Dissertations / Theses on the topic 'Spectroscopic imaging'
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Davidson, David William. "Imaging and spectroscopic radiation detectors." Thesis, University of Glasgow, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404443.
Full textWoods, Stephan M. "VIBRATIONAL SPECTROSCOPY AND SPECTROSCOPIC IMAGING OF BIOLOGICAL CELLS AND TISSUE." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1322540287.
Full textBao, Sumi. "Clinically relevant magnetic resonance imaging and spectroscopic imaging development." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/9133.
Full textIncludes bibliographical references (p. 129-137).
As one result of this thesis, a single slab 3D fast spin echo imaging (3DFSE) method has been implemented and optimized. This involved sequence design and implementation, SAR considerations, parameter adjustments and clinical testing. The method can deliver 3D Tl or T2 weighted brain image with isotropic Imm3 voxel resolution in approximately 10 minutes. The ability to obtain high spatial resolution in reasonable time periods has wide clinical applications such as improvement of treatment planning protocols for brain tumor patients, precise radiotherapy planning, and tissue segmentation for following the progression of diseases like multiple sclerosis. The other part of this thesis is devoted to developing and implementing spectroscopic imaging methods, which include 20 chemical shift imaging(2DCSI) methods, 20 line scan spectroscopic imaging(2D LSSI) methods, spin echo planar spectroscopic imaging(SEPSI) methods and ~ingle shot line scan spin echo planar spectroscopic imaging(SSLSEPSI) method. The former two methods are applied to oil phantoms and bone marrow studies. The SEPSI method can provide simultaneous spectroscopic measurements, R2 and R2' images and field distribution images. A time domain spectral analysis method, LP-HSVD was implemented and applied to spectroscopic imaging studies. The SEPSI method was applied to get lipid characterization of bone marrow as well as to get the R2 and R2' brain images. The SSLSEPSI method can provide instant line spectroscopic imaging which might be useful to image moving objects and can provide high temporal resolution for dynamic studies. With further development, both SEPSI and SSLSEPSI methods may prove useful for trabecular bone studies as well as functional magnetic resonance imaging( tMRI) studies.
by Sumi Bao.
Ph.D.
Paul, Provakar. "Multipoint spectroscopic analyzing & imaging method." Thesis, Högskolan i Gävle, Avdelningen för elektronik, matematik och naturvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-15274.
Full textLau, Condon. "Detecting cervical dysplasia with quantitative spectroscopic imaging." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/106718.
Full textIncludes bibliographical references.
This thesis extends quantitative spectroscopy, a form of model-based reflectance and fluorescence spectroscopy, from a small area, contact-probe implementation to wide-area quantitative spectroscopic imaging (QSI) for complete coverage of at-risk tissue. QSI uses the scanning virtual probe concept that is critical for model-based spectroscopy and offers spatial resolution advantages over conventional wide-field illumination. We develop a QSI system capable of imaging cervical dysplasia in vivo. Using the QSI system, we conduct a clinical study to train and prospectively evaluate QSI's ability to distinguish high-grade squamous intraepithelial lesions (HSIL) from non-HSILs (less severe conditions) in cervical transformation zone. This is a clinically important distinction because HSIL requires treatment. The results show measuring the per-patient normalized reduced scattering coefficient alone accurately performs the distinction. This is in good agreement with our previous contact-probe study of HSIL. Due to improved accuracy, QSI used as an adjunct to colposcopy can potentially reduce the number of unnecessary biopsies over colposcopy alone. The results also suggest a simplified optical instrument can be used to detect HSIL and this may advance cervical dysplasia detection in developing countries, where cervical cancer mortality is highest.
by Condon Lau.
Ph.D.
Meng, Jiqun J. "Line scan proton magnetic resonance spectroscopic imaging." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/36963.
Full textForsyth, Robert J. "Spectroscopic and imaging studies of nightglow variations." Thesis, University of Aberdeen, 1989. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU020230.
Full textLi, Zhenghong. "The role of the counter rotating terms in spontaneous emission and the time evolution of lamb shift." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1419.
Full textLi, Jianping. "High-resolution UV-Vis-NIR fourier transform imaging spectroscopy and its applications in biology and chemistry." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1151.
Full textPopa, Emil Horia. "Algorithms for handling arbitrary lineshape distortions in Magnetic Resonance Spectroscopy and Spectroscopic Imaging." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00716176.
Full textKok, Trina. "Magnetic resonance spectroscopic imaging with 2D spectroscopy for the detection of brain metabolites." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78450.
Full textCataloged from PDF version of thesis. Page 94 blank.
Includes bibliographical references (p. 87-93).
While magnetic resonance imaging (MRI) derives its signal from protons in water, additional biochemical compounds are detectable in vivo within the proton spectrum. The detection and mapping of these much weaker signals is known as magnetic resonance spectroscopy or spectroscopic imaging. Among the complicating factors for this modality applied to human clinical imaging are limited chemical-shift dispersion and J-coupling, which cause spectral overlap and complicated spectral shapes that limit detection and separation of brain metabolites using MR spectroscopic imaging (MRSI). Existing techniques for improved detection include so-called 2D spectroscopy, where additional encoding steps aid in the separation of compounds with overlapping chemical shift. This is achieved by collecting spectral data over a range of timing parameters and introducing an additional frequency axis. While these techniques have been shown to improve signal separation, they carry a penalty in scan time that is often prohibitive when combined with MRSI. Beyond scan time constraints, the lipid signal contamination from the subcutaneous tissue in the head pose problems in MRSI. Due to the large voxel size typical in MRSI experiments, ringing artifacts from lipid signals become more prominent and contaminate spectra in brain tissue. This is despite the spatial separation of subcutaneous and brain tissue. This thesis first explores the combination of a 2D MRS method, _Constant Time Point REsolved SpectroScopy (CT-PRESS) with fast spiral encoding in order to achieve feasible scan times for human in-vivo scanning. Human trials were done on a 3.OT scanner and with a 32-channel receive coil array. A lipid contamination minimization algorithm was incorporated for the reduction of lipid artifacts in brain metabolite spectra. This method was applied to the detection of cortical metabolites in the brain and results showed that peaks of metabolites, glutamate, glutamine and N-acetyl-aspartate were recovered after successful lipid suppression. The second task of this thesis was to investigate under-sampling in the indirect time dimension of CT-PRESS and its associated reconstruction with Multi-Task Bayesian Compressed Sensing, which incorporated fully-sampled simulated spectral data as prior information for regularization. It was observed that MT Bayesian CS gave good reconstructions despite simulated incomplete prior knowledge of spectral parameters.
by Trina Kok.
Ph.D.
Fernandez, Daniel Celestino. "Fourier-transform infrared spectroscopic imaging of prostate histopathology." [Tampa, Fla.] : University of South Florida, 2003. http://purl.fcla.edu/fcla/etd/SFE0000617.
Full textChan, Ka Lung Andrew. "Spectroscopic imaging of polymeric materials and pharmaceutical formulations." Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11974.
Full textAmrania, Hemmel. "Ultrafast Mid-Infrared Spectroscopic Imaging with Biomedical Applications." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526408.
Full textChatnuntawech, Itthi. "Model-based reconstruction of magnetic resonance spectroscopic imaging." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82376.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 77-80).
Magnetic resonance imaging (MRI) is a medical imaging technique that is used to obtain images of soft tissue throughout the body. Since its development in the 1970s, MRI has gained tremendous importance in clinical practice because it can produce high quality images of diagnostic value in an ever expanding range of applications from neuroimaging to body imaging to cancer. By far the dominant signal source in MRI is hydrogen nuclei in water. The presence of water at high concentration (-50M) in body tissue, combined with signal contrast modulation induced by the local environment of water molecules, accounts for the success of MRI as a medical imaging modality. As opposed to conventional MRI, which derives its signal from the water component, magnetic resonance spectroscopy (MRS) acquires the magnetic resonance signal from other chemical components, most frequently various metabolites in the brain, but also signals from tumors in breast and prostate. The spectroscopic signal arises from low concentration (-1 - 10mM) compounds, but in spite of the challenges posed by the resulting low signal-to-noise ratio (SNR), the development of MRS is motivated by the desire to directly observe signal sources other than water. The combination of MRS with spatial encoding is called magnetic resonance spectroscopic imaging (MRSI). MRSI captures not only the relative intensities of metabolite signals at each voxel, but also their spatial distributions. While MRSI has been proven to be clinically useful, it suffers from fundamental tradeoffs due to the inherently low SNR, such as long acquisition time and low spatial resolution. In this thesis, techniques that combine benefits from both model-based reconstruction methods and regularized reconstructions with prior knowledge are proposed and demonstrated for MRSI. These methods address constraints on acquisition time in MRSI by undersampling data during acquisition in combination with improved image reconstruction methods.
by Itthi Chatnuntawech.
S.M.
Glassford, Stefanie Elizabeth. "Applications of ATR-FTIR spectroscopic imaging to proteins." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24835.
Full textYeo, Woon Gi. "Terahertz Spectroscopic Characterization and Imaging for Biomedical Applications." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1430825935.
Full textGu, Meng. "High-speed volumetric ¹H magnetic resonance spectroscopic imaging /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textParikh, Jehill. "Measurement of brain temperature using magnetic resonance spectroscopic imaging." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8082.
Full textAlkhatib, Fatmah Mohammad. "A spectroscopic and imaging investigation of sporopollenin-metal interactions." Thesis, University of Hull, 2017. http://hydra.hull.ac.uk/resources/hull:16526.
Full textSawbridge, Rebecca Joanne. "Developments in magnetic resonance spectroscopic imaging acquisition and analysis." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8050/.
Full textGagoski, Borjan Aleksandar. "Fast magnetic resonance spectroscopic imaging using RF coil arrays." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37930.
Full textIncludes bibliographical references (p. 71-73).
Conventional Magnetic Resonance Spectroscopic Imaging (MRSI) suffers from both low signal-to-noise (SNR), as well as long acquisition times. The development of high-fidelity gradient coils has opened opportunities for fast k-space encoding schemes that are already used in structural imaging. At the same time, receive-coil arrays using 4 and 23 channels have been developed and reported to produce improved SNR over conventional quadrature detection by single coils. Fast spectroscopic imaging algorithm using spiral k-space trajectories and multiple-channel coil arrays is proposed in order to overcome the long acquisition-time limitations of conventional MRSI.
by Borjan Aleksandar Gagoski.
S.M.
Lee, Joonsung. "Excitation and readout Designs for high field spectroscopic imaging." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/64578.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 86-90).
In this thesis we state and demonstrate solutions to three engineering problems that arise in magnetic resonance imaging RF excitation with parallel transmission (pTx) and magnetic resonance spectroscopic imaging (MRSI). Recent work in parallel RF excitation in MRI has been demonstrated to offer dramatically improved flexibility for manipulation of magnetization preparation for imaging than is feasible with conventional single-channel transmission. We address two design problems that need to be solved before this emerging technology can be deployed in the clinical and research domain of human imaging at high field. First, we demonstrate a method for rapid and robust acquisition of the non-uniform fields of RF excitation due to arrays that are commonly used in pTx at high field. Our method achieves high-fidelity single-slice excitation and reception field mapping in 20 seconds, and we propose ways to extend this to multi-slice mapping in two minutes for twenty slices. A fundamental constraint to the application of pTx is the management of the deposition of power in human tissue, quantified by the specific absorption rate (SAR). The complex behavior of the spatial distribution of SAR in transmission arrays poses problems not encountered in conventional single-channel systems, and we propose a pTx design method to incorporate local SAR constraints within computation times that accommodate pTx pulse design during MRI acquisition of human subjects. Our approach builds on recent work to capture local SAR distribution with much lower computational complexity than a brute-force evaluation, and we demonstrate that this approach can reduce peak local SAR by 20~40% for commonly applied pTx design targets. This thesis focuses on the design of excitation methods for high field system (7T parallel transmit (pTx) system) and fast readout and post-processing methods to reduce the lipid contamination to the brain. The contributions include fast B1+ mapping and pTx RF pulse design with the local SAR constraints for excitation. Regarding the readout method we developed a real time filter design, variable density spiral trajectory, and iterative non-linear reconstruction technique that reduce the lipid contamination. The proposed excitation methods were demonstrated using a 7T pTx system and the readout methods were implemented in a 3T system. Our third contribution addresses a recurring problem in MRSI of the brain, namely strong contaminating artifacts in low signal-to-noise ratio brain metabolite maps due to subcutaneous, high-concentration lipid sources. We demonstrate two methods to address this problems, one during the acquisition stage where a spatial filter is designed based on spatial priors acquired from the subject being scanned, and the second is a post-processing method that applies the brain and lipid source prior for further artifact minimization. These methods are demonstrated to achieve 20~4OdB enhancement of lipid suppression in brain MRSI of human subjects.
by Joonsung Lee.
Ph.D.
Boswell, C. J. (Christopher James) 1974. "Visible spectroscopic imaging on the Alcator C-Mod tokamak." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/16600.
Full textIncludes bibliographical references (p. 155-161).
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
This dissertation reports on the development of a diagnostic visible imaging system on the Alcator C-Mod tokamak and the results from that system. The dissertation asserts the value of this system as a qualitative and quantitative diagnostic for magnetically confined plasmas. The visible imaging system consists of six CCD cameras, absolutely calibrated and filtered for specific spectral ranges. Two of these cameras view the divertor region tangentially, two view RF antenna structures and two are used for a wide-angle survey of the vacuum vessel. The divertor viewing cameras are used to generate two-dimensional emissivity profiles using tomography. Three physics issues have been addressed using the visible imaging system: 1) Using two-dimensional emissivity profiles of Da, volumetric recombination rate profiles have been measured and found to have a structure that depends on a poloidal temperature gradient in the outer scrape-off-layer. 2) A camera viewing the inner wall tangentially was used to measure Da emission profiles. A sharp break in slope of the radial density profile was found at the location of the secondary separatrix near the inner wall by using these profiles and a kinetic model of the neutrals. 3) Two-dimensional emissivity profiles of visible continuum (420-430nm) have been measured and found to be an order of magnitude too large when compared to expected levels from electron-ion bremsstrahlung and radiative recombination. Several atomic and molecular processes have been considered to explain the enhanced continuum. However, none of the considered processes could explain the continuum level without particle densities inconsistent with current modeling efforts.
(cont.) The visible imaging system was also used in identifying the causes of impurity injections during discharges, in identifying the failure of invessel components, and as a monitor of vessel and plasma conditions. Both the physics results and the operational benefits of the visible imaging system show that the system is a valuable quantitative and qualitative diagnostic.
by Christopher James Boswell.
Ph.D.
Gagoski, Borjan Aleksandar. "Magnetic resonance spectroscopic imaging using parallel transmission at 7T." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/63069.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 123-130).
Conventional magnetic resonance spectroscopic imaging (MRSI), also known as phase-encoded (PE) chemical shift imaging (CSI), suffers from both low signal-to-noise ratio (SNR) of the brain metabolites, as well as inflexible tradeoffs between acquisition time and spatial resolution. In addition, although CSI at higher main field strengths, e.g. 7 Tesla (T), offers improved SNR over clinical 1.5T or 3.OT scanners, the realization of these benefits is limited by severe inhomogeneities of the radio frequency (RF) excitation magnetic field (B,+), which is responsible for significant signal variation within the volume of interest (VOI) resulting in spatially dependent SNR losses. The work presented in this dissertation aims to provide the necessary means for using spectroscopic imaging for reliable and robust whole brain metabolite detection and quantification at high main field strengths. It addresses the challenges mentioned above by improving both the excitation and the readout components of the CSI acquisition. The long acquisition times of the PE CSI are significantly shortened (at least 20 fold) by implementing the time-efficient spiral CSI algorithm, while the B1 non-uniformities are corrected for using RF pulses designed for new RF excitation hardware at 7T, so-called parallel transmission (pTx). The B1 homogeneity of the pTx excitations improved at least by a factor of 4 (measured by the normalized spatial standard deviations) compared to conventional single channel transmit systems. The first contribution of this thesis describes the implementation of spiral CSI algorithm for online gradient waveform design and spectroscopic image reconstruction with standard clinical excitation protocols and applied in studies of Late-Onset Tay- Sachs (LOTS), adrenoleukodystrophy (ALD) and brain tumors. A major contribution of this thesis is pTx excitation design for CSI to provide spectral-spatial mitigation of the B1+ inhomogeneities at 7T. Novel pTx RF designs are proposed and demonstrated to yield excellent flip angle mitigation of the brain metabolites, and also enable improved suppression of the undesired water and lipid signals. A major obstacle to the deployment of 7T pTx applications for clinical imaging is the monitoring and management of local specific absorption rate (SAR). This thesis also proposes a pTx SAR monitoring system with real-time RF monitoring and shut-off capabilities.
by Borjan Aleksandar Gagoski.
Ph.D.
Wild, James Michael. "Proton magnetic resonance spectroscopic imaging of the human brain." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/22742.
Full textBILHORN, ROBERT BYERS. "ANALYTICAL SPECTROSCOPIC CAPABILITIES OF OPTICAL IMAGING CHARGE TRANSFER DEVICES." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184186.
Full textDzien, Piotr. "The development of novel tools for in vivo molecular imaging using hyperpolarised ¹³C labelled molecules and ¹³C magnetic resonance spectroscopy and spectroscopic imaging." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708714.
Full textMalamas, Sitthichai. "Spectroscopic imaging with uncooled microbolometer camera and step-scan FTIR." Thesis, Monterey, Calif. : Naval Postgraduate School, 2006. http://bosun.nps.edu/uhtbin/hyperion.exe/06Dec%5FMalamas.pdf.
Full textThesis Advisor(s): Gamani Karunasiri, D. Scott Davis. "December 2006." Includes bibliographical references (p. 37). Also available in print.
Earnhart, Jonathan Raby. "A Compton Camera for Spectroscopic Imaging from 100keV to 1MeV." NCSU, 1999. http://www.lib.ncsu.edu/theses/available/etd-19990507-170013.
Full textEarnhart, Jonathan Raby Dewitt. A Compton Camera for Spectroscopic Imaging from 100keV to 1MeV (Under the direction of Robin Gardner and Thomas Prettyman).
Compton cameras are a particularly interesting gamma-ray imaging technology because they have a large field of view and rely on electronic rather than mechanical collimation (lead). These systems produce two dimensional, spectroscopic images using data collected from spatially separated detector arrays. A single acquisition contains data to produce image signatures for each radionuclide in the field of view. Application of Compton cameras in field of astrophysics has proven the systems capability for imaging in the 1 to 30MeV range. Other potential applications, in the 100keV to 1MeV range, include nuclear material safeguards and nuclear medicine imaging. A particularly attractive feature for these applications is that the technology to produce a portable camera is now available due to improvements in solid state room-temperature detectors.
The objective of this work is to investigate Compton camera technology for spectroscopic imaging of gamma rays in the 100keV to 1MeV range. To this end, accurate and efficient camera simulation capability will allow a variety of design issues to be explored before a full camera system is built. An efficient, specific purpose Monte Carlo code was developed to investigate the image formation process in Compton cameras. The code is based on a pathway sampling technique with extensive use of variance reduction techniques. In particular, the technique of forcing is used make each history result in a partial success. The code includes detailed Compton scattering physics, including incoherent scattering functions, Doppler broadening, and multiple scattering. Detector response functions are also included in the simulations.
A prototype camera was built to provide code benchmarks and investigate implementation issues. The prototype is based on a two-detector system, which sacrifices detection efficiency for simplicity and versatility. One of the detectors is mounted on a computer controlled stage capable of two dimensional motion (14x14cm full range with ±0.1mm precision). This produces a temporally encoded image via motion of the detector.
Experiments were performed with two different camera configurations for a scene containing a 75Se source and a 137Cs source. These sources provided a challenging test of the spectroscopic imaging capability of the Compton camera concept. The first camera was based on a fixed silicon detector in the front plane and a CdZnTe detector mounted in the stage. The second camera configuration was based on two CdZnTe detectors. Both systems were able to reconstruct images of 75Se, using the 265keV line, and 137Cs, using the 662keV line. Only the silicon-CdZnTe camera was able to resolve the low intensity 400keV line of 75Se. Neither camera was able to reconstruct the 75Se source location using the 136keV line. The camera has a low energy limit imposed by the noise level on the front plane detector's timing signal. The timing performance of the coplanar grid CdZnTe detector design was improved, resulting in a reduction in the full width half maximum of the coincidence timing peak between two detectors from 800ns to 30ns.
The energy resolution of the silicon-CdZnTe camera system was 4% at 662keV. This camera reproduced the location of the 137Cs source by event circle image reconstruction with angular resolutions of 10° for a source on the camera axis and 14° for a source 30° off axis. The source to camera distance was approximately 1m. Typical detector pair efficiencies were measured as 3x10-11 at 662keV.
The dual CdZnTe camera had an energy resolution of 3.2% at 662keV. This camera reproduced the location of the 137Cs source by event circle image reconstruction with angular resolutions of 8° for a source on the camera axis and 12° for a source 20° off axis. The source to camera distance was 1.7m. Typical detector pair efficiencies were measured as 7x10-11 at 662keV.
Of the two prototype camera configurations tested, the silicon-CdZnTe configuration had superior imaging characteristics. This configuration is less sensitive to effects caused by source decay cascades and random coincident events. An implementation of the expectation maximum-maximum likelihood reconstruction technique improved the angular resolution to 6° and reduced the background in all the images.
The measured counting rates were a factor of two low for the silicon-CdZnTe camera, and up to a factor of four high for the dual CdZnTe camera compared to simulation. These differences are greater than the error bars. The primary reasons for these discrepancies are related to experimental conditions imposed by source decay cascades and the occurrence of random coincidences which are not modeled by the code.
Chen, Wen-Lung. "Raman spectroscopic/imaging studies of eye lenses and lens proteins." Diss., Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/30431.
Full textKimber, James A. "Mathematical modelling and FTIR spectroscopic imaging of pharmaceutical tablet dissolution." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9301.
Full textEwing, Andrew. "ATR-FTIR spectroscopic imaging to study drug release and tablet dissolution." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/51556.
Full textWorthington, Lara Angharad. "Investigation of compressed-sensing for acceleration of magnetic resonance spectroscopic imaging." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6128/.
Full textFerguson, Leesa Susanne. "Analysis of the composition of latent fingermarks by spectroscopic imaging techniques." Thesis, Sheffield Hallam University, 2013. http://shura.shu.ac.uk/19645/.
Full textWray, Patrick S. "Spectroscopic imaging of the compaction and dissolution of model pharmaceutical formulations." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9074.
Full textLi, Yan. "Multi-dimensional MR spectroscopic imaging of gliomas at different field strengths." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311329.
Full textSource: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3694. Adviser: Sarah J. Nelson.
Laruelo, Fernandez Andrea. "Integration of magnetic resonance spectroscopic imaging into the radiotherapy treatment planning." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30126/document.
Full textThe aim of this thesis is to propose new algorithms to overcome the current limitations and to address the open challenges in the processing of magnetic resonance spectroscopic imaging (MRSI) data. MRSI is a non-invasive modality able to provide the spatial distribution of relevant biochemical compounds (metabolites) commonly used as biomarkers of disease. Information provided by MRSI can be used as a valuable insight for the diagnosis, treatment and follow-up of several diseases such as cancer or neurological disorders. Obtaining accurate and reliable information from in vivo MRSI signals is a crucial requirement for the clinical utility of this technique. Despite the numerous publications on the topic, the interpretation of MRSI data is still a challenging problem due to different factors such as the low signal-to-noise ratio (SNR) of the signals, the overlap of spectral lines or the presence of nuisance components. This thesis addresses the problem of interpreting MRSI data and characterizing recurrence in tumor brain patients. These objectives are addressed through a methodological approach based on novel processing methods that incorporate prior knowledge on the MRSI data using a spatio-spectral regularization. As an application, the thesis addresses the integration of MRSI into the radiotherapy treatment workflow within the context of the European project SUMMER (Software for the Use of Multi-Modality images in External Radiotherapy) founded by the European Commission (FP7-PEOPLE-ITN framework)
Smith, P. G. R. "Spectroscopic and imaging aspects of degenerate four-wave mixing for combustion diagnostics." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239399.
Full textGu, Min. "Raman Mode-Selective Spectroscopic Imaging of Redox State in FMN and Flavoprotein." Bowling Green State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1398866391.
Full textGudmundson, Erik. "Signal Processing for Spectroscopic Applications." Doctoral thesis, Uppsala universitet, Avdelningen för systemteknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120194.
Full textMüller, Christoph Alexander [Verfasser], and Jürgen [Akademischer Betreuer] Hennig. "Real-time metabolic imaging of pyruvate and lactate using hyperpolarised 13C magnetic resonance spectroscopic imaging with ME-bSSFP : : a method of clinical cancer imaging." Freiburg : Universität, 2020. http://d-nb.info/1226091237/34.
Full textHu, Simon. "Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: Pulse sequence development for compressed sensing rapid imaging and preclinical liver studies." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390048.
Full textSource: Dissertation Abstracts International, Volume: 71-02, Section: B, page: . Adviser: Daniel B. Vigneron.
Heffer, Erica Leigh. "Frequency-domain optical mammography for detection and oximetry of breast tumors /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.
Find full textAdviser: Sergio Fantini. Submitted to the Dept. of Electrical Engineering. Includes bibliographical references (leaves 201-202). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
Boatwright, Mark Daniel. "Near infrared quantitative chemical imaging as an objective, analytical tool for optimization of the industrial processing of wheat." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38430.
Full textBiochemistry and Molecular Biophysics Interdepartmental Program
John M. Tomich
David L. Wetzel
The technique of near infrared chemical imaging has been widely used for many industrial applications. It offers selectivity and/or sensitivity for numerous organic functional groups. The advantage of the near infrared spectroscopic region is the linear relationship of absorbance and concentration that enables quantitation. This universally employed technique has been a boon for research studies in the industrial process of wheat milling for the production of flour. The milling process has numerous sequential grinding and sieving steps that enable selective physical segregation of a starch rich endosperm product from wheat. Thousands of spectra of purified endosperm and non-endosperm standards are collected to develop a spectral library. Quantitation of the purity of individual processing streams is accomplished by applying a partial least squares calibration that is based upon the spectral library. The quantitative chemical imaging technique is useful for determination of endosperm purity profiles for mill flour streams. These plots reveal purity changes as less pure streams are added to produce a flour blend. The chemical structural basis furthermore allows comparison of purity even with changes in the wheat blend being milled with representative standardization. Furthermore, whereas a certain section of sieves is responsible, for designating the material defined as flour, application of the spectroscopic method is obvious. Select examples of key processing streams were studied to show the possibility of sieve-by-sieve analysis of the physical separation to provide mill optimization. These novel methods of analysis would not be possible without the sensitive and selective method of quantitative chemical imaging. Application of this technique to a few select unit processes is projected to reasonably affect a 1% increase in the yield of high quality flour. This amounts to a significant financial gain against low profit margins.
Mehta, Manoj. "Spectroscopic imaging and molecular profiling of atherosclerosis : an insight into the aortic condition." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412529.
Full textFindlay, Joanna Edyta. "Phase transitions and mesophases in molecular liquids and solutions : spectroscopic and imaging studies." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8531/.
Full textFoose, Daniel Patrick. "Vespucci: A free, cross-platform software tool for spectroscopic data analysis and imaging." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472823712.
Full textSilwal, Achut Prasad. "Raman Spectroscopic Imaging Analysis of Signaling Proteins and Protein Cofactors in Living Cells." Bowling Green State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1528721394633565.
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