Academic literature on the topic 'Space sciences not elsewhere classified'
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Journal articles on the topic "Space sciences not elsewhere classified"
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Bannister, Frank, and Dan Remenyi. "Acts of Faith: Instinct, Value and it Investment Decisions." Journal of Information Technology 15, no. 3 (September 2000): 231–41. http://dx.doi.org/10.1177/026839620001500305.
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Although well over 1000 journal articles, conference papers, books, technical notes and theses have been written on the subject of information technology (IT) evaluation, only a relatively small subset of this literature has been concerned with the core issues of what precisely is meant by the term ‘value’ and with the process of making (specifically) IT investment decisions. All too often, the problem and highly complex issue of value is either simplified, ignored or assumed away. Instead the focus of much of the research to date has been on evaluation methodologies and, within this literature, there are different strands of thought which can be classified as partisan, composite and meta approaches to evaluation. Research shows that a small number of partisan techniques are used by most decision makers with a minority using a single technique and a majority using a mixture of such techniques of whom a substantial minority use a formal composite approach. It is argued that, in mapping the set of evaluation methodologies on to what is termed the investment opportunity space, that there is a limit to what can be achieved by formal rational evaluation methods. This limit becomes evident when decision makers fall back on ‘gut feel’ and other non-formal/rigorous ways of making decisions. It is suggested that an understanding of these more complex processes and decision making, in IT as elsewhere, needs tools drawn from philosophy and psychology.
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Skinner, G. William, Mark Henderson, and Yuan Jianhua. "China’s Fertility Transition through Regional Space." Social Science History 24, no. 3 (2000): 613–52. http://dx.doi.org/10.1017/s0145553200010312.
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Key features of reproductive behavior in China vary systematically through space and time. In this article we present an analysis of fertility change in regional space, using a 1% household sample from China’s 1990 population census. Elsewhere,we use the same data to analyze reproductive strategizing, but here we pursue the big picture with a straightforward analysis that takes reported births as an uncomplicated indicator of fertility.The article has three objectives: first, to introduce a novel, multilevel spatial model of regional structure constructed using a geographic information system (GIS); second, to demonstrate the potential for longitudinal data derived from onetime censuses to contribute to historical demography in conjunction with regional analysis; and third, to document the manner in which China’s fertility transition has unfolded in regional space.
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WALTON, JOHN K., and DAVID TIDSWELL. "‘Classified at random by veritable illiterates’: the taking of the Spanish census of 1920 in Guipúzcoa province." Continuity and Change 20, no. 2 (August 2005): 287–313. http://dx.doi.org/10.1017/s0268416005005503.
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This article offers an approach through administrative and cultural history to the problems associated with gathering and processing data for the Spanish national census of 1920, and by implication for earlier Spanish censuses. It focuses on the Basque province of Guipúzcoa, making use of correspondence between the central statistical office in Madrid, the provincial jefe de estadística and the localities, and of reports on three problematic towns within the province. The issues that emerge regarding ‘undercounting’, the definition of administrative boundaries and the classification of demographic characteristics are set in the wider context of census-taking practices and problems elsewhere in Spain and in other cultures.
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Montmerle, Thierry, Philippe Claeys, Muriel Gargaud, Purificatión López-García, Hervé Martin, Robert Pascal, Jacques Reisse, and Franck Selsis. "9. Life On Earth... And Elsewhere?" Earth, Moon, and Planets 98, no. 1-4 (October 4, 2006): 299–312. http://dx.doi.org/10.1007/s11038-006-9093-7.
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Zewail, Ahmed H. "Diffraction, crystallography and microscopy beyond three dimensions: structural dynamics in space and time." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 363, no. 1827 (December 6, 2004): 315–29. http://dx.doi.org/10.1098/rsta.2004.1513.
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In this article we highlight recent developments of ultrafast electron diffraction and crystallography at Caltech. These developments have made it possible to resolve transient structures, both spatially (0.01 Å) and temporally (picosecond and now femtosecond), in the gas phase and condensed media—surfaces, interfaces, and crystals—with wide-ranging applications. With the extension to ultrafast electron microscopy, discussed here and elsewhere, we present an overview of one major research area at our centre, the Laboratory for Molecular Sciences.
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Pukk, Mari. "Printed-pattern headscarves in Kihnu cultural space." Studia Vernacula 11 (November 5, 2019): 78–101. http://dx.doi.org/10.12697/sv.2019.11.78-101.
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This article provides an overview of the unique tradition of wearing headscarves as practiced by the islanders of Kihnu. I discuss the importance of cotton print headscarves in the traditional clothing of Kihnu women and explain the meaning of kallisseltsi headscarves as an intra-community phenomenon, giving an overview of the origin and characteristics thereof.
Printed cotton headscarves are considered an integral part of Kihnu traditional clothing, but as purchased goods they have, up to the present, remained beyond the scope of ethnographic studies. Headscarves are classified by material, origin and purpose. Even today, seven different types of headscarves are known ; names were assigned to the different types based on their patterns.
Headscarves must always be worn in harmony with the main item of clothing: the skirt. The colours and stripes of the skirt convey the events that take place in the course of a woman’s life. Adherence to the rules is supervised by the elders of the community and by the more knowledgeable members who look after the preservation of the island’s traditions. As with wearing, there are also specific unwritten rules concerning the care, storage and folding of headscarves.
In the Kihnu community, the most valuable cotton headscarves are those made of red printed cotton fabric that were produced in Russia, in the factories of Aleksandrov County in the Province of Vladimir in the late 19th century and the early 20th century. Elsewhere in the world, the headscarves are also known by their main colour – Turkish red. Owning kallisseltsi headscarves is, in a way, a status symbol in the Kihnu community: the owner of the largest number of headscarves is considered the proudest and richest. The circulation of headscarves is very carefully monitored, and the most valuable ones are only worn during important life events.
Keywords: Kihnu cultural space, folk costumes, headscarves, communal clothing norms
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Pukk, Mari. "Printed-pattern headscarves in Kihnu cultural space." Studia Vernacula 11 (November 5, 2019): 78–101. http://dx.doi.org/10.12697/sv.2019.11.78-101.
Full textAbstract:
This article provides an overview of the unique tradition of wearing headscarves as practiced by the islanders of Kihnu. I discuss the importance of cotton print headscarves in the traditional clothing of Kihnu women and explain the meaning of kallisseltsi headscarves as an intra-community phenomenon, giving an overview of the origin and characteristics thereof.
Printed cotton headscarves are considered an integral part of Kihnu traditional clothing, but as purchased goods they have, up to the present, remained beyond the scope of ethnographic studies. Headscarves are classified by material, origin and purpose. Even today, seven different types of headscarves are known ; names were assigned to the different types based on their patterns.
Headscarves must always be worn in harmony with the main item of clothing: the skirt. The colours and stripes of the skirt convey the events that take place in the course of a woman’s life. Adherence to the rules is supervised by the elders of the community and by the more knowledgeable members who look after the preservation of the island’s traditions. As with wearing, there are also specific unwritten rules concerning the care, storage and folding of headscarves.
In the Kihnu community, the most valuable cotton headscarves are those made of red printed cotton fabric that were produced in Russia, in the factories of Aleksandrov County in the Province of Vladimir in the late 19th century and the early 20th century. Elsewhere in the world, the headscarves are also known by their main colour – Turkish red. Owning kallisseltsi headscarves is, in a way, a status symbol in the Kihnu community: the owner of the largest number of headscarves is considered the proudest and richest. The circulation of headscarves is very carefully monitored, and the most valuable ones are only worn during important life events.
Keywords: Kihnu cultural space, folk costumes, headscarves, communal clothing norms
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Read, Peter L., and Sebastien Lebonnois. "Superrotation on Venus, on Titan, and Elsewhere." Annual Review of Earth and Planetary Sciences 46, no. 1 (May 30, 2018): 175–202. http://dx.doi.org/10.1146/annurev-earth-082517-010137.
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The superrotation of the atmospheres of Venus and Titan has puzzled dynamicists for many years and seems to put these planets in a very different dynamical regime from most other planets. In this review, we consider how to define superrotation objectively and explore the constraints that determine its occurrence. Atmospheric superrotation also occurs elsewhere in the Solar System and beyond, and we compare Venus and Titan with Earth and other planets for which wind estimates are available. The extreme superrotation on Venus and Titan poses some difficult challenges for numerical models of atmospheric circulation, much more difficult than for more rapidly rotating planets such as Earth or Mars. We consider mechanisms for generating and maintaining a superrotating state, all of which involve a global meridional overturning circulation. The role of nonaxisymmetric eddies is crucial, however, but the detailed mechanisms may differ between Venus, Titan, and other planets.
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Shostak, Moderator: Seth, Participants: Ben Zuckerman, Mitsumi Fujishita, Paul Horowitz, and Dan Werthimer. "Are We Any Closer to Finding Intelligent Life Elsewhere?" Astrobiology 11, no. 6 (July 2011): 487–92. http://dx.doi.org/10.1089/ast.2011.1701.
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Matthews, Graham, and Graham Walton. "Strategic development of university library space." New Library World 115, no. 5/6 (May 6, 2014): 237–49. http://dx.doi.org/10.1108/nlw-05-2014-0062.
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Purpose – The purpose of this paper is to explore issues, approaches and challenges in providing strategic direction to university libraries on developing their physical space in what is increasingly a digital age. A key aspect of the work is to explore how university libraries and their senior staff can widen libraries’ role to inform the strategic direction of formal and informal learning spaces across the institution. Design/methodology/approach – Research and perspectives from across the world provide the context for the study. A single site case study based at Loughborough University in the UK is explored to demonstrate how strategy for university library space is developed. The case study also provides an example of how a university library has extended its influence on other informal learning spaces. Findings – University library physical space has an important role in learning, teaching and research, despite the increase in digital information provision. For effective strategy, information and evidence needs to be collected from a wide range of sources. The experience and skills that university libraries have developed in managing learning spaces can be transferred to learning spaces elsewhere in the university. Research limitations/implications – This is a single site case study. Practical implications – The case study provides approaches and ideas that can be applied by university libraries in the strategic development of learning spaces. Originality/value – The paper provides an innovative and informed insight into how university libraries can influence learning and teaching spaces across university campus/site. Further research would be valuable to identify practice more widely. Surveying, from a library perspective, university and university estate, management strategies for content relating to libraries and formal and informal spaces across the institution and what is going on/being planned in this area would further progress the debate.
Dissertations / Theses on the topic "Space sciences not elsewhere classified"
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Armstrong, Keith M. "Towards an Ecosophical Praxis of New Media Space design." Thesis, QUT, 2003. https://eprints.qut.edu.au/9073/1/PHDTHESISKMAsmall.pdf.
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This study is an investigation in and through media arts practice. It set out to
develop a novel type of new media artistic praxis built upon concepts drawn from
the disciplines of scientific and cultural ecology. The rationale for this research was
based upon my observation as a practising new media artist that existing praxis in
the new media domain appeared to operate largely without awareness of the
ecological implications of those practices.
The thesis begins by explaining key concepts of ecology, spanning the arts and the
sciences. It then outlines the thinking of contemporary theorists who propose that
the problem of ecology is a critical issue for the 21st century, suggesting that our
well-documented ecological crisis is indicative of a more general crisis of human
subjectivity. It then records an investigation into particular strategies for artistic
praxis which might instigate an active engagement with this problem of ecology.
The study employed a methodology based in action research to focus upon the
development and analysis of three new artistic works, '#14', 'Public Relations' and
'transit_lounge'. These were used to explore diverse theories of ecology and to
hone a series of pointers towards Ecosophical arts/new media praxis. This journey
constitutes an emergent theory for new media space design.
The thesis concludes with a toolkit of tactics and approaches that other arts/new
media practitioners might employ to begin working on the problem of ecology.
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Oechsler, Monika. "Interstitial space : the Eagle Document : performativity and spatio-temporal assemblage in the contemporary moving image installation space (MIS)." Thesis, University of Brighton, 2011. https://research.brighton.ac.uk/en/studentTheses/08db6f60-822e-4ed3-96ac-577b307369d7.
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This study investigates the perceptive modalities constituted by the multi-screen projection installation and its architectural and spatial forms. The thesis explores the hypothesis that the affective spatial experience created by the spatially configured moving image space (MIS) produces changed spectatorial positions from that of the single screen (or one-directional multi screen). The research asks: How can we understand the spatially configured multi-screen projection installation as constituting a changed aesthetic perception for the spectator? The MIS comprises two major temporalities, the multi-image structure and the mobile spectator whose physical interaction articulates the receptive process. Thus, perception in the MIS is not purely constructed through vision. Instead, the spatio-temporal assemblage shapes other direct sense phenomena. These are the spatial intensities produced by the spatial field, i.e. variable sensations of spatial receptivity, which are not mediated by the gaze but experienced directly by the body. Further, the mobile gaze of the moving spectator intersects with the moving images, and constructs vision as fluid and transient. Merleau-Ponty (2006), first published 1945, proposed that the mobile orientation of the body in space creates changing points of reference and alters both vision and embodied experience of space. The analysis of two inter-related concepts aims to contribute to a new understanding of the MIS. The first is the interstitial modality established by the screen architecture which engenders temporal and spatial gaps that interrupt the process of perception. Interstitiality here serves as an analytical tool in discerning the specific spectatorial positions instituted by individual installations. The second is the process of inter-animation which is constituted by the corporeal interaction of the spectator in the animated space of the MIS. Spatial and temporal effects act upon the body of the viewer. In turn, the viewer negotiates the unfamiliar space and multiple interstices through intuitive reaction. Deleuze (1994), first published 1968, suggested that spatial intensities and differences create immediate sensory impact which is experienced as intuition. Intuition intervenes in the visual process and expands perception from observation and reflection to intuitive action.
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Han, Eunju. "Locative interaction in urban space : programmatic flexibility." Thesis, Royal College of Art, 2012. http://researchonline.rca.ac.uk/1360/.
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Human spatial experience has recently expanded due to the development of location-aware technology. Locative information has become more significant within urban space; as such, related discourses have attempted to focus on the issue as a way in which we acquire locative information when we experience space. Digital location-aware methods enable the demonstration of live densities of telecommunication through which one can infer temporal and spatial factors of live urban situations. When locative telecommunication data is mapped onto urban space, temporal-spatial demographic maps are obtained. Based on these maps, one can infer the correlation between spatial experience and architectural programmes via on site observation and by determining the multi-layered structure of spatial experience via designed data installation. These considerations aim to investigate locative interaction in urban space in order to expand spatial experience. This research begins with two linked theoretical notions: rhythm analysis and heterotopia—in other words, temporality as it relates to our everyday life and spatiality as it relates to our search for ideal space. In addition to these positions, the following discourses are specifically developed to investigate locative interaction in urban space. Firstly, the temporal and spatial patterns of urban activities are investigated in an attempt to grasp current urban interactions. The telecommunication data is then mapped geographically. Secondly, the gap between the endowed architectural programmes and the observed activities in urban space is explored in order to examine the multi-layered structure of urban interaction. Thirdly, the above discussions are synthesised using a design project that interprets epistemic aspects of this initiative. Lastly, urban rhythms and locative virtual layers are suggested as the concept for locative interaction in urban space where architectural programmes become more flexible, thus expanding spatial experience. Two projects demonstrate as applicable scenarios of locative interaction in urban space; they involve a heterotopia finder and a floating gallery over London. This research suggests a new viewpoint from which to consider our world and its digital presence by mapping a ‘live urban space’ using telecommunication data—an initiative that highlights the importance of people as a crucial aspect of our digital surroundings. This research ultimately contributes to expanding urban spatial experience and providing an informative and holistic mapping structure for architecture and urban design, interweaving it with the digital environment.
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Stockburger, Axel. "The rendered arena : modalities of space in video and computer games." Thesis, University of the Arts London, 2006. http://ualresearchonline.arts.ac.uk/6507/.
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During the last 30 years computer and videogames have grown into a large entertainment industry of economic as well as cultural and social importance. As a distinctive field of academic inquiry begins to evolve in the form of Game Studies, the majority of approaches can be identified as emerging either from a background of literary theory which motivates a concentration on narrative structures or from a dedicated focus on the rules of video and computer games. However, one of the most evident properties of those games is their shared participation in a variety of spatial illusions. Although most researchers share the view that issues related to mediated space are among the most significant factors characterising the new medium, as of yet, no coherent conceptual exploration of space and spatial representation in video and computer games has been undertaken. This thesis focuses on the novel spatial paradigms emerging from computer and video games. It aims to develop an original theoretical framework that takes the hybrid nature of the medium into account. The goal of this work is to extend the present range of methodologies directed towards the analysis of digital games. In order to reveal the roots of the spatial apparatus at work an overview of the most significant conceptions of space in western thought is given. Henri Lefebvre's reading of space as a triad of perceived, conceived and lived space is adopted. This serves to account for the multifaceted nature of the subject, enables the integration of divergent spatial conceptions as part of a coherent framework, and highlights the importance of experiential notions of spatiality. Starting from Michel Foucault's notion of the heterotopia, game-space is posited as the dynamic interplay between different spatial modalities. As constitutive elements of the dynamic spatial system mobilized by digital games the following modalities are advanced: the physical space of the player, the space emerging from the narrative, the rules, the audiovisual representation and the kinaesthetic link between player and game. These different modalities are examined in detail in the light of a selected range of exemplary games. Based on a discussion of film theory in this context an original model that serves to distinguish between different visual representational strategies is presented. A chapter is dedicated to the analysis of the crucial and often overlooked role of sound for the generation of spatial illusions. It is argued that sound has to be regarded as the privileged element that enables the active use of representational space in three dimensions. Finally the proposed model is mobilised to explore how the work of contemporary artists relates to the spatial paradigms set forth by digital games. The critical dimension of artistic work in this context is outlined. The thesis concludes with a discussion of the impact of the prevalent modes of spatial practice in computer and video games on wider areas of everyday life.
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Faki, Hajira. "The development and evaluation of photo-antimicrobial isoalloxazine dyes towards infection control." Thesis, University of Central Lancashire, 2018. http://clok.uclan.ac.uk/23986/.
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In today’s world, antimicrobial resistance is one of the biggest global health issues that mankind is facing. This most effective way to ensure a wound does not become infected is through cleanliness and continued disinfection of the wound site. There is a lack of new antimicrobial drugs coming to the market due to economical and clinical reasons, this is evident in Lord O’Neill’s 2016 report and is addressed by Professor Dame Sally Davies in Parliament, (“We have reached a critical point and must act now on a global scale to slow down antimicrobial resistance”2). Prescription drugs have led to this epidemic that was highlighted by O’Neill. The latest report (2016) by O’Neill states, it is critical to improve sanitation and hygiene, refrain from overusing antibiotics in agriculture and the environment as well as introducing rapid diagnostics and vaccines3. This is leading to the need for photodynamic antimicrobial chemotherapy (PACT) that involves the use of a reactive oxygen species (ROS), photosensitiser, and light to cause microbial death. PACT is a treatment for resistant and non-resistant pathogens that is included in the treatment of multidrug resistant infections. The approach is to use novel antimicrobial drugs topically, avoiding systemic photo-toxicity, thus leading itself towards topical infection control. Herein, we report the development of a range of novel photosensitisers based on the second generation photodynamic therapeutic dyes (PDT) that are based on the tricyclic isoalloxazine structure of riboflavin, vitamin B2. Photosensitisers were synthesised using similar strategies to the isoalloxazine for a number of reasons: e.g. photoactivity and capability of degradation. In order to investigate which photosensitisers gave the highest reactive oxygen yield, functional group changes were made on the N-phenyl ring by substituting a range of electron withdrawing/donating substituents at different positions (ortho, meta, para). The free amide moiety was used to attach the photosensitiser to a solid support that would act as proof of principal of a photosensitiser attached to a bandage. These dyes show a phototherapeutic response via a Type I and II mechanism upon illumination by light of a selected wavelength. The mechanisms produce highly toxic oxygen-species, such as radical production via Type I pathway and singlet oxygen generation by Type II, thus causing terminal damage to microbes in a short time period. The synthesised photosensitisers are illuminated using blue light (440 - 490 nm) and white light in order to monitor and compare the singlet oxygen and radical yields generated as they absorb approximately at 440 nm, thus blue light being ideal for irradiation. The outstanding singlet oxygen result generated by compound 12c of 172% and a radical production by 11c of 227% show promising generators of cytotoxic species, resulting in microbial death. The synthesised photosensitisers have been tested against two opportunistic microbes (Gram positive and Gram negative bacteria; Staphylococcus aureus (S. aureus), and Escherichia coli (E.coli). They have proven to be problematic from its presence within the healthcare system especially when found on surgical site infections. From the statistics generated for the National Health Service (NHS) in the UK we can see that 52.4 % of S. aureus, and 43.1 % E.coli originates within the hospital environment. Antimicrobial activity was observed for several compounds under different light regimes on and off the solid support. As a result, the best observed MIC value of 0.25 mM/mL was achieved for S. aureus in darkness and in blue light without the polymer support. Additionally, when these compounds were linked to a polymer support (mimicking a bandage), antimicrobial activity was retained when irradiated using blue light at 1.0 mM/mL. These results show potential towards the next generation of antimicrobial disinfection agents. In time, these compounds could be integrated into the healthcare system for use as a new generation of self- cleaning bandages towards post-operative wound disinfection rather than employing front line antimicrobials. This is a moot subject under review in parliament and former UK prime minister has highlighted the concern. In a statement recently released, he states “If we fail to act, we are looking at an almost unthinkable scenario where antibiotics no longer work and we are cast back into the dark ages of medicine" – David Cameron, UK Prime Minister2.
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Stampouli, Dafni. "Improved qualification of vascular abnormalities in contrast enhanced magnetic resonance angiographic images." Thesis, University of Central Lancashire, 2009. http://clok.uclan.ac.uk/19967/.
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Stroke is the third leading cause of death in the western world, and the primary cause of adult disability. There is a great need for methods to identify patients at risk of stroke and decide appropriate treatment. The main criterion for identifying patients at risk of stroke is the percentage of the narrowing in the carotid arteries, which lead blood from the heart to the brain, which currently is quantified manually. This project is in collaboration with Blackpool Victoria Hospital and Christies Hospital in Manchester. The aim of this project is to develop software methods to improve computer-assisted carotid artery stenosis measurement based on Magnetic Resonance Images. A methodology is therefore presented, based on 3D geometry extracted from Contract-Enhanced MR Angiograms, to identify and segment the internal carotid arteries for stenosis quantification. The MRA data volume is initially automatically reduced, by locating the carotid arteries and creating two volumes of interest, each including a single set of carotids (either left or right). The artery of interest (Internal Carotid Artery - ICA) is identified in each sub-volume automatically, by tracking the carotid bifurcation and selecting the artery branch with no further arterial branches. The central axis of the ICA is consequently determined by calculating and connecting together the centres of gravity (centroids) of the 2D contours of the carotid in the axial plane. Segmentation of the ICA is carried out, perpendicular to the central axis, by applying adaptive thresholds along the ICA central axis based on local image characteristics. Hence, the cross-sectional area of the segmented ICA is then measured at different points along the vessel. The most stenotic area is identified, and a reference region is manually selected. The degree of stenosis is then quantified based on the reference and stenosed area measurements, according to the NASCET criterion. This provides a fully automated methodology to locate, identify, and measure the internal carotid stenosis. It is the first time that such complete methodology that covers the processing of the MRI data until the stenosis measurement is taken is developed and is fully automatic. The segmentation results are thoroughly evaluated against the manual delineations of two clinical experts (each performed the delineations twice), and against two popular segmentation techniques. The results were found successful and perform better than manual measurements and other current techniques. They present smaller variability than manual measurements and are able to deal with irregularities in the arterial structure, where other computerised techniques fail. The suggested methodologies seem promising and able to improve considerably both current clinical practice and other existing methodologies.
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Wodike, Obelema Tonbo Seddon. "Designing a value centred inspection method for children." Thesis, University of Central Lancashire, 2016. http://clok.uclan.ac.uk/16736/.
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There are currently several evaluation methods suited to children within the Child-Computer Interaction (CCI) community. However, these methods are user based leaving a gap in inspection method suited to children, that is, where children will act as the inspection method evaluators. This research focused on how to design an effective and easy to use inspection method where children will perform the evaluation based on their values. To ensure that the above is met, a user centred approach and a mixed methodology was explored and finally resulted in the creation of the Inspection Method for Children (IMCH) with an accompanying guideline. This six stages method could be used by CCI researchers as a guide to develop similar methods for children, by industries to perform inspection method evaluation with children on technologies designed for children and could be used by designers to gather design criteria for children’s technology. The process undertaken within this research to develop the new method is also novel and could be adapted by new and old researchers when adapting method to suit children. Future work will focus on carrying out evaluation with wider age range of children in the method to ensure suitability of the method for more children. Comparative studies of the method with other usability method to determine the effectiveness of the method and as a refinement process to produce a validated and refined IMCH method.
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McLarnon-Riches, Christian James. "The use of lipid profiles from immobilised Selenastrum capricornutum in the biological surveillance of freshwaters." Thesis, University of Central Lancashire, 2000. http://clok.uclan.ac.uk/19764/.
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The use of lipid profiles from the immobilised alga Selenastrum capricornuizim was investigated as a potential indicator of heavy metal pollution in freshwater environments. The toxicity of Cu", Zn 2 and Cd2t on algal growth was determined and the effective concentration inhibiting specific growth rate by 50 % (EC5 0) for each metal was found to be 124 pM Cu, 20 pM Zn and 5.7 pM Cd respectively. The Cu 24 EC50 value for immobilised cells was also shown to be 124 j.tM, suggesting that Cu exhibits similar toxic effects on growth in both free and immobilised cells. Studies of the effects of temperature and heavy metal exposure (Cu21, Zn 2 and Cd2 +) on S. caprzcornutum demonstrated that these factors altered the fatty acid and free sterol composition of free algal cells in batch culture. A shift in temperature from 25°C to 10°C led to an increase in the relative proportion of oleate and decrease in linoleate and parinate (18:4), together with a significant increase in the composition of ergostenol. Exposure to heavy metal ions led to an increase in oleate (with all three metals) and altered relative proportions of linoleate and parinate (changes being metal specific). Metal ion treatment also increased a22 desaturation of chondrillasterol. This characteristic lipid signature when S. capricornutum was exposed to heavy metal ions was significantly different from changes associated with other environmental factors. These changes in lipid composition upon heavy metal treatment were also observed during exposure of S. capricornuiwn to lower metal concentrations typically found in polluted environments. Studies of cells immobilised within alginate beads showed that gel confinement significantly affected the biochemistry and physiology of algal cells, with a reduction in growth rate and final cells numbers. Scanning electron microscopy demonstrated that growth was mainly limited to the bead periphery. Immobilisation altered the lipid of composition of cells as a consequence of alterations in membrane fluidity and membrane disruption. The Cu uptake from solution was greater in immobilised cells than free cells, thus gel confinement did not confer any protection to cells. The characteristic and significant changes within the lipid composition of free cells with Cu treatment were similarly observed in immobilised cells but were only apparent at 124 pM Cu. Thus lipid profiles, especially sterol composition of immobilised algal cells, may potentially be utilised as sensitive and novel indicators of heavy metal pollution in freshwater environments.
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Lu, Chen. "Expression profile of multidrug resistance genes and proteins in cancerous and stem cells." Thesis, University of Central Lancashire, 2008. http://clok.uclan.ac.uk/19754/.
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Despite improved knowledge and advanced treatments of high-grade gliomas, the overall survival rate of glioma patients remains low due to the recurrences and locations of the tumour. Evidence shows that the existence of a subpopulation of cells - cancer stem cells (CSCs) may be the major obstacle in treating gliomas. CD133 and nestin have been suggested as the markers of CSCs and natural stem cells. The primary focus of this study was to identify CD133+/nestin+ stem-like cells and discover their association with multidrug resistance (MDR) related genes, i.e. multiple drug resistance I (mdrl) gene and anti-apoptotic gene (bcl-2) in human glioma compared to normal brain tissues and cell lines. Glioma and normal astrocyte cell lines have been employed for CD133 isolating purposes to characterise the association with MDR related genotype and phenotype. The chemosensitivity of the isolated CD 133 population was investigated using chemosensitivity assay. Meanwhile, a serum deprivation method was established in this study to enrich and select CD 133+ CSCs in a glioma (GOS-3) cell line. As a secondary focus of this project, the possibility of immortalisation enzyme hTERT being a discriminative masker between normal and cancer brain stem cells and the transcriptional correlation between cd133 and bmi-lIc-myc oncogenes were investigated. For the first time, findings of the current study demonstrated that 1) there was an evident increase of CD133 gene expression in glioma compared to normal brain tissues where the latter expressed low levels of CD133, P-gp and Bcl-2 than glioma tissues, with an exception of nestin expression, 2) serum deprivation enriched CD133 expression and demonstrated a direct coexpression between CD133 and drug resistance in GOS-3 cells, 3) hTERT may not be a discriminative marker for normal and cancer brain stem cells, 4) although there was a strong transcriptional association between bmil and cmyc, there was an inverse transcriptional association between these genes and cd133 in serum deprived glioma cells, suggesting that bmil may not be essential for the maintenance of glioma stem cells, and 5) CD133+ glioma and normal brain cells showed a significantly high resistance towards chemotherapeutic drugs compared to the autologous CD133- cells. In conclusion, an improved understanding of molecules contributing to the maintenance of CSCs may lead to a combined treatment, targeting both CSCs and their protective MDR phenotypes leading eventually to attractive strategies for the treatment of gliomas.
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Woodruff, Kim Therese. "The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)." Thesis, University of Central Lancashire, 2004. http://clok.uclan.ac.uk/20248/.
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In the mammal, anaesthetics are known to act via two distinct mechanisms, either increasing inhibition via GABAA receptors (eg. Na-thiopentone) or decreasing excitation via NIvIDA receptors (eg. ketamine). The aim of this thesis is to investigate the effects of both increased inhibition and decreased excitation at the synaptic level within an invertebrate model system, something which cannot readily be done in vertebrate systems. This was achieved by carrying out experiments using both the above mentioned anaesthetics on the whole animal, isolated brain and cultured neurons. In invertebrates it has been shown that GABA and Glutamate can be both excitatory and inhibitory, and injection of GABA into Lymnaea has been shown to result in behavioural changes in feeding, locomotion, escape reactions, male mating and respiration. Injection of Na-thiopentone into the whole animal was carried out in this investigation, in order to establish the anaesthetic response of the animal model to this barbiturate. The presence of gamma-aminobutyric acid (GABA) receptors has been demonstrated in a respiratory interneuron (RPeD1) both electrophysiologically and via molecular techniques, however inmiunostaining has proved negative in RPeD1 and follower cells VD2/3 (unidirectional excitatory synapse) and VD4 (mutual inhibitory synapse). This suggests that these neurons are not themselves GABAergic, although this investigation shows the responses of these neurons to bath and direct application of GABA. Na-thiopentone did not reliably anaesthetise Lymnaea upon injection into the sole of the foot, suggesting that Na-thiopentone binds to proteins within the snail, andlor has a low affininty for the GABAA receptor in Lymnaea. Other anaesthetic studies using propofol and ketaniine have also demonstrated a lack of anaesthetic response. RPeD1 hyperpolarised and became quiescent in response to the application of high concentrations of GABA (10 3-104M), however at lower doses (1O 8-1O 5M), no effect was observed (p < 0.05). Under these conditions simultaneous recordings from VD4 showed hyperpolarisation in response to the application of GABA, whereas VD2 and VD3 exhibited excitatory responses. Presynaptic picoinjection of GABA also resulted in hyperpolarisation and quiescence in RJeD1, but the simultaneous response in VD3 was not observed. Postsynaptic application of GABA directly to 'VD2, and VD4 however, resulted in responses similar to those seen in the whole brain. VD2 and 3 also receive input 2, which hyperpolarises RPeD1 and elicits an excitatory EPSP in VD2 and 3 as this is similar to the response observed in this experiment it is possible that the effects of input 2 on RPeD1 and VD2 & 3 are mediated by GABA. As RPeDI does not stain positively for GABA and hyperpolarises in response to the drug, it seems unlikely that the postsynaptie effects are due to presynaptic release of GABA. RPeD1 has been shown to form reciprocal synapses with VD4 both in vivo and in vitro. When perfused with GABA (lmJ'i4), both cells hyperpolarised reversibly. The postsynaptic response could be due to the action of GABA presynaptically inhibiting RPeDI, or directly on postsynaptic GABA receptors. However VD4 forms connections with other cells in the brain such as input 3 which may also have resulted in this inhibitory response. RPeD1 would however have received a simultaneous excitatory input from this interneuron. Attempts were made to establish the nature of the RPeD1JVD4 synapse in these experiments, but no synapses were evident. These experiments therefore confirm the presence of GABA receptors in RPeD1 and suggest theft presence in VD2, and VD4. This investigation confirms the findings of previous studies, that injection and bath perfusion of barbiturates does not lead to responses in Lymnaea comparable to that of the mammal. In addition to it's main target site, ketamine (a frequently used intravenous anaesthetic) has also been shown to act at cholinergic receptors. The effects of ketamine on learning and memory and apoptosis in the mammalian CNS are well recognised. Within the Lymnaea CNS, VD4 and LPeD1 form a unidirectional excitatory cholinergic synapse, and this was chosen to investigate the effects of ketamine on excitatory synaptic transmission, short term potentiation and synapse formation in the invertebrate animal model. Ketamine decreased synaptic transmission between VD4 and LPeD1 in a concentration dependent manner, but did not significantly affect short term synaptic plasticity (pc0.05). While neurite outgrowth remained extensive, actual sprouting was diminished by all doses of ketamine. Cells exhibited extensive veiling, which was not present in control cells. Percentage chemical synapse formation was reduced by all doses of ketamine, and in some cases inappropriate inhibitory chemical synapses were formed. Furthermore acute, clinically relevant levels of ketamine reduce excitatory cholinergic transmission between VD4 and LPeD1, but short term plasticity is unaffected. Nerve regeneration was seriously compromised, and formation of appropriate chemical synapses greatly reduced. This data has serious implications for the clinical - use of ketamine, particularly in pregnant women, children or critical care patients where nerve regeneration and synapse formation are of great importance and long term exposure common practice. In conclusion, this work supports that of other studies which have showed that invertebrates appear to be relatively insensitive to barbiturates, whereas ketamine appears to effect excitation in a manner similar to that in the mammal.
Books on the topic "Space sciences not elsewhere classified"
1
Japan. Space cooperation: Manned space station : memorandum of understanding between the United States of America and Japan, signed at Tokyo May 9, 1985. Washington, D.C: Dept. of State, 1992.
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2
Japan. Space cooperation: Agreement between the United States of America and Japan, effected by exchange of notes signed at Washington October 24, 1996 with memorandum of understanding. [Washington, D.C.]: U.S. Dept. of State, 2006.
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3
Japan. Space cooperation: First Material Processing Test (FMPT) on Spacelab : agreement between the United States of America and Japan, effected by exchange of notes, signed at Washington March 29, 1985 with memorandum of understanding. Washington, D.C: Dept. of State, 1994.
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4
Japan. Fisheries, North Pacific driftnet: Agreement between the United States of America and Japan, effected by exchange of letters, signed at Tokyo and Washington, June 11 and 16, 1992 with attachment. Washington, D.C: Dept. of State, 1993.
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5
Japan. Defense: Agreement between the United States of America and Japan, amending the treaty of January 19, 1960, effected by exchange of notes, signed at Tokoyo December 26, 1990. Washington, D.C: U.S. Dept. of State, 1998.
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6
Japan. Defense assistance, FS-X weapon system: Agreement between the United States of America and Japan, effected by exchange of notes, signed at Tokyo November 29, 1988. Washington, D.C: Dept. of State, 1998.
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7
Japan. Defense assistance AN/ALQ-131 system: Agreement between the United States of America and Japan, effected by exchange of notes, signed at Tokyo March 12, 1993 with related letters. Washington, D.C: U.S. Dept. of State, 1998.
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Japan. Fisheries, North Pacific: Agreement between the United States of America and Japan, effected by exchange of letters, signed at Tokyo and Silver Spring, April 12, 1990, with annexes and attachment. Washington, D.C: Dept. of State, 1993.
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Japan. Defense: Agreement between the United States of America and Japan, signed at New York September 27, 1995 with agreed minutes and exchange of notes. Washington, D.C: U.S. Dept. of State, 2000.
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Japan. Defense assistance: Agreement between the United States of America and Japan effected by exchange of notes signed at Tokyo July 5, 1985. Washington, D.C: Dept. of State, 1995.
Find full textBook chapters on the topic "Space sciences not elsewhere classified"
1
M. Mugaviri, Blessing, Gilbert H. Moyo, Ezra Pedzisai, and Cuthbert Maravanyika. "Spatio-Temporal Distribution of the Black Rhino (Diceros bicornis L.) in the Midlands Black Rhino Conservancy, Zimbabwe." In Environmental Sciences. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106715.
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Geographic Information System (GIS) and Remote Sensing (RS) technologies have many attributes that are beneficial in detecting, mapping, and, monitoring change in Land use/Land cover (LULC). This study used the technology with the aim to evaluate the Spatio -temporal impacts of Land use/Land cover Changes (LULCC) on Black Rhino distribution in Midlands Black Rhino Conservancy (MBRC), Zimbabwe. The study used time series satellite data. Landsat images were downloaded for the month of May at five-year intervals from 2000 to 2020. LULC and Normalized Differences Vegetation Index (NDVI) maps obtained were used in change detection. The images were classified using QGIS software on the maximum likelihood classifier algorithm. Presents and absence data for Black Rhino was used for distribution mapping. Quantum Geographic Information System (QGIS) and, R studio software were used for analysis. Results indicated that, a big percentage cover change was the bare land which increased by over 160%. Woodland decreased by about 46% within the same space of time. LULCC showed a significant positive relationship with black rhino distribution (p = 0.0381). MOLUSCE plugin was used for Prediction of LULCC for the year 2030, results indicated the highest increase in bare land 16.59%.
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Bell, Duncan. "What is Liberalism?" In Reordering the World. Princeton University Press, 2016. http://dx.doi.org/10.23943/princeton/9780691138787.003.0003.
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This chapter attempts to reframe the way in which the liberal tradition is understood. It opens with a critique of some existing interpretive protocols used to delimit political traditions. It then introduces a new way of conceptualizing liberalism, suggesting that it can be seen as the sum of the arguments that have been classified as liberal, and recognized as such by other self-proclaimed liberals, across time and space. The second half of the chapter analyzes the emergence and subsequent transformation of the category of liberalism in Anglo-American political thought between 1850 and 1950. It traces the evolution of the language of liberalism in nineteenth-century Britain, and explores how the scope of the liberal tradition was massively expanded during the middle decades of the century, chiefly in the United States, such that it came to be seen by many as the constitutive ideology of the West. It argues that this broad understanding of liberalism was produced by a conjunction of the ideological wars fought against “totalitarianism” and assorted developments in the social sciences.
Conference papers on the topic "Space sciences not elsewhere classified"
1
Stone, E. "Mars and the search for life elsewhere - Innovations in the third era of space exploration." In 37th Aerospace Sciences Meeting and Exhibit. Reston, Virigina: American Institute of Aeronautics and Astronautics, 1999. http://dx.doi.org/10.2514/6.1999-2.
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