Academic literature on the topic 'Spinal motoneuron'
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Journal articles on the topic "Spinal motoneuron"
Kuo, Jason J., Martijn Schonewille, Teepu Siddique, Annet N. A. Schults, Ronggen Fu, Peter R. Bär, Roberta Anelli, C. J. Heckman, and Alfons B. A. Kroese. "Hyperexcitability of Cultured Spinal Motoneurons From Presymptomatic ALS Mice." Journal of Neurophysiology 91, no. 1 (January 2004): 571–75. http://dx.doi.org/10.1152/jn.00665.2003.
Full textQuinlan, K. A., E. J. Reedich, W. D. Arnold, A. C. Puritz, C. F. Cavarsan, C. J. Heckman, and C. J. DiDonato. "Hyperexcitability precedes motoneuron loss in the Smn2B/− mouse model of spinal muscular atrophy." Journal of Neurophysiology 122, no. 4 (October 1, 2019): 1297–311. http://dx.doi.org/10.1152/jn.00652.2018.
Full textBrownstone, Robert M., and Camille Lancelin. "Escape from homeostasis: spinal microcircuits and progression of amyotrophic lateral sclerosis." Journal of Neurophysiology 119, no. 5 (May 1, 2018): 1782–94. http://dx.doi.org/10.1152/jn.00331.2017.
Full textIwagaki, Noboru, and Gareth B. Miles. "Activation of group I metabotropic glutamate receptors modulates locomotor-related motoneuron output in mice." Journal of Neurophysiology 105, no. 5 (May 2011): 2108–20. http://dx.doi.org/10.1152/jn.01037.2010.
Full textLi, Y., X. Li, P. J. Harvey, and D. J. Bennett. "Effects of Baclofen on Spinal Reflexes and Persistent Inward Currents in Motoneurons of Chronic Spinal Rats With Spasticity." Journal of Neurophysiology 92, no. 5 (November 2004): 2694–703. http://dx.doi.org/10.1152/jn.00164.2004.
Full textDaló, N. L., J. C. Hackman, K. Storey, and R. A. Davidoff. "Changes in motoneuron membrane potential and reflex activity induced by sudden cooling of isolated spinal cords: differences among cold-sensitive, cold-resistant and freeze-tolerant amphibian species." Journal of Experimental Biology 198, no. 8 (August 1, 1995): 1765–74. http://dx.doi.org/10.1242/jeb.198.8.1765.
Full textHochman, S., and D. A. McCrea. "Effects of chronic spinalization on ankle extensor motoneurons. I. Composite monosynaptic Ia EPSPs in four motoneuron pools." Journal of Neurophysiology 71, no. 4 (April 1, 1994): 1452–67. http://dx.doi.org/10.1152/jn.1994.71.4.1452.
Full textMaltenfort, Mitchell G., C. J. Heckman, and W. Zev Rymer. "Decorrelating Actions of Renshaw Interneurons on the Firing of Spinal Motoneurons Within a Motor Nucleus: A Simulation Study." Journal of Neurophysiology 80, no. 1 (July 1, 1998): 309–23. http://dx.doi.org/10.1152/jn.1998.80.1.309.
Full textYamamoto, Y., J. Livet, R. A. Pollock, A. Garces, V. Arce, O. deLapeyriere, and C. E. Henderson. "Hepatocyte growth factor (HGF/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons." Development 124, no. 15 (August 1, 1997): 2903–13. http://dx.doi.org/10.1242/dev.124.15.2903.
Full textSmith, J. C., J. J. Greer, G. S. Liu, and J. L. Feldman. "Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity." Journal of Neurophysiology 64, no. 4 (October 1, 1990): 1149–69. http://dx.doi.org/10.1152/jn.1990.64.4.1149.
Full textDissertations / Theses on the topic "Spinal motoneuron"
Narayan, Sreenath. "REANIMATION OF A DENERVATED MUSCLE USING UPPER MOTONEURON INJURED LOWER MOTONEURONS IN SPINAL CORD INJURY PATIENTS: A RAT MODEL." online version, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1133754830.
Full textChopek, Jeremy W. "Lumbar spinal cord excitability: flexors vs. extensors, sensitivity to quipazine; effects of activity following spinal transection; and expression of post-synaptic serotonin receptors." American Physiological Society, 2013. http://hdl.handle.net/1993/24099.
Full textArumugam, Saravanan. "A Study on the Role of NF-kB Signaling Pathway Members in Regulating Survival Motor Neuron Protein level and in the Pathogenesis of Spinal Muscular Atrophy." Doctoral thesis, Universitat de Lleida, 2017. http://hdl.handle.net/10803/400607.
Full textLa Atrofia Muscular Espinal (SMA) es un trastorno neuromuscular causado por la mutación o deleción del gen SMN1, el cual codifica para la proteína que se expresa ubicuamente SMN (del inglés Survival Motor Neuron). La AME se caracteriza por atrofia muscular y degeneración de las motoneuronas de la médula espinal (MN). Los eventos moleculares detrás de la vulnerabilidad selectiva de las MN con niveles bajos de la proteína SMN se desconocen. La vía del factor nuclear-kB (NF-kB) ha sido implicada recientemente en la supervivencia de las MNs, así como en trastornos neurodegenerativos. Los factores de transcripción NF-kB regulan genes relacionados con varios procesos celulares. En este trabajo hemos analizado la capacidad de los miembros de la vía del NF-κB de regular la proteína SMN y su posible rol en la patogénesis del AME. La activación de la vía del NF-κB está asociada a la fosforilación de IKKα / IKKβ y la translocación nuclear del factor RelA/ p50 (vía canónica) o la fosforilación del homodímero de IKKα y la translocación nuclear del factor RelB / p52 (vía no canónica). Hemos realizado la inhibición de diferentes miembros de estas vías (tanto la canónica como la no canónica) usando la metodología de shRNA, y la transducción mediante el uso de lentivirus, en cultivos primarios de MN embrionarias aisladas de ratón. Hemos demostrado que una reducción selectiva del factor RelA provoca una reducción de la proteína SMN, mientras que una reducción del factor RelB no tiene ningún efecto en los niveles de la SMN. En nuestro modelo celular, la reducción de las proteínas IKKα o IKKβ mostró efectos opuestos sobre la proteína Smn. Mediante la técnica de PCR, hemos observado que la transducción de las MN con el shIKKβ provoca un aumento de los niveles de mRNA de SMN, mientras que la transducción con el shIKKα o el shRelA no cambian los niveles de RNA de SMN. El doble knockdown de IKKα e IKKβ en las MN muestra una reducción de SMN. El knockdown selectivo de IKKα o IKKβ presenta una reducción de la fosforilación del RelA, esta fosforilación permite la liberación de su inhibidor en el citosol y facilita la translocación nuclear. La proteína CREB, uno de los factores de transcripción conocidos para SMN, disminuye con la transducción de las MN con shIKKα o con IKKα e IKKβ a la vez, así como con shRelA. Ahora bien, las motoneuronas transducidas con shIKKβ muestran una reducción de la fosforilación de RelA pero un aumento de los niveles de la proteína CREB. La transducción de las MN con el shCREB disminuyó los niveles de la proteína SMN apoyando el papel regulador de CREB sobre SMN.
Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutation or loss in SMN1 gene, encoding the ubiquitously expressed Survival Motor Neuron (SMN) protein. SMA is characterized by muscle atrophy, and spinal cord motoneurons (MNs) degeneration. The molecular events behind the selective vulnerability of these MNs to low level of SMN protein are still unknown. The nuclear factor-κB (NF-κB) pathway has recently been emerged having a vital role related to MN survival, and in neurodegenerative disorders. The NF-κB transcription factors regulate genes related to several cellular processes. In the present work, we have analyzed the ability of NF-κB pathway members to regulate Smn and their possible role in SMA pathogenesis. The NF-κB pathway activation is associated with IKKα/IKKβ phosphorylation, and RelA/p50 nuclear translocation (canonical) or IKKα homodimer phosphorylation, and RelB/p52 nuclear translocation (non-canonical). The inhibition of different protein members of both canonical, and non-canonical pathways using shRNA lentiviral transduction methodology in a primary culture of isolated embryonic spinal cord MNs reveals that the selective reduction of RelA induced the reduction of Smn whereas RelB protein reduction had no effect on Smn. In our culture system, reduction of IKKα or IKKβ proteins showed opposite effects on Smn. RT-PCR studies indicate that the shIKKβ-transduced MNs showed increased Smn mRNA levels, whereas it was not observed changes in Smn mRNA in the case of shIKKα- or shRelA-transduced MNs. The double knock-down of IKKα and IKKβ in MNs showed Smn reduction. The knockdown of IKKα and/or IKKβ showed a decrease in RelA phosphorylation, where the phosphorylation of RelA enable RelA/p50 release from its inhibitor in the cytoplasm and facilitates their nuclear translocation. Also, the CREB, one of the transcription factors for Smn was decreased in shIKKα, or in shIKKα- plus IKKβ-transduced MNs, and as well as in shRelA-transduced MNs. But, the shIKKβ MNs exhibited reduced p-RelA but increased CREB level. The shCREB-transduced MNs decreased Smn level, authenticating the regulatory role of CREB on Smn. We observed a reduction in IKKα, IKKβ and p-RelA levels in shSmn-tranduced MNs, and in MNs from a severe type SMA mouse model. Our results show the ability of NF-κB canonical pathway to regulate Smn level and, conversely, this pathway is also altered in Smn-deficient MNs. Together, these observations suggest that the NF-κB pathway has a role in SMA pathogenesis, and could be a therapeutic target for SMA.
Sowd, Matthew Michael. "Analyzing Non-Unique Parameters in a Cat Spinal Cord Motoneuron Model." Thesis, Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/11545.
Full textRademacher, Sebastian [Verfasser]. "Cytoskeletal dysregulation in the motoneuron disease Spinal Muscular Atrophy (SMA) / Sebastian Rademacher." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2017. http://d-nb.info/1136298002/34.
Full textZelano, Johan. "Adhesion molecules and synapse remodeling during motoneuron regeneration." Stockholm : Department of Neuroscience, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-623-1/.
Full textVan, Ryswyk Liesl, and Ryswyk Liesl Van. "A Question of Identity: Genes that Distinguish Motoneurons from Interneurons." Thesis, University of Oregon, 2012. http://hdl.handle.net/1794/12539.
Full text柴宏 and Hong Chai. "Survival and regeneration of spinal motoneuron after ventral root avulsion in adult rat." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B3124158X.
Full textChai, Hong. "Survival and regeneration of spinal motoneuron after ventral root avulsion in adult rat /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?
Full textObeidat, Ahmed Zayed. "New Insights into the Spinal Recurrent Inhibitory Pathway Normally and After Motoneuron Regeneration." Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1369702090.
Full textBooks on the topic "Spinal motoneuron"
Krammer, Eva B., Martin F. Lischka, Thomas P. Egger, Maria Riedl, and Helmut Gruber. The Motoneuronal Organization of the Spinal Accessory Nuclear Complex. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-10362-3.
Full textMason, Peggy. Spinal Cord. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0004.
Full textGruber, Helmut, Eva B. Krammer, Martin F. Bach, Thomas P. Egger, and Maria Riedl. The Motoneuronal Organization of the Spinal Accessory Nuclear Complex. Springer, 1987.
Find full text1944-, Krammer E. B., ed. The Motoneuronal organization of the spinal accessory nuclear complex. Berlin: Springer-Verlag, 1987.
Find full textMason, Peggy. Introduction to the Nervous System. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0001.
Full textMason, Peggy. Reflexes and Gait. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0022.
Full text(Editor), T. Kumazawa, L. Kruger (Editor), and K. Mizumura (Editor), eds. The Polymodal Receptor - A Gateway to Pathological Pain (Progress in Brain Research). Elsevier Science, 1996.
Find full textTakao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Amsterdam: Elsevier, 1996.
Find full textBook chapters on the topic "Spinal motoneuron"
Burke, Robert. "Spinal Motoneurons." In Neuroscience in the 21st Century, 1027–62. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-1997-6_33.
Full textBurke, Robert. "Spinal Motoneurons." In Neuroscience in the 21st Century, 1153–88. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3474-4_33.
Full textAdeeb, Nimer, R. Shan Tubbs, Aman Deep, and Martin M. Mortazavi. "Locomotor Recovery After Spinal Cord Transection: Transplantation of Oligodendrocytes and Motoneuron Progenitors from Human Embryonic Stem Cells." In Stem Cells and Cancer Stem Cells, Volume 13, 55–71. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-7233-4_5.
Full textErceg, Slaven, and Miodrag Stojkovic. "Locomotor Recovery After Spinal Cord Transection: Transplantation of Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells." In Tumors of the Central Nervous System, Volume 6, 211–19. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2866-0_24.
Full textPowers, Randy. "Compartmental Models of Spinal Motoneurons." In Encyclopedia of Computational Neuroscience, 1–9. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-7320-6_741-1.
Full textPowers, Randy. "Compartmental Models of Spinal Motoneurons." In Encyclopedia of Computational Neuroscience, 660–67. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4614-6675-8_741.
Full textJiang, Z. G., and N. J. Dun. "Actions of Acetylcholine on Spinal Motoneurons." In Neurobiology of Acetylcholine, 283–93. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5266-2_23.
Full textJuurlink, Bernhard H. J. "Chick Spinal Somatic Motoneurons in Culture." In Protocols for Neural Cell Culture, 77–89. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-4757-2586-5_5.
Full textMilligan, Carol, and David Gifondorwa. "Isolation and Culture of Postnatal Spinal Motoneurons." In Methods in Molecular Biology, 77–85. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-328-8_5.
Full textBrock, L. G., J. S. Coombs, and J. C. Eccles. "Antidromic Propagation of Impulses into Motoneurones." In Ciba Foundation Symposium - The Spinal Cord, 120–31. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470718827.ch11.
Full textConference papers on the topic "Spinal motoneuron"
Gamal, Mai, Mohamed H. Mousa, Seif Eldawlatly, and Sherif M. Elbasiouny. "Automated Cell-Type Classification and Death-Detection of Spinal Motoneurons." In 2018 9th Cairo International Biomedical Engineering Conference (CIBEC). IEEE, 2018. http://dx.doi.org/10.1109/cibec.2018.8641824.
Full textMousa, Mohamed H., Ahmed H. Kandil, and Sherif M. Elbasiouny. "Simulation of dendritic L-type ca channels' warm-up phenomenon in spinal motoneurons." In 2016 8th Cairo International Biomedical Engineering Conference (CIBEC). IEEE, 2016. http://dx.doi.org/10.1109/cibec.2016.7836113.
Full textAbdelaal, Amr Y., Mohamed H. Mousa, Mai Gamal, Mahmoud I. Khalil, Sherif M. Elbasiouny, and Seif Eldawlatly. "A Classification Approach to Recognize the Firing of Spinal Motoneurons in Amyotrophic Lateral Sclerosis." In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) in conjunction with the 43rd Annual Conference of the Canadian Medical and Biological Engineering Society. IEEE, 2020. http://dx.doi.org/10.1109/embc44109.2020.9176551.
Full textKalinina, Natalia, Aleksey Zaitsev, and Nikolai Vesselkin. "CHANGE OF THE MODULATING INFLUENCE OF SEROTONIN ON THE FUNCTIONAL PROPERTIES OF SPINAL MOTONEURONS AFTER THEIR DAMAGE." In XVI International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1074.sudak.ns2020-16/238-239.
Full textBarra, Beatrice, Camille Roux, Melanie Kaeser, Giuseppe Schiavone, Stephanie P. Lacour, Jocelyne Bloch, Gregoire Courtine, Eric M. Rouiller, Eric Schmidlin, and Marco Capogrosso. "Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord." In 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2018. http://dx.doi.org/10.1109/embc.2018.8512554.
Full textKalinina, Natalia, Aleksey Zaitsev, and Nikolai Veselkin. "ROLE OF 5-HT 1B/D AND 5-HT 5A RECEPTORS IN MODULATION OF SYNAPTIC TRANSMISSION IN SPINAL MOTONEURONS." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2148.sudak.ns2021-17/175-176.
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