Relevant bibliographies by topics / Spermatogenesis

Academic literature on the topic 'Spermatogenesis'

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Published: 4 June 2021
Last updated: 7 September 2024

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Journal articles on the topic "Spermatogenesis"

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Moretti, Elena, Giulia Collodel, Giuseppe Belmonte, Daria Noto, and Emanuele Giurisato. "Defective spermatogenesis and testosterone levels in kinase suppressor of Ras1 (KSR1)-deficient mice." Reproduction, Fertility and Development 31, no. 8 (2019): 1369. http://dx.doi.org/10.1071/rd18386.

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The aim of this study was to clarify the role of the protein kinase suppressor of Ras1 (KSR1) in spermatogenesis. Spermatogenesis in ksr1−/− mice was studied in testicular tissue and epididymal spermatozoa by light and transmission electron microscopy and by immunofluorescence using antibodies to ghrelin and 3β-hydroxysteroid dehydrogenase (3β-HSD). Blood testosterone levels were also assessed. ksr1−/− mice showed reduced epididymal sperm concentration and motility as compared with wild-type (wt) mice. Testis tissue from ksr1−/− mice revealed a prevalent spermatogenetic arrest at the spermatocyte stage; the interstitial tissue was hypertrophic and the cytoplasm of the Leydig cells was full of lipid droplets. Ghrelin signal was present in the seminiferous tubules and, particularly, in the interstitial tissue of wt mice; however, in ksr1−/− mice ghrelin expression was very weak in both the interstitial tissue and tubules. On the contrary, the signal of 3β-HSD was weak in the interstitial tissue of wt and strong in ksr1−/− mice. Testosterone levels were significantly increased in the blood of ksr1−/− mice (P<0.05) as compared with wt. The results obtained reveal the importance of the KSR scaffold proteins in the spermatogenetic process. The study of the molecular mechanisms associated with spermatogenetic defects in a mouse model is essential to understand the factors involved in human spermatogenesis.
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de Kretser, D. M., K. L. Loveland, A. Meinhardt, D. Simorangkir, and N. Wreford. "Spermatogenesis." Human Reproduction 13, suppl 1 (April 1, 1998): 1–8. http://dx.doi.org/10.1093/humrep/13.suppl_1.1.

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Nishimura, Hitoshi, and Steven W. L’Hernault. "Spermatogenesis." Current Biology 27, no. 18 (September 2017): R988—R994. http://dx.doi.org/10.1016/j.cub.2017.07.067.

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Rodriguez-Sosa, Jose R., and Ina Dobrinski. "Recent developments in testis tissue xenografting." REPRODUCTION 138, no. 2 (August 2009): 187–94. http://dx.doi.org/10.1530/rep-09-0012.

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Development of the mammalian testis and spermatogenesis involve complex processes of cell migration, proliferation, differentiation, and cell–cell interactions. Although our knowledge of these processes has increased in the last few decades, many aspects still remain unclear. The lack of suitable systems that allow to recapitulate and manipulate both testis development and spermatogenesisex situhas limited our ability to study these processes. In the last few years, two observations suggested novel strategies that will improve our ability to study and manipulate mammalian spermatogenesis: i) testis tissue from immature animals transplanted ectopically into immunodeficient mice is able to respond to mouse gonadotropins and to initiate and complete differentiation to the level where fertilization-competent sperm are obtained, and ii) isolated testis cells are able to organize and rearrange into seminiferous cords that subsequently undergo complete development, including production of viable sperm. The current paper reviews recent advances that have been obtained with both techniques that represent novel opportunities to explore testis development and spermatogenesis in diverse mammalian species.
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Guha, T., A. Q. Siddiqui, and P. F. Prentis. "Ultrastructure of primary spermatocyte in fish (Tilapia: Oreochromis niloticus): The synaptonemal complex." Proceedings, annual meeting, Electron Microscopy Society of America 44 (August 1986): 288–89. http://dx.doi.org/10.1017/s0424820100143067.

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The Primary Spermatocytes represent a stage in spermatogenesis when the first meiotic cell division occurs. They are derived from Spermatogonium or Stem cell through mitotic division. At the zygotene phase of meiotic prophase the Synaptonemal complex appears in these cells in the space between the paired homologous chromosomes. Spermatogenesis and sperm structure in fish have been studied at the electron microscope level in a few species? However, no work has yet been reported on ultrastructure of tilapia, O. niloticus, spermatozoa and spermatogenetic process. In this short communication we are reporting the Ultrastructure of Primary Spermatocytes in tilapia, O. niloticus, and the fine structure of synaptonemal complexes seen in the spermatocyte nuclei.
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Rahadi, Yustisiane Ruth, Tri Wahyu Suprayogi, Rahmi Sugihartuti, Kadek Rachmawati, and Hani Plumeriastuti. "Effect of taurine on histopathological features of spermatogenesis in seminiferous tubules of mice (Mus musculus) induced by paraquat." Ovozoa : Journal of Animal Reproduction 11, no. 2 (August 17, 2022): 66–71. http://dx.doi.org/10.20473/ovz.v11i2.2022.66-71.

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This study aimed to determine the effect of taurine on the enhancement of the spermatogenetic process in male mice (Mus musculus) induced by paraquat (PQ). Twenty-five male mice (Mus musculus) aged 2-3 months with a bodyweight of around 35 grams were divided randomly into five groups. The K + and the treatment group (P1, P2, and P3) mice were induced using PQ. PQ was given intraperitoneally (IP) twice a week for 21 consecutive days at a dose of 30 mg/kg BW. Two hours after the administration of PQ, P1, P2, and P3 groups were given taurine at a dose of 250, 500, and 1000 mg/kg BW/day for three weeks (Heidari et al., 2019). K- group was given distilled water (IP) only. On day-29, mice were sacrificed for testicles histopathological preparations with hematoxylin-eosin staining. Results showed that the mice exposed to PQ only (the K+ group) had a reduced spermatogenesis score compared to those of the K- group (p <0.05). Taurine treatment on PQ-exposed mice was followed by an increase spermatogenesis score. The optimal curative dose of taurine was 500 mg/kg (P2 group). However, a higher dose (1000 mg/kg BW) of taurine resulted in a decline in the spermatogenesis score than those of at the 500 mg/kg. It could be concluded that treatment with taurine could enhance the spermatogenetic process of male mice (Mus musculus) induced by PQ.
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Meccariello, Rosaria, Rosanna Chianese, Vincenza Ciaramella, Silvia Fasano, and Riccardo Pierantoni. "Molecular Chaperones, Cochaperones, and Ubiquitination/Deubiquitination System: Involvement in the Production of High Quality Spermatozoa." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/561426.

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Spermatogenesis is a complex process in which mitosis, meiosis, and cell differentiation events coexist. The need to guarantee the production of qualitatively functional spermatozoa has evolved into several control systems that check spermatogenesis progression/sperm maturation and tag aberrant gametes for degradation. In this review, we will focus on the importance of the evolutionarily conserved molecular pathways involving molecular chaperones belonging to the superfamily of heat shock proteins (HSPs), their cochaperones, and ubiquitination/deubiquitination system all over the spermatogenetic process. In this respect, we will discuss the conserved role played by the DNAJ protein Msj-1 (mouse sperm cell-specific DNAJ first homologue) and the deubiquitinating enzyme Ubpy (ubiquitin-specific processing protease-y) during the spermiogenesis in both mammals and nonmammalian vertebrates.
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Rodrigues, Ramon T. G. A., José R. S. Santos, Lilianne M. S. Azerêdo, Ediane F. Rocha, Maria A. M. Carvalho, Maria J. I. D. Portal, Otávio B. Sousa, and Danilo J. A. Menezes. "Influence of scrotal bipartition on spermatogenesis yield and sertoli cell efficiency in sheep." Pesquisa Veterinária Brasileira 36, no. 4 (April 2016): 258–62. http://dx.doi.org/10.1590/s0100-736x2016000400002.

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Abstract With the objective to assess the effect of scrotal bipartition on spermatogenesis in sheep, the testes were used from 12 crossbred rams of sheep farms in the municipality of Patos, Paraíba, Brazil, distributed into two groups: GI with six rams with scrotal bipartition, and GII with six rams without scrotal bipartition. The testicular biometry was measured and the testes were collected, fixed in Bouin and fragments were processed to obtain histological slides. The spermatogenesis yield and the Sertoli cell efficiency was estimated by counting the cells of the spermatogenetic line at stage one of the seminiferous epithelium cycle and the Sertoli cells. The results were submitted to analysis of variance with the ASSISTAT v.7.6 program and the mean values were compared by the Student-Newman-Keuls test (SNK) at 5% significance. The testicular biometric parameters did not show statistical difference (p>0.05) between the groups. The meiotic, spermatogenetic and Sertoli cell efficiency were higher in bipartitioned rams (p<0.05), while the mitotic yield did not differ (p>0.05) between GI and GII. The results indicated that there is superiority in the spermatogenetic parameters of bi-partitioned rams, suggesting that these sheep present, as reported in goats, indication of better reproductive indices.
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Gribbins, Kevin. "Reptilian spermatogenesis." Spermatogenesis 1, no. 3 (July 2011): 250–69. http://dx.doi.org/10.4161/spmg.1.3.18092.

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Akdeniz, Ekrem, Mehmet Emin Onger, Mustafa Suat Bolat, Fatih Firat, Metin Gur, Onder Cinar, Mustafa Bakirtas, Abdullah Acıkgoz, and Fikret Erdemir. "Effect of atorvastatin on spermatogenesis in rats: A stereological study." Tropical Journal of Pharmaceutical Research 19, no. 12 (March 15, 2021): 2609–14. http://dx.doi.org/10.4314/tjpr.v19i12.19.

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Purpose: To investigate the effects of oral atorvastatin on spermatogenesis in a rat model.Methods: Rats were equally assigned into control and study groups, the latter receiving atorvastatin (20 mg/kg/day). At the end of 12 weeks, spermatogenetic activity was evaluated using stereological and optical fractionator methods. Serum follicle-stimulating hormone (FSH), total testosterone (TT), and luteinizing hormone (LH) levels were measured using micro–ELISA kits. Total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL - C), and high-density lipoprotein cholesterol levels were also measured by enzymatic colorimetric assays.Results: Testicular stereological analysis revealed that atorvastatin reduced Sertoli cell numbers (p < 0.001), spermatogonia (p < 0.001), spermatocytes (p < 0.001), and seminiferous tubule diameters (p < 0.001). LDL – C (p = 0.01) and TG (p = 0.01) values were significantly lower in the study group compared with the control group. There was no significant difference in FSH (p = 0.44), LH (p = 0.48),and TT (p = 0.06) levels between the groups.Conclusion: The findings show that atorvastatin causes deleterious effects on rat spermatogenesis. It should therefore be used with caution in clinical practice owing to its potential adverse effects, especially on male fertility. Keywords: Statin, Atorvastatin, Spermatogenesis, Stereology, Testis
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Dissertations / Theses on the topic "Spermatogenesis"

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Wahlgren, Aida. "Growth factors in spermatogenesis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-579-4/.

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Allenby, Gary. "Chemical disruption of spermatogenesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/18841.

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Over the past decade many publications attest to the substantial increase in public and scientific concern regarding the potential of industrial and environmental chemicals to interfere with male reproductive function. Spermatogenesis, (the process of sperm formation) depends on a series of complex biological interactions which can be interrupted at various stages by chemical insult. Recently a number of these chemicals have been used experimentally to directly disrupt testicular function to provide an insight into the processes involved in normal spermatogenesis. Based on these investigations the primary objective of the work in this thesis was to study the time course of development of testicular lesions, their stage specificity, and subsequent recovery of normal spermatogenesis using morphological and functional characteristics of function in vivo and in vitro. The chemicals used in these studies included meta dinitrobenzene (mDNB), nitrobenzene (NB), the isomers of mononitrotoluene (mNT) and 2-methoxyacetic acid (MAA). Within 24h of a single oral administration of mDNB or NB to rats there was a progressive decrease in testicular weight and increase in serum follicle stimulating hormone (FSH) levels coincident with widespread germ cell degeneration, as determined by histological examination of the testis. The degree of disruption induced by mDNB and its reversibility were time - but not stage - dependent with a decline in both sperm number and motility in parallel with germ cell degeneration. NB however had a more specific effect causing the initial degeneration of leptotene spermatocytes and subsequently more extensive germ cell loss involving round spermatids at a number of stages. During the recovery of spermatogenesis a considerable change was observed in the frequency of occurrence of spermatogenic stages in comparison to controls. These changes remained significantly different up to at least 70 days post-treatment. The isomers of mNT induced small but statistically significant dose-dependent decreases in testicular weight. Spermatogenesis in these animals remained qualitatively normal, so detailed histological studies were not undertaken. Further investigation into the effects of the testicular toxicants listed above was performed in vitro using Sertoli cell monocultures and Sertoli cell-germ cell co-cultures. mDNB, NB and the isomers of mNT produced dose-dependent increases in germ cell exfoliation (from co-cultures). mDNB and NB also produced histological changes in culture including Sertoli cell vacuolation and phagocytosis of germ cells, and induced dose-dependent increases in the secretion of lactate and pyruvate, two established indices of Sertoli cell function in vitro. Sertoli cells secrete over 100 different proteins, only a handful of which have been characterised and a role in spermatogeneis proposed. One of these proteins is inhibin. The potenial of inhibin secretion as a further index of Sertoli cell function (or dysfunction) in monocultures and co-cultures has been investigated. mDNB, NB, 2-mNT and 3-mNT all induced dose-dependent alterations in the secretion of inhibin in vitro. Historically, FSH has been postulated to control inhibin secretion in a classical negative feedback manner. Recent evidence obtained in vivo and in co-culture suggests that its secretion may be controlled by specific type(s) of germ cells. Seminiferous tubule cultures represent a potentially more useful culture system to investigate this further. They present a unique opportunity to study Sertoli cell-germ cell interactions under more physiological conditions since the integrity of the seminiferous epithelium is maintained in vitro. Previous investigators have demonstrated that MAA specifically destroys pachytene spematocytes in vivoand this specificity of action was utilised to study which germ cel-Sertoli cell interactions control the secretion of inhibin. At selected times after MAA treatment when specific complements of germ cells were absent or grossly depleted, seminiferous tubules were isolated and cultured to measure inhibin secretion under basal or stimulated conditions. The results demonstrate that elongate spematids are the primary germ cell type which exerts major control over inhibin secretion under both basal and FSH-stimulated conditions. In conclusion, these studies demonstrate: Firstly that these compounds can be used as a means to investigate normal spermatogenesis. Secondly, effects of these compounds on spermatogenesis can be demonstrated both in vivo and in vitro. Finally, that the seminiferous tubule culture technique represents a more physiological approach with which to investigate in vivo - in vitro comparative toxicity with respect to chemically induced disruption of spermatogenesis.
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Turner, Katie Jane. "Prospects for monitoring spermatogenesis." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/21577.

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The aims of the studies in this thesis were, firstly, to investigate the feasibility of detecting proteins derived from the seminiferous epithelium in testicular interstitial fluid, spermatic vein blood, testicular vein blood and also in peripheral blood. Secondly, to identify proteins might be potential markers of adverse effects on spermatogenesis. An antiserum was raised against seminiferous tubule secreted proteins and was used in conjunction with Western blot analysis to detect testicular proteins in biological fluids and also to screen a testis cDNA library to identify novel secretory products. Western blot analysis was only able to detect proteins secreted by seminiferous tubules in testicular interstitial fluid, but not in spermatic, testicular or peripheral venous plasma from adult rats. The antiserum specifically detected three proteins in testicular IF from control animals. The disruption of spermatogenesis by short-term testicular heat treatment 24 hours earlier (43°C for 30min) increased the abundance of these proteins and induced the appearance of several other less abundant proteins, all with molecular masses below 25 kDa. Two of the proteins present in IF were identified as germ cell secretory products, phosphatidylethanolamine binding protein and an androgen regulated protein (ARP-2). These results suggest that germ cell, as well as Sertoli cell, secretory products can gain access to the interstitium under both normal physiological conditions and more easily after testicular damage. The antiserum was unable to detect these proteins in peripheral blood even after heat treatment; this may be due to the insensitivity of the techniques used. However, this approach has identified two candidate proteins for the development of specific immunoassays, which will then enable more definitive assessment of whether proteins secreted by the seminiferous epithelium can be measured in blood.
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Vries, Johannes Wilhelmus Albertus de. "The DAZ genes and impaired spermatogenesis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/86215.

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Shoji, Masanobu. "RNA interference during spermatogenesis in mice." Kyoto University, 2006. http://hdl.handle.net/2433/143821.

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Tam, Yuen-tsung. "Spatiotemporal expression of VAD1.2/AEP2 in spermatogenesis." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558071.

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Jue, Kathleen. "Regulation of DNA methyltransferase expression during spermatogenesis." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22746.

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Patterns of methylation at the 5-position of cytosine are postulated to be involved in several mammalian processes such as the regulation of gene expression, genomic imprinting and X chromosome inactivation. Disruptions in methylation patterns affect embryonic development and are involved in carcinogenesis, indicating the importance of regulating these patterns. The establishment of methylation patterns is believed to be initiated during gametogenesis and continue during early embryonic development. DNA (cytosine-5)-methyltransferase (EC2.1.1.37) (DNA methyltransferase) is the only known mammalian enzyme that catalyzes the formation of 5-methyl cytosine. Here, DNA methyltransferase is proposed to play a key role in establishing and maintaining methylation patterns during male gametogenesis and is predicted to be regulated during spermatogenesis. The regulation of DNA methyltransferase mRNA during testicular development in mouse and rat was first established as preliminary evidence for the regulation of DNA methyltransferase during spermatogenesis. Highly enriched populations of spermatogenic cell types were then isolated from mouse testes and examined for DNA methyltransferase mRNA and protein expression. Expression of DNA methyltransferase protein was proportional to the levels of a 5.2 kb mRNA. Substantial levels of protein and 5.2 kb mRNA were observed in mitotic types A and B spermatogonia, preleptotene spermatocytes, meiotic leptotene/zygotene spermatocytes and postmeiotic round spermatids but barely detectable in pachytene spermatocytes in which a large decrease in 5.2 kb mRNA levels and the appearance of a 6.2 kb transcript was observed. The subcellular localization of DNA methyltransferase in germ cells was also regulated. These findings reveal DNA methyltransferase to be highly regulated during spermatogenesis and support a role for the enzyme in events associated with germ line methylation changes such as developmental gene regulation, genomic imprintin
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Tam, Yuen-tsung, and 譚婉頌. "Spatiotemporal expression of VAD1.2/AEP2 in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558071.

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Gao, Jing, and 高晶. "Roles of VAD1.3 in spermatogenesis and fertilization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B4852170X.

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　　Vad1.3 is an evolutionarily-conserved, testis-specific gene identified from a retinol-treated Vitamin A-deficiency (VAD) rat model. VAD1.3 is expressed throughout spermiogenesis at the acrosome of spermatids and epididymal spermatozoa, suggesting a role in acrosome biogenesis or acrosome reaction. The present study aimed to explore the functional role of VAD1.3 in spermatogenesis and sperm functions by the cellular and gene-knockout approaches. 　　Double immunofluorescent microscopy confirmed the co-localization of VAD1.3 and syntaxin 1 in mouse spermatids and spermatozoa. Deletion analysis of the Vad1.3 gene in transfected mouse spermatocyte GC2-spd and human cervical cancer HeLa cells revealed a polarized peri-nuclear/Golgi expression pattern for the N-terminal GFP-VAD fusion proteins which contain a bipartite nucleus localization (BNL) motif, but a nuclear expression pattern for the C-terminal GFP-VAD. The N-terminal sequences of VAD1.3 mediated its interaction with syntaxin 1, as demonstrated by both co-localization and co-immunoprecipitation studies. The full-length GFP-VAD co-localized with the Golgi markers and was redistributed into the endoplasmic reticulum after brefeldin A treatment, suggesting that VAD1.3 was recruited through the ER-Golgi-acrosome pathway. 　　Vad1.3+/- mice was previously generated by the conventional knockout approach. The heterozygous mice had normal spermatogenesis during postnatal days and adulthood (6-8 weeks). At the age of 8-19 months, 6 out of 17 heterozygous mice but no wild-type exhibited a decrease in the epididymal sperm count and testicular weight (p < 0.05). Histological analyses unveiled disarrangement of the seminiferous epithelium and sloughing of germ cells, predominantly spermatids, which was mediated partially by apoptosis as a higher percentage of TUNEL-positive cells were detected in these heterozygous mice (p < 0.05). This phenotype was associated with a decrease in the mRNA (p < 0.05) and protein levels of VAD1.3 in the testis. 　　Crossing of the Vad1.3+/- mice produced wild-type and heterozygous offspring in a ratio of 1:3, but no Vad1.3-/- mice were found. There was no significant difference between the heterozygous intercrosses and the wild-type intercrosses in the number of oocytes ovulated, the developmental rate of embryos from zygotes to blastocysts, the number of implantation site, resorption site or the offspring could result from defective fertilization between Vad1.3 null gametes rather than developmental lethality. The role of VAD1.3 in fertilization was supported by the inhibitory effects of the anti-VAD1.3 antibody on in vitro fertilization and progesterone-induced acrosome reaction. Immuno-staining revealed that VAD1.3 was present in the acrosome-intact spermatozoa but not in acrosome-reacted spermatozoa, indicating a role of VAD1.3 in ZP-binding or acrosome reaction rather than sperm-egg fusion. In oocytes VAD1.3 was distributed in the cytoplasm near the cortex. litter size. Only a few Vad1.3-/- embryos were found at the zygotic (3.7%) and 2-cell (3%) stages in the heterozygous intercrosses. These findings suggested that the absence of the Vad1.3-/- 　　In sum, VAD1.3 may play important roles in fertilization and spermatogenesis in mice. The BNL motif of VAD1.3 directs its Golgi expression and the N-terminal sequence of the protein mediates its interaction with syntaxin 1. The use of tissue-specific knockout approach may help to answer the functional role of VAD1.3 in future.
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Al-Jaru, Ayman I. "Equine spermatogenesis : meiotic chromosome behavior and recombination." Thesis, University of Central Lancashire, 2010. http://clok.uclan.ac.uk/1762/.

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Studying the spermatogenesis of horse is beneficial for the horse industry by identifying the causes of chromosomal abnormalities, which cause embryonic loss, congenital abnormalities and infertility. Little is known about the spermatogenesis in horse. This is the first report that investigates the horse spermatogenesis in detail, particularly metaphase I (MI) and prophase I (PI) stages of the first meiotic division. Meiotic recombination is considered to be the major outcome of meiosis. It is essential for proper chromosome segregation and formation of normal haploid gametes. Analysis of recombination frequency and distribution are crucial for genomic and association studies. Any alteration of the recombination frequency and positioning can cause non-disjunction and generation of aneuploidy. The frequency and distribution of chiasmata were estimated at MI chromosomes from fourteen fertile stallions. The average frequency of autosomal chiasmata was 49.45 ± 2.07, corresponding to a genetic length of 2,472.5 cM. All autosomal bivalents had at least one chiasma. The majority of chromosomes have one or two chiasmata, which are mostly distally localized. The frequency and the distribution as well as the genetic length of chiasmata were also estimated for the first time in eight different individual autosomes. Immunofluorescent localization was used to characterize the early stages of the first meiotic division as well as to examine the frequency and the distribution of DNA mismatch repair protein MutL Homologous Protein 1 (MLH1) foci on synaptonemal complexes (SCs) from sex fertile stallions. The mean frequency of autosomal recombination foci was 50.11±2.35. All autosomal bivalents had at least one recombination focus. In general, foci were located near the distal ends with some foci interstitially distributed. The distribution of MLH1 foci indicated positive interference; however, foci were very close to one another in rare instances. The average SCs relative length was highly correlated with the average number of MLH1 foci. MLH1 have been proposed to mark crossover sites at PI since the frequency and distribuation of MLH1 foci closely correspond to the frequency and distribution of chiasmata on MI chromosomes. iii | P a g e Spermatozoa viability, which include spermatozoa head and tail membrane integrity, acrosomal integrity and mitochondrial function assessment are the main sperm analysis parameters considered in this thesis to evaluate the stallion fertility using epididymal collected semen samples. The mean percentage of spermatozoa with viable heads and tails, using Chicago sky blue stain, was 81.26 ± 5.06. FITC-Pisum sativum agglutinin (FITC-PSA) and MitoTracer green were used successfully to assess the spermatozoal acrosomal status as well as the mitochondrial function, respectively. The mean percentage of spermatozoa with integrated acrosome was 93.85 ± 1.9, while for functional mitochondria was 95.63 ± 1.63. In conclusion, this finding is the cornerstone to understanding the genetic basis of normal horse spermatogenesis. Simultaneous assessment of different functional sperm parameters as well as investigating the synapsis and recombination frequency and distribution, at PI or MI, would assist with predictions of stallion fertility prior to breeding. In addition, this study will enable investigators to use linkage analysis in identifying and localising different genetic loci associated with specific traits.
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Books on the topic "Spermatogenesis"

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Cheng, C. Yan. Spermatogenesis. Edited by C. Yan Cheng. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634.

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Carrell, Douglas T., and Kenneth I. Aston, eds. Spermatogenesis. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-038-0.

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Nieschlag, Eberhard, and Ursula-F. Habenicht, eds. Spermatogenesis — Fertilization — Contraception. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-662-02815-5.

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Gupta, G. S. Proteomics of Spermatogenesis. Boston, MA: Springer US, 2005. http://dx.doi.org/10.1007/0-387-27655-6.

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Hennig, Wolfgang, ed. Spermatogenesis Genetic Aspects. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-540-47184-4.

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1941-, Hennig Wolfgang, ed. Spermatogenesis: Genetic aspects. Berlin: Springer-Verlag, 1987.

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1941-, Hennig Wolfgang, ed. Spermatogenesis: Genetic aspects. Berlin: Springer-Verlag, 1987.

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Cheng, C. Yan, and Fei Sun, eds. Molecular Mechanisms in Spermatogenesis. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-77779-1.

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Cheng, C. Yan, ed. Molecular Mechanisms in Spermatogenesis. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-09597-4.

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Yan, Cheng C., ed. Molecular mechanisms in spermatogenesis. New York: Springer Science+Business Media, 2008.

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Book chapters on the topic "Spermatogenesis"

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Hermo, Louis, Regiana L. Oliveira, Charles E. Smith, Catherine E. Au, and John J. M. Bergeron. "Golgi apparatus regulation of differentiation." In Spermatogenesis, 1–40. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-1.

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Punjani, Nahid, Ryan Flannigan, and Peter N. Schlegel. "Regulation of fertility and infertility in humans." In Spermatogenesis, 123–38. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-10.

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Flannigan, Ryan, and Marc Goldstein. "Male infertility." In Spermatogenesis, 139–54. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-11.

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Wong, Chris KC. "Effects of chemical pollutants on spermatogenesis and implications in male infertility." In Spermatogenesis, 155–67. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-12.

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Wen, Qing, Elizabeth I. Tang, Tito Jesus, Bruno Silvestrini, and C. Yan Cheng. "Advances in our understanding of human spermatogenesis." In Spermatogenesis, 168–82. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-13.

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Tang, Elizabeth I., Christopher L. Robinson, Chi Nok Chong, Shuibing Chen, and C. Yan Cheng. "A look into the testis as a reservoir for HIV and ZIKV—A reproductive biologist’s perspective." In Spermatogenesis, 183–90. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-14.

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O’Donnell, Liza, and Peter G. Stanton. "Cytoskeletons (F-actin) and spermatogenesis." In Spermatogenesis, 191–200. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-15.

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Ye, Lan, and Ke Zheng. "Roles of mTOR signaling in spermatogenesis." In Spermatogenesis, 201–10. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-16.

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Li, Linxi, Haiqi Chen, Qingquan Lian, Ren-Shan Ge, and C. Yan Cheng. "Does planar cell polarity matter during spermatogenesis?" In Spermatogenesis, 211–19. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-17.

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Jenardhanan, Pranitha, Manivel Panneerselvam, and Premendu P. Mathur. "Computational characterization and integrative analysis of proteins involved in spermatogenesis." In Spermatogenesis, 220–33. Boca Raton, FL : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/9780429488634-18.

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Conference papers on the topic "Spermatogenesis"

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Weixiang Liu, Aifa Tang, Datian Ye, and Zhen Ji. "Nonnegative singular value decomposition for microarray data analysis of spermatogenesis." In 2008 International Conference on Technology and Applications in Biomedicine (ITAB). IEEE, 2008. http://dx.doi.org/10.1109/itab.2008.4570528.

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Liu, Weixiang, Aifa Tang, Kehong Yuan, and Datian Ye. "Novel and Significant Spermatogenesis-related Gene Selection and Confirmation with Microarrays." In 11th Joint Conference on Information Sciences. Paris, France: Atlantis Press, 2008. http://dx.doi.org/10.2991/jcis.2008.89.

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Gong, Tianxue, Weixiang Liu, Lan Tao, Liandong Liu, and Aifa Tang. "Notice of Retraction: Spermatogenesis-Related Gene Selection by Singular Value Decomposition and Correlation Analysis." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780088.

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Bakhtyukov, Andrej, Kira Derkach, Lyubov' Bayunova, Inna Zorina, Vikas Roy, Alexej Gryaznov, and Alexander Shpakov. "THE PROCESSES OF STEROIDOGENESIS AND SPERMATOGENESIS IN MALE MICE WITH TYPE 1 DIABETES MELLITUS." In XVI International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m939.sudak.ns2020-16/88.

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"Whole-exome sequencing association studies on impaired spermatogenesis in different ethnic groups in Russia." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-286.

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Andreeva, E. S., V. A. Vokina, and L. M. Sosedova. "REPROTOXIC PROPERTIES OF WILDFIRE SMOKE OF VARIOUS DURATIONS IN THE EXPERIMENT." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-18-22.

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Climate change is intensifying the global activity of wildfires, in connection with which the liquidators of the Ministry of Emergency Situations are increasingly exposed to dangerous air pollution during large-scale smoke. Objective: to conduct a comparative characterization of the burning products effect released during wildfires of different duration on the functional state of the reproductive system of white rats. Materials and methods. Experimental studies were carried out on 230 mongrel white sexually mature rats. The duration of exposure was carried out in 3 different exposure modes, for 1 day, 7 days for 4 hours a day and 4 weeks for 5 days a week for 4 hours a day. After the end of exposure, the functional activity of the sexual gonads of animals, mating for offspring and evaluation of their postnatal development were evaluated. 19 Results. It was found that prolonged exposure to smoke for 4 weeks, 5 days a week, has the most pronounced effect on the spermatogenesis indicators of mature male rats. Exposure to smoke for 1 day and 7 days did not have a significant effect on the spermatogenesis of white rats, however, an increase in postnatal mortality was found in the offspring of the first generation, which was observed in all exposure modes. Conclusions. Exposure to the smoke of a natural fire affects the male reproductive potential of animals, resulting in a decrease in the survival rate of their newborn offspring.
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Hatakeyama, Masatsugu. "Function of theDeleted Azoospermia(DAZ) family gene in spermatogenesis in haploid male of the sawfly." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94413.

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Mohammad Hasan AL-MURSHIDI, Manar, Walaa Salih HASSAN, and Hala M.N. AL-SAILY. "AMELIORATIVE EFFECT OF BETA CAROTENE AGAINST TITANIUM DIOXIDE NANOPARTICLES REPRODUCTIVE TOXICITY ON TESTIS AND EPIDIDYMIS OF MALE ALBINO MICE MUS MUSCULUS." In IV.International Scientific Congress of Pure,Appliedand Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress4-20.

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The present study aimed to evaluate the improving or ameliorative effect of beta carotene on titanium dioxide nanoparticles induced testicular toxicity at the histological level. Forty adult healthy male albino mice weighting between 30-37gm and aged 12 to 15. Animals were randomly grouped in to four groups with ten mice in each: the first one was administered normal saline, whereas second group mice were administered 10 mg\kg body weight of beta carotene, third group were given 300 mg\kg body weight of titanium dioxide solution, last fourth group were administered 300 mg\kg body weight of titanium dioxide solution and 10 mg\kg body weight of beta carotene after two hours of every titanium uptake after ten days of pre protective administration of10 mg\kg body weight beta carotene ; all for thirty five days. Results exhibited that the histological toxic effects induced by A 300 mg\kg titanium dioxide nanoparticles administered mice testis showing germinal epithelium sloughing and odema with irregular spermatogenesis .and showing That epididymal epithelium exhibiting lipid vacuoles in the supranuclear region of the principal cells, with papillary infoldings lined by columnar cells and occur hyperplasia of clear cells, Some lumens were devoid of sperm with few cellular debris, also showed atrophy in the smooth muscle between ducts with Inflammatory infiltrate in connective tissue. A group treated with 300 mg\kg titanium dioxide NPs plus 10 mg\kg body weight administered mice that testis and epididymis showing an intact of histologic architecture. And the above effects were ameliorated by the administration of beta carotene, and the pre protective effect of beta carotene increased that effect. In conclusion Beta carotene has improving effects against the histological damage in testis and epididymis and the arrest in spermatogenesis that resulted from the toxicity of titanium dioxide nanoparticles as it repair the damaged parameters and obtaining control like features
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Osypchuk, G., Nina Bradu, Irina Gengera, Ion Balan, and S. Povetkin. "К вопросу влияния биологически активных веществ (БАВ) на сперматогенез и некоторые биохимические показатели крови." In Scientific and practical conference with international participation: "Management of the genetic fund of animals – problems, solutions, outlooks". Scientific Practical Institute of Biotechnologies in Animal Husbandry and Veterinary Medicine, 2023. http://dx.doi.org/10.61562/mgfa2023.40.

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The use of biologically active substances allows you to activate the functions of all organs and systems of the body. The aim of the research was to study the effect of BAS agents on the qualitative and quantitative parameters of sperm and some biochemical parameters of the blood of boars and rams. During the research, it was found out that the non-hormonal BAS agents used by us can improve spermatogenesis, do not have a negative effect on the body, stimulate metabolic processes. It was found that the qualitative and quantitative parameters of the seed (the number of live sperms and the number of rectilinearly translational sperms) increase more intensively in animals of the experimental groups.
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Arabacı Tamer, Sevil. "Testicular torsion-induced tubular injury and disturbed spermatogenesis in rats were improved with an estrogen receptor-beta agonist." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-185.

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Reports on the topic "Spermatogenesis"

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Physiology of spermatogenesis. BJUI Knowledge, December 2017. http://dx.doi.org/10.18591/bjuik.0508.

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