Academic literature on the topic 'Solutions solides – Stabilité – Solubilité'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Solutions solides – Stabilité – Solubilité.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Solutions solides – Stabilité – Solubilité":
El Ouenzerfi, R., C. Goutaudier, M. T. Cohen-Adad, G. Panczer, M. T. Ayedi, and N. K. Ariguib. "Solubilité de l'uranium dans les solutions solides d'apatite phospho-silicatée." Journal de Physique IV (Proceedings) 113 (January 2004): 111–14. http://dx.doi.org/10.1051/jp4:20040024.
Alpers, Charles N., Darell Kirk Nordstrom, and James W. Ball. "Solubility of jarosite solid solutions precipitated from acid mine waters, Iron Mountain, California, U.S.A. Solubilité des solutions solides de jarosite précipitées à partir des eaux minières acides, Iron Mountain, Californie, U. S. A." Sciences Géologiques. Bulletin 42, no. 4 (1989): 281–98. http://dx.doi.org/10.3406/sgeol.1989.1829.
Tanaka, Ryoma, Yusuke Hattori, Yukun Horie, Hitoshi Kamada, Takuya Nagato, and Makoto Otsuka. "Characterization of Amorphous Solid Dispersion of Pharmaceutical Compound with pH-Dependent Solubility Prepared by Continuous-Spray Granulator." Pharmaceutics 11, no. 4 (April 3, 2019): 159. http://dx.doi.org/10.3390/pharmaceutics11040159.
РЯЗАНЦЕВА, К. А., Н. Е. ШЕРСТНЕВА, Е. Ю. АГАРКОВА, and Н. А. ЖИЖИН. "INFLUENCE OF ULTRAVIOLET MODIFIED WHEY PROTEINS ON THE STABILITY OF THE STABILITY OF THE STABILIZED MILK CLOUD." Известия вузов. Пищевая технология, no. 2-3(392) (July 26, 2023): 83–92. http://dx.doi.org/10.26297/0579-3009.2023.2-3.14.
Sathisaran, Indumathi, and Sameer Dalvi. "Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium." Pharmaceutics 10, no. 3 (July 31, 2018): 108. http://dx.doi.org/10.3390/pharmaceutics10030108.
Zhang, Xuehong, Yinian Zhu, Honghu Zeng, Dunqiu Wang, Jie Liu, Huili Liu, Meifang Qian, and Liwei Xu. "Dissolution and solubility of the arsenate - phosphate hydroxylapatite solid solution [Ca5(PxAs1 - xO4)3(OH)] at 25°C." Environmental Chemistry 8, no. 2 (2011): 133. http://dx.doi.org/10.1071/en10102.
Mesmer, R. E., and C. F. Baes. "Review of Hydrolysis Behavior of Ions in Aqueous Solutions." MRS Proceedings 180 (1990). http://dx.doi.org/10.1557/proc-180-85.
Torrero, M. E., I. Casas, M. Aguilar, J. De Pablo, J. Gimenez, and J. Bruno. "The Solubility of Unirradiated UO2 In Both Perchlorate And Chloride Test Solutions. Influence of the Ionic Medium." MRS Proceedings 212 (1990). http://dx.doi.org/10.1557/proc-212-229.
YOUAN, Bi-Botti Celestin. "Systèmes nanoparticulaires : Applications phytopharmaceutiques et cosmétiques." Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB) 2, no. 3 (December 20, 2023). http://dx.doi.org/10.57220/jatpb.v2i3.116.
Tripathi, Devika, Manjunatha Prabhu B.H, Jagannath Sahoo, and Jyoti Kumari. "Navigating the Solution to Drug Formulation Problems at Research and Development Stages by Amorphous Solid Dispersion Technology." Recent Advances in Drug Delivery and Formulation 17 (December 7, 2023). http://dx.doi.org/10.2174/0126673878271641231201065151.
Dissertations / Theses on the topic "Solutions solides – Stabilité – Solubilité":
Samsoen, Simon. "Synthèses et caractérisations physiques de matrices polymères pour la formulation de dispersions solides amorphes curcumine/polyvinylpyrrolidone." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDSMRE/2024/2024ULILR001.pdf.
This thesis aims at improving our fundamental knowledge on the mechanisms involved in the formation of amorphous solid dispersions (ASD) of a drug within a polymer excipient, in particular the impact of the macromolecular architecture on the physical stability of ASD.Poly(N-vinylpyrrolidone) (PVP) polymers with low dispersity and different molar masses and chain-end functionalities are first synthesised in a controlled manner by RAFT/MADIX (Reversible Addition-Fragmentation chain Transfer/ Macromolecular design by Interchange of Xanthates). They are then used to formulate, by co-milling and solvent evaporation processes, mixtures with curcumin (CUR). The advanced physico-chemical characterisation of PVP, CUR and the obtained ASD enables us to establish the CUR/PVP phase (solubility limit) and state (glass transition temperature (Tg) evolution) diagrams. On the one hand, this diagram allows us to better understand the stability conditions of CUR/PVP ASD and the impact of the PVP molar mass and chain-end functionality. On the other hand, comparison with ASD formulated with high dispersity commercial PVP allows us to highlight the specific role of the dispersity on the Tg of PVP and of CUR/PVP ASD. Indeed, for ASD formulated with high dispersity PVP, results show the decrease of Tg at high PVP contents, which unveils a competition between the development of attractive interactions between CUR and PVP and a plasticising effect induced by the broad distribution of PVP molar masses. Finally, this work reveals that the use of PVP synthesised in a controlled manner allows to obtain stable ASD over a broader range of temperatures and CUR concentrations than for ASD formulated with industrially available PVP of high dispersity
Costin, Dan Tiberiu. "Solutions solides d'uranothorites : De la préparation à la dissolution." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2012. http://www.theses.fr/2012ENCM0026/document.
USiO4 coffinite appears as one of the potential phases formed in the back-end of the alteration of spent fuel, in reducing storage conditions. A study aiming to assess the thermodynamic data associated with coffinite through an approach based on the preparation of Th1-xUxSiO4 uranothorite solid solutions was then developed during this work. First, the preparation of uranothorite samples was successfully undertaken in hydrothermal conditions. However, the polyphased samples systematically formed for x > 0,2 underlined the kinetic hindering linked with the preparation of uranium-enriched samples, including coffinite end-member. Nevertheless, the characterization of the various samples led to confirm the formation of an ideal solid solution and allowed the constitution of a spectroscopic database. The purification of the samples was then performed by the means of different protocoles based on physical (dispersion-centrifugation) or chemical (selective dissolution of secondary phases) methods. This latter led to a complete of the impurities (Th1-yUyO2 mixed oxide and amorphous silica) through successive washing steps in acid then basic media. Finally, dissolution experiments were undertaken on uranothorite samples (0 ≤ xexp. ≤ 0,5) and allowed pointing out the influence of composition, pH and temperature on the normalized dissolution rate of the compounds. Also, the associated thermodynamic data, such as activation energy, indicate that the reaction is controlled by surface reactions. Once the equilibrium is reached, the analogous solubility constants were determined for each composition studied, then allowing the extrapolation to coffinite value. It was then finally possible to conclude on the inversion of coffinitisation reaction with temperature
Dubois, Rémy. "Investigation numérique de la stabilité et de la solubilité des solides pharmaceutiques amorphes visant à améliorer la biodisponibilité des médicaments." Thesis, Lille 1, 2013. http://www.theses.fr/2013LIL10062/document.
Most of the active pharmaceutical ingredients and excipients are generally formulated in solid state which may exist under several different forms including crystalline polymorphs and amorphous forms. Such forms can exhibit different behaviors and have significant impact on the therapeutical efficiency and the stability of the drug product. This thesis was mainly motivated by the fundamental and practical difficulties that remained unsolved by the actual state of the art in pharmaceutical science. A fundamental approach has thus been necessary and a research program on solid state physics of basic pharmaceutical compounds (small organic molecules) has been conducted on: - Prediction of stability of crystalline polymorphs of pharmaceutical compounds;- Physical properties of interfacial water in contact with crystalline and amorphous materials;- Aggregation kinetic of a model pharmacutical compound
Janvier, Catherine. "Solutions solides de zirconium dans la cérine : modèle thermodynamique et stabilité thermique a haute température." Phd thesis, Ecole Nationale Supérieure des Mines de Saint-Etienne, 1998. http://tel.archives-ouvertes.fr/tel-00841807.
Janvier, Catherine. "Solutions solides de zirconium dans la cérine : modèle thermodynamique et stabilité thermique à haute température." Grenoble INPG, 1998. http://tel.archives-ouvertes.fr/tel-00841807.
Fikar, Ondřej. "Ab initio výpočty křivek rozpustnosti tuhých roztoků." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-400461.
Costenoble, Sylvain. "Modélisation de la coprécipitation d'oxalates mixtes d'uranium et de plutonium dans le cadre du recyclage du combustible nucléaire : solubilité des solutions solides oxalate." Thesis, Lille 1, 2009. http://www.theses.fr/2009LIL10179/document.
Chemical processes for future spent fuel treatment and recycling for new generation facilities are oriented on uranium and plutonium co-management. In the COEX TM process, one of the key operation consists of uranium(IV)-plutonium(III) co-conversion by oxalic co-precipitation. This leads to a mixed oxide for fuel production via the synthesis and the calcination of an oxalate solid solution precursor. Oxalic coprecipitation modeling, support of a better understanding of the process, is based on the supersaturation calculation whose expression is a function of thermodynamic data related to the oxalate solid solution formation.These thermodynamic data are acquired thanks to solubility measurements realised on uranium(IV)-neodymium(III) oxalate solid solutions, where neodymium(III) simulates the plutonium(III) behaviour. From the development of an actinide speciation analytical method, the non congruent interaction between the solid solution phase and the aqueous phase is observed. On the basis of the reaction constants of the occurring equilibria, a model, extracted from the LIPPMANN’s theory, allows to predict the state of the solid solution-aqueous solution system at thermodynamic equilibria. This methodology was extended to mixed oxalates U(IV)-Pu(III) and U(IV)-Am(III) demonstrating the model validity for these systems
Nadaud, Camille. "Amélioration de la solubilité de principes actifs BCS classe 2 par obtention de dispersions solides." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2016. http://www.theses.fr/2016EMAC0001.
The aqueous solubility of new chemical entities is increasingly weak, due to their complex structure, and many API fail in development due to insufficient solubility. Many technologies exist to enhance the solubility and / or dissolution of such compounds in aqueous media. Among all of these methods, this thesis is focused on the formulation of amorphous solid dispersions by hot melt extrusion. A lot of matrix can be used to formulate with this technology, so few methods to estimate miscibility between API and matrices will also be presented in this thesis. Finally, a study about the hot melt extrusion process will also be presented
Thakare, Kalpana. "THE EVALUATION OF LARCH ARABINOGALACTAN AS A NEW CARRIER IN THE FORMULATION OF SOLID DISPERSIONS OF POORLY WATER- SOLUBLE DRUGS." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/232942.
Ph.D.
Advanced drug discovery techniques have produced more lipophilic compounds. Formation of an amorphous solid dispersion of such poorly water-soluble drugs improves their solubility and dissolution. This results in greater in vivo bioavailability. Thus, it is one of the recent trends in the development of oral dosage forms. In solid dispersions, the carrier is crucial for ensuring the functionality and stability of these systems. Larch arabinogalactan FiberAid grade (AGF) is generally recognized as safe (GRAS) designated, amorphous polymer. The objective of this dissertation project was to perform a comprehensive evaluation of AGF as a carrier for amorphous solid dispersions. First, a detailed characterization of the AGF polymer was performed. A special focus on its use as a solid dispersion carrier was emphasized. The glass transition temperature and the degradation temperature of the AGF polymer were ~82 oC and ~185 oC, respectively. The AGF polymer had good hygroscopicity. Ibuprofen-AGF solid dispersions were evaluated for dissolution enhancement. Ibuprofen-Hydroxypropyl methylcellulose grade K3 (HPMCK3) solid dispersions were investigated simultaneously as a control polymer dispersion. The ibuprofen-AGF solid dispersions were amorphous at nearly 20% ibuprofen load. The dissolution of the ibuprofen from AGF solid dispersions was significantly greater than that of the neat ibuprofen. The formation of the amorphous state of ibuprofen and solution-state ibuprofen-AGF interactions were the mechanisms of the ibuprofen dissolution enhancement. At a 10% ibuprofen load, the dissolution of the AGF solid dispersion was found greater than that of the dissolution of the HPMCK3 solid dispersion. Secondly, the itraconazole-AGF solid dispersions and the ketoprofen-AGF solid dispersions were characterized and compared them with the ibuprofen-AGF solid dispersions. The comparisons were established for the miscibility and dissolution enhancement. The order of increase in dissolution was ketoprofen-AGF solid dispersions > itraconazole-AGF solid dispersions> ibuprofen-AGF solid dispersions. The same order was observed for the solid-state miscibility of these drug-AGF solid dispersions. Additionally, the solid dispersions of 9 drugs with the AGF polymer were investigated to elucidate the detailed mechanism of drug crystallization inhibition by the AGF polymer. The inherent tendency of the AGF polymer to inhibit the drug crystallization, drug-AGF solid-state hydrogen bonding and the anti-plasticizing effect of AGF were the mechanisms underlying the crystallization inhibition by the AGF polymer. Last, a storage stability of ibuprofen-AGF amorphous solid dispersions after storage under accelerated conditions (for 3 months) and ambient conditions (for 6 months) was investigated. The amorphous ibuprofen from AGF solid dispersions was physically and chemically stable under stability conditions. In summary, the AGF polymer was evaluated as a novel carrier for formation of an amorphous solid dispersions. The studies established that the AGF polymer was comparable to HPMCK3 polymer. The AGF polymer could be more advantageous than the HPMC polymer for the preparation of solid dispersion when faster dissolution is desired at lower drug load.
Temple University--Theses
Aumelas, Angeline. "Broyage de composés pharmaceutiques : changements d'états physiques et manipulation de la stabilité." Thesis, Lille 1, 2008. http://www.theses.fr/2008LIL10160/document.
Ln this thesis, a study of an active pharmaceutical ingredient (APl), weakly soluble in water, is reported. Its formulation in the amorphous state would be a means to increase its solubility. First, we showed that the polymorphism of this compound is more complex than the two forms, 1 (stable) and II (metastable), till now known and linked together by a monotropic relation. Two new metastable polymorphic forms were revealed by calorimetry and X-ray diffraction. Then, we showed that the milling of the APl stable form 1 induces its amorphization. The obtained glass has the same structural characteristics than the quenched liquid. However, it is not stable and crystallizes, on heating, just after the glass transition and in a few days when stored under ambient temperature and humidity. We tried to stabilize the amorphous APl by co-amorphization with an amorphous polymeric excipient (HPMC) and with a crystalline molecular excipient (anhydrous trehalose). Homogeneous amorphous solid solutions and molecular alloys, unreachable by the meltinglquenching process, were obtained by co-milling for any composition of the mixtures excipient/API(form 1). The stability on heating of these glass solutions was really enhanced. During storages, the HPMCIAPI glass solutions present a better stability than the trehalose/API vitreous alloys (stability of 2 years under ambient temperature and humidity). This investigation shows that the glass transition temperature value is not a sufficient parameter to predict the stability of amorphous compounds. A mechanism for the amorphization by milling is proposed
Book chapters on the topic "Solutions solides – Stabilité – Solubilité":
Dewangan, Smriti, Moonmun Dhara, and Varsha Rawat. "NANOTECHNOLOGY BASED APPROACHES FOR ENHANCING BIOAVAILABILITY OF POORLY SOLUBLE DRUGS." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 3, 245–77. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn3ch14.
Kasturi, Madhavi. "Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs." In Drug Formulation Design [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108706.
Kumar, Keshav, Dr Rupali Sharma, Dr Satish Sardana, Mr Shekhar Sharma, and Dr M. Aamir Mirza. "DOSAGE FORM DESIGN." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 14, 79–84. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkpn14p1ch6.
Conference papers on the topic "Solutions solides – Stabilité – Solubilité":
Rautiola, Davin, and Ronald A. Siegel. "Nasal Spray Device for Administration of Two-Part Drug Formulations." In 2019 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/dmd2019-3216.
Branagan, D., J. Buffa, and M. Maston. "Advanced Nanoscale Neutron Absorber Coatings for Safe Longterm Storage of Spent Nuclear Fuel and Nuclear Waste." In ITSC2005, edited by E. Lugscheider. Verlag für Schweißen und verwandte Verfahren DVS-Verlag GmbH, 2005. http://dx.doi.org/10.31399/asm.cp.itsc2005p0551.
Khan, Md Ashraful Islam, Iván Darío Piñerez Torrijos, Saja Hussam Aldeen Algazban, Skule Strand, and Tina Puntervold. "Polysulphate: A New Eor Additive to Maximize the Oil Recovery from Carbonate Reservoirs at High Temperature." In ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211443-ms.