Journal articles on the topic 'Sphingosine kinases'
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MYu, Pushkareva, A. Bielawska, D. Menaldiv, D. Liotta, and Y. A. Hannun. "Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids." Biochemical Journal 294, no. 3 (September 15, 1993): 699–703. http://dx.doi.org/10.1042/bj2940699.
Full textSantos, Webster L., and Kevin R. Lynch. "Drugging Sphingosine Kinases." ACS Chemical Biology 10, no. 1 (November 19, 2014): 225–33. http://dx.doi.org/10.1021/cb5008426.
Full textPorter, Hunter, Hui Qi, Nicole Prabhu, Richard Grambergs, Joel McRae, Blake Hopiavuori, and Nawajes Mandal. "Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina." International Journal of Molecular Sciences 19, no. 12 (December 5, 2018): 3885. http://dx.doi.org/10.3390/ijms19123885.
Full textMaceyka, Michael, Sheldon Milstien, and Sarah Spiegel. "Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics." Prostaglandins & Other Lipid Mediators 77, no. 1-4 (September 2005): 15–22. http://dx.doi.org/10.1016/j.prostaglandins.2004.09.010.
Full textPitson, Stuart M., Paul A. B. Moretti, Julia R. Zebol, Reza Zareie, Claudia K. Derian, Andrew L. Darrow, Jenson Qi, et al. "The Nucleotide-binding Site of Human Sphingosine Kinase 1." Journal of Biological Chemistry 277, no. 51 (October 18, 2002): 49545–53. http://dx.doi.org/10.1074/jbc.m206687200.
Full textAllende, Maria L., Teiji Sasaki, Hiromichi Kawai, Ana Olivera, Yide Mi, Gerhild van Echten-Deckert, Richard Hajdu, et al. "Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720." Journal of Biological Chemistry 279, no. 50 (September 30, 2004): 52487–92. http://dx.doi.org/10.1074/jbc.m406512200.
Full textHait, Nitai C., Carole A. Oskeritzian, Steven W. Paugh, Sheldon Milstien, and Sarah Spiegel. "Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases." Biochimica et Biophysica Acta (BBA) - Biomembranes 1758, no. 12 (December 2006): 2016–26. http://dx.doi.org/10.1016/j.bbamem.2006.08.007.
Full textBirchwood, Christine J., Julie D. Saba, Robert C. Dickson, and Kyle W. Cunningham. "Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation." Journal of Biological Chemistry 276, no. 15 (January 19, 2001): 11712–18. http://dx.doi.org/10.1074/jbc.m010221200.
Full textDing, Tiandi, HaiJiao Chen, Yan Li, Ying Li, Ying Zhi, Zhiqiang Qu, Qiang Sun, Qingqiang Yao, and Bo Liu. "Discovery of an SphK1 inhibitor: A hybrid approach involving a receptor–ligand-complex-based pharmacophore and docking-based virtual screening." Journal of Chemical Research 46, no. 2 (March 2022): 174751982210892. http://dx.doi.org/10.1177/17475198221089222.
Full textMin, Junxia, David Traynor, Andrew L. Stegner, Lei Zhang, Marie H. Hanigan, Hannah Alexander, and Stephen Alexander. "Sphingosine Kinase Regulates the Sensitivity of Dictyostelium discoideum Cells to the Anticancer Drug Cisplatin." Eukaryotic Cell 4, no. 1 (January 2005): 178–89. http://dx.doi.org/10.1128/ec.4.1.178-189.2005.
Full textMarfe, Gabriella, Giovanna Mirone, Arvind Shukla, and Carla Stefano. "Sphingosine Kinases Signalling in Carcinogenesis." Mini-Reviews in Medicinal Chemistry 15, no. 4 (March 26, 2015): 300–314. http://dx.doi.org/10.2174/1389557515666150227105415.
Full textEttmayer, Peter, Andreas Billich, Thomas Baumruker, Diana Mechtcheriakova, Heide Schmid, and Peter Nussbaumer. "Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2." Bioorganic & Medicinal Chemistry Letters 14, no. 6 (March 2004): 1555–58. http://dx.doi.org/10.1016/j.bmcl.2003.12.099.
Full textSanllehí, Pol, José-Luis Abad, Josefina Casas, and Antonio Delgado. "Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)." Chemistry and Physics of Lipids 197 (May 2016): 69–81. http://dx.doi.org/10.1016/j.chemphyslip.2015.07.007.
Full textKwong, Eric K., Xiaojiaoyang Li, Phillip B. Hylemon, and Huiping Zhou. "Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism." Current Pharmacology Reports 3, no. 4 (June 20, 2017): 176–83. http://dx.doi.org/10.1007/s40495-017-0093-2.
Full textBonica, Joseph, Cungui Mao, Lina M. Obeid, and Yusuf A. Hannun. "Transcriptional Regulation of Sphingosine Kinase 1." Cells 9, no. 11 (November 8, 2020): 2437. http://dx.doi.org/10.3390/cells9112437.
Full textPYNE, Susan, and Nigel J. PYNE. "Sphingosine 1-phosphate signalling in mammalian cells." Biochemical Journal 349, no. 2 (July 10, 2000): 385–402. http://dx.doi.org/10.1042/bj3490385.
Full textPyne, Nigel J., Melissa McNaughton, Stephanie Boomkamp, Neil MacRitchie, Cecilia Evangelisti, Alberto M. Martelli, Hui-Rong Jiang, Satvir Ubhi, and Susan Pyne. "Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation." Advances in Biological Regulation 60 (January 2016): 151–59. http://dx.doi.org/10.1016/j.jbior.2015.09.001.
Full textAdams, David R., Susan Pyne, and Nigel J. Pyne. "Sphingosine Kinases: Emerging Structure–Function Insights." Trends in Biochemical Sciences 41, no. 5 (May 2016): 395–409. http://dx.doi.org/10.1016/j.tibs.2016.02.007.
Full textBillich, Andreas, and Peter Ettmayer. "Fluorescence-based assay of sphingosine kinases." Analytical Biochemistry 326, no. 1 (March 2004): 114–19. http://dx.doi.org/10.1016/j.ab.2003.11.018.
Full textChan, Huasheng, and Stuart M. Pitson. "Post-translational regulation of sphingosine kinases." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831, no. 1 (January 2013): 147–56. http://dx.doi.org/10.1016/j.bbalip.2012.07.005.
Full textYonamine, Ikuko, Takeshi Bamba, Niraj K. Nirala, Nahid Jesmin, Teresa Kosakowska-Cholody, Kunio Nagashima, Eiichiro Fukusaki, Jairaj K. Acharya, and Usha Acharya. "Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors." Journal of Cell Biology 192, no. 4 (February 14, 2011): 557–67. http://dx.doi.org/10.1083/jcb.201004098.
Full textLabesse, Gilles, Dominique Douguet, Liliane Assairi, and Anne-Marie Gilles. "Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases." Trends in Biochemical Sciences 27, no. 6 (June 2002): 273–75. http://dx.doi.org/10.1016/s0968-0004(02)02093-5.
Full textMastrandrea, Lucy D. "Role of sphingosine kinases and sphingosine 1-phosphate in mediating adipogenesis." Journal of Diabetes Mellitus 03, no. 02 (2013): 52–61. http://dx.doi.org/10.4236/jdm.2013.32009.
Full textWong, Lingkai, Sheryl S. L. Tan, Yulin Lam, and Alirio J. Melendez. "Synthesis and Evaluation of Sphingosine Analogues as Inhibitors of Sphingosine Kinases." Journal of Medicinal Chemistry 52, no. 12 (June 25, 2009): 3618–26. http://dx.doi.org/10.1021/jm900121d.
Full textKharel, Yugesh, Thomas P. Mathews, Amanda M. Gellett, Jose L. Tomsig, Perry C. Kennedy, Morgan L. Moyer, Timothy L. Macdonald, and Kevin R. Lynch. "Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate." Biochemical Journal 440, no. 3 (November 28, 2011): 345–53. http://dx.doi.org/10.1042/bj20110817.
Full textPyne, Susan, David R. Adams, and Nigel J. Pyne. "Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances." Progress in Lipid Research 62 (April 2016): 93–106. http://dx.doi.org/10.1016/j.plipres.2016.03.001.
Full textGassowska, Magdalena, Magdalena Cieslik, Anna Wilkaniec, and Joanna B. Strosznajder. "Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells." Neurochemical Research 39, no. 4 (January 23, 2014): 645–52. http://dx.doi.org/10.1007/s11064-014-1240-3.
Full textAlemany, Regina, Chris J. van Koppen, Kerstin Danneberg, Michael ter Braak, and Dagmar Meyer zu Heringdorf. "Regulation and functional roles of sphingosine kinases." Naunyn-Schmiedeberg's Archives of Pharmacology 374, no. 5-6 (January 23, 2007): 413–28. http://dx.doi.org/10.1007/s00210-007-0132-3.
Full textIwabuchi, Kazuhisa, Hitoshi Nakayama, Ami Oizumi, Yasushi Suga, Hideoki Ogawa, and Kenji Takamori. "Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans." Mediators of Inflammation 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/120748.
Full textAyub, Maria, Hee-Kyung Jin, and Jae-sung Bae. "Novelty of Sphingolipids in the Central Nervous System Physiology and Disease: Focusing on the Sphingolipid Hypothesis of Neuroinflammation and Neurodegeneration." International Journal of Molecular Sciences 22, no. 14 (July 8, 2021): 7353. http://dx.doi.org/10.3390/ijms22147353.
Full textKirby, R. Jason, Ying Jin, Jian Fu, Jimena Cubillos, Debi Swertfeger, and Lois J. Arend. "Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney." American Journal of Physiology-Renal Physiology 296, no. 3 (March 2009): F634—F641. http://dx.doi.org/10.1152/ajprenal.90232.2008.
Full textTanaka, Yuko, Seiichi Okabe, Tetsuzo Tauchi, Yoshikazu Ito, Tomohiro Umezu, Junko H. Ohyashiki, and Kazuma Ohyashiki. "Therapeutic Potential Of Targeting Sphingosine-1-Phosuphate and Sphingosine Kinases In Multiple Myeloma." Blood 122, no. 21 (November 15, 2013): 1894. http://dx.doi.org/10.1182/blood.v122.21.1894.1894.
Full textEvangelisti, C., C. Evangelisti, F. Buontempo, A. Lonetti, E. Orsini, F. Chiarini, J. T. Barata, S. Pyne, N. J. Pyne, and A. M. Martelli. "Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies." Leukemia 30, no. 11 (July 27, 2016): 2142–51. http://dx.doi.org/10.1038/leu.2016.208.
Full textPandey, Suveg, Kelly M. Banks, Ritu Kumar, Andrew Kuo, Duancheng Wen, Timothy Hla, and Todd Evans. "Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest." STEM CELLS 38, no. 5 (January 29, 2020): 613–23. http://dx.doi.org/10.1002/stem.3145.
Full textShu, Xiaodong, Weicheng Wu, Raymond D. Mosteller, and Daniel Broek. "Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases." Molecular and Cellular Biology 22, no. 22 (November 15, 2002): 7758–68. http://dx.doi.org/10.1128/mcb.22.22.7758-7768.2002.
Full textWallington-Beddoe, Craig T., Kenneth F. Bradstock, and Linda J. Bendall. "Oncogenic properties of sphingosine kinases in haematological malignancies." British Journal of Haematology 161, no. 5 (March 25, 2013): 623–38. http://dx.doi.org/10.1111/bjh.12302.
Full textAoki, Masayo, Hiroaki Aoki, Partha Mukhopadhyay, Eriko Katsuta, and Kazuaki Takabe. "The Roles of Sphingosine Kinases in Skin Aging." Journal of Investigative Dermatology 139, no. 4 (April 2019): 951–53. http://dx.doi.org/10.1016/j.jid.2018.06.192.
Full textLee, Seulah, Joo Chan Lee, Lalita Subedi, Kyo Hee Cho, Sun Yeou Kim, Hyun-Ju Park, and Ki Hyun Kim. "Bioactive compounds from the seeds of Amomum tsaoko Crevost et Lemaire, a Chinese spice as inhibitors of sphingosine kinases, SPHK1/2." RSC Advances 9, no. 58 (2019): 33957–68. http://dx.doi.org/10.1039/c9ra07988b.
Full textKharel, Yugesh, Mithun Raje, Ming Gao, Amanda M. Gellett, Jose L. Tomsig, Kevin R. Lynch, and Webster L. Santos. "Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate." Biochemical Journal 447, no. 1 (September 12, 2012): 149–57. http://dx.doi.org/10.1042/bj20120609.
Full textWadgaonkar, Raj, Vipul Patel, Natalia Grinkina, Carol Romano, Jing Liu, Yutong Zhao, Saad Sammani, Joe G. N. Garcia, and Viswanathan Natarajan. "Differential regulation of sphingosine kinases 1 and 2 in lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 296, no. 4 (April 2009): L603—L613. http://dx.doi.org/10.1152/ajplung.90357.2008.
Full textMiller, Anna V., Sergio E. Alvarez, Sarah Spiegel, and Deborah A. Lebman. "Sphingosine Kinases and Sphingosine-1-Phosphate Are Critical for Transforming Growth Factor β-Induced Extracellular Signal-Regulated Kinase 1 and 2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells." Molecular and Cellular Biology 28, no. 12 (April 21, 2008): 4142–51. http://dx.doi.org/10.1128/mcb.01465-07.
Full textMagli, Elisa, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Irene Saccone, Vincenzo Santagada, Giuseppe Caliendo, and Beatrice Severino. "Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments." Current Pharmaceutical Design 25, no. 9 (July 9, 2019): 956–68. http://dx.doi.org/10.2174/1381612825666190404115424.
Full textGao, Peng, Yuri K. Peterson, Ryan A. Smith, and Charles D. Smith. "Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases." PLoS ONE 7, no. 9 (September 10, 2012): e44543. http://dx.doi.org/10.1371/journal.pone.0044543.
Full textBillich, Andreas, Frederic Bornancin, Piroska Dévay, Diana Mechtcheriakova, Nicole Urtz, and Thomas Baumruker. "Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases." Journal of Biological Chemistry 278, no. 48 (September 16, 2003): 47408–15. http://dx.doi.org/10.1074/jbc.m307687200.
Full textMahoney, James A., and Ronald L. Schnaar. "Multivalent ganglioside and sphingosine conjugates modulate myelin protein kinases." Biochimica et Biophysica Acta (BBA) - Biomembranes 1328, no. 1 (August 1997): 30–40. http://dx.doi.org/10.1016/s0005-2736(97)00070-9.
Full textBRYAN, L. "Regulation and functions of sphingosine kinases in the brain." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1781, no. 9 (September 2008): 459–66. http://dx.doi.org/10.1016/j.bbalip.2008.04.008.
Full textMizugishi, Kiyomi, Tadashi Yamashita, Ana Olivera, Georgina F. Miller, Sarah Spiegel, and Richard L. Proia. "Essential Role for Sphingosine Kinases in Neural and Vascular Development." Molecular and Cellular Biology 25, no. 24 (December 15, 2005): 11113–21. http://dx.doi.org/10.1128/mcb.25.24.11113-11121.2005.
Full textBrindley, David N., Abdelkarim Abousalham, Yutaka Kikuchi, Chuen-Neu Wang, and David W. Waggoner. ""Cross talk" between the bioactive glycerolipids and sphingolipids in signal transduction." Biochemistry and Cell Biology 74, no. 4 (July 1, 1996): 469–76. http://dx.doi.org/10.1139/o96-051.
Full textLynch, Kevin R. "Building a better sphingosine kinase-1 inhibitor." Biochemical Journal 444, no. 1 (April 26, 2012): e1-e2. http://dx.doi.org/10.1042/bj20120567.
Full textRaeder, Evelin M. B., Pamela J. Mansfield, Vania Hinkovska-Galcheva, Lars Kjeldsen, James A. Shayman, and Laurence A. Boxer. "Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation." Blood 93, no. 2 (January 15, 1999): 686–93. http://dx.doi.org/10.1182/blood.v93.2.686.
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