Academic literature on the topic 'SphK-1'
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Journal articles on the topic "SphK-1"
Venkataraman, Krishnan, Shobha Thangada, Jason Michaud, Myat Lin Oo, Youxi Ai, Yong-Moon Lee, Mingtao Wu, et al. "Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient." Biochemical Journal 397, no. 3 (July 13, 2006): 461–71. http://dx.doi.org/10.1042/bj20060251.
Full textWadgaonkar, Raj, Vipul Patel, Natalia Grinkina, Carol Romano, Jing Liu, Yutong Zhao, Saad Sammani, Joe G. N. Garcia, and Viswanathan Natarajan. "Differential regulation of sphingosine kinases 1 and 2 in lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 296, no. 4 (April 2009): L603—L613. http://dx.doi.org/10.1152/ajplung.90357.2008.
Full textSerrano-Sanchez, Martin, Zahra Tanfin, and Denis Leiber. "Signaling Pathways Involved in Sphingosine Kinase Activation and Sphingosine-1-Phosphate Release in Rat Myometrium in Late Pregnancy: Role in the Induction of Cyclooxygenase 2." Endocrinology 149, no. 9 (May 29, 2008): 4669–79. http://dx.doi.org/10.1210/en.2008-1756.
Full textMEACCI, Elisabetta, Francesca CENCETTI, Chiara DONATI, Francesca NUTI, Laura BECCIOLINI, and Paola BRUNI. "Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts." Biochemical Journal 381, no. 3 (July 27, 2004): 655–63. http://dx.doi.org/10.1042/bj20031636.
Full textAGEITOS, ARACELI TOBIO, GEETHANI BANDARA, ROSA MUNOZ-CANO, YUZHI YIN, AVANTI DESAI, DEAN METCALFE, and ANA OLIVERA. "Sphingosine Kinase Inhibitors Effectively Inhibit Growth of Mast Cells with D816V-KIT Mutations." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 145.13. http://dx.doi.org/10.4049/jimmunol.198.supp.145.13.
Full textMagli, Elisa, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Irene Saccone, Vincenzo Santagada, Giuseppe Caliendo, and Beatrice Severino. "Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments." Current Pharmaceutical Design 25, no. 9 (July 9, 2019): 956–68. http://dx.doi.org/10.2174/1381612825666190404115424.
Full textLynch, Kevin R. "Building a better sphingosine kinase-1 inhibitor." Biochemical Journal 444, no. 1 (April 26, 2012): e1-e2. http://dx.doi.org/10.1042/bj20120567.
Full textKharel, Yugesh, Mithun Raje, Ming Gao, Amanda M. Gellett, Jose L. Tomsig, Kevin R. Lynch, and Webster L. Santos. "Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate." Biochemical Journal 447, no. 1 (September 12, 2012): 149–57. http://dx.doi.org/10.1042/bj20120609.
Full textVessey, Donald A., Luyi Li, Zhu-Qiu Jin, Michael Kelley, Norman Honbo, Jianqing Zhang, and Joel S. Karliner. "A Sphingosine Kinase Form 2 Knockout Sensitizes Mouse Myocardium to Ischemia/Reoxygenation Injury and Diminishes Responsiveness to Ischemic Preconditioning." Oxidative Medicine and Cellular Longevity 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/961059.
Full textJo, Hyein, Kyeonghee Shim, and Dooil Jeoung. "The Crosstalk between FcεRI and Sphingosine Signaling in Allergic Inflammation." International Journal of Molecular Sciences 23, no. 22 (November 11, 2022): 13892. http://dx.doi.org/10.3390/ijms232213892.
Full textDissertations / Theses on the topic "SphK-1"
Almeida, Ana Carolina de. "Expressão de SIRP'alfa' e SPH-1 na anemia hemolitica autoimune." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308297.
Full textTese (doutorado)- Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-13T18:06:47Z (GMT). No. of bitstreams: 1 Almeida_AnaCarolinade_D.pdf: 1227023 bytes, checksum: 25438a379e180eeb0d1972b464b909b0 (MD5) Previous issue date: 2009
Resumo: SIRP 'alfa'(Signal Regulatory Protein 'alfa') é um receptor que medeia funções inibidoras em fagócitos. Sua ativação e conseqüente fosforilação dos ITIMs ocorre pela ligação ao CD47 presente na membrana dos eritrócitos, e permite o recrutamento e a ativação de SHP-1, a qual desfosforila substratos específicos envolvidos na mediação de diversos efeitos fisiológicos. O objetivo deste trabalho foi avaliar o papel da dexametasona (dexa) e de IFN?/TNFa sobre a expressão de SIRPa e SHP-1; a consequência desta regulação sobre a eritrofagocitose; e o nível de expressão gênica de SIRPa e SHP-1 em monócitos de pacientes com anemia hemolítica autoimune (AHAI) antes e depois de corticoterapia. Monócitos de doadores sadios e células mielomonocíticas U937 foram cultivados por 48 horas com dexa (1µM) ou IFN? (100U/ml) e TNFa (1000U/ml), por 6 horas com Hemina® (30uM), ou por 72 horas com prednisolona (0,15 e 1mg/l). Monócitos foram isolados de pacientes com AHAI antes e depois da corticoterapia. A expressão gênica de SIRPa e SHP-1 foi determinada por PCR em Tempo Real, a expressão protéica de SIRPa e SHP-1 foi determinada por Western Blotting, e a capacidade de eritrofagocitose foi determinada por microscopia. IFN? e TNFa, in vitro, promoveram o aumento da expressão gênica e protéica de SIRPa e a expressão gênica de SHP-1, em paralelo com a redução da capacidade de eritrofagocitose em monócitos normais. Em contrapartida, embora tenha aumentado a expressão gênica de SIRPa e SHP-1, dexa in vitro não alterou a expressão destas proteínas, assim como não alterou a capacidade de eritrofagocitose de monócitos normais. A expressão gênica de SIRPa e SHP-1 foi maior em monócitos de pacientes com AHAI em comparação a doadores sadios. Após corticoterapia, a expressão gênica de SIRPa e SHP-1 em monócitos de pacientes com AHAI se mostrou similar a doadores sadios. Pacientes com AHAI estudados antes da corticoterapia apresentaram baixos níveis de hemoglobina e após corticoterapia esse índice de mostrou normal. A expressão gênica de SIRPa foi aumentada pela cultura de monócitos com hemina, mas a expressão de proteína permaneceu a mesma. Nossos resultados confirmam o papel fundamental da SIRPa na regulação da eritrofagocitose e sugere que a expressão de mRNA de SIRPa em monócitos de pacientes com AHAI antes de corticoterapia é aumentada pela liberação de heme, e que a redução da expressão gênica de SIRPa após corticoterapia se deve a um efeito indireto desta droga pela redução da eritrofagocitose e diminuição da disponibilidade de heme.
Abstract: SIRPa (Signal Regulatory Protein a) is an inhibitory receptor in phagocytes. Its activation and consequent phosphorylation of ITIMs occurs by the binding to CD47 on erythrocyte membrane, what allows SHP-1 recruitment, which dephosphorylates specific substrates involved in the mediation of several physiologic effects. The aim of this work was to determine the role of dexamethasone and IFN?/TNFa upon SIRPa and SHP-1 expression, and the consequence of this regulation over erythrophagocytosis; and to evaluate the regulation of SIRPa and SHP-1 in peripheral blood monocytes (PBM) of autoimmune hemolytic anemia (AIHA) patients before and after glucocorticoid (GC) therapy. PBM from healthy donors and U937 myelomonocytic cells were cultured for 48 hours with dexamethasone (1µM) or IFN? (100U/ml) and TNFa (1000U/ml), for 6 hours with Hemin (30uM), or for 72 hours with prednisolone (0.15 and 1mg/l). PBM were isolated from AIHA patients under GC therapy or not. SIRPa and SHP-1 gene expression was determined by Real Time PCR, SIRPa and SHP-1 protein level was determined by Western Blotting, and erythrophagocytosis was determined by microscopy. IFN? and TNFa increased SIRPa gene and protein expression and SHP-1 gene expression, in parallel with a decrease in erythrophagocytosis ability in PBM. On the other hand, although SIRPa and SHP-1 gene expression was significantly increased, dexamethasone did not alter SIRPa and SHP-1 protein expression, and did not alter erythrophagocytosis ability in monocytes. SIRPa and SHP-1 expression was significantly higher in PBM from AIHA patients compared to normal. After GC therapy, SIRPa and SHP-1 expression was similar in PBM of AIHA patients compared to healthy donors. AIHA patients studied before glucocorticoid therapy showed low hemoglobin and after glucocorticoid therapy the level of hemoglobin was normal. SIRPa gene expression was increased by culture with hemin, but protein expression remained the same. Our results confirm the key role of SIRPa in erythrophagocytosis regulation and suggest that SIRPa mRNA expression in AIHA patients before glucocorticoid therapy is increased by heme release, and the decrease of SIRPa gene expression after glucocorticoid therapy is due to an indirect effect of this drug by the reduction of erythophagocytosis and free heme availability.
Doutorado
Doutor em Farmacologia
Le, Scolan Erwan Pierre Laurent. "Recherche d'altérations génétiques impliquées dans la transformation des proérythroblastes transgéniques pour spi-1 : dérégulation transcriptionnelle du gène codant pour la sphingosine kinase de type 1." Paris 7, 2005. http://www.theses.fr/2005PA077035.
Full textZhang, Xiwen. "KNOCKOUT OF SPHINGOSINE KINASE 1 ATTENUATES RENAL INTERSTITIAL FIBROSIS IN UNILATERAL URETERAL OBSTRUCTION (UUO) MODEL." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5010.
Full textGomez-Brouchet, Anne. "Rôle de la Sphingosine Kinase 1 (SphK1) dans la régulation de la survie des cellules de neuroblastome exposées au peptide Béta-amyloïde." Toulouse 3, 2007. http://www.theses.fr/2007TOU30251.
Full textAlzheimer disease (AD) is a critical problem of public health in the industrialized countries. AD affects 24. 3 million individuals in the world. In France, the number of AD patients represents 5 % of the population over 65 years-old (20 % of people over 85 years-old). Important progress have been made during the last ten years: Mutations were characterized, as well as genetic or environmental risk factors. A better analysis of the two elementary lesions of AD in their distribution and molecular characterization has allowed a better comprehension of the disease. Thus, the description of a dysfunction of proteins APP (Amyloid Precursor Protein) and Tau in sporadic and familial AD has led to therapeutic experiments and tests on cellular or animal models with promising results. Even though the diagnosis of AD still remains related to the neuropathology, it is evoked more precociously due to the progress in neuropsychological evaluation and imaging procedures. The advances in the comprehension of the disease mechanisms should make possible the discovery of new therapeutic targets. .
Drosos, Zacharias [Verfasser], Lars [Akademischer Betreuer] Hanker, and Markus [Akademischer Betreuer] Meier. "Die prognostische Bedeutung der Expression von Acid-Ceramidase (ASAH1) und Sphingosin-Kinase 1 (SPHK1) bei Patientinnen mit Ovarialkarzinom / Zacharias Drosos ; Akademische Betreuer: Lars Hanker, Markus Meier." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1236386272/34.
Full textBöhm, Andreas [Verfasser], Bernhard [Akademischer Betreuer] Rauch, and Joachim [Akademischer Betreuer] Ernst. "Regulation der Sphingosin-Kinase 1 (SPHK1) durch den aktivierten Gerinnungsfaktor X (FXa) und den Protease-aktivierten Rezeptor 2 (PAR-2) in glatten Gefäßmuskelzellen / Andreas Böhm. Gutachter: Bernhard Rauch ; Joachim Ernst." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1043802142/34.
Full textStillman, Anthony D. "Targeting Sphingosine Kinase 2 as a Treatment for Cholangiocarcinoma." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6067.
Full textGupta, Snehalata. "Molecular interactions among PAP-1, SPHs and proPO in activation of prophenoloxidase." 2004. http://digital.library.okstate.edu/etd/umi-okstate-1040.pdf.
Full textBooks on the topic "SphK-1"
O'Brien, Edel, and Catherine Deegan. My Wellbeing Journey 1: For Junior Cycle SPHE. M.H. Gill & Co. U. C., 2019.
Find full textHealthy Lifestyles 1: SPHE Activities for First Year Students. M.H. Gill & Co. U. C., 2008.
Find full textO'Brien, Edel, and Catherine Deegan. New Healthy Lifestyles 1: SPHE Activities for First Year. M.H. Gill & Co. U. C., 2014.
Find full textParamashivam, SPH Nithyananda. Nithya Katha 1: Stories from the Divine Discourses of the SPH Nithyananda Paramashivam. KAILASA's Nithyananda Hindu University Press, 2011.
Find full textBook chapters on the topic "SphK-1"
Bart, Arnaud, Thibault Macherel, Giovanni De Cesare, Sean Mulligan, and Khalid Essyad. "Vortex Siphon – From 1:1 Scale Physical Model to SPH Simulation and Prototype." In Advances in Hydroinformatics, 795–807. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5436-0_62.
Full textConference papers on the topic "SphK-1"
Drosos, Z., H. Gevensleben, S. Kommoss, T. Karn, U. Holtrich, M. Graeser-Mayer, M. Anglesio, A. El-Balat, A. Rody, and L. Hanker. "EP833 The prognostic impact of sphingosine-kinase 1 expression (SphK1) on ovarian cancer." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.882.
Full textHanker, LC, Z. Drosos, S. Kommoss, T. Karn, U. Holtrich, M. Graeser-Mayer, M. Anglesio, A. El-Balat, A. Rody, and H. Gevensleben. "Expression of Sphingosine-Kinase 1 (SPHK1) as a prognostic factor in ovarian cancer." In 62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe – DGGG'18. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1671643.
Full textBeach, Jessica A., Paul-Joseph Aspuria, Dong-Joo Cheon, Maricel C. Gozo, Beth Y. Karlan, and Sandra Orsulic. "Abstract B09: Sphingosine kinase 1 (SPHK1) is a novel mediator of tumor-stroma interaction in ovarian cancer." In Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; February 26 — March 1, 2014; San Diego, CA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.chtme14-b09.
Full textRafiee, Ashkan, Sharen Cummins, Murray Rudman, and Krish Thiagarajan. "The Effect of Pressure Solution in SPH Simulations of Sloshing Flow." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49215.
Full textKawashima, Yoichi, Yuzuru Sakai, and Nobuki Yamagata. "Large Deformation Analysis by Smoothed Particle Hydrodynamics." In ASME 2006 Pressure Vessels and Piping/ICPVT-11 Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/pvp2006-icpvt-11-93612.
Full textYamagata, Nobuki, Yuzuru Sakai, and Pedro Marcal. "Elastic-Plastic and Frature Analysis of Mobile Phones Using SPH." In ASME 2006 Pressure Vessels and Piping/ICPVT-11 Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/pvp2006-icpvt-11-93614.
Full textKruisbrink, A. Ch H., H. P. Morvan, and F. R. Pearce. "Progress in Smoothed Particle Hydrodynamics to Simulate Bearing Chambers." In ASME Turbo Expo 2014: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/gt2014-26403.
Full textVepa, Kameswara S., Diederik Van Nuffel, Wim Van Paepegem, Joris Degroote, and Jan Vierendeels. "Comparative Study of Slamming Loads on Cylindrical Structures." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49408.
Full textPiwarski, Sean A., Tyler A. Allen, Dadong Zhang, Alexander B. Sibley, Patrick Healy, Brendon M. Patierno, Bonnie L. LaCroix, et al. "Abstract PO-100: Ancestry-related variation in Sphingosine Kinase Type 1-Interacting Protein (SKIP) and Sphingosine Kinase 1 (SPHK1) and response to secondary hormonal therapy in metastatic castration-resistant prostate cancer." In Abstracts: AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; October 2-4, 2020. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp20-po-100.
Full textNguyen, Nhu, Krish P. Thiagarajan, and Matthew Cameron. "Validation Study of Smoothed Particle Hydrodynamics in Fluid and Structure Interaction and the Comparison to Boundary Element Method." In ASME 2017 36th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/omae2017-62285.
Full textReports on the topic "SphK-1"
Nelson, Jennifer, Luis Tejerina, Alexandre Bagolle, Donghyun Kang, Elisa Martinez, Pablo Orefice, Myrna Marti, et al. Digital Health For All: Social Protection and Health Division Regional Policy Dialogue Report 2022. Inter-American Development Bank, November 2022. http://dx.doi.org/10.18235/0004575.
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