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Academic literature on the topic 'SPIRAL PASSIVE MICROMIXER'

Author: Grafiati
Published: 11 September 2023

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Journal articles on the topic "SPIRAL PASSIVE MICROMIXER"

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Rouhi, Omid, Sajad Razavi Bazaz, Hamid Niazmand, Fateme Mirakhorli, Sima Mas-hafi, Hoseyn A. Amiri, Morteza Miansari, and Majid Ebrahimi Warkiani. "Numerical and Experimental Study of Cross-Sectional Effects on the Mixing Performance of the Spiral Microfluidics." Micromachines 12, no. 12 (November 29, 2021): 1470. http://dx.doi.org/10.3390/mi12121470.

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Mixing at the microscale is of great importance for various applications ranging from biological and chemical synthesis to drug delivery. Among the numerous types of micromixers that have been developed, planar passive spiral micromixers have gained considerable interest due to their ease of fabrication and integration into complex miniaturized systems. However, less attention has been paid to non-planar spiral micromixers with various cross-sections and the effects of these cross-sections on the total performance of the micromixer. Here, mixing performance in a spiral micromixer with different channel cross-sections is evaluated experimentally and numerically in the Re range of 0.001 to 50. The accuracy of the 3D-finite element model was first verified at different flow rates by tracking the mixing index across the loops, which were directly proportional to the spiral radius and were hence also proportional to the Dean flow. It is shown that higher flow rates induce stronger vortices compared to lower flow rates; thus, fewer loops are required for efficient mixing. The numerical study revealed that a large-angle outward trapezoidal cross-section provides the highest mixing performance, reaching efficiencies of up to 95%. Moreover, the velocity/vorticity along the channel length was analyzed and discussed to evaluate channel mixing performance. A relatively low pressure drop (<130 kPa) makes these passive spiral micromixers ideal candidates for various lab-on-chip applications.
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Yang, Shuang, He Zhang, Shuihua Yang, Yunlong Zheng, Jianan Wang, and Rongyan Chuai. "Performance Investigation of Micromixer with Spiral Pattern on the Cylindrical Chamber Side Wall." Micromachines 14, no. 7 (June 25, 2023): 1303. http://dx.doi.org/10.3390/mi14071303.

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In this paper, a sequence of passive micromixers with spiral patterns on the side wall of cylindrical chambers are designed, optimized, prepared and tested. The simulation studies show that the vortex magnitude and continuity in the mixing chamber are the most important factors to determine mixing performance, while the inlet position and structural parameters are secondary influences on their performance. According to the above principles, the performance of a micromixer with a continuous sidewall spiral finally wins out. The total mixing length is only 14 mm, but when Re = 5, the mixing index can reach 99.81%. The multi-view visual tests of these mixer chips prepared by 3D printing are consistent with the simulation results. This paper provides a new idea for optimizing the micromixer with spiral patterns on the side wall and the problems of floor area and pressure loss are significantly improved compared to the conventional spiral structure.
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ZHANG, SHUAI, XUEYE CHEN, ZHONGLI WU, and YUE ZHENG. "NUMERICAL STUDY ON KOCH FRACTAL BAFFLE MICROMIXER." Fractals 27, no. 03 (May 2019): 1950026. http://dx.doi.org/10.1142/s0218348x19500269.

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This paper is mainly to study the application of Koch fractal baffle to passive micromixers. It can be determined that the mixing efficiency of secondary Koch fractal baffle (SKFB) micromixer is better than that of primary Koch fractal baffle (PKFB). We compare and analyze the mixing efficiency when the angle between the baffle and the microchannel is [Formula: see text], [Formula: see text] and [Formula: see text] with the height 100[Formula: see text][Formula: see text]m. With the changing of the angle, it contributes to enhance the chaotic convection of the micromixer. Especially at the angle of [Formula: see text], the vortex caused by the Koch fractal baffle structure is more obvious, the mixing efficiency of micromixer is more than 95% at Re [Formula: see text] 0.05 and 100. When the height of Koch fractal baffle is 50, 75 and [Formula: see text]m, the mixing efficiency of the micromixer gradually increases. The whirling and spiral phenomenon of the streamlines increases the chaotic convection and promotes the improvement of the mixing efficiency. In the direction of microchannel, nine sections which have a significant effect on the mixing efficiency are investigated. The encircling and split phenomenon affected by the chaotic convection is shown in nine sections at Re [Formula: see text] 0.05, 10 and 100.
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Wu, Chih-Wei, Ting-I. Wu, Wei-Han Chen, and Long-Sun Huang. "DESIGN, FABRICATION, AND TEST OF A SILICATE MICROSENSOR." Biomedical Engineering: Applications, Basis and Communications 21, no. 06 (December 2009): 389–94. http://dx.doi.org/10.4015/s1016237209001519.

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This work describes a portable microsensor for analyzing the silicate concentration in water. Conventionally adopted silicate analysis methods involve bulky instrumentation that are limited in portability and immediateness. The proposed silicate microsensor consists of a microliquid core waveguide, passive spiral micromixer, and bubble traps that possess excellent signal enhancement properties. The microsensor size is 52 × 26 mm, while each measurement requires only 115 μl of a sample and reagents, thereby reducing the sample requirement for a considerable amount of time and work to collect expensive reagents. The spiral micromixer has a mixing capability superior to that of a premix mixture. Bubble traps have been developed to trap air bubbles formed in the microchannel in order to prevent gas bubbles from interfering with the measurements. As a linear function of silicate concentration, the absorbance response ranges from 0 to 250 nM. Additionally, the linearity is excellent with a linear R value of 0.9985 and the experimental detection limit is 8.9 nM. The proposed portable microsensor significantly contributes to aqueous inspection, subsequently creating a highly value-added technology for chemical sensors and microsystems.
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Jain, Shubha, Sarpras Swain, Lopamudra Das, Sarita Swain, Lopamudra Giri, Anand Kumar Kondapi, and Harikrishnan Narayanan Unni. "Microfluidic Protein Imaging Platform: Study of Tau Protein Aggregation and Alzheimer’s Drug Response." Bioengineering 7, no. 4 (December 13, 2020): 162. http://dx.doi.org/10.3390/bioengineering7040162.

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Tau protein aggregation is identified as one of the key phenomena associated with the onset and progression of Alzheimer’s disease. In the present study, we performed on-chip confocal imaging of tau protein aggregation and tau–drug interactions using a spiral-shaped passive micromixing platform. Numerical simulations and experiments were performed in order to validate the performance of the micromixer design. We performed molecular modeling of adenosine triphosphate (ATP)-induced tau aggregation in order to successfully validate the concept of helical tau filament formation. Tau aggregation and native tau restoration were realized using an immunofluorescence antibody assay. The dose–response behavior of an Alzheimer’s drug, methylthioninium chloride (MTC), was monitored on-chip for defining the optimum concentration of the drug. The proposed device was tested for reliability and repeatability of on-chip tau imaging. The amount of the tau protein sample used in our experiments was significantly less than the usage for conventional techniques, and the whole protein–drug assay was realized in less than two hours. We identified that intensity-based tau imaging could be used to study Alzheimer’s drug response. In addition, it was demonstrated that cell-free, microfluidic tau protein assays could be used as potential on-chip drug evaluation tools for Alzheimer’s disease.
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Tokas, Sulekh, Mohammad Zunaid, and Mubashshir Ahmad Ansari. "Non-Newtonian fluid mixing in a Three-Dimensional spiral passive micromixer." Materials Today: Proceedings, April 2021. http://dx.doi.org/10.1016/j.matpr.2021.03.656.

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Dissertations / Theses on the topic "SPIRAL PASSIVE MICROMIXER"

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JAVED, SYED FARHAN. "NUMERICAL ANALYSIS OF MIXING PERFORMANCE IN A SPIRAL PASSIVE MICROMIXER." Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18051.

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This research work possesses a mathematical analysis and contrasting of mixing characteristic and flow behavior inside microchannels with different geometries: Simple T shape and Spiral/Helical shape (with and without nanofluid). Micromixing has become very popular and useful contemporarily. The flow analysis is carried out using Navier-Stokes equations and mixing performance of two fluids, namely; water and dye is numerically calculated. The dye is infused with 1% Al2O3 in the case of a spiral T shape micromixer with nanofluid. The boundary conditions are specified in terms of suitable velocity at the two inlets and the pressure is set as zero static at the micromixer outlet. The mixing performance is calculated concerning mixing index or efficiency of mixing. The spiral T shape mixer creates the vortices and makes the swirling flows even at low Reynolds numbers in comparison to a basic T shape mixer. The circular cross-section at the beginning of mixing spiral microchannel enhances the contact surface area of the fluid by widening the flow. The proposed spiral microchannel is found to be efficient in mixing fluids at a vast range of Reynolds numbers. The three micromixers are observed, analyzed and their mixing index is finally observed at different Reynolds number, namely 5, 45, 165, and 350. This suggested mixer is easy to design and fabricate and provides a wide control for the mixing index based on Reynolds number. The results possess that the mixing in a spiral microchannel is very subtle to the input variables, exhibiting different characteristics at different Reynolds numbers. This research is helpful in the biomedical and biochemical sciences, and their applications in fields such as cell storage, screening, cancer detection techniques, DNA analysis, dynamic cell separators, etc.
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Book chapters on the topic "SPIRAL PASSIVE MICROMIXER"

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Javed, Syed Farhan, Mohammad Zunaid, and Mubashshir Ahmad Ansari. "Mathematical Analysis of a Spiral Passive Micromixer." In Lecture Notes in Mechanical Engineering, 805–12. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-9678-0_67.

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