on intermolecular interactions in complex biological systems (affinity profiling of various groups of proteins, etc.). Recently, potential application of the SPR-biosensor for molecular fishing (direct affinity binding of target molecules from complex biological mixtures on the optical biosensor surface followed by their elution for identification by LC-MS/MS) has been demonstrated. Using SPR-biosensors in such studies it is possible to solve the following tasks: (a) SPR-based selection of immobilization conditions required for the most effective affinity separation of a particular biological sample; (b) SPR-based molecular fishing for subsequent protein identification by mass spectrometry; (c) SPR-based validation of the interaction of identified proteins with immobilized ligand. This review considers practical application of the SPR technology in the context of recent studies performed in the Institute of Biomedical Chemistry on molecular fishing of real biological objects.
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Dissertations / Theses on the topic "SPR - Surface Plasmon Resonance"

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Du, Yao. "Particle-modified surface plasmon resonance biosensor." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289388.

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Surface plasmon resonance (SPR) biosensors have attracted great attention in scientific research in the past three decades. Extensive studies on the immobilisation of biorecognition elements have been conducted in pursuit of higher sensitivity, but trialled formats have focussed on a thin layer modification next to the plasmon film, which usually requires in situ derivatization. This thesis investigates an 'off-chip' immobilisation strategy for SPR biosensing using silica particles and considers the implications of a particle-modified evanescent field on the signal amplitude and kinetics, for an exemplar affinity binding between immobilised IgG and its anti-IgG complement. Submicron silica particles were synthesized as carriers for the bio-recognition elements. They were then immobilised to form a sub-monolayer on the gold film of an SPR biosensor using two methods: thiolsilane coupling and physical adsorption aided by mechanical pressure. The bio-sensitivity towards an antigen/antibody interaction was lower than an SPR biosensor with an alkanethiolate SAM due to the difference in ligand capacity and position in the evanescent field. The binding kinetics of antigen/antibody pair was found to follow the Langmuir model closely in a continuous flow configuration but was heavily limited by the mass transport from the bulk to the sensor surface in a stop-flow configuration. A packed channel configuration was designed with larger gel particles as ligand carriers, packed on top of a gold film to create a column-modified SPR biosensor. This sensor has comparable bio-sensitivity to the previous sub-monolayer particle-modified systems, but the binding and dissociation of the analyte was heavily dependent on mass transport and binding equilibria across the column. A bi-directional diffusion mechanism was proposed based on a two-compartment mass transport model and the expanded model fitted well with the experimental data. The column-modified sensor was also studied by SPR imaging and analyte band formation was observed and analysed. Using the lateral resolution, a multiplexing particle column configuration was explored, and its potential in distinguishing a multicomponent analyte.
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Wijaya, Edy. "Design and optimization of Surface Plasmon Resonance (SPR) biosensors." Thesis, Lille 1, 2012. http://www.theses.fr/2012LIL10096/document.

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En terme de performance, le biocapteur idéal doit avoir très grande sensibilité, basse limite de détection et temps d’analyse qui est extrêmement court. Les biocapteurs sans marquage à base de résonance de plasmons de surface (biocapteurs SPR) possèdent naturellement le temps d’analyse le plus court parmi différent types de biocapteurs. Leur limite de détection n’est cependant pas la plus impressionnante. Il y a donc un besoin pour augmenter considérablement la sensibilité intrinsèque des biocapteurs SPR afin de permettre de plus basses limites de détection. Quelques approches pour exalter la sensibilité optique des biocapteurs SPR dans la configuration « traditionnel » de Krestchmann telles que film SPR bimétallique, plasmons à longues portées et détection dans l’infrarouge proche sont examinées dans ce travail. Des configurations « non traditionnelles » comme guides optiques planaires avec couplage par réseau et structures sub-longueur d’ondes ont été aussi théoriquement étudiées. Nouvelle stratégie de fonctionnalisation de surface à base de graphène qui augmente la sensibilité de reconnaissance biomoléculaire et peut être appliquée à quasiment toute structure SPR a été également démontrée
In terms of performance, the ideal biosensor should have high sensitivity, low limits of detection, and extremely short analysis time. Label-free surface plasmon resonance (SPR) biosensors naturally offer the shortest analysis time compared to other types of biosensors. On the other hand, the limits of detection of SPR biosensors are not the most impressive. The inherent sensitivity of SPR biosensors thus needs to be significantly improved to allow lower limits of detection. Several approaches for the enhancement of optical sensitivity of SPR biosensors in the “traditional” attenuated total reflection (ATR) Kretschmann configuration such as the use of bimetallic SPR film, long-range surface plasmons, and near-infrared operating wavelength have been investigated in this work. In addition, some “non traditional” configurations for SPR biosensors including grating-coupled planar optical waveguides and arrays of sub-wavelength structures have been theoretically studied. Novel graphene-based surface functionalization strategy with enhanced biorecognition sensitivity that can be applied to virtually any SPR structure has also been demonstrated
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Prabhu, G. Radhakrishna. "Studies On Surface Plasmon Resonance And Related Experimental Methods Using Fixed Plasmon Angle." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/205.

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Surface plasmon waves are transverse magnetic electromagnetic waves propagating along a dielectric-metal interface. These waves can be excited by resonant absorption of electromagnetic radiation leading to surface plasmon resonance (SPR) at the interface. The resonance is characterised by a reduction in the intensity of the reflected light at the interface due to strong coupling of incident optical radiation to surface plasmons. This gives rise to a minimum at a sharply defined angle of incidence, referred to as SPR angle or plasmon angle. The phenomenon of SPR has been extensively used in the past to develop reflective type optical devices for sensing applications on account of the high dielectric function dependent sensitivity of the SPR angle. Basically, devices which exhibit this phenomenon have a structure consisting of a metal film sandwiched between two dielectrics. The reflectivity of such a device is theoretically modelled based on either theory of thin films (Fresnel's model) or theory of resonance (Lorentzian model). These models have very effectively predicted the behaviour of such devices based on the shift in SPR angle due to the dielectric function variations. We have been investigating the SPR device for intensity based metrological applications utilising its high angular sensitive reflectivity, with fixed SPR angle. In these intensity based applications or measurements, direct and simple expressions connecting intensity variation to angular change are unavailable in the literature and quantitative estimation or data inversion is based on either curve fitting or iterative methods. Fresnel and Lorentzian models have commonly been used in the experiments but data inversion through the Fresnel model is computationally complex and the Lorentzian model, although less complicated, gives erroneous results due to its approximate nature. In order to obtain a simple expression between intensity variation and the angular change, we have re-looked at the two existing models in order to derive an expression which has the simplicity of the Lorentzian model and the accuracy of the Fresnel model in the experiments with fixed plasmon angles. These efforts have been particularly directed to understand the relationship between intensity variation and meteorologically important properties of such devices. This thesis is an attempt to summarize the computational results which have led us to some novel experimental methodologies which have been used to exploit these devices for inverse type, illumination specific, SPR based applications. The work presented in this thesis is organised in six chapters. Chapter 1, gives an overview of optical sensing, theory of surface plasmons, excitation schemes for surface plasmons, development of the SPR device and its characterisation. It also includes a brief literature review in the area of surface plasmon resonance, covering both the theoretical and experimental aspects. The objectives of the work and the scope of the thesis are also presented. Chapter 2 presents the existing models of SPR device, based on Fresnel's and the Lorentzian models. These models allow reflectance calculations from knowledge of either the optical parameters that describe the layers or the parameters of the waves that propagate through them. Using these models, the inverse problem of estimating either the angle of incidence or the optical constants of the layers of the sensors utilizing the intensity based measurements is generally difficult. In order to solve this problem where the plasmon angles are fixed, a modified formalism for the angle scanned SPR spectrum of a three-layered SPR sensor is presented in this chapter. The new formalism regroups the wave vector parameters of Lorentzian resonance theory into a set of non-dimensional parameters 1, 4K and R. The new reflectivity index (1), which is the ratio of reflectance to the absorptance, has been introduced to help explain the physical processes underlying the device operation in the high sensitivity region of the characteristics. The parameter 4Kis a constant of the device and it depends on the dielectric constants of the device. This is a new SPR index and is identified at a point where reflectance and absorptance match. Parameter R is related to the loss mechanisms in the device and will be explained in detail in Chapter 3. This simple model links the new reflectivity index (1) to the angular detune from SPR angle (ΔƟ) and it brings out a parabolic variation of ΔƟ with 1. In this chapter the mathematical derivation of the proposed model is presented and the significance of the new parameters 1, 4Kand Rare discussed. Chapter 3 evaluates the characteristic nature of errors associated with the predictions from the proposed model and presents methods for neutralizing them. It is demonstrated with the help of the function K which is linearly dependant on 1, that the proposed model predicts the reflectance from the wave vector parameters as accurately as the Fresnel's model. This R parameter explains the slowly varying nature of the radiative loss with the angle of incidence and this variation contributes significantly to the SPR characteristics. As a consequence, it is found that the SPR characteristics can be represented as a sum of two primary functions which are parabolic and linear, respectively, and this leads to the easy explanation of the SPR characteristics. The present chapter also discusses a new observation that the angle-scanned SPR spectrum can be accurately described using a straight line in intercept form. The intercept value depends on 4Kand the slope depends on K. In addition to this, this chapter discusses practical methods for estimation of the intercept and the slope of such a straight line which are functions of the key wave vector parameters. A detailed discussion on the proposed model highlighting its advantages for inverse type, illumination specific, SPR-based applications with fixed SPR angle is also presented. Chapter 4 describes the applications of the proposed model for optical constant measurements. The first part highlights a new approach for the determination of the dielectric constants of the metal film used for the optimised- or nearly-optimised SPR sensors using the proposed model. In the complex dielectric constant, the real part is calculated from the SPR angle and the imaginary part from 4K. A discussion on the dielectric constant study of silver and gold metal film is presented. The advantages of the proposed approach such as its simplicity and direct methodology are then discussed. The second part of the chapter also proposes a new approach to carry out measurements on the absorbance of the medium with enhanced sensitivity utilising the parameter 4K It describes a computational study on the variation of 4K values with the dielectric function and highlights the relationship of 4K variation due to the imaginary part of the dielectric function (absorption) of the samples. The physical processes causing a change in the value of 4Kdue to absorption is also discussed along with some computational results. Chapter 5 reports the study carried out to bring out the importance of the new index,4K in metrological applications. Based on the new model, the effect of the laser beam divergence on SPR curve is studied. This chapter first of all discusses the design of the SPR device and the new methods for the development and characterisation of such a device. Details of the experimental procedure for laser divergence evaluation are proposed along with some of the significant computational results. Furthermore, a few applications such as focal length measurement of optical lenses, micro-displacement measurement based on the divergence of the laser beam are also reported. Since the SPR characteristics can be represented easily using the new model, the angular dependent intensity variation can be utilised for some metrological applications with simple data processing. In this context, the high angular sensitivity of the SPR device is studied and some applications such as micro-displacement measurement, pressure measurement and optical wedge angle measurement are included to highlight the above advantages. The last chapter, Chapter 6, gives a summary and conclusions of the work presented in the thesis. The scope for future investigations is also included in this chapter.
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See, Erich Michael. "Modeling Plasmon Resonance for a Gold Nanoparticle Plasmon-Enhanced Cadmium Sulfide Biosensor." Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1249499557.

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Bang, Hyungseok. "INTEGRATED OPTICAL SPR (SURFACE PLASMON RESONANCE) SENSOR BASED ON OPTOELECTRONIC PLATFORM." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3289.

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Current major demands in SPR sensor development are system miniaturization and throughput improvement. Structuring an array of integrated optical SPR sensor heads on a semiconductor based optoelectronic platform could be a promising solution for those issues, since integrated optical waveguides have highly miniaturized dimension and the optoelectronic platform enables on-chip optical-to-electrical signal conversion. Utilizing a semiconductor based platform to achieve optoelectronic functionality poses requirements to the senor head; the sensor head needs to have reasonably small size while it should have reasonable sensitivity and fabrication tolerance. This research proposes a novel type of SPR sensor head and demonstrates a fabricated device with an array of integrated optical SPR sensor heads endowed with optoelectronic functionality. The novel integrated optical SPR sensor head relies on mode conversion efficiency for its operational principle. The beauty of this type of sensor head is it can produce clear contrast in SPR spectrum with a highly miniaturized and simple structure, in contrast to several-millimeter-scale conventional absorption type or interferometer type sensor heads. The integrated optical SPR sensor with optoelectronic functionality has been realized by structuring a dielectric waveguide based SPR sensor head on a photodetector-integrated semiconductor substrate. A large number of unit sensors have been fabricated on a substrate with a batch fabrication process, which promises a high throughput SPR sensor system or low-priced disposable sensors.
Ph.D.
Optics and Photonics
Optics and Photonics
Optics PhD
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Bathae, Kumaresh Prasanth. "OPTIMIZATION OF A DUAL-MODE SURFACE PLASMON RESONANCE SENSOR." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_theses/424.

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Surface plasmon waves are TM polarized charge density waves that propagate at the interface of two media with real dielectric constants of opposite sign (i.e. liquid dielectric and certain metals). Surface plasmon resonance (SPR) sensors use these waves to detect refractive index changes adjacent to the metal layer. Refractive index changes arise from the binding of an analyte (e.g. a target molecule, protein, or bacterium) to the functionalized metal layer or from interfering effects such as changes in solution index. Standard, single channel SPR sensors cannot differentiate these two effects as their design allows only one mode to be coupled. This novel self-referencing technique employs two surface plasmon modes to simultaneously measure surface binding and solution refractive index. Dual surface plasmon modes are achieved by matching the refractive indices on either side of the metal film. The two modes generated - symmetric, long-range surface plasmon (LRSP) and anti-symmetric, short-range surface plasmon (SRSP) - have different field profiles and hence assist in differentiating solution refractive index changes from surface layer formation. Amorphous Teflon, with a refractive index close to water, is chosen as the buffer layer and gold is chosen as the metal layer. Magnesium fluoride, with a higher index than Teflon, is used as the buffer layer when using ethanol as the base solution. The sensor operation was optimized through simulations to yield higher sensitivity, lower reflectivity and resonances within the spectrometers range. Optimization results showed good performance over a wide range for Teflon, MgF2 and gold thicknesses which helped in the fabrication of the sensor. Demonstration of self-referencing operation was done through two different sets of experiments: (1) formation of an alkanethiol self-assembled monolayer on gold in the presence of ethanol and methanol solutions having different refractive indices and (2) streptavidin-biotin binding with solutions of different NaCl concentration and thus different refractive indices. In both these experiments, the resonance wavelengths were accurately predicted, reflectivity varied by 10-15% and sensitivity by 25% from that of the simulated values.
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Badjatya, Vaibhav. "TUNABLE LASER INTERROGATION OF SURFACE PLASMON RESONANCE SENSORS." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_theses/588.

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Surface plasmons are bound TM polarized electromagnetic waves that propagate along the interface of two materials with real dielectric constants of opposite signs. Surface plasmon resonance (SPR) sensors make use of the surface plasmon waves to detect refractive index changes occurring near this interface. For sensing purposes, this interface typically consists of a metal layer, usually gold or silver, and a liquid dielectric. SPR sensors usually measure the shift in resonance wavelength or resonance angle due to index changes adjacent to the metal layer. However this restricts the limit of detection (LOD), as the regions of low slope (intensity vs. wavelength or angle) in the SPR curve contain little information about the resonance. This work presents the technique of tunable laser interrogation of SPR sensors. A semiconductor laser with a typical lasing wavelength of 650nm was used. A 45nm gold layer sputtered on a BK7 glass substrate served as the sensor. The laser wavelength is tuned to always operate in the region of highest slope by using a custom-designed LabVIEW program. It is shown that the sensitivity is maximized and LOD is minimized by operating around the region of high slope on the SPR curve.
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Subramanian, Kannan. "Kinetics of insulin - insulin receptor interaction using a surface plasmon resonance (SPR)." Thesis, University of Canterbury. Chemical and Process Engineering, 2014. http://hdl.handle.net/10092/9327.

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Type 2 diabetes or adult onset diabetes, has been a global epidemic for the past two decades, and the number of new cases accelerates every year. Insulin resistance is one of the major factors behind this, wherein the insulin receptor, which signals to regulate glucose levels, based on the hormone insulin, loses its sensitivity. Obesity is one other major concern which is caused due to the improper balance between the caloric intake and the energy utilized. Gastric bypass surgeries (GBP) are performed to avert obesity. However, a beneficial side-effect is that the state of insulin resistance is reset to near baseline levels within a few days after the procedure. The reason behind this remains unexplained, with possible humoral effects, hypothesized to occur after the bariatric procedure. In this work, high-five insect cell line was utilized to recombinantly produce full length insulin receptors (IR). However commercially sourced IR ectodomains (eIR – soluble version of the full length IR with the completely extracellular α subunits along with extracellular and transmembrane regions of the β subunit), were used to study the interaction. Measuring the kinetics of IR-insulin interactions is critical to improving our understanding of this disease. In this study, a multiplex surface plasmon resonance (SPR) assay was developed for studying the interaction between insulin and the eIR. A scaffold approach was used in which anti-insulin receptor monoclonal antibody 83–7 (Abcam, Cambridge, UK) was first immobilized on the SPR sensorchip by amine coupling, followed by eIR capture. The multiplex SPR system (ProteOn XPR36TM, Bio-Rad Laboratories, Hercules, CA) enabled measurement of replicate interactions with a single, parallel set of analyte injections, whereas repeated regeneration of the scaffold between measurements caused variable loss of antibody activity. The main approach was to replicate the physiological IR-insulin interaction using this assay. It was also observed that insulin at higher concentrations tend to form dimers and hexamers in solution. This was tested using size exclusion chromatography analysis and proved to be true. Therefore an alternative analyte with the similar binding properties and affinity of insulin and at the same time with reduced self- association characteristics was explored. Lispro, the analogue of insulin with reduced self-association properties (generated by swapping of residue 28 and 29 with Lys and Pro respectively) was finally used to study the interaction with eIR. Interactions between recombinant human insulin with eIR-A (A isoform of the insulin receptor ectodomain) followed a two-site binding pattern (consistent with the literature), with a high-affinity site (dissociation constant KD1 = 38.1 ± 0.9 nM) and a low-affinity site (KD2 = 166.3 ± 7.3 nM). The predominantly monomeric insulin analogue Lispro had corresponding dissociation constants KD1 =73.2 ± 1.8 nM and KD2 =148.9 ± 6.1 nM, but the fit to kinetic data was improved when conformational change factor was included in which the high-affinity site was converted to the low-affinity site. Kinetics of interaction of insulin with eIR-A and eIR-B isoforms were then compared. eIR-A bound insulin with apparently higher affinity (with both the binding sites) when compared with eIR-B. This was again consistent with literature that IR-A had two-fold higher affinity for binding insulin than IR-B. The assay was further extended to study the effect of external factors such as glucose, visfatin on this interaction. Glucose (the main biomolecule which is regulated by the IR-insulin interaction) was tested, if it had any direct effect on the interaction. It was observed that glucose did not have any effect on eIR-insulin interactions. Visfatin, an adipocytokine which has been highly debated in literature for its insulin mimetic effects and IR binding properties, was then tested. The standard assay did not provide much insights as the reference channel immobilized with 83-7 monoclonal antibody to the receptor had much affinity for visfatin, leading to non-specific binding and negative responses. Therefore, in an alternative methodology was used - visfatin, Lispro and insulin were immobilized on separate channels along with bovine serum albumin immobilized on reference channel and eIR isoforms used as analyte to study the effect of visfatin on IR. This study showed that visfatin, a higher molecular weight protein compared to insulin, bound both the eIR isoforms. This is consistent with literature that visfatin binds IR at a site distinct from insulin, but the assay described here could not confirm the fact that it mimicked the signalling carried out by IR-insulin binding. Further studies are required to interpret the kinetics of visfatin-eIR interaction. To my knowledge, this is the first SPR assay developed to study eIR-insulin interactions in real-time. This could potentially be extended to study the interaction of insulin with full length insulin receptors and the effect of humoral and other external factors on the interaction, without the need for insulin labelling.
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Earp, Ronald Lee Jr. "Multiwavelength Surface Plasmon Resonance Sensor Designs for Chemical and Biochemical Detection." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30581.

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Surface plasmon resonance (SPR) sensors using multiwavelength light coupling are investigated to probe changes in refractive index that occur as a result of chemical or biochemical processes. Traditional SPR sensors have used angle modulation to facilitate detection at the sensor surface; however, the multiwavelength approach is novel and brings new functionality to SPR sensors. The multiwavelength sensors are constructed on both fiber optic and bulk waveguides such as prisms. A thin metal film is deposited on the waveguide surface to support the surface plasmon (SP) mode. The evanescent field produced by light propagating through the waveguide can be coupled into the surface plasmon mode thus attenuating the transmitted light. This coupling is dependent upon phase matching between the light wavevector and the surface plasmon wavevector. The wavevectors are directly related to the wavelength of light, thickness of analyte on the sensor surface and the refractive index of the analyte. As these parameters change, the light output from the sensor will be affected. Other thin films can be subsequently deposited on the metal to functionalize the sensor surface for a particular analyte of interest. A theoretical background and details of the sensor construction is given. The developed sensors are tested in a variety of application systems. Experimental results for refractive index sensing in bulk liquid applications is shown. Observed sensitivity approaches that of conventional SPR techniques. Alkyl-thiol monolayer systems are studied to investigate kinetics of formation and the thickness resolution of the sensor. A biochemical system is investigated to compare the sensors with other immunoassay techniques. Ionic self-assembled monolayer (ISAM) systems are investigated to probe structure and determine their usefulness as an immobilization layer for biochemical species. A mathematical model based on Fresnel reflection equations is developed to predict sensor response. This model can be used to selectively vary sensor parameters to optimize the response for a specific analyte system or to calculate system parameters based on experimental results. Results from the various experiments are compared with the model. Experimental results and interpretations are discussed along with future work and potential improvements. Classical SPR sensors are also discussed along with comparisons with the multiwavelength sensors. Future improvements to SPR sensors design are considered, as is the application of the technology to high-throughput drug screening for pharmaceuticals.
Ph. D.
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Nordström, Helena. "Fragment Based Drug Discovery with Surface Plasmon Resonance Technology." Doctoral thesis, Uppsala universitet, Biokemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209136.

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Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. The focus of the two projects was different. Many MMP inhibitors contain a strong zinc chelating group, hydroxamate, interacting with the catalytic zinc atom. This strategy may be the cause for the low specificity of MMP inhibitors. Using FBDD we found a fragment with an unusual strong affinity for MMP-12. An inhibition assay confirmed that it was an inhibitor but indicated a stoichiometry of 2:1. Crystallography data revealed that an adduct of the fragment was bound in the active site, with interactions both with the catalytic zinc and the S1’ pocket. This may present a new scaffold for MMP-12 inhibitors. For HIV-1 protease the focus was on identifying inhibitors not sensitive to current resistance mutations. A fragment library for screening with SPR-technology was designed and used for screening against wild type enzyme and three variants with resistance mutations. Many of the hits were promiscuous but a number of fragments with possible allosteric inhibition mechanism were identified. The temperature dependency of the dissociation rate and reported resistance mutations was studied with thermodynamics. A good, but not perfect correlation was found between resistance and both the dissociation data and the free energy for dissociation compared to data from wild type enzyme. However, the type of mutation also influenced the results. The flap mutation G48V displayed thermodynamic profiles not completely correlating with resistance. It was found that dissociation rate and thermodynamics may complement each other when studying resistance, but only one of them may not be enough.
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Books on the topic "SPR - Surface Plasmon Resonance"

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Mol, Nico J., and Marcel J. E. Fischer, eds. Surface Plasmon Resonance. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-670-2.

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Oliveira, Leiva Casemiro, Antonio Marcus Nogueira Lima, Carsten Thirstrup, and Helmut Franz Neff. Surface Plasmon Resonance Sensors. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14926-4.

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Oliveira, Leiva Casemiro, Antonio Marcus Nogueira Lima, Carsten Thirstrup, and Helmut Franz Neff. Surface Plasmon Resonance Sensors. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-17486-6.

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Homola, Jiří, ed. Surface Plasmon Resonance Based Sensors. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/b100321.

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Schasfoort, Richard B. M., ed. Handbook of Surface Plasmon Resonance. Cambridge: Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/9781788010283.

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Schasfoort, Richard B. M., and Anna J. Tudos, eds. Handbook of Surface Plasmon Resonance. Cambridge: Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847558220.

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Surface plasmon resonance: Methods and protocols. New York: Humana Press, 2010.

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Long, Yi-Tao, and Chao Jing. Localized Surface Plasmon Resonance Based Nanobiosensors. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54795-9.

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Stepanov, Andrey L. Surface plasmon polariton nanooptics. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Zaheer, Sameer Mahmood, and Ramachandraiah Gosu, eds. Methods for Fragments Screening Using Surface Plasmon Resonance. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1536-8.

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Book chapters on the topic "SPR - Surface Plasmon Resonance"

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Homola, Jiří, and Marek Piliarik. "Surface Plasmon Resonance (SPR) Sensors." In Springer Series on Chemical Sensors and Biosensors, 45–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/5346_014.

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Vaithilingam, Krishnakumar, and Sameer Mahmood Zaheer. "Preparation of SPR Sensor." In Methods for Fragments Screening Using Surface Plasmon Resonance, 59–68. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1536-8_8.

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Zaheer, Sameer Mahmood, and Aswathy Pillai. "Screening of Fragments in SPR." In Methods for Fragments Screening Using Surface Plasmon Resonance, 93–97. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1536-8_12.

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Zaheer, Sameer Mahmood, and Aswathy Pillai. "Preparation of Fragments for Screening in SPR." In Methods for Fragments Screening Using Surface Plasmon Resonance, 85–91. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1536-8_11.

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Haseley, Simon R., Johannis P. Kamerling, and Johannes F. G. Vliegenthart. "Unravelling Carbohydrate Interactions with Biosensors Using Surface Plasmon Resonance (SPR) Detection." In Host-Guest Chemistry, 93–114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-45010-6_3.

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Drescher, Dennis G., Selvakumar Dakshnamurthy, Marian J. Drescher, and Neeliyath A. Ramakrishnan. "Surface Plasmon Resonance (SPR) Analysis of Binding Interactions of Inner-Ear Proteins." In Methods in Molecular Biology, 165–87. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3615-1_10.

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Drijfhout, J. W., D. J. v. d. Heuvel, W. Bloemhoff, G. W. Welling, and R. P. H. Kooyman. "An improved method to study peptide-protein interaction by surface plasmon resonance (SPR)." In Peptides, 936–37. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_314.

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Jangid, Manish, Ankur Saharia, Nitesh Mudgal, Sajai Vir Singh, and Ghanshyam Singh. "Performance Enhancement of Surface Plasmon Resonance (SPR) Structure Using a Sinusoidal Diffraction Grating." In Lecture Notes in Electrical Engineering, 123–32. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2818-4_13.

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Jay-Allemand, Christian, Nathalie Rugani, Ruba Nasri, and Luc P. R. Bide. "Detection of Biomolecules Using Surface Plasmon Resonance (SPR) Technology for Food Quality and Traceability." In Food Traceability and Authenticity, 180–95. Boca Raton, FL : CRC Press, 2017. | Series: Food biology series | “A science publishers book.”: CRC Press, 2017. http://dx.doi.org/10.1201/9781351228435-10.

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Chandran, Neeli, Manikanta Bayal, Rajendra Pilankatta, and Swapna S. Nair. "Tuning of Surface Plasmon Resonance (SPR) in Metallic Nanoparticles for Their Applications in SERS." In Nanomaterials for Luminescent Devices, Sensors, and Bio-imaging Applications, 39–66. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-5367-4_4.

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Conference papers on the topic "SPR - Surface Plasmon Resonance"

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Sathiyamoorthy, K., and Michael C. Kolios. "Gold-nanoshells as surface plasmon resonance (SPR)." In SPIE BiOS, edited by Gerard L. Coté. SPIE, 2015. http://dx.doi.org/10.1117/12.2080303.

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Kingston-O'Connell, Larry, Yoann Roupioz, and Pierre Marcoux. "Optical bacteriophage susceptibility testing by SPR (surface plasmon resonance)." In Plasmonics in Biology and Medicine XVIII, edited by Tuan Vo-Dinh, Ho-Pui A. Ho, and Krishanu Ray. SPIE, 2021. http://dx.doi.org/10.1117/12.2578753.

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Yaney, Perry P., Fahima Ouchen, and James G. Grote. "Exploring surface plasmon-polariton resonance (SPR) in an interferometer configuration." In SPIE Nanoscience + Engineering, edited by Norihisa Kobayashi, Fahima Ouchen, and Ileana Rau. SPIE, 2015. http://dx.doi.org/10.1117/12.2193792.

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Masson, Jean-Francois, Sandy Shuo Zhao, Natalia Bukar, Joelle N. Pelletier, Jérémie Labrecque-Carbonneau, Kristy McKeating, and Hélène Yockell-Lelièvre. "Surface plasmon resonance (SPR) sensing for small molecules in biofluids." In Optical Sensors. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/sensors.2015.sew1b.2.

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Syed, Maarij, Chris Leibs, and Azad Siahmakoun. "Surface Plasmon Resonance (SPR) Effect in Nanoscale Nichrome Alloy Films." In 2008 17th Biennial University/Government/Industry Micro/Nano Symposium. IEEE, 2008. http://dx.doi.org/10.1109/ugim.2008.72.

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Kashyap, Ritayan, Ananya Bhattacharjee, Khargeswar Rangpi, Noman Hanif Barbhuiya, and Biplob Mondal. "Portable surface plasmon resonance (SPR) measurement device for sensing applications." In 2020 IEEE 17th India Council International Conference (INDICON). IEEE, 2020. http://dx.doi.org/10.1109/indicon49873.2020.9342276.

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Maphanga, Charles, Saturnin Ombinda-Lemboumba, Sello Manoto, and Patience Mthunzi-Kufa. "Surface plasmon resonance (SPR) based biosensor for mycobacterium tuberculosis diagnosis." In Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics, edited by Gerard L. Coté. SPIE, 2021. http://dx.doi.org/10.1117/12.2578728.

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Wong, Chi Lok, George Chen, and Beng Koon Ng. "Two-dimensional Surface Plasmon Resonance (SPR) Biosensor based on Infrared Imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/omp.2011.otua5.

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Haque, Tauhidul, and Hasan Khaled Rouf. "A Performance Improved Kretschmann Configuration Based Surface Plasmon Resonance (SPR) Sensor." In 2019 1st International Conference on Advances in Science, Engineering and Robotics Technology (ICASERT). IEEE, 2019. http://dx.doi.org/10.1109/icasert.2019.8934489.

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Konduru, Vinaykumar, Dong Hwan Shin, Chang Kyoung Choi, and Jeffrey Allen. "VISUALIZATION OF DROPWISE CONDENSATION USING SURFACE PLASMON RESONANCE (SPR) REFLECTANCE MICROSCOPY." In First Thermal and Fluids Engineering Summer Conference. Connecticut: Begellhouse, 2016. http://dx.doi.org/10.1615/tfesc1.mph.012945.

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Reports on the topic "SPR - Surface Plasmon Resonance"

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Sanchez, Erik. Modeling of the Surface Plasmon Resonance (SPR) Effect for a Metal-Semiconductor (M-S) Junction at Elevated Temperatures. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.6508.

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McWhorter, C. S. Surface Plasmon Resonance Spectroscopy-Based Process Sensors. Office of Scientific and Technical Information (OSTI), September 2003. http://dx.doi.org/10.2172/815565.

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Zheng, Junwei. Surface plasmon enhanced interfacial electron transfer and resonance Raman, surface-enhanced resonance Raman studies of cytochrome C mutants. Office of Scientific and Technical Information (OSTI), November 1999. http://dx.doi.org/10.2172/754842.

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Anderson, B. B. Feasibility Study for the Development of a Surface Plasmon Resonance spectroscopy-based Sensor for the BNFL-Hanford. Office of Scientific and Technical Information (OSTI), July 2000. http://dx.doi.org/10.2172/759145.

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