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Humphries, Catherine L. "Devocioun of chastite to love : the devotional language of virginity in some thirteenth- and fourteenth-century texts." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342633.
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Dong, L. (Li). "Identifying the requirements of elderly solitaries in China for interactive smart home design." Master's thesis, University of Oulu, 2016. http://urn.fi/URN:NBN:fi:oulu-201605221864.
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Context: In recent decades, more than 200 million rural-to-urban migrants of working-age moved to and temporarily lived in cities in China. This migration contributes to the so-called empty nest phenomenon (i.e., changes in psychological well-being of parents when children leave their home). As time goes on, many of the empty-nest elderly will be in the statement of spouse-bereft and living alone. Compared with elderly people who live with their spouses, elderly solitaries have relatively worse psychological status. Most of existing smart home designs for the elderly are focusing on performing different functions packaged into friendly user interfaces, but emotional perspectives are scantly taken into account or are ignored.
Aim: This thesis aims to explore the real demands of elder people living alone in China in order to inform the design of smart home systems that satisfy both physical needs and psychological needs.
Method: The research procedure obeys the human-centred lifecycle model steps starting from identifying needs for design, to understanding the context of use, to completing requirements specification work. A literature review on existing smart home modes for the elderly was conducted to collect requirements defined by previous researches. In addition, 22 field interviews in three groups (elderly solitaries over 60, elderly between 50–60, and children generation of elderly solitaries) were conducted in Xiamen city of China for gathering and analyzing the real demands. Requirements are finalized by integrating prior studies and the interview data analysis.
Results: I found that for older people (over 60 years old), their needs and expectations mainly form four aspects: they wish they could live orderly (daily life), could keep aware of their body condition (health care), could be rescued in time once emergency occurs (emergency response), and could have initiative contacts frequently with their children (emotional solace). Compared with them, the elderly between 50–60 have demands for higher quality lives. They have the ability to operate intelligent products, and squint towards the conjunction of online and offline lifestyles to enrich their life. As for the children generation, they wish their parents could have the resources to develop their own interests and have friends around as companions.
Contribution and future work: This thesis makes contribution to the design of smart home systems for the elderly by providing comprehensive requirements. Possible future research extension can be the realization of smart home system based on the requirements gathering in thesis.
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Argüelles, Cristian Darío. "Consumidores y solitarios." Bachelor's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales, 2012. http://bdigital.uncu.edu.ar/5363.
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Las relaciones interpersonales de la actualidad presentan rasgos que las asemejan a relaciones de consumo, descartables e inestables y en las que se entrevé un creciente grado de desinterés hacia el otro.
Partimos desde una descripción de la posmodernidad, del modelo de sujeto que ella privilegia y de una caracterización de las relaciones interpersonales que se tejen en este marco para contraponer un modelo de comunicación diferente, basado en el trabajo de Antonio Pasquali.Fil: Argüelles, Cristian Darío. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales.
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Liriano, Castro Orieta del Corazón de Jesús. "Subgrupos solitarios de grupos finitos." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/59397.
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[EN] The scope of this thesis is the abstract finite group theory. All the groups we will consider will be finite. hence, the word "group" will be understood as a synonimous of "finite group". We say that a subgroup H of a group G is solitary when no other subgroup of G is isomorphic to H. A normal subgroup H of a group G is said to be normal solitary when no other normal subgroup of G is isomorphic to H. A normal subgroup N of a group G is said to be quotient solitary when no other normal subgroup K of G gives a quotient isomorphic to G/N. Solitary subgroups, normal solitary subgroups, and quotient solitary subgroups have been recently studied by authors like Thévenaz, who named the solitary subgroups as strongly characteristic subgroups, Kaplan and Levy, Tarnauceanu, and Atanasov and Foguel.
The aim of this PhD thesis project is to deepen into the analysis of these subgroup embedding properties, by refining the knowledge of their lattice properties, by obtaining general properties related to classes of groups, and by analysing groups in which the members of some distinguished families of subgroups satisfy these embedding properties.
The basic results of group theory that will be used in the memoir appear in Chapter 1. Among them, we comment on some results about soluble groups, supersoluble groups, nilpotent groups, classes of groups, and p-soluble and p-nilpotent groups for a prime p. In Chapter 2, we present the basic concepts about these embedding properties, as well as some basic results satisfied by them.
Chapter 3 is devoted to the study of lattice properties of these types of subgroups. In this chapter we deepen into the study of the lattices of solitary subgroups and quotient solitary subgroups developed by Kaplan and Levy and by Tarnauceanu and we check that, even though these lattices consist of normal subgroups, they are not sublattices of the lattice of normal subgroups. We also check that the set of all normal solitary subgroups does not constitute a lattice, which motivates the introduction of the concept of subnormal solitary subgroup as a more suitable tool to deal with lattice properties.
In Chapter 4, we study in depth the relations between these embedding properties and classes of groups. We observe that the subnormal solitary subgroups behave well with respect to radicals for Fitting classes and that the residuals for formations are quotient solitary subgroups. We also study conditions under which the radicals with respect to Fitting classes are quotient solitary subgroups and the residuals with respect to formations are solitary subgroups. To finish, we state the natural question of whether the solitary or subnormal solitary subgroups can be regarded as radicals for suitable Fitting classes or whether the quotient solitary subgroups are residuals for suitable Fitting classes. We give a negative answer to this question.
Chapter 5 is devoted to the study of groups whose minimal subgroups are solitary, that is, groups with a unique subgroup of order p for each prime p dividing its order. We give a complete classification of these groups and we make some remarks about related problems.
Our contributions to this research line have been accepted for their publication in two papers in Communications in Algebra and in Journal of Algebra and its Applications.[ES] El ámbito de esta tesis es el de la teoría abstracta de grupos finitos. Todos los grupos que consideremos serán finitos. Por ello, la palabra «grupo» se entenderá como sinónima de «grupo finito». Decimos que un subgrupo H de un grupo G es solitario cuando ningún otro subgrupo de G es isomorfo a H. Un subgrupo normal H de un grupo G se dice normal solitario cuando ningún otro subgrupo normal de G es isomorfo a H. Un subgrupo normal N de un grupo G se dice que es solitario para cocientes cuando ningún otro subgrupo normal K de G da un cociente isomorfo a G/N. Los subgrupos solitarios, los subgrupos normales solitarios y los subgrupos solitarios para cocientes han sido recientemente estudiados por autores como Thévenaz, quien bautizó los subgrupos solitarios como subgrupos fuertemente característicos, Kaplan y Levy, Tarnauceanu y Atanasov y Foguel. El objeto de este proyecto de tesis doctoral es el de profundizar en el análisis de estas propiedades de inmersión de subgrupos, afinando en el conocimiento de sus propiedades reticulares, obteniendo propiedades generales en relación con clases de grupos y analizando grupos en los que los miembros de algunas familias destacadas de subgrupos satisfacen estas propiedades de inmersión. Los resultados básicos de teoría de grupos que se utilizan en la memoria aparecen en el capítulo 1. Entre ellos, comentamos algunos resultados sobre grupos resolubles, superresolubles, nilpotentes, clases de grupos y grupos p-resolubles y p-nilpotentes para un primo p. En el capítulo 2 presentamos los conceptos básicos sobre estas propiedades de inmersión, así como algunos resultados básicos que satisfacen. El capítulo 3 está dedicado al estudio de propiedades reticulares de estos tipos de subgrupos. En este capítulo se profundiza en el estudio de los retículos de subgrupos solitarios y solitarios para cocientes llevado a cabo por Kaplan y Levy y por Tarnauceanu y se comprueba que, a pesar de que estos retículos constan de subgrupos normales, no son subretículos del retículo de subgrupos normales. También comprobamos que el conjunto de subgrupos normales solitarios no constituye un retículo, lo que motiva la introducción del concepto de subgrupo subnormal solitario como herramienta más adecuada para tratar propiedades reticulares. En el capítulo 4 estudiamos con profundidad las relaciones entre estas propiedades de inmersión y clases de grupos. Observamos que los subgrupos subnormales solitarios se comportan bien respecto de radicales de clases de Fitting y que los residuales para formaciones son subgrupos solitarios para cocientes. Esto permite mejorar algunos resultados sobre subgrupos solitarios para cocientes. También estudiamos condiciones en que los radicales respecto de clases de Fitting son subgrupos solitarios para cocientes y los residuales respecto de formaciones son subgrupos solitarios. Por último, nos planteamos la cuestión natural de si los subgrupos solitarios o subnormales solitarios pueden verse como radicales para clases de Fitting adecuadas o si los subgrupos solitarios para cocientes son residuales para clases de Fitting adecuadas. Damos una respuesta negativa a esta cuestión. El capítulo 5 está dedicado al estudio de grupos cuyos subgrupos minimales son solitarios, es decir, grupos con un único subgrupo de orden p para cada primo p divisor de su orden. Damos una clasificación completa de estos grupos y hacemos algunas observaciones sobre problemas relacionados. Nuestras aportaciones a esta línea de investigación han sido aceptadas para su publicación en dos artículos en Communications in Algebra y en Journal of Algebra and its Applications.
[CAT] L'àmbit d'aquesta tesi és el de la teoria abstracta de grups finits. Tots els grups que hi considerem seran finits. Per això, la paraula «grup» s'entendrà com a sinònima de «grup finit». Direm que un subgrup H d'un grup G és solitari quan cap altre subgrup de G no és isomorf a H. Un subgrup normal H d'un grup G es diu normal solitari quan cap altre subgrup normal de G no és isomorf a H. Un subgrup normal N d'un grup G es diu que és solitari per a quocients quan cap altre subgrup normal K de G no dóna un quocient isomorf a G/N. Els subgrups solitaris, els subgrups solitaris normals i els subgrups solitaris per a quocients han sigut recentment estudiats per autors com Thévenaz, qui batejà els subgrups solitaris com a subgrups fortament característics, Kaplan i Levy, Tarnauceanu i Atanasov i Foguel. L'objecte d'aquest projecte de tesi doctoral és el d'aprofundir en l'anàlisi d'aquestes propietats d'immersió de subgrups, afinant en el coneixement de les seues propietats reticulars, obtenint propietats generals en relació amb classes de grups i analitzant grups en què els membres d'algunes famílies destacades de subgrups satisfan aquestes propietats d'immersió. Els resultats bàsics de teoria de grups que es fan servir en la memòria apareixen al capítol 1. Entre ells, comentem alguns resultats sobre grups resolubles, superresolubles, nilpotents, classes de grups i grups p-resolubles i p-nilpotents per a un primer p. Al capítol 2 presentem els conceptes bàsics sobre aquestes propietats d'immersió, així com alguns resultats bàsics que satisfan. El capítol 3 està dedicat a l'estudi de propietats reticulars d'aquests tipus de subgrups. En aquest capítol s'aprofundeix en l'estudi dels reticles de subgrups solitaris i solitaris per a quocients dut a terme per Kaplan i Levy i per Tarnauceanu i es comprova que, encara que aquests subgrups consten de subgrups normals, no són subreticles del reticle de subgrups normals. També comprovem que el conjunt de subgrups normals solitaris no constitueix un reticle, la qual cosa motiva la introducció del concepte de subgrup subnormal solitari com a eina més adient per tractar propietats reticulars. Al capítol 4 estudiem amb profunditat les relacions entre aquestes propietats d'immersió i classes de grups. Observem que els subgrups subnormals solitaris es comporten bé respecte de radicals de classes de Fitting i que els residuals per a formacions són subgrups solitaris per a quocients. Açò permet millorar alguns resultats sobre subgrups solitaris per a quocients. També estudien condicions en què els radicals respecte de classes de Fitting són subgrups solitaris per a quocients i els residuals respecte de formacions són subgrups solitaris. Per acabar, ens plantegem la qüestió natural de si els subgrups solitaris o subnormals solitaris poden veure's com a radicals per a classes de Fitting adients o si els subgrups solitaris per a quocients són residuals per a classes de Fitting adients. Donem una resposta negativa a aquesta qüestió. El capítol 5 està dedicat a l'estudi de grups els subgrups minimals dels quals són solitaris, és a dir, grups amb un únic subgrup d'ordre p per a cada primer p divisor del seu ordre. Donem una classificació completa d'aquests grups i fem algunes observacions sobre problemes relacionats. Les nostres aportacions a aquesta línia de recerca han sigut acceptades per a llur publicació a dos articles a Communications in Algebra i a Journal of Algebra and its Applications.
Liriano Castro, ODCDJ. (2015). Subgrupos solitarios de grupos finitos [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/59397
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FENG, LIN. "MODULATION OF SYNAPTIC TRANSMISSION AT THE NUCLEUS TRACTUS SOLITARIUS." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/816.
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The caudal nucleus tractus solitarius (cNTS) is the key recipient of the primary afferents from visceral sensory neurons and also an important site that processes and integrates gastrointestinal, cardiovascular and respiratory functions. Glutamate and gamma-aminobutyric acid are the major neurotransmitters within the NTS, but studies have suggested that nicotinic acetylcholine receptors (nAChRs) and transient receptor potential (TRP) channels can modulate excitatory/inhibitory neurotransmission. I have designed studies to understand the role of nAChRs and TRP channels in the modulation of neurotransmission in the cNTS. In the first aim, experiments were designed to test the hypothesis that the cNTS contains function-specific subsets of neurons whose responsiveness to nicotine correlates with the target of their axonal projections. cNTS neurons send axonal projections to brain regions such as parabrachial nucleus (PBN), hypothalamic paraventricular nucleus (PVN), nucleus ambiguous (NA), dorsal motor nucleus of the vagus (DMV) and the caudal ventrolateral medulla (CVLM) and are involved in integrating autonomic and neuroendocrine functions. Presynaptic/postsynaptic modulation by nAChRs differ in the axonal projections of cNTS neurons, studying of which would provide better understanding of this complex integration. In vivo fluorescent tracing combined with in vitro slice patch-clamp electrophysiological recordings from anatomically identified caudal NTS neurons were used to study the expression and function of nAChRs (mainly á3â4 containing nAChRs) in the cNTS. Results from these studies demonstrate that presynaptic and postsynaptic responsiveness of caudal NTS neurons to nicotine correlates with the areas the neurons project to in the following order of prevalence: DMV>PVN>NA>CVLM>PBN (for presynaptic responses) and DMV>CVLM>PBN>NA>PVN (for postsynaptic responses). In the second aim, experiments were designed to test the hypothesis that nociceptive TRP channels TRPV1 (vanilloid) and TRPA1 (ankyrin) modulate synaptic transmission in the NTS. As a result of this modulation, the efferent functions that control autonomic and visceral functions will be regulated and account for the changes in autonomic neuropathy as patients with diabetes develop significant alterations in blood pressure and heart rate as well as silent myocardial ischemia as a result of blunted pain carrying ability. Results obtained from these studies demonstrated that TRPV1 and TRPA1 mRNA were detected in the dorsal root ganglion (DRG), but not in the NTS. Immunofluorescence studies revealed that TRPV1 and TRPA1 were expressed in the solitary tract central sensory terminals inputs to NTS but not in NTS neurons. This suggests that TRPV1 and TRPA1 are expressed only in solitary tract. Administration of capsaicin (TRPV1 agonist) and allyl isothiocyanate (AITC, TRPA1 agonist) both increased the frequency of s/mEPSCs without affecting spontaneous and miniature inhibitory postsynaptic currents (s/mIPSCs). Next, the modulation of TRPV1- and TRPA1-induced responses by utilizing a PKC activator (PDBu) was examined. Incubation of slices with PDBu synergistically increased the mEPSC frequency following capsaicin application suggesting an increased receptor affinity; however following application of AITC there was no significant change, suggesting that activation by covalent modification does not enhance binding affinity. Finally, the specificity of TRPV1 and TRPA1 effect on synaptic transmission by ablating TRPV1 and TRPA1were tested. There was no modulation of synaptic transmission in these animals, further confirming that capsaicin- and AITC-mediated modulation of synaptic transmission are specifically mediated by TRPV1 and TRPA1, respectively. Furthermore, animals with painful diabetic peripheral neuropthy exhibited enhanced synaptic activity at the NTS, suggesting a role in nociception and other visceral functions. In summary, nAChRs, TRPV1 and TRPA1 are expressed in the NTS and activation of which modulate excitatory synaptic transmission. The results obtained from these studies and their interpretation may provide a better understanding of the central mechanism of modulation on efferent functions from NTS that regulate cardiovascular, respiratory and gastrointestinal functions.
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Contreras, Arratia Rodrigo Andrés. "Propagación de ondas solitarias en medios estratificados: teoría y observaciones." Tesis, Universidad de Chile, 2013. http://www.repositorio.uchile.cl/handle/2250/115270.
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Magíster en Ciencias, Mención GeofísicaLa teoría clásica en sismología que explica la transmisión de ondas en un medio elástico se sustenta sobre las bases de la ley de Hooke, la cual relaciona linealmente los esfuerzos aplicados a un cierto sólido con la deformación que éste sufre. Si bien ésta es válida en la mayoría de los casos, es posible que no explique todos los fenómenos ondulatorios en medios elásticos. Para algunos casos es necesaria una relación constitutiva que incluya términos de mayor orden, o términos nolineales. Esto es posible debido a la existencia de una relación entre la Energía Interna de Deformación y los invariantes del tensor de deformación. El trabajo teórico desarrollado en este estudio incorpora la transmisión de ondas dispersivas en un medio nolineal, la cual entrega ecuaciones diferenciales nolineales. Éstas, bajo ciertas condiciones, presentan soluciones de Ondas Solitarias, es decir, son ondas viajeras que no pierden su forma de onda a medida que se propagan. Las soluciones a los modelos presentan velocidades de fase levemente mayores a la velocidad de la onda S, periodos cercanos a los 150 s, deformaciones permanentes y amplitudes de onda inversamente proporcionales a la raíz de los coeficientes de nolinealidad. Estas ondas se observan principalmente en zonas cercanas al hipocentro de sismos de magnitud moderada y donde las rocas se comporten nolinealmente con endurecimiento, esto significa que a medida que los esfuerzos aplicados sean mayores, la roca será más dificil de deformar. Estos resultados se comparan con observaciones de sismos registrados en Estados Unidos: un sismo Mw 5.1 ocurrido el 29 de Septiembre del 2004 y otro Mw 4.8 que ocurrió el 8 de octubre del 2006. El análisis de señales comprende: pruebas de ruido que muestran que las señales son parte del sismo y no ruido sísmico ambiente, gráficos distancia vs tiempo que muestran una velocidad de fase relativamente constante para la onda y estudios de polarización y amplitudes esperadas en cada estación que muestran movimientos de partícula concordante con el 50% de los datos. En las réplicas estudiadas del terremoto de Chile del 27 de Febrero del 2010, de los registros estudiados, no se observaron las señales de periodo largo, lo cual muestra que la geología de Chile no cumple las condiciones necesarias para la propagación de ondas solitarias. Por otro lado, al revisar la literatura se puede establecer que sismos de profundidad intermedia y mayor no generan estas ondas de baja frecuencia, sólo se observan en sismos superficiales (intraplaca). Es por esto que no se espera observar estas señales en las réplicas del terremoto de Chile. Si bien estos resultados muestran que hay observaciones que cumplen con las condiciones del modelo, no es una conclusión definitiva. Se deben realizar más pruebas para demostrar que la totalidad de los datos sean consistentes con la teoría, éstas deben incluír: estudios de la reología de la zona y estudios de otros procesos nolineales en la zona de ruptura del terremoto.
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De, Roo Ryan Thomas. "Pragmatic strategy of amphicarpic Sedge Trianoptiles solitaria." Thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24961.
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Maubach, Karen Ann. "The role of tachykinins in synaptic transmission in the nucleus tractus solitarius." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306881.
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Wilkinson, Katherine Anne. "Contributions of the Nucleus Tractus Solitarius to ventilatory acclimatization to chronic hypoxia." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3356136.
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Thesis (Ph. D.)--University of California, San Diego, 2009.Title from first page of PDF file (viewed June 15, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 84-97).
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Hosford, P. S. "The cardiovascular regulatory role of 5-HT in the nucleus tractus solitarius." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1430689/.
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The nucleus tractus solitarus (NTS) integrates afferent information to maintain cardiovascular homeostasis. Pharmacological experiments have indicated that 5-HT is released in this process. In vitro and in vivo experiments were carried out to measure this release. 5-HT was detected in the NTS indirectly, by measuring glutamatergic inward currents in the slice and directly by voltammetry in the anaesthetised rat. In the slice, the presence of tonic release of 5-HT was confirmed which, in part, is responsible for basal release of glutamate via activation of 5-HT3 receptors. Blockade of the high-affinity, low-capacity 5-HT transporter (5-HTT; SERT), with citalopram and the low-affinity, high-capacity transporters (organic cation transporter 3; OCT3 and the plasma membrane monoamine transporter; PMAT), with decynium-22 caused a 5-HT1A mediated decrease in glutamate release. Evoked glutamate release was only augmented by decynium-22. In experiments with anaesthetisia, a voltammetric scan optimised for 5-HT was used. Stimulation of cardiopulmonary, chemoreceptor and baroreceptor afferents as well as electrical stimulation of vagal afferents increased the electrochemical signal, which was calcium and frequency dependent. Synthesis inhibitors for 5-HT, but not for noradrenaline, decreased the signal confirming it was 5-HT. Decynium-22 increased the evoked signal but neither citalopram nor desipramine, at doses shown to selectively decrease the removal of 5-HT or noradrenaline, had any effect. Blockade of glutamate receptors with kynurenate reduced the evoked 5-HT by ~50% and this remaining 5-HT was potentiated by decynium-22. Preliminary data from rats with heart failure induced by coronary artery ligation found that glutamate and 5-HT transmission to be augmented within the NTS. These data show that 5-HT release is increased by activation of afferent input and this release is regulated by OCT3/PMAT not 5-HTT. This suggests that 5-HT may act, in part, as a volume transmitter in the NTS. This regulation may be affected by disease such as heart failure.
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James, Angela Shirley. "Mechanisms of action of arginine vasopressin on neurons of the nucleus tractus solitarius." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ42636.pdf.
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Soedling, Helen. "The role of leptin receptors in the endocrine pancreas and nucleus tractus solitarius." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/63933.
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The highly controlled regulation of pancreatic hormone secretion is vital to keep the body’s glucose concentration at a constant level. Defects in the regulation of glucose levels are involved in several metabolic diseases, including type 2 diabetes and obesity. Leptin is a satiety hormone with important roles in the maintenance of body weight and glucose homeostasis. Mice that lack leptin (ob/ob) or the leptin receptor (db/db) are massively obese and have diabetes symptoms. Leptin has been demonstrated to have an effect on glucose homeostasis that is suggested to be secondary to the obesity these animals are suffering from. Currently, it is unclear how leptin regulates glucose homeostasis. Leptin mediates its effects by interaction with its leptin receptor (LepRb), which is highly expressed in the hypothalamus, and at lower levels in the periphery. Leptin’s effect on glucose homeostasis has been proposed to be mediated via its receptor expressed on pancreatic cells affecting insulin secretion. Previous animal studies have deleted the leptin receptor in pancreatic β- and α-cells using either “leaky” or inefficient Cre-drivers resulting in conflicting results on glucose homeostasis. In this study, we use a β-cell selective Ins1Cre promoter in mice to investigate the role of leptin receptor expressed on pancreatic cells effect on glucose homeostasis. Deletion of LepRb was found to have minor effects on glucose tolerance in female animals an effect that was only detected in 8 weeks old animals. No effect was observed in male animals or in females above the age of 8 weeks. It is well established that the LepRb in hypothalamus plays an important role in regulation of energy balance. However, the LepRb is expressed in several areas outside hypothalamus, such as the nucleus of the solitary tract (NTS). GLP-1-expressing neurons in this area express the LepRb and it is therefore possible that these neurons mediate an effect on energy homeostasis or glucose homeostasis. We have therefore deleted LepRb in GLP-1 expressing neurons with a proglucagon specific promoter iGluCre. In this study, we found no effect on body weight or glucose homeostasis in animals deleted for LepRb in GLP-1 expressing neurons. Hypothalamus is the brain region that plays a key role in the regulation of feeding and energy homeostasis. This area contains anorexigenic and orexigenic neurons and intermingled with these neurons are subpopulation of neurons named RIP2Cre neurons expressing insulin. Due to the neurons location in the feeding area of the brain they are most likely having a role in energy homeostasis. Previous studies have suggested that tumour suppressor LKB1 plays a role on body weight and food intake in these neurons. Therefore, we deleted LKB1 selectively in the RIP2Cre neurons but failed to see a difference in body weight.
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Cação, Maria Izaura. "Administração da escola publica estadual : exercicio solitario ou solidario ?" [s.n.], 1989. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250922.
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Orientador: Maria Lucia Rocha Duarte CarvalhoDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação
Made available in DSpace on 2018-07-13T21:27:58Z (GMT). No. of bitstreams: 1 Cacao_MariaIzaura_M.pdf: 9999839 bytes, checksum: 8c2dad06ab249ffc38ece973276ca03b (MD5) Previous issue date: 1989
Resumo: A dissertação, a partir do estudo do sistema educacional paulista, inserido num contexto de burocratização do pais, pós 64, procurou levantar subsídios teóricos e práticos no sentido de discutir as possibilidades ou não da escola pública estadual tornar-se uma agência de transformação social, através de uma gestão democrática. Para tanto, partimos do pressuposto de que a participação, não apenas a nível interno da Unidade Escolar, mas desta aliada a outros movimentos sociais da Sociedade Civil, constitui-se requisito para a democratização, com vistas à construção de uma nova hegemonia - a das camadas subalternas. Como procedimento metodológico, empreendemos uma pesquisa exploratória com Diretores de Escola da Delegacia de Ensino de Moji Mirim, Divisão Regional de Ensino de Campinas, Secretaria de Estado da Educação de são Paulo. Seus resultados corroboram os pressupostos teóricos de que o diretor, assim como a escola pública, não possuem autonomia, nem poder decisório nos aspectos relevantes e substanciais: referentes ao processo educacional e à própria função da escola, enquanto agência de transformação social junto aos interesses dominados, e nem o Diretor possui, ainda, condições de tornar-se o "novo intelectual" a serviço desses interesses
Mestrado
Administração e Supervisão Escolar
Mestre em Educação
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Angeli, Mariella, and Pétrarque. "De Vita solitaria de Pétrarque : édition, traduction et commentaire." Paris 4, 2002. http://www.theses.fr/2002PA040145.
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Le traité de Pétrarque, De uita solitaria, écrit en 1346, mais envoyé seulement vingt ans plus tard à son destinataire Philippe de Cabassoles, évêque de Cavaillon et ami intime de l'auteur, prend la forme d'une longue lettre divisée en deux livres ; dans le premier, l'auteur démontre la supériorité de la vie solitaire en l'opposant à la vie occupée du citadin, qui, victime de ses passions, trompe son ennui dans les villes en s'activant sans cesse et finit par être totalement aliéné. Le second contient une longue liste d'exemples, empruntés à toutes les époques et à toutes les cultures, qui vient confirmer le raisonnement. Pétrarque crée un idéal original qui s'inspire à la fois de la tradition antique de l'otium représentée par Cicéron et Sénèque et de l'idéal ascétique de vie contemplative tel que l'ont vécu les ermites des premiers temps du christianisme ou les moines. Le solitaire vit dans la sérénité, en étroite communion avec la nature et apparaît comme un fin lettré passant sa journée en promenades, lectures d'œuvres profanes et sacrées, travaux de recherche et d'écriture et célébration de Dieu. Cette existence relativement austère est égayée par la visite d'amis dont la présence est ressentie comme une nécessité et un enrichissement. Ils font partie des quelques privilégiés qui peuvent partager cet idéal que Pétrarque a en partie réalisé durant ses séjours à Vaucluse, non loin d'Avignon. Cet ouvrage encore enraciné dans le Moyen Âge finissant, annonce par bien des aspects les transformations de la Renaissance, en mettant l'accent sur la synthèse nécessaire entre cultures antique et chrétienne, sur un rapport nouveau avec la nature et l'importance de l'individualismePetrarch's De uita solitaria treatise, written in 1346, was sent twenty years later, after many alterations, to its addressee, Philippe de Cabassoles, bishop of Cavaillon and one of Petrarch's closest friends ; it is a long letter divided into two books ; in the first one, the author demonstrates the superiority of solitary life, contrasting it to the busy life of the city dweller, who, labouring under his passions, beguiles his tediousness in cities through restlestness, ending in sheer alienation. The second book includes a long list of examples taken from all ages and all cultures meant to illustrate the demonstration. Petrarch creates an original ideal which draws elements from the tradition of ancient otium as Cicero and Seneca pictured it, and from the ascetic and contemplative life such as hermits or monks led it in the early times of Christianity. The solitary man lives serenely, in strict harmony with nature, and is shown as a sharp scholar who spends his days going for walks, reading profane and sacred books, doing research, writing and worshipping God. This way of life, which may appear somewhat austere, is brightened by friends whose visits are regarded as necessary and give rise to rich conversations. They all belong to a privileged few who are invited to share this ideal, partly achieved during Petrarch's stays in Vaucluse, near Avignon. This work, still deeply rooted in the late Middle Ages, foreshadows from many points of wiew the transformations of the Renaissance, for it emphasizes the necessary synthesis between ancient and christian culture, a new relationship with nature and the importance of individualism
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Wang, Sheng. "Effects of nitric oxide on excitatory and inhibitory transmission in the nucleus tractus solitarius." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422549.
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Foley, Charles Michael. "The cardiovascular effects of activation of metabotropic glutamate receptors in the nucleus tractus solitarius /." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9946255.
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Foley, C. Michael. "The cardiovascular effects of activation of metabotropic glutamate receptors in the nucleus tractus solitarius." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9946255.
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Jara, Rebolledo Patricia Andrea, and González Felipe Francisco Olivares. "El aislamiento solitario en las cárceles chilenas una mirada crítica." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/153570.
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Memoria (licenciado en ciencias jurídicas y sociales)La privación de libertad, resultado de un sinfín de factores tanto socioculturales como políticos y jurídicos es un tema que al día de hoy, no ha sido visibilizado de una manera que pueda dar luces de una comprensión real de lo que significa a la luz del Derecho Internacional de los Derechos Humanos, estar dentro de una cárcel. Más aun es necesario dar cuenta, en los tiempos que corren, de las paupérrimas condiciones a las que están sujetos los individuos que ya sea por azar o culpabilidad se encuentran recluidos, pues recordemos que en la cárcel también lamentablemente, hay inocentes. La utopía de la resocialización es un ideal que no se expresa en la realidad carcelaria. Las prisiones terminan siendo el fin y no el medio para la reforma de conducta. En el desarrollo del siguiente trabajo se abordará cómo se desarrolla la vida en las prisiones y de qué forma la autoridad penitenciaria ejerce la disciplina dentro de las mismas, que por regla general, se encuentra al margen de la legislación internacional y nacional vigentes, vulnerando de esta forma los derechos fundamentales de los internos. La presente investigación tratará en específico la aplicación de la medida de aislamiento en celda solitaria, contemplada en el artículo 81 letra j) del Reglamento de Establecimientos Penitenciarios y las diversas repercusiones que acarrea en términos psicológicos, físicos y normativos además de caracterizar las condiciones en que esta se lleva a cabo dentro de las prisiones, con el fin de poner en tela de juicio la aplicación de la misma, como reacción del ente administrativo ante la comisión de faltas que en muchos casos, pareciesen ser de mucha menor entidad que la punición a las mismas.
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Willumsen, Fransson Sara. "Cellular localization of the blood-brain barrier in the brainstem: Area postrema and nucleus tractus solitarius." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9070.
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The blood-brain barrier regulates the transport into the brain and protects the central nerve system (CNS) from toxics substances. However some areas of the brain, called circumventricular organs (CVO), lack the blood-brain barrier. One of these is area postrema (AP), which is located in the brainstem immediately adjacent to the nucleus tractus solitarius (NTS). These two areas together regulate autonomic behaviours such as food intake, and also make up the vomiting center.
The hormones leptin and ghrelin, which regulate food intake, are too big to pass the blood-brain barrier, but have receptors in NTS.
In this study we used immunohistochemistry to obtain a detailed map of the different components of the blood-brain barrier in AP and NTS.
The results suggest that there is a barrier that prevents diffusion of substances from AP into NTS. However, there seems to be some vessels in NTS that have a weaker or no barrier characteristics. These vessels could provide an entrance for peripheral substances to neurons in NTS.
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Donnelly, William T. "Serotonin Signaling in the Nucleus Tractus Solitarius Modulates the Laryngeal Chemoreflex| Implications for Sudden Infant Death Syndrome." Thesis, Dartmouth College, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10145494.
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Sudden infant death syndrome (SIDS) occurs when a sleeping infant experiences a challenge to cardiorespiratory homeostasis which it fails to overcome. Analyses of brain tissue from SIDS cases from around the world consistently show abnormalities in the brainstem serotonin systems. These include increased numbers of neurons that test positive for serotonergic markers, but have an immature phenotype, reduced brain tissue serotonin concentrations and decreased serotonin receptor binding in projection sites important to cardiorespiratory homeostasis, including the nucleus of the solitary tract (NTS). The NTS is of particular interest in the pathophysiology of SIDS because it is the integration center for afferent projections involved in eliciting several apnea-inducing reflexes long suspected of contributing to SIDS. The laryngeal chemoreflex (LCR), an airway protective reflex which is initiated when water, acidic solutions, or low [Cl-] solutions activate chemoreceptors in the larynx, is one such reflex. In infants, inhibitory reflex responses to hypoxia (apnea, bradycardia, decreased metabolic activity) that are adaptive for a fetal environment that precludes the possibility of the fetus acquiring more oxygen by increasing breathing, persist for some time into the postnatal period. Therefore, hypoxia resulting from apnea caused by the LCR can result in a cataclysmic downward spiral of apnea, followed by increasing hypoxic inhibition of respiration, which ultimately leads to SIDS. We hypothesized that increasing serotonin signaling in the brainstems of rat pups would shorten the apnea and respiratory disruption caused by eliciting the LCR. We have shown that both intracisternal injections of serotonin, and microinjections of serotonin into the caudal NTS, dramatically shorten the LCR. This effect is also seen after microinjection into the NTS of the 5-HT3 specific agonist CPG. Chemical stimulation by microinjection of AMPA of neurons in the raphe obscurus, some of which send serotonergic projections to the NTS, also shortens the LCR, but this effect is blocked by prior injection of a 5-HT3 antagonist in the NTS. Our work suggests that serotonergic projections to the NTS from the caudal raphe may play an important role in limiting the duration of apnea following inhibitory reflexes like the LCR and in the subsequent restoration of eupnea.
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Meehan, Amy L. "Impacts of group selection harvest openings on the reproductive success of the Solitary Vireo (Vireo solitarius alticola)." Thesis, Virginia Tech, 1996. http://hdl.handle.net/10919/44965.
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Solitary Vireos (Vireo solitarius alticola) were studied on an extensive mature forest landscape in 1994 and on three sites harvested using the group selection method in 1995. Pairing success was 88% on the unharvested site in 1994, however it was lower on the harvested sites in 1995 (53.8%). Low reproductive success was observed in both years (12% and 22% respectively). In 1995, the amount of opening within a 200 meter radius of the first observation point of a male was positively related to pairing success (p<0.05). This suggests that females may be cueing in on the increased number of shrubs in and around openings.Master of Science
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Blackburn, L. "Behavioural and physiological differences in the motor systems of solitarious and gregarious locusts." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596688.
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There are differences in the walking behaviour of solitarious and gregarious locusts. Gregarious locusts walk 2.5 times faster; steps are longer and higher; the excursion of the femoro-tibial angle of the hind leg is larger; the body is held up and at an angle off the floor and the antennae are held up. Solitarious locusts hold the thorax and abdomen close to and parallel with the ground and hold the antennae down. There are also differences in the firing rate of the slow extensor tibiae motor neuron (SETi) in response to simulated flexion and extension of the leg, achieved by the controlled movement of the apodeme of the femoral chordotonal organ, a proprioceptor that monitors the movement of the leg around the femoro-tibial joint. At all simulated leg angles, the firing rate of SETi is higher in solitarious locusts than in gregarious. Muscle forces of the extensor tibiae (ETi) muscle of the hind leg were measured in response to extracellular stimulation of SETi and the fast extensor tibiae motor neuron (FETi) of the muscle. When SETi is stimulated at 1 Hz, the ETi of gregarious locusts produces twitches that are 3 times the amplitude, and that contract and relax faster than in solitarious. From 7 Hz to 50 Hz there no difference in the amplitude of contradictions produced. Solitarious locusts maintain greater catch tension in the presence of the neuromodulator octopamine, which otherwise potentiates twitch tension and increases the rate of contraction and relaxation of muscle contractions in both phases. When FETi is stimulated at 50 Hz for 10 seconds, there is a decline in tetanus of 32% over the stimulation period in solitarious locusts but 66% in gregarious. Spikes in FETi elicit excitatory post synaptic potentials (EPSPs) in F1Ti motor neurons (Hoyle and Burrows, 1973). The relationship between FETi and FlTi motor neurons was examined using double intracellular recording. At stimulation of 0.5-2 Hz, antidromically induced FETi spikes in solitarious locusts cause a greater degree of depression of flexor EPSPs than in gregarious. At 5-20 Hz there is no difference in EPSP depression, for example 20 Hz depression reaches 20% original amplitude in both phases after a stimulus train of 10 pulses. At all frequencies EPSP amplitude recovers less well in solitarious locusts. When a single stimulus pulse is given 10 seconds after the stimulus train at 20 Hz, EPSP amplitude in gregarious locusts recovers to 76% original height, but only to 63% in solitarious. Firing patterns recorded in FETi and flexors during kicking in solitarious show some similarities and some differences to those previously obtained in gregarious locusts.
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Cárcel, Román Juan Alberto. "Contribución al conocimiento de los tunicados bentónicos solitarios (Chordata: Urochordata) de la Antártida Occidental e Islas del Arco de Scotia." Doctoral thesis, Universidad de Alicante, 2007. http://hdl.handle.net/10045/45726.
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Herman, Melissa Ann. "GABA signaling in the nucleus tractus solitarius (NTS) central control of gastric motility and modulation by endogenous opioids /." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/642326159/viewonline.
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Ponce, Aedo Lorena Andrea. "Expresión de KI-67, P53 y BAX en el epitelio de ameloblastomas sólidos y tumores odontogénicos queratoquísticos solitarios." Tesis, Universidad de Chile, 2013. http://www.repositorio.uchile.cl/handle/2250/117509.
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Trabajo de Investigación Requisito para optar al Título de Cirujano DentistaINTRODUCCIÓN Los Tumores Odontogénicos ( TO ) constituyen un grupo heterogéneo de lesiones, algunas de ellas, con potencial metastásico. Actualmente la clasificación usada para este tipo de lesiones, se basa en la publicada por la OMS el año 2005 que considera su comportamiento biológico, así como, el tipo de tejido odontogénico involucrado. En esta clasificación se realizaron cambios substanciales en relación a la del año 1992, incomporando lesiones, por ejemplo, el Tumor Odontogénico Queratoquístico ( TOQQ ) y aumentando el énfasis clínico-patológico-terapéutico en subdividir al Ameloblastoma en 4 tipos. Para una mayor comprensión del comportamiento clínico de éstas lesiones es necesario entender los mecanismos biológicos y moleculares involucrados en el desarrollo de estas, es por esto que el objetivo de este estudio es describir y comparar la expresión de proteínas, mediante inmunohistoquímica, relacionadas a proliferación celular ( ki-67 ) y apoptosis ( p53 y bax ) MATERIALES Y MÉTODOS Se tomaron 10 muestras de Ameloblastoma Sólido ( AS ) y 10 de TOQQ de entre los años 1998 y 2011, y se sometieron a inmunohistoquímica para ki67, p53 y bax. RESULTADOS Todas las muestras presentaron marcación positiva para los 3 anticuerpos. TOQQ y AS mostraron un índice de marcación de 6,45% y 13,98%, respectivamente. P53 presentó un 6,08% en AS y un 7,0% en TOQQ. Bax mostró un 58% para AS y un 64,65% en el caso de TOQQ. CONCLUSIONES El índice de expresión inmunohistoquímica para el marcador de proliferación celular ki-67, fue más alto para TOQQ que para AS. Pero no se encontraron diferencias estadísticamen significactivas en el caso de p53 y ni bax entre AS y TOQQ.
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Alvarado, Plaza Patricio. "Experiencia de la mercancia arruinada en "Triste, solitario y final" de Osvaldo Soriano." Tesis, Universidad de Chile, 2005. http://www.repositorio.uchile.cl/handle/2250/110266.
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Informe de Seminario para optar al grado de Licenciado en Lengua y Literatura Hispánica mención Literatura.En este informe trabajaré con una novela latinoamericana, particularmente argentina, signada bajo la autoría de Osvaldo Soriano: Triste Solitario y final . Debido a las pretensiones que tengo para con este objeto, atenderé al contexto de producción, pues pretendo interrogar los discursos que lo cruzan y la cultura que lo organiza -siempre datada y sometida a una historicidad-. Sin embargo, este contexto no opera en una sincronía perfecta, por lo tanto, me ocuparé permanentemente de problemáticas que se desarrollan más claramente en la historia de las naciones latinoamericanas con posterioridad al contexto de producción de la novela, utilizando ésta como un nódulo entre una historia anterior y una posterior, es decir, como un espacio de diálogo entre la tradición (¿literaria?) latinoamericana y la lectura que es posible hacer –hoy- bajo el prisma de la novela.
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Ayres, Olavo Martins. "Solitarios - semi nomades (ex-) ameaçados : uma utilização de multimeios na pesquisa : "Os Kayapo atraves da representação" de alguns mamiferos." [s.n.], 1990. http://repositorio.unicamp.br/jspui/handle/REPOSIP/284282.
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Orientadores : Ivan Santo Barbosa , Cory T. de CarvalhoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Artes
Made available in DSpace on 2018-07-13T22:40:36Z (GMT). No. of bitstreams: 1 Ayres_OlavoMartins_M.pdf: 13440931 bytes, checksum: 5a7d66614a0a8f73c542ec6e806606f6 (MD5) Previous issue date: 1990
Resumo: O objetivo do trabalho é investigar com o uso de diapositivos sonorizados, informações relacionadas a um indicador, um referente da natureza (animais mamíferos dos grupos Edentata, Perissodactyla, Dasyproctidae e Cebidae) na cultura material indígena da grande nação Kayapó (Jê). E a partir desta, e de seu registro, busca-se recuperar esta semântica etnobiológica. Analisou-se os métodos de pesquisa utilizados pela etnografia/etnologia, assim como, a documentação visual existente e as informações disponíveis -ou que podem ser friccionadas - nas interfaces: cultura/ambiente, e arte/ciência. Uma contribuição no presente trabalho consiste em uma revisão crítica dessas informações obtidas em trabalhos anteriores, através da ótica da inter-ação metodológica. Vislumbra-se o espaço dos museus a ser explorado; quando propõe aproxima-los das coleções que comporta com a gema de aspectos observáveis e relacionáveis, por intermédio dos meios audiovisuais. Trabalhando num imbricamento da ciência, arte e estética este estudo na área de multimeios propõe atualizar esta interdisciplinaridade
Abstract: The work's goal is to investigate, using sonorized diapositives, informations related to an indicator, a referent from nature (the Edentata, the Perissodactyla, the Dasyoproctidae and the Cebidae), present in the material culture of the great Kayapó Indian nation. As a description of the project we are able to say that this investigation reflects the interest in the Indian codes for visual communication, and in the knowledge that these people have on the animal species wich compose the regional environment where they live. At the same time it reflects the preoccupation with the extinction of these species and of the Indians groups. The methods of research utilized by ethnography / ethnology were analysed as well as the existing visual documentation and the information available within culture / environment and art/science interfaces. One important part of the present work consists in a critical revision of the informations obtained in the previous analysis, in order to meet a methodological interaction. The museum has much to be explored, for this it must bring near the collections it contains, in search of a better profit, obtained from observable relating clues wich are to be supplied the very resources available
Mestrado
Mestre em Multimeios
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Graham, Cathy D. "Chemosensitive Neurons of the Locus Coeruleus and the Nucleus Tractus Solitarius: Three Dimensional Morphology and Association with the Vasculature." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1409665728.
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Santos, Eduardo Alves dos. "“Un solo túnel, oscuro y solitario”: Ernesto Sábato entre o papel e a tela." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2608.
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Este trabalho se situa no âmbito dos estudos inteartes e tem como objeto um estudo comparativo entre as obras O túnel (1948), do escritor argentino Erneto Sábato e o filme homônimo do diretor portenho León Klimovsky (1952). O objetivo desta pesquisa é analisar comparativamente o texto literário e o texto fílmico, a fim de mostrar as estratégias utilizadas pelo diretor para a construção da narrativa fílmica, de modo a trazer ao espectador uma trama existencialista, que no livro se apresenta como uma narração em primeira pessoa e que na estrutura do filme é contada pelos olhos externos de uma câmera e intermediada pela leitura de personagens que não existem na trama de Sábato. Para tanto serão trazidos para a discussão autores que discutem a adaptação de textos literários para o cinema, como Linda Hutcheon, Robert Stam, André Bazin e Sánchez Noriega. Para analisar o conteúdo de temática existencialista, que explicitamente faz parte das influências presentes em ambas as obras recorremos às ideias de Jean Paul Sartre, mais especificamente aos seus textos O existencialismo é um humanismo e Esboço para uma teoria das emoções. Por fim, tendo em conta que Ernesto Sábato foi, além de autor, um reconhecido crítico literário, fazemos uso de alguns de seus textos, como El escritor y sus fantasmas e Heterodoxia, que se voltam para a discussão da sua própria produção estética e para questões que atingem a produção literária de maneira geral.This work is within the scope of interarts studies and has as its object a comparative study between the works The Tunnel (1948), by the Argentine writer Erneto Sábato and the film of the same name by the Buenos Aires director León Klimovsky (1952). This research aims to comparative analysis the literary and the filmic text, in order to show the strategies used by the director for the construction of the film narrative, and by so doing bring to the spectator an existentialist plot, which in the book presents itself as a narration in first person and in the structure of the film is presented through the external eye of a camera and intermediated by the readings carried out by characters that do not exist in the plot of Sábato. For that, authors who discuss the adaptation of literary texts to the cinema, such as Linda Hutcheon, Robert Stam, André Bazin and Sánchez Noriega, will be brought to the discussion. In order to analyze the existentialist theme content, which explicitly forms part of the influences present in both works, we turn to Jean Paul Sartre's ideas, more specifically to his texts Existentialism is a humanism and Sketch for a theory of emotions. Finally, considering that Ernesto Sábato was, besides an author, a recognized literary critic, we make use of some of his texts, such as El escritor y sus fantasmas and Heterodoxia, which turn to the discussion of his own aesthetic production and to Issues that affect literary production in general.
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Jancuska, Sarah Nicole. "Sedimentology and Architecture of a Partially Contained Deposit, Cerro Solitario, Magallanes Basin, Chilean Patagonia." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/83481.
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The depositional styles of sediment gravity currents depend, in part, on the relationship of flow magnitude to the scale of topographically controlled containment and range from unconfined lobes to fully contained deposits. Determining the degree of containment is important for understanding depositional processes, land to ocean sediment transfer and subsurface reservoir characterization/prediction. Depositional models of the fully contained (commonly referred to as 'ponded') end member have been developed (e.g. fill-and-spill model). However, fully contained deposits represent only a portion of deepwater deposits and little work has been done identifying and examining the degree of containment of the more complex, partially contained deposits in outcrop.
Here, I document the sedimentological facies and stratigraphic architecture of the Zorrillo Unit, a partially contained system exposed at Cerro Solitario within the Upper Cretaceous Tres Pasos Formation of the Magallanes Basin. The evolution of partial containment at this outcrop is expressed as: 1) bypass in the proximal zone and flow stripping in the distal zone, 2) backstepping and blanketing of the outcrop, followed by 3) renewed bypass. The partially contained system at Cerro Solitario deviates from the widely used fill-and-spill model due to subtle relief. This record of infilling provides insight into the overall evolution of the depositional system. Within the Magallanes Basin, the partially contained and linked depocenters along the Chingue Clinoform represent the dying breaths of the Cerro Toro axial conglomerate channel system as the canyon-fed point source collapsed and choked off the sediment routing system out to the distal basin.Master of Science
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Infantes, Quijano Gissela, Vera Lourdes Eleana Linares, and Torres Laura Martinez. "Rasgos caracterológicos y hábitos de los conductores de la empresa de transportes el solitario." Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/576169.
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El presente trabajo Descriptivo Comparativo Correlacional titulado “Rasgos Caracterológicos y Hábitos de los Conductores de la Empresa de Transportes El Solitario” está relacionado con el problema del transporte interprovincial de pasajeros, y comprende el análisis de la conducta y hábitos de los conductores de la Empresa de Transporte El Solitario SAC y se plantea como problema de estudio el siguiente cuestionamiento: ¿Existe relación entre los rasgos caracterológicos y los hábitos de los conductores de la ETES?, cuestionamiento que fue confirmado con el desarrollo de esta investigación.
Nuestras conclusiones son: El rasgo caracterológico más significativo de los conductores de la ETES es el Flemático. Asimismo, encontramos que en cuanto a los Factores Hábitos y Actitudes frente al Usuario o Pasajero, Hábitos y Actitudes frente a la Mecánica, Hábitos y Actitudes frente a las Acciones Administrativas, Hábitos y Actitudes frente al Reglamento de Tránsito y Hábitos y Actitudes frente al Trabajo como chofer, todas estas se ubican en el nivel Normal. Entre los rasgos caracterológicos y los hábitos de los conductores encontramos que sí existen diferencias significativas entre los niveles de Actitudes y Hábitos y los Rasgos Caracterológicos. Asimismo existe una correlación Alta entre los Niveles de Hábitos y Actitudes del Chofer frente a la Mecánica, Hábitos y Actitudes del Chofer frente a las Acciones Administrativas, así como en los Hábitos y Actitudes frente al Reglamento de Tránsito; mientras que existe correlación Baja de los Hábitos y Actitudes del Chofer frente al Usuario o Pasajero, de los Hábitos y Actitudes frente al Trabajo como Piloto, así como también existe una correlación estadística Positiva Baja entre los Niveles de Actitudes del Chofer frente a la Salud Laboral y los Tipos Caracterológicos.
Para llegar a dichas conclusiones se trabajó con el personal de la ETES y nuestra muestra fueron 32 conductores, quienes firmaron su consentimiento informado para participar en el estudio. En el desarrollo metodológico del presente estudio se utilizó las siguientes técnicas: Revisión de artículos periodísticos, en diarios, revistas y sistema digital, así como una revisión bibliográfica y la aplicación de dos cuestionarios (listados de preguntas o interrogantes a resolver según criterios de tipo abierto o cerrado): El Cuestionario Caracterológico de Gastón Berger para la primera variable y un Cuestionario de Hábitos y Actitudes del Conductor, para la segunda variable. Para el procesamiento estadístico de datos se empleó el Procesador Estadístico SPSS 20 para Windows.
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Torres, Rodríguez Fatima Kerendy. "Turismo académico en solitario: Beneficios y barreras en estudiantes del Centro Universitario UAEM Texcoco." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2021. http://hdl.handle.net/20.500.11799/110660.
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Tesis de licenciatura en turismoEl estudio de las experiencias de turismo académico es de suma importancia, ya que permite conocer el comportamiento, las vivencias y las expectativas de quienes realizan este tipo de turismo. Por lo tanto, el estudio tuvo por objetivo analizar los beneficios y las barreras de estudiantes del CU UAEM Texcoco al realizar turismo académico dentro de la modalidad de viajes en solitario, reportados desde quienes han participado en estos viajes. De acuerdo con las entrevistas realizadas, la investigación reveló que las y los participantes tuvieron beneficios tanto personales como académicos, sin embargo, los beneficios personales percibidos fueron mayormente reportados en comparación con los académicos. En cuanto al análisis de las barreras, se adoptó la teoría de las restricciones en la recreación y los viajes, por lo tanto, las barreras identificadas fueron agrupadas en barreras intrapersonales, interpersonales y estructurales, siendo estas últimas las que todos los participantes dijeron haber experimentado.
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Silveira, Ludmila Lima. "Envolvimento do processo inflamatório nas alterações observadas na neurotransmissão glutamatérgica no núcleo do trato solitário de ratos submetidos à hipóxia mantida." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-19072018-101050/.
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A hipóxia mantida de curta duração (HM) está associada a alterações cardiorrespiratórias e ao desencadeamento de processo inflamatório em humanos e modelos experimentais. Ademais, há evidências de que a HM pode alterar a transmissão sináptica na região do Núcleo do Trato Solitários (NTS). No presente estudo, utilizamos a minociclina, um inibidor da ativação microglial e antiinflamatório, para avaliar a influência da inflamação desencadeada pela HM sobre a neurotransmissão glutamatérgica nos neurônios do NTS que enviam projeções para a região ventrolateral da medula (NTS-VLM). A hipótese geral do nosso estudo foi a seguinte: a HM induz processo inflamatório no tronco encefálico, o qual contribui para o aumento da neurotransmissão glutamatérgica em neurônios NTS-VLM, colaborando para a elevação da pressão arterial média (PAM) observada nestes ratos. Embora tenhamos observado aumento da pressão arterial média em ambos os grupos de ratos tratados com veículo (solução salina + água destilada, ip) ou minociclina [(30mg/Kg ip por 3 dias) submetidos a 24h de HM (FiO2 0.1) em relação aos seus respectivos grupos controle (FiO2 0,28), o aumento da MAP foi menor nos ratos previamente tratados com minociclina. Os registros eletrofisiológicos utilizando a técnica de whole cell patch-clamp mostraram que a HM não produziu alterações nas propriedades ativas e passivas dos neurônios NTS-VLM. No entanto, os neurônios de ratos submetidos a HM apresentaram aumento nas correntes glutamatérgicas espontâneas e evocadas pelo estímulo do trato solitário. Esse grupo de animais também apresentou aumento no número de microgliais na região do NTS. As alterações mencionadas foram atenuadas pelo tratamento prévio com minociclina. Concluímos que a inflamação induzida pela HM contribui para o aumento da neurotransmissão glutamatérgica nos neurônios NTS-VLM o qual poderia estar relacionado com a hipertensão arterial observada nestes ratos.Short-term Sustained hypoxia (SH) is associated with cardiorespiratory changes and inflammatory process in humans and experimental models. There is also evidence that SH can change the synaptic transmission in the nucleus tractus solitarius (NTS) region. Here we use the minocycline, an anti-inflammatory and microglial inhibitor, to evaluate the role of inflammation triggered by SH on the excitatory neurotransmission in the NTS neurons sending projections to the ventrolateral medulla (NTS-VLM). We hypothesized that SH induces brainstem inflammatory process, which may contribute to increase in excitatory neurotransmission and excitability of the NTS-VLM neurons, collaborating to the high blood pressure observed on these rats. Although we have observed increased MAP in both groups of rats treated with vehicle (saline + distilled water, i.p) or minociclina [(30mg/Kg i.p for 3 days) submitted to 24h of SH (FiO2 0.1) in relation to their respective control groups (FiO2 0.28), the MAP increase was lower in rats treated with minociclina. The whole cell patch-clamp recordings showed that SH produced no changes in active properties of NTS neurons. However, neurons of rats submitted SH presented an increase in the glutamatergic neurotransmission and the number of microglial at the NTS region. These increases were prevented in the groups previously treated with minociclina. We conclude that inflammation induced by SH contributes to the increased excitatory neurotransmission in NTS-VLM neurons that could be associated to high blood pressure observed in these rats.
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St, Lambert Jane Helen Denise. "Action of adenosine at the level of the nucleus tractus solitarii in the hypothalamic defence response." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362875.
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Gummadavalli, Pavan Kumar Nair Satish S. Potts Jeffrey T. "Computational modeling of sensory circuitry in the nucleus tractus solitarii from arterial baroreceptor and somatosensory inputs." Diss., Columbia, Mo. : University of Missouri--Columbia, 2007. http://hdl.handle.net/10355/4941.
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The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on September 10, 2009). Thesis advisor: Dr. Satish S. Nair, Dr. Jeffery T. Potts. Includes "Presentations and Publications" by author. Includes bibliographical references.
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Alves, Fernanda Andrade do Nascimento 1983. "Entre sicários e pistoleiros = uma leitura comparada de O invasor, Rosario tijeras e Un asesino solitario." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/270134.
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Orientador: Miriam Viviana GárateTese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem
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Resumo: O presente trabalho propõe a leitura de três textos literários latino-americanos: O invasor, do brasileiro Marçal Aquino, Rosario Tijeras, do colombiano Jorge Franco, e Un asesino solitario, do mexicano Élmer Mendoza, elegendo como eixo de análise a figuração de um personagem emblemático, o pistoleiro/sicário. Nas três obras, é possível destacar aspectos semelhantes: o delineamento de um outro social, o bandido, ao qual se opõe ou com o qual se relaciona organicamente um representante da classe média/alta; a construção de uma voz narrativa que, em diferentes medidas, coloca em tensão essa relação; a configuração de cidades atravessadas pelo crime e de discursos sobre a violência; a recuperação de um personagem, o bandido, presente na tradição literária anterior de cada país; a adesão a gêneros populares, como o melodrama e o romance policial. Considerando esses aspectos, a tese divide-se em duas partes. Centrando-se no espaço e na voz narrativa, os dois capítulos da primeira parte buscam mostrar como os romances constituem a relação com a alteridade no território urbano e como constroem, ao mesmo tempo, um discurso sobre a cidade e sobre o delinquente. A segunda parte dedica-se ao imaginário cultural em torno do bandido e da figuração da violência. Assim, o terceiro capítulo aborda marcas do romance noir em O invasor, traços melodramáticos em Rosario Tijeras e elementos de tramas policiais em Un asesino solitario. O quarto capítulo propõe um estudo da elaboração da figura do marginal nas literaturas brasileira, colombiana e mexicana, passando, respectivamente, por tipos como o malandro e o cangaceiro, o pájaro e o bandolero. Por fim, o último capítulo dedica-se ao diálogo desses textos literários com os presentes em outros meios, como a televisão, o cinema e a música
Abstract: This study proposes the reading of three Latin American literary texts: O Invasor, written by Brazilian Marçal Aquino, Rosario Tijeras, written by Colombian Jorge Franco and Un asesino solitario, written by Mexican Élmer Mendoza. Elected analysis axis was the emblematic character figuration, the gunman/assassin. In all three texts, it is possible to highlight similar aspects: the design of a social other, the gangster, opposed by or to which organically relates a representative of the middle/upper class; the construction of a narrative voice that, in different measures, puts strain on that relationship; the configuration of cities crossed by the crime and discourses about violence; recovery of a character, the bandit, present in the earlier literary tradition of each country; the adherence to popular genres such as melodrama and detective novel. Considering these aspects, this thesis is divided in two parts. Focusing on space and narrative voice, the two chapters of the first part aim to show how the novels constitute the relationship with otherness in the urban area and how they build up, at the same time, a speech about the city and the delinquent. The second part is devoted to the cultural imaginary around the bandit and the violence figuration. Thus, the third chapter approaches marks of the novel noir in O Invasor, melodramatic traits in Rosario Tijeras and police plots elements in Un asesino solitario. The fourth chapter proposes a study of the development of the marginal figure in Brazilian, Colombian and Mexican literature, through, respectively, types like the trickster and the outlaw, the pájaro and the bandolero. Finally, the last chapter is devoted to dialogue these literary texts with the stories present in other media, such as TV, cinema and music
Doutorado
Teoria e Critica Literaria
Doutora em Teoria e História Literária
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Butcher, James William. "The nucleus tractus solitarii and cardiorespiratory control : the role of neurokinin-1 receptors and potassium channels." Thesis, University of Bristol, 1998. http://hdl.handle.net/1983/588f7506-6822-4a28-9a43-cf75ca1e375e.
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Oliva, Alessandro Marco. "I campi solitonici e l'equazione di Sine-Gordon." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14088/.
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In questo lavoro di tesi verranno presentati inizialmente i concetti di onda solitaria e di solitone e ne verranno descritte le principali proprietà. Questa prima parte dal carattere prettamente matematico verrà poi sfruttata per analizzare a fondo l'equazione di Sine-Gordon, la quale emerge nelle più disparate aree della fisica. In particolare ne ricaveremo alcune soluzioni solitoniche utilizzando il metodo dello scattering inverso, sviluppato appositamente per risolvere equazioni differenziali alle derivate parziali non lineari di questo tipo. Infine, vedremo come l'equazione di Sine-Gordon emerga dallo studio del fenomeno della self-induced transparency.
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Nichols, Nicole L. "The Effects of Chronic Hypoxia and Substance P on the Chemosensitive Response of Individual Nucleus Tractus Solitarius (NTS) Neurons from Adult Rats." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1215465852.
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Fontana, Roberto. "Ciclo riproduttivo annuale del corallo solitario Caryophyllia inornata (Scleractinia, Caryophylliidae) caratterizzato da un inusuale modello di embriogenesi." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/6672/.
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La varietà dei processi riproduttivi dei coralli riflette la loro straordinaria abilità rigenerativa. Le scleractinie sono un noto esempio di animali clonali, che possono esibire una strategia mista di riproduzione sessuale e asessuale per mantenere la loro popolazione. Questo studio descrive per la prima volta il ciclo riproduttivo annuale e l’embriogenesi del corallo temperato Caryophyllia inornata. I campioni sono stati raccolti mediante immersioni subacquee dal relitto di un aereo, a largo delle coste dell’Isola d’Elba. Sono state eseguite analisi citometriche per definire lo sviluppo annuale delle cellule germinali e l’embriogenesi. Caryophyllia inornata è risultata gonocorica con una sex ratio di 1:3.3 a favore dei maschi. I polipi erano sessualmente maturi a 7 mm di lunghezza. Lo sviluppo degli embrioni è stato osservato in maschi, femmine ed individui sessualmente inattivi. Gli spermiari richiedevano circa 10 mesi di maturazione, mentre l’ovogenesi sembrava essere più rapida. I polipi femmina sono stati trovati solo da Febbraio a Luglio. Il tasso di sviluppo gonadico aumentava sensibilmente da Marzo a Maggio e la fecondazione avveniva tra Maggio e Luglio, quando le cellule germinali all’interno dei polipi iniziavano a scomparire. La gametogenesi ha mostrato una forte influenza stagionale mentre gli embrioni sono stati trovati durante tutto l’anno nei maschi e negli individui sessualmente inattivi, non presentando un andamento ben definito. Questo modello di embriogenesi è poco comune ed è stato osservato solo in quattro scleractinie tropicali (Pocillopora damicornis, Tubastrea Diaphana, T. coccinea e Oulastrea crispata) in cui avviene una produzione interna di embrioni per via agamica. La natura precisa di questo processo è ancora sconosciuta.
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Downing, Trevor. "THE RELATIONSHIP BETWEEN LACTIC ACID, REACTIVE OXYGEN SPECIES AND THE HYPOXIA-INDUCED ACIDIFICATION SEEN IN CHEMOSENSITIVE NEURONS OF THE NUCLEUS TRACTUS SOLITARIUS (NTS)." Wright State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=wright1158455199.
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Barros, Lucas Caetano de. "Diferenciação vicariante recente de Oligosarcus argenteus Günther, 1864 e Oligosarcus solitarius Menezes, 1987 nas bacias dos rios Doce e São Francisco, Minas Gerais, Brasil." Universidade Federal de Viçosa, 2012. http://locus.ufv.br/handle/123456789/2260.
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Previous issue date: 2012-04-27The Rio Doce Basin is a coastal drainage isolated from the São Francisco Basin by the Serra do Espinhaço Mountains. Of this basin s 77 known native species, 37 are considered endangered with one of them, Oligosarcus solitarius Menezes 1978, being the only species endemic to the Quaternary lakes. Its sister species, Oligosarcus argenteus Günther, 1864, occurs in the same basin but is restricted to the main channel and tributaries headwaters. The present work aims to determine the specific status of Oligosarcus in the Doce River Basin and included 21 populations from the Doce River Basin and one from the upper Das Velhas River in the São Francisco Basin. This study used morphological, cytogenetic and molecular techniques. Principal Component Analysis (PCA) indicated three groups of populations: one restricted to the headwaters of the Das Velhas River, a second that occurs in the main channel of the headwaters of the Doce River, and a third occurring in the Quaternary lakes. Cytogenetic data (conventional stain, Ag-NOR and C-banding, fluorochromes, FISH, and microsatellite markings) partially corroborated the hypothesis of two groups geographically corresponding to the locals of occurrence of O. solitarius and O. argenteus in the Rio Doce Basin, but also indicated high levels of chromosomal differentiation within each group. The chromosomal variation was similar to that observed in other species of this genus. Molecular data confirmed that the speciation of the two species was recent. Considered together, the data confirmed the occurrence of differentiated but closely related populations in the Quaternary lake system and the existence of two more species in the headwaters of the Das Velhas and Doce Rivers, suggesting the need to re-evaluate the material type collected by Günther in 1861. Considering that the highest degree of chromosomal variation in O. solitarius occurred in the last 14,000 - 3,365 years, we concluded that these sister species present the highest rate of chromosomal evolution in Neotropical fish.
A bacia do rio Doce é uma drenagem costeira e está isolada da bacia do São Francisco pela Serra do Espinhaço. Das 77 espécies nativas conhecidas para a bacia, 37 são consideradas ameaçadas de extinção, sendo Oligosarcus solitarius Menezes 1978 a única espécie endêmica neste sistema de lagoas quaternárias. Sua espécie-irmã, O. argenteus Günther, 1864, ocorre na mesma bacia, mas é restrita à calha e às cabeceiras de tributários. O presente trabalho visa a determinação do status específico das populações de Oligosarcus, a partir da análise de 21 populações da bacia do rio Doce e uma população de Oligosarcus da cabeceira do rio Das Velhas, na bacia do rio São Francisco. A abordagem incluiu o uso de técnicas morfológicas, citogenéticas e moleculares. A análise de componente principal (PCA) indicou a existência de três grupos de populações: a restrita à cabeceira do rio Das Velhas, a que ocorre na calha e cabeceiras do rio Doce e as populações das lagoas quaternárias. Os dados citogenéticos (coloração convencional, Ag-NOR, bandamento C, fluorocromos e FISH e marcador de microssatélite) corroboraram parcialmente a hipótese da existência de dois grandes grupos que correspondem geograficamente aos locais de ocorrência de O. solitarius e O. argenteus na bacia do rio Doce, mas indicaram também altos níveis de diferenciação cromossômica dentro de cada grupo. Os padrões de variação cromossômica assemelharam-se aos indicados para outras espécies do mesmo gênero. Os dados moleculares confirmaram que a especiação das duas espécies foi recente. Considerados em conjunto, os dados confirmam a ocorrência de populações diferenciadas e estreitamente aparentadas no sistema de lagoas quaternárias e a existência de mais duas espécies na cabeceira do rio Das Velhas e do rio Doce e sugerem a necessidade de reavaliação do material tipo coletado por Günther em 1861. Considerando que o alto grau de variação cromossômica de O. solitarius ocorreu nos últimos 14.000 - 3.365 anos, conclui-se que estas espécies-irmãs apresentam a mais alta taxa de evolução cromossômica dos peixes neotropicais.
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Singh, Neha. "Nos1-Adaptor Protein Dysfunction in the Nucleus Tractus Solitarii Contributes to the Neurogenic Heart Damage and Qt Interval Prolongation." Diss., North Dakota State University, 2015. https://hdl.handle.net/10365/27303.
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Variants of the Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) locus are strongly related to QT interval prolongation and sudden cardiac death (SCD) in human. Neurogenic cardiac damage due to subarachnoid hemorrhage, stroke, epilepsy and myocardial infarction is known to contribute to sudden death in most cases. Our aim was to study the role of NOS1AP in the neurogenic cardiac damage by silencing NOS1AP expression in the Nucleus Tractus Solitarii (NTS) area of the brainstem using lentiviral vector-mediated NOS1AP shRNA (Lv-NOS1AP-shRNA). Real time PCR data showed NOS1AP mRNA levels were expressed in the NTS 3-fold higher than other organs such as kidney and heart in Sprague Dawley (SD) rats. Microinjection of Lv-NOS1AP-shRNA in the NTS caused significant reduction in NOS1AP expression in SD rats. NOS1AP knockdown in NTS did not alter blood pressure (BP), heart rate (HR) recorded by radiotelemetry. However, ECG analysis revealed heart rate variability (HRV) was significantly reduced (SDNN, 51.2?5.6 vs 5.0?1.3ms, P< 0.001, n=6) and QTc interval was markedly prolonged (72.4?4 vs 105?11 ms, P< 0.05, n=6) in NOS1AP knockdown rats. Myocardial damage was also observed with the downregulation of NOS1AP in the NTS of SD rats due to the presence of contraction band necrosis. To study the cellular mechanisms underlying NOS1AP action, we investigated the effect of NOS1AP knockdown on NMDA-induced neurotoxicity in primary cultured neuronal cells from the brainstem. Treatment of cells with Lv-NOS1AP-shRNA significantly reduced NOS1AP expression, and was associated with increased NO production and NMDA-induced neurotoxicity, suggesting a protective effect of NOS1AP. Co-immunoprecipitation studies revealed that the association between neuronal Nitric Oxide Synthase (nNOS) and NMDA Receptor (NMDAR) was significantly increased in neurons treated with Lv-NOS1AP-shRNA, suggesting that NOS1AP might compete with NMDAR in binding to nNOS. Therefore, knockdown NOS1AP expression results in increased association between NMDAR and nNOS, leading to elevated glutamate-induced NO production and neurotoxicity. In summary, all results indicate that NOS1AP plays an important role in the protection of neurons from glutamate-induced neurotoxicity. NOS1AP dysfunction in the NTS might increase the risk of neurogenic cardiac damage, leading to QT interval prolongation, even sudden cardiac death.ND-EPSCoR Doctoral Dissertation Assistantship
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Ávila, Adame Anallely. "Solo travel: Motivaciones y experiencias de mujeres mexicanas residentes en la Zona Metropolitana del Valle de México." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2020. http://hdl.handle.net/20.500.11799/109560.
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Tesis de licenciatura en turismoEste estudio exploratorio tuvo por objetivo describir las motivaciones, experiencias y limitaciones turísticas de las mujeres mexicanas residentes en la Zona Metropolitana del Valle de México que realizaron uno o varios viajes en solitario. Se apoyó en la teoría de empuje y arrastre y la teoría de las restricciones de la recreación y los viajes. A través de entrevistas en profundidad, el estudio reveló que, entre otras razones, las mujeres viajan principalmente por motivos de socialización y autoconocimiento, permitiéndoles cierto nivel de autoestima. Las mujeres suelen experimentar restricciones antes y durante los viajes y muchas de sus experiencias están condicionadas a las relaciones tradicionales de género.
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Fernández-Lasquetty, Blanc Blanca. "El cuidado y la satisfacción de las necesidades de los niños de adopción internacional: experiencia en solitario de los padres." Doctoral thesis, Universidad de Alicante, 2017. http://hdl.handle.net/10045/69667.
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Partiendo de la premisa de que enfermería es una disciplina profesional, constituida por tanto por un componente disciplinar y un componente profesional, planteamos esta Tesis con el objeto de aportar a ambos componentes, haciendo explícitas las bases teóricas de la práctica que se plantea. Disciplinarmente, en el terreno del conocimiento, hemos tratado de interpretar un fenómeno de nuestra competencia, el cuidado y la satisfacción de las necesidades de los niños de adopción internacional. Profesionalmente nos hemos interesado por todo aquello que hacen las enfermeras para promocionar y mejorar la salud y el bienestar del niño y su familia y su plena y saludable integración en la sociedad. Puesto que la disciplina es quien gobierna y guía la práctica, hemos hecho explícita la parte disciplinar antes de desarrollar la práctica profesional. Para ello esta Tesis se ha llevado a cabo a través de tres subestudios. El primero de ellos, Aproximaciones teóricas a la satisfacción de las necesidades de los niños de adopción internacional desde la perspectiva enfermera, se trata de una teorización respecto al fenómeno de estudio. Con el objetivo de sustentar teóricamente la satisfacción de las necesidades de los niños de adopción internacional desde la perspectiva enfermera y así justificar su integración en este proceso, se toman como referencia teorías y aportaciones derivadas de diferentes disciplina, partiendo del marco de referencia de la disciplina enfermera, formado por el metaparadigma: persona, entorno, salud y cuidado. El segundo subestudio, Transición a la maternidad en la adopción: análisis cualitativo desde la Teoría Fundamentada, se centra en la mujer como principal proveedora del cuidado familiar, desde la mirada enfermera como proveedora del cuidado profesional. Con el objetivo de explorar y comprender la experiencia de las madres de los niños de adopción internacional en su proceso de transición a la maternidad y convertirse en madre, queriendo junto a ellas identificar las fases de su proceso e identificar las demandas y los recursos cuando pasan por la experiencia de la transición a la maternidad adoptiva, se llevó a cabo este subestudio desde la metodología cualitativa, llevando a cabo entrevistas en profundidad a las madres y siguiendo el marco metodológico de la Teoría Fundamentada. El tercer subestudio de esta Tesis, El valor de la atención de enfermería en el cuidado de los niños de adopción internacional se centra en definir la aportación enfermera al proceso de adopción internacional. Partiendo del proceso enfermero como marco organizado para la práctica de la enfermería profesional, se define la aportación enfermera al proceso de adopción internacional, desarrollando la planificación de los cuidados específica para los niños y su familia. En este subestudio, los discursos de las madres que participaron en el segundo subestudio de esta Tesis constituyen la voz de las familias respecto a las necesidades de los niños. Esta Tesis por tanto constituye una nueva perspectiva de la intervención profesional actual en el proceso de adopción internacional.
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Singh, Neha. "Nitric Oxide Synthase 1 Adaptor Protein Dysfunction in the Nucleus Tractus Solitarii Contributes to the Neurogenic Cardiac Damage and QT Interval Prolongation." Diss., North Dakota State University, 2015. http://hdl.handle.net/10365/24790.
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Gómez, Juárez Luis Enrique. "Efecto del del consumo de extracto de stevia sobre la expresión de deltaFosB en el núcleo del tracto solitario y área tegmental ventral de ratas Wistar." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2019. http://hdl.handle.net/20.500.11799/105762.
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Tesis que describe resultados de experimentos sobre el consumo de extracto de stevia y la expresión del factor de transcripción delta FosBLos edulcorantes de stevia (steviosidos) son edulcorantes naturales no calóricos entre 100 a 300 veces más dulces respecto al azúcar y contienen una mezcla compleja de glúcidos diterpenos. En la actualidad su uso ha ido en aumento debido a una tendencia en el consumo de productos naturales sustitutos del azúcar. Los steviosidos activan al receptor del sabor dulce T1R2-T1R3, que es donde se inicia la transducción de señales. Las vías del gusto se transmiten a través de los pares craneales VII, IX y X hasta llegar a la corteza gustativa primaria con relevos primarios a nivel del tallo cerebral y en núcleos del tracto solitario o del séptimo. El sistema de recompensa evolucionó para satisfacer conductas biológicamente esenciales como alimentación, hidratación, reproducción, cuidado parental e interacciones sociales. Cuando se consumen alimentos se activa la vía mesolímbica de recompensa, de hecho, se puede consumir alimento aún después de haber alcanzado los requerimientos energéticos debido a las propiedades hedónicas de la comida. Investigaciones previas, han reportado la actividad del sistema dopaminérgico por el consumo de sacarosa. Sin embargo, a la fecha no se ha reportado la actividad de este sistema provocado por el consumo de edulcorantes no calóricos. En la actualidad, nuestro grupo de trabajo se encuentra interesado en averiguar si el consumo de dichas sustancias puede activar el sistema dopaminérgico, lo cual sería la puerta de entrada para el establecimiento de una posible adicción. De esta forma las primeras regiones a evaluar en el cerebro son el núcleo del tracto solitario y área tegmental ventral. Para evaluar la actividad de estas áreas, se colocaron dos grupos de 5 ratas machos adolescentes (30-40 días postnatal) un grupo control y un grupo experimental, el grupo control tuvo acceso a agua y alimento ad libitum, respecto a los animales del grupo experimental, estos tuvieron acceso a una solución de extracto de stevia al 0.2% en su agua las 24 horas del día con alimento ad libitum. El tratamiento tuvo una duración de 20 días, al final del tratamiento las ratas fueron anestesiadas con pentobarbital sódico vía intraperitoneal y perfundidas vía intracardiaca con solución salina (0.9%) seguida de paraformaldehído al 4% en 5 PB 0.1 M a fin de lograr la perfusión de los tejidos y realizar la extracción del cerebro. Posteriormente se realizaron secciones coronales de 40 μm del núcleo del tracto solitario (bregma -11.76) y del área tegmental ventral (bregma -6.84) para ser procesados con la técnica de inmunohistoquímica para ΔFosB. Se cuantificaron los núcleos positivos a ΔFosB y se compararon por medio de un Mann-Whitney test. Los resultados en núcleo del tracto solitario indican diferencias significativas en el número de células inmunoreactivas del grupo tratado con extracto de stevia con respecto del control con un valor de U=532.5 y P=0.0089<0.05, en área tegmental ventral indican que existen diferencias significativas en el número de neuronas inmunoreactivas del grupo tratado con stevia respecto al grupo control con un valor de U=487.0 y un valor de P=0.0017<0.05. Los hallazgos indican que en el núcleo del tracto solitario existe expresión del factor de transcripción por lo que la vía del gusto se activa tras el consumo del extracto, y en área tegmental ventral nos indica que el consumo de stevia, activa el sistema de recompensa.
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Ramos, Tafur Dennis Walter. "Estudio a nivel de perfil - SNIP "Sistema de agua potable y saneamiento básico del Centro Poblado Solitario, distrito de Vilquechico, provincia de Huancané, departamento de Puno." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/16297.
Full textAbstract:
Publicación a texto completo no autorizada por el autorMuestra la elaboración de un estudio a nivel de perfil de un proyecto de inversión titulado “Sistema de Agua Potable y Saneamiento Básico del Centro Poblado Solitario”, para el suministro de agua potable al Centro Poblado Solitario ubicado en el distrito de Vilque Chico, provincia de Huancané, departamento de Puno. El centro poblado Solitario cuenta con un sistema de agua para consumo humano construido en 1993 por Foncodes. Dicho sistema cuenta con una captación tipo ladera, siendo la fuente un manantial denominado Muyapequeña localizado sobre los 3989.12 msnm, la fuente Muyapequeña que tiene un caudal de 2 Lt/seg, de las cuales actualmente abastece con un caudal de 1 Lt/seg, mediante un sistema conformado por una línea de conducción de 1550 m, un reservorio de concreto armado de 11 m3, línea de aducción y redes de distribución; tiene conexiones directas sin caja de registro, al interior de la vivienda cuentan con pilones adosados a troncos en muy mal estado. Es de resaltar que este sistema no tiene un sistema de tratamiento.
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Sánchez, Barrenechea Jimena. "EMULIES : el encuentro de las solitarias, el espacio de las sororarias : funcionamiento y gestión de la iniciativa “Espacio de Mujeres Líderes de Instituciones de Educación Superior de las Américas (EMULIES)” entre el 2011 y el 2016." Master's thesis, Pontificia Universidad Católica del Perú, 2019. http://hdl.handle.net/20.500.12404/14518.
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Granjeiro, Érica Maria. "Mecanismos nitrérgicos envolvidos na neurotransmissão dos componentes autonômicos e respiratório do quimiorreflexo no NTS caudal de ratos não-anestesiados." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-16072009-155930/.
Full textAbstract:
O núcleo do trato solitário é uma área integrativa do sistema nervoso central (CNS) envolvida no controle autonômico e respiratório. Estudos da literatura sugerem que o óxido nítrico (NO) exerce um importante papel na modulação dos reflexos cardiovasculares e ventilatórios no NTS. Além disso, evidências da literatura indicam uma possível interação entre o NO e o ATP no SNC. Fundamentados nessas evidências, no presente estudo, avaliamos a possível participação do NO na modulação dos parâmetros cardiorespiratórios basais e no processamento das respostas cardiovasculares e respiratórias à ativação do quimiorreflexo no NTS caudal de ratos não-anestesiados. Além disso, o possível papel do NO produzido pela óxido nítrico sintase neuronal (nNOS) nas respostas cardiovasculares e respiratórias à microinjeção unilateral de ATP no NTS caudal também foi avaliado. Para tanto, os animais foram submetidos ao implante de cânulas guia em direção ao NTS caudal e à canulação da artéria e veia femoral. Os parâmetros ventilatórios foram avaliados pelo método de pletismografia de corpo inteiro. A análise dos resultados monstrou que as microinjeções bilaterais do L-NAME, um inibidor nãoseletivo da NOS, no NTS caudal, promoveram um aumento significativo na pressão arterial basal dos animais, sugerindo um papel modulatório do NO sobre os neurônios envolvidos com as vias neurais do barorreflexo. No entanto, as microinjeções bilaterais do N-PLA, um inibidor seletivo da nNOS, no NTS caudal, não promoveram alterações significativas na pressão arterial basal, sugerindo que a produção do NO envolvido no controle autonômico basal no NTS caudal não é dependente da atividade da nNOS. Com relação às respostas do quimiorreflexo, as microinjeções bilaterais do L-NAME ou do N-PLA, no NTS caudal de ratos nãoanestesiados, promoveram um atenuação significativa no aumento da freqüência respiratória (fR) à ativação do quimiorreflexo, sugerindo a participação do NO Resumo xii produzido pela nNOS na modulação do componente respiratório do quimiorreflexo no NTS caudal. No entanto, as respostas pressora e bradicárdicas decorrentes da ativação do quimiorreflexo não foram alteradas pelas microinjeções bilaterais do LNAME ou N-PLA no NTS caudal, sugerindo que o NO não está envolvido na modulação das respostas cardiovasculares decorrentes da ativação deste reflexo. No que diz respeito às respostas decorrentes da microinjeção de ATP no NTS caudal, a análise dos resultados demonstrou que as respostas de aumento na pressão arterial, fR e ventilação minuto produzidas pela microinjeção unilateral de ATP no NTS caudal de ratos não-anestesiados foram significativamente atenuadas após a microinjeção do N-PLA no mesmo sítio, sugerindo a participação do NO produzido pela nNOS na modulação de tais respostas. Neste contexto, os achados do presente trabalho sugerem que no NTS caudal: 1) o NO, provavelmente produzido pela NOS endotelial, exerce um importante papel modulatório nas vias neurais do barorreflexo; 2) a neurotransmissão do aumento da fR decorrente da ativação do quimiorreflexo envolve a formação de NO produzido pela nNOS; 3) a neurotransmissão das respostas cardiovasculares decorrentes da ativação do quimiorreflexo não envolve a formação de NO; 4) a neurotransmissão das respostas cardiovascualres e respiratórias decorrentes da microinjeção unilateral de ATP envolve a formação de NO produzido pela nNOS.The nucleus tractus solitarius (NTS) is an integrative area in the central nervous system (CNS) involved with the ventilatory and autonomic control. Several studies suggest that nitric oxide (NO) in the NTS plays an important role in the modulation of the cardiovascular and ventilatory reflexes. In addition, there is evidence indicating a possible interaction of NO and ATP in the CNS. Considering these findings, in the present study, we evaluated the possible role of NO on the modulation of the basal cardiorespiratory parameters as well as on the processing of the cardiovascular and ventilatory responses elicited by chemoreflex activation in the caudal NTS of awake rats. In addition, the possible role of NO produced by neuronal nitric oxide sintase (nNOS) on the cardiovascular and respiratory responses produced by unilateral microinjection of ATP into the caudal NTS was also evaluated. For this purpose, rats received bilateral guide cannulae in direction of the caudal NTS and femoral artery and vein were cannulated. The ventilatory measurements were obtained by whole-body pletismograph method. Our data showed that bilateral microinjections of L-NAME, a non-selective NOS inhibitor, into the caudal NTS, produced a significant increase in basaline mean arterial pressure, suggesting a modulatory role of NO in the neural pathways of the baroreflex. However, bilateral microinjections of N-PLA, a selective nNOS inhibitor, into the caudal NTS, produced no significant changes in the baseline mean arterial pressure, suggesting that NO produced by nNOS is not involved in the basal autonomic control in the caudal NTS. With respect to chemoreflex responses, bilateral microinjections of L-NAME or NPLA, into the caudal, produced a significant attenuation in the increase in respiratory frequency (fR) produced by chemoreflex activation, suggesting that NO produced by nNOS is involved in the modulation of the respiratory component of the chemoreflex. However, the pressor and bradicardic responses elicited by chemoreflex actiovation Abstract xv were not affected by microinjections of L-NAME or N-PLA, suggesting that NO is not involved in the modulation of the cardiovascular responses. With respect to ATP microinjection responses, the data showed that unilateral microinjection of ATP into the caudal NTS produced increase in arterial pressure, fR and minute ventilation, which were significantly attenuated by N-PLA, suggesting that NO produced by nNOS is involved in the modulation of the cardiovascular and ventilatory responses to ATP microinjection into the caudal NTS. In conclusion, the data of present study indicate that in the caudal NTS: 1) NO, produced probably by endothelial NOS, plays an important modulatory role on the neural pathways of the baroreflex; 2) the neurotransmission of the increase in respiratory frequency to chemoreflex activation involve NO production by nNOS. 3) NO is not involved in modulation of the autonomic components of chemoreflex; 4) the cardiovascular and ventillatory responses produced by ATP micronjection are, at least in part, mediated by NO produced by nNOS.