Academic literature on the topic 'Sphingosine kinases'
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Journal articles on the topic "Sphingosine kinases"
MYu, Pushkareva, A. Bielawska, D. Menaldiv, D. Liotta, and Y. A. Hannun. "Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids." Biochemical Journal 294, no. 3 (September 15, 1993): 699–703. http://dx.doi.org/10.1042/bj2940699.
Full textSantos, Webster L., and Kevin R. Lynch. "Drugging Sphingosine Kinases." ACS Chemical Biology 10, no. 1 (November 19, 2014): 225–33. http://dx.doi.org/10.1021/cb5008426.
Full textPorter, Hunter, Hui Qi, Nicole Prabhu, Richard Grambergs, Joel McRae, Blake Hopiavuori, and Nawajes Mandal. "Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina." International Journal of Molecular Sciences 19, no. 12 (December 5, 2018): 3885. http://dx.doi.org/10.3390/ijms19123885.
Full textMaceyka, Michael, Sheldon Milstien, and Sarah Spiegel. "Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics." Prostaglandins & Other Lipid Mediators 77, no. 1-4 (September 2005): 15–22. http://dx.doi.org/10.1016/j.prostaglandins.2004.09.010.
Full textPitson, Stuart M., Paul A. B. Moretti, Julia R. Zebol, Reza Zareie, Claudia K. Derian, Andrew L. Darrow, Jenson Qi, et al. "The Nucleotide-binding Site of Human Sphingosine Kinase 1." Journal of Biological Chemistry 277, no. 51 (October 18, 2002): 49545–53. http://dx.doi.org/10.1074/jbc.m206687200.
Full textAllende, Maria L., Teiji Sasaki, Hiromichi Kawai, Ana Olivera, Yide Mi, Gerhild van Echten-Deckert, Richard Hajdu, et al. "Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720." Journal of Biological Chemistry 279, no. 50 (September 30, 2004): 52487–92. http://dx.doi.org/10.1074/jbc.m406512200.
Full textHait, Nitai C., Carole A. Oskeritzian, Steven W. Paugh, Sheldon Milstien, and Sarah Spiegel. "Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases." Biochimica et Biophysica Acta (BBA) - Biomembranes 1758, no. 12 (December 2006): 2016–26. http://dx.doi.org/10.1016/j.bbamem.2006.08.007.
Full textBirchwood, Christine J., Julie D. Saba, Robert C. Dickson, and Kyle W. Cunningham. "Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation." Journal of Biological Chemistry 276, no. 15 (January 19, 2001): 11712–18. http://dx.doi.org/10.1074/jbc.m010221200.
Full textDing, Tiandi, HaiJiao Chen, Yan Li, Ying Li, Ying Zhi, Zhiqiang Qu, Qiang Sun, Qingqiang Yao, and Bo Liu. "Discovery of an SphK1 inhibitor: A hybrid approach involving a receptor–ligand-complex-based pharmacophore and docking-based virtual screening." Journal of Chemical Research 46, no. 2 (March 2022): 174751982210892. http://dx.doi.org/10.1177/17475198221089222.
Full textMin, Junxia, David Traynor, Andrew L. Stegner, Lei Zhang, Marie H. Hanigan, Hannah Alexander, and Stephen Alexander. "Sphingosine Kinase Regulates the Sensitivity of Dictyostelium discoideum Cells to the Anticancer Drug Cisplatin." Eukaryotic Cell 4, no. 1 (January 2005): 178–89. http://dx.doi.org/10.1128/ec.4.1.178-189.2005.
Full textDissertations / Theses on the topic "Sphingosine kinases"
Megidish, Tamar. "Sphingosine as second messenger, sphingosine dependent protein kinases and their substrates /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9285.
Full textTonelli, Francesca R. "Sphingosine kinases : evaluation of therapeutic potential using prostate cancer cell models." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18199.
Full textBonhoure, Elisabeth. "Rôle de la sphingosine kinase-1 dans la réponse des cellules tumorales à la chimiothérapie." Toulouse 3, 2007. http://www.theses.fr/2007TOU30114.
Full textDayon, Audrey. "Rôle de la sphingosine kinase-1 dans la survie et la progression des cellules tumorales prostatiques LNCaP vers l'androgéno-indépendance." Toulouse 3, 2008. http://thesesups.ups-tlse.fr/307/.
Full textAs prostate cancer cell proliferation is regulated by androgens, strategies aimed at reducing the production of androgens and/or effects are the standard of care in the management of patients with recurrent or advanced disease. Unfortunately all patients become resistant to hormonal manipulation and it is not clear how prostate cancer cells make the transition from being androgen-dependent to being androgen-independent after hormone ablation therapy. We have shown in the Lab that the oncogenic sphingosine kinase (SK) is overexpressed in tumor samples from prostate cancer patients (as compared with normal counterparts). We provide the first evidence that androgen privation induces a differential effect on SK activity in the hormono-sensitive LNCaP prostate cancer cell model. Short-term androgen removal induced a rapid and transient SK inhibition in vitro and in vivo in an orthotopically LNCaP model established in SCID mice. Conversely, long-term removal of androgen resulted in a progressive increase in SK expression and activity throughout the progression to androgen-independence state, which was characterized by the acquisition of a neuroendocrine (NE)-like cell phenotype. Fascinatingly, the reversability of the NE phenotype by exposure to normal medium was linked with a pronounced inhibition of SK activity. These results suggest that SK activation upon chronic androgen privation may serve as a compensatory mechanism allowing prostate cancer cells to survive in androgen-depleted environment, giving support to its inhibition as a potential therapeutic strategy to delay/prevent the transition to androgen-independent prostate cancer
Niaudet, Colin. "Caractérisation et modulation des évènements initiaux contrôlant la mort radioinduite de l'endothélium microvasculaire." Nantes, 2009. https://archive.bu.univ-nantes.fr/pollux/show/show?id=34ca7579-91aa-46a5-bc5a-1291a772a1b6.
Full textHigh dose of ionizing radiation drives microvascular compartment to apoptosis, which controls the whole tissue damaging-process, through the acid sphingomyelinase (ASM)/ceramide pathway. We adressed the connection between ASMase-induced apoptosis and the well-known capacity of ceramide to induce rafts microdomains coalescence into large platforms. Concomitantly to membrane remodeling, irradiation activated p38 death pathway and its blockade partially protected endothelial cells from radiation-induced death. Finally, disorganization of rafts by cholesterol-depletor hindered the p38 activation and the subsequent death-induced microvascular cells. These results suggest a specific membrane controled death mechanism in irradiated endothelial cells, where rafts coalescence leads to p38 activation and apoptosis. We then used sphingosine-1-phosphate (S1P), a ceramide antagonist, to modulate this early wave of radioinduced death in endothelium. We validated the pharmacological use of systemic S1P to restrain acute organ failure in response to severe stress: S1P injection abolished endothelial cells collapse and therefore prevented 15 Gy-induced gastrointestinal syndrome, as well as LPS-induced septic shock, another syndrome driven by microvascular apoptosis. This protection from S1P toward endothelium showed a dual specificity: related sphingolipids failed to offer the same protective effects, and this protection affected only endothelial cells as compared to intestinal epithelial cells or lymphocytes. S1P-induced protective effect is mediated through G-protein coupled receptor then the prosurvival protein Akt, as inhibition of both pathways suppresses the S1P action in vitro and in vivo
Gomez-Brouchet, Anne. "Rôle de la Sphingosine Kinase 1 (SphK1) dans la régulation de la survie des cellules de neuroblastome exposées au peptide Béta-amyloïde." Toulouse 3, 2007. http://www.theses.fr/2007TOU30251.
Full textAlzheimer disease (AD) is a critical problem of public health in the industrialized countries. AD affects 24. 3 million individuals in the world. In France, the number of AD patients represents 5 % of the population over 65 years-old (20 % of people over 85 years-old). Important progress have been made during the last ten years: Mutations were characterized, as well as genetic or environmental risk factors. A better analysis of the two elementary lesions of AD in their distribution and molecular characterization has allowed a better comprehension of the disease. Thus, the description of a dysfunction of proteins APP (Amyloid Precursor Protein) and Tau in sporadic and familial AD has led to therapeutic experiments and tests on cellular or animal models with promising results. Even though the diagnosis of AD still remains related to the neuropathology, it is evoked more precociously due to the progress in neuropsychological evaluation and imaging procedures. The advances in the comprehension of the disease mechanisms should make possible the discovery of new therapeutic targets. .
Thompson, Dawn. "Sphingosine kinase and sphingosine-1 phosphate phosphatase : molecular tools to investigate the role of sphingosine-1-phosphate." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401320.
Full textCongdon, Molly D. "Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82129.
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Ng, Carl Khee-Yew. "Drought induced guard cell signal transduction involves sphingosine 1 phosphate." Thesis, Lancaster University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250627.
Full textAndrieu, Guillaume. "Rôle de la voie sphingosine kinase/sphingosine 1-phosphate dans le contrôle de la division cellulaire." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2605/.
Full textCell division is a crucial process for genome maintenance. In cancer, numerous regulators of mitosis are mutated or altered, impeding the quality of chromosome segregation. Tumors exhibit a high chromosomal instability and are frequently aneuploid. These hallmarks promote tumor initiation and progression but are also associated with poor prognosis and therapeutic resistance. The sphingosine kinases/sphingosine 1-phosphate (SphKs/S1P) pathway is a key regulator of several fundamental biological processes including cell proliferation, survival, apoptosis, migration or inflammatory response. Numerous studies have shown that the up-regulation of the SphKs/S1P pathway promotes tumor initiation and progression, invasion, metastasis and resistance to anticancer therapies. We are interested in the role of the SphKs/S1P pathway in cell division regulation. Our data indicate for the first time that SphKs regulate mitotic progression trough S1P production and the interaction with its G protein-coupled receptor S1P5. Furthermore, we showed that the up-regulation of the SphKs/S1P pathway impairs chromosome segregation. Finally, our recent data suggest that the SphKs/S1P pathway may be involved in the acquisition of resistance to mitotic chemotherapeutic agents. Overall, we have identified the SphKs/S1P/S1P5 pathway as a new genuine regulator of mitosis. We give support to the understanding of the implication of the SphKs/S1P pathway in tumoral progression and strengthen its interest as anti-cancer therapeutic targets
Book chapters on the topic "Sphingosine kinases"
Pyne, Susan, David R. Adams, and Nigel J. Pyne. "Sphingosine Kinases as Druggable Targets." In Lipid Signaling in Human Diseases, 49–76. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/164_2018_96.
Full textPitman, Melissa R., Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson. "Sphingosine Kinases: Biochemistry, Regulation, and Roles." In Lysophospholipid Receptors, 153–83. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118531426.ch9.
Full textMeng, H., and V. M. Lee. "Widespread Expression of Sphingosine Kinases and Sphingosine 1-Phosphate (S1P) Lyase Suggests Diverse Functions in the Vertebrate Nervous System." In Lysophospholipid Receptors, 419–32. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118531426.ch19.
Full textOlivera, Ana, and Sarah Spiegel. "Sphingosine Kinase." In Phospholipid Signaling Protocols, 233–42. Totowa, NJ: Humana Press, 1998. http://dx.doi.org/10.1385/0-89603-491-7:233.
Full textNeubauer, Heidi, and Stuart Pitson. "Sphingosine Kinase 2 (SPHK2)." In Encyclopedia of Signaling Molecules, 5119–28. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101836.
Full textNeubauer, Heidi, and Stuart Pitson. "Sphingosine Kinase 2 (SPHK2)." In Encyclopedia of Signaling Molecules, 1–9. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101836-1.
Full textMaceyka, Michael, Sergio E. Alvarez, Sheldon Milstien, and Sarah Spiegel. "Activation of Sphingosine Kinase 1." In Sphingolipid Biology, 197–206. Tokyo: Springer Japan, 2006. http://dx.doi.org/10.1007/4-431-34200-1_14.
Full textGandy, K. Alexa Orr, and Lina M. Obeid. "Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway." In Sphingolipids in Disease, 275–303. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1511-4_14.
Full textBrizuela, Leyre, and Olivier Cuvillier. "Biochemical Methods for Quantifying Sphingolipids: Ceramide, Sphingosine, Sphingosine Kinase-1 Activity, and Sphingosine-1-Phosphate." In Methods in Molecular Biology, 1–20. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-800-9_1.
Full textSelvam, Shanmugam Panneer, and Besim Ogretmen. "Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance." In Sphingolipids in Disease, 3–27. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1511-4_1.
Full textConference papers on the topic "Sphingosine kinases"
Gairhe, Salina, Masahiko Oka, and Ivan McMurtry. "Pulmonary Arterial Expression Of Sphingosine Kinases Is Markedly Increased In Pulmonary Arterial Hypertension." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4752.
Full textGairhe, Salina, Abdallah Alzoubi, Michie Toba, Masahiko Oka, and Ivan McMurtry. "Effect Of Dehydroepiandrosterone On The Expression Of Sphingosine Kinases In Pulmonary Arteries Of Sugen Hypoxia Rat Model Of Pulmonary Arterial Hypertension." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4777.
Full textGhent, Matthew V., Youngleem Kim, Ana Jakimenko, and C. Patrick Reynolds. "Abstract 5262: Resistance to fenretinide in neuroblastoma is associated with increased expression of sphingosine kinase and sphingosine-1-phosphate receptors and targeting sphingosine kinase reverses resistance." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5262.
Full textTimmons, Sheila, and Jack Hawiger. "REGULATION OF PLATELET RECEPTORS FOR FIBRINOGEN AND VON WILLEBRAND FACTOR BY PROTEIN KINASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644674.
Full textRoviezzo, Fiorentina, Giovanna De Cunto, Maria Antonietta Riemma, Ida Cerqua, Monica Luccattelli, and Giuseppe Cirino. "Sphingosine kinase/sphingosine-1-phosphate pathway contributes to airway hyper-responsiveness in cigarette smoke exposed mice." In Abstracts from the 17th ERS Lung Science Conference: ‘Mechanisms of Acute Exacerbation of Respiratory Disease’. European Respiratory Society, 2019. http://dx.doi.org/10.1183/23120541.lungscienceconference-2019.pp116.
Full textGao, Peng, Yan Zhuang, and Charles D. Smith. "Abstract 838A: Characterization of sphingosine kinase isoenzyme selective inhibitors." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-838a.
Full textGutbier, Birgitt, Stefanie M. Schoenrock, Rainer Haberberger, Andreas C. Hocke, Stefan Hippenstiel, Anja Luth, Burkhard Kleuser, et al. "Sphingosine Kinase-1 And Sphingosine-1-Phosphate Promote The Development Of Acute Lung Injury In Pneumoccocal Pneumonia." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1040.
Full textGorshkova, I., E. Berdyshev, P. Usatyuk, S. Kalari, Y. Zhao, NG Pyne, S. Pyne, and V. Natarajan. "Involvement of Intracellular Sphingosine-1-Phosphate in Lung Endothelial Cell Motility: Role of Sphingosine Kinase 1, Sphingosine-1-Phosphate Lyase and Serine Palmitoyl Transferase." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6121.
Full textKawamori, Toshihiko, Hideki Furuya, Masayuki Wada, Jacek Bielawski, Yusuf A. Hannun, and Lina M. Obeid. "Abstract B80: Role for sphingosine kinase 1 in colon carcinogenesis." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Dec 6–9, 2009; Houston, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1940-6207.prev-09-b80.
Full textWadgaonkar, S., O. Ramadan, N. Grinkina, S. Puttaswamy, and R. Wadgaonkar. "Functional Interaction of Lyn-Sphingosine Kinase in Endothelial Cell Microdomains." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6118.
Full textReports on the topic "Sphingosine kinases"
Maceyka, Michael W. Regulation of Sphingosine Kinase in Prostate Cancer Cells. Fort Belvoir, VA: Defense Technical Information Center, March 2004. http://dx.doi.org/10.21236/ada427918.
Full textMaceyka, Michael W. Regulation of Sphingosine Kinase in Prostate Cancer Cells. Fort Belvoir, VA: Defense Technical Information Center, March 2003. http://dx.doi.org/10.21236/ada420163.
Full textHobson, John P. Regulation of Cell Survival in Human Breast Cancer Cells by Sphingosine Kinase. Fort Belvoir, VA: Defense Technical Information Center, January 2001. http://dx.doi.org/10.21236/ada393851.
Full textSankala, Heidi, and Sarah Spiegel. The Role of Sphingosine Kinase 2 in Apoptosis of Human Breast Cancer Cells. Fort Belvoir, VA: Defense Technical Information Center, May 2006. http://dx.doi.org/10.21236/ada455788.
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