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Dissertations / Theses on the topic 'Spatial disease'

Author: Grafiati

Published: 11 March 2023

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1

Brockmann, Dirk, Vincent David, and Alejandro Morales Gallardo. "Human mobility and spatial disease dynamics." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-188611.

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The understanding of human mobility and the development of qualitative models as well as quantitative theories for it is of key importance to the research of human infectious disease dynamics on large geographical scales. In our globalized world, mobility and traffic have reached a complexity and volume of unprecedented degree. Long range human mobility is now responsible for the rapid geographical spread of emergent infectious diseases. Multiscale human mobility networks exhibit two prominent features: (1) Networks exhibit a strong heterogeneity, the distribution of weights, traffic fluxes an

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2

Brockmann, Dirk, Vincent David, and Alejandro Morales Gallardo. "Human mobility and spatial disease dynamics." Diffusion fundamentals 11 (2009) 2, S. 1-27, 2009. https://ul.qucosa.de/id/qucosa%3A13918.

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The understanding of human mobility and the development of qualitative models as well as quantitative theories for it is of key importance to the research of human infectious disease dynamics on large geographical scales. In our globalized world, mobility and traffic have reached a complexity and volume of unprecedented degree. Long range human mobility is now responsible for the rapid geographical spread of emergent infectious diseases. Multiscale human mobility networks exhibit two prominent features: (1) Networks exhibit a strong heterogeneity, the distribution of weights, traffic fluxes an

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3

Poliakoff, Ellen. "Parkinson's disease and tactile spatial attention." Thesis, University of Manchester, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488341.

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4

Choo, Louise Lin-Ching. "Investigating spatial variations of disease in epidemiology." Thesis, University of Bath, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438653.

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5

Richardson, Jennifer. "Topics in statistics of spatial-temporal disease modelling." Thesis, Durham University, 2009. http://etheses.dur.ac.uk/2122/.

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This thesis is concerned with providing further statistical development in the area of space-time modelling with particular application to disease data. We briefly consider the non-Bayesian approaches of empirical mode decomposition and generalised linear modelling for analysing space-time data, but our main focus is on the increasingly popular Bayesian hierarchical approach and topics surrounding that. We begin by introducing the hierarchical Poisson regression model of Mugglin et al. [36] and a data set provided by NHS Direct which will be used to illustrate our results through-out the remai

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6

Morris, Emily. "Identifying Spatial Data Needs for Chagas Disease Mitigation." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19312.

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The objective of this thesis is to analyze how existing data can address Chagas disease transmission risk in South America given data availability. A literature review was conducted to determine prominent variables that models use to assist with Chagas disease mitigation efforts, followed by a Web search to collect publicly available spatial data pertaining to these variables. The data were then used to create maps of data availability and in an agent-based model to identify which variables are most associated with disease transmission risk. Data availability varied widely across South Ameri

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7

Wink, Brian. "Spatial coding in human peripheral vision." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296632.

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8

Allepuz, Palau Alberto. "Spatial analysis of Aujeszky's disease eradication in Catalonia, Spain." Doctoral thesis, Universitat Autònoma de Barcelona, 2008. http://hdl.handle.net/10803/5620.

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El programa d'eradicació de la malaltia d'Aujeszky va començar a Espanya l'any 1995, però no va ser fins el 2003, quan a causa de les garanties suplementàries establertes en els intercanvis intracomunitaris de l'espècie porcina amb relació a la malaltia d'Aujeszky, que aquest programa es va reforçar i es varen establir les bases del programa coordinat de lluita, control i eradicació de la malaltia. L'objectiu d'aquest estudi és realitzar una anàlisi espacial de l'eradicació de la malaltia d'Aujeszky a Catalunya (Espanya) des del 2003 fins el 2007. L'estudi s'ha dividit en quatre períodes, en b

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9

Liu, Lili 1962. "Deficits in spatial orientation skills in individuals with Alzheimer's disease." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61658.

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10

Su, Ting-Li. "Application of spatial statistics to space-time disease surveillance data." Thesis, Lancaster University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441128.

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11

Bessell, Paul R. "Spatial epidemiology of Foot and Mouth Disease in Great Britain." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4831.

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During 2007 the UK experienced outbreaks of three notifiable exotic livestock diseases; Foot and Mouth Disease (FMD), Highly Pathogenic Avian Influenza (HPAI) and bluetongue. Large epidemics of any of these diseases would have a serious impact on animal welfare, farming, food production and the economy. In light of this, understanding holdings which are most likely to acquire and spread infection and being able to identify areas at higher risk of an epidemic is valuable when preparing for and managing an epidemic. This thesis uses a spatial epidemiological framework and the detailed disease an

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12

Newton, Rosemary. "Spatial and temporal patterns of witches' broom disease on proteas." Thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/26008.

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13

Liu, Lili 1962. "Assessment of spatial orientation in Alzheimer's disease : theoretical and clinical implications." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41176.

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The purpose of this project was to develop a reliable and valid battery for the assessment of spatial orientation skills (SOS) in persons with Alzheimer's disease (AD). The battery, comprised of 13 subtests, was administered to 97 normal control subjects, 25 subjects with early AD and 10 with late AD. The test-retest reliability of the battery was based on the test results of 33 normal control subjects and 25 early AD subjects. Inter-rater reliability was determined using four trained raters who evaluated 27 normal control subjects and the same 25 early AD subjects. Content validity was establ

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14

Luo, Weiqi. "Spatial/temporal modelling of crop disease data using high-dimensional regression." Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493292.

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Septoria tritici is one of the most serious foliar diseases of winter wheat across England and Wales, causing considerable reduction in yield quality and production. There are increasing pressures to control such a disease using disease forecasting systems sociated with various meteorological factors.

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15

Lindström, Tom. "Spatial Spread of Organisms : Modeling ecological and epidemiological processes." Doctoral thesis, Linköpings universitet, Teoretisk Biologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54839.

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This thesis focuses on the spread of organisms in both ecological and epidemiological contexts. In most of the studies presented, displacement is modeled with a spatial kernel function, which is characterized by scale and shape. These are measured by the net squared displacement (or kernel variance) and kurtosis, respectively. If organisms disperse by the assumptions of a random walk or correlated random walk, a Gaussian shaped kernel is expected. Empirical studies often report deviations from this, and commonly leptokurtic distributions are found, often as a result of heterogeneity in the dis

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16

Clement, Bridget Williams. "Object and spatial recognition in the ischemic gerbil." Thesis, Montana State University, 2010. http://etd.lib.montana.edu/etd/2010/clement/ClementB0510.pdf.

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The Mongolian gerbil is extensively used to model transient cerebral ischemia, a type of stroke that can occur with anoxia and cardiac arrest. A global ischemic insult in the gerbil produces damage to hippocampal CA1 pyramidal cells comparable to that observed in humans. A limited number of models are available to evaluate the behavioral consequences of cerebral ischemia in the gerbil. The goal of the present experiments was to evaluate the impact of transient cerebral ischemia on object and spatial recognition memory as these tasks have not been previously utilized with the gerbil model. Foll

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17

Gahl, Megan K. "Spatial and Temporal Patterns of Amphibian Disease in Acadia National Park Wetlands." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/GahlMK2007.pdf.

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18

Conlon, Erin Marie. "Estimation and flexible correlation structures in spatial hierarchical models of disease mapping /." Diss., ON-CAMPUS Access For University of Minnesota, Twin Cities Click on "Connect to Digital Dissertations", 1999. http://www.lib.umn.edu/articles/proquest.phtml.

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19

Ribeiro, Ana Isabel Correia. "Morbidity and mortality of coronary heart disease: a study of spatial epidemiology." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/55362.

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20

Li, Xuan. "Planning for Spatial Analysis of Links between Parkinson Disease and Pesticide Exposure." University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1310051225.

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21

Lin, Shu-Chuan. "Robust estimation for spatial models and the skill test for disease diagnosis." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/26681.

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Thesis (Ph.D)--Industrial and Systems Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Lu, Jye-Chyi; Committee Co-Chair: Kvam, Paul; Committee Member: Mei, Yajun; Committee Member: Serban, Nicoleta; Committee Member: Vidakovic, Brani. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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22

Ribeiro, Ana Isabel Correia. "Morbidity and mortality of coronary heart disease: a study of spatial epidemiology." Dissertação, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/55362.

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23

Naish, Suchithra. "Spatial and temporal analysis of Barmah Forest virus disease in Queensland, Australia." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/55047/1/Suchithra_Naish_Thesis.pdf.

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Barmah Forest virus (BFV) disease is one of the most widespread mosquito-borne diseases in Australia. The number of outbreaks and the incidence rate of BFV in Australia have attracted growing concerns about the spatio-temporal complexity and underlying risk factors of BFV disease. A large number of notifications has been recorded continuously in Queensland since 1992. Yet, little is known about the spatial and temporal characteristics of the disease. I aim to use notification data to better understand the effects of climatic, demographic, socio-economic and ecological risk factors on the spati

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24

Lineweaver, Tara T. "An investigation of visuospatial orientation and mental rotation in patients with Alzheimer's disease and patients with Huntington's disease /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9935484.

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25

Baker, Jannah F. "Bayesian spatiotemporal modelling of chronic disease outcomes." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/104455/1/Jannah_Baker_Thesis.pdf.

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This thesis contributes to Bayesian spatial and spatiotemporal methodology by investigating techniques for spatial imputation and joint disease modelling, and identifies high-risk individual profiles and geographic areas for type II diabetes mellitus (DMII) outcomes. DMII and related chronic conditions including hypertension, coronary arterial disease, congestive heart failure and chronic obstructive pulmonary disease are examples of ambulatory care sensitive conditions for which hospitalisation for complications is potentially avoidable with quality primary care. Bayesian spatial and spatiote

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26

More, Alan. "The invisible asthmatic : developing geographies of asthma in England." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246229.

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27

Read, Jessica Sian. "Development of methodology for identifying spatial links between environmental exposure and disease prevalence." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54602/.

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The recent increased availability of geographically linked individual level health outcome data and improvements in exposure mapping techniques, which furnish point exposure estimates, motivate the development of spatial statistical methodology that takes full advantage of individual level data. Kernel density estimation is a powerful tool for mapping the risk of a health outcome that uses individual level data. Development of kernel density methodology has provided a global significance test for regions of elevated relative risk and a test for the spatial association between a health outcome

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28

Ferri, Christopher A. "The effect of angiotensin receptor blocker inhibition on spatial memory and Alzheimer's disease." Thesis, Boston University, 2009. https://hdl.handle.net/2144/28567.

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Boston University. University Professors Program Senior theses.<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>2031-01-02

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29

Jahan, Farzana. "New insights into Bayesian models for spatial data." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212622/1/Farzana%20Jahan%20Thesis.pdf.

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Spatial data is often aggregated into small area. It is challenging to analyse these data. Two new statistical techniques were developed to tackle these challenges. Bayesian meta-analysis models were used to unveil geographic disparities in cancer using the Australian Cancer Atlas. More flexible Bayesian Empirical Likelihood models were used to analyse more complex data including COVID19 deaths. Both methods provided new insights into the analysis of spatial data.

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30

RONCHI, ROBERTA. "Behavioural monitoring disorders in unilateral spatial neglect: productive symptoms and impaired awareness of disease." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19801.

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This doctoral thesis investigates the relationships between disorders of behavioural monitoring (including “productive” behaviours and unawareness of neuropsychological deficits) and unilateral spatial neglect in right-brain-damaged patients. One main monitoring disorder is recurrent perseveration, namely a “productive” motor symptom frequently found in target cancellation tasks: we demonstrate, in two specific tasks (Experiments 1 and 2), that the disposition of the stimuli and the type of target modulate its severity. Neglect patients showing perseveration in visuo-motor exploratory tests p

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31

Dymond, Sara Elizabeth. "Lyme Disease Emergence in Virginia: An Examination of the Demographic and Environmental Variables Correlated to the Spatial Pattern of Disease Incidence." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/50942.

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Since its initial identification in 1975, Lyme disease has become a public health concern in the U.S. Increased concern is sparked by the rapid rate at which the disease is emerging into new areas. One area of disease emergence is the state of Virginia which has been experiencing exponentially increasing rates of the disease. This research studies Virginia\'s landscape-level habitats to explore demographic and environmental variables related to the spread of Lyme disease. <br /><br />The land cover data came from the National Land Cover Database (2006), demographic data came from the U.S. c

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32

Lamouroux, David. "Cyclic Dynamics of Spatially Heterogeneous Populations - From Biodiversity to Disease Prevalence." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F289-9.

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33

Bauch, Christopher Thomas. "Moment closure approximations in epidemiology." Thesis, University of Warwick, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364626.

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34

Hansell, Anna L. "The epidemiology of chronic obstructive pulmonary disease in the UK : spatial and temporal variations." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/12038.

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35

Gonzalez, Marjorie Emily. "Spatial analysis of positron emission tomography images of Parkinson's disease using 3D moment invariants." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43137.

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Positron emission tomography (PET) produces images of functional processes of the body in-vivo. The analysis of PET data for research purposes traditionally involves kinetic modeling of the concentration of the radiotracer over time within a region of interest (ROI) in the body to derive parameters related to the uptake/binding of the radiotracer in that region. PET imaging is commonly used to study Parkinson's disease (PD), where loss of motor function is caused by the progressive death of neurons in the brain that produce the neurotransmitter dopamine. In PD, both the kinetic and the spatial

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36

Charest, Jollin. "Spatial distribution and dose-disease relationship of airborne ascospores of Venturia inaequalis on apple." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30812.

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Apple scab is the most important disease of apples in most of the world. The disease, caused by Venturia inaequalis, is controlled by numerous fungicide applications, regardless of the presence of inoculum in the orchard. Better timing of fungicide applications could be achieved if the airborne ascospore concentration (AAC) was considered in decision making. AAC can be measured in real time using spore traps. In this project, the relationship between AAC and lesions development was studied under controlled and natural conditions for five cultivars: Empire, McIntosh, Jonagold, Royal Gala, and S

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37

Bonnell, Tyler. "Spatial simulations of infectious disease: environment, behaviour, and their interaction in a primate population." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=122993.

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Recent trends in emerging and re-emerging human infectious disease indicate that zoonotic diseases are on the rise (e.g., SARS, Swine Flu, Bird flu, Ebola, and Lyme disease), creating large economic and social costs. The increasingly dominant role that humans are playing in changing the environment is thought to be a leading cause for this increasing emergence. In this dissertation, I investigated the effects of landscape level changes on a specific host parasite system: red colobus (Procolobus rufomitratus) and gastrointestinal nematode parasites within Kibale National Park, Uganda landscape.

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38

Smallman-Raynor, Matthew R. "Geographical aspects of AIDS : pattern, process and spatial scale in HIV infection and disease." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239202.

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39

Markostamou, Ioanna. "Spatial language abilities and cognition across the adult-lifespan and in early Alzheimer's disease." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/66956/.

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Space constitutes one of the core framing structures of experience in the natural environment. Therefore, communicating spatial information with verbal means, such as locative relations between objects, is vital for numerous everyday activities and constitutes a core part of human linguistic communication. The present project aimed to 1) develop psychometrically sound measures assessing spatial language abilities, including naming static and dynamic spatial relations, memory for route- and survey-based descriptions, and comprehension of descriptions of locative relations under different spatia

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40

Deribe, Kebede. "Mapping the spatial distribution and epidemiology of podoconiosis in Ethiopia : implications for disease control." Thesis, University of Brighton, 2016. https://research.brighton.ac.uk/en/studentTheses/c3bd5446-7507-4da6-85e7-427778bf59fd.

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In the last ten years, there has been significant progress towards the prevention, control and elimination of podoconiosis as a health problem. There are however gaps in our understanding of the epidemiology and geography of podoconiosis that hinder the planning and scale-up of intervention activities. Therefore, this PhD project aimed to define the current geographical distribution and disease burden of podoconiosis in Ethiopia and investigate underlying risk factors. This thesis adopted two main approaches to understanding distribution: first, historical data were compiled and analysed; seco

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41

Blackley, David, Shimin Zheng, and Winn Ketchum. "Implementing a Weighted Spatial Smoothing Algorithm to Identify a Lung Cancer Belt in the United States." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/42.

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Lung cancer is the leading cause of cancer death in the United States, but a large fraction of cases is preventable. We use a spatial smoothing algorithm to identify a geographic pattern of high lung cancer mortality, primarily in the Southeast, which we call a lung cancer belt. Disease belts are an effective mode for conveying patterns of high incidence or mortality; formally defining this lung cancer belt may encourage increased public dialogue and more focused research. Public health officials could complement existing population lung cancer data with this information to help inform resourc

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42

Pearce, Brielle H. "Three surveillance systems for describing the spatial distribution of Johne's disease seropositivity in Texas cattle." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2510.

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43

Ruckthongsook, Warangkana. "The Influence of Disease Mapping Methods on Spatial Patterns and Neighborhood Characteristics for Health Risk." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1062838/.

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This thesis addresses three interrelated challenges of disease mapping and contributes a new approach for improving visualization of disease burdens to enhance disease surveillance systems. First, it determines an appropriate threshold choice (smoothing parameter) for the adaptive kernel density estimation (KDE) in disease mapping. The results show that the appropriate threshold value depends on the characteristics of data, and bandwidth selector algorithms can be used to guide such decisions about mapping parameters. Similar approaches are recommended for map-makers who are faced with decisio

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44

Kerai, Julie Hiralal. "The role of pre-supplementary motor area in spatial vector transformation : evidence from Parkinson's disease." Thesis, Bangor University, 2013. https://research.bangor.ac.uk/portal/en/theses/the-role-of-presupplementary-motor-area-in-spatial-vector-transformation-evidence-from-parkinsons-disease(9abd8a26-a331-417f-9a0a-0ee14e69ce2b).html.

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This thesis investigated the role of the supplementary motor area (SMA) in visuospatial processing using Parkinson’s disease (PD) patients as a model of pre-supplementary motor area (pre-SMA) dysfunction. The vector transformation hypothesis assumes that visuospatial transformation deficits in PD are a result of impairments in calculating vectors or co-ordinate remapping with a reference frame. These vector transformation processes were investigated in spatial normalisation during mental rotation and showed that PD patients demonstrate slower image normalisation rates indicative of a deficit c

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45

Wanelik, Klara. "Interactions between avian colonial social structure and disease dynamics." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:10f5a660-100c-4f59-a7d6-c34335d085a9.

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All wildlife populations harbour parasites. However, seabirds are likely to play a particularly important role in the maintenance and dispersal of infectious agents as a result of their colonial breeding habits. Seabird colonies are also known to be highly spatially structured, but little is known about the effects of this spatial structuring on seabird parasite dynamics. In this thesis, I use a tick-borne virus, Great Island virus (GIV), found in a large common guillemot (Uria aalge) colony bordering the North Sea as a model system to explore this relationship. I use a multidisciplinary appro

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46

Le, Viet Thanh. "Dengue spatial dynamics : the example of Northern Vietnam." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT053/document.

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Alors que l’épidémiologie de la dengue dans le sud du Vietnam est caractérisée par un régime d’hyper-endémicité, la maladie est en train d’émerger dans le nord du pays depuis une quinzaine d’années. Les incidences annuelles augmentent de façon constante d’année en année et la maladie diffuse à partir de Hanoi vers les zones rurales environnantes. Le travail de recherche effectué durant cette thèse s’intéresse aux déterminants spatiaux et temporels de la transmission de la dengue dans un contexte d’émergence. Les résultats sont organisés en 3 parties. La première se concentre sur l’étude d’une

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47

Cramb, Susanna M. "Spatio-temporal modelling of cancer data in Queensland using Bayesian methods." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/89739/1/Susanna_Cramb_Thesis.pdf.

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Cancer is the leading contributor to the disease burden in Australia. This thesis develops and applies Bayesian hierarchical models to facilitate an investigation of the spatial and temporal associations for cancer diagnosis and survival among Queenslanders. The key objectives are to document and quantify the importance of spatial inequalities, explore factors influencing these inequalities, and investigate how spatial inequalities change over time. Existing Bayesian hierarchical models are refined, new models and methods developed, and tangible benefits obtained for cancer patients in Queensl

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48

Lecumberri, Sanchez Pilar. "Spatial and temporal evolution of fluids in hydrothermal ore deposits." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50960.

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Magmatic-hydrothermal systems typically have vertical extents of several hundred<br />meters and their geochemical characteristics (e.g. mineral assemblages) vary considerably<br />over that vertical extent. As a consequence the expression in outcrop varies depending on<br />the level of erosion. Therefore understanding the geochemical zonation of magmatic-hydrothermal<br />ore deposits opens the possibility to detect deep magmatic-hydrothermal<br />systems, and to assess qualitatively the degree of erosion that has taken place in the area<br />and at which level the mineralization may occur.

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49

Cespedes, Marcela I. "Detection of longitudinal brain atrophy patterns consistent with progression towards Alzheimer's disease." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/118289/1/Marcela_Cespedes_Thesis.pdf.

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This thesis develops and applies statistical methodologies to model brain atrophy in humans among multiple brain regions and how this may change over time. Throughout this work, Bayesian multilevel models are progressively developed for single and multiple regions at a given time point as well as modelling how connectivity between multiple regions evolves over time in conjunction with region level estimates. The application of these models provide insight into the detection of longitudinal brain atrophy patterns consistent with healthy ageing or progression towards Alzheimer's disease, and sho

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Hockham, Carinna. "Exploring the spatial epidemiology and population genetics of malaria-protective haemoglobinopathies." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:9ce0e255-a0b3-44af-af16-f0e6341c40ed.

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Haemoglobinopathies, which include sickle-cell anaemia (SCA) and α- and β-thalassaemia, represent some of our few unequivocal examples of human evolution. The underlying genetic mutations reflect a recurring adaptation against one of the biggest infectious disease killers of humans, Plasmodium falciparum malaria. Inheritance of one copy of a sickle-cell or thalassaemic allele leads to protection against death from malaria, while two copies can result in a severe blood disorder. As a result, haemoglobinopathies have risen in frequency through balancing selection and pose a significant public he

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