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Dissertations / Theses on the topic 'Sporadic'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Koh, Yun Sing, and n/a. "Generating sporadic association rules." University of Otago. Department of Computer Science, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070711.115758.

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Association rule mining is an essential part of data mining, which tries to discover associations, relationships, or correlations among sets of items. As it was initially proposed for market basket analysis, most of the previous research focuses on generating frequent patterns. This thesis focuses on finding infrequent patterns, which we call sporadic rules. They represent rare itemsets that are scattered sporadically throughout the database but with high confidence of occurring together. As sporadic rules have low support the minabssup (minimum absolute support) measure was proposed to filter

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2

Robertson, Brent 1962. "The epidemiology of sporadic cryptosporidiosis." Monash University, Dept. of Epidemiology and Preventive Medicine, 2001. http://arrow.monash.edu.au/hdl/1959.1/8968.

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3

Cameron, Smail Ruaridh. "Axonal excitability in sporadic migraine." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/26808.

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Migraine is a common yet debilitating condition worldwide, affecting individuals, particularly women, of working age, causing significant impacts on quality of life and productivity. In this study, we set out to evaluate a group of individuals with sporadic migraine. We aimed to evaluate the effect of botulinum toxin or the novel calcitonin gene-related peptide (CGRP) erenumab. We were also able to consider studies on patients with familial hemiplegic migraine, where we were particularly looking to see if there were alterations in axonal excitability related to the gene mutations. A study ha

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4

Gottschalk, Harald. "Amalgams for the O'Nan Sporadic Group." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964667029.

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5

Arnardơttir, Snjơlaug. "Studies in sporadic inclusion body myositis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-572-7/.

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6

Bradley, John David. "Symmetric presentations of two sporadic groups." Thesis, University of Birmingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422333.

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7

Khudhur, Peshawa Mohammed. "Sporadic simple groups of low genus." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6592/.

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Let X be a compact connected Riemann surface of genus g and let f∶ X →P1 be a meromorphic function of degree n. Classes of such covers are in one to one correspondence with the primitive systems, which are tuples of elements (x1,x2,⋯,xr) in the symmetric group Sn taken up to conjugation and the action of the braid group, such that x1.x2.⋯.xr=1 and G=〈x1,x2,⋯,xr〉 is a primitive subgroup G of Sn. This thesis is a contribution to the classification of primitive genus g ≤ 2 systems of sporadic almost simple groups.

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8

Brown, Iain. "Gene therapy for sporadic ovarian cancer." Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602008.

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Ovarian cancer accounts for more deaths than all other gynaecological cancers taken together. The 5 year survival rate can be as high as 80% for cases diagnosed early, but the asymptomatic nature of the disease means that it is most frequently detected in the later stages. By this time, disease has invariably spread beyond the ovaries and the survival rate drops to around 30%. Treatment of ovarian cancer often fails due to a high rate of chemoresistance and novel methods of treatment and detection are required to increase the survival chances of patients. This study sought to determine whether

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9

Curtis, Lucy Jane. "Genomic instability in sporadic colorectal cancer." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21178.

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This thesis has examined aspects of two forms of instability prominent in sporadic colorectal cancer, microsatellite instability (MSI) and chromosomal instability. Microsatellite instability describes a phenotype in which mutation of microsatellite sequences is widespread, probably due to defects of components of the mismatch repair pathway. Clonal chromosomal abnormalities, frequently observed in sporadic colorectal cancer, probably arise because of instability at the chromosomal level, and there is substantial, though not conclusive, evidence that they may result from defects of the p53 prot

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10

Eversley, Chevonne D. Threadgill David W. "Integrative genomic analysis of sporadic colorectal cancer." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2874.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.

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11

Richardson, Philip Jonathan. "Sporadic geometries and their universal representation groups." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313684.

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12

Thorpe, Alison Jane. "Autoantibodies in hereditary and sporadic breast cancer." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546524.

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13

Collins, N. "BRCA2 in familial and sporadic breast cancer." Thesis, Institute of Cancer Research (University Of London), 2000. http://publications.icr.ac.uk/10070/.

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The breast cancer susceptibility gene BRCA2 is located on chromosome 13q 12-13. Using breast and ovarian cancers from a BRCA2-linked family, loss of the wild type BRCA2 allele was demonstrated in seven out of eight informative cases (87.5%) indicating that BRCA2 was a recessive oncogene. Analysis of 73 sporadic breast tumours and 12 breast cancer cell lines revealed loss of heterozygosity (LOH) in 22 (30%) of the primary tumours and seven (58%) of the breast cancer cell lines. However, it was not clear from these studies that the target for the observed LOH was the gene BRCA2 or RBl at chromos

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14

Tilley, Louise. "Genetic risk factors in sporadic Alzheimer's disease." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311748.

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15

Ryba, A. J. E. "Algebras related to some sporadic simple groups." Thesis, University of Cambridge, 1985. https://www.repository.cam.ac.uk/handle/1810/272929.

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16

Shabrokh, Elika. "Mitochondrial Biology in Sporadic Inclusion Body Myositis." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/47782.

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Sporadic Inclusion Body Myositis (sIBM) is an inflammatory muscle disease that strikes individuals at random and accounts for approximately 1/3 of all idiopathic inflammatory myopathies. It is characterized by progressive weakness of distal and proximal muscles and is the most common muscle disorder in individuals over 50 years of age. Currently, there is no known cause, cure, or enduring treatment for sIBM, although a number of theories as to its cause have been proposed. One theory proposes that activation of the inflammatory/ immune response is the primary trigger resulting in muscle deg

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17

Boggild, Michael Derek. "Molecular genetic studies of sporadic pituitary adenomas." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34167.

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Tumour formation may result from the activation of dominant oncogenes or by inactivation of recessive, tumour suppressor genes. The role of such mutations in the development of pituitary tumours has been studied. Tumours from 88 patients, representing the 4 major classes of pituitary adenoma, were investigated. In DNA extracted from matched leucocyte and tumour samples allelic deletions were sought with 15 probes identifying restriction fragment length polymorphisms on chromosomes 1, 5, 10, 11, 13, 17, 20 and 22. Evidence of amplification or re-arrangement of 10 recognised cellular oncogenes (

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18

Harris, Elena Yavorska. "Symmetric representation of elements of sporadic groups." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2844.

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Uses the techniques of symmetric presentations to manipulate elements of large sporadic groups and to represent elements of these groups in much shorter forms than their corresponding permutation or matrix representation. Undertakes to develop a nested algorithm and a computer program to manipulate elements of large sporadic groups.

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19

Gros-Louis, François. "Genetics of familial and sporadic amyotrophic lateral sclerosis." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111859.

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Diseases affecting motor neurons, such as amyotrophic lateral sclerosis (Lou Gerhig's disease), hereditary spastic paraplegia and spinal bulbar muscular atrophy (Kennedy's disease) form a heterogeneous group of chronic progressive diseases and are among the most puzzling yet untreatable illnesses. Over the last decade identification of mutations in genes predisposing to these disorders has provided the means to better understand their pathogenesis. The discovery 13 years ago of SOD1 mutations linked to ALS, which account for less than 2% of all cases, had a major impact in the field. However,

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20

Sengupta, Neel. "Somatic copy number alterations in sporadic colorectal cancers." Thesis, Queen Mary, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538378.

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21

Wortham, Noel Christopher. "Functional genetics of hereditary and sporadic uterine leiomyomas." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445159/.

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Uterine leiomyomas (fibroids) are common benign neoplasms arising from the smooth muscle layer of the uterus, the myometrium. Despite their prevalence in reproductive age women, little is understood of their pathobiology. The work in this thesis examined genetic and functional factors involved in the aetiology of sporadic leiomyomas, those in the hereditary leiomyomatosis and renal cell cancer syndrome, and leiomyomas from patients of African/Afro-Caribbean ethnicity, who develop more severe tumours at an earlier age. Work was carried out studying: the role of apoptosis in the tumours mutation

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22

Cox, Rachel Mary. "On the origin of sporadic neutral sodium layers." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365136.

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23

Fraser, Judith Anne. "The BRCA1 gene product and sporadic breast cancers." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247765.

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Isolated in 1994, the <i>BRCA1</i> gene encodes a 1863 amino acid protein, the role of which remains undetermined. <i>BRCA1 </i>germ-line mutations, which result in loss of functional full-length protein, are associated with familial breast and ovarian cancer. This would suggest an important tumour suppressor role for the BRCA1 protein. No somatic mutations have been described in <i>BRCA1</i> in sporadic breast cancer cases. Defective transcription or post transcriptional modification of the BRCA1 protein may however precipitate the same outcome of a loss-of-function protein product facilitati

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24

Macarthur, Mairi. "Sporadic colorectal cancer : the role of chronic inflammation." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440593.

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In this thesis, an <i>in silico</i> investigation of available online microarray data found that normal colon, polyps and CRC have distinct gene expression patterns and that several key inflammation-related genes are up-regulated in polyps. This was also the findings of a pilot microarray study using Affymetrix human GeneChip<sup>®</sup> technology on normal colon and polyps biopsied from one individual. Validation of the microarray data for <i>IL-1B</i> and <i>il-8</i> was performed by RT-PCR and also revealed an overall up-regulation of these genes in polyp compared to normal colon. A CRC c

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25

Rannikmäe, Kristiina. "Genetic associations with sporadic cerebral small vessel disease." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23585.

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Background: Cerebral small vessel disease (SVD) causes substantial cognitive, psychiatric and physical disabilities. Despite its common nature, SVD pathogenesis and molecular mechanisms remain poorly understood, and prevention and treatment are probably suboptimal. Identifying the genetic determinants of SVD will improve understanding and may help identify novel treatment targets. The aim of this thesis is to better understand genetic associations with SVD through investigating its pathological, radiological and clinical phenotypes. Methods: To unravel the genetic associations with SVD, I used

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26

West, Nicholas J. "Studies in sporadic and familial colorectal adenomatous polyps." Thesis, St George's, University of London, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675935.

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Evidence exists to suggest that diets high in omega-3 fatty acids may be protective against the development of colorectal cancer with in vitro and pre-clinical models. Additionally, patients with a sporadic or genetic (eg familial adenomatous polyposis (FAP)) predisposition to developing colorectal adenomatous polyps exhibit altered cell kinetics in their colorectal mucosa as compared to normal subjects. The mam body of this thesis encompasses two clinical, randomised, placebo controlled trials. The first, EPA/POL/02 assessed whether subjects with a history of sporadic colorectal adenomata had

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27

Jacobi, Ch, and C. Arras. "6 hr tide seen in sporadic E layers." Universität Leipzig, 2018. https://ul.qucosa.de/id/qucosa%3A31768.

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The GPS radio occultation technique is used to study sporadic E (Es) layer plasma irregularities of the Earth’s ionosphere on a global scale using COSMIC/FORMOSAT-3 satellite constellation GPS signal-to-noise ratio (SNR) profiles. The maximum deviation from the mean SNR is attributed to the height of the Es layer. Es are produced by ion convergence due to vertical wind shear in the presence of a horizontal component of the Earth magnetic field, while the wind shear is provided mainly by solar tides. Indeed, close correlation between Es and wind shear phases have already been found for the semi

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28

Hope, Mairi E. "Sporadic colorectal cancer : role of the commensal microbiota." Thesis, University of Aberdeen, 2005. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU200894.

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There are vast numbers of bacteria present within the human colon and many studies have implicated these in CRC development. Despite this evidence, microbial diversity present at the mucosal surface has not been well characterised, with many investigations using culturing methods or extrapolating from analysis on faecal material. In this thesis, molecular analysis of colonic mucosal microbial diversity (caecum to rectum) in 10 healthy individuals revealed that each individual harboured their own microbial cohort that remained constant throughout the colon. Detailed 16S rDNA cloning and sequenc

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29

Liperovsky, V. A., O. A. Pochotelov, E. V. Liperovskaya, M. Parrot, C. V. Meister, and O. A. Alimov. "Modifications of sporadic E-layers caused by seismic activity." Universität Potsdam, 1998. http://opus.kobv.de/ubp/volltexte/2007/1479/.

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Contents: 1 Introduction 2 Formation and destruction of sporadic E-layers 3 Temporal variations of parameters of sporadic E-layers during earthquake preparation 3.1 Temporal variations of fbEs with time-scales of a few hours 3.2 Study of fbEs variations with characteristic time-scales of 0.5-3 hours 3.3 Variations of the parameters of sporadic E-layers with characteristic time-scales of 15-45 minutes 3.4 Sporadic E-layer variations with characteristic time-scales of 2-15 minutes 4 On the spatial scales of sporadic E-layer disturbances related to seismic activity 5 Complex experime

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30

Johnson, Suzanne Michelle. "Molecular analysis of sporadic breast cancer in younger women." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29385.

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This thesis presents molecular genetic evidence to support the hypothesis that sporadic breast carcinomas occurring in this younger age group are biologically different. 31 cases of infiltrating ductal carcinoma occurring in women aged 35 years were analysed for loss of heterozygosity and microsatellite instability at 10 polymorphic microsatellite markers in three key chromosomal intervals: 17p 13 (p53), 17q 11-21 (BRACA1 ) and 13q 12-13 (BRCA2). An elevated incidence of LOH was detected at BRCA1(65%) and BRCA2 (74%) when compared to a control group of matched postmenopausal cases (aged 55-72

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31

Macleod, Margaret-Ann. "The clinico-pathological phenotype of sporadic Creutzfeldt-Jakob disease." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/28507.

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Creutzfeldt-Jakob Disease (CJD) is a rare neurodegenerative disorder of the human central nervous system. It occurs in four main forms, defined essentially according to aetiology: sporadic, variant, iatrogenic and familial. All forms of the disease are characterised by the deposition of an abnormal cellular protein, the prion protein (PrP^sc), within the brain. Definitive diagnosis depends on identifying this along with other neuropathological changes such as spongiform degeneration and astrocytic gliosis. To date variant CJD has followed a relatively stereotyped clinical course with fairly co

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32

Young, Alison Claire. "Significance of VHL changes in sporadic renal cell carcinoma." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581867.

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The von Hippel-Lindau (VHL) tumour suppressor gene is central to the development of sporadic conventional clear cell renal cell carcinoma (ccRCC). The role VHL plays as part of a ubiquitin ligase targeting HIF-a for proteasomal degradation underpins many changes seen in ccRCC but the importance of other VHL functions and the clinical significance of specific genetic/epigenetic changes are not clear. Genetic and epigenetic analysis of VHL gene in 86 tumours from patients with ccRCC was carried out, adding to the 96 tumours already analysed in an ongoing study within the group. Overall, loss of

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33

Mistry, Sushilaben Harkisandas. "The role of p14ARF in familial and sporadic melanoma." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413193.

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34

Mitchell, Anna Louise. "Genomic analyses of familial and sporadic autoimmune Addison's disease." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2477.

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Autoimmune Addison’s disease (AAD) is a rare and highly heritable endocrinopathy. It is a complex genetic disease, meaning that it is due to a combination of interacting environmental and genetic factors. To date, the majority of the substantial genetic component to AAD aetiology remains undefined. In this study, a combination of hypothesis-driven (candidate gene) and discovery-driven (genome-wide) approaches have been used to search for novel genetic determinants of AAD. PCR-based approaches were undertaken to study the potential role of the CYP21A1P pseudogene in AAD. CYP21A1P is highly homo

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35

Whyman, Gavin John. "Sporadic breast cancer in young women : a microarray investigation." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29849.

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The aim of this thesis was to test the hypothesis that sporadic breast cancers in young women arise because of a profile of genetic alterations specific to that age group. Previous studies by our research group had identified a higher frequency of Loss of Heterozygosity (LOH) in the BRCA1, BRCA2 and p53 intervals in younger breast cancer cases (55 years); BRCA1 and P53 data had been related to protein expression. Investigations of BRCA2 protein and mRNA expression were inconclusive. A higher frequency of skewed X chromosome inactivation was identified in young women (55 years) with sporadic br

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36

Fytterer, Tilo, Christina Arras, and Christoph Jacobi. "Terdiurnal signatures in midlatitude sporadic E layers occurrence rates." Universität Leipzig, 2013. https://ul.qucosa.de/id/qucosa%3A16409.

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Global Positioning System radio occultation measurements by the FORMOsa SATellite mission-3/Constellation Observing System for Meteorology, Ionosphere and Climate satellites were used to analyse the behaviour of the signature of the terdiurnal tide in sporadic E (ES) layers at midlatitudes (43°N – 63°N). According to theory, the occurrence of ES is expected when the vertical zonal wind shear, which is mainly owing to solar tides, is negative. 4-year means, based on 3-monthly running mean zonal means from December 2006 - November 2010, were constructed for the terdiurnal oscillation in the occu

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37

McLaughlin, Heather Ward. "Modeling sporadic Alzheimer's disease using induced pluripotent stem cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13094355.

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Despite being the leading cause of neurodegeneration and dementia in the aging brain, the cause of Alzheimer's disease (AD) remains unknown in most patients. The terminal pathological hallmarks of abnormal protein aggregation and neuronal cell death are well-known from the post-mortem brain tissue of Alzheimer's disease patients, but research into the earliest stages of disease development is hindered by limited model systems. In this thesis, an in vitro human neuronal system was derived from induced pluripotent stem (iPS) cell lines reprogrammed from dermal fibroblasts of AD patients and ag

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38

Nishijo, Koichi. "Mutation analysis of the RECQL4 gene in sporadic osteosarcomas." Kyoto University, 2005. http://hdl.handle.net/2433/144775.

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39

Lee, James Hoi-Fung. "Muscle and Nerve Excitability in Sporadic Inclusion Body Myositis." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/22896.

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Sporadic inclusion body myositis (sIBM) is the most common acquired myopathy of older adults in the developed world, but its pathophysiology remains poorly understood with both degenerative and inflammatory mechanisms thought to play a role. It is a slowly, but relentlessly progressive disease that often evades early diagnosis and remains without effective disease modifying treatment, disabling sufferers with progressive limb weakness and dysphagia. Diagnosis remains difficult, with consensus criteria relying on a combination of histopathological, clinical and biochemical features for disease

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40

PANZA, ANNA. "Identification of fusion genes associated with sporadic colorectal carcinogenesis." Doctoral thesis, Università di Foggia, 2018. http://hdl.handle.net/11369/369487.

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41

Catalán, García Marc. "Mitochondrial profile and amyloidogenic molecules in sporadic inclusion body myositis." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/586382.

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Sporadic inclusion body myositis (sIBM) is the most common myopathy in elderly. This disease causes muscle wasting with both distal and proximal affectation. Quadriceps and finger flexors are muscle typically affected. At pathological level, three different features are present in muscle biopsies: inflammation, mitochondrial abnormalities and degeneration. The presence of T-cell infiltrate, ragged-red fibers and rimmed vacuoles are some features linked to these pathological processes. Protein misfolding and aggregation lead to the formation of the mentioned rimmed vacuoles, composed by many di

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Rylah, Paul J. "Observations of Sporadic-E utilising high frequency oblique sounding techniques." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/30615.

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Sporadic-E is an 'abnormal', altitude-confined intensification of the E-region plasma density. Its presence may both enable and disable an oblique propagation circuit, depending on the prevalent propagation path geometry, the ambient ionospheric conditions, and the plasma structure of the layer itself. This thesis studies the plasma characteristics of sub-auroral sporadic-E layers, utilising oblique HF 'Chirp' sounders, deployed during times of both quiet and disturbed geomagnetic activity. During largely quiet geomagnetic conditions, a relationship is established between the sporadic-E top fr

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de, Foy K. "Analysis of candidate tumour suppressor genes in sporadic ovarian tumours." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598448.

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The aim of this thesis was to identify genes which are important in the initiation and/or progression of sporadic ovarian cancer. A series of ovarian teratomas and carcinomas was collected and three candidate tumour suppressor genes were analysed. The c-<I>mos</I> gene is an ovarian teratoma susceptibility gene in mice; its absence causes the growth of these tumours. Twenty human ovarian teratomas were collected and the coding region of the c-<I>mos</I> gene was analysed for somatic and germline mutations. No disease-causing alterations were found. Germline mutations of the BRCA2 gene predispo

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44

Distler, Marius, Daniela E. Aust, Jürgen Weitz, Christian Pilarsky, and Robert Grützmann. "Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-147337.

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Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic ca

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45

Ahmed, M. "Investigating novel therapeutic approaches for sporadic inclusion body myositis (sIBM)." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1343623/.

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Sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease affecting adults over the age of 50. Although the aetiology of this disease remains unclear, there is evidence for both inflammatory and myodegenerative processes in sIBM muscle pathology. In particular, abnormal protein aggregation is characteristic of affected muscle, with inclusion bodies incorporating amyloid-beta precursor protein (β-APP) among many others. Therapeutic interventions tested to date for sIBM have targeted the immune system; but none have been beneficial and sIBM currently remains untreatable.

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Messori, Gabriele. "The sporadic nature of meridional heat transport in the atmosphere." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/22158.

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The present study analyses meridional atmospheric heat transport, due to transient eddies, in the European Centre for Medium-Range Weather Forecasts ERA-Interim reanalysis data. Probability density functions of the transport highlight the dominant role played by extreme events. In both hemispheres, events in the top 5 percentiles typically account for over half of the net poleward transport. As a result of this sensitivity to extremes, a large fraction of the heat transport by transient eddies, at a given location and season, is realised through randomly spaced bursts (a few per season), rathe

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47

Miller, A. D. "Development of new therapeutic strategies for sporadic Inclusion Body Myositis." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469260/.

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Sporadic inclusion body myositis (IBM) is the commonest myopathy acquired after 50 years of age and causes significant disability. No effective treatment exists despite several clinical trials of immunotherapies. This reflects a lack of pre-clinical disease models. The work described in this thesis began with development of such a system, in which disease relevant pathological outcome measures were characterised in vitro using primary satellite cell cultures. Through over-expression of β-Amyloid Precursor Protein or exposure to inflammatory mediators IL1β and TNFα, IBM-like pathology was induc

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48

Wright, Benjamin. "Graphs associated with the sporadic simple groups Fi₂₄ and BM." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/graphs-associated-with-the-sporadic-simple-groups-fi24-and-bm(dcdd493b-929d-4f91-a6bc-48c6b5fda3ba).html.

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Our aim is to calculate some graphs associated with two of the larger sporadicsimple groups, Fi₂₄ and the Baby Monster. Firstly we calculate the point line collinearity graph for a maximal 2-local geometry of Fi₂₄. If T is such a geometry, then the point line collinearity graph G will be the graph whose vertices are the points in T, with any two vertices joined by an edge if and only if they are incident with a common line. We found that the graph has diameter 5 and we give its collapsed adjacency matrix. We also calculate part of the commuting involution graph, C, for the class 2C of the Baby

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Rice, Judd Christopher. "Epigenetic silencing of BRCA1 and maspin in sporadic breast cancer." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289142.

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The RNA expression of the tumor suppressor genes BRCA1 and maspin are frequently decreased or lost in sporadic breast cancer. We hypothesized that inactivation of these genes was due to aberrant epigenetic silencing at the level of gene transcription. In this study we show that aberrant cytosine methylation of the BRCA1 and maspin CpG island promoters is a common event in the inactivation of these genes in sporadic breast cancer cell lines. Furthermore, we show that the methylation-associated inactivation of BRCA1 occurs in 15-30% of sporadic breast cancer patient specimens and our data sugges

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Eusebi, Leonardo Henry Umberto <1979&gt. "Clinicopathological and molecular features of sporadic early onset colorectal cancers." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7300/1/Eusebi_Leonardo_Tesi.pdf.

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The increasing occurrence of CRC developing in young patients with no identified genetic predisposition, defined as sporadic early onset colorectal cancers (EOCRCs), demands maintaining a high index of suspicion when people below 50 years of age present with symptoms. To define the clinicopathological features and the stage at presentation of EOCRCs, as well as to understand whether the histological, immunohistochemical and molecular analyses were associated with particular clinicopathological parameters and oncologic outcome, a total of 94 cases of EOCRCs diagnoses between 2006 and 2014 at

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