Log in

Relevant bibliographies by topics / Spindle and C-axis drives / Journal articles

To see the other types of publications on this topic, follow the link: Spindle and C-axis drives.

Journal articles on the topic 'Spindle and C-axis drives'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Spindle and C-axis drives.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Chen, Shao Hsien, Chin Mou Hsu, Kuo Lin Chiu, and Chu Peng Chan. "Research on High Performance Direct-Driving Motor Applied to Swivel Spindle Head." Applied Mechanics and Materials 701-702 (December 2014): 874–78. http://dx.doi.org/10.4028/www.scientific.net/amm.701-702.874.

Full text

Abstract:

Swivel spindle head is a key component used in five-axis machine tool of high performance and is of great importance in application and design. Nowadays, more and more components are manufactured by high performance multi-axis CNC machine tools, such as components of spaceflight, renewable energy and automobile, etc. Therefore, high performance machine tools of multiple axes are more and more urgently demanded, while Swivel spindle head is one of the most important components for a multi-axis machine tool. Hence, Swivel spindle head is one of the key to developers multi-axis machine tool . The

APA, Harvard, Vancouver, ISO, and other styles

2

Chen, Shao Hsien, Chin Mou Hsu, Kuo Lin Chiu, and Chu Peng Chan. "The Impact of Different Direct-Driving Motor Design on Swivel Spindle Head." Applied Mechanics and Materials 789-790 (September 2015): 791–94. http://dx.doi.org/10.4028/www.scientific.net/amm.789-790.791.

Full text

Abstract:

Swivel spindle head is a key component used in gantry type five-axis machine tool of high performance and is of great importance in its application and design. Nowadays, more and more components are manufactured by high precision CNC machine tools, such as components of spaceflight, renewable energy and automobile, etc. Therefore, high precision machine tools of multiple axes are more and more urgently demanded, while dual axis rotary head is one of the most important components for a multi-axis machine tool. Hence, it will be a key to develop dual axis spindle head that meets high precision n

APA, Harvard, Vancouver, ISO, and other styles

3

Mikhov, Mikho, and Marin Zhilevski. "Study and Performance Improvement of the Drive Systems for a Class of Machine Tools." MATEC Web of Conferences 299 (2019): 05003. http://dx.doi.org/10.1051/matecconf/201929905003.

Full text

Abstract:

This paper deals with some problems in the modernization of a type of machine tools with multi–coordinate drive systems. The basic requirements to the drives of each coordinate axis and the spindle are presented. Using the analysis carried out, a practical approach to appropriate selection of the respective drives is applied. The methodology offered is illustrated with some examples for choice of drives with direct current and alternating current motors. Some experimental research of cases with different feed and spindle drives are described and discussed. Better capabilities of the modernized

APA, Harvard, Vancouver, ISO, and other styles

4

Ishizaki, Kosuke, Burak Sencer, and Eiji Shamoto. "Cross Coupling Controller for Accurate Motion Synchronization of Dual Servo Systems." International Journal of Automation Technology 7, no. 5 (2013): 514–22. http://dx.doi.org/10.20965/ijat.2013.p0514.

Full text

Abstract:

In order to attain higher manufacturing efficiency, “dual” (two) servo systems are widely used in advanced Computer Numerical Controlled (CNC) machine tools. A well-known example is the linear motor driven gantry type of micro machine tools where dual servos are employed to drive the heavier gantry axis. Recently, dual servos are also used in spindle systems. “Double sided milling” is an example where two spindles are required to cooperatively remove material on both sides of a workpiece. Synchronization of dual servo systems is crucial for achieving the desired manufacturing accuracy. This pa

APA, Harvard, Vancouver, ISO, and other styles

5

Rakhmanov, S. R. "Elaboration of a lubrication system for universal spindle hinges of rolling mills." Ferrous Metallurgy. Bulletin of Scientific , Technical and Economic Information 77, no. 9 (2021): 1047–53. http://dx.doi.org/10.32339/0135-5910-2021-9-1047-1053.

Full text

Abstract:

The experience of running drives of most of heavy-duty rolling mills shows that the designs of universal spindles with blade hinges under conditions of increased alternating loads are most acceptable comparing with other spindles types. Open friction surfaces are the drawbacks of these types of spindles, which complicate the matter of continuous supply of lubrication. Perfected effective system of forced lubrication of rolling mill spindles hinges proposed. The facility for their lubrication has a bearing support of balancing design, spindle, in radial holes of which spring-loaded plungers are

APA, Harvard, Vancouver, ISO, and other styles

6

Li, Wenzhe, Helena A. Crellin, Dhanya Cheerambathur, and Francis J. McNally. "Redundant microtubule crosslinkers prevent meiotic spindle bending to ensure diploid offspring in C. elegans." PLOS Genetics 19, no. 12 (2023): e1011090. http://dx.doi.org/10.1371/journal.pgen.1011090.

Full text

Abstract:

Oocyte meiotic spindles mediate the expulsion of ¾ of the genome into polar bodies to generate diploid zygotes in nearly all animal species. Failures in this process result in aneuploid or polyploid offspring that are typically inviable. Accurate meiotic chromosome segregation and polar body extrusion require the spindle to elongate while maintaining its structural integrity. Previous studies have implicated three hypothetical activities during this process, including microtubule crosslinking, microtubule sliding and microtubule polymerization. However, how these activities regulate spindle ri

APA, Harvard, Vancouver, ISO, and other styles

7

Nunes, Vanessa, Margarida Dantas, Domingos Castro, et al. "Centrosome–nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity." Molecular Biology of the Cell 31, no. 16 (2020): 1675–90. http://dx.doi.org/10.1091/mbc.e20-01-0047.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Maurya, Swami Nath, Kun-Ying Li, Win-Jet Luo, and Shih-Ying Kao. "Effect of Coolant Temperature on the Thermal Compensation of a Machine Tool." Machines 10, no. 12 (2022): 1201. http://dx.doi.org/10.3390/machines10121201.

Full text

Abstract:

Machine tool (MT) accuracy is an important factor in the industry and is affected by heat generation through internal and external moving parts; the electrical components used; and variable environmental temperatures. Thermal errors lead to 40–60% of all MT errors. To improve MT accuracy, efficient techniques to minimize thermal errors must be identified. This study investigated the coolant temperature effects under different rotating speeds of a standalone built-in spindle system and computer numerical control (CNC) machine with a direct-drive spindle on the accuracy of thermal deformation pr

APA, Harvard, Vancouver, ISO, and other styles

9

Wilck, Ines, Andreas Wirtz, Torben Merhofe, Dirk Biermann, and Petra Wiederkehr. "Minimisation of Pose-Dependent Regenerative Vibrations for 5-Axis Milling Operations." Journal of Manufacturing and Materials Processing 5, no. 3 (2021): 99. http://dx.doi.org/10.3390/jmmp5030099.

Full text

Abstract:

The machining of free-formed surfaces, e.g., dies or moulds, is often affected by tool vibrations, which can affect the quality of the workpiece surface. Furthermore, in 5-axis milling, the dynamic properties of the system consisting of the tool, spindle and machine tool can vary depending on the tool pose. In this paper, a simulation-based methodology for optimising the tool orientation, i.e., tilt and lead angle of simultaneous 5-axis milling processes, is presented. For this purpose, a path finding algorithm was used to identify process configurations, that minimise tool vibrations based on

APA, Harvard, Vancouver, ISO, and other styles

10

Křepela, J., and Vladislav Singule. "Simulation of the Dynamic Behaviors of the C Axis Drive by the Turning Center." Solid State Phenomena 147-149 (January 2009): 356–61. http://dx.doi.org/10.4028/www.scientific.net/ssp.147-149.356.

Full text

Abstract:

The paper describes the mathematical model for C axis of the multifunction turning center with worm gear. Talks about the mathematical model with multi-body mass dynamic system. The drive works in the positional feedback and his mathematical model is specified for detection of the dynamical behaviors of the C axis. The turning center is designed for a heavy roughing forged piece from high carbon steels by the power of main motor 71kW. The C axis must be designed as accurate angle position axis and with big dynamic stability of regulation by step or pulse loading. The C axis drive is constructe

APA, Harvard, Vancouver, ISO, and other styles

11

Wu, Dong Xu, Guo Li, Bo Wang, Zheng Qiao, and Lei Lv. "Fabrication of Microstructured Surfaces by Five-Axis Ultra Precision Machine Tool." Key Engineering Materials 625 (August 2014): 187–91. http://dx.doi.org/10.4028/www.scientific.net/kem.625.187.

Full text

Abstract:

In this paper, a five-axis ultra precision machine tool for fabrication of microstructured surfaces is presented. This machine consists of two rotary axes (C&B) and three linear axes (X&Y&Z). High precision aerostatic bearing and torque motor are adopted in C axis (main spindle) and B axis. X axis and Z axis use the hydrostatic guideway and are driven by linear motors. Y axis is driven by torque motor and precision ball screw. This machine is able to realize multiple processing methods, including ultra precision diamond turning, ultra precision milling, fly-cutting, fast tool servo

APA, Harvard, Vancouver, ISO, and other styles

12

Merk, Daniel J., Pengcheng Zhou, Samuel M. Cohen, et al. "The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors." Developmental Neuroscience 42, no. 5-6 (2020): 170–86. http://dx.doi.org/10.1159/000512976.

Full text

Abstract:

During neural development, stem and precursor cells can divide either symmetrically or asymmetrically. The transition between symmetric and asymmetric cell divisions is a major determinant of precursor cell expansion and neural differentiation, but the underlying mechanisms that regulate this transition are not well understood. Here, we identify the Sonic hedgehog (Shh) pathway as a critical determinant regulating the mode of division of cerebellar granule cell precursors (GCPs). Using partial gain and loss of function mutations within the Shh pathway, we show that pathway activation determine

APA, Harvard, Vancouver, ISO, and other styles

13

Chen, En Ping, Shao Hui Li, Feng He Wu, and Chong Min Jiang. "Structure Design of Biaxial Rotary Milling Head with High-Torque, High-Precision and Mechanical Spindle." Key Engineering Materials 621 (August 2014): 337–45. http://dx.doi.org/10.4028/www.scientific.net/kem.621.337.

Full text

Abstract:

As a key component of heavy five-axis linkage CNC machine tools, the existing mechanical biaxial rotary milling heads are usually driven by worm gear, timing belt, or multi-stage gears. Worm gear is inefficiency to transmit motion, hard to maintain the accuracy and difficult to eliminate all clearance; Timing belt can be seriously worn and cannot maintain good accuracy; and multi-stage gears transmission has defects such as long chain, low transmission stiffness. This paper aims at designing a biaxial rotary milling head with large output torque of 3000Nm, high precision and high rigidity. So

APA, Harvard, Vancouver, ISO, and other styles

14

Hadjisavva, Rania, and Paris A. Skourides. "Spindle Orientation Regulation Is Governed by Redundant Cortical Mechanosensing and Shape-Sensing Mechanisms." International Journal of Molecular Sciences 26, no. 12 (2025): 5730. https://doi.org/10.3390/ijms26125730.

Full text

Abstract:

Spindle orientation (SO) plays a critical role in tissue morphogenesis, homeostasis, and tumorigenesis by ensuring accurate division plane positioning in response to intrinsic and extrinsic cues. While SO has been extensively linked to cell shape sensing and cortical forces, the interplay between shape- and force-sensing mechanisms remains poorly understood. Here, we reveal that SO is governed by two parallel mechanisms that ensure redundancy and adaptability in diverse cellular environments. Using live-cell imaging of cultured cells, we demonstrate that the long prometaphase axis (LPA) is a s

APA, Harvard, Vancouver, ISO, and other styles

15

Aquino, Alma P., Wenzhe Li, Aastha Lele, et al. "Inward transport of organelles drives outward migration of the spindle during C. elegans meiosis." Cell Reports 44, no. 4 (2025): 115458. https://doi.org/10.1016/j.celrep.2025.115458.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Choirony, Iklil Vurqon, Mohammad Slamed Hariyanto, Miftachul Ulum, Achmad Ubaidillah, Haryanto Haryanto, and Riza Alfita. "Rancang Bangun Acrylic Engraver and Cutting Machine Menggunakan CNC Milling 3 Axis Berbasis Mikrokontroler." Elektrika 13, no. 1 (2021): 13. http://dx.doi.org/10.26623/elektrika.v13i1.3071.

Full text

Abstract:

<p><em><span lang="EN-US">The purpose of this research is to design and implement an automatic acrylic carving and cutting tool using a microcontroller-based 3-axis CNC machine. Computer Numerical Control (CNC) is a machine technology that is operated automatically to support the demand for a product that has a complex shape and high accuracy. In general, the construction of a 3-axis CNC machine and its working system is synchronization between the computer and its mechanics. This tool has a work process by utilizing the G-Code method as a command on the machine to carry out

APA, Harvard, Vancouver, ISO, and other styles

17

Sablin, Pavel, Alexander Kosmynin, and Vladimir Shchetinin. "Controlled spindle supports as a tool for ensuring machining quality." Proceedings of Irkutsk State Technical University 24, no. 5 (2020): 1019–29. http://dx.doi.org/10.21285/1814-3520-2020-5-1019-1029.

Full text

Abstract:

The purpose of the work is to provide conditions for machined workpiece surface quality control based on the use of gas-magnetic supports in machine-tool systems (on example of the 3K227A internal grinding machine). To model the trajectory of tool and workpiece mutual movement the methods of nonlinear dynamics are used. The literature data on the problem are analyzed and experimental studies are carried out. Based on the considered issues of controlling the dynamic stability of technological systems under machining by means of contactless controlled gas-magnetic supports of spindle units, a sc

APA, Harvard, Vancouver, ISO, and other styles

18

Hrytsai, Ihor, and Dmytro Herus. "STUDY OF THE GEAR CUTTING PROCESS BY THE RADIAL-CIRCULAR METHOD." Ukrainian Journal of Mechanical Engineering and Materials Science 9, no. 4 (2023): 20–26. http://dx.doi.org/10.23939/ujmems2023.04.020.

Full text

Abstract:

The results of the study of the radial-circular method of gear cutting are presented. The cutting and shaping of teeth is carried out by a thin disc cutter under conditions of continuous generating, with a combination of axial feed of the cutter and its constructive radial movement due to eccentric installation on the spindle axis. The value of the eccentricity is determined by the gear module. A graph-analytical model was used to calculate the parameters of the cuts, and the cutting force and torque on the cutter axis were modeled using these data. It was found that the cutting process is cha

APA, Harvard, Vancouver, ISO, and other styles

19

Kondo, Kazuki, and Shin-Ichi Tooe. "Measurement of the Tangential Grinding Force Using the Slip of an Induction Motor—Construction of the Measurement System." Advanced Materials Research 76-78 (June 2009): 107–12. http://dx.doi.org/10.4028/www.scientific.net/amr.76-78.107.

Full text

Abstract:

A new system for measuring a tangential grinding force using the slip of the rotational speed of an induction motor was developed. The motor slip is measured as the change in the rotational period for the induction motor. The system operates LabVIEW software on a personal computer, and a rotary encoder is connected with the motor spindle, which drives the axis of a grinding wheel. A signal of one pulse per rotation from the rotary encoder is input to the interface of the computer to measure the rotational period. LabVIEW has the flexibility of a programming language and operates within a graph

APA, Harvard, Vancouver, ISO, and other styles

20

R., Deepthi, Vidya K., Yamini S., and VVS Haranadh Prasad Dr. "Expert System for Spindle Design." International Journal of Innovative Science and Research Technology (IJISRT) 9, no. 11 (2025): 3377–78. https://doi.org/10.5281/zenodo.14613809.

Full text

Abstract:

In machine tools, spindle refers to that rotating axis of the machine. The machine tool spindle is considered the most important mechanical part of the metal removal process associated with machining operations. Flexible spindles give rise to unstable chatter vibrations. Modern spindles are made using the fundamental principles of metal-cutting dynamics and machine design. The expert spindle design system technique presented in this study is founded on the effective use of design expertise, machine design laws, and metal cutting dynamics. By determining the work material, the ideal cutting con

APA, Harvard, Vancouver, ISO, and other styles

21

Lázaro-Diéguez, Francisco, Iaroslav Ispolatov, and Anne Müsch. "Cell shape impacts on the positioning of the mitotic spindle with respect to the substratum." Molecular Biology of the Cell 26, no. 7 (2015): 1286–95. http://dx.doi.org/10.1091/mbc.e14-08-1330.

Full text

Abstract:

All known mechanisms of mitotic spindle orientation rely on astral microtubules. We report that even in the absence of astral microtubules, metaphase spindles in MDCK and HeLa cells are not randomly positioned along their x-z dimension, but preferentially adopt shallow β angles between spindle pole axis and substratum. The nonrandom spindle positioning is due to constraints imposed by the cell cortex in flat cells that drive spindles that are longer and/or wider than the cell's height into a tilted, quasidiagonal x-z position. In rounder cells, which are taller, fewer cortical constraints make

APA, Harvard, Vancouver, ISO, and other styles

22

Hamamoto, Karina, Julia Lesperance, Huacheng Luo, et al. "Myeloid Master Regulators PU.1 and CEBPA Suppress Leukemogenesis through Downregulating Cell Cycle Related Genes in NPM1 Mutated Leukemia." Blood 142, Supplement 1 (2023): 5690. http://dx.doi.org/10.1182/blood-2023-189988.

Full text

Abstract:

Nucleophosmin1 mutation (NPM1c) is the most common mutation in adult acute myeloid leukemia (AML) and known as a driver mutation causing leukemogenesis through upregulating homeotic gene transcription. Mutated NPM1 is reported to mis-localize in the cytoplasm. However, how cytoplasmic NPM1c regulates leukemic transcription remains poorly understood. We previously reported that NPM1c reprograms homeotic and leukemogenic transcription through reshaping CTCF-defined three-dimensional topology associated domain (TAD). Also, re-localization of cytoplasmic NPM1c to the nucleus switches MIZ1/MYC repr

APA, Harvard, Vancouver, ISO, and other styles

23

Kenchappa, Rajappa, Athanassios Dovas, Michael Argenziano, et al. "DDDR-28. EGFR AND SRC-MEDIATED ACTIVATION OF STAT3 DRIVES RESISTANCE TO MITOTIC INHIBITORS IN GLIOBLASTOMA, AND CAN BE REVERSED WITH FDA-APPROVED DRUGS." Neuro-Oncology 24, Supplement_7 (2022): vii105. http://dx.doi.org/10.1093/neuonc/noac209.393.

Full text

Abstract:

Abstract While the allure of targeted therapies in oncology has been their high degree of specificity and potency for key tumor drivers, they have been disappointing in glioblastoma (GBM), even for drugs that are blood brain barrier permeable and CNS retained. This point is highlighted by the experience with mitotic spindle inhibitors, drugs which block the G2M transition and induce mitotic catastrophe—a phenotype characterized by cell enlargement and polyploidy that leads to apoptotic cell death. We have shown that one of these, a potent inhibitor of the mitotic kinesin Kif11 (ispinesib), is

APA, Harvard, Vancouver, ISO, and other styles

24

Gönczy, Pierre, Silke Pichler, Matthew Kirkham, and Anthony A. Hyman. "Cytoplasmic Dynein Is Required for Distinct Aspects of Mtoc Positioning, Including Centrosome Separation, in the One Cell Stage Caenorhabditis elegans Embryo." Journal of Cell Biology 147, no. 1 (1999): 135–50. http://dx.doi.org/10.1083/jcb.147.1.135.

Full text

Abstract:

We have investigated the role of cytoplasmic dynein in microtubule organizing center (MTOC) positioning using RNA-mediated interference (RNAi) in Caenorhabditis elegans to deplete the product of the dynein heavy chain gene dhc-1. Analysis with time-lapse differential interference contrast microscopy and indirect immunofluorescence revealed that pronuclear migration and centrosome separation failed in one cell stage dhc-1 (RNAi) embryos. These phenotypes were also observed when the dynactin components p50/dynamitin or p150Glued were depleted with RNAi. Moreover, in 15% of dhc-1 (RNAi) embryos,

APA, Harvard, Vancouver, ISO, and other styles

25

Schnerch, Dominik, Julia Felthaus, Lara Mentlein, Monika Engelhardt, and Ralph M. Waesch. "Analysis of Mitosis In Acute Myeloid Leukemia Using Live-Cell Imaging." Blood 116, no. 21 (2010): 3363. http://dx.doi.org/10.1182/blood.v116.21.3363.3363.

Full text

Abstract:

Abstract Abstract 3363 Proper mitotic control is a prerequisite to guarantee the equal distribution of the genetic material onto the two developing daughter cells. A mitotic key regulator is cyclin B. High levels of cyclin B facilitate entry into mitosis whereas its controlled degradation coordinates chromosome separation and cytokinesis. The latter events are coordinated by the anaphase- promoting complex / cyclosome (APC/C), a ubiquitin ligase that couples ubiquitin chains to cyclin B, mediating its proteasomal degradation. The regulation of the APC/C-activity by complex protein networks, su

APA, Harvard, Vancouver, ISO, and other styles

26

Saatci, Ozge, Ozge Akbulut, Metin Cetin, et al. "Abstract PO4-24-04: Identifying the interactome of TACC3, a major driver in aggressive cancer cells with centrosome amplification." Cancer Research 84, no. 9_Supplement (2024): PO4–24–04—PO4–24–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-24-04.

Full text

Abstract:

Abstract Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) is a centrosome- and spindle-associated protein that drives the growth of highly aggressive tumors, such as those with centrosome amplification (CA). In recent years, it has become apparent that TACC3 not only functions at the centrosomes and spindles but may also have many other non-canonical functions facilitating the growth of tumors. Given the multifaceted roles of TACC3 in driving tumor aggressiveness, the identification of novel interactors of TACC3 that are responsible for mediating key TACC3-driven processes is cruci

APA, Harvard, Vancouver, ISO, and other styles

27

O'Connell, Christopher B., and Yu-li Wang. "Mammalian Spindle Orientation and Position Respond to Changes in Cell Shape in a Dynein-dependent Fashion." Molecular Biology of the Cell 11, no. 5 (2000): 1765–74. http://dx.doi.org/10.1091/mbc.11.5.1765.

Full text

Abstract:

In animal cells, positioning of the mitotic spindle is crucial for defining the plane of cytokinesis and the size ratio of daughter cells. We have characterized this phenomenon in a rat epithelial cell line using microscopy, micromanipulation, and microinjection. Unmanipulated cells position the mitotic spindle near their geometric center, with the spindle axis lying roughly parallel to the long axis of the cell. Spindles that were initially misoriented underwent directed rotation and caused a delay in anaphase onset. To gain further insight into this process, we gently deformed cells with a b

APA, Harvard, Vancouver, ISO, and other styles

28

Czajkowski, Emily R., Yuntong Zou, Nikita S. Divekar, and Sarah M. Wignall. "The doublecortin-family kinase ZYG-8DCLK1 regulates microtubule dynamics and motor-driven forces to promote the stability of C. elegans acentrosomal spindles." PLOS Genetics 20, no. 9 (2024): e1011373. http://dx.doi.org/10.1371/journal.pgen.1011373.

Full text

Abstract:

Although centrosomes help organize spindles in most cell types, oocytes of most species lack these structures. During acentrosomal spindle assembly in C. elegans oocytes, microtubule minus ends are sorted outwards away from the chromosomes where they form poles, but then these outward forces must be balanced to form a stable bipolar structure. Simultaneously, microtubule dynamics must be precisely controlled to maintain spindle length and organization. How forces and dynamics are tuned to create a stable bipolar structure is poorly understood. Here, we have gained insight into this question th

APA, Harvard, Vancouver, ISO, and other styles

29

Zhou, Wenhong, Liuzhou Zhong, Weimin Kang, Yuetong Xu, Congcong Luan, and Jianzhong Fu. "Modal Parameter Identification of Electric Spindles Based on Covariance-Driven Stochastic Subspace." Machines 12, no. 11 (2024): 774. http://dx.doi.org/10.3390/machines12110774.

Full text

Abstract:

Electric spindles are a critical component of numerically controlled machine tools that directly affect machining precision and efficiency. The accurate identification of the modal parameters of an electric spindle is essential for optimizing design, enhancing dynamic performance, and facilitating fault diagnosis. This study proposes a covariance-driven stochastic subspace identification (SSI-cov) method integrated with a simulated annealing (SA) strategy and fuzzy C-means (FCM) clustering algorithm to achieve the automated identification of modal parameters for electric spindles. Using both f

APA, Harvard, Vancouver, ISO, and other styles

30

Santibanez, Juan Francisco, Eduardo Pérez-Gómez, África Fernández-L, et al. "The TGF-b co-receptor endoglin modulates the expression and transforming potential of H-Ras." Carcinogénesis 31, no. 12 (2010): 2145–54. https://doi.org/10.1093/carcin/bgq199.

Full text

Abstract:

Endoglin is a coreceptor for transforming growth factor-β (TGF-β) that acts as a suppressor of malignancy during mouse skin carcinogenesis. Because in this model system H-Ras activation drives tumor initiation and progression, we have assessed the effects of endoglin on the expression of H-Ras in transformed keratinocytes. We found that TGF-β1 increases the expression of H-Ras at both messenger RNA and protein levels. The TGF-β1-induced H-Ras promoter transactivation was Smad4 independent but mediated by the activation of the TGF-β type I receptor ALK5 and the Ras-mito

APA, Harvard, Vancouver, ISO, and other styles

31

Galardy, Paul J., and Ying Zhang. "USP44 Is Highly Over-Expresed In T-Cell Acute Lymphoblastic Leukemia and Leads to the Development of Chromosome Missegregation and Aneupoloidy." Blood 116, no. 21 (2010): 29. http://dx.doi.org/10.1182/blood.v116.21.29.29.

Full text

Abstract:

Abstract Abstract 29 Acute lymphoblastic leukemia (ALL) cells are frequently characterized by abnormal numbers of chromosomes, a condition known as aneuploidy. Aneuploidy in ALL is not just a curiosity, but impacts on the prognosis and risk stratification in children. Additionally, aneuploidy itself contributes to the development of cancer by dysregulating gene expression, and driving the loss of heterozygosity of mutated tumor suppressor genes. The molecular underpinnings of aneuploidy in ALL are largely unknown. The mitotic checkpoint is a complex pathway that acts in mitosis to prevent the

APA, Harvard, Vancouver, ISO, and other styles

32

Liu, Bing, Chunlian Jin, Nico De Storme, et al. "A Hypomorphic Mutant of PHD Domain Protein Male Meiocytes Death 1." Genes 12, no. 4 (2021): 516. http://dx.doi.org/10.3390/genes12040516.

Full text

Abstract:

Meiosis drives reciprocal genetic exchanges and produces gametes with halved chromosome number, which is important for the genetic diversity, plant viability, and ploidy consistency of flowering plants. Alterations in chromosome dynamics and/or cytokinesis during meiosis may lead to meiotic restitution and the formation of unreduced microspores. In this study, we isolated an Arabidopsis mutant male meiotic restitution 1 (mmr1), which produces a small subpopulation of diploid or polyploid pollen grains. Cytological analysis revealed that mmr1 produces dyads, triads, and monads indicative of mal

APA, Harvard, Vancouver, ISO, and other styles

33

Lane, Heidi A., Felix Bachmann, Elisa Zanini, et al. "Abstract 5645: BAL0891: A novel dual TTK/PLK1 mitotic checkpoint inhibitor (MCI) that drives aberrant tumor cell division resulting in potent anti-cancer activity." Cancer Research 82, no. 12_Supplement (2022): 5645. http://dx.doi.org/10.1158/1538-7445.am2022-5645.

Full text

Abstract:

Abstract Background: BAL0891 is a dual inhibitor of threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1). These kinases collaborate in activating the mitotic spindle assembly checkpoint (SAC) at the kinetochore (KT) to regulate chromosome alignment and segregation prior to mitotic exit. In vitro, BAL0891 has a combined prolonged effect on TTK and a transient effect on PLK1, leading to rapid disruption of the SAC that potentiates aberrant mitotic progression of tumor cells. In this work, efficacy of BAL0891 was investigated in mouse models of human triple negative breast cancer (TNBC)

APA, Harvard, Vancouver, ISO, and other styles

34

Lee, Meng-Hua, Kevin Louault, Krinio Giannikou, et al. "Abstract 3543: Mesenchymal stromal cells and tumor-associated macrophages modulate adrenergic to mesenchymal state switching in neuroblastoma." Cancer Research 83, no. 7_Supplement (2023): 3543. http://dx.doi.org/10.1158/1538-7445.am2023-3543.

Full text

Abstract:

Abstract Neuroblastoma (NB), a common solid tumor of children, can adopt a lineage-committed adrenergic (ADRN) or an immature mesenchymal (MES) tumor cell type, which differs in phenotype, epigenetic landscape, transcription factors, and core regulatory circuitries. These cell types can spontaneously interconvert, but the mechanism remains largely unknown. Here, we hypothesize that the tumor-associated macrophages (TAM) and cancer-associated fibroblast (CAF) within the tumor microenvironment contribute to pro-tumorigenic factors production and drive switching from ADRN to MES state in neurobla

APA, Harvard, Vancouver, ISO, and other styles

35

Rose, L. S., and K. Kemphues. "The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo." Development 125, no. 7 (1998): 1337–46. http://dx.doi.org/10.1242/dev.125.7.1337.

Full text

Abstract:

The orientation of cell division is a critical aspect of development. In 2-cell C. elegans embryos, the spindle in the posterior cell is aligned along the long axis of the embryo and contributes to the unequal partitioning of cytoplasm, while the spindle in the anterior cell is oriented transverse to the long axis. Differing spindle alignments arise from blastomere-specific rotations of the nuclear-centrosome complex at prophase. We have found that mutations in the maternally expressed gene let-99 affect spindle orientation in all cells during the first three cleavages. During these divisions,

APA, Harvard, Vancouver, ISO, and other styles

36

Labbé, Jean-Claude, Erin K. McCarthy, and Bob Goldstein. "The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly." Journal of Cell Biology 167, no. 2 (2004): 245–56. http://dx.doi.org/10.1083/jcb.200406008.

Full text

Abstract:

Regulation of the mitotic spindle's position is important for cells to divide asymmetrically. Here, we use Caenorhabditis elegans embryos to provide the first analysis of the temporal regulation of forces that asymmetrically position a mitotic spindle. We find that asymmetric pulling forces, regulated by cortical PAR proteins, begin to act as early as prophase and prometaphase, even before the spindle forms and shifts to a posterior position. The spindle does not shift asymmetrically during these early phases due to a tethering force, mediated by astral microtubules that reach the anterior cel

APA, Harvard, Vancouver, ISO, and other styles

37

Zanini, Elisa, Nicole Forster-Gross, Felix Bachmann, et al. "Abstract 5646: BAL0891: A novel, small molecule, dual TTK/PLK1 mitotic checkpoint inhibitor (MCI) that drives aberrant tumor cell division." Cancer Research 82, no. 12_Supplement (2022): 5646. http://dx.doi.org/10.1158/1538-7445.am2022-5646.

Full text

Abstract:

Abstract Background: BAL0891 is a dual inhibitor of threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1). These kinases collaborate in activating the mitotic spindle assembly checkpoint (SAC) at the kinetochore (KT) to regulate chromosome alignment and segregation prior to mitotic exit. In this work, kinase inhibition by BAL0891 was linked to effects on SAC integrity and aberrant mitotic progression in tumor cells. Comparison with a TTK-specific inhibitor (CFI-402257, CFI) allowed further evaluation of the contribution of dual TTK/PLK1 inhibition to anti-cancer activity, associated wi

APA, Harvard, Vancouver, ISO, and other styles

38

Setiawan, Fredy, Dedy Pradigdo, and Marga Firnanda Sriminangga. "Otomotif Kendaraan Tempur ANALISA PENGEMBANGAN CNC MILLING 5 AXIS BERBASIS MICROCONTROLLER DENGAN MOTOR DRIVER TB 6600." Jurnal Otoranpur 3, Mei (2022): 19–26. http://dx.doi.org/10.54317/oto.v3imei.219.

Full text

Abstract:

Mesin CNC adalah mesin yang di kendalikan oleh komputer yang diprogram inputan data dengan kode angka, huruf maupun simbol. Dimana mesin CNC 5 axis merupakan gabungan antara 3 Axis dan 2 Axis yang berkaitan menjadi satu dalam kinerja mesin. Mesin CNC 5 Axis mempunyai 5 sumbu yaitu X, Y, Z dan A, B yang proses kerjanya milling benda kerja yang terbentuk 3D. Dalam penelitian ini, ada permasalahan pada mesin CNC 5 Axis dalam kekuatan batang ulir yang menompang beban disaat proses kerja milling dimana batang ulir akan mengalami gaya geser yang cukup berat. Oleh karena itu, pengembangan analisa mes

APA, Harvard, Vancouver, ISO, and other styles

39

Zhang, Xi, Sheng Bao, and Fang Cheng. "Measurement of Radial and Axial Error Motion in a High Precision Spindle." Advanced Materials Research 381 (November 2011): 34–37. http://dx.doi.org/10.4028/www.scientific.net/amr.381.34.

Full text

Abstract:

The performance of a spindle is critical for high precision machining. In this paper, the spindle error motion in a high precision milling center was measured. The spindle is driven by air turbine with rotation speed of 120,000rpm. The radial and axial error motion of the axis of rotation was measured. The capacitive displacement sensors with nanometer resolution were mounted against the master gauge pin through the dedicated setup. Tlusty method was adopted to synchronize angular position of the spindle and data sampling. The measured radial and axial error motion of the spindle were 2.73μm a

APA, Harvard, Vancouver, ISO, and other styles

40

Han, Pei Cen, Zhao Hui Ye, Yong Ming Zhou, and Shi Yuan Yang. "SOPC-Based Motion Controller with NURBS Interpolator." Advanced Materials Research 898 (February 2014): 937–43. http://dx.doi.org/10.4028/www.scientific.net/amr.898.937.

Full text

Abstract:

SOPC becomes popular nowadays, which combines software and hardware in a single chip. In this paper, a multi-axis motion controller is implemented based on a SOPC system with a NIOSII processor in a single FPGA chip. The motion controller includes DDA module, spindle module and NURBS calculation module realized in Verilog HDL. DDA algorithm is used to drive the motors while spindle module is to drive the spindle. Because of NURBS recursive nature, NURBS calculation module is used to accelerate the calculation which takes the advantage of parallel structure. The NIOSII processor realizes the fe

APA, Harvard, Vancouver, ISO, and other styles

41

Majda, Paweł, and Bartosz Powałka. "Accuracy and repeatability positioning of high-performancel athe for non-circular turning." Archives of Mechanical Technology and Materials 37, no. 1 (2017): 85–90. http://dx.doi.org/10.1515/amtm-2017-0014.

Full text

Abstract:

AbstractThis paper presents research on the accuracy and repeatability of CNC axis positioning in an innovative lathe with an additional Xsaxis. This axis is used to perform movements synchronized with the angular position of the main drive, i.e. the spindle, and with the axial feed along the Z axis. This enables the one-pass turning of non-circular surfaces, rope and trapezoidal threads, as well as the surfaces of rotary tools such as a gear cutting hob, etc. The paper presents and discusses the interpretation of results and the calibration effects of positioning errors in the lathe’s numeric

APA, Harvard, Vancouver, ISO, and other styles

42

Mitsialis, V., M. Losa, C. Lance, et al. "DOP072 The IL1-dependent transcription factor MEOX1 as a driver of differentiation programs in ACKR1+ endothelial cells of inflammatory bowel disease granulation tissue." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i217. https://doi.org/10.1093/ecco-jcc/jjae190.0111.

Full text

Abstract:

Abstract Background Activated endothelial cells (ECs) are expanded in IBD tissue and express ACKR11, a chemokine receptor known to mark venular endothelium and enable immune cell trafficking. ACKR1+ ECs have been reported in diseases associated with inflammation and/or fibrosis2, although their role in stromal differentiation is unclear. We investigated the relationship between IL1 and inflammation in IBD and identified an IL1-dependent transcription factor (TF), MEOX1, known to regulate fibrosis in cardiac ischemia3 that is associated with IBD ulcers and expressed in ACKR1+ ECs. Methods We as

APA, Harvard, Vancouver, ISO, and other styles

43

Horiuchi, Osamu, Mitsuyoshi Nomura, Bo Xiao Ma, Takayuki Shibata, Yoshihiko Murakami, and Masami Masuda. "Influence of Thermal Behavior of Spindle on Machining Accuracy in Micro-Endmilling." Advanced Materials Research 418-420 (December 2011): 2040–45. http://dx.doi.org/10.4028/www.scientific.net/amr.418-420.2040.

Full text

Abstract:

This paper describes on the influence of thermal behavior of spindle on machining accuracy in micro-endmilling. In order to make clear the reasons why the depth of slot varies during slotting repeated, temperatures around the spindle head and the thermal expansion of spindle axis were investigated. The machine tool used for experiment was a small type of vertical machining center. The spindle used for experiment was a ball bearing spindle which rotated at 10000-40000 min-1. The spindle head made of aluminum alloy had various cooling systems for spindle motor and ball bearings, and the temperat

APA, Harvard, Vancouver, ISO, and other styles

44

Guo, Yong Feng, Ze Bin Ling, Kai Zhang, and Ye Rui Feng. "Model Structure and Simulation Analysis of a Novel Magetic Suspension Spindle Apparatus for Micro EDM." Advanced Materials Research 941-944 (June 2014): 2121–26. http://dx.doi.org/10.4028/www.scientific.net/amr.941-944.2121.

Full text

Abstract:

In the Micro Electronic Discharge Manufacture (The diameter of electrode is no more than 0.5mm), the response frequency of the spindle in Z axis is too low to satisfy the requirement of rapid response. Considering this problem, a novel spindle apparatus based on the Magnetic Suspension drive principle is proposed in this paper, the basic structure and principle are introduced. At the same time, the Magnetic field distribution and they are analyzed by the finite element software Ansoft Maxwell. Theory conduction and simulation results indicates that the response frequency of the spindle and the

APA, Harvard, Vancouver, ISO, and other styles

45

Schulze, Harald, Marei Dose, Manav Korpal, Joseph E. Italiano, and Ramesh A. Shivdasani. "RanBP10 Is a Cytoplasmic GDP/GTP Exchange Factor That Modulates Microtubule Dynamics in Late Megakaryocytes." Blood 106, no. 11 (2005): 738. http://dx.doi.org/10.1182/blood.v106.11.738.738.

Full text

Abstract:

Abstract Megakaryocytes are large cells within the bone marrow that undergo complex fragmentation to release up to thousands of virtually identical blood platelets into the periphery. Each platelet contains a characterisitic microtubule (MT) marginal band that is derived from MT filaments present in long protrusion-like intermediate structures, designated proplatelets, that are immediate precursors of platelets. These MT filaments are generated in the MK periphery, where they require massive mobilization that is supposed to be different from either normal interphase MT nucleation that commonly

APA, Harvard, Vancouver, ISO, and other styles

46

Thompson, Zanshe, Li Z. Luo, Liping Li, et al. "Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in JAK2 V617F Myeloproliferative Neoplasms." Blood 142, Supplement 1 (2023): 3145. http://dx.doi.org/10.1182/blood-2023-190323.

Full text

Abstract:

Introduction: Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by hyperactive JAK/STAT signaling, thromboses, abnormal bleeding, and increased risk of transformation to myelofibrosis (MF) or acute myeloid leukemia (AML). Importantly, clinical outcomes are poor after transformation and actionable mechanisms that drive progression remain elusive. We discovered that High Mobility Group A1 ( HMGA1) chromatin regulators are required for transformation to AML in preclinical models of MPN by up-regulating transcriptional networks involved in GATA2 an

APA, Harvard, Vancouver, ISO, and other styles

47

Rankin, Kathleen E., and Linda Wordeman. "Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow." Journal of Cell Biology 190, no. 1 (2010): 35–43. http://dx.doi.org/10.1083/jcb.201004017.

Full text

Abstract:

Astral microtubules (MTs) are known to be important for cleavage furrow induction and spindle positioning, and loss of astral MTs has been reported to increase cortical contractility. To investigate the effect of excess astral MT activity, we depleted the MT depolymerizer mitotic centromere-associated kinesin (MCAK) from HeLa cells to produce ultra-long, astral MTs during mitosis. MCAK depletion promoted dramatic spindle rocking in early anaphase, wherein the entire mitotic spindle oscillated along the spindle axis from one proto-daughter cell to the other, driven by oscillations of cortical n

APA, Harvard, Vancouver, ISO, and other styles

48

Kropivny, Oleksandr, Andrii Hrechka, Andrii Kyrychenko, and Kyryl Shcherbyna. "Kinematic Dependencies of Two-axis Parallel Manipulator With Rotary Fastening of Hinges of Variable Length Links." Central Ukrainian Scientific Bulletin. Technical Sciences 2, no. 5(36) (2022): 22–30. http://dx.doi.org/10.32515/2664-262x.2022.5(36).2.22-30.

Full text

Abstract:

In the article the kinematic problem for a new two-axis parallel manipulator with rotary hinged parallelogram, the source of which is a spindle unit, is performed. The analysis of the received kinematic dependencies is carried out. The presence of special provisions of the source body of the mechanism is established. The directions of further scientific researches are outlined. The parallel manipulator structure for consideration differs from previously developed fastenings of hinges of rods of variable length on rotary levers which rotation is coordinated with rotation of an initial link with

APA, Harvard, Vancouver, ISO, and other styles

49

Handono, Sulis Dri, Bangkit Setyo Nugroho, and Lalu Saefullah. "RANCANG BANGUN ROTARY TABLE PADA CNC MILLING 5 AXIS MICROCONTROLLER." Jurnal Otoranpur 3, no. 2 (2023): 56–62. http://dx.doi.org/10.54317/oto.v3ioktober.332.

Full text

Abstract:

Teknologi dalam dunia militer sudah semakin berkembang dengan adanya inovasi teknologi yang dinamakan mesin CNC 5 Milling Axis. Mesin ini memiliki 5 sumbu yakni X,Y,Z dan A,B. mesin ini dikendalikan oleh komputer yang dimana program dari komputer itu memiliki kode angka, huruf maupun symbol. Dalam penelitian ini dibahas tentang rotary table yang dimana pada kekuatan setiap rotarynya akan memiliki tumpuan yang berbeda. Pada mesin ini akan memilih batang ulir sebagai alat penggerak sumbu yang dimana akan digerakkan oleh motor stepper dan motor driver. Metode yang digunakan dalam penelitian ini a

APA, Harvard, Vancouver, ISO, and other styles

50

Giannikopoulos, Petros, and David M. Parham. "Rhabdomyosarcoma: How Advanced Molecular Methods Are Shaping the Diagnostic and Therapeutic Paradigm." Pediatric and Developmental Pathology 24, no. 5 (2021): 395–404. http://dx.doi.org/10.1177/10935266211013621.

Full text

Abstract:

For the past 40 years, progress in rhabdomyosarcoma (RMS) has been focused on understanding its molecular basis and characterizing the mutations that drive its tumorigenesis and progression. Genetic predisposition to RMS has allowed discovery of key genetic pathways and driver mutations. Subclassification of RMS into embryonal (ERMS) and alveolar (ARMS) subtypes has shifted from histology to PAX-FOXO1 fusion status, and new driver mutations have been found in spindle cell RMS. Comprehensive molecular profiling leveraging genome-scale next-generation sequencing (NGS) indicates that the RAS/RAF/

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!