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1

Nasonova, Tetiana, Tetiana Kolosova, Danylo Briakin, Natalia Mykhailovska, Igor Kurochkin, Tetiana Riabychenko, Olena Tyshkevych, Yurii Buhaiov, Yurii Holovchenko, and Valeriia Hushcha. "Neglect syndrome after ischemic stroke: diagnosis, treatment options." Ukrains'kyi Visnyk Psykhonevrolohii 27, no. 2 (99) (June 10, 2019): 8–14. http://dx.doi.org/10.36927/2079-0325-v27-is2-2019-2.

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The purpose of the study: the study of clinical efficacy and safety of the Neuromidin® in the rehabilitation period in patients with primary ischemic stroke, its eff ect on motor, cognitive function, level of household adaptation, depending on the presence or absence of neglekt syndrome and "push-syndrome". 60 patients aged 49 to 82 years in the recovery period of ischemic stroke were examined (30 patients — the main group: treatment with the addition of Neuromidin®; 30 patients — control group: standard treatment without adding Neuromidin®). Investigation of motor, cognitive, and sensitive disorders was carried out with the use of clinical scales. The effectiveness of the treatment was evaluated in the absence of signs of neglekt syndrome and "push-syndrome", reduction of motor and cognitive impairment. Patients with neglekt syndrome showed greater dependence on third-party care and more severe cognitive impairment than in patients who had not been diagnosed neglekt syndrome. After treatment, the majori ty of patients achieved elimination of neglekt syndrome, but in the group where patients received Neuromidin®, the number of such patients was higher. In addition, patients in the main group improved cognitive function. The use of Neuromidin® in complex rehabilitation measures in patients with ischemic stroke contributes to the restoration of lost functions, reduces the phenomena of visual-spatial neglect, positively affects self-care and improves the quality of life of patients and their relatives.
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2

Silver, Bernie. "Spatial Neglect." Journal of Head Trauma Rehabilitation 16, no. 6 (December 2001): 613–14. http://dx.doi.org/10.1097/00001199-200112000-00011.

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3

Li, Korina, and Paresh A. Malhotra. "Spatial neglect." Practical Neurology 15, no. 5 (May 28, 2015): 333–39. http://dx.doi.org/10.1136/practneurol-2015-001115.

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4

Kirk, Andrew. "Spatial neglect." Current Neurology and Neuroscience Reports 1, no. 6 (November 2001): 541–46. http://dx.doi.org/10.1007/s11910-001-0059-x.

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5

Maeda, Masaharu. "Unilateral spatial neglect." Higher Brain Function Research 28, no. 2 (2008): 214–23. http://dx.doi.org/10.2496/hbfr.28.214.

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6

Mark, V. W., and K. M. Heilman. "Diagonal spatial neglect." Journal of Neurology, Neurosurgery & Psychiatry 65, no. 3 (September 1, 1998): 348–52. http://dx.doi.org/10.1136/jnnp.65.3.348.

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7

Ishiai, Sumio. "Unilateral spatial neglect." Neuropsychological Rehabilitation 4, no. 2 (June 1994): 143–46. http://dx.doi.org/10.1080/09602019408402272.

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8

Swan, Laurie. "Unilateral Spatial Neglect." Physical Therapy 81, no. 9 (September 1, 2001): 1572–80. http://dx.doi.org/10.1093/ptj/81.9.1572.

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9

Shimizu, Taro, Tomoya Abe, Yasutoshi Akasaki, and Hideaki Kamiishi. "Unilateral spatial neglect." BMJ Case Reports 13, no. 11 (November 2020): e239770. http://dx.doi.org/10.1136/bcr-2020-239770.

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10

Cubelli, Roberto. "Definition: Spatial neglect." Cortex 92 (July 2017): 320–21. http://dx.doi.org/10.1016/j.cortex.2017.03.021.

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11

Karnath, Hans-Otto. "Spatial attention systems in spatial neglect." Neuropsychologia 75 (August 2015): 61–73. http://dx.doi.org/10.1016/j.neuropsychologia.2015.05.019.

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12

Malhotra, P. A., D. Soto, K. Li, and C. Russell. "Reward modulates spatial neglect." Journal of Neurology, Neurosurgery & Psychiatry 84, no. 4 (October 15, 2012): 366–69. http://dx.doi.org/10.1136/jnnp-2012-303169.

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13

Posner, Michael I. "Neglect and spatial attention." Neuropsychological Rehabilitation 4, no. 2 (June 1994): 183–87. http://dx.doi.org/10.1080/09602019408402280.

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14

Cubelli, Roberto, Sergio Della Sala, Nicoletta Beschin, and Robert D. McIntosh. "Distance-mediated spatial neglect." Neurocase 20, no. 3 (April 3, 2013): 338–45. http://dx.doi.org/10.1080/13554794.2013.770885.

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15

L, A. "Dissociation of visuo-spatial neglect and neglect dyslexia." Neurocase 1, no. 3 (September 1, 1995): 209a—216. http://dx.doi.org/10.1093/neucas/1.3.209-a.

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16

Maeshima, Shinichiro. "Subclassification of unilateral spatial neglect." Higher Brain Function Research 26, no. 3 (2006): 235–44. http://dx.doi.org/10.2496/hbfr.26.235.

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17

Speedie, Lynn J., Eli Wertman, Mieke Verfaellie, Charles Butter, Nechama Silberman, Micky Liechtenstein, and Kenneth M. Heilman. "Reading Direction and Spatial Neglect." Cortex 38, no. 1 (January 2002): 59–67. http://dx.doi.org/10.1016/s0010-9452(08)70638-5.

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18

MIJOVIĆ, DANICA. "MECHANISMS OF VISUAL SPATIAL NEGLECT." Brain 114, no. 4 (1991): 1575–93. http://dx.doi.org/10.1093/brain/114.4.1575.

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19

Roux, Franck-Emmanuel, Olivier Dufor, Valérie Lauwers-Cances, Leila Boukhatem, David Brauge, Louisa Draper, Jean-Albert Lotterie, and Jean-François Démonet. "Electrostimulation Mapping of Spatial Neglect." Neurosurgery 69, no. 6 (June 28, 2011): 1218–31. http://dx.doi.org/10.1227/neu.0b013e31822aefd2.

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Abstract BACKGROUND Cortical and subcortical electrostimulation mapping during awake brain surgery for tumor removal is usually used to minimize deficits. OBJECTIVE To use electrostimulation to study neuronal substrates involved in spatial awareness in humans. METHODS Spatial neglect was studied using a line bisection task in combination with electrostimulation mapping of the right hemisphere in 50 cases. Stimulation sites were identified with Talairach coordinates. The behavioral effects induced by stimulation, especially eye movements and deviations from the median, were quantified and compared with preoperative data and a control group. RESULTS Composite and highly individualized spatial neglect maps were generated. Both rightward and leftward deviations were induced, sometimes in the same patient but for different stimulation sites. Group analysis showed that specific and reproducible line deviations were induced by stimulation of discrete cortical areas located in the posterior part of the right superior and middle temporal gyri, inferior parietal lobe, and inferior postcentral and inferior frontal gyri (P > .05). Fiber tracking identified stimulated subcortical areas important to spare as sections of fronto-occipital and superior longitudinal II fascicles. According to preoperative and postoperative neglect battery tests, the specificity and sensitivity of intraoperative line bisection tests were 94% and 83%, respectively. CONCLUSION In humans, discrete cortical areas that are variable in location between individuals but mainly located within the right posterior Sylvian fissure sustain visuospatial attention specifically toward the contralateral or ipsilateral space direction. Line bisection mapping was found to be a reliable method for minimizing spatial neglect caused by brain tumor surgery.
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20

Bowen, Audrey, Nadina B. Lincoln, and Michael E. Dewey. "Spatial Neglect: Is Rehabilitation Effective?" Stroke 33, no. 11 (November 2002): 2728–29. http://dx.doi.org/10.1161/01.str.0000035747.03607.1a.

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21

Karnath, Hans-Otto, and Christopher Rorden. "The anatomy of spatial neglect." Neuropsychologia 50, no. 6 (May 2012): 1010–17. http://dx.doi.org/10.1016/j.neuropsychologia.2011.06.027.

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22

Walker, Robin. "Spatial and object-based neglect." Neurocase 1, no. 4 (October 1995): 371–83. http://dx.doi.org/10.1080/13554799508402381.

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23

Karnath, Hans-Otto, and Marianne Dieterich. "Spatial neglect—a vestibular disorder?" Brain 129, no. 2 (December 21, 2005): 293–305. http://dx.doi.org/10.1093/brain/awh698.

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24

Vuilleumier, Patrik, and Theodor Landis. "Illusory contours and spatial neglect." NeuroReport 9, no. 11 (August 1998): 2481–84. http://dx.doi.org/10.1097/00001756-199808030-00010.

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25

Keller, Ingo, Jochen Ditterich, Thomas Eggert, and Andreas Straube. "Size distortion in spatial neglect." NeuroReport 11, no. 8 (June 2000): 1655–60. http://dx.doi.org/10.1097/00001756-200006050-00012.

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26

Corbetta, Maurizio, and Gordon L. Shulman. "Spatial Neglect and Attention Networks." Annual Review of Neuroscience 34, no. 1 (July 21, 2011): 569–99. http://dx.doi.org/10.1146/annurev-neuro-061010-113731.

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27

Hillis, Argye E. "Neurobiology of Unilateral Spatial Neglect." Neuroscientist 12, no. 2 (April 2006): 153–63. http://dx.doi.org/10.1177/1073858405284257.

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28

Terrell, Beth-Marie, Christine Towler, and A. M. Barrett. "Aphasia-accessible Spatial Neglect Care." Archives of Physical Medicine and Rehabilitation 101, no. 11 (November 2020): e32. http://dx.doi.org/10.1016/j.apmr.2020.09.090.

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29

Mizuno, Katsuhiro. "Rehabilitation for Unilateral Spatial Neglect." Japanese Journal of Rehabilitation Medicine 58, no. 1 (January 18, 2021): 53–58. http://dx.doi.org/10.2490/jjrmc.58.53.

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30

Rusconi, Maria Luisa, and Laura Carelli. "Long-Term Efficacy of Prism Adaptation on Spatial Neglect: Preliminary Results on Different Spatial Components." Scientific World Journal 2012 (2012): 1–8. http://dx.doi.org/10.1100/2012/618528.

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This study describes the long-term effectiveness on spatial neglect recovery of a 2-week treatment based on prism adaptation (PA). Seven right-brain-damaged patients affected by chronic neglect were evaluated before, after two weeks of the PA treatment and at a follow-up (variable between 8 and 30 months after the end of PA). Neglect evaluation was performed by means of BIT (conventional and behavioral), Fluff Test, and Comb and Razor Test. The results highlight an improvement, after the PA training, in both tasks performed using the hand trained in PA treatment and in behavioral tasks not requiring a manual motor response. Such effects extend, even if not significantly, to all BIT subtests. These results support previous findings, showing that PA improves neglect also on imagery tasks with no manual component, and provide further evidence for long-lasting efficacy of PA training. Dissociations have been found with regard to PA efficacy on peripersonal, personal, and representational neglect, visuospatial agraphia and neglect dyslexia. In particular, we found no significant differences between the pre-training and post-training PA session in personal neglect measures, and a poor recovery of neglect dyslexia after PA treatment. The recruitment of a larger sample could help to confirm the effectiveness of the prismatic lenses with regard to the different clinical manifestations of spatial neglect.
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31

Bonato, Mario, Arnaud Saj, and Patrik Vuilleumier. "Hemispatial Neglect Shows That “Before” Is “Left”." Neural Plasticity 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/2716036.

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Recent research has led to the hypothesis that events which unfold in time might be spatially represented in a left-to-right fashion, resembling writing direction. Here we studied fourteen right-hemisphere damaged patients, with or without neglect, a disorder of spatial awareness affecting contralesional (here left) space processing and representation. We reasoned that if the processing of time-ordered events is spatial in nature, it should be impaired in the presence of neglect and spared in its absence. Patients categorized events of a story as occurring before or after a central event, which acted as a temporal reference. An asymmetric distance effect emerged in neglect patients, with slower responses to events that took place before the temporal reference. The event occurring immediately before the reference elicited particularly slow responses, closely mirroring the pattern found in neglect patients performing numerical comparison tasks. Moreover, the first item elicited significantly slower responses than the last one, suggesting a preference for a left-to-right scanning/representation of events in time. Patients without neglect showed a regular and symmetric distance effect. These findings further suggest that the representation of events order is spatial in nature and provide compelling evidence that ordinality is similarly represented within temporal and numerical domains.
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32

Becchio, Cristina, and Cesare Bertone. "Time and neglect: Abnormal temporal dynamics in unilateral spatial neglect." Neuropsychologia 44, no. 14 (January 2006): 2775–82. http://dx.doi.org/10.1016/j.neuropsychologia.2006.06.011.

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33

Hillis, Argye E., Brenda Rapp, Lisa Benzing, and Alfonso Caramazza. "Dissociable Coordinate Frames of Unilateral Spatial Neglect: “Viewer-Centered” Neglect." Brain and Cognition 37, no. 3 (August 1998): 491–526. http://dx.doi.org/10.1006/brcg.1998.1010.

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34

Chen, Peii, Irene Ward, Ummais Khan, Yan Liu, and Kimberly Hreha. "Spatial Neglect Hinders Success of Inpatient Rehabilitation in Individuals With Traumatic Brain Injury." Neurorehabilitation and Neural Repair 30, no. 5 (September 3, 2015): 451–60. http://dx.doi.org/10.1177/1545968315604397.

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Background. Current knowledge about spatial neglect and its impact on rehabilitation mostly originates from stroke studies. Objective. To examine the impact of spatial neglect on rehabilitation outcome in individuals with traumatic brain injury (TBI). Methods. The retrospective study included 156 consecutive patients with TBI (73 women; median age = 69.5 years; interquartile range = 50-81 years) at an inpatient rehabilitation facility (IRF). We examined whether the presence of spatial neglect affected the Functional Independence Measure (FIM) scores, length of stay, or discharge disposition. Based on the available medical records, we also explored whether spatial neglect was associated with tactile sensation or muscle strength asymmetry in the extremities and whether specific brain injuries or lesions predicted spatial neglect. Results. In all, 30.1% (47 of 156) of the sample had spatial neglect. Sex, age, severity of TBI, or time postinjury did not differ between patients with and without spatial neglect. In comparison to patients without spatial neglect, patients with the disorder stayed in IRF 5 days longer, had lower FIM scores at discharge, improved slower in both Cognitive and Motor FIM scores, and might have less likelihood of return home. In addition, left-sided neglect was associated with asymmetric strength in the lower extremities, specifically left weaker than the right. Finally, brain injury–induced mass effect predicted left-sided neglect. Conclusions. Spatial neglect is common following TBI, impedes rehabilitation progress in both motor and cognitive domains, and prolongs length of stay. Future research is needed for linking specific traumatic injuries and lesioned networks to spatial neglect and related impairment.
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35

Saj, Arnaud, Juliane C. Wilcke, Markus Gschwind, Héloïse Emond, and Frédéric Assal. "Spatial Hyperschematia without Spatial Neglect after Insulo-Thalamic Disconnection." PLoS ONE 8, no. 11 (November 26, 2013): e79938. http://dx.doi.org/10.1371/journal.pone.0079938.

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36

Kerkhoff, Georg, Frank Artinger, and Wolfram Ziegler. "Contrasting spatial hearing deficits in hemianopia and spatial neglect." NeuroReport 10, no. 17 (November 1999): 3555–60. http://dx.doi.org/10.1097/00001756-199911260-00017.

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37

Chen, Xiao-Wei, Cheng-He Lin, Hua Zheng, and Zhen-Lan Lin. "A Chinese Patient with Pusher Syndrome and Unilateral Spatial Neglect Syndrome." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 41, no. 4 (July 2014): 493–97. http://dx.doi.org/10.1017/s0317167100018540.

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Objective:To observe clinical manifestations, behavioral characteristics, and effects of rehabilitation on a patient with pusher syndrome and unilateral spatial neglect caused by right thalamic hemorrhage.Methods:Assessment of pusher syndrome was made by the Scale for Contraversive pushing (SCP), and unilateral spatial neglect syndrome was diagnosed using line cancellation, letter and star cancellation, line bisection tests and copy and continuation of graphic sequence test. Behavioral therapy, occupational therapy, reading training and traditional Chinese medicine methods were adopted for treatment of pusher syndrome and unilateral spatial neglect.Results:The patient showed typical pusher syndrome and unilateral spatial neglect symptoms. The pusher syndrome and unilateral spatial neglect symptoms were significantly improved following rehabilitation treatments.Conclusions:Pusher syndrome and unilateral spatial neglect syndrome occurred simultaneously after right thalamic hemorrhage. Early rehabilitation therapy can reduce the symptoms of pusher syndrome and unilateral spatial neglect syndrome and improve motor function.
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38

Ishiai, Sumio. "Rehabilitation approaches to unilateral spatial neglect." Higher Brain Function Research 28, no. 3 (2008): 247–56. http://dx.doi.org/10.2496/hbfr.28.247.

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39

Ishiai, Sumio. "Visual world of unilateral spatial neglect." Higher Brain Function Research 30, no. 1 (2010): 1–9. http://dx.doi.org/10.2496/hbfr.30.1.

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40

Halligan, Peter W., Gereon R. Fink, John C. Marshall, and Giuseppe Vallar. "Spatial cognition: evidence from visual neglect." Trends in Cognitive Sciences 7, no. 3 (March 2003): 125–33. http://dx.doi.org/10.1016/s1364-6613(03)00032-9.

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41

Suzuki, Eiji, Wuxiong Chen, and Tohru Kondo. "Measuring unilateral spatial neglect during stepping." Archives of Physical Medicine and Rehabilitation 78, no. 2 (February 1997): 173–78. http://dx.doi.org/10.1016/s0003-9993(97)90260-4.

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42

GILAD, R., M. SADEH, M. BOAZ, and Y. LAMPL. "Visual Spatial Neglect in Multiple Sclerosis." Cortex 42, no. 8 (2006): 1138–42. http://dx.doi.org/10.1016/s0010-9452(08)70226-0.

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43

Chokron, Sylvie, Eve Dupierrix, Matthias Tabert, and Paolo Bartolomeo. "Experimental remission of unilateral spatial neglect." Neuropsychologia 45, no. 14 (January 2007): 3127–48. http://dx.doi.org/10.1016/j.neuropsychologia.2007.08.001.

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44

Yoo, Woo-Kyoung. "Subtypes of Spatial Neglect and Assessment." Brain & Neurorehabilitation 2, no. 1 (2009): 46. http://dx.doi.org/10.12786/bn.2009.2.1.46.

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45

Laurent-Vannier, A., P. Pradat-Diehl, M. Chevignard, G. Abada, and M. De Agostini. "Spatial and motor neglect in children." Neurology 60, no. 2 (January 28, 2003): 202–7. http://dx.doi.org/10.1212/01.wnl.0000048201.26494.0b.

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46

Broadway, Amy. "Eye Patching in Unilateral Spatial Neglect." Neurology Report 23, no. 3 (1999): 129–30. http://dx.doi.org/10.1097/01253086-199923030-00018.

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47

Gainotti, Guido. "The dilemma of unilateral spatial neglect." Neuropsychological Rehabilitation 4, no. 2 (June 1994): 127–32. http://dx.doi.org/10.1080/09602019408402269.

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48

Milner, A. David, and Monika Harvey. "Toward a taxonomy of spatial neglect." Neuropsychological Rehabilitation 4, no. 2 (June 1994): 177–81. http://dx.doi.org/10.1080/09602019408402279.

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49

Beis, J. M., J. M. André, A. Barre, and J. Paysant. "Mirror images and unilateral spatial neglect." Neuropsychologia 39, no. 13 (January 2001): 1444–50. http://dx.doi.org/10.1016/s0028-3932(01)00065-3.

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50

Adair, John C., and Anna M. Barrett. "Spatial Neglect: Clinical and Neuroscience Review." Annals of the New York Academy of Sciences 1142, no. 1 (October 2008): 21–43. http://dx.doi.org/10.1196/annals.1444.008.

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