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1

Grimm, Johannes, Juliane Nell, Andreas Hillenbrand, et al. "Immunohistological detection of small particles of Echinococcus multilocularis and Echinococcus granulosus in lymph nodes is associated with enlarged lymph nodes in alveolar and cystic echinococcosis." PLOS Neglected Tropical Diseases 14, no. 12 (2020): e0008921. http://dx.doi.org/10.1371/journal.pntd.0008921.

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Background Alveolar (AE) and cystic echinococcosis (CE) in humans are caused by the metacestode of the tapeworms Echinococcus multilocularis and Echinococcus granulosus sensu lato (s.l.). Immunohistochemistry with the monoclonal antibodies (mAb) Em2G11, specific for AE, and the mAb EmG3, specific for AE and CE, is an important pillar of the histological diagnosis of these two infections. Our aim was to further evaluate mAb EmG3 in a diagnostic setting and to analyze in detail the localization, distribution, and impact of small particles of Echinococcus multilocularis (spems) and small particle
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2

Grimm, Johannes, Julian Krickl, Annika Beck, et al. "Establishing and evaluation of a polymerase chain reaction for the detection of Echinococcus multilocularis in human tissue." PLOS Neglected Tropical Diseases 15, no. 2 (2021): e0009155. http://dx.doi.org/10.1371/journal.pntd.0009155.

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Background Alveolar echinococcosis (AE) is caused by metacestode larva of the tapeworm Echinococcus multilocularis. AE diagnostics currently rely on imaging techniques supported by serology, but unequivocal detection of AE is difficult. Although polymerase chain reaction (PCR)-based methods to detect tapeworm DNA in biopsies have been suggested for several species, no validated protocol adhering to accepted guidelines has so far been presented for AE diagnostics. We herein established a PCR protocol for metacestode biopsies and technically evaluated the method using isolated parasite DNA and c
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3

Schütz, Alexander C., Doris I. Braun, and Karl R. Gegenfurtner. "Chromatic Contrast Sensitivity During Optokinetic Nystagmus, Visually Enhanced Vestibulo-ocular Reflex, and Smooth Pursuit Eye Movements." Journal of Neurophysiology 101, no. 5 (2009): 2317–27. http://dx.doi.org/10.1152/jn.91248.2008.

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Recently we showed that sensitivity for chromatic- and high-spatial frequency luminance stimuli is enhanced during smooth-pursuit eye movements (SPEMs). Here we investigated whether this enhancement is a general property of slow eye movements. Besides SPEM there are two other classes of eye movements that operate in a similar range of eye velocities: the optokinetic nystagmus (OKN) is a reflexive pattern of alternating fast and slow eye movements elicited by wide-field visual motion and the vestibulo-ocular reflex (VOR) stabilizes the gaze during head movements. In a natural environment all th
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4

Berryhill, Marian E., Tanya Chiu, and Howard C. Hughes. "Smooth Pursuit of Nonvisual Motion." Journal of Neurophysiology 96, no. 1 (2006): 461–65. http://dx.doi.org/10.1152/jn.00152.2006.

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Unlike saccades, smooth pursuit eye movements (SPEMs) are not under voluntary control and their initiation generally requires a moving visual target. However, there are various reports of limited smooth pursuit of the motion of a subject’s own finger in total darkness (pursuit based on proprioceptive feedback) and to the combination of proprioception and tactile motion as an unseen finger was moved voluntarily over a smooth surface. In contrast, SPEMs to auditory motion are not distinguishable from pursuit of imagined motion. These reports of smooth pursuit of nonvisual motion cues used a vari
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5

Grimm, Johannes, Annika Beck, Juliane Nell, et al. "Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis." Pathogens 9, no. 8 (2020): 634. http://dx.doi.org/10.3390/pathogens9080634.

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Alveolar echinococcosis (AE) is caused by the intermediate stage of Echinococcus multilocularis. We aimed to correlate computed tomography (CT) data with histology to identify distinct characteristics for different lesion types. We classified 45 samples into five types with the Echinococcus multilocularis Ulm Classification for Computed Tomography (EMUC-CT). The various CT lesions exhibited significantly different histological parameters, which led us to propose a progression model. The initial lesion fit the CT type IV classification, which comprises a single necrotic area with the central lo
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6

Scarone, Silvio, Orsola Gambini, Elena Häfele, Laura Bellodi, and Enrico Smeraldi. "Neurofunctional assessment of schizophrenia: A preliminary investigation of the presence of eye-tracking (SPEMS) and quality extinction test (QET) abno." Biological Psychology 24, no. 3 (1987): 253–59. http://dx.doi.org/10.1016/0301-0511(87)90006-8.

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7

Ricken, Franz J., Juliane Nell, Beate Grüner, et al. "Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions." PLOS Neglected Tropical Diseases 11, no. 5 (2017): e0005636. http://dx.doi.org/10.1371/journal.pntd.0005636.

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8

Zhou, Linglin, Di Liu, Li Liu, et al. "Recent Advances in Self-Powered Electrochemical Systems." Research 2021 (March 12, 2021): 1–15. http://dx.doi.org/10.34133/2021/4673028.

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Electrochemistry, one of the most important research and production technology, has been widely applicated in various fields. However, the requirement of external power source is a major challenge to its development. To solve this issue, developing self-powered electrochemical system (SPES) that can work by collecting energy from the environment is highly desired. The invention of triboelectric nanogenerator (TENG), which can transform mechanical energy into electricity, is a promising approach to build SPES by integrating with electrochemistry. In this view, the latest representative achievem
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9

Pack, Christopher, Stephen Grossberg, and Ennio Mingolla. "A Neural Model of Smooth Pursuit Control and Motion Perception by Cortical Area MST." Journal of Cognitive Neuroscience 13, no. 1 (2001): 102–20. http://dx.doi.org/10.1162/089892901564207.

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Smooth pursuit eye movements (SPEMs) are eye rotations that are used to maintain fixation on a moving target. Such rotations complicate the interpretation of the retinal image, because they nullify the retinal motion of the target, while generating retinal motion of stationary objects in the background. This poses a problem for the oculomotor system, which must track the stabilized target image while suppressing the optokinetic reflex, which would move the eye in the direction of the retinal background motion (opposite to the direction in which the target is moving). Similarly, the perceptual
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10

Hollis, A. S. "Rights of Way in Ovid (Heroides 20.146) and Plautus (Curculio 36)." Classical Quarterly 44, no. 2 (1994): 545–49. http://dx.doi.org/10.1017/s0009838800044049.

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Acontius rhetorically addresses the young man to whom Cydippe's parents have betrothed her, whom he imagines as showing excessive familiarity while visiting the girl's sickbed. In line 146, ‘spes’ may be considered the vulgate reading; the noun can be used concretely, of the object of one's hopes (OLD 4), a person in whom hopes are centred (OLD 5), or sometimes as an endearment (OLD 5c). For application to a girl with suitors, cf. Ovid, Met. 4.795 ‘multorumque fuit spes invidiosa procorum’. Or one could take ‘spes’ in Her. 20.146 generally, = id quod spero. But, in any case, ‘spes’ is somewhat
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11

Hicks, Matthew, Cynthia Sturton, Samuel T. King, and Jonathan M. Smith. "SPECS." ACM SIGPLAN Notices 50, no. 4 (2015): 517–29. http://dx.doi.org/10.1145/2775054.2694366.

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12

Hicks, Matthew, Cynthia Sturton, Samuel T. King, and Jonathan M. Smith. "SPECS." ACM SIGARCH Computer Architecture News 43, no. 1 (2015): 517–29. http://dx.doi.org/10.1145/2786763.2694366.

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13

Burns-Cox, Christopher. "Sluggish sperms." Lancet 369, no. 9570 (2007): 1346. http://dx.doi.org/10.1016/s0140-6736(07)60632-1.

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14

Woods, Paul. "DESIgner specs." Nature Astronomy 3, no. 5 (2019): 386. http://dx.doi.org/10.1038/s41550-019-0775-2.

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15

Reinecke, A. J. "Sperms verklap omgewingsbesoedeling." Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie 14, no. 4 (1995): 132. http://dx.doi.org/10.4102/satnt.v14i4.623.

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16

Ajayi, Abayomi B., Bamgboye M. Afolabi, Victor D. Ajayi, Ifeoluwa Oyetunji, Oluwafunmilola Biobaku, and Adedamilola Atiba. "Men without Sperms." Open Journal of Urology 08, no. 01 (2018): 25–42. http://dx.doi.org/10.4236/oju.2018.81004.

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17

Spence, Des. "X ray specs." BMJ 336, no. 7650 (2008): 962.1–962. http://dx.doi.org/10.1136/bmj.39559.547118.94.

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18

Summerton, Os. "The Rainbow Specs." Transactional Analysis Journal 22, no. 3 (1992): 182–88. http://dx.doi.org/10.1177/036215379202200309.

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19

Grady, Brian. "MEET SPE'S PRESIDENT." Plastics Engineering 74, no. 6 (2018): 4–5. http://dx.doi.org/10.1002/j.1941-9635.2018.tb01895.x.

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20

Zandonella, Catherine. "T-ray specs." Nature 424, no. 6950 (2003): 721–22. http://dx.doi.org/10.1038/424721a.

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21

&NA;. "PC-SPES." Reactions Weekly &NA;, no. 956 (2003): 12–13. http://dx.doi.org/10.2165/00128415-200309560-00042.

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22

&NA;. "PC-SPES." Reactions Weekly &NA;, no. 899 (2002): 14. http://dx.doi.org/10.2165/00128415-200208990-00050.

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23

Ko, Richard, Raymond D. Wilson, and Susan Loscutoff. "PC-SPES." Urology 61, no. 6 (2003): 1292. http://dx.doi.org/10.1016/s0090-4295(02)02508-6.

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24

Nagourney, Robert A. "PC-SPES." Journal of Medicinal Food 5, no. 3 (2002): 107–8. http://dx.doi.org/10.1089/10966200260398134.

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25

Naoman, U. D. "Sperms biometry of local Iraqi Awassi Rams." Al-Qadisiyah Journal of Veterinary Medicine Sciences 12, no. 2 (2013): 19. http://dx.doi.org/10.29079/vol12iss2art252.

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This study was designed to estimate of sperms biometry in local Iraqi Awassi rams. Five mature rams of 2.5-4 years old and 37-44 Kg live body weight were used in this study. Semen collection was performed by using an artificial vagina. Semen samples were evaluated immediately after collection of total 30 ejaculates. Semen volume and color, mass and individual sperms motility, live and abnormal sperms, as well as sperms concentration, were estimated. sperms biometry calculated by using phase contrast microscope and occulo-micrometer lens. Semen biometry means which estimated in this study were;
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26

Radzievskii, Vitalii Aleksandrovich. "Contemporary culture of Ukraine: contra spem spero." Vestnik of Saint Petersburg State University of Culture 2 (June 2018): 53–58. http://dx.doi.org/10.30725/2619-0303-2018-2-53-58.

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27

Thompson, William M. "Gaudium et Spes: We are in the “Spes” Part." Horizons 26, no. 2 (1999): 322–25. http://dx.doi.org/10.1017/s0360966900032114.

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28

Noda, Yoshihiro, Mera S. Barr, Reza Zomorrodi, et al. "Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients." Journal of Personalized Medicine 11, no. 1 (2021): 54. http://dx.doi.org/10.3390/jpm11010054.

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Background: The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ). Methods: We compared the spatiotemporal characteristics of TEPs induced by spTMS among the gr
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29

Chen, Chung-Hwan, Yi-Shan Lin, Yin-Chih Fu, et al. "Electromagnetic fields enhance chondrogenesis of human adipose-derived stem cells in a chondrogenic microenvironment in vitro." Journal of Applied Physiology 114, no. 5 (2013): 647–55. http://dx.doi.org/10.1152/japplphysiol.01216.2012.

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We tested the hypothesis that electromagnetic field (EMF) stimulation enhances chondrogenesis in human adipose-derived stem cells (ADSCs) in a chondrogenic microenvironment. A two-dimensional hyaluronan (HA)-coated well (2D-HA) and a three-dimensional pellet culture system (3D-pellet) were used as chondrogenic microenvironments. The ADSCs were cultured in 2D-HA or 3D-pellet, and then treated with clinical-use pulse electromagnetic field (PEMF) or the innovative single-pulse electromagnetic field (SPEMF) stimulation. The cytotoxicity, cell viability, and chondrogenic and osteogenic differentiat
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30

Mesquita, Pedro. "SPEMD – Biénio 2014‐2015." Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial 55, no. 1 (2014): 1–2. http://dx.doi.org/10.1016/j.rpemd.2014.02.001.

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31

Mesquita, Pedro. "SPEMD – Biénio 2016‐2017." Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial 56, no. 4 (2015): 205–6. http://dx.doi.org/10.1016/j.rpemd.2015.12.001.

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32

Harker, Maurice. "New specs for 2000." Housing, Care and Support 3, no. 1 (2000): 2–3. http://dx.doi.org/10.1108/14608790200000001.

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33

Hecht, Jeff, and Vijaysree Venkatraman. "Scrap those 3D specs." New Scientist 215, no. 2874 (2012): 20. http://dx.doi.org/10.1016/s0262-4079(12)61862-4.

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34

Lamming, M., and D. Bohm. "SPECs: personal pervasive systems." Computer 36, no. 6 (2003): 109–11. http://dx.doi.org/10.1109/mc.2003.1204383.

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35

AUSTIN, C. R. "Are Sperms Really Necessary?" Development, Growth and Differentiation 28, s1 (1986): 1–2. http://dx.doi.org/10.1111/j.1440-169x.1986.28s1_1.x.

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36

Araki, Yasuyuki, Midori Yoshizawa, Hiroyuki Abe, Yoshihiko Murase, and Yasuhisa Araki. "Use of mouse oocytes to evaluate the ability of human sperm to activate oocytes after failure of activation by intracytoplasmic sperm injection." Zygote 12, no. 2 (2004): 111–16. http://dx.doi.org/10.1017/s0967199404002606.

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The objective of the present study was to investigate the nuclei of human sperms that failed to fertilize human oocytes after intracytoplasmic sperm injection (ICSI). The sperms were injected into mouse oocytes by a piezo-micromanipulator, and some of these oocytes were artificially activated with strontium chloride (SrCl2) after ICSI. The oocytes were fixed, stained, and subjected to chromosomal analysis. The survival rate of mouse oocytes injected with infertile human sperms was 92.0% (46/50), while that of the control mouse oocytes injected with fertile human sperms was 73.6% (81/110). The
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37

Zaporozhets, O. M., G. V. Zaporozhets, and M. G. Feldman. "Investigation of the spawning sockeye salmon in the pool of the Nachikinskoe Lake (South-Western Kamchatka) with the help of a quadcopter in 2018." Researches of the aquatic biological resources of Kamchatka and the North-West Part of the Pacific Ocean 1, no. 56 (2020): 35–62. http://dx.doi.org/10.15853/2072-8212.2020.56.35-62.

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The Nachikinskoe Lake and its tributaries were first examined in detail with the help of a quadrocopter during running and spawning of early and late sockeye salmon. Quantitative estimates of adult salmon filling in different areas of lake tributaries and its coasts were obtained. The number of spring sockeye salmon was estimated at ~30 thous. specs, and late — at ~145 thous. specs (summation of adults counted every ~2 weeks) and 140 thous. specs (127–153 thous. specs), by means of imitation model. According to the photos from the quadrocopter, the boundaries of the spawning grounds of the lat
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38

He, Yong Jun. "Preparation of Novel Silica Nanoparticle/Polystyrene Composite Microspheres in a Pickering Emulsion." Advanced Materials Research 97-101 (March 2010): 2152–54. http://dx.doi.org/10.4028/www.scientific.net/amr.97-101.2152.

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Silica nanoparticle/polyaniline composite microspheres (SPCMs) were synthesized in a Pickering emulsion for the first time. The products were characterized by SEM and FTIR. The SPCMs were consisted of a polystryrene core and a silica nanoparticle shell. The average diameter of the SPCMs was about 3.3 μm. A mechanism for the formation of the SPCMs was discussed. The route reported here may be used for the preparation of other novel composite nanostructures.
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39

Arsi, Ranida, Sri Rejeki, and Achmad Zulfa Juniarto. "Endorphin, Oxytocin, And Suggestive Massage Stimulation (SPEOS) Methods In Increasing Breast Milk Production In Postpartum Mothers." Media Keperawatan Indonesia 4, no. 2 (2021): 140. http://dx.doi.org/10.26714/mki.4.2.2021.140-148.

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Postpartum pain and fatigue, impaired mobility, motivation, and psychological disorders of mother cause disturbances in the excretion of the breast which have an impact on the health of mother and baby. The SPEOS (Endorphin, Oxytocin, and Suggestive Massage Stimulation) methods is an alternative to help increase breastfeeding that combination of endorphin, oxytocin, and suggestive massage stimulation carried out sequentially which will feel the relaxation that stimulates the brain to release endorphin, prolactin and oxytocin hormones so that breast milk becomes smooth. The objective of this st
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40

Paradesi, Deivanayagam, Sivasubramanian Gandhimathi, Hariharasubramanian Krishnan, and Ramaswamy Jeyalakshmi. "A novel proton conducting polymer electrolyte membrane for fuel cell applications." High Performance Polymers 30, no. 1 (2017): 116–25. http://dx.doi.org/10.1177/0954008316684931.

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A series of phenolphthalein-based sulfonated poly(ether ether sulfone) (SPEES) membranes were synthesized by aromatic nucleophilic polymerization reaction. The degree of sulfonation was controlled by direct synthesis of sulfonated polymer, which leads to high thermal stability. The physicochemical properties of the SPEES membranes were studied in order to evaluate the suitability of these membranes in fuel cell applications. The ion-exchange capacity of the synthesized SPEES membranes was found in the range between 2.19 mequiv. g−1 and 2.35 mequiv. g−1. The morphology of the membranes was inve
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41

Phillips, Peter. "Gaudium et Spes." Journal of Catholic Social Thought 13, no. 2 (2016): 245–59. http://dx.doi.org/10.5840/jcathsoc20161327.

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42

&NA;. "PC-SPES overdose." Reactions Weekly &NA;, no. 875 (2001): 10. http://dx.doi.org/10.2165/00128415-200108750-00035.

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43

Louw, Daniel J. "Fides Quaerens Spem." Interpretation: A Journal of Bible and Theology 57, no. 4 (2003): 384–97. http://dx.doi.org/10.1177/002096430005700404.

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44

Pouresmaeel-Selkjani, Peyman, Mohsen Jahanshahi, and Majid Peyravi. "Mechanical, thermal, and morphological properties of nanoporous reinforced polysulfone membranes." High Performance Polymers 29, no. 7 (2016): 759–71. http://dx.doi.org/10.1177/0954008316656742.

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The effect of three different diphenols including 1,1′-thiobis(2-naphthol) (TBN), 2,2′-thiobis(4-methyl phenol) (TBMP) and curcumin (CUR) used in the preparation of sulfonated poly(ether sulfide sulfone) (SPESS) on the mechanical, thermal, and morphological properties of polysulfone (PSf) membranes was studied. In this regard, the morphological characteristics of the nanoporous membranes were explored by developed image analyzer program. Based on the obtained results, PSf membrane modified by SPESS-TBN copolymer showed the best nominal tensile strength in comparison to the other samples with t
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45

Sakhnini, Lama, and Maheen Dairi. "Orientation of sea urchin sperms in static magnetic fields: Compared to human sperms." Journal of Magnetism and Magnetic Materials 310, no. 2 (2007): e1035-e1037. http://dx.doi.org/10.1016/j.jmmm.2006.11.079.

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46

Langendijk, Henk, and Bart Van Praag. "De externe verslaggeving van Enron." Maandblad Voor Accountancy en Bedrijfseconomie 76, no. 6 (2002): 253–62. http://dx.doi.org/10.5117/mab.76.17494.

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Het doel van dit artikel is om de externe verslaggeving van Enron omtrent verbonden partijen, in het bijzonder de SPE’s, te behandelen en voorzover mogelijk te toetsen aan US GAAP. Hiertoe wordt in paragraaf 2 ingegaan op het fenomeen SPE, de criteria onder US GAAP om als SPE te kwalificeren en de toelichting die US GAAP vereist in het jaarrapport met betrekking tot verbonden partijen, in het bijzonder SPE’s. In paragraaf 3 wordt de werking van bepaalde transacties tussen Enron en enkele SPE’s behandeld, toegespitst op twee hoofdvormen: a. hedgetransacties Is door Enron voldaan aan de vereiste
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47

Wulandari, Risky Puji, and Mufdillah . "The Effect of Speos Method on the Quality of Postpartum Mother life at Mertoyudan I and Mertoyudan 2 Primary Health Center in 2018." Pakistan Journal of Medical and Health Sciences 15, no. 6 (2021): 1532–34. http://dx.doi.org/10.53350/pjmhs211561532.

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Background: Postpartum mothers are potentially susceptible to postpartum care complications, such as postpartum blues and depression. SPEOS is a combination of endorphin massage techniques, oxytocin massage, and positive suggestions to improve life quality after childbirth. Aim: This study aimed to prove the SPEOS method's effectiveness on postpartum mothers' quality of life. Methods: This research was a quasi-experiment with a pretest-posttest control group design. The research was conducted in Mertoyudan I Primary Health Center and Mertoyudan II Health Center. The research subjects were 22 p
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48

Raveney, Ben J. E., Wakiro Sato, Daiki Takewaki, et al. "Involvement of cytotoxic Eomes-expressing CD4+ T cells in secondary progressive multiple sclerosis." Proceedings of the National Academy of Sciences 118, no. 11 (2021): e2021818118. http://dx.doi.org/10.1073/pnas.2021818118.

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Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes of peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to a chronic disease course with progressive neurological dysfunctions (secondary progressive MS, SPMS), with the progression rate varying between patients and over time. SPMS pathogenesis is now linked to immune-cell–mediated processes, although the mechanisms driving SPMS transition and progression remain elusive,
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49

Wu, Kun Hong, and Fang Huang. "The Research on Adsorption of MB by SPES Microspheres and SPES Microspheres Wrapping Titanium Dioxide." Advanced Materials Research 1096 (April 2015): 237–42. http://dx.doi.org/10.4028/www.scientific.net/amr.1096.237.

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The polyethersulfone(PES) and sulfonated polyethersulfone(SPES) microspheres which all wraps titanium dioxide could be prepared by solvent evaporation method of double emulsion systems(W1/O/W2) or coagulation bath method. The results on the adsorption performance of methylene blue(MB) by PES and SPES microspheres wrapping titanium dioxide, SPES microspheres excluding titanium dioxide and the comparison of the isothermal and dynamic adsorption of SPES showed that, the adsorption performance of MB by SPES wrapping titanium dioxide is better than PES wrapping titanium dioxide, and the SPES exclud
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50

Luo, Ming Liang, Qing Zhi Wen, Hong Jian Liu, and Jia Lin Liu. "Effect of TiO2 Nanoparticles on the Hydrophilicity of Sulfonated-Polyethersulfone." Advanced Materials Research 79-82 (August 2009): 663–66. http://dx.doi.org/10.4028/www.scientific.net/amr.79-82.663.

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Sulfonated-polyethersulfone/TiO2 (SPES/TiO2) nanoparticle composites with different TiO2 content were prepared by a sol-gel process. These composites have nanosized TiO2 rich domains well dispersed within SPES matrix observed by SEM photograph. The effect of TiO2 nanoparticles on the hydrophilicity of SPES was discussed by contact angle goniometer. The mechanism of the hydrophilicity improvement of these composites was analyzed by the molecular interaction theory and FT-IR. The hydrogen bond and coordination bond between SPES and TiO2 nanoparticle were observed. Comparing with the pure SPES, t
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