Journal articles on the topic 'Sphingosine kinase activator molecule'
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Brindley, David N., Abdelkarim Abousalham, Yutaka Kikuchi, Chuen-Neu Wang, and David W. Waggoner. ""Cross talk" between the bioactive glycerolipids and sphingolipids in signal transduction." Biochemistry and Cell Biology 74, no. 4 (July 1, 1996): 469–76. http://dx.doi.org/10.1139/o96-051.
Full textAllende, Maria L., Teiji Sasaki, Hiromichi Kawai, Ana Olivera, Yide Mi, Gerhild van Echten-Deckert, Richard Hajdu, et al. "Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720." Journal of Biological Chemistry 279, no. 50 (September 30, 2004): 52487–92. http://dx.doi.org/10.1074/jbc.m406512200.
Full textUrtz, Nicole, Ana Olivera, Elisa Bofill-Cardona, Robert Csonga, Andreas Billich, Diana Mechtcheriakova, Frederic Bornancin, Max Woisetschläger, Juan Rivera, and Thomas Baumruker. "Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase." Molecular and Cellular Biology 24, no. 19 (October 1, 2004): 8765–77. http://dx.doi.org/10.1128/mcb.24.19.8765-8777.2004.
Full textDygas, A., M. Sidorko, M. Bobeszko, and J. Barańska. "Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells." Acta Biochimica Polonica 46, no. 1 (March 31, 1999): 99–106. http://dx.doi.org/10.18388/abp.1999_4187.
Full textEl-Shewy, Hesham M., Souzan A. Abdel-Samie, Abdelmohsen M. Al Qalam, Mi-Hye Lee, Kazuyuki Kitatani, Viviana Anelli, Ayad A. Jaffa, Lina M. Obeid, and Louis M. Luttrell. "Phospholipase C and Protein Kinase C-β 2 Mediate Insulin-Like Growth Factor II-Dependent Sphingosine Kinase 1 Activation." Molecular Endocrinology 25, no. 12 (December 1, 2011): 2144–56. http://dx.doi.org/10.1210/me.2011-0101.
Full textPYNE, Susan, and Nigel J. PYNE. "Sphingosine 1-phosphate signalling in mammalian cells." Biochemical Journal 349, no. 2 (July 10, 2000): 385–402. http://dx.doi.org/10.1042/bj3490385.
Full textDesai, N. N., R. O. Carlson, M. E. Mattie, A. Olivera, N. E. Buckley, T. Seki, G. Brooker, and S. Spiegel. "Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts." Journal of Cell Biology 121, no. 6 (June 15, 1993): 1385–95. http://dx.doi.org/10.1083/jcb.121.6.1385.
Full textKing, Charles C., Frank T. Zenke, Philip E. Dawson, Erica M. Dutil, Alexandra C. Newton, Brian A. Hemmings, and Gary M. Bokoch. "Sphingosine Is a Novel Activator of 3-Phosphoinositide-dependent Kinase 1." Journal of Biological Chemistry 275, no. 24 (March 29, 2000): 18108–13. http://dx.doi.org/10.1074/jbc.m909663199.
Full textSpertini, F., A. V. Wang, T. Chatila, and R. S. Geha. "Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells." Journal of Immunology 153, no. 4 (August 15, 1994): 1593–602. http://dx.doi.org/10.4049/jimmunol.153.4.1593.
Full textMourad, W., R. S. Geha, and T. Chatila. "Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion." Journal of Experimental Medicine 172, no. 5 (November 1, 1990): 1513–16. http://dx.doi.org/10.1084/jem.172.5.1513.
Full textAoki, Masayo, Hiroaki Aoki, Partha Mukhopadhyay, Takuya Tsuge, Hirofumi Yamamoto, Noriko M. Matsumoto, Eri Toyohara, Yuri Okubo, Rei Ogawa, and Kazuaki Takabe. "Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation." International Journal of Molecular Sciences 20, no. 14 (July 10, 2019): 3381. http://dx.doi.org/10.3390/ijms20143381.
Full textLimaye, Vidya, Xiaochun Li, Chris Hahn, Pu Xia, Michael C. Berndt, Mathew A. Vadas, and Jennifer R. Gamble. "Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1–dependent activation of PI-3K/Akt and regulation of Bcl-2 family members." Blood 105, no. 8 (April 15, 2005): 3169–77. http://dx.doi.org/10.1182/blood-2004-02-0452.
Full textShamshiddinova, Maftuna, Shokhid Gulyamov, Hee-Jung Kim, Seo-Hyeon Jung, Dong-Jae Baek, and Yong-Moon Lee. "A Dansyl-Modified Sphingosine Kinase Inhibitor DPF-543 Enhanced De Novo Ceramide Generation." International Journal of Molecular Sciences 22, no. 17 (August 25, 2021): 9190. http://dx.doi.org/10.3390/ijms22179190.
Full textHe, H., AC Herington, and P. Roupas. "Effect of protein kinase C modulation on gonadotrophin-induced granulosa cell steroidogenesis." Reproduction, Fertility and Development 7, no. 1 (1995): 83. http://dx.doi.org/10.1071/rd9950083.
Full textNewton, Jason, Elisa N. D. Palladino, Cynthia Weigel, Michael Maceyka, Markus H. Gräler, Can E. Senkal, Ricardo D. Enriz, et al. "Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation." Journal of Biological Chemistry 295, no. 27 (May 8, 2020): 9121–33. http://dx.doi.org/10.1074/jbc.ra120.012659.
Full textMelendez, Alirio J., Manikandan Jayapal, and Peter Natesan Pushparaj. "SIRNA KNOCKDOWN OF SPHK1 PROTECTS MICE FROM IGE-MEDIATED ANAPHYLAXIS (37.6)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S19. http://dx.doi.org/10.4049/jimmunol.178.supp.37.6.
Full textZhang, Jianqing, Norman Honbo, Edward J. Goetzl, Kanu Chatterjee, Joel S. Karliner, and Mary O. Gray. "Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 5 (November 2007): H3150—H3158. http://dx.doi.org/10.1152/ajpheart.00587.2006.
Full textPark, Hwa-young, Jong-Kyung Youm, Mi Jung Kwon, Byeong Deog Park, Seung Hun Lee, and Eung Ho Choi. "K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin." Experimental Dermatology 17, no. 10 (October 2008): 829–36. http://dx.doi.org/10.1111/j.1600-0625.2008.00708.x.
Full textGiusto, Kiersten, and Charles R. Ashby. "Investigating the Et-1/SphK/S1P Pathway as a Novel Approach for the Prevention of Inflammation-Induced Preterm Birth." Current Pharmaceutical Design 24, no. 9 (May 18, 2018): 983–88. http://dx.doi.org/10.2174/1381612824666180130122739.
Full textKleger, Alexander, Stefan Liebau, Qiong Lin, Götz von Wichert, and Thomas Seufferlein. "The Impact of Bioactive Lipids on Cardiovascular Development." Stem Cells International 2011 (2011): 1–13. http://dx.doi.org/10.4061/2011/916180.
Full textCaruso-Neves, C., J. R. Meyer-Fernandes, and A. G. Lopes. "Osmotic Modulation of the Ouabain-Sensitive (Na++K+)ATPase from Malpighian Tubules of Rhodnius prolixus." Zeitschrift für Naturforschung C 53, no. 9-10 (October 1, 1998): 911–17. http://dx.doi.org/10.1515/znc-1998-9-1021.
Full textKatkade, Vaibhav, Abigail A. Soyombo, Irma Isordia-Salas, Harlan N. Bradford, John P. Gaughan, Robert W. Colman, and Tracee S. Panetti. "Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt." Thrombosis and Haemostasis 94, no. 09 (2005): 606–14. http://dx.doi.org/10.1160/th04-12-0834.
Full textYoum, Jong-Kyung, Hae Jo, Jeong Hee Hong, Dong Min Shin, Mi Jung Kwon, Se Kyoo Jeong, Byeong Deog Park, Eung Ho Choi, and Seung Hun Lee. "K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling." Journal of Dermatological Science 51, no. 2 (August 2008): 89–102. http://dx.doi.org/10.1016/j.jdermsci.2008.03.002.
Full textSun, Kaiqi, Yujin Zhang, Mikhail Bogdanov, William Dowhan, Modupe Idowu, Harinder S. Juneja, Michael R. Blackburn, Rodney E. Kellems, and Yang Xia. "Elevated Adenosine Signaling Via Adenosine A2B Receptor Induces Normal and Sickle Erythrocyte Sphingosine Kinase 1 Activity." Blood 124, no. 21 (December 6, 2014): 4067. http://dx.doi.org/10.1182/blood.v124.21.4067.4067.
Full textBianco, Roberto, Roberta Rosa, Lucia Nappi, Luigi Formisano, Vincenzo Damiano, Claudia d'Amato, Ana Paula de Maio, et al. "Role of sphingosine kinase 1 (SphK1) on cetuximab resistance in colorectal cancer models." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e13509-e13509. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13509.
Full textTokuyama, Michio, and Tomotaka Mabuchi. "New Treatment Addressing the Pathogenesis of Psoriasis." International Journal of Molecular Sciences 21, no. 20 (October 11, 2020): 7488. http://dx.doi.org/10.3390/ijms21207488.
Full textDowney, G. P., C. K. Chan, P. Lea, A. Takai, and S. Grinstein. "Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C." Journal of Cell Biology 116, no. 3 (February 1, 1992): 695–706. http://dx.doi.org/10.1083/jcb.116.3.695.
Full textLi, Donghui, Aarti N. Urs, Jeremy Allegood, Adam Leon, Alfred H. Merrill, and Marion B. Sewer. "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17." Molecular and Cellular Biology 27, no. 19 (July 30, 2007): 6669–85. http://dx.doi.org/10.1128/mcb.00355-07.
Full textQin, Zhiqiang, Lu Dai, Karlie Plaisance-Bonstaff, Can Senkal, Wenxue Wang, Thomas M. Reske, Luis Del Valle, et al. "Targeting Sphingosine Kinase Induces Apoptosis and Regression Of Virus-Associated Lymphoma In Vivo." Blood 122, no. 21 (November 15, 2013): 4414. http://dx.doi.org/10.1182/blood.v122.21.4414.4414.
Full textAn, Ningfei, Yeong-Bin Im, Peng Gao, Luciano J. Costa, Robert K. Stuart, Charles Smith, and Yubin Kang. "Potential Use of Sphingosine Kinase-2 Selective Inhibitors for the Treatment of Multiple Myeloma." Blood 118, no. 21 (November 18, 2011): 5105. http://dx.doi.org/10.1182/blood.v118.21.5105.5105.
Full textRosell, Rafael, Imane Chaib, Xueting Cai, David Llige, Mariacarmela Santarpia, Eloisa Jantus-Lewintre, Martyna Filipska, et al. "Osimertinib and dihydroartemisinin: A novel drug combination targeting head and neck squamous cell carcinoma." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e17526-e17526. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17526.
Full textBeyer, Sandra, Stephanie Schwalm, Josef Pfeilschifter, and Andrea Huwiler. "Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis." Cellular Physiology and Biochemistry 47, no. 6 (2018): 2522–33. http://dx.doi.org/10.1159/000491625.
Full textGrbčić, Petra, Thomas O. Eichmann, Sandra Kraljević Pavelić, and Mirela Sedić. "The Sphingosine Kinase 2 Inhibitor ABC294640 Restores the Sensitivity of BRAFV600E Mutant Colon Cancer Cells to Vemurafenib by Reducing AKT-Mediated Expression of Nucleophosmin and Translationally-Controlled Tumour Protein." International Journal of Molecular Sciences 22, no. 19 (October 5, 2021): 10767. http://dx.doi.org/10.3390/ijms221910767.
Full textPaugh, Barbara S., Steven W. Paugh, Lauren Bryan, Dmitri Kapitonov, Katarzyna M. Wilczynska, Sunita M. Gopalan, Hanna Rokita, Sheldon Milstien, Sarah Spiegel, and Tomasz Kordula. "EGF regulates plasminogen activator inhibitor‐1 (PAI‐1) by a pathway involving c‐Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells." FASEB Journal 22, no. 2 (September 12, 2007): 455–65. http://dx.doi.org/10.1096/fj.07-8276com.
Full textPrieschl, Eva E., Robert Csonga, Veronica Novotny, Gary E. Kikuchi, and Thomas Baumruker. "The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering." Journal of Experimental Medicine 190, no. 1 (July 1, 1999): 1–8. http://dx.doi.org/10.1084/jem.190.1.1.
Full textOaks, Joshua, Paolo Neviani, A. Mukhopadhyay, Ramasamy Santhanam, Y. Ma, Charlene Mao, Guido Marcucci, et al. "FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor." Blood 114, no. 22 (November 20, 2009): 3259. http://dx.doi.org/10.1182/blood.v114.22.3259.3259.
Full textLee, Kiho, Iliana Escobar, Yeeun Jang, Wooseong Kim, Frederick M. Ausubel, and Eleftherios Mylonakis. "In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria." International Journal of Molecular Sciences 21, no. 21 (October 22, 2020): 7813. http://dx.doi.org/10.3390/ijms21217813.
Full textdela Paz, Nathaniel G., Benoît Melchior, and John A. Frangos. "Shear stress induces Gαq/11 activation independently of G protein-coupled receptor activation in endothelial cells." American Journal of Physiology-Cell Physiology 312, no. 4 (April 1, 2017): C428—C437. http://dx.doi.org/10.1152/ajpcell.00148.2016.
Full textBandhuvula, Padmavathi, Norman Honbo, Guan-Ying Wang, Zhu-Qiu Jin, Henrik Fyrst, Meng Zhang, Alexander D. Borowsky, Lisa Dillard, Joel S. Karliner, and Julie D. Saba. "S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart." American Journal of Physiology-Heart and Circulatory Physiology 300, no. 5 (May 2011): H1753—H1761. http://dx.doi.org/10.1152/ajpheart.00946.2010.
Full textBirchwood, Christine J., Julie D. Saba, Robert C. Dickson, and Kyle W. Cunningham. "Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation." Journal of Biological Chemistry 276, no. 15 (January 19, 2001): 11712–18. http://dx.doi.org/10.1074/jbc.m010221200.
Full textMiller, Anna V., Sergio E. Alvarez, Sarah Spiegel, and Deborah A. Lebman. "Sphingosine Kinases and Sphingosine-1-Phosphate Are Critical for Transforming Growth Factor β-Induced Extracellular Signal-Regulated Kinase 1 and 2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells." Molecular and Cellular Biology 28, no. 12 (April 21, 2008): 4142–51. http://dx.doi.org/10.1128/mcb.01465-07.
Full textShu, Xiaodong, Weicheng Wu, Raymond D. Mosteller, and Daniel Broek. "Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases." Molecular and Cellular Biology 22, no. 22 (November 15, 2002): 7758–68. http://dx.doi.org/10.1128/mcb.22.22.7758-7768.2002.
Full textWalker, Christopher, Joshua J. Oaks, Paolo Neviani, Jason G. Harb, Ramasamy Santhanam, Y. Ma, Guido Marcucci, et al. "PP2A Activating Drugs (PAD): Anti-Leukemic and Non-Toxic Activity of Two Novel and Non-Immunosuppressive FTY720 Derivatives." Blood 116, no. 21 (November 19, 2010): 2901. http://dx.doi.org/10.1182/blood.v116.21.2901.2901.
Full textIgarashi, Junsuke, Sylvie G. Bernier, and Thomas Michel. "Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase." Journal of Biological Chemistry 276, no. 15 (January 17, 2001): 12420–26. http://dx.doi.org/10.1074/jbc.m008375200.
Full textAdebiyi, Morayo G., Yujin Zhang, Kaiqi Sun, Xia Hu, Shusuan Zhao, Hongyu Wu, Jacob Couturier, Dorothy L. Lewis, Edgar T. Walters, and Yang Xia. "Sphingosine-1-Phosphate (S1P) Signaling through S1P Receptor 1 (S1PR1) in Macrophage Contributes to Pain in Sickle Cell Disease." Blood 128, no. 22 (December 2, 2016): 2476. http://dx.doi.org/10.1182/blood.v128.22.2476.2476.
Full textWu, Weicheng, Raymond D. Mosteller, and Daniel Broek. "Sphingosine Kinase Protects Lipopolysaccharide-Activated Macrophages from Apoptosis." Molecular and Cellular Biology 24, no. 17 (September 1, 2004): 7359–69. http://dx.doi.org/10.1128/mcb.24.17.7359-7369.2004.
Full textSukocheva, Olga A., Lijun Wang, Nathaniel Albanese, Stuart M. Pitson, Mathew A. Vadas, and Pu Xia. "Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells." Molecular Endocrinology 17, no. 10 (October 1, 2003): 2002–12. http://dx.doi.org/10.1210/me.2003-0119.
Full textAdada, Mohamad M., K. Alexa Orr-Gandy, Ashley J. Snider, Daniel Canals, Yusuf A. Hannun, Lina M. Obeid, and Christopher J. Clarke. "Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation." Journal of Biological Chemistry 288, no. 38 (August 9, 2013): 27667–79. http://dx.doi.org/10.1074/jbc.m113.489443.
Full textPitson, Stuart M., Paul A. B. Moretti, Julia R. Zebol, Pu Xia, Jennifer R. Gamble, Mathew A. Vadas, Richard J. D'Andrea, and Binks W. Wattenberg. "Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation." Journal of Biological Chemistry 275, no. 43 (August 15, 2000): 33945–50. http://dx.doi.org/10.1074/jbc.m006176200.
Full textHanna, Atef N., Luc G. Berthiaume, Yutaka Kikuchi, David Begg, Sylvain Bourgoin, and David N. Brindley. "Tumor Necrosis Factor-α Induces Stress Fiber Formation through Ceramide Production: Role of Sphingosine Kinase." Molecular Biology of the Cell 12, no. 11 (November 2001): 3618–30. http://dx.doi.org/10.1091/mbc.12.11.3618.
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